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BioRxiv 2024-09-04 Papers

标题 作者 PDF链接 代码仓库 Title
染色质阅读器Dido3是调控B细胞分化基因网络的调节因子。 Gutierrez del Burgo, F. PDF N/A The chromatin reader Dido3 is a regulator of the gene network that controls B cell differentiation
黄矢车菊(Centaurea solstitialis)的染色体规模参考基因组和基于RAD的遗传图谱揭示了与入侵性状相关的潜在结构变异和数量性状位点(QTLs)。 Reatini, B. PDF N/A Chromosome-scale reference genome and RAD-based genetic map of yellow starthistle (Centaurea solstitialis) reveal putative structural variation and QTLs associated with invader traits
Shewanella fidelis 3313 噬菌体调控其运动性和生物膜形成:对强壮海鞘肠道定殖动态的影响 Natarajan, O. PDF N/A Prophage regulation of Shewanella fidelis 3313 motility and biofilm formation: implications for gut colonization dynamics in Ciona robusta
蒙古沙鼠家族特定发声用法的无监督发现 Peterson, R. E. PDF N/A Unsupervised discovery of family specific vocal usage in the Mongolian gerbil
动作电位的消失会诱导神经元之间的电耦合 Schloetter, M. PDF N/A Annihilation of action potentials induces electrical coupling between neurons
通过灵长类抓握回路中与姿势相关的活动,对手部假肢进行精确的神经控制 Agudelo-Toro, A. PDF N/A Accurate neural control of a hand prosthesis by posture-related activity in the primate grasping circuit
M3NetFlow:一种用于综合多组学数据分析的新型多尺度多跳图AI模型 Zhang, H. PDF N/A M3NetFlow: A novel multi-scale multi-hop graph AI model for integrative multi-omic data analysis
GluK1海人藻受体中第9外显子剪接插入的功能意义 Dhingra, S. PDF N/A Functional Implications of the Exon 9 Splice Insert in GluK1 Kainate Receptors
PARP14/TARG1调控的RACK1 MARylation循环驱动卵巢癌细胞中的应激颗粒动态变化 Challa, S. PDF N/A A PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Ovarian Cancer Cells
广布性浮游植物巴氏藻(Bathycoccus)的生物学和基因组资源:对遗传多样性和主要结构变异的洞察 Dennu, L. PDF N/A Biological and genomic resources for the cosmopolitan phytoplankton Bathycoccus: Insights into genetic diversity and major structural variations
dact1/2调控非经典Wnt信号传导和钙蛋白酶8在胚胎趋同延伸和颅面形态发生中的遗传需求 Carroll, S. H. PDF N/A Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis
人类中具有疾病表型的新进化基因揭示了由适应性创新和性选择塑造的功能富集模式。 Chen, J. PDF N/A Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.
电子自旋极化与电荷动力学在蛋白质功能中的作用 Vyas, P. PDF N/A The Role of Electron Spin-Polarizability and Charge Dynamics in Protein Function
欧亚小鳟(鲤科:Phoxinus phoxinus)染色体水平、单倍型解析的基因组组装与注释提供了单倍型多样性的证据。 Oriowo, T. O. PDF N/A A chromosome-level, haplotype-resolved genome assembly and annotation for the Eurasian minnow (Leuciscidae: Phoxinus phoxinus) provide evidence of haplotype diversity
双酚A的质子转移对于激活核外启动的雌激素受体信号传导是必需的。 Medina-Gali, R. M. PDF N/A PROTON TRANSFER FROM BISPHENOL-A IS REQUIRED TO ACTIVATE EXTRANUCLEAR-INITIATED ESTROGEN RECEPTOR SIGNALING
