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BioRxiv 2024-09-13 Papers

标题 作者 PDF链接 代码仓库 Title
大脑状态和皮层层特异性机制在感知阈值下的作用 Morton, M. P. PDF N/A Brain state and cortical layer-specific mechanisms underlying perception at threshold
跨多个脓肿分枝杆菌分离株的转座子测序揭示了菌株间显著的功能基因组多样性 Akusobi, C. PDF N/A Transposon-sequencing across multiple Mycobacterium abscessus isolates reveals significant functional genomic diversity among strains
Kisspeptin纤维及其受体分布分析表明其在中枢感觉处理和行为状态控制中可能发挥的作用。 Zhang, L. PDF N/A Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control
核篮蛋白调控芽殖酵母中核孔复合体的分布和移动性 Zsok, J. PDF N/A Nuclear basket proteins regulate the distribution and mobility of nuclear pore complexes in budding yeast
呼吸与觉醒之间的动态联系 Kluger, D. S. PDF N/A A dynamic link between respiration and arousal
Hill型方程揭示了由p53脉冲引导的目标蛋白质表达的调控原理。 Shi, X. PDF N/A The Hill-type equation reveals the regulatory principle of target protein expression led by p53 pulsing
伏隔核多巴胺释放反映了工具性学习过程中的贝叶斯推理 Qu, A. J. PDF N/A Nucleus accumbens dopamine release reflects Bayesian inference during instrumental learning
在转移性微环境中异常激活的伤口愈合程序促进了骨肉瘤细胞在肺部的定植。 Reinecke, J. B. PDF N/A Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells
高参数蛋白图谱揭示了早期发育中人类肺的空间组织结构 Sariyar, S. PDF N/A High-parametric protein maps reveal the spatial organization in early-developing human lung
WildPose:一种长距离3D野生动物运动捕捉系统 Muramatsu, N. PDF N/A WildPose: A Long-Range 3D wildlife motion capture system
直接耦合分析与注意力机制 Caredda, F. PDF N/A Direct Coupling Analysis and The Attention Mechanism
开发用于研究合作行为的自动化拉取装置(MarmoAAP) Meisner, O. C. PDF N/A Development of a Marmoset Apparatus for Automated Pulling (MarmoAAP) to Study Cooperative Behaviors
CD44促进了在空气介导的细胞间信号传导中的粘附相互作用。 Bowman, R. L. PDF N/A CD44 facilitates adhesive interactions in airineme-mediated intercellular signaling
小鼠胚胎发育过程中多条件和多模态时间剖面推断 Zhang, R. PDF N/A Multi-condition and multi-modal temporal profile inference during mouse embryonic development
Vps5-Vps17 SNX-BAR蛋白与Retromer组装的分子基础 Chen, K.-E. PDF N/A Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer
moPepGen:快速全面鉴定非规范肽段 Zhu, C. PDF N/A moPepGen: Rapid and Comprehensive Identification of Non-canonical Peptides
理解先前经验对疼痛感知和神经性疼痛影响的计算框架 Ramne, M. PDF N/A A Computational Framework for Understanding the Impact of Prior Experiences on Pain Perception and Neuropathic Pain
通过微调扩散模型精确生成固有无序蛋白质的构象集合 Zhu, J. PDF N/A Precise Generation of Conformational Ensembles for Intrinsically Disordered Proteins via Fine-tuned Diffusion Models
96孔聚丙烯酰胺凝胶用于电泳和Western印迹 Birtwistle, M. R. PDF N/A A 96-Well Polyacrylamide Gel for Electrophoresis and Western Blotting
性别分化与性二态性的共同演化 Lesaffre, T. PDF N/A The joint evolution of separate sexes and sexual dimorphism
揭示基因组复杂性:基因组图结构分析与优化变异检测工作流程的框架 Kamaraj, V. PDF N/A Unveiling Genomic Complexity: A Framework for Genome Graph Structural Analysis and Optimised Variant Calling Workflows
果蝇神经肌肉接头处的外周胶质细胞和神经元共同调节活动诱导的突触重塑 Chang, Y.-C. PDF N/A Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the Drosophila neuromuscular junction
微生物代谢物引导的CAR T细胞工程通过表观遗传-代谢交叉对话增强抗肿瘤免疫 Staudt, S. PDF N/A Microbial metabolite-guided CAR T cell engineering enhances anti-tumor immunity via epigenetic-metabolic crosstalk
综合多模型分析肠道炎症揭示了临床前和临床炎症性肠病的关键分子特征 Gonzalez Acera, M. PDF N/A Integrated multi-model analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD
训练在动物园中对声音学习实验缺乏经验的港海豹参与发声学习实验 Duengen, D. PDF N/A Training Experimentally Naive Harbor Seals to Participate in Vocal Learning Experiments in a Zoo
编排不可能的化学:B12依赖型甲硫氨酸合成酶催化编排的结构快照 Mendoza, J. PDF N/A Orchestrating Improbable Chemistries: Structural Snapshots of B12-Dependent Methionine Synthase's Catalytic Choreography
胆碱能信号通过不同方式调节鸣禽的鸣唱前运动回路,以稳定鸣唱。 Xu, N. PDF N/A Cholinergic signaling differentially regulates song premotor circuits to stabilize songs in songbirds
IL-6和IL-27负向调控与淋巴驱动性滑膜炎相关的CRTAM表达CD4+ T细胞。 Derrac Soria, A. PDF N/A IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis.
