| 一种基于反义寡核苷酸的策略，用于改善22q11.2缺失综合征中的认知功能障碍 |
Thakur, P. |
PDF |
N/A |
An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome |
| 基于基因组距离的微生物群体结构快速揭示方法（GRUMPS）：一种无需参考的基因组数据清洗方法 |
Abram, K. Z. |
PDF |
N/A |
Genomic Distance-based Rapid Uncovering of Microbial Population Structures (GRUMPS): a reference free genomic data cleaning methodology |
| BrainSuite BIDS App：用于MRI分析的容器化工作流程 |
Kim, Y. |
PDF |
N/A |
BrainSuite BIDS App: Containerized Workflows for MRI Analysis |
| 分子动力学模拟揭示了序列背景在植物基于ELF3-PrD的温度感应机制中的作用 |
Lindsay, R. J. |
PDF |
N/A |
Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants |
| 人类装配体揭示了CACNA1G基因变异在丘脑皮质通路中的后果 |
Kim, J.-i. |
PDF |
N/A |
Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway |
| 多感官整合增强了Mauthner细胞的视听反应 |
Otero Coronel, S. |
PDF |
N/A |
Multisensory integration enhances audiovisual responses in the Mauthner cell |
| 追踪单细胞癌症3D基因组的演变：癌症基因发现的图谱 |
Liu, M. |
PDF |
N/A |
Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery |
| 在健康老化过程中，大脑对语义知识的表征呈现出增强的泛化和特化现象。 |
Margolles, P. |
PDF |
N/A |
Enhanced generalization and specialization of brain representations of semantic knowledge in healthy aging |
| 预期性脑活动依赖于预期刺激的感觉模式：单次试验分析的启示 |
Hoxha, I. |
PDF |
N/A |
Anticipatory brain activity depends on the sensory modality of the expected stimulus: insights from single-trial analyses |
| 去势模型在性别差异研究中的适用性：代谢组学和转录组学分析的启示 |
Jiang, J. |
PDF |
N/A |
Applicability of Castration Model in Sex Difference Studies: Insights from Metabolome and Transcriptome Analyses |
| 室管膜下区神经胶质生成调节脑缺血后胶质瘢痕处的细胞外基质 |
Ardaya, M. |
PDF |
N/A |
Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia |
| MATES：一种基于深度学习的模型，用于单细胞中可移动元件的位点特异性定量 |
Wang, R. |
PDF |
N/A |
MATES: A Deep Learning-Based Model for Locus-specific Quantification of Transposable Elements in Single Cell |
| 翻译启动或延伸抑制在病原体感染期间对秀丽隐杆线虫生存产生对比效应 |
Ghosh, A. |
PDF |
N/A |
Translation initiation or elongation inhibition triggers contrasting effects on Caenorhabditis elegans survival during pathogen infection |
| NF1相关外周神经鞘瘤的基因组特征：来自约翰斯·霍普金斯大学NF1生物样本库的队列分析 |
Banerjee, J. |
PDF |
N/A |
Genomic features of NF1-associated peripheral nerve sheath tumors: a cohort analysis from the Johns Hopkins NF1 biospecimen repository |
| 振幅压缩对注意神经语音追踪是有益还是阻碍？ |
Orf, M. |
PDF |
N/A |
Does amplitude compression help or hinder attentional neural speech tracking? |
| CoCoPyE：用于学习和预测基因组质量指数的特征工程 |
Birth, N. |
PDF |
N/A |
CoCoPyE: feature engineering for learning and prediction of genome quality indices |
| 通过靶向染色质编辑揭示的模拟表观遗传记忆 |
Palacios, S. |
PDF |
N/A |
Analog epigenetic memory revealed by targeted chromatin editing |
| 开发一种实验协议，利用机器人技术和功能性磁共振成像研究手腕运动中力量和阻抗的神经控制 |
Schmidt, K. |
PDF |
N/A |
Development of an Experimental Protocol to Study the Neural Control of Force and Impedance in Wrist Movements with Robotics and fMRI |
| 已撤回：研究音乐在年轻成年人中诱发平静的能力。 |
Shepherd, D. |
PDF |
N/A |
WITHDRAWN: Investigating the ability of music to induce calm in young adults. |
| CTFFIND5 提供了对 TEM 样本质量、倾斜度和厚度的更深入的见解。 |
Elferich, J. |
PDF |
N/A |
CTFFIND5 provides improved insight into quality, tilt and thickness of TEM samples |
| 化学诱导的衰老促使人类类小胶质细胞发生功能性变化 |
Armanville, S. |
PDF |
N/A |
Chemically induced senescence prompts functional changes in human microglia-like cells |
| 体积电子显微镜揭示了死后人类前额叶皮层中的三维突触纳米结构 |
Glausier, J. R. |
PDF |
N/A |
Volume electron microscopy reveals 3D synaptic nanoarchitecture in postmortem human prefrontal cortex |