可解释的多模态机器学习(IMML)框架揭示了远端感觉运动性多发性神经病变的病理特征。 Nguyen, P. B. PDF N/A The Interpretable Multimodal Machine Learning (IMML) framework reveals pathological signatures of distal sensorimotor polyneuropathy
药物适应性癌细胞系中的抗药性模式反映了临床肿瘤中复杂的进化过程。 Grimsley, H. E. PDF N/A Resistance patterns in drug-adapted cancer cell lines reflect complex evolution in clinical tumors
干扰抑制仅在视网膜坐标中起作用。 Ilksoy, Y. A. PDF N/A Distractor suppression operates exclusively in retinotopic coordinates
抑制性神经元中神经纤毛蛋白-2表达失调损害海马回路发育,导致自闭症-癫痫表型 Subramanian, D. PDF N/A Dysregulation of Neuropilin-2 Expression in Inhibitory Neurons Impairs Hippocampal Circuit Development Leading to Autism-Epilepsy Phenotype
通过选择性繁殖的小鼠肠道微生物群中的罗伊氏乳杆菌增强了驯服性 Biswa, B. B. PDF N/A Enhanced tameness by Limosilactobacillus reuteri from gut microbiota of selectively bred mice
2P-NucTag:用于功能性识别皮层神经元分子分析的按需光标记技术 Shi, J. PDF N/A 2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons
通过神经网络收敛揭示的视觉人类前额叶激活的文本相关功能 Shoham, A. PDF N/A Text-related functionality of visual human pre-frontal activations revealed through neural network convergence
当前的基因组深度学习架构在草类物种间具有泛化能力,但在等位基因方面不具备泛化能力。 Wrightsman, T. PDF N/A Current genomic deep learning architectures generalize across grass species but not alleles
整合脊椎动物神经管中空间和时间模式化的顺式调控逻辑 Zhang, I. PDF N/A The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
母体肥胖可能通过增加DNMTs(DNA甲基转移酶)导致卵母细胞基因组过度甲基化,从而干扰后代的代谢。 Chao, S. PDF N/A Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs
通过大型语言模型预测TET和DNMT3敲除突变体中的差异甲基化胞嘧啶 sereshki, s. PDF N/A Predicting Differentially Methylated Cytosines in TET and DNMT3 Knockout Mutants via a Large Language Model
抗体依赖性增强在DENV感染的Wistar大鼠中的作用,作为登革热小鼠模型 Wihanto, L. PDF N/A Role of antibody-dependent enhancement in DENV-infected Wistar rats as a dengue murine model
修正关系估计中的模型误设 Jewett, E. M. PDF N/A Correcting model misspecification in relationship estimates
脂肪细胞中的同源域转录因子与产热作用:对人类UCP1的物种特异性及保守调控元件的见解 B. Toth, B. PDF N/A Homeodomain transcription factors in adipocyte thermogenesis: insights into the species-specific and conserved regulatory elements of human UCP1
全基因组条件性降解标签文库在功能基因组学中的应用 Gameiro, E. PDF N/A Genome-wide conditional degron libraries for functional genomics
一种高效预测自然物体感知相似性的高通量方法 Kaniuth, P. PDF N/A A high-throughput approach for the efficient prediction of perceived similarity of natural objects
酒精通过刺激AMPK介导的TORC1、p70/S6K和核糖体生物合成的抑制,诱导神经嵴中p53介导的细胞凋亡。 Huang, Y. PDF N/A Alcohol induces p53-mediated apoptosis in neural crest by stimulating the AMPK-mediated suppression of TORC1, p70/S6K, and ribosomal biogenesis.
在社会变形虫Dictyostelium discoideum中,支配等级是线性的但较为浅显。 Broersma, C. M. E. PDF N/A Dominance hierarchies are linear but shallow in the social amoeba Dictyostelium discoideum.