人类和蝙蝠基因组在COSMIC突变特征下的稳健性 Song, J.-H. PDF N/A Human and bats genome robustness under COSMIC mutational signatures
通过拓扑约束分子生成模型发现新型喹啉类木瓜蛋白酶样蛋白酶抑制剂用于COVID-19 Shang, J. PDF N/A Discovery of novel quinoline papain-like protease inhibitors for COVID-19 through topology constrained molecular generative model
HIV Vpr激活了一种核仁特异性的ATR通路,以降解核仁应激传感器CCDC137 Nisson, K. A. PDF N/A HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137
解锁隐藏噬菌体多样性,以完成BASEL收藏,系统探索噬菌体-宿主相互作用 Humolli, D. PDF N/A Unlocking hidden phage diversity to complete the BASEL collection for systematic exploration of phage-host interactions
炎症通过重塑骨髓微环境中的特定区域来干扰造血功能。 Swann, J. W. PDF N/A Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche
单层和双层中脂质动力学精确建模的挑战 Tempra, C. PDF N/A Challenges in the Accurate Modelling of Lipid Dynamics in Monolayers and Bilayers
ADPKD 变异体在 PKD2 孔螺旋中导致门结构塌陷和不同形式的通道功能障碍。 Palomero, O. E. PDF N/A ADPKD variants in the PKD2 pore helix cause structural collapse of the gate and distinct forms of channel dysfunction.
综合分子动力学模拟解析交联数据,揭示线粒体蛋白质分布 Schuhmann, F. PDF N/A Integrative Molecular Dynamics Simulations Untangle Cross-Linking Data to Unveil Mitochondrial Protein Distributions
G3BP1通过负调控MYD88-ARNO-ARF6信号通路维持血管内皮屏障的完整性。 Wen, B. PDF N/A G3BP1 Maintains Vascular Endothelial Barrier Integrity by Negatively Regulating the MYD88-ARNO-ARF6 Signaling Pathway
生长素高亮荧光的发展 Aoyama, T. PDF N/A Development of bright fluorescent auxin
HCV感染中病毒适应性和适应性免疫反应的时间动态 Walker, M. R. PDF N/A Temporal dynamics of viral fitness and the adaptive immune response in HCV infection
系统综述与荟萃分析:欧盟地区Hyalomma marginatum蜱的脊椎动物宿主 Bah, M. T. PDF N/A Systematic review and meta-analysis of Hyalomma marginatum vertebrate hosts in the EU
欺凌与早期大脑发育:一项从青少年到成年早期的纵向结构磁共振成像研究 Connaughton, M. PDF N/A Bullying and Early Brain Development: A Longitudinal Structural Magnetic Resonance Imaging Study from Adolescence to Early Adulthood
阴道微生物群作为早产预测指标:一项观察性队列研究 Lesimple, L. PDF N/A Vaginal microbiota as a predictor of preterm birth: an observational cohort study
针对牛繁殖失败相关病原体的靶向综合下一代测序面板,实现病原体的同步检测 Periyasamy, D. PDF N/A Targeted syndromic next-generation sequencing panel for simultaneous detection of pathogens associated with bovine reproductive failure
不同用途温带玉米杂交种在不同环境下的核权重和源/汇比确定 Chazarreta, Y. D. PDF N/A Kernel weight and source/sink ratio determination of temperate maize hybrids with different end uses under contrasting environments
念珠菌(Candida albicans)与粪肠球菌(Enterococcus faecalis)之间的跨物种协同宿主细胞损伤 Kapitan, M. PDF N/A Synergistic cross-kingdom host cell damage between Candida albicans and Enterococcus faecalis
在pre-mRNA的3'-非翻译区,剪接位点的异质性调控基因表达 Shaji, F. PDF N/A Cleavage site heterogeneity at the pre-mRNA 3'-untranslated region regulates gene expression
巨噬细胞衍生的RNAseT2通过SLK/N-WASP/肌动蛋白束促进肌肉干细胞融合 Weiss-Gayet, M. PDF N/A Macrophage-derived RNAseT2 stimulates muscle stem cell fusion via SLK/N-WASP/actin bundling
连接组上的扩散小波:利用图扩散小波定位介导结构-功能映射的扩散源 Jain, C. S. PDF N/A Diffusion Wavelets on Connectome: Localizing the Sources of Diffusion Mediating Structure-Function Mapping Using Graph Diffusion Wavelets
DRED:一个综合性的与重复扩展疾病相关的基因数据库 Shi, Q. PDF N/A DRED: A Comprehensive Database of Genes Related to Repeat Expansion Diseases
肝细胞中的胰高血糖素受体(GCGR)对于结构上与双重GCGR/GLP1R激动剂survodutide相关的类似物在体重减轻方面的卓越效果是必需的。 Long, F. PDF N/A Hepatic GCGR is required for the superior weight loss effects of a structurally related analogue of the dual GCGR/GLP1R agonist survodutide
受控检索依赖于语义控制区域与视觉皮层之间的定向交互作用:来自振荡动力学的MEG证据 Eisenhauer, S. PDF N/A Controlled retrieval relies on directed interactions between semantic control regions and visual cortex: MEG evidence from oscillatory dynamics
肩胛间棕色脂肪组织的交感神经支配并非雄性饮食诱导肥胖大鼠中OT引发体重增加和脂肪减少的主要介质。 Edwards, M. M. PDF N/A Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of OT-elicited reductions of body weight gain and adiposity in male diet-induced obese rats
RBBP5通过表观遗传调控全局蛋白质稳态动力学,确保哺乳动物机体健康 Kubra, S. PDF N/A Epigenetic regulation of global proteostasis dynamics by RBBP5 ensures mammalian organismal health
高尔基体相关微管交联蛋白MTCL2促进小脑颗粒神经元树突的多极延伸。 Minekawa, M. PDF N/A The Golgi-associated microtubule cross-linking protein MTCL2 promotes the multipolar extension of dendrites in cerebellar granule neurons.
细胞质中的核糖体搭乘线粒体前往树突 Renken, C. J. PDF N/A Cytoplasmic ribosomes hitchhike on mitochondria to dendrites
早期将初级肌管与次级肌管及成体肌肉干细胞分隔开来。 Toulouse, G. PDF N/A Early lineage segregation of primary myotubes from secondary myotubes and adult muscle stem cells.