| 调控网络结构对复杂性状遗传力和进化重要性的影响 |
Stone, K. L. |
PDF |
N/A |
The Importance of Regulatory Network Structure for Complex Trait Heritability and Evolution |
| 顺铂对蛋白质磷酸化的重编程 |
Qi, L. |
PDF |
N/A |
Cisplatin reprogramming of protein phosphorylation |
| 通过调节单个纳米颗粒蛋白质冠与小分子进行深度等离子体蛋白质组分析 |
Ashkarran, A. A. |
PDF |
N/A |
Deep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules |
| 长链非编码RNA Snhg3通过PPARγ信号通路加重肝脂肪变性 |
Xie, X. |
PDF |
N/A |
LncRNA Snhg3 Aggravates Hepatic Steatosis via PPARγ Signaling |
| 通过系统评估化学数据的特性，为以数据为中心的虚拟药物筛选人工智能方法奠定基础 |
Chong, A. |
PDF |
N/A |
Establishing the foundations for a data-centric AI approach for virtual drug screening through a systematic assessment of the properties of chemical data |
| 紫胸木蜂（Xylocopa violacea，林奈，1785年）的基因组序列：一种正在扩展分布范围的膜翅目物种。 |
Nash, W. |
PDF |
N/A |
The genome sequence of the Violet Carpenter Bee, Xylocopa violacea (Linnaeus, 1785): a hymenopteran species undergoing range expansion. |
| 目标学习而非反向传播解释了哺乳动物新皮层中的学习过程 |
Aceituno, P. V. |
PDF |
N/A |
Target Learning rather than Backpropagation ExplainsLearning in the Mammalian Neocortex |
| Atp1a2和Kcnj9是C57BL/6亚系中对羟考酮诱导的运动激活和戒断诱导的焦虑样行为敏感性的候选基因。 |
Goldberg, L. R. |
PDF |
N/A |
Atp1a2 and Kcnj9 are candidate genes underlying sensitivity to oxycodone-induced locomotor activation and withdrawal-induced anxiety-like behaviors in C57BL/6 substrains |
| 环境大肠杆菌中的喹诺酮抗性基因qnr、aac(6')-Ib-cr、oqxAB和qepA：通过比较基因组学对其遗传背景的洞察 |
Gomi, R. |
PDF |
N/A |
Quinolone resistance genes qnr, aac(6')-Ib-cr, oqxAB, and qepA in environmental Escherichia coli: insights into their genetic contexts from comparative genomics |
| 专家指导的蛋白质语言模型能够实现准确且极速的适应性预测 |
Marquet, C. |
PDF |
N/A |
Expert-guided protein Language Models enable accurate and blazingly fast fitness prediction |
| 表面脂质影响线虫发育和物种特异性化学信号传导 |
Kotowska, A. M. |
PDF |
N/A |
Surface lipids influence developmental and species-specific chemical signalling in nematodes |
| 细胞成像与化学结构跨域可以相互补充，用于在化学早期去风险中的大鼠急性口服毒性预测。 |
Camilleri, F. |
PDF |
N/A |
Cell Painting and chemical structure read-across can complement each other for rat acute oral toxicity prediction in chemical early de-risking |
| CellSeg3D：用于光片显微镜的自监督3D细胞分割 |
Achard, C. |
PDF |
N/A |
CellSeg3D: self-supervised 3D cell segmentation for light-sheet microscopy |
| 间接遗传效应增加了可供选择的可遗传变异，并且对于行为来说这种效应最大：一项元分析 |
Santostefano, F. |
PDF |
N/A |
Indirect genetic effects increase the heritable variation available to selection and are largest for behaviours: a meta-analysis |
| 乐观和悲观的认知判断偏差调节斑马鱼的压力反应和癌症进展 |
Espigares, F. |
PDF |
N/A |
Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish |
| 放大双耳间电平差异可增强双侧耳蜗植入者从掩蔽中的空间释放 |
Richardson, B. N. |
PDF |
N/A |
Magnified interaural level differences enhance spatial release from masking in bilateral cochlear implant users |
| 表观遗传年龄模型在新一代甲基化阵列中的适用性 |
Garma, L. D. |
PDF |
N/A |
Applicability of epigenetic age models to next-generation methylation arrays |
| 中央觅食者、猎物耗竭光环以及行为性生态位分隔如何促进消费者共存 |
Rueffler, C. |
PDF |
N/A |
Central place foragers, prey depletion halos, and how behavioral niche partitioning promotes consumer coexistence |
| 在不进行额外训练或数据的情况下，提高逆折叠模型在蛋白质稳定性预测中的表现 |
Dutton, O. |
PDF |
N/A |
Improving Inverse Folding models at Protein Stability Prediction without additional Training or Data |
| 一种改进的四环素诱导型裂殖酵母表达系统 |
Lyu, X.-H. |
PDF |
N/A |
