| ESCRT蛋白CHMP5通过调控内溶酶体-线粒体介导的细胞衰老来限制骨形成。 |
Zhang, F. |
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The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence |
| 个性化神经影像揭示了儿童兴趣对大脑语言处理的影响 |
Olson, H. A. |
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N/A |
Personalized Neuroimaging Reveals the Impact of Children's Interests on Language Processing in the Brain |
| 免疫细胞利用间歇性的整合素介导的牵引力进行三维迁移 |
Czerwinski, T. |
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N/A |
Immune cells employ intermittent integrin-mediated traction forces for 3D migration |
| 癌症相关成纤维细胞亚型调节肿瘤免疫微环境，并与皮肤癌恶性程度相关。 |
Forsthuber, A. |
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Cancer associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy |
| 三维变量分析揭示了人类天冬酰胺合成酶中控制氨传输的隐藏构象动力学 |
Coricello, A. |
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3D Variable Analysis Reveal a Hidden Conformational Dynamics Controlling Ammonia Transport in Human Asparagine Synthetase |
| 人类工作记忆和长时记忆中的注意力集中：通过可分离过程带来的益处 |
Gong, D. |
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N/A |
Focusing attention in human working memory and long-term memory: benefits through dissociable processes |
| 健康成人中人诺如病毒的宿内和宿间进化 |
Ramani, S. |
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N/A |
Intra- and Inter-host Evolution of Human Norovirus in Healthy Adults |
| 昆虫变化：评论 |
Gaume, L. |
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N/A |
InsectChange: Comment |
| 自噬限制了真菌在拟南芥根部中的定植 |
Zecua-Ramirez, P. |
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N/A |
Autophagy restricts fungal accommodation in the roots of Arabidopsis thaliana |
| 通过亲和捕获的淋巴细胞冷冻电子断层扫描揭示的胞外纤维 |
Engel, L. |
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N/A |
Extracellular filaments revealed by affinity capture cryo-electron tomography of lymphocytes |
| 利用全细胞模型和机器学习加速设计尺寸减小的埃希氏大肠杆菌基因组 |
Gherman, I. M. |
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N/A |
Accelerated design of Escherichia coli genomes with reduced size using a whole-cell model and machine learning |
| 利用适应度景观建模和强化学习加速蛋白质工程 |
Sun, H. |
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N/A |
Accelerating protein engineering with fitness landscape modeling and reinforcement learning |
| 一种“自杀性”BCG菌株在猕猴中提供了增强的免疫原性和对结核分枝杆菌的强大保护。 |
Smith, A. A. |
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N/A |
A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques |
| 生物传感器表征：从蛋白质组分角度出发的正式方法 |
Arias Vaccari, N. |
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N/A |
Biosensors Characterization: Formal methods from the Perspective of Proteome Fractions |
| 免疫相关蛋白Serpina3n对大脑发育和髓鞘形成的可调控作用 |
Zhu, M. |
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N/A |
Dispensable regulation of brain development and myelination by the immune-related protein Serpina3n |
| 与惊讶的沟通——新奇人类互动中目标信号的计算原理 |
Buidze, T. |
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N/A |
Communication with Surprise-Computational Principles of Goal Signaling in Novel Human Interactions |
| 一线抗结核药物应激下耻垢分枝杆菌的遗传稳定性：评估其诱变潜能 |
Molnar, D. |
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N/A |
Genetic Stability of Mycobacterium smegmatis under the Stress of First-Line Antitubercular Agents: Assessing Mutagenic Potential |
| 小鼠犁鼻器在单细胞分辨率下的分子、细胞和发育组织 |
Hills, M. H. |
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N/A |
Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal Organ at Single Cell Resolution |
| 单细胞MALDI-MSI分析复制性衰老成纤维细胞模型中的脂质和蛋白质 |
Sekera, E. R. |
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N/A |
Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model |
| 早期生活压力诱导的miR-708-5p调控小鼠情绪障碍相关的行为表型，并可能是双相情感障碍的潜在诊断生物标志物。 |
Gilardi, C. |