一个表示静息动作电位尖峰序列的数学序列 Keum, D. PDF N/A A Mathematical Sequence Representing Tonic Action Potential Spike Trains
食肉真菌少孢节丛孢的捕食装置是一种表型系统,用于分离热诱导的过量铁 Zhou, J. PDF N/A Trapping Devices of Carnivorous fungus Arthrobotrys oligospora is a Phenotypic System for Separating Thermally-Induced Excess Irons
纺织结构自动化模型发现:经编面料的独特力学特征 McCulloch, J. A. PDF N/A Automated model discovery for textile structures:The unique mechanical signature of warp knitted fabrics
一氧化碳驱动的生物乙醇生产通过依赖钨的催化剂进行。 Lemaire, O. N. PDF N/A Carbon monoxide-driven bioethanol production operates via a tungsten-dependent catalyst
非周期性和振荡系统构成了人类领域一般认知的基础 Lu, R. PDF N/A Aperiodic and oscillatory systems underpinning human domain-general cognition
用于斑马鱼异种移植模型的自动化微量注射技术 Ding, Y. PDF N/A Automated microinjection for zebrafish xenograft models
非洲慈鲷(Astatotilapia burtoni)的面部和体色与其社会等级有关。 Peros, M. PDF N/A Facial and body colouration are linked to social rank in the African cichlid, Astatotilapia burtoni
葡萄糖激酶活性控制着β细胞的亚群,这些亚群交替主导胰岛Ca²⁺振荡。 Jin, E. PDF N/A Glucokinase activity controls subpopulations of β-cells that alternately lead islet Ca2+ oscillations
穴样蛋白组装体将一个双层叶片的脂质排出,以组织和弯曲膜结构。 Doktorova, M. PDF N/A Caveolin assemblies displace one bilayer leaflet to organize and bend membranes
乳腺癌基因表达的综合元分析 Nwosu, I. O. PDF N/A A Comprehensive Meta-Analysis of Breast Cancer Gene Expression
在乙醇-CPP中追求再巩固:不同条件下的记忆再激活并未引发记忆的不稳定 Zacouteguy Boos, F. PDF N/A Pursuing reconsolidation in ethanol-CPP: memory reactivation in different conditions did not trigger destabilization
远端超级增强子驱动癌细胞中异常的CXCL13表达,通过CXCR5-CXCL13轴促进生长和p53失调 Gothwal, S. K. PDF N/A Distal super-enhancer drives aberrant CXCL13 expression in Cancer cells driving growth and p53 dysregulation via CXCR5-CXCL13 axis
人工自然杀伤细胞模拟系统设计,旨在靶向肿瘤细胞 Chugh, V. PDF N/A Design of an Artificial Natural Killer Cell Mimicking System to Target Tumour Cells
多感官方法在心理意象中的应用:ALE元分析比较运动、视觉和听觉意象 Van Caenegem, E. E. PDF N/A Multisensory approach in Mental Imagery: ALE meta-analyses comparing Motor, Visual and Auditory Imagery
深度对比学习实现了全基因组的虚拟筛选 Jia, Y. PDF N/A Deep contrastive learning enables genome-wide virtual screening
一种利用计算机视觉和DNA条形码技术相结合的无脊椎动物生物监测方法 Blair, J. D. PDF N/A A hybrid approach to invertebrate biomonitoring using computer vision and DNA metabarcoding
钠离子泄漏通道NALCN受到神经元SNARE复合体蛋白的调控。 Usher, S. G. PDF N/A The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins
单细胞多组学揭示了糖原代谢差异,这些差异是物种特异性发育速度的基础 de la Porte, A. PDF N/A Single-cell multiome uncovers differences in glycogen metabolism underlying species-specific speed of development
活体成像与药代动力学:经皮注射的超声与X射线可成像的温度敏感水凝胶负载多柔比星与游离药物在猪体内的比较 Delgado, J. F. PDF N/A In vivo Imaging and Pharmacokinetics of Percutaneously Injected Ultrasound and X-ray Imageable Thermosensitive Hydrogel loaded with Doxorubicin versus Free Drug in Swine
驱动哺乳动物脊髓内运动神经元特异性病毒载荷表达的顺式调控元件 Nagy, M. A. PDF N/A Cis-regulatory elements driving motor neuron-restricted viral payload expression within the mammalian spinal cord