An improved tetracycline-inducible expression system for fission yeast |
| 在或外？利用高分辨率原子力显微镜追踪复杂DNA结构 |
Holmes, E. P. |
PDF |
N/A |
Under or Over? Tracing Complex DNA Structures with High-Resolution Atomic Force Microscopy |
| 物种形成完成率对宏观进化多样化的影响有限 |
Veron, P. |
PDF |
N/A |
Speciation completion rates have limited impact on macroevolutionary diversification |
| CLEC18A与硫酸化的糖胺聚糖相互作用，并调控肾透明细胞癌的进展。 |
Jonsson, G. |
PDF |
N/A |
CLEC18A interacts with sulfated GAGs and controls clear cell renal cell carcinoma progression |
| 哈茨木霉T22通过系统信号诱导根瘤菌和类黄酮，以对抗豌豆中的铁缺乏症。 |
Thapa, A. |
PDF |
N/A |
Trichoderma afroharzianum T22 induces rhizobia and flavonoid through systemic signaling to combat Fe deficiency in garden pea |
| 使用lr-kallisto进行长读长测序转录组定量 |
Loving, R. K. |
PDF |
N/A |
Long-read sequencing transcriptome quantification with lr-kallisto |
| 奖励历史引导胡须体感皮层的焦点注意 |
Ramamurthy, D. L. |
PDF |
N/A |
Reward history guides focal attention in whisker somatosensory cortex |
| Lphn1基因敲除抑制结直肠癌机制的研究 |
wang, Y. |
PDF |
N/A |
Research on the Mechanism of Lphn1 Knockout in Inhibiting Colorectal Cancer |
| 对抗学习能够在大规模范围内实现单细胞RNA数据的跨物种无偏差全生物体对齐。 |
Cooper, S. |
PDF |
N/A |
Adversarial learning enables unbiased organism-wide cross-species alignment of single-cell RNA data at scale |
| 尿液多组学揭示了透明细胞肾细胞癌的非侵入性诊断生物标志物 |
Jonsson, G. |
PDF |
N/A |
Urinary multi-omics reveal non-invasive diagnostic biomarkers in clear cell renal cell carcinoma |
| 动态水凝胶交联强度控制着注射过程中的屈服特性和细胞活力 |
Eckman, N. |
PDF |
N/A |
Dynamic Hydrogel Crosslink Strength Controls Yielding Characteristics and Cell Viability During Injection |
| 单胺氧化酶C（MAO C）的进化与功能分析：MAO基因家族的新成员 |
Merello, G. |
PDF |
N/A |
Evolutionary and Functional Analysis of Monoamine Oxidase C (MAO C): A Novel Member of the MAO Gene Family |
| 内生吡咯喹啉醌增强香蕉生长及对镰刀菌萎蔫病的免疫力，促进植物-微生物共生关系 |
Hung, S.-H. W. |
PDF |
N/A |
Endophytic pyrroloquinoline quinone enhances banana growth and immunity against Fusarium wilt for plant-microbe mutualisms |
| 深度逆向建模揭示了神经回路机制中的动态依赖不变性 |
Gao, R. |
PDF |
N/A |
Deep inverse modeling reveals dynamic-dependent invariances in neural circuit mechanisms |
| BCL2L13 影响自噬和神经酰胺代谢，但不影响胶质母细胞瘤中的替莫唑胺耐药性 |
Clark, C. |
PDF |
N/A |
BCL2L13 Influences Autophagy and Ceramide Metabolism without Affecting Temozolomide Resistance in Glioblastoma |
| BCV和（S）-HPMPA的新型衍生物比BCV更有效地抑制正痘病毒和人类腺病毒。 |
Zhang, Y. |
PDF |
N/A |
Novel derivatives of BCV and (S)-HPMPA inhibit orthopoxviruses and human adenoviruses more potently than BCV |
| 添加留尼汪岛节肢动物名录 |
Nibouche, S. |
PDF |
N/A |
Additions to the list of arthropods of Reunion Island |
| 特定纹状体神经元群的异常过度活跃通过高分辨率聚类揭示了不同的运动障碍行为 |
Alcacer, C. |
PDF |
N/A |
Abnormal hyperactivity of specific striatal ensembles encodes distinct dyskinetic behaviors revealed by high-resolution clustering |
| 解码斑马鱼早期胚胎发育过程中细胞特异性转录异质性和可变剪接 |
Lin, X. |
PDF |
N/A |
Deciphering the Cell Specific Transcript Heterogeneity and Alternative Splicing during the Early Embryonic Development of Zebrafish |
| 解读斑马鱼早期胚胎发育过程中细胞特异性转录异质性和可变剪接 |
Lin, X. |
PDF |
N/A |
Deciphering the Cell-Specific Transcript Heterogeneity and Alternative Splicing during the Early Embryonic Development of Zebrafish |
| 肠道干细胞的增殖和分化依赖于锌指转录因子BCL11/Chronophage。 |
Redhai, S. |
PDF |
N/A |
Proliferation and differentiation of intestinal stem cells depends on the zinc finger transcription factor BCL11/Chronophage |
| 杯状子叶2激活MIR319C转录并在拟南芥叶原基中促进细胞增殖 |