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Early life stress-induced miR-708-5p regulates mood disorder-associated behavioural phenotypes in mice and is a potential diagnostic biomarker for bipolar disorder |
| 使用AlphaFold预测PROTAC介导的蛋白质-蛋白质界面的挑战 |
Pereira, G. P. |
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N/A |
Challenges in predicting PROTAC-mediated Protein-Protein Interfaces with AlphaFold |
| 成年小鼠中天然前体的动态追踪 |
Liu, S. |
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N/A |
Dynamic Tracking of Native Precursors in Adult Mice |
| 细胞周期依赖性的P-bodies中mRNA定位 |
SAFIEDDINE, A. |
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Cell cycle-dependent mRNA localization in P-bodies |
| PIKFYVE抑制通过氨积累导致源自内体和溶酶体的空泡扩大 |
Uwada, J. |
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PIKFYVE inhibition induces endosome- and lysosome-derived vacuole enlargement via ammonium accumulation |
| 生态而非社会因素解释了头足类动物的大脑尺寸：我们需要一个新的模型来解释大脑进化的过程 |
Basava, K. |
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Ecological not social factors explain brain size in cephalopods: we need a new model for the evolution of big brains |
| 在化学定义的合成饮食中，纯化的纤维会破坏杂食性昆虫模型的肠道微生物群。 |
Dockman, R. |
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N/A |
Purified fibers in chemically defined synthetic diets destabilize the gut microbiome of an omnivorous insect model |
| 脂多糖出口的动态基础由LptB2FGC提供 |
Dajka, M. |
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N/A |
Dynamic basis of lipopolysaccharide export by LptB2FGC |
| 对Physcomitrella N端组学的快照揭示了细胞器蛋白质的N端甲基化 |
Hoernstein, S. N. W. |
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N/A |
A snapshot of the Physcomitrella N-terminome reveals N-terminal methylation of organellar proteins |
| 工程化酿酒酵母以生产富含石榴酸的酵母生物质 |
Wang, J. |
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N/A |
Engineering Saccharomyces cerevisiae for the production of punicic acid-rich yeast biomass |
| 通过泛线粒体基因组图谱揭示的真菌植物病原体中的频繁基因交换 |
van Westerhoven, A. |
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N/A |
Frequent genetic exchanges revealed by a pan-mitogenome graph of a fungal plant pathogen |
| 1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）处理的成年斑马鱼作为帕金森病模型 |
Bagwell, E. |
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N/A |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Treated Adult Zebrafish as a Model for Parkinsons Disease |
| 由PIM1激活的HIF-1组装了一个病理性的转录复合物和调控网络，驱动JAK2V617F骨髓增生性肿瘤疾病的发展。 |
Kealy, D. |
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HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease |
| 长读RNA测序揭示了等位基因特异性的N6-甲基腺苷修饰 |
Park, D. |
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N/A |
Long-read RNA sequencing reveals allele-specific N6-methyladenosine modifications |
| 多模态MEG与微结构MRI研究人类海马场景网络 |
Read, M.-L. |
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Multimodal MEG and microstructure-MRI investigations of the human hippocampal scene network |
| P(all-atom)正在为蛋白质设计开辟新的道路 |
Qu, W. |
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P(all-atom) Is Unlocking New Path For Protein Design |
| 优化基于转录组的合成致死预测，以提高早期乳腺癌的精准肿瘤学：BC-SELECT |
Kim, Y. |
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Optimizing transcriptome-based synthetic lethality predictions to improve precision oncology in early-stage breast cancer: BC-SELECT |
| RBN-2397是一种PARP7抑制剂，与紫杉醇联合使用可协同抑制卵巢癌细胞的增殖和迁移。 |
Spirtos, A. N. |
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RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells |
| 晶体学中的自动晶体识别：直接方法与人工智能策略的比较 |
Lages, C. F. |
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Automatic crystal identification for crystallography: a comparison between direct methods and artificial intelligence strategies |