水牛在发情期和间情期之间无细胞唾液miRNA谱的比较 CHANDEL, R. PDF N/A Comparative cell free salivary miRNA profile in Bubalus bubalis between diestrus and estrus stages
对野化与本地捕食者组合的增补、可替代及拮抗性猎物反应 St. Juliana, J. R. PDF N/A Additive, substitutable, and antagonistic prey responses to feral and native predator combinations
一种通过计算指导的方法来提高VHH结合剂的表达 OZDEMIR, E. S. PDF N/A A computationally guided approach to improve expression of VHH binders
具有可逆热离子交联的3D水凝胶功能性人唾液腺泡细胞球状体的扩展 Munguia-Lopez, J. G. PDF N/A Expansion of functional human salivary acinar cell spheroids with reversible thermo-ionically crosslinked 3D hydrogels
染色质三色单分子定位显微镜 Acosta, N. PDF N/A Three-color single-molecule localization microscopy in chromatin
EmbSAM:用于快速发育胚胎图像的细胞边界定位与分割任意模型 Zhao, C. PDF N/A EmbSAM: Cell boundary localization and Segment Anything Model for fast images of developing embryos
CNValidatron,利用计算机视觉实现CNV调用的自动化验证 Montalbano, S. PDF N/A CNValidatron, automated validation of CNV calls using computer vision
bayesReact:表达耦合的调控基序分析在癌症和单细胞水平检测微RNA活性 Rasmussen, A. M. PDF N/A bayesReact: Expression-coupled regulatory motif analysis detects microRNA activity in cancer and at the single cell level
niiv: 快速自监督神经隐式各向同性体积重建 Troidl, J. PDF N/A niiv: Fast Self-supervised Neural ImplicitIsotropic Volume Reconstruction
从谱系追踪数据推断细胞分化图谱 Sashittal, P. PDF N/A Inferring cell differentiation maps from lineage tracing data
Montijano-Bergues-Bory-Gompertz随机模型中未受干扰肿瘤生长的参数估计 Bonilla-Capilla, B. PDF N/A Parameter estimation in the Montijano-Bergues-Bory-Gompertz stochastic model for unperturbed tumor growth
白血病衍生的apelin选择内皮龛克隆以促进肿瘤发生 Baron, C. S. PDF N/A Leukemia-derived apelin selects endothelial niche clones to promote tumorigenesis
PROX1对细胞命运可塑性的主动抑制保障了肝细胞的特性,并防止了肝癌的发生。 Lim, B. PDF N/A Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis
顺序使用ATR和PARP抑制剂克服胰腺导管腺癌中获得的DNA损伤剂抗性 Herbert, K. J. PDF N/A Sequential ATR and PARP Inhibition Overcomes Acquired DNA Damaging Agent Resistance in Pancreatic Ductal Adenocarcinoma
GCN2在整合应激反应之外的作用:防止过度核糖体生物合成和mRNA翻译 Roman-Trufero, M. PDF N/A An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
线粒体代谢是结直肠癌化疗敏感性的关键决定因素 Moss, D. Y. PDF N/A Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer
梅克尔细胞癌衍生的巨噬细胞迁移抑制因子(MIF)可能促进慢性淋巴细胞白血病的持续存在。 Alencar, G. F. PDF N/A Merkel cell carcinoma-derived macrophage migration inhibitory factor (MIF) may promote persistence of Chronic Lymphocytic Leukemia
进化获得了一种原始的光依赖性核重定位现象,这种现象在地钱(Marchantia polymorpha)中被观察到。 Iwabuchi, K. PDF N/A Evolutionary acquisition of a primitive light-dependent nuclear relocation in Marchantia polymorpha
抗体亲和力的提高及利用PURE核糖体展示和微生物分泌系统 Kihara, M. PDF N/A Improvement of Antibody Affinity and Using PURE Ribosome Display and Microbial Secretion System
RoCi - 基于滚环复制的单步多拷贝整合系统 Antsotegi-Uskola, M. PDF N/A RoCi - A Single Step Multi-Copy Integration System Based on Rolling-Circle Replication
基于BEN的预测建模(BPM)进行表型预测 Song, D. PDF N/A Phenotype Prediction Using BEN-Based Predictive Modeling (BPM)
斑马鱼幼体感觉运动反应的发育:野生型与GCaMP6s转基因品系的比较 Caperaa, M. PDF N/A Development of sensorimotor responses in larval zebrafish: a comparison between wild-type and GCaMP6s transgenic line
利用结构方程模型预测静态和动态听觉图形-背景分析中的噪音中言语能力 Guo, X. PDF N/A Predicting speech-in-noise ability with static and dynamic auditory figure-ground analysis using structural equation modelling
灵长类上丘对暗对比的微扫视前敏感性增强更强 Wu, W. PDF N/A Stronger premicrosaccadic sensitivity enhancement for dark contrasts in the primate superior colliculus
PSEN1突变通过破坏受调控的细胞内蛋白水解作用,使家族性阿尔茨海默病中的星形胶质细胞模型易发炎症。 Ziff, O. J. PDF N/A Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis
在海马体循环网络模型中,条形码活动能够实现高效的记忆绑定。 Fang, C. PDF N/A Barcode activity in a recurrent network model of the hippocampus enables efficient memory binding
M3毒蕈碱乙酰胆碱受体对人类记忆辅助性T细胞炎症特征的调节作用 Gholizadeh, F. PDF N/A Modulatory Effects of M3 Muscarinic Acetylcholine Receptor on Inflammatory Profiles of Human Memory T Helper Cells
非经典白介素-22受体信号在真菌免疫监视期间重塑黏膜屏障 Millet, N. PDF N/A Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance
枯萎的野花和沮丧的蜜蜂:气候变化威胁美国州象征 Ge, X. PDF N/A Wilting Wildflowers and Bummed-Out Bees: Climate Change Threatens U.S. State Symbols
在多菌株接种中,苜蓿共生基因的突变为根瘤菌中自然发生的遗传变异创造了复杂的选择环境。 Guha, S. PDF N/A In multi-strain inoculations, mutation of Medicago symbiosis genes creates a complex selective landscape for naturally-occurring genetic variation in rhizobia
注意极地太阳:尽管空气温度相对较低,太阳辐射仍频繁引发繁殖中的王企鹅的热应激。 Noiret, A. PDF N/A Mind the polar sun: Solar radiations trigger frequent heat stress in breeding king penguins, despite relatively cool air temperatures.