使用CRISPR-CAS9介导的LACZ基因编辑优化以马铃薯皮为葡萄糖源的工程大肠杆菌中脂肪酶的生产与特性分析 Minari, J. B. PDF N/A CRISPR-CAS9 MEDIATED EDITING OF THE LACZ GENE FOR OPTIMIZING LIPASE PRODUCTION AND CHARACTERIZATION IN ENGINEERED ESCHERICHIA COLI USING POTATO PEEL AS A GLUCOSE SOURCE
关于微生物活动在养分循环和转化中的作用及其对土壤肥力和作物生产力的影响的系统综述 Zeleke, T. B. PDF N/A Systematic Review on the Role of Microbial Activities on Nutrient Cycling and Transformation Implication for Soil Fertility and Crop Productivity
IgSeqR:一种从非选择性RNA测序数据中识别、组装和表征全长肿瘤免疫球蛋白转录本的协议 Bryant, D. PDF N/A IgSeqR: a protocol for the identification, assembly, and characterization of full-length tumor Immunoglobulin transcripts from unselected RNA sequencing data
时间基因组动力学塑造多发性骨髓瘤的临床轨迹 MAURA, F. PDF N/A Temporal Genomic Dynamics Shape Clinical Trajectory in Multiple Myeloma
一项多维度的泛癌分析揭示了CDKN1A作为免疫学和预后生物标志物的作用 Shi, L. PDF N/A A multidimensional Pan-cancer analysis of CDKN1A identifies CDKN1A as an Immunological and Prognostic Biomarker
视觉注意对阿拉伯字母识别及阅读习得的影响 Ghandour, A. PDF N/A The influence of visual attention on letter recognition and reading acquisition in Arabic
音乐训练并不增强听觉系统早期阶段的神经声音编码:一项大规模多中心研究 Whiteford, K. L. PDF N/A Musical training does not enhance neural sound encoding at early stages of the auditory system: A large-scale multisite investigation
脑室周围及深部白质高信号阈值在衰老中的变化:指数级进展、认知衰退及神经解剖结构萎缩 Gupta, N. K. PDF N/A Periventricular and Deep White Matter Hyperintensity Thresholds in Aging: Exponential Progression, Cognitive Decline, and Neuroanatomic Atrophy
有药物使用障碍家族史的青年大脑活动动态的性别特异性差异 Schilling, L. S. PDF N/A Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder
整合素激活耶尔森菌蛋白入侵素维持原代上皮细胞的长期扩展,形成二维类器官片层 Wijnakker, J. PDF N/A Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets
小鼠CDK2的不同剪接异构体在有丝分裂和减数分裂过程中发挥功能冗余作用 Palmer, N. PDF N/A Differential splice isoforms of mouse CDK2 play functionally redundant roles during mitotic and meiotic division
哥斯达黎加生态系统服务付费计划的大规模恢复 Delgado, G. L. PDF N/A Large-scale recovery in Costa Rica's Payment for Ecosystem Service Program
引入白三叶草(Trifolium repens L.)后抗旱策略的演变 Hendrickson, B. T. PDF N/A Evolution of drought resistance strategies following the introduction of white clover (Trifolium repens L.)
利用牛津纳米孔长读长测序技术进行生态基因组学实践训练的工作流程 Foster, R. PDF N/A A workflow for practical training in ecological genomics using Oxford Nanopore long-read sequencing
多组学视角下的人类健康:狩猎采集者、农牧民与西方都市人群的肠道微生物群 Singh, H. PDF N/A Multiomic Insights into Human Health: Gut Microbiomes of Hunter-Gatherer, Agropastoral, and Western Urban Populations
物理机制揭示了细菌在鞭毛数量超过临界值时减速的现象 Tatulea-Codrean, M. PDF N/A Physical mechanism reveals bacterial slowdown above a critical number of flagella
抗生素前与抗生素后时代:对耐药性历史传播的洞察 Cazares, A. PDF N/A Pre and Post antibiotic epoch: insights into the historical spread of antimicrobial resistance
热应激使斑马鱼胚胎对神经毒性和心脏毒性更加敏感。 Haapanen-Saaristo, A.-M. PDF N/A Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity.