| 慢性间歇性饮酒会导致皮质-纹状体-边缘系统振荡出现性别特异性的紊乱。 |
Hewitt, K. |
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N/A |
Chronic intermittent alcohol yields sex-specific disruptions in cortical-striatal-limbic oscillations |
| GPRC6A作为一种新型鲜味受体，通过鸟氨酸增强了味觉偏好 |
Yamamoto, T. |
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GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine |
| 在垒球运动中，经过针对性的感知认知训练后，击球技能多年持续提升 |
Muraskin, J. |
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Multiyear Improvement In Batting Skills Following Targeted Perceptual Cognitive Training In Softball |
| 质膜转运蛋白渐进性僵硬蛋白同源物（ANKH/Ankh）介导衰老相关的细胞外柠檬酸盐，并受DNA损伤、炎症和衰老的调控。 |
James, E. N. |
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N/A |
Plasma membrane transporter Progressive Ankylosis Protein Homolog (ANKH/Ankh) mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation and ageing |
| 斑马鱼幼体数量感知的神经基础 |
Luu, P. |
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N/A |
Neural Basis of Number Sense in Larval Zebrafish |
| 疟蚊复杂的群聚动力学源于简单且最小化的互动行为规则。 |
Cribellier, A. |
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N/A |
The complex swarming dynamics of malaria mosquitoes emerges from simple minimally-interactive behavioral rules |
| 实验室观察显示，成年大黄蜂幼虫在夜间仍会继续发出叫声。 |
FUJIOKA, H. |
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N/A |
Laboratory observations reveal that mature Vespa mandarinia larvae continue calling at night |
| 在老鼠视觉皮层中，视觉体验依赖的听觉和视觉可塑性 |
Terra, H. |
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N/A |
Visual experience-dependent auditory and visual plasticity in the mouse visual cortex |
| 全脑电路在自闭症斑马鱼模型中改变听觉习惯化的作用。 |
Wilde, M. |
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N/A |
Brain-wide circuitry underlying altered auditory habituation in zebrafish models of autism. |
| 海马神经突起发育变化与调节低θ振荡相关基因的表达共定位 |
Kember, J. |
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N/A |
Developmental changes in hippocampal neurite colocalize with the expression of genes involved in modulating low-theta oscillations |
| 右侧尾状核体积与注意缺陷/多动障碍（ADHD）儿童的执行功能 |
Hai, T. |
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N/A |
Right Caudate Volume and Executive Functions in Children with Attention-Deficit/Hyperactivity Disorder (ADHD) |
| 人类丘脑内侧背侧核和室旁核中保守的细胞类型梯度 |
Schulmann, A. |
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N/A |
A conserved cell-type gradient across the human mediodorsal and paraventricular thalamus |
| 灵长类动物外侧前额叶皮层神经元中的脉冲频率适应是由内在特性和电路动态相互作用的结果。 |
Koch, N. A. |
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N/A |
Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics |
| 一棵根深蒂固的真核生物树揭示了它们的挖掘祖先起源。 |
Williamson, K. |
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N/A |
A robustly rooted tree of eukaryotes reveals their excavate ancestry. |
| 从聚合的染色质可及性数据推断基因型揭示了遗传调控机制 |
Wenz, B. M. |
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N/A |
Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanisms |
| 孕期接触丙戊酸会导致大鼠皮质和海马神经元结构和功能的性别特异性改变。 |
Williams, O. O. F. |
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N/A |
Prenatal exposure to valproic acid induces sex-specific alterations in cortical and hippocampal neuronal structure and function in rats |
| Arc/Arg3.1 结合核多聚腺苷酸结合蛋白 RRM，并调控神经元活动依赖性的核斑点形成 |
Kanhema, T. |
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N/A |
Arc/Arg3.1 binds the nuclear polyadenylate-binding protein RRM and regulates neuronal activity-dependent formation of nuclear speckles |
| 在刺虫精子发生过程中重组、X染色体失活以及着丝粒蛋白的动态变化 |
Toubiana, W. |
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N/A |
Dynamics of recombination, X inactivation and centromere proteins during stick insect spermatogenesis |