Alanga, N. S. |
PDF |
N/A |
CUP-SHAPED COTYLEDON2 activates MIR319C transcription and promotes cell proliferation in Arabidopsis leaf primordia |
| 在单倍体-二倍体植物马钱子（Marchantia polymorpha subsp. ruderalis）中，选择效力在不同生活阶段有所差异。 |
Shen, T. |
PDF |
N/A |
Selection efficacy differs between lifestages in thehaploid-diploid Marchantia polymorpha subsp. ruderalis |
| 模式工业产油微藻Nannochloropsis oceanica中碳浓缩机制的动态表观基因组景观 |
Gong, Y. |
PDF |
N/A |
Dynamic epigenomic landscape of carbon-concentrating mechanisms in the model industrial oleaginous microalga Nannochloropsis oceanica |
| 一种结合基因组和外显子组测序的方法能够以无偏差、高质量且经济高效的方式捕获遗传变异。 |
Boltz, T. A. |
PDF |
N/A |
A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost-effective manner |
| 金黄色叙利亚仓鼠（Mesocricetus auratus）作为一种模型，用于解析与绵羊相关恶性卡他热的相关致病方面。 |
Fabian, R. |
PDF |
N/A |
The golden Syrian hamster (Mesocricetus auratus) as a model to decipher relevant pathogenic aspects of sheep-associated malignant catarrhal fever |
| 甲基磺酰甲烷：一种针对胶质母细胞瘤多形性中涉及的鞘氨醇激酶1的潜在膳食补充剂 |
Ahmad, F. |
PDF |
N/A |
Methylsulfonylmethane: A Potential Dietary Supplement targeting sphingosine kinase 1 involved in Glioblastomamultiforme |
| 巴基斯坦临床肺炎克雷伯菌中携带blaNDM-1、-5、-7碳青霉烯酶基因的质粒基因组特征分析 |
Qamar, M. U. |
PDF |
N/A |
Genomic characterization of plasmids harboring blaNDM-1,-5,-7 carbapenemase alleles in clinical Klebsiella pneumoniae in Pakistan |
| 光化学过程驱动深海中溶解有机物的温度响应 |
Hu, A. |
PDF |
N/A |
Photochemical processes drive thermal responses of dissolved organic matter in the dark ocean |
| 理解产生侧捏运动的大拇指肌肉小群：应用于神经损伤后抓握功能的手术修复 |
Smith, C. D. |
PDF |
N/A |
Toward an understanding of the small groups of thumb muscles that produce lateral pinch movement: application to surgical restoration of grasp following neurologic impairment |
| MaskMol：用于活性悬崖的像素掩码知识引导分子图像预训练框架 |
cheng, Z. |
PDF |
N/A |
MaskMol: Knowledge-guided Molecular Image Pre-Training Framework for Activity Cliffs with Pixel Masking |
| 利用RNA-seq解析羽扇豆（Lupinus angustifolius）种子发育过程中的转录编程 |
WAINAINA, V. |
PDF |
N/A |
Deciphering transcriptional programming during lupin (Lupinus angustifolius) seed development using RNA-seq |
| 根据三维形态测量学见解，田鼠亚科啮齿动物（Rodentia）颅骨的演化：第一部分。腭蝶翼骨复合体的形态差异 |
Voyta, L. L. |
PDF |
N/A |
Evolution of the skull in arvicoline cricetids (Rodentia) according to 3D morphometric insights: Part 1. Morphological disparity of the palato-spheno-pterygoid complex |
| 在发育过程中恢复短暂连接性可改善脆性X小鼠的功能障碍 |
Dumontier, D. |
PDF |
N/A |
Restoring transient connectivity during development improves dysfunctions in fragile X mice |
| 高分辨率fMRI中的模糊波纹伪影：识别、成因及缓解方法 |
Huber, L. |
PDF |
N/A |
Fuzzy ripple artifact in high resolution fMRI: identification, cause, and mitigation |
| 在创意讲故事过程中，创意生成与评估之间存在动态循环 |
Liang, X. |
PDF |
N/A |
Dynamic cycles between idea generation and evaluation during creative storytelling |
| 功能性见解：全球野化对猫肠道微生物群的影响 |
Aizpurua, O. |
PDF |
N/A |
Functional insights into the effect of feralisation on the gut microbiota of cats worldwide |
| 对全球范围内野化对猫肠道微生物群影响的功能性见解 |
Aizpurua, O. |
PDF |
N/A |
Functional insights into the effect of feralisation on the gut microbiota of cats worldwide |
| 南非现存最大规模的蓝角马（Connochaetes taurinus taurinus）迁徙种群的遗传多样性与种群历史 |
Szarmach, S. |
PDF |
N/A |
Genetic diversity and demographic history of the largest remaining migratory population of blue wildebeest (Connochaetes taurinus taurinus) in southern Africa |