胰腺疾病风险相关增强子的预测优先级 Wang, L. PDF N/A Predictive Prioritization of Enhancers Associated with Pancreas Disease Risk
一种占卜鼠尾草(Salvia divinorum)的染色体级别参考基因组为萨维诺林A的生物合成提供了深入见解。 Ford, S. A. PDF N/A A chromosome level reference genome of Diviners sage (Salvia divinorum) provides insight into salvinorin A biosynthesis
手势交流的特异性:巴巴利猕猴(Macaca sylvanus)拍手行为的个案研究 Bosshard, T. C. PDF N/A Idiosyncrasy in gestural communication: a case study of hand-clapping in a Barbary macaque (Macaca sylvanus)
尼古丁与阿尔法辐射诱导的DNA损伤相互作用,这可能有助于在人类肺上皮细胞中进行错误的修复。 Boroumand, N. PDF N/A Nicotine interacts with DNA lesions induced by alpha radiation which may contribute to erroneous repair in human lung epithelial cells
喷墨打印的石墨烯多电极阵列:一种适用于体外心脏电生理学的可及平台 Lumpuy-Castillo, J. PDF N/A Inkjet-printed graphene multielectrode arrays: an accessible platform for in vitro cardiac electrophysiology
Novae:一种基于图的空间转录组学数据基础模型 Blampey, Q. PDF N/A Novae: a graph-based foundation model for spatial transcriptomics data
基于系统发育的代表性变异体选择与Navargator:使用两个免疫研究中的体液交叉反应数据验证原理 Curran, D. M. PDF N/A Phylogeny-based selection of representative variants with Navargator: Proof of principle using humoral cross-reactivity data from two immunization studies
G2PDeep-v2:一种基于网络的深度学习框架,用于利用多组学数据进行表型预测和生物标志物发现 Zeng, S. PDF N/A G2PDeep-v2: a web-based deep-learning framework for phenotype prediction and biomarker discovery using multi-omics data
BEGAN:基于玻尔兹曼加权数据增强的增强型GAN用于昆虫信息素受体中的分子设计 Dai, J. PDF N/A BEGAN: Boltzmann-Reweighted Data Augmentation for Enhanced GAN-Based Molecule Design in Insect Pheromone Receptors
Pyjacker识别出急性髓系白血病中的增强子劫持事件,包括通过删除7q激活MNX1。 Sollier, E. PDF N/A Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q
DNA损伤应答缺陷增强神经母细胞瘤进展并提高对PARP和ATR联合抑制的敏感性 Hayes, M. N. PDF N/A DNA Damage Response Deficiency Enhances Neuroblastoma Progression and Sensitivity to Combination PARP and ATR Inhibition
高效发现非底物型共价抑制剂及其与S-腺苷甲硫氨酸脱羧酶的结构-活性关系分析 Ai, Y. PDF N/A High-efficiency discovery and structure-activity-relationship analysis of non-substrate-based covalent inhibitors of S-adenosylmethionine decarboxylase
小鼠远端输卵管中多纤毛细胞的与衰老相关的空泡化反映了独特的细胞身份和管腔微环境。 Harwalkar, K. PDF N/A Aging-associated vacuolation of multi-ciliated cells in the distal mouse oviduct reflects unique cell identity and luminal microenvironment
霜霉病菌效应蛋白HaRxL106与转录因子BIM1相互作用,改变植物生长、油菜素内酯信号传导及对病原体的易感性。 Bogino, M. F. PDF N/A Downy mildew effector HaRxL106 interacts with the transcription factor BIM1 altering plant growth, BR signaling and susceptibility to pathogens
拟南芥组蛋白H3K4me3结合的ALFIN样蛋白介导组蛋白H2A的泛素化,并协调多种染色质修饰。 Su, X.-M. PDF N/A The Arabidopsis histone H3K4me3-binding ALFIN-like proteins mediate histone H2A ubiquitination and coordinate diverse chromatin modifications
利用大型语言模型进行代谢工程设计 Li, X. PDF N/A Leveraging large language models for metabolic engineering design
鱼类中的微量元素:生物累积评估及其相关健康风险。 Naz, S. PDF N/A Trace Elements in Fish: Assessment of bioaccumulation and associated health risks.