灵长类尾状核在多模态决策中的独特神经网络及其关键作用 ZENG, Z. PDF N/A Distinct neural manifolds and critical roles of primate caudate nucleus in multimodal decision-making
GC含量对沿物种形成连续体分化区域形成的贡献 Ke, F. PDF N/A Contribution of GC content to differentiated region formation along a speciation continuum
神经元自噬体被转运至星形胶质细胞进行降解。 Linda, K. PDF N/A Neuronal autophagosomes are transported to astrocytes for degradation
权力不对称破坏了社会困境中的互惠合作 Colnaghi, M. PDF N/A Power asymmetry destabilizes reciprocal cooperation in social dilemmas
从影响力指标和开放科学到传播研究:记者对学术争议的认知 Fleerackers, A. PDF N/A From impact metrics and open science to communicating research: Journalists' awareness of academic controversies
波多黎各非裔后裔的基因血统展现了非洲散居人口多样的历史背景。 Nieves-Colon, M. A. PDF N/A Genetic ancestry in Puerto Rican Afro-descendants illustrates diverse histories of African diasporic populations
主要抑郁症的基因年龄差距估计(GAGE):基于基因表达的惩罚性生物年龄模型 Li, Y. PDF N/A Gene Age Gap Estimate (GAGE) for major depressive disorder: a penalized biological age model using gene expression
靶向FOXO4-p53相互作用的肽类抑制剂,诱导衰老癌细胞特异性凋亡 Kang, D. PDF N/A Peptide inhibitors targeting FOXO4-p53 interactions and inducing senescent cancer cell-specific apoptosis
优化针对SARS-CoV-2变种的中和抗体的高通量多重检测方法。 Ashley, C. L. PDF N/A Optimisation of a multiplexed, high throughput assay to measure neutralising antibodies against SARS-CoV-2 variants.
沙门氏菌中的RNase III通过降低宿主免疫反应来增强细菌的致病性。 CHAN, K.-w. B. PDF N/A RNase III in Salmonella Enteritidis enhances bacterial virulence by reducing host immune responses
细菌通过趋同进化对宿主生态位依赖性营养物质的可用性进行代谢重塑 Pickering, A. PDF N/A Bacterial metabolic remodelling by convergent evolution in response to host niche-dependent nutrient availability
丝状蓝藻中的昼夜表达动力学 Kennedy, S. J. PDF N/A Diel expression dynamics in filamentous cyanobacteria
化学遗传相互作用阐明在感染期间控制结核病抗生素效力的途径 Oluoch, P. O. PDF N/A Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection
KatG在msr缺失的鼠伤寒沙门氏菌中抵御H2O2应激的补偿作用 Lalhmangaihzuali, L. PDF N/A Compensatory role of KatG in defending H2O2 stress in msr deletion strain of Salmonella Typhimurium
在埃希氏大肠杆菌菌株中,利用微型核酸酶TnpB、IscB和enIscB进行基因编辑的特征分析 Li, Q. PDF N/A Characterization the gene editing with miniature nucleases TnpB, IscB and enIscB in Escherichia coli strains
反硝化除磷生物反应器中一氧化二氮的生成、机理及建模 Farmer, M. PDF N/A Nitrous oxide production, mechanisms, and modeling from a denitrifying phosphorus removal bioreactor
微生物代谢酶、途径及微生物宿主在废水中共代谢降解有机微污染物中的作用 Lyu, B. PDF N/A Microbial Metabolic Enzymes, Pathways and Microbial Hosts for Co-Metabolic Degradation of Organic Micropollutants in Wastewater
与克罗恩病相关的E. coli采用不同的策略来定殖巨噬细胞。 Bruder, E. PDF N/A E. coli associated with Crohn's disease exhibit distinct strategies to colonize macrophages
TgGloL是一种非典型的含甘油醛/挥发性有机化合物(VOC)结构域的顶质体蛋白,对弓形虫的生长至关重要。 Sanchez, S. G. PDF N/A TgGloL is an atypical glyoxalase/VOC domain-containing apicoplast protein that is important for the growth of Toxoplasma
好氧颗粒形成过程中及进水改造后Accumulibacter及其邻近群落表达的多条胞外聚合物途径 Cardona, L. PDF N/A Multiple extracellular polymeric substances pathways expressed by Accumulibacter and the flanking community during aerobic granule formation and after influent modification
军团菌肺炎铜耐药性:遗传因素和宿主细胞的作用。 Cameron, G. PDF N/A Copper resistance in Legionella pneumophila: role of genetic factors and host cells.