| 在秀丽隐杆线虫的受精囊中，肌动蛋白细胞骨架和顶端细胞连接处的张力受到受精囊解剖结构、排卵状态以及肌球蛋白激活的影响。 |
Sadeghian, F. |
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N/A |
Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin |
| 化学伴侣——山梨醇可纠正罗伯茨突变体的粘附和翻译缺陷 |
BOSE, T. |
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N/A |
Chemical chaperone - sorbitol corrects cohesion and translational defects in the Roberts mutant |
| Piezo1的机械感应通过PP2A-Akt轴调节牙周炎中的破骨细胞分化 |
Shindo, S. |
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N/A |
Mechanosensing by Piezo1 regulates osteoclast differentiation via PP2A-Akt axis in periodontitis |
| Meckel-Gruber综合征蛋白TMEM67通过ADAMTS9蛋白酶解切割生成的两种功能形式介导Wnt信号传导和纤毛发生。 |
Ahmed, M. |
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N/A |
Two functional forms of the Meckel-Gruber syndrome protein TMEM67 generated by proteolytic cleavage by ADAMTS9 mediate Wnt signaling and ciliogenesis |
| 缝隙连接蛋白1与Hippo通路在恶性黑色素瘤中的相互作用 |
Sayedyahossein, S. |
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N/A |
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma |
| Zbtb38通过转录调控XIAP表达来抑制细胞凋亡。 |
Matsuda, E. |
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N/A |
Zbtb38 inhibits apoptosis by transcriptionally regulating XIAP expression |
| 银屑病样炎症诱导人角质形成细胞和成纤维细胞的线粒体功能和结构改变 |
Kulkoviene, G. |
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N/A |
Psoriasis-like inflammation induces mitochondrial function and structure changes in human keratinocytes and fibroblasts |
| RCC1 耗竭导致蛋白质运输缺陷和微核破裂 |
Zych, M. G. |
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N/A |
RCC1 depletion drives protein transport defects and rupture in micronuclei |
| 细胞外囊泡的生物活性和潜在的临床应用价值取决于间充质基质细胞的克隆亚型。 |
Ioannou, S. |
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N/A |
Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype |
| 线粒体移植：一种治疗肝缺血/再灌注损伤的新型疗法 |
Mukkala, A. N. |
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N/A |
Mitochondrial transplantation: a novel therapy for liver ischemia/reperfusion injury |
| 巨轴突神经病变中突变的Gigaxonin与TDP-43及其他RNA结合蛋白相互作用 |
Phillips, C. L. |
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N/A |
Gigaxonin, mutated in Giant Axonal Neuropathy, interacts with TDP-43 and other RNA binding proteins |
| 培养条件差异性调控气管支气管基底干细胞的炎症微环境和细胞表型 |
Murthy, S. |
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N/A |
Culture Conditions Differentially Regulate the Inflammatory Niche and Cellular Phenotype of Tracheo-Bronchial Basal Stem Cells |
| RTN4IP1对于线粒体复合物I组装和辅酶Q生物合成的最后阶段至关重要。 |
Olahova, M. |
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N/A |
RTN4IP1 is essential for the final stages of mitochondrial complex I assembly and coenzyme Q biosynthesis |
| MLX的磷酸化作用稳定了ChREBP-MLX异四聚体在串联E-box上的结合，从而调控碳水化合物和脂质代谢。 |
Shimobayashi, M. |
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N/A |
MLX phosphorylation stabilizes the ChREBP-MLX heterotetramer on tandem E-boxes to control carbohydrate and lipid metabolism |
| MLX磷酸化稳定了ChREBP-MLX异源四聚体在串联E-box上的结合，从而调控碳水化合物和脂质代谢。 |
Cadena del Castillo, C. |
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N/A |
MLX phosphorylation stabilizes the ChREBP-MLX heterotetramer on tandem E-boxes to control carbohydrate and lipid metabolism |
| 脂肪酸在膜脂和储存脂质之间的分配调控内质网膜的扩张。 |
Lysyganicz, P. K. |
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N/A |
The partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion. |
| 果蝇运动决策的时空动态 |
Lebovich, L. |
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N/A |
Spatiotemporal dynamics of locomotor decisions in Drosophila melanogaster |
| 卫星胶质细胞调节背根神经节中本体感受神经元的活动 |
Rabah, Y. |
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N/A |