禁食对热应激肉鸡的影响:第一部分——生长性能、肉质、肠道组织形态学和微生物反应 Ahmed, T. PDF N/A Effects of fasting on heat-stressed broiler chickens: part I- growth performance, meat quality, gut histomorphological and microbial responses
神经营养因子artemin及其受体GFRα3通过离子通道TRPM8介导偏头痛样疼痛。 Yang, C. PDF N/A The neurotrophin artemin and its receptor GFRα3 mediate migraine-like pain via the ion channel TRPM8
情境性恐惧表达的性别差异与内侧前额叶皮层活动的改变有关 Vazquez, K. PDF N/A Sex differences in contextual fear expression are associated with altered medial prefrontal cortex activity
背侧下丘中听觉空间的人口编码在双耳线索改变的情况下仍然存在 Rogalla, M. M. PDF N/A Population coding of auditory space in the dorsal inferior colliculus persists with altered binaural cues
多种感觉剥夺对内侧内嗅皮层空间编码细胞的不同影响 Tian, J. PDF N/A Differential Impact of Multiple Sensory Deprivation on Spatial-coding Cells in Medial Entorhinal Cortex
爆裂放电通过电感觉神经群体优化了自然通信信号的不变编码 Metzen, M. G. PDF N/A Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations
针对α-突触核蛋白的病毒编码单链抗体片段可保护小鼠免受突触核蛋白病模型中的运动障碍和神经病理学损害 Castonguay, A.-M. PDF N/A Virally encoded single-chain antibody fragments targeting alpha-synuclein protect against motor impairments and neuropathology in a mouse model of synucleinopathy
IL-1b介导的角膜上皮细胞免疫代谢适应 Sanches, J. M. PDF N/A IL-1b-mediated Immunometabolic Adaptation in Corneal Epithelial Cells
脑膜炎球菌疫苗Bexsero能引发强大的细胞免疫反应,这种反应针对的是但并不总是能保护小鼠在阴道感染期间免受淋病奈瑟菌的侵害。 Zeppa, J. J. PDF N/A Meningococcal vaccine Bexsero elicits a robust cellular immune response that targets but is not consistently protective against Neisseria gonorrhoeae during murine vaginal infection
IFT和BBSome蛋白对于墨西哥利什曼原虫的致病性是必需的,但鞭毛运动是非必需的。 Beneke, T. PDF N/A IFT and BBSome proteins are required for Leishmania mexicana pathogenicity, but flagellar motility is dispensable
对小农户水稻种植者的成本效益分析显示,现有的施肥方式严重损害了他们的收入。 Chen, J. PDF N/A Cost-benefit analysis across smallholder rice farmers reveals that existing fertilization practices severely compromise their income
化石多样化速率的表观时间缩放是由采样偏差引起的。 Reijenga, B. R. PDF N/A Apparent timescaling of fossil diversification rates is caused by sampling bias
洞穴作为物种泵:关键创新、隔离与周期性基因渗入驱动动态喀斯特景观中世界最大洞穴鱼辐射 Mao, T. PDF N/A Caves as species pumps: key innovations, isolation, and periodic introgression drive the world's largest cavefish radiation in a dynamic karstic landscape
一种新生F-box基因通过选择性降解磷酸葡萄糖变位酶阻断种间杂交中的基因流动 Xie, D. PDF N/A A Newborn F-box Gene Blocks Gene Flow by Selectively Degrading Phosphoglucomutase in Species Hybrids
强选择,但低重复性:温度对适应性基因组预测的特定影响 Rego, A. PDF N/A Strong Selection, but low repeatability: Temperature-specific effects on genomic predictions of adaptation
性染色体上癌症基因的体细胞进化 Marco, A. PDF N/A Somatic evolution of cancer genes in sex chromosomes
单倍体型解析基因组为研究双壳类基因组多样性的起源和功能提供了见解 Liu, S. PDF N/A Haplotype-resolved genomes provide insights into the origin and function of genome diversity in bivalves
METTL3通过Akt/mTOR通路调节辐射诱导的心脏纤维化 Gu, X.-s. PDF N/A METTL3 Modulates Radiation-Induced Cardiac Fibrosis via the Akt/mTOR Pathway
通过抑制帽依赖性起始,NRF2翻译阻断增强了淋巴瘤细胞对铁死亡和CAR-T免疫疗法的敏感性。 Manara, P. PDF N/A NRF2 translation block by inhibition of cap-dependent initiation sensitizes lymphoma cells to ferroptosis and CAR-T immunotherapy
对拟南芥中影响叶片毛状体发育和表皮金属积累的基因进行全基因组关联筛选 Bezvoda, R. PDF N/A A genome-wide association screen for genes affecting leaf trichome development and epidermal metal accumulation in Arabidopsis
程序性细胞死亡和气孔密度调控花药在环境湿度变化下的开裂 Kampova, A. PDF N/A Programmed cell death and stomatal density regulate anther opening in response to ambient humidity
乙烯通过ERF5-褪黑素-ERF104途径增强VvMYB14表达,从而调节葡萄籽中的苯丙烷途径 Gao, S. PDF N/A Ethylene Modulates the Phenylpropanoid Pathway by Enhancing VvMYB14 Expression via the ERF5-Melatonin-ERF104 Pathway in Grape Seeds
一种内源性多肽PEP2调节拟南芥中的铁缺乏信号传导和根系生长。 Shikha, D. PDF N/A An endogenous peptide PEP2 modulates Iron-deficiency signalling and root growth in Arabidopsis.
重新审视Vellozia Vand.的细胞遗传学:KLN1的免疫定位阐明了该属的染色体数目 Braz, G. T. PDF N/A Revisiting the cytogenetics of Vellozia Vand.: immunolocalization of KLN1 elucidates the chromosome number for the genus
气候大脑 - 问卷、任务与神经影像数据集 Zaremba, D. A. PDF N/A CLIMATE BRAIN - Questionnaires, Tasks and the Neuroimaging Dataset
中性粒细胞NADPH氧化酶打破炎症IL-1β/IL-17A循环,以增强呼吸道病毒感染期间的病原体清除。 Sofoluwe, A. PDF N/A Neutrophil NADPH oxidase breaks the inflammatory IL-1beta/IL-17A circuit to enhance pathogen clearance during respiratory virus infections.
孤儿核受体NR4A3对于驻留记忆CD8+ T细胞的生成并非必需。 Odagiu, L. PDF N/A The orphan nuclear receptor NR4A3 is dispensable for resident memory CD8+ T cell generation
通过抑制髓源性抑制细胞中的PI3K-gamma信号通路,预防手术引起的免疫抑制和转移。 Angka, L. PDF N/A Preventing surgery induced immune suppression and metastases by inhibiting PI3K-gamma signalling in Myeloid-Derived Suppressor Cells.
IL-34通过赋予调节性T细胞新的非经典功能,在神经炎症期间保护脑屏障的完整性。 Van Hoecke, L. PDF N/A IL-34 empowers regulatory T cells with novel non-canonical function to safeguard brain barrier integrity during neuro-inflammation.