| 南非现存最大规模的蓝角马（Connochaetes taurinus taurinus）迁徙种群的遗传多样性与种群历史 |
Szarmach, S. |
PDF |
N/A |
Genetic diversity and demographic history of the largest remaining migratory population of blue wildebeest (Connochaetes taurinus taurinus) in southern Africa |
| 一种稳健的无监督聚类方法用于高维生物成像数据，揭示了共享的药物诱导形态特征 |
Bao, S. C. |
PDF |
N/A |
A robust unsupervised clustering approach for high-dimensional biological imaging data reveals shared drug-induced morphological signatures |
| 水杨酸抑制细胞伸长并诱导液泡形态和pH值的变化。 |
Mueller, J. |
PDF |
N/A |
Salicylic Acid restricts cell elongation and induces changes of vacuolar morphology and pH |
| 细胞骨架破坏对质膜受体动力学的对比效应：来自单分子分析的见解 |
Rohr, L. |
PDF |
N/A |
Contrasting Effects of Cytoskeleton Disruption on Plasma Membrane Receptor Dynamics: Insights from Single-Molecule Analyses |
| 改变拟南芥的糖代谢会影响分泌物、免疫反应以及植物与微生物的相互作用 |
Siffert, A. |
PDF |
N/A |
Altered Arabidopsis thaliana sugar metabolism affects exudation, immune responses, and plant-microbe interactions |
| 细胞几何结构、微管锚定及各向异性的动态不稳定性：横向皮质阵列组织的挑战与解决方案 |
Tian, T. Y. Y. |
PDF |
N/A |
Cell geometry, microtubule anchoring and anisotropic dynamic instability: challenges and solutions to transverse cortical array organization |
| 跨物种相互作用组分析揭示了植物中一种保守的选择性自噬机制，用于蛋白质质量控制 |
Hernandez, V. S. d. M. |
PDF |
N/A |
Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants |
| 停止速度作为状态而非特质：探究多轮停止信号任务中动物间停止速度的差异 |
ter Horst, J. |
PDF |
N/A |
Stopping Speed as State, Not Trait: Exploring Within-Animal Varying Stopping Speeds in a Multi-Session Stop-Signal Task |
| 视觉逃避习惯化中个体差异的神经回路 |
Liu, X. |
PDF |
N/A |
Neural Circuit Underlying Individual differences in Visual Escape Habituation |
| HHIP在表皮伤口愈合中的动态作用揭示了COPD易感性的潜在机制 |
Deritei, D. |
PDF |
N/A |
HHIP's Dynamic Role in Epithelial Wound Healing Reveals a Potential Mechanism of COPD Susceptibility |
| 马拉维分离株中T. b. rhodesiense血清抗性相关基因的遗传多样性 |
Nambala, P. |
PDF |
N/A |
GENETIC DIVERSITY OF T. B. RHODESIENSE SERUM RESISTANCE ASSOCIATED GENE IN MALAWIAN ISOLATES |
| 等位基因特异性表达在肿瘤发生过程中被选择，源于表观遗传变化，并与预后相关。 |
Palou-Marquez, G. |
PDF |
N/A |
Allele-specific expression is selected in tumorigenesis, results from epigenetic changes and has prognostic relevance |
| 15基因预后特征，其中TFAP2B在卵巢癌铂耐药中发挥作用 |
Hu, Y. |
PDF |
N/A |
A 15-Gene prognostic signature with TFAP2B functioning in Platinum Resistance of Ovarian Carcinoma |
| 进化与生命在多个粒度上的分支紧密相连。 |
Douglas, J. |
PDF |
N/A |
Evolution is coupled with branching across many granularities of life |
| 一种基于胍的冠状病毒复制抑制剂，靶向nsp15内切核糖核酸酶，结合了直接的抗病毒效果与微妙的干扰素增强作用。 |
Van Loy, B. |
PDF |
N/A |
A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and combines a direct antiviral effect with subtle boosting of interferon |
| CRISPR-CLEAR：通过平铺碱基编辑的等位基因读出实现调控元件的核苷酸分辨率映射 |
Becerra, B. |
PDF |
N/A |
CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing |
| 与AK2A的相互作用将AIFM1与细胞能量代谢联系起来 |
Rothemann, R. A. |
PDF |
N/A |
Interaction with AK2A links AIFM1 to cellular energy metabolism |
| 选择性氘化RNA:RNA复合物用于结构分析的小角散射 |
Munsayac, A. |
PDF |
N/A |
Selective deuteration of an RNA:RNA complex for structural analysis using small-angle scattering |
| 磷脂酰肌醇聚焦的CRISPR筛选识别出胰腺导管腺癌（PDAC）和急性髓系白血病（AML）细胞中的新型遗传脆弱性 |
Lee, D. K. |
PDF |
N/A |
Phosphoinositide-focused CRISPR screen identifies novel genetic vulnerabilities in PDAC and AML cells |
| 长期热应激增强蚊子对病毒感染的耐受性 |
Perdomo, H. D. |
PDF |
N/A |
Prolonged thermal stress enhances mosquito tolerance to viral infection |