USP37通过TRAIP防止应激复制体过早解体。 Kochenova, O. V. PDF N/A USP37 prevents premature disassembly of stressed replisomes by TRAIP
通过测序进行全基因组RNA-蛋白质相互作用图谱绘制 Qi, Z. PDF N/A Genome-Wide Mapping of RNA-Protein Associations via Sequencing
通过tRNA剪切,将tRNA同工解码器重新用于非经典功能 Bhatter, N. PDF N/A Repurposing tRNA isodecoders for non-canonical functions via tRNA cleavage
神经生长因子trans-Banglene的蛋白质组学研究揭示了其与铁稳态的潜在联系 Gunawardana, P. W. PDF N/A Proteomic Investigation of Neurotrophic trans-Banglene Reveals Potential Link to Iron Homeostasis
选择性多腺苷酸化调节因子CFIm25促进巨噬细胞分化并激活NF-κβ通路 Mukherjee, S. PDF N/A The alternative polyadenylation regulator CFIm25 promotes macrophage differentiation and activates the NF-κβ pathway
SARS-CoV-2 KP.3与ACE2之间增强亲和力的上位效应的结构和分子基础 Feng, L. PDF N/A Structural and molecular basis of the epistasis effect in enhanced affinity between SARS-CoV-2 KP.3 and ACE2
使用CLEANSER对单细胞CRISPR筛选中的环境gRNA进行特征描述和生物信息学过滤 Liu, S. PDF N/A Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER
LevSeq:快速生成序列功能数据,用于定向进化和机器学习 Long, Y. PDF N/A LevSeq: Rapid Generation of Sequence-Function Data for Directed Evolution and Machine Learning
用于生物组织中单个细胞类型的全面分子图谱的关联成像 Yang, M. PDF N/A Correlative Imaging for Comprehensive Molecular Mapping of Individual Cell Types in Biological Tissues
辣椒疫霉效应蛋白AVR3a11的动力学确认了核心WY结构域的折叠 Tolchard, J. PDF N/A Dynamics in the Phytophthora capsici effector AVR3a11 confirm the core WY domain fold
LEA_4基序单独作用并与协同的共溶质结合,以在脱水过程中保护不稳定的酶。 Nicholson, V. PDF N/A LEA_4 motifs function alone and in conjunction with synergistic cosolutes to protect a labile enzyme during desiccation
具有超广底物谱的PL35家族糖胺聚糖裂解酶的晶体结构与催化机制 Wei, L. PDF N/A Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum
通过冷冻电子显微镜观察铁蛋白的有机-无机界面 Sen, S. PDF N/A Observation of the protein-inorganic interface of ferritin by cryo-electron microscopy
甜蜜的科学:利用光学衍射断层成像技术探究果糖和葡萄糖对棕色脂肪细胞分化的影响 Anantha, P. PDF N/A Sweet science: Exploring the impact of fructose and glucose on brown adipocyte differentiation using optical diffraction tomography
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线粒体呼吸链的细胞内结构 Waltz, F. PDF N/A In-cell architecture of the mitochondrial respiratory chain
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一个3D子宫内膜芯片揭示了胚胎来源因子CAPG和PDI在胚胎-子宫内膜交流中的作用 Tinning, H. PDF N/A A 3D endometrium-on-a-chip reveals the role of conceptus-derived factors CAPG and PDI in conceptus-endometrial communication
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