检测粪菌移植后的微生物定植:利用安慰剂测序和培养富集的宏基因组学方法从噪声中筛选信号 Shekarriz, S. PDF N/A Detecting microbial engraftment after FMT: sorting signals from noise using placebo sequencing and culture-enriched metagenomics
对入侵的大黄蜂(Bombus terrestris)进行全景观的宏条形码分析显示,肠道微生物组与花粉微生物组之间存在相互作用。 Haque, S. PDF N/A Landscape-wide metabarcoding of the invasive bumblebee (Bombus terrestris) shows interactions among the gut microbiome and pollenbiome
在野生和圈养的狐猴中,口腔微生物群的恢复力和头发微生物群在宿主环境中的不稳定性 Burten, R. B. PDF N/A The resilience of the oral microbiome and lability of the hair microbiome across host environments in wild and captive lemurs
欧洲旧石器时代晚期人口对气候变化的反应 Schmidt, I. PDF N/A Demographic responses to climatic changes during the Final Palaeolithic in Europe
氮对沙丘石楠生态系统中Calluna vulgaris和Avenella flexuosa生长的影响:竞争与频率依赖性 Damgaard, C. PDF N/A The effect of nitrogen on the growth of Calluna vulgaris and Avenella flexuosa in a dune heath ecosystem: competition and frequency-dependence
中欧永久农业的作物生产力介于有机农业和传统农业之间。 Reiff, J. PDF N/A Crop productivity of Central European Permaculture is within the range of organic and conventional agriculture.
上下文和性别依赖的父本性成功与后代病原体抵抗力之间的联系 Liao, A. PDF N/A Context- and sex-dependent links between sire sexual success and offspring pathogen resistance
饥饿时间决定其对果蝇雌性感染易感性的影响,与宿主进化历史无关 Basu, A. PDF N/A Timing of starvation determines its effects on susceptibility to infection in Drosophila melanogaster females independent of host evolutionary history
高分辨率离子迁移分离与信使标记红外光谱联用平台的发展及其在精准结构表征中的应用 Harrilal, C. PDF N/A Development of a Platform for High-Resolution Ion Mobility Separations Coupled with Messenger Tagging Infrared Spectroscopy for High-Precision Structural Characterizations
genomesizeR:一个用于基因组大小预测的R包 Mercier, C. PDF N/A genomesizeR: An R package for genome size prediction
番茄和茄子幼苗茎部因感染Ralstonia pseudosolanacearum F1C1而出现的软化和半透明形态特征 Bhuyan, S. PDF N/A Morphology of softening and translucency in the stems of tomato and eggplant seedlings due to infection by Ralstonia pseudosolanacearum F1C1
利用植硅体分析区分野生和驯化埃塞俄比亚香蕉(芭蕉科) Castillo Cobo, C. PDF N/A Differentiating wild and domesticated enset (Musaceae) using phytolith analysis
ElixirSeeker:一种利用注意力驱动融合分子指纹的机器学习框架,用于发现抗衰老化合物 Pan, Y. PDF N/A ElixirSeeker: A Machine Learning Framework Utilizing Attention-Driven Fusion of Molecular Fingerprints for the Discovery of Anti-Aging Compounds
一种可扩展的代谢组学绝对定量方法 Ferro, L. S. PDF N/A A scalable approach to absolute quantitation in metabolomics
蝙蝠听觉中脑中发声自我监测的神经表征 Ye, H. PDF N/A Neural representation of vocalization self-monitoring in the bat auditory midbrain
LM11a-31抑制p75神经营养素受体(p75NTR)的切割,并在帕金森病细胞培养模型中具有神经保护作用。 Pokharel, P. V. PDF N/A LM11a-31 Inhibits p75 Neurotrophin Receptor (p75NTR) Cleavage and is Neuroprotective in a Cell Culture Model of Parkinson's Disease.
超越免疫:疟原虫对蚊子代谢途径调控的转录组全景图 Garcia-Longoria, L. PDF N/A Beyond immunity: a transcriptomic landscape of Plasmodium's modulation of mosquito metabolic pathways
将濒危的萨瓦纳树种Firmina major的基因组组装起来,这种树种是中国特有的。 Yang, J. PDF N/A Genome assembly of Firmina major, an endangered savanna tree species endemic to China
START域从单一网络结构中生成特定旁系同源基因的调控网络 Holub, A. S. PDF N/A START domains generate paralog-specific regulons from a single network architecture
对四种小鼠器官中基因、长链非编码RNA和转座子转录模式的调查揭示了共享和器官特异性的性别偏倚调控 Zhuang, Q. K.-W. PDF N/A Survey of gene, lncRNA and transposon transcription patterns in four mouse organs highlights shared and organ-specific sex-biased regulation
流感人类T细胞反应的目标大多在H5N1中保持保守。 Sidney, J. PDF N/A Targets of influenza Human T cell response are mostly conserved in H5N1
宿主年龄和营养如何影响专性共生菌与兼性共生菌的密度调控?来自采采蝇的启示 Whittle, M. PDF N/A How does host age and nutrition affect density regulation of obligate versus facultative bacterial symbionts? Insights from the tsetse fly
壳外世界:温度如何塑造两种近缘海洋蜗牛的遗传变异 Wuitchik, D. M. PDF N/A Outside your shell: how temperature shapes genetic variation in two species of congeneric marine snails
用于鲑鱼生态系统监测的eDNA采样系统 Deeg, C. M. PDF N/A eDNA sampling systems for salmon ecosystem monitoring
实现具有生理运动补偿的真实三维扩散成像 Wang, Y. PDF N/A Towards genuine three-dimensional diffusion imaging with physiological motion compensation