| Kinbiont：从时间序列到微生物系统中的生态和进化响应 |
Angaroni, F. |
PDF |
N/A |
Kinbiont: From time series to ecological and evolutionary responses in microbial systems |
| 铜绿假单胞菌在呼吸道感染期间面临一种适应性权衡，即在黏膜定植与抗生素耐受性之间做出选择。 |
Meirelles, L. A. |
PDF |
N/A |
Pseudomonas aeruginosa faces a fitness trade-off between mucosal colonization and antibiotic tolerance during airway infections |
| 通过拓扑约束分子生成模型发现针对COVID-19的新型喹啉类木瓜蛋白酶样蛋白酶抑制剂 |
Shang, J. |
PDF |
N/A |
Discovery of novel quinoline papain-like protease inhibitors for COVID-19 through topology constrained molecular generative model |
| 通过蛋白质组学检测ESKAPE病原体的抗生素抗性并同时鉴定其物种 |
Blumenscheit, C. |
PDF |
N/A |
Antibiotic resistance detection and concomitant species identification of ESKAPE pathogens by proteomics |
| 利用PREDAC模型模拟季节性流感病毒的抗原进化，以在2025年季节中选择疫苗株 |
Peng, Y. |
PDF |
N/A |
Modeling the antigenic evolution of seasonal influenza viruses with PREDAC for vaccine strain selection in the season of 2025 |
| 利用CRISPR-Cas13d在诱导性敲降系统中研究果蝇生殖颗粒mRNA |
Gauhar, Z. A. |
PDF |
N/A |
Leveraging CRISPR-Cas13d in an inducible knockdown system to interrogate Drosophila germ granule mRNAs |
| SIRT6缺失通过促进衰老和SASP状态导致小鼠椎间盘退变 |
Ramteke, P. |
PDF |
N/A |
SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status |
| 拟南芥tRNA氨基酸化作用的景观 |
Ceriotti, L. F. |
PDF |
N/A |
The landscape of Arabidopsis tRNA aminoacylation |
| 高质量的肽段证据用于注释非规范开放阅读框为人类蛋白质 |
Deutsch, E. W. |
PDF |
N/A |
High-quality peptide evidence for annotating non-canonical open reading frames as human proteins |
| 高吞吐量酶促DNA甲基化测序的经济高效解决方案 |
Longtin, A. |
PDF |
N/A |
Cost-effective solutions for high-throughput enzymatic DNA methylation sequencing |
| 转录因子网络对血液细胞表型的遗传性具有不成比例的富集作用 |
Martin-Rufino, J. D. |
PDF |
N/A |
Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes |
| 将新开发的SNP条形码面板与微卫星进行比较，以探索秘鲁亚马逊地区疟疾病原体的群体遗传学 |
Cabrera-Sosa, L. |
PDF |
N/A |
Comparing newly developed SNP barcode panels with microsatellites to explore population genetics of malaria parasites in the Peruvian Amazon |
| 一种致病突变如何从单体到完全组装状态损害Hsp60的功能动态 |
Torielli, L. |
PDF |
N/A |
How a pathogenic mutation impairs Hsp60 functional dynamics from monomeric to fully assembled states |
| 一种与能量平衡相关的次级β-羟基丁酸代谢途径 |
Moya-Garzon, M. D. |
PDF |
N/A |
A secondary β-hydroxybutyrate metabolic pathway linked to energy balance |
| 通过FeII/2-氧代戊二酸依赖的双加氧酶进行非耦合琥珀酸生产的比较分析 |
Das, S. |
PDF |
N/A |
Comparative analysis of uncoupled succinate production by the FeII/2-oxoglutarate-dependent dioxygenases |
| 尿酸在人类URAT1中的转运机制及促尿酸排泄药物的抑制作用 |
Guo, W. |
PDF |
N/A |
Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1 |
| 人类心脏类器官的成熟对于疾病建模和药物发现是必要的。 |
Pocock, M. |
PDF |
N/A |
Maturation of human cardiac organoids are required for disease modelling and drug discovery |
| 结核分枝杆菌拓扑异构酶IA在C端缺失的情况下会遭受能量上的困扰 |
Balthrop, D. |
PDF |
N/A |
Mycobacterial Topoisomerase IA Energetically Suffers From C-terminal Deletions |
| CRISPRoff表观遗传编辑：在人类细胞中实现可编程基因沉默，无需DNA断裂 |
Pattali, R. K. |
PDF |
N/A |
CRISPRoff epigenetic editing for programmable gene silencing in human cells without DNA breaks |
| 昆虫宿主中功能性微生物植酸酶的生物制造。 |
Retief, C. |
PDF |
N/A |
Biomanufacturing of a functional microbial phytase in an insect host. |
| 使用中尺度透析系统在PURE中实现长期蛋白质合成 |
Julia, L. R. |
PDF |
N/A |
Long-term protein synthesis with PURE in a mesoscale dialysis system |
| 跨物种全脑映射揭示了由伏隔核深部脑刺激所激活的保守且协调的神经网络 |
Feng, A. |
PDF |
N/A |
Cross-species brain-wide mapping reveals a conserved and coordinated network engaged by NAc DBS |
| 通过双向循环门控建模大脑中的注意力和绑定机制 |
Salehinajafabadi, S. |
PDF |
N/A |
Modeling Attention and Binding in the Brain through Bidirectional Recurrent Gating |
| 光感受器退化对功能性视网膜神经节细胞类型产生异质性影响 |
Dyszkant, N. |
PDF |
N/A |
Photoreceptor degeneration has heterogeneous effects on functional retinal ganglion cell types |
| 毛圆蛛（Uloborus diversus）大脑的三维免疫荧光图谱。 |
Artiushin, G. |
PDF |
N/A |
A three-dimensional immunofluorescence atlas of the brain of the hackled-orb weaver spider, Uloborus diversus. |
| 在巨细胞核中存在α-突触核蛋白聚集的前驱性突触核病模型中，运动迟缓和姿势不稳定的症状。 |
Theologidis, V. |
PDF |
N/A |
Bradykinesia and postural instability in a model of prodromal Synucleinopathy with alpha-Synuclein aggregation in the gigantocellular nuclei. |
| 非麻痹手臂的使用反映了慢性中风患者的一种习惯性行为。 |
Sporn, S. |
PDF |
N/A |
Use of the non-paretic arm reflects a habitual behaviour in chronic stroke |
| 健康供体与急性移植物抗宿主病患者T细胞反应的比较评估：定制免疫监测平台 |
Mendiratta, M. |
PDF |
N/A |
A Comparative assessment of T-Cell response of Healthy donors and Acute Graft-versus-Host-Disease Patients: Customizing immune monitoring platform |
| 从家养和野生动物中分离出的Trueperella pyogenes的基因组和代谢特征分析 |
Magossi, G. |
PDF |
N/A |
Genomic and metabolic characterization of Trueperella pyogenes isolated from domestic and wild animals |
| 冷冻电镜揭示了RNA聚合酶I在无碱基DNA损伤处暂停和停滞的顺序机制 |
Santos-Aledo, A. |
PDF |
N/A |
Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions |
| 膜结合的钙粘蛋白底物揭示了粘着连接处的肌动蛋白结构 |
Ghosh, S. |
PDF |
N/A |
Membrane-tethered cadherin substrates reveal actin architecture at adherens junctions |
| 人类肺部神经内分泌细胞对屋尘螨提取物产生反应，通过PAR-1依赖性途径释放CGRP。 |
Mann-Nuttel, R. |
PDF |
N/A |
Human pulmonary neuroendocrine cells respond to House dust mite extract with PAR-1 dependent release of CGRP |
| Rho-ROCK释放被隔离的claudin，以促进新紧密连接的快速形成 |
Cho, Y. |
PDF |
N/A |
Rho-ROCK liberates sequestered claudin for rapid de novo tight junction formation |
| 癌症中新型潘尼克斯1异构体表达增加 |
O'Donnell, B. L. |
PDF |
N/A |
Novel Pannexin 1 isoform is increased in cancer |
| 中期形成初期的早期事件稳定了新生成的双极纺锤体 |
Sim, S. |
PDF |
N/A |
Early events in midzone formation stabilize nascent bipolar spindles |
| 平衡肌动蛋白网络竞争中的有限资源 |
Guerin, C. |
PDF |
N/A |
Balancing limited resources in actin networks competition |
| 电子冷冻断层扫描揭示了纤毛内连接的结构 |
Li, S. |
PDF |
N/A |
The Structure of Cilium Inner Junctions Revealed by Electron Cryo-tomography |
| Maspin/SerpinB5是一种细胞骨架结合蛋白，能够调控上皮细胞的形态。 |
da Silva, L. |
PDF |
N/A |
Maspin/SerpinB5 is a cytoskeleton-binding protein that regulates epithelial cell shape |
| 间歇性缺氧通过依赖活性氧的机制增加H3K27乙酰化，这一过程受H3S28磷酸化的调控。 |
Nanduri, J. |
PDF |
N/A |
Reactive Oxygen species dependent increase in H3K27 acetylation by intermittent hypoxia is regulated by H3S28 phosphorylation |
| 哺乳动物肺纤维化中的神经-成纤维细胞轴 |
Ishikawa, G. |
PDF |
N/A |
A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis |
| 促性腺激素细胞具有双重起源，其中大多数在微青春期期间源自垂体干细胞。 |
Sheridan, D. |
PDF |
N/A |
Gonadotrophs have a dual origin, with most derived from pituitary stem cells during minipuberty. |
| 引入的鳟鱼阻碍了本地鱼类在极端洪水干扰后的恢复 |
Lennox, R. S. |
PDF |
N/A |
Introduced trout hinder the recovery of native fish following an extreme flood disturbance |
| 学龄前音乐性通过与节奏性相关的基因与学龄期沟通能力相关联。 |
de Hoyos, L. |
PDF |
N/A |
Preschool musicality is associated with school-age communication abilities through genes related to rhythmicity |
| VCP（一种重要的解旋酶）与去泛素酶之间不同的耦合模式 |
Vostal, L. E. |
PDF |
N/A |
Distinct modes of coupling between VCP, an essential unfoldase, and deubiquitinases |
| 在搅拌罐生物反应器中，胰腺β细胞的外泌体三步可扩展生产促进了细胞成熟及具有保留免疫调节特性的外泌体释放。 |
De Beaurepaire, L. |
PDF |
N/A |
Three-step scalable production of extracellular vesicles from pancreatic beta cells in stirred tank bioreactors promotes cell maturation and release of ectosomes with preserved immunomodulatory properties |
| BFVD - 一个预测病毒蛋白质结构的大型数据库 |
Steinegger, M. |
PDF |
N/A |
BFVD - a large repository of predicted viral protein structures |
| 利用CellMATE解锁单细胞与空间联合分析的跨模态互动 |
Jingping, Y. |
PDF |
N/A |
Unlocking cross-modal interplay of single-cell and spatial joint profiling with CellMATE |
| 估计2022/24年高致病性禽流感病毒传入美国各商业禽群的适当接触率和时间 |
Ssematimba, A. |
PDF |
N/A |
Estimating adequate contact rates and time of Highly Pathogenic Avian Influenza virus introduction into individual United States commercial poultry flocks during the 2022/24 epizootic |
| 全血生理应激引起的可逆转录组年龄变化 |
Bhak, J. |
PDF |
N/A |
Reversible Transcriptomic Age Shifts from Physiological Stress in Whole Blood |
| 肌钙蛋白-C突变谱中的钙结合亲和力：自由能计算、协同进化建模与机器学习 |
Pooja, |
PDF |
N/A |
Calcium Binding Affinity in the Mutational Landscape of Troponin-C: Free Energy Calculation, Co-evolution modeling and Machine Learning |
| 三阴性乳腺癌患者来源的异种移植模型中，线粒体的三维分析揭示了化疗治疗后线粒体网络的重塑 |
Berner, M. J. |
PDF |
N/A |
Three-dimensional analysis of mitochondria in a patient-derived xenograft model of triple negative breast cancer reveals mitochondrial network remodeling following chemotherapy treatments |
| 通过ZenoTOF技术进行的定量特异性糖蛋白质组学揭示了用于乳腺癌诊断的糖基特征 |
Yang, Y. |
PDF |
N/A |
Quantitative site-specific glycoproteomics by ZenoTOF reveals glyco-signatures for breast cancer diagnosis |
| 细胞外囊泡通过将ATP合成转运至伪足并激活整合素粘附复合物，调控淋巴管平滑肌瘤细胞的亚稳态表型。 |
Kalvala, A. K. |
PDF |
N/A |
Extracellular vesicles regulate metastable phenotypes of lymphangioleiomyomatosis cells via shuttling ATP synthesis to pseudopodia and activation of integrin adhesion complexes. |
| 在神经纤维瘤病1型中，正常组织中的与癌症无关的第二次体细胞NF1突变 |
Oliver, T. R. W. |
PDF |
N/A |
Cancer-independent, second somatic NF1 mutation of normal tissues in neurofibromatosis type 1 |
| NR2F2在早期脂肪细胞干细胞样细胞中的再激活可挽救脂肪细胞线粒体氧化 |
Das, S. |
PDF |
N/A |
NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation |
| HYCCIN2通过招募SH3P2-DRP1A驱动拟南芥胚胎细胞板形成中的膜管化 |
Hsu, Y.-w. |
PDF |
N/A |
Recruitment of SH3P2-DRP1A by HYCCIN2 Drives Membrane Tubulation in Arabidopsis Embryonic Cell Plate Formation |
| 雌激素受体α介导的PRICKLE1抑制作用破坏了REST的稳定性，并促进了子宫肌瘤的发病机制。 |
McWilliams, M. M. |
PDF |
N/A |
Estrogen receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis |
| Osterix通过靶向连接蛋白43促进骨细胞间的通讯 |
wu, z. |
PDF |
N/A |
Osterix Facilitates Osteocytic Communication by Targeting Connexin43 |
| SAF-A SAP结构域在X染色体失活、转录、剪接和细胞增殖中的作用 |
Sharp, J. A. |
PDF |
N/A |
Role of the SAF-A SAP domain in X inactivation, transcription, splicing, and cell proliferation |
| 突触前神经元是线粒体自噬的驿站，能防止轴突退化。 |
Lam, W. K. |
PDF |
N/A |
Presynapses are mitophagy pit stops that prevent axon degeneration |
| 力量变异性可能是半球中风幸存者运动障碍的潜在生物标志物。 |
Shi, F. |
PDF |
N/A |
Force variability is a potential biomarker of motor impairment in hemispheric stroke survivors |
| 帕金森病患者中有一小部分人的骨骼肌出现了线粒体复合物I缺陷。 |
Kverneng, S. U. |
PDF |
N/A |
Mitochondrial complex I deficiency occurs in skeletal muscle of a subgroup of individuals with Parkinson's disease |