Satellite glial cells modulate proprioceptive neuron activity in dorsal root ganglia |
| 水通道蛋白-4在嗅上皮中的表达和定位调节了气味诱发的反应和嗅觉驱动的行为 |
Lobraico, D. |
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N/A |
The Aquaporin-4 expression and localization in the olfactory epithelium modulate the odorant-evoked responses and olfactory driven behavior |
| Hox基因，腹部A，控制果蝇中枢神经系统发育过程中神经干细胞的及时有丝分裂进入及其生长。 |
ARYA, R. |
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N/A |
The Hox Gene, abdominal A controls timely mitotic entry of neural stem cell and their growth during CNS development in Drosophila |
| 从组织到亚细胞层面：通过成像人类精密切割肺切片（PCLS）以深入了解大流行细菌或病毒感染 |
Eymieux, S. |
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N/A |
From tissue to subcellular level : imaging human precision-cut lung slices (PCLS) to gain insight into pandemic bacterial or viral infections |
| 阿尔茨海默病脑源性tau聚集物的特性定义了人类星形胶质细胞对tau的加工。 |
Reid, M. J. |
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N/A |
Properties of Alzheimers disease brain-derived tau aggregates define tau processing by human astrocytes. |
| 单次检测微尺度触觉特征 |
Reschechtko, S. |
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N/A |
Single-shot detection of microscale tactile features |
| 使用可调水凝胶解耦触觉湿润感知的冷暖与柔软度 |
Becerra, L. L. |
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N/A |
Decoupling Coldness and Softness in Tactile Wetness Perception Using Tunable Hydrogels |
| 牙龈卟啉单胞菌外膜囊泡改变了胚胎小鼠大脑中的神经元结构和Tau蛋白磷酸化 |
Bradley, A. |
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N/A |
Porphyromonas gingivalis outer membrane vesicles alter neuronal architecture and Tau phosphorylation in the embryonic mouse brain |
| 启动线索的感官背景会调节与动作目标相关的神经表征 |
Kreter, N. |
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N/A |
Sensory context of initiation-cue modulates action goal-relevant neural representations |
| 通过使用FluidFM挑选和放置神经球体，构建具有多种细胞类型的定义明确的神经网络 |
Vulic, K. |
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N/A |
Constructing well-defined neural networks of multiple cell types by picking and placing of neuronal spheroids using FluidFM |
| 脑-身互动影响从心智游移到对当前思维意识的状态转变 |
Shinagawa, K. |
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N/A |
Brain-Body Interactions Influence the Transition from Mind Wandering to Awareness of Ongoing Thought |
| 与内在电导相比，电路功能对突触电导的变化更为鲁棒。 |
Fournier, Z. |
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N/A |
Circuit function is more robust to changes in synaptic than intrinsic conductances |
| 双位点经颅交流电刺激对血氧水平依赖信号的即时调制在整个大脑中传播 |
Hiromitsu, K. |
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N/A |
Immediate Modulation of the Blood Oxygenation Level-Dependent Signals by Dual-Site Transcranial Alternating Current Stimulation Propagates Across the Whole Brain |
| 基于他人学习偏好的政策塑造解释了在社会观察下的冒险决策行为 |
Seon, H. |
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N/A |
Policy shaping based on the learned preferences of others accounts for risky decision-making under social observation |
| 全狨猴大脑的串行双光子断层扫描成像用于神经解剖学分析 |
Watakabe, A. |
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N/A |
Serial Two-Photon Tomography Imaging of the whole marmoset brain for neuroanatomical analyses |
| 一种灵活的高精度光声视网膜假体 |
Leong, A. |
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N/A |
A flexible high-precision photoacoustic retinal prosthesis |
| 听觉伪词的光谱-时间特征和语音特征对多种声音象征映射的差异性贡献 |
Lacey, S. |
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N/A |
DIFFERENTIAL CONTRIBUTIONS OF THE SPECTRO-TEMPORAL AND VOCAL CHARACTERISTICS OF AUDITORY PSEUDOWORDS TO MULTIPLE SOUND-SYMBOLIC MAPPINGS |
| 在小鼠中，周围炎症伴随有脑部血流减少。 |
Kazeem, A. |
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Peripheral Inflammation is accompanied by Cerebral Hypoperfusion in Mice |
| 催产素通过道德框架挽救了特定情境下的超利他偏好 |
Zhang, H. |
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N/A |
Oxytocin salvages context-specific hyperaltruistic preference through moral framing |
| 计算机视觉引导下快速精准的啮齿动物颅内显微手术自动化 |
Navabi, Z. S. |
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N/A |
Computer vision guided rapid and precise automated cranial microsurgeries in rodents |
| 在β冠状病毒家族中，刺突S2域N-糖基化的保守作用 |
Yang, Q. |
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N/A |
Conserved role of spike S2 domain N-glycosylation across beta-coronavirus family |
| 英国诺福克地区2020年3月至2022年12月SARS-CoV-2的基因组流行病学 |
Hayles, E. H. |
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N/A |
Genomic Epidemiology of SARS-CoV-2 in Norfolk, UK, March 2020 - December 2022 |
| 结核分枝杆菌必需转运蛋白A的结构与抑制机制 |
Khandelwal, N. K. |
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N/A |
Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporterefflux protein A |
| Nsp1在DNA发夹处阻碍DNA聚合酶α的进程 |
Baranovskiy, A. G. |
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N/A |
Nsp1 stalls DNA Polymerase alpha at DNA hairpins |
| SARS-CoV-2的主要蛋白酶（Mpro）通过激活凝血因子VII和FXII，在体外引发血浆凝固。 |
Pagotto, A. |
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The Main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII |
| 六种铜绿假单胞菌噬菌体的全基因组序列，旨在用于研究和治疗 |
Rimon, A. |
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N/A |
Complete Genome Sequence of Six Pseudomonas aeruginosa Bacteriophages aim for research and treatments |
| 转录终止和抗终止对于整合接合元件Tn916的适应性和功能至关重要。 |
Wirachman, E. S. |
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N/A |
Transcription termination and antitermination are critical for the fitness and function of the integrative and conjugative element Tn916 |
| CLIC/GEEC途径调控HIV-1感染的巨噬细胞中颗粒的内吞作用及病毒包含体（VCC）的形成 |
Candor, K. |
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The CLIC/GEEC pathway regulates particle endocytosis and formation of the virus-containing compartment (VCC) in HIV-1-infected macrophages |
| 绘制棒状细菌细胞表面的超微结构拓扑图 |
Isbilir, B. |
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N/A |
Mapping the ultrastructural topology of the corynebacterial cell surface |
| 谷氨酸棒杆菌PS2 S层的冷冻电镜结构与极性组装 |
Sogues, A. |
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Cryo-EM structure and polar assembly of the PS2 S-layer of Corynebacterium glutamicum |
| Lachancea thermotolerans中亚群特异性基因表达揭示了葡萄酒发酵过程中不同的代谢适应 |
VICENTE, J. |
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Subpopulation-specific gene expression in Lachancea thermotolerans uncovers distinct metabolic adaptations to wine fermentation |
| 应用条形码测序技术提高恶性疟原虫遗传筛选的通量和复杂性 |
Muwhezi, A. |
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Application of barcode sequencing to increase the throughput and complexity of Plasmodium falciparum genetic screening |
| 磷酸铁试剂法：一种用于研究植物根部细菌产生的氧化还原活性代谢物的工具 |
Giacalone, D. |
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N/A |
The phospho-ferrozine assay: A tool to study bacterial redox-active metabolites produced at the plant root |
| 与时间赛跑：描述奇瓦瓦沙漠中极度濒危的微生物绿洲的微生物多样性 |
Rodriguez-Cruz, U. E. |
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N/A |
Running against the clock: describing microbial diversity in an extremely endangered microbial oasis in the Chihuahuan desert |
| 志贺氏菌效应蛋白IpaH1.4促进RNF213的降解，并保护细胞质中的细菌免受干扰素诱导的泛素化作用。 |
Saavedra Sanchez, L. |
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The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation |
| 抗寄生虫药物塞拉菌素在耻垢分枝杆菌中产生抗药性的可能性不大，且取决于细胞壁的完整性。 |
Ezquerra-Aznarez, J. M. |
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Emergence of resistance to the antiparasitic selamectin in Mycobacterium smegmatis is improbable and contingent on cell wall integrity |
| PIP2促进CD43、PSGL-1和CD44整合入新生的HIV-1颗粒中。 |
Cardoso, R. d. S. |
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PIP2 promotes the incorporation of CD43, PSGL-1 and CD44 into nascent HIV-1 particles |
| 评估选定植物提取物对采后白山药腐烂的抗菌潜力 |
Ibuot, A. A. |
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Assessing the Antimicrobial potentials of selected Plant Extracts against Post Harvest White Yam Rot |
| 针对特定激酶底物的干预措施可缓解由克罗恩病相关LRRK2-N2081D变异体引发的结肠炎严重程度增加 |
Heaton, G. R. |
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Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant |
| 线粒体拓扑异构酶I（Top1MT）可预防小鼠代谢功能障碍相关脂肪性肝炎（MASH）的发生。 |
Baechler, S. A. |
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Mitochondrial topoisomerase I (Top1MT) prevents the onset of metabolic dysfunction-associated steatohepatitis (MASH) in mice |
| 一个南美洲库蚊（双翅目：蚊科）的DNA条形码库，并描述了亚属Melanoconion中的两种隐秘物种。 |
Talaga, S. |
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A DNA barcode library for Culex mosquitoes (Diptera: Culicidae) of South America with the description of two cryptic species of subgenus Melanoconion |
| JN.1衍生的LB.1、KP.2.3、KP.3和KP.3.1.1亚型的中和与稳定性 |
Li, P. |
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Neutralization and Stability of JN.1-derived LB.1, KP.2.3, KP.3 and KP.3.1.1 Subvariants |
| 利用长读长技术对澳大利亚高山石龙子（Bassiana duperreyi）进行基因组组装与注释 |
Hanrahan, B. J. |
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A genome assembly and annotation for the Australian alpine skink Bassiana duperreyi using long-read technologies |
| 对MKP5双特异性磷酸酶的别构调控的动态和结构见解 |
Skeens, E. |
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Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase |
| 基于结构的PROTAC设计用于降解可溶性环氧化物水解酶 |
Schoenfeld, J. |
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STRUCTURE-BASED DESIGN OF PROTACS FOR THE DEGRADATION OF SOLUBLE EPOXIDE HYDROLASE |
| 驱动蛋白-8通过将其近端尾部结构域折叠成一个紧凑的螺旋束而形成二聚体。 |
Allingham, J. S. |
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Kinesin-8 motors dimerize by folding their proximal tail domain into a compact helical bundle |
| CRISPR-Cas9靶向链切割通过抑制复制提供了噬菌体抗性。 |
Nguyen, G. T. |
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CRISPR-Cas9 target-strand nicking provides phage resistance by inhibiting replication |
| 基于人工智能的发现与低温电子显微镜结构解析：一种KATP通道药物伴侣蛋白 |
Elsheikh, A. |
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AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone |
| 通过计算识别能够增加哺乳动物细胞中合成回路基因表达的小分子 |
Pisani, M. |
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N/A |
Computational identification of small molecules for increased gene expression by synthetic circuits in mammalian cells |
| CryptKeeper：一种用于减少细菌中意外基因表达的负面设计工具 |
Roots, C. T. |
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N/A |
CryptKeeper: a negative design tool for reducing unintentional gene expression in bacteria |
| 内源性逆转录病毒通过激活MARCO介导的炎症反应来阻止逆转录病毒感染 |
Xuming, H. |
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N/A |
Endogenous retroviruses activate MARCO-mediated inflammatory response to block retroviral infection |
| SARS-CoV-2 Nsp15 对抗 cGAS-STING 介导的抗病毒先天免疫反应 |
Lee, B. |
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SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses |
| 工业和农业化学品对人类肠道细菌的非预期作用 |
Lindell, A. E. |
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N/A |
Off-purpose activity of industrial and agricultural chemicals against human gut bacteria |
| 转录组规模分析揭示了细菌RNA伴侣Hfq疏水核心中对小调控RNA稳定性至关重要的保守残基 |
McQuail, J. |
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Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability |
| 环境抗生素抗性组：植物根系发育早期阶段HAE-1外排泵的选择 |
Simenel, O. |
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N/A |
Environmental antibiotic resistome: selection of HAE-1 efflux pumps in early stages of plant root development |
| ADAR1 调控 ZBP1 介导的 PANoptosis 和心脏移植排斥反应 |
Lu, H. |
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ADAR1 orchestrates the ZBP1-mediated PANoptosis and heart transplant rejection |
| 红珠之咒：由光毒性引起的成纤维细胞特异性珍珠项链线粒体表型 |
Hemel, I. M. |
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N/A |
The curse of the red pearl: a fibroblast specific pearl-necklace mitochondrial phenotype caused by phototoxicity |
| 使用MS Annika 3.0进行蛋白质组范围的不可切割交联鉴定揭示了秀丽隐杆线虫Box C/D复合物的结构 |
Birklbauer, M. J. |
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Proteome-wide non-cleavable crosslink identification with MS Annika 3.0 reveals the structure of the C. elegans Box C/D complex |
| 哺乳动物与斑胸草雀之间突变和重组参数的保守性 |
Prentout, D. |
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N/A |
Conservation of mutation and recombination parameters between mammals and zebra finch |
| 共享的遗传架构将能量代谢、行为和抗饥饿能力沿着力量-耐力轴联系在一起 |
Erkosar, B. |
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N/A |
Shared genetic architecture links energy metabolism, behavior and starvation resistance along a power-endurance axis |
| 蜜蜂卵的成分随季节变化，并在母体急性病毒感染后发生变化 |
Chapman, A. |
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N/A |
Honey bee egg composition changes seasonally and after acute maternal virus infection |
| 控制蜜蜂（Apis mellifera）蜂王生长的社会和营养因素 |
Kama, O. |
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N/A |
The Social and Nutritional Factors Controlling the Growth of Honey Bee (Apis mellifera) Queens |
| 非线性树突整合支持单个神经元中的上下状态 |
Quaresima, A. |
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N/A |
Nonlinear dendritic integration supports Up-Down states in single neurons |
| 利用TMS-EEG研究在反应性和前瞻性运动抑制过程中GABA能抑制与谷氨酸能兴奋之间的复杂相互作用 |
Zhu, T. |
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N/A |
Using TMS-EEG to study the intricate interplay between GABAergic inhibition and glutamatergic excitation during reactive and proactive motor inhibition |
| 海马体神经元活动与行动计划相一致。 |
Zutshi, I. |
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N/A |
Hippocampal neuronal activity is aligned with action plans |
| 统计学习过程中期望的可分离动态效应。 |
McDermott, H. H. |
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N/A |
Dissociable dynamic effects of expectation during statistical learning. |
| 下丘脑-脑干回路控制着将安全置于基本需求之上的优先级。 |
Krauth, N. |
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N/A |
A hypothalamus-brainstem circuit governs the prioritization of safety over essential needs |
| 使用微图案化的玻璃上突触前模型解析突触前肌动蛋白的纳米级结构 |
Tumminia, S. |
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N/A |
Deciphering the nanoscale architecture of presynaptic actin using a micropatterned presynapse-on-glass model |
| 水田鼠的饮食是否与解释种群波动的植物假说一致？ |
Pinot, A. |
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N/A |
Is water vole diet consistent with the plant hypothesis for explaining population fluctuations? |
| 喜马拉雅地区濒危药用植物刺檗（Berberis lycium Royle）沿海拔梯度的植物-传粉者相互作用 |
Anjum, N. |
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N/A |
Plant-Pollinator Interactions along the Altitudinal Gradient in Berberis lycium Royle: An Endangered Medicinal Plant Species of the Himalayan Region |
| 埃及伊蚊入侵动态变化及其对秘鲁亚马逊地区农村社区的媒介传播疾病风险 |
Fikrig, K. M. |
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N/A |
Changing dynamics of Aedes aegypti invasion and vector-borne disease risk for rural communities in the Peruvian Amazon |
| 公共基因组数据库中高度受限基因的独特特征 |
Agrawal, P. |
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N/A |
Unique Signatures of Highly Constrained Genes Across Publicly Available Genomic Databases |