血液-脑屏障类器官的高级组织技术作为药物开发中的高通量毒性检测手段 Bell, L. PDF N/A Advanced Tissue Technologies of Blood-Brain Barrier Organoids as High Throughput Toxicity Readouts in Drug Development
静息状态脑电图固有神经时间尺度的重测信度 Tang, X. PDF N/A Test-retest reliability of resting-state EEG intrinsic neural timescales
在7特斯拉磁场下使用31P-MRS对小鼠大脑中肌酸激酶动力学进行体内定量研究 Tachrount, M. PDF N/A In vivo quantification of creatine kinase kinetics in mouse brain using 31P-MRS at 7 Tesla
从第一性原理理解髓鞘化比率,其推导、用途及伪影 Gow, A. PDF N/A Understanding The Myelin g ratio From First Principles, Its Derivation, Uses And Artifacts
背侧中缝5-羟色胺神经元内在动力学对长程输入的功能性分离 Lynn, M. B. PDF N/A Functional separation of long-range inputs by intrinsic dynamics of dorsal raphe 5-HT neurons
呼吸对反应速度和准确性产生了系统性的时间滞后影响。 Harting, C. PDF N/A Respiration shapes response speed and accuracy with a systematic time lag
利用具有图案化亲水斑块的双亲性微粒实现可调的皮升级液滴形成 Song, X. PDF N/A Tunable picoliter-scale dropicle formation using amphiphilic microparticles with patterned hydrophilic patches
Doblin:从DNA条形码时间序列中推断占优势的克隆谱系 Serohijos, A. PDF N/A Doblin: Inferring dominant clonal lineages from DNA barcoding time-series
RNAi药物在快速分裂细胞中的结构-沉默持续时间关系 Kremer, A. PDF N/A Structure - silencing duration relationships in RNAi medicines in rapidly dividing cells
Mouse-Geneformer:一种用于小鼠单细胞转录组的深度学习模型及其跨物种应用 Shigenobu, S. PDF N/A Mouse-Geneformer: A Deep Learning Model for Mouse Single-Cell Transcriptome and Its Cross-Species Utility
时间生物学节律对中枢神经系统中特定部位和细胞的miRNA和mRNA基因及网络的调控 Zacharias, A. M. PDF N/A Chronobiological rhythms control of site- and cell-specific miRNA and mRNA genes and networks across the central nervous system
单价XBB.1.5 mRNA疫苗比二价WT/BA.5 mRNA疫苗更能持久且协调地引发对SARS-CoV-2刺突蛋白的抗体反应。 Barouch, S. E. PDF N/A Monovalent XBB.1.5 mRNA Vaccine Recalls a More Durable and Coordinated Antibody Response to SARS-CoV-2 Spike than the Bivalent WT/BA.5 mRNA Vaccine
人表面活性蛋白A变异体的差异性免疫调节决定了SARS-CoV-2诱导的肺病严重程度 Jacob, I. B. PDF N/A Differential Immunoregulation by Human Surfactant Protein A Variants Determines Severity of SARS-CoV-2-induced Lung Disease
细菌基因组编码的ParMs Ali, S. PDF N/A Bacterial genome encoded ParMs
鉴定出一种调节免疫反应的真菌抗菌内肽酶 Machata, S. PDF N/A Identification of a fungal antibacterial endopeptidase that modulates immune responses
噬菌体间的竞争和生物膜降低了两种烈性噬菌体联合对抗铜绿假单胞菌的效力 Buerkle, M. PDF N/A Phage-phage competition and biofilms reduce the efficacy of a combination of two virulent bacteriophages against Pseudomonas aeruginosa
铜绿假单胞菌表面行为中PilU的作用 Zhang, J. PDF N/A The role of PilU in the surface behaviors of Pseudomonas aeruginosa
弓形虫转录因子AP2XII-8:G1期进展和寄生虫分裂的关键调控因子 Shi, Y. PDF N/A Toxoplasma gondii transcription factor AP2XII-8: a key regulator of G1 phase progression and parasite division
卷曲乳杆菌S层蛋白调节女性下生殖道先天免疫反应和炎症。 Decout, A. PDF N/A Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract.
LolA 和 LolB 在拟杆菌门中是保守的,对滑动运动和IX型分泌系统至关重要。 De Smet, T. PDF N/A LolA and LolB are conserved in Bacteroidetes and are crucial for gliding motility and Type IX secretion.
在人类原代心脏内皮细胞中,基孔肯雅病毒的差异限制发生在病毒生命周期的多个步骤。 Spector, S. N. PDF N/A Differential restriction of chikungunya virus in primary human cardiac endothelial cells occurs at multiple steps in the viral life cycle
鼻内接种表达Delta或Omicron B.1.1.529 SARS-CoV-2刺突蛋白的副流感病毒载体疫苗,可诱导黏膜和系统性免疫,并保护仓鼠免受同源和异源挑战。 Park, H.-S. PDF N/A Intranasal parainfluenza virus-vectored vaccine expressing SARS-CoV-2 spike protein of Delta or Omicron B.1.1.529 induces mucosal and systemic immunity and protects hamsters against homologous and heterologous challenge
凝聚蛋白环挤压特性、障碍物以及在酿酒酵母同源搜索中的作用 Piveteau, V. PDF N/A Condensin loop extrusion properties, roadblocks, and role in homology search in S. cerevisiae
开发一种DNA编码库筛选方法DEL Zipper,以增强对RNA靶向化学物质的研究 Ma, Z. PDF N/A Development of a DNA-encoded library screening method DEL Zipper to empower the study of RNA-targeted chemical matter
人肺基底细胞在SARS-CoV-2感染后释放的PROS1有助于上皮细胞修复并限制炎症。 Simakou, T. PDF N/A PROS1 released by human lung basal cells upon SARS-CoV-2 infection facilitates epithelial cell repair and limits inflammation.
参考样本的表观基因组、转录组和蛋白质组特征分析 Nepal, C. PDF N/A Epigenomic, transcriptomic and proteomic characterizations of reference samples
线粒体二羧酸载体在体内介导肝脏糖异生作用 Pape, D. J. PDF N/A The mitochondrial dicarboxylate carrier mediates in vivo hepatic gluconeogenesis
通过铁蛋白笼的超分子组装生成的磁性蛋白质聚集体——一种用于酶固定化的模块化策略 Olcucu, G. PDF N/A Magnetic Protein Aggregates Generated by Supramolecular Assembly of Ferritin Cages - A Modular Strategy for the Immobilization of Enzymes
使用基于肽的传感器直接测量生物膜中的PIP2密度 Menon, V. K. PDF N/A Direct measurement of PIP2 densities in biological membranes using a peptide-based sensor
目标条件扩散生成强效TNFR超家族拮抗剂和激动剂 Gloegl, M. PDF N/A Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
玻璃态表面活性剂实现超高浓度生物治疗药物 Jons, C. K. PDF N/A Glassy Surfactants Enable Ultra-High Concentration Biologic Therapeutics
清醒大鼠胃运动的磁共振成像 Wang, X. PDF N/A Magnetic Resonance Imaging of Gastric Motility in Conscious Rats
从空间转录组数据中提取生物学相关的信号 Radkevich, E. PDF N/A Informing biologically relevant signal from spatial transcriptomic data
iSeqsSearch:为iBlast/iMMSeqs2/iDiamond设计的增量蛋白质搜索工具 Yoo, H. PDF N/A iSeqsSearch: Incremental Protein Search for iBlast/iMMSeqs2/iDiamond
CodonTransformer:一种使用上下文感知神经网络的多物种密码子优化器 Fallahpour, A. PDF N/A CodonTransformer: a multispecies codon optimizer using context-aware neural networks
计算癌症治疗的斯塔克伯格均衡 Ganzfried, S. PDF N/A Computing Stackelberg Equilibrium for Cancer Treatment
探测他人的存在:跨脑尺度的概率推断揭示了增强的兴奋性突触效能 Esmaeili, A. PDF N/A Probing other's Presence: Probabilistic Inference Across Brain Scales Reveals Enhanced Excitatory Synaptic Efficacy
认知与生活方式相关的老龄化人脑海马微结构变异 Agyekum, T. PDF N/A Cognitive-and lifestyle-related microstructural variation in the ageing human hippocampus
无监督的分段线性解码能够在多任务脑机接口中准确预测肌肉活动。 Ma, X. PDF N/A Unsupervised, piecewise linear decoding enables an accurate prediction of muscle activity in a multi-task brain computer interface
眼动控制中的努力:指令和奖励在时空眼动动力学中的作用 Wolf, C. PDF N/A Effort in Oculomotor Control: Role of Instructions and Reward on Spatio-temporal Eye Movement Dynamics
一种涉及双向耦合的外侧和内侧内嗅皮层层的统一模型,用于海马体空间和物体细胞 Patil, B. K. PDF N/A A unified model of hippocampal spatial and object cells involving bidirectionally coupled Lateral and Medial Entorhinal Cortical layers
III型干扰素通过触发细胞死亡独立于STAT激活抑制甲型流感病毒感染 Prus, W. PDF N/A Type III interferons suppress influenza A virus infection independently of STAT activation by triggering cell death
计算代谢建模揭示了小鼠癌症恶病质期间肠道微生物群在代谢转变中的作用 Moissl-Eichinger, C. PDF N/A Computational metabolic modeling unveils gut microbiomes role in metabolic shifts during murine cancer cachexia
适用于快速培养乳酸杆菌(Lactobacillus iners)及其他阴道细菌的实用媒体配方 Serrador, D. PDF N/A Practical Media Formulations for Rapid Growth of Lactobacillus iners and Other Vaginal Bacteria
野生型驯化:在丰富培养基中,内在代谢特性的丧失被文化所掩盖 Vezina, B. PDF N/A Wild type domestication: loss of intrinsic metabolic traits concealed by culture in rich media
金合欢属植物(Acacia gerrardii),作为一种沙漠植物,是可持续获取具有抗菌特性的天然产品的来源。 Elkahoui, S. PDF N/A Acacia gerrardii, a desert plant as a sustainable source of natural products with antimicrobial properties
蛋白质-配体复合物中的质子化效应——以内酰胺蛋白酶和抑肽酶A为例,结合计算和实验方法进行研究 Vatheuer, H. PDF N/A Protonation effects in protein-ligand complexes - a case study of endothiapepsin and pepstatin A with computational and experimental methods
DYF-5通过影响列车转向来调节鞭毛内运输 Mul, W. PDF N/A DYF-5 regulates intraflagellar transport by affecting train turnaround
一种基于纳米抗体的方法,用于在活细胞中捕获和可视化二元蛋白质复合物的相互作用 Sleiman, N. H. PDF N/A A nanobody-based approach to capture and visualize interactions of binary protein complexes in living cells
解码酵母热休克中的转录记忆及RNA结合蛋白Mip6的功能意义 Rodriguez-Navarro, S. PDF N/A Decoding Transcriptional Memory in Yeast Heat Shock and the Functional Implication of the RNA Binding Protein Mip6
胞嘧啶-5 DNA甲基化介绍使细胞对氧化损伤敏感 Krwawicz, J. PDF N/A Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage
UM171和新生型癌症突变体的结构模拟物通过招募E3连接酶KBTBD4来共同选择HDAC1/2 Chen, Z. PDF N/A Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment
53BP1缺陷导致通过断裂诱导复制(BIR)进行超重组 Shah, S. B. PDF N/A 53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR)
计算和报告基于DIA蛋白质组学的变异系数 Brenes, A. J. PDF N/A Calculating and Reporting Coefficients of Variation for DIA-based Proteomics
2.5埃分辨率下酵母ADP-肌动蛋白丝的冷冻电镜重建。与哺乳动物和禽类F-肌动蛋白的比较。 Stevenson, S. R. PDF N/A CryoEM Reconstruction of Yeast ADP-Actin Filament at 2.5 Angstrom resolution. A comparison with mammalian and avian F-actin.
通过明胶-弹性纤维增强水凝胶进行阴道组织工程 Zambuto, S. G. PDF N/A Vaginal Tissue Engineering via Gelatin-Elastin Fiber-Reinforced Hydrogels
材料成分和植入部位影响体内设备降解速率 Pawelec, K. PDF N/A Material Composition and Implantation Site Affect in vivo Device Degradation Rate
通过考虑树突计算来克服运动传感器模型的局限性 Luna, R. PDF N/A Overcoming the limitations of motion sensor models by considering dendritic computations
一种来自天门冬科植物的新型Polerovirus,其RNA沉默抑制蛋白P0定义了该病毒的种类。 Dekker, R. J. PDF N/A A new Polerovirus species in plants from the Asparagaceae family defined by its RNA-silencing repressor protein P0