| 囊泡和非囊泡外泌体小RNA在植物相互作用细菌中指导基因沉默 |
RAVET, A. |
PDF |
N/A |
Vesicular and non-vesicular extracellular small RNAs direct gene silencing in a plant-interacting bacterium |
| 解开皮质电路中多类中间神经元的稳定性和增益调制 |
Bos, H. |
PDF |
N/A |
Untangling stability and gain modulation in cortical circuits with multiple interneuron classes |
| 自体受精脊椎动物中基因型和个体发育阶段的自体可育性变异 |
Gresham, J. D. |
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N/A |
Variation in self-compatibility among genotypes and across ontogeny in a self-fertilizing vertebrate |
| 基于细胞外基质的简单代理建模框架 |
Metzcar, J. |
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N/A |
A simple framework for agent-based modeling with extracellular matrix |
| 多组学图谱辅助发现选择性T细胞状态编程的转录因子 |
Chung, H. K. |
PDF |
N/A |
Multi-Omics Atlas-Assisted Discovery of Transcription Factors for Selective T Cell State Programming |
| IL-13促进哮喘中感觉神经与交感神经的相互作用 |
Crosson, T. |
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N/A |
IL-13 promotes sensory-sympathetic neurons crosstalk in asthma |
| 单一感觉的视觉和听觉对象在嗅觉皮层中得到处理，与气味关联无关。 |
Thunell, E. |
PDF |
N/A |
Unisensory visual and auditory objects are processed in olfactory cortex, independently of odor association |
| DGRPool：一种利用协调的果蝇遗传参考面板表型数据研究复杂性状的网络工具 |
Gardeux, V. |
PDF |
N/A |
DGRPool: A web tool leveraging harmonized Drosophila Genetic Reference Panel phenotyping data for the study of complex traits |
| 进化基因组学预测了高山森林关键树种对气候变化的适应性遗传和可塑性基因表达反应 |
Long, Z. |
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N/A |
Evolutionary genomics predicts adaptive genetic and plastic gene expression responses to climate change in a key alpine forest tree species |
| 未来的抗生素在革兰氏阴性病原体中容易产生抗药性。 |
Daruka, L. |
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N/A |
Antibiotics of the future are prone to resistance in Gram-negative pathogens |
| 主要人类诺如病毒的依赖RNA的RNA聚合酶会形成液-液相分离凝聚体，作为病毒复制工厂。 |
Kaundal, S. |
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N/A |
RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories |
| 膜脂质纳米域调节伤害感受器背根神经节神经元中的HCN起搏通道 |
Handlin, L. J. |
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N/A |
Membrane Lipid Nanodomains Modulate HCN Pacemaker Channels in Nociceptor DRG Neurons |
| 行为上无关的特征匹配增加了神经和行为工作记忆的读出 |
Karabay, A. |
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N/A |
Behaviorally irrelevant feature matching increases neural and behavioral working memory readout |
| HybriSeq：基于探针的无设备单细胞RNA分析 |
Foyt, D. |
PDF |
N/A |
HybriSeq: Probe-based Device-free Single-cell RNA Profiling |
| 蜱虫的胞外囊泡在吸血过程中破坏表皮伤口愈合 |
Marnin, L. |
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N/A |
Tick extracellular vesicles undermine epidermal wound healing during hematophagy |
| 三种RING蛋白的不同且相互依赖的功能调控哺乳动物减数分裂中的重组 |
Ito, M. |
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N/A |
Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis |
| 人类RAD52的双环结构重塑复制叉，限制叉反转 |
Honda, M. |
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N/A |
A double-ring of human RAD52 remodels replication forks restricting fork reversal |
| 图神经网络在人类大脑网络中结构-功能耦合的群体共性和个体特异性效应 |
Chen, P. |
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N/A |
Group-common and individual-specific effects of structure-function coupling in human brain networks with graph neural networks |
| 骨骼肌卫星细胞利用肌腱生成基因Scleraxis指导再生 |
Bai, Y. |
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N/A |
Skeletal Muscle Satellite Cells Co-Opt the Tenogenic Gene Scleraxis to Instruct Regeneration |
| 使用HaloTag技术在hiPSC衍生的单细胞和类器官中可视化PIEZO1的定位和活性 |
Bertaccini, G. A. |
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N/A |
Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology |
| 计算加速的P-糖蛋白抑制剂识别 |
McCormick, L. A. |
PDF |
N/A |
Computationally accelerated identification of P-glycoprotein inhibitors |
| 利用生物电化学电池从甜菜汁中发电 |
Shlosberg, Y. |
PDF |
N/A |
Photoelectricity generation from beet juice in a bio-electrochemical cell |
| 基于假设的可解释神经网络用于基因间相互作用 |
Wang, S. |
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N/A |
Hypothesis-driven interpretable neural network for interactions between genes |
| 蛋白质-配体结合亲和力预测：是否需要三维结合构象？ |
Wu, M.-H. |
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N/A |
Protein-ligand binding affinity prediction: Is 3D binding pose needed? |
| 内质网接触点促进含沙门氏菌液泡（SCV）的协调分裂 |
Chopra, U. |
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N/A |
Endoplasmic Reticulum contact sites facilitate the coordinated division of Salmonella-containing vacuole (SCV) |
| 肿瘤微环境噪声诱导的极化：巨噬细胞癌症免疫治疗的主要挑战。 |
Sierra, J. |
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N/A |
Tumor microenvironment noise-induced polarization: the main challenge in macrophages' immunotherapy for cancer. |
| 蛋白质组学和脂质组学血浆评估揭示加州海狮的软骨藻酸中毒生物标志物 |
Solosky, A. M. |
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N/A |
Proteomic and Lipidomic Plasma Evaluations Reveal Biomarkers for Domoic Acid Toxicosis in California Sea Lions |
| 分子媒人：植原体效应因子SAP54通过靶向MADS-box因子SVP，通过调节叶片对雄性存在的反应，增强了对多产雌性媒介的吸引力 |
Orlovskis, Z. |
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N/A |
Molecular Matchmakers: Phytoplasma Effector SAP54 Targets MADS-Box Factor SVP to Enhance Attraction of Fecund Female Vectors by Modulating Leaf Responses to Male Presence |
| 使用Sentence-BERT从预测数据库中提炼疾病相关的蛋白质水平微RNA靶标相互作用 |
Chen, B. |
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N/A |
Refining Protein-Level MicroRNA Target Interactions in Disease from Prediction Databases Using Sentence-BERT |
| 利用无人机系统和计算机视觉对涉禽进行近实时监测 |
White, E. P. |
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N/A |
Near real-time monitoring of wading birds using uncrewed aircraft systems and computer vision |
| 探索选择的多元信心 |
Solopchuk, O. |
PDF |
N/A |
Multifaceted confidence in exploratory choice |
| 恐惧记忆合作与竞争的时间规则 |
Madeira, N. |
PDF |
N/A |
Temporal rules of fear memory cooperation and competition |
| 同型相分离的直接和间接盐效应 |
MacAinsh, M. |
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N/A |
Direct and Indirect Salt Effects on Homotypic Phase Separation |
| 基于模型的浮萍生物发光报告基因活动昼夜节律生成分析 |
Horikawa, Y. |
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N/A |
Model-based analysis of the circadian rhythm generation of bioluminescence reporter activity in duckweed |
| 按蚊种群空间结构在冈比亚按蚊复合体中的变异 |
McCann, R. S. |
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N/A |
Variation in spatial population structure in the Anopheles gambiae species complex |
| 一年内皮层厚度、表面积和脑体积的个体内部稳定性 |
Wang, M.-Y. |
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N/A |
The within-subject stability of cortical thickness, surface area, and brain volumes across one year |
| 在许多研究中，可避免的假PSMC种群规模峰值时有发生。 |
Hilgers, L. |
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N/A |
Avoidable false PSMC population size peaks occur across numerous studies |
| 基因型与环境相互作用在基因调控中的作用，揭示了模式草本植物短柄草（Brachypodium distachyon）对土壤干燥的响应机制。 |
Yun, J. |
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N/A |
Genotype by environment interactions in gene regulation underlie the response to soil drying in the model grass Brachypodium distachyon |
| 突变扩展规律揭示，通过基因扩增实现加速进化需要空间结构化的种群增长。 |
Komarova, N. |
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N/A |
Mutant scaling laws reveal that accelerated evolution via gene amplification requires spatially structured population growth |
| 免疫检查点抑制后的细胞动力学 |
Lin, Z. |
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N/A |
Cellular Dynamics Upon Immune Checkpoint Inhibition |
| 从单一序列到进化轨迹：蛋白质语言模型捕捉SARS-CoV-2蛋白质序列的进化潜力 |
Lamb, K. D. |
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N/A |
From a single sequence to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2 protein sequences |
| ANASFV：一种用于非洲猪瘟病毒全基因组测序、组装和评估的工作流程 |
Li, K. |
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N/A |
ANASFV: a workflow for ASFV whole genome sequencing, assembly, and evaluation |
| bam转录本的失稳终止了果蝇雌性生殖系分化的有丝分裂阶段 |
Samuels, T. J. |
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N/A |
Destabilisation of bam transcripts terminates the mitotic phase of Drosophila female germline differentiation |
| 使用全原子模拟对错误建模的冷冻电镜RNA结构进行集合细化 |
Posani, E. |
PDF |
N/A |
Ensemble Refinement of mismodeled cryo-EM RNA Structures Using All-Atom Simulations |
| 撤回：木薯褐条病致病病毒间的种间重组 |
Astacio-Berrios, K. |
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N/A |
WITHDRAWN: Interspecies recombination between cassava brown streak disease-causing viruses |
| 蓝藻中m4C DNA甲基化对四吡咯生物合成的表观遗传调控 |
Schmidt, N. |
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N/A |
Epigenetic control of tetrapyrrole biosynthesis by m4C DNA methylation in a cyanobacterium |
| 分离的基底神经节输出通路与基因上不同的神经元亚类相对应。 |
Mendelsohn, A. |
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N/A |
Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses |
| 安第斯叶耳鼠（Phyllotis）的物种界限与杂交现象 |
Quiroga-Carmona, M. |
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N/A |
Species limits and hybridization in Andean leaf-eared mice (Phyllotis) |
| 泛基因组学用于理解Pectobacterium属中的原噬菌体动力学以及P. brasiliense辐射谱系的演化 |
Pardeshi, L. A. |
PDF |
N/A |
Pangenomics to understand prophage dynamics in the Pectobacterium genus and the radiating lineages of P. brasiliense |
| 丝虫精子发生过程中重组、X染色体失活及着丝粒蛋白的动态变化 |
Toubiana, W. |
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N/A |
Dynamics of recombination, X inactivation and centromere proteins during stick insect spermatogenesis |
| 梅克尔细胞癌衍生的巨噬细胞移动抑制因子（MIF）可能促进慢性淋巴细胞白血病的持续存在。 |
Alencar, G. F. |
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N/A |
Merkel cell carcinoma-derived macrophage migration inhibitory factor (MIF) may promote persistence of Chronic Lymphocytic Leukemia |
| 在海马体的循环网络模型中，条形码活动能够实现高效的记忆绑定。 |
Fang, C. |
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N/A |
Barcode activity in a recurrent network model of the hippocampus enables efficient memory binding |
| Mouse-Geneformer：一种用于小鼠单细胞转录组的深度学习模型及其跨物种应用 |
Ito, K. |
PDF |
N/A |
Mouse-Geneformer: A Deep Learning Model for Mouse Single-Cell Transcriptome and Its Cross-Species Utility |
| 物体非刚性的各向异性：皮层各向异性的高层次感知结果 |
Maruya, A. |
PDF |
N/A |
Anisotropy of object non-rigidity: High-level perceptual consequences of cortical anisotropy |
| LncRNA TAAL是糖尿病视网膜病变中通过Tie1介导的血管功能的调节因子 |
Ranjan, G. |
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N/A |
LncRNA TAAL is a Modulator of Tie1-Mediated Vascular Function in Diabetic Retinopathy |
| MEK1/2激酶与c-Myc:MAX协同作用，防止人类多能干细胞中TERT受到多梳蛋白的抑制。 |
Kotian, S. T. |
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N/A |
MEK1/2 kinases cooperate with c-Myc:MAX to prevent polycomb repression of TERT in human pluripotent stem cells |
| MAPK/ERK信号通路在胶质瘤中调控干扰素反应、T细胞招募，增强肿瘤-小胶质细胞间的相互作用，并推动免疫检查点阻断疗法的疗效。 |
Kim, K.-S. |
PDF |
N/A |
MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy. |
| MAPK/ERK信号通路在胶质瘤中调节干扰素反应、T细胞招募，增强肿瘤与小胶质细胞的相互作用，并推动免疫检查点阻断疗法的疗效。 |
Kim, K.-S. |
PDF |
N/A |
MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy. |
| 蜱虫中单一的 ANP32 祖先位点创造了多种蛋白质变体，这些变体均支持 Thogoto 病毒聚合酶的功能。 |
Zhang, Z. |
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N/A |
A single ancestral ANP32 locus in ticks creates multiple protein variants that all support the Thogoto virus polymerase |
| 海马体中人口活动的稀疏性在三突触回路和背腹轴上是任务不变的。 |
Lee, J. Q. |
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N/A |
Sparsity of population activity in the hippocampus is task-invariant across the trisynaptic circuit and dorsoventral axis |
| 从前馈到反馈节奏的表征转变，在自然视觉中标志着现象学整合的指标。 |
Chen, L. |
PDF |
N/A |
Representational shifts from feedforward to feedback rhythms index phenomenological integration in naturalistic vision |
| 面部表情与颜色在调节ERP P3中的相互作用 |
Hasegawa, Y. |
PDF |
N/A |
Interaction between facial expression and color in modulating ERP P3 |
| 一个涵盖5000年历史的考古牙结石数据集，用于古代人类口腔微生物组研究 |
Standeven, F. J. |
PDF |
N/A |
An extensive archaeological dental calculus dataset spanning 5000 years for ancient human oral microbiome research |
| 一种慢性小鼠肺部鲍曼不动杆菌感染模型，可用于研究晚期毒力因子、长期抗生素治疗和多微生物感染。 |
Jackson-Litteken, C. D. |
PDF |
N/A |
A chronic murine model of pulmonary Acinetobacter baumannii infection enabling the investigation of late virulence factors, long-term antibiotic treatments, and polymicrobial infections |
| 无细胞人乳头瘤病毒DNA在转移性或复发性宫颈癌中的监测：临床意义与治疗启示 |
Yin, Z. |
PDF |
N/A |
Monitoring of Cell-free Human Papillomavirus DNA in Metastatic or Recurrent Cervical Cancer: Clinical Significance and Treatment Implications |
| 肢体上的学习：一个旨在吸引高中生参与骨科的推广模块 |
Panebianco, C. J. |
PDF |
N/A |
Learning on a Limb: An outreach module to engage high school students in orthopaedics |
| 药物难治性癫痫中的性别特异性补体和细胞因子失衡：免疫脆弱性的生物标志物 |
Pinzon-Hoyos, N. |
PDF |
N/A |
Sex-Specific Complement and Cytokine Imbalances in Drug-Resistant Epilepsy: Biomarkers of Immune Vulnerability |
| 非平衡涨落-耗散定理为阿尔茨海默病研究铺平道路 |
Patow, G. A. |
PDF |
N/A |
Off-Equilibrium Fluctuation-Dissipation Theorem Paves the Way in Alzheimer's Disease Research |
| 阿尔茨海默病中默认模式网络功能障碍和认知衰退的神经生理学特征。 |
Ozdemir, R. A. |
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N/A |
Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer disease. |
| 相机类型、高度及图像增强对浑浊海洋环境中摄影测量成功率的影响。 |
Savill, K. L. |
PDF |
N/A |
Influence of camera type, height and image enhancement on photogrammetry success in turbid marine environments. |
| 系统性CD8+ T细胞效应器特征预测肺癌免疫治疗预后 |
Sim, H. |
PDF |
N/A |
Systemic CD8+ T cell effector signature predicts prognosis of lung cancer immunotherapy |
| 支气管和鼻腔粘液的比较表征揭示了流感A病毒抑制的关键决定因素 |
Pohl, M. O. |
PDF |
N/A |
Comparative Characterization of Bronchial and Nasal Mucus Reveals Key Determinants of Influenza A Virus Inhibition |
| Medin诱导人脑血管平滑肌细胞的促炎激活 |
Karamanova, N. |
PDF |
N/A |
Medin Induces Pro-Inflammatory Activation of Human Brain Vascular Smooth Muscle Cells |
| CRISPR/Cas9诱导的断裂不足以打破番茄（Solanum lycopersicum）中烟草花叶病毒（ToMV）位点周围的连锁拖曳。 |
Grubben, J. |
PDF |
N/A |
CRISPR/Cas9-induced breaks are insufficient to break linkage drag surrounding the ToMV locus of Solanum lycopersicum |
| 豆科（Legume）安麦斯米亚族（Amherstieae）中的生态位保守性：来自热带柏林尼亚支系（Berlinia）和布劳恩尼亚支系（Brownea）的启示 |
Romero, I. C. |
PDF |
N/A |
Niche conservatism in the Legume Amherstieae tribe: Insights from the tropical Berlinia and Brownea clades |
| 非重组种群中选择性清除过程中的遗传多样性 |
Kaushik, S. |
PDF |
N/A |
Genetic diversity during selective sweeps in non-recombining populations |
| 一种用于治疗性RNA质量控制的纳米孔测序碱基识别的迭代优化方法 |
Wang, Z. |
PDF |
N/A |
An Iterative Approach to Polish the Nanopore Sequencing Basecalling for Therapeutic RNA Quality Control |
| 按蚊中分子Toll通路的多样性 |
Rhodes, V. L. |
PDF |
N/A |
The molecular Toll pathway repertoire in anopheline mosquitoes |
| 一种红色荧光Lifeact标记物用于研究足细胞中的肌动蛋白形态 |
Wiesner, E. |
PDF |
N/A |
A Red Fluorescent Lifeact Marker to Study Actin Morphology in Podocytes |
| 选择常染色体显性DFNA11耳聋突变激活上皮细胞中的Myo7A |
Acharya, P. |
PDF |
N/A |
Select autosomal dominant DFNA11 deafness mutations activate Myo7A in epithelial cells |
| 靶向与帕金森病相关的LRRK2的II型激酶抑制剂 |
Raig, N. D. |
PDF |
N/A |
Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2 |
| Seipin调控了Caveolin-1的运输以及细胞器间的交流 |
Carpentier, M. |
PDF |
N/A |
Seipin Regulates Caveolin-1 Trafficking and Organelle Crosstalk |
| 甲醛在用于哺乳动物细胞培养时对信号通路的影响 |
Ostmann, K. |
PDF |
N/A |
Influence of formaldehyde on signaling pathways when used in mammalian cell culture |
| A型和B型核纤层蛋白的详细共定位分析：使用超分辨率STED显微镜和去卷积的工作流程 |
Stiekema, M. |
PDF |
N/A |
Detailed Colocalization Analysis of A- and B-type Nuclear Lamins: a Workflow Using Super-Resolution STED Microscopy and Deconvolution |
| 溶酶体膜蛋白LAMP2B介导微脂质吞噬作用，以针对与肥胖相关疾病 |
Sakai, R. |
PDF |
N/A |
The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders |
| 通过等离子体超表面实现活细胞的中红外化学成像 |
Huang, S. H. |
PDF |
N/A |
Mid-infrared chemical imaging of living cells enabled by plasmonic metasurfaces |
| 降低氧化应激改善了基于聚合物的体外人类造血干细胞和祖细胞培养及基因编辑 |
Bozhilov, Y. |
PDF |
N/A |
Reducing oxidative stress improves ex vivo polymer-based human haematopoietic stem and progenitor cell culture and gene editing |
| 后负荷诱导的脂肪酸氧化减少独立于葡萄糖利用增加而发展 |
Piristine, H. |
PDF |
N/A |
Afterload-induced Decreases in Fatty Acid Oxidation Develop Independently of Increased Glucose Utilization |
| 解锁精准：角膜细胞面积分析如何革新移植后干细胞监测 |
Parkinson, P. |
PDF |
N/A |
Unlocking precision: How corneal cell area analysis revolutionises post-transplant stem cell monitoring |
| 体外评估挪威云杉（Picea abies）树脂提取物在口腔护理应用中的抗炎、抗牙菌斑功效及生物相容性 |
Yamileva, K. |
PDF |
N/A |
In Vitro Evaluation of Anti-Inflammatory, Anti-Plaque Efficacy, and Biocompatibility of Norway Spruce (Picea abies) Resin Extract for Oral Care Applications |
| 社会注意力取决于精确度的调节 |
Gao, W. |
PDF |
N/A |
Precision-dependent modulation of social attention |
| 采用SynthSeg框架和规范建模方法进行多发性硬化萎缩的纵向表征 |
Gordaliza, P. M. |
PDF |
N/A |
Towards Longitudinal Characterization of Multiple Sclerosis Atrophy Employing SynthSeg Framework and Normative Modeling |
| CRISPR筛选用于rAAV生产的基因，揭示了与感染相关的基因 |
O'Driscoll, E. |
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CRISPR screen for rAAV production implicates genes associated with infection |
| 每月对大型藻类的调查揭示了城市潮间带中一个多样且动态的生物群落。 |
Schenk, S. |
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N/A |
Monthly macroalgal surveys reveal a diverse and dynamic community in an urban intertidal zone |
| 针对未被关注的目标：揭示根系分泌物的化学复杂性 |
Moeller, K. |
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N/A |
Targeting the untargeted: Uncovering the chemical complexity of root exudates |
| 在孟德尔群体中，利他主义全同胞之间的生存成本分担 |
Garay, J. |
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Survival cost sharing among altruistic full siblings in Mendelian population |
| 在大规模临床肺癌样本中筛选和鉴定基因表达，揭示了EZH2和SOX2的主要作用。 |
Niharika, |
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N/A |
Screening and identification of gene expression in large cohorts of clinical lung cancer samples unveils the major involvement of EZH2 and SOX2 |
| 结核菌细胞壁阿拉伯聚糖末端阿拉伯糖基化的结构洞察 |
Liu, Y. |
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N/A |
Structural insights into terminal arabinosylation biosynthesis of the mycobacterial cell wall arabinan |
| 通过甘露糖基转移酶PimE研究分枝杆菌糖脂生物合成的机制 |
Liu, Y. |
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N/A |
Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE |
| 一种针对大蜡螟蛾（Galleria mellonella）的显微注射技术方案 |
Pearce, J. C. |
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A microinjection protocol for the greater waxworm moth, Galleria mellonella |
| 可溶性细胞间通讯的工程受体 |
Piraner, D. I. |
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N/A |
Engineered Receptors for Soluble Cell-to-Cell Communication |
| 不同硬度聚丙烯酰胺（PAAm）水凝胶的合成及其在大批量细胞培养应用中的力学表征 |
Cresens, C. |
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N/A |
Synthesis and mechanical characterization of polyacrylamide (PAAm) hydrogels with different stiffnesses for large-batch cell culture applications |
| UDG识别出双链DNA中翻转出来的尿嘧啶碱基的“那一刻” |
Saravanan, V. |
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The "very moment" when UDG recognizes aflipped-out uracil base in dsDNA |
| 基于网络的抗癌药物组合疗效和不良反应潜力评估，以优先排序 |
Ghosh, A. |
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Network-based estimation of therapeutic efficacy and adverse reaction potential for prioritisation of anti-cancer drug combinations |
| 一种综合方法，用于提取经历液-液相分离的球状蛋白质的旋转动力学 |
Gendreizig, D. |
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N/A |
A combined approach to extract rotational dynamics of globular proteins undergoing liquid-liquid phase separation |
| 综合多组学方法揭示ZMAT3和p21在p53肿瘤抑制网络中作为保守枢纽的作用 |
Boutelle, A. M. |
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Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network |
| 鉴定针对FGFR2融合驱动的胆管癌的高效双特异性抗体。 |
Chaturantabut, S. |
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Identification of potent biparatopic antibodies targeting FGFR2 fusion driven cholangiocarcinoma. |
| 通过单细胞空间分析鉴定人肺组织中结核菌感染的SPP1阳性巨噬细胞 |
Katano, H. |
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Identification of SPP1-positive macrophages by single-cell spatial analysis in human lung tissues with mycobacterial infection |
| 内皮miR-34a缺失虽导致内皮功能障碍，但能防止动脉瘤的发展。 |
Grochot-Przeczek, A. |
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N/A |
Endothelial miR-34a deletion guards against aneurysm development despite endothelial dysfunction |
| 胆固醇与VCAM-1结合促进血管炎症 |
Kennelly, J. P. |
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Cholesterol binding to VCAM-1 promotes vascular inflammation |
| 灵长类主要组织相容性复合体：基因家族进化的一个典型例证 |
Fortier, A. L. |
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The Primate Major Histocompatibility Complex: An Illustrative Example of Gene Family Evolution |
| 果蝇母体效应基因异常卵细胞（ao）并不抑制组蛋白基因的表达。 |
Takenaka, R. |
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The Drosophila maternal-effect gene abnormal oocyte (ao) does not repress histone gene expression |
| 一个驱动不可简化的分子复合物反复进化的调控模块。 |
Tikanova, P. |
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A regulatory module driving the recurrent evolution of irreducible molecular complexes. |
| 犬基因组组装中核线粒体插入的特征分析 |
Schall, P. Z. |
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Characterization of nuclear mitochondrial insertions in canine genome assemblies |
| 从单体到寡聚体：先天免疫信号传导中受体触发的MyD88组装的结构机制 |
Kasai, K. |
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From Monomers to Oligomers: Structural Mechanism of Receptor-Triggered MyD88 Assembly in Innate Immune Signaling |
| 突变型p53错误折叠与聚集先于高级别浆液性卵巢癌的转化 |
Sartini, S. |
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Mutant p53 Misfolding and Aggregation Precedes Transformation into High-Grade Serous Ovarian Carcinoma |
| 体外小鼠精准切割肿瘤切片用于肝细胞癌建模；一种适用于大规模药物筛选的3R解决方案 |
Collins, A. L. |
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Ex-vivo mouse precision cut tumour slices for modelling hepatocellular carcinoma; A 3Rs solution for at-scale drug screening |
| 体外和体内评估海藻对伤口愈合的作用 |
Wang, C.-H. |
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In vitro and in vivo evaluation of Ulva lactuca for wound healing |
| 在杂交小麦种子生产中，污点持久性并不是一个主要的限制因素。 |
Millan-Blanquez, M. |
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Stigma longevity is not a major limiting factor in hybrid wheat seed production |
| 评估HIV-1包膜构象可塑性背景下的广谱中和抗体效能 |
Foulkes, C. |
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Assessing bnAb potency in the context of HIV-1 Envelope conformational plasticity |
| 研究法洛四联症右心室血流动力学：一项计算研究 |
Renzi, F. |
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N/A |
Investigating the right heart hemodynamics in the Tetralogy of Fallot: a computational study |
| PANOMIQ：一种统一的全基因组、外显子和微生物组数据分析方法 |
Srivastava, S. |
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PANOMIQ: A Unified Approach to Whole-Genome, Exome, and Microbiome Data Analysis |
| RCoxNet：结合随机游走重启与突变及临床数据的癌症生存预测深度学习框架 |
Kumari, S. |
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N/A |
RCoxNet: deep learning framework for enhanced cancer survival prediction integrating random walk with restart with mutation and clinical data |
| 协同药物发现中的主动学习指南 |
Wang, S. |
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A Guide for Active Learning in Synergistic Drug Discovery |
| FunCoup 6：通过引入有向链接和提升用户体验，推进跨物种功能关联网络的发展 |
Buzzao, D. |
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FunCoup 6: advancing functional association networks across species with directed links and improved user experience |
| 环境和未减数配子的遗传结构如何影响同源多倍体的形成 |
Cheng, Y. |
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How environment and genetic architecture of unreduced gametes shape the establishment of autopolyploids |
| 动物遗传变异致病性客观评估的变异分类指南 |
Boeykens, F. |
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Variant classification guidelines for animals to objectively evaluate genetic variant pathogenicity |
| 侧前额叶皮层控制工作记忆与行动之间的相互作用。 |
Kiyonaga, A. |
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Lateral prefrontal cortex controls interplay between working memory and actions |
| 急性病毒感染加速肌萎缩侧索硬化症小鼠模型中的神经退行性变 |
Marzok, A. |
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Acute Viral Infection Accelerates Neurodegeneration in a Mouse Model of ALS |
| 蛋白质组学和N-糖基组学比较：合成与牛乳清蛋白及其对人类肠道微生物群的影响 |
Bolino, M. |
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N/A |
Proteomic and N-glycomic comparison of synthetic and bovine whey proteins and their effect on human gut microbiomes |
| 分子活性调节湖泊沉积物中溶解有机质的组成和组装 |
Wen, S. |
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N/A |
Molecular activity mediates the composition and assembly of dissolved organic matter in lake sediments |
| 胞质CRISPR RNA用于RNA靶向CRISPR-Cas系统 |
Kwon, S. C. |
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Cytosolic CRISPR RNA for RNA-targeting CRISPR-Cas systems |
| 基于转录程序的MET外显子14跳跃调控网络解析 |
Truong, M.-J. |
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Transcriptional-program-based deciphering of the MET exon 14 skipping regulation network |
| Cas9AEY（Cas9辅助的非特异性大肠杆菌酵母载体同源重组组装）构建大型DNA的方法。 |
ma, x. |
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N/A |
Cas9AEY (Cas9-facilitated Homologous Recombination Assembly of non-specific Escherichia coli yeast vector) method of constructing large-sized DNA. |
| 肠道定居调节性T细胞（GTregs）的稳态平衡在维持绝经后骨质疏松症条件下的骨骼健康中起着关键作用。 |
Bhardwaj, A. |
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N/A |
Homeostatic balance of Gut-resident Tregs (GTregs) plays a pivotal role in maintaining bone health under post-menopausal osteoporotic conditions |
| IL-27中和以调节肿瘤微环境并提高免疫检查点免疫治疗效果 |
Papargyris, L. |
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N/A |
IL-27 neutralization to modulate the tumor microenvironment and increase immune checkpoint immunotherapy efficacy |
| NMI通过激活NF-kappaB通路诱导趋化因子释放并招募中性粒细胞。 |
Chen, Z. |
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NMI induces chemokine release and recruits neutrophils through the activation of NF-kappaB pathway |
| 疟原虫物种的DNA复制动力学与基因组组成相关 |
Totanes, F. I. G. |
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N/A |
DNA replication dynamics are associated with genome composition in Plasmodium species |
| 一种从古代口腔微生物组创建宏基因组组装基因组的高效流程 |
Standeven, F. J. |
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N/A |
An efficient pipeline for creating metagenomic-assembled genomes from ancient oral microbiomes |
| 一种针对泛素调节的功能性筛选鉴定出由铜绿假单胞菌分泌的E3连接酶 |
Roberts, C. G. |
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A functional screen for ubiquitin regulation identifies an E3 ligase secreted by Pseudomonas aeruginosa |
| 系统基因组引导下发现古菌与细菌之间的拮抗相互作用 |
Strock, R. |
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N/A |
Systematic genome-guided discovery of antagonistic interactions between archaea and bacteria |
| APEX2 细菌中RNA的邻近标记 |
Yassine, H. |
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APEX2 proximity labeling of RNA in bacteria |
| 位于VIM-2活性位点附近的保守辅助残基影响其金属β-内酰胺酶活性。 |
Jain, D. |
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Conserved ancillary residues situated proximally to the VIM-2 active site affect its metallo β-lactamase activity |
| 接种物大小对阿维巴坦-阿奇霉素组合在小鼠腹膜炎模型中体内活性的影响，该模型由表达CTX-M-15和NDM-1的大肠杆菌引起 |
Benchetrit, L. |
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N/A |
Impact of the inoculum size on the in vivo activity of the aztreonam-avibactam combination in a murine model of peritonitis due to Escherichia coli expressing CTX-M-15 and NDM-1 |
| 微囊藻毒素通过社群过滤和影响交叉喂养互动来塑造微囊藻的藻圈。 |
Grosse, R. |
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N/A |
Microcystin shapes the Microcystis phycosphere through community filtering and by influencing cross-feeding interactions |
| 帽非依赖性翻译指导原生动物寄生虫刚地弓形虫应激诱导的分化 |
Dey, V. |
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N/A |
Cap-independent translation directs stress-induced differentiation of the protozoan parasite Toxoplasma gondii |
| 痤疮丙酸杆菌适应人类生活的特性提供了一种新的痤疮丙酸杆菌感染的生物标志物。 |
Shafiuddin, M. |
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N/A |
Cutibacterium adaptation to life on humans provides a novel biomarker of C. acnes infections. |
| U2AF调控核编码线粒体mRNA的翻译和定位 |
Garcia, G. R. |
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U2AF regulates the translation and localization of nuclear-encoded mitochondrial mRNAs |
| 核心剪接结构和早期剪接体识别决定了微外显子对SRRM3/4的敏感性 |
Bonnal, S. |
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N/A |
Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4 |
| 利用面部侧面相似性改进人工智能驱动的海龟照片识别系统 |
Adam, L. |
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N/A |
Exploiting facial side similarities to improve AI-driven sea turtle photo-identification systems |
| 利用PiggyBac介导的转基因技术与CRISPR/Cas9敲除技术在大蜡螟（Galleria mellonella）中的应用 |
Pearce, J. C. |
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N/A |
PiggyBac mediated transgenesis and CRISPR/Cas9 knockout in the greater waxmoth, Galleria mellonella |
| 细胞衍生基质力学作为胶原蛋白VI相关先天性肌营养不良症的功能性读数 |
White, T. |
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N/A |
Cell-derived matrices mechanics as a functional read-out in Collagen VI-related Congenital Muscular Dystrophies |
| 喹啉协同作用与用量减少：一项药效动力学相互作用研究 |
Sadouki, Z. |
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N/A |
Quinoline synergy and reduced use: a study of pharmacodynamic interactions |
| 利用活体叶片切片成像技术分析C4植物叶肉细胞中依赖于维管束鞘细胞的叶绿体运动 |
Kato, Y. |
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N/A |
Bundle sheath cell-dependent chloroplast movement in mesophyll cells of C4 plants analyzed using live leaf-section imaging |
| DNA模板空间控制蛋白水解靶向嵌合体用于CyclinD1-CDK4/6复合物蛋白降解 |
Zheng, R. |
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N/A |
DNA-templated spatially controlled proteolysis targeting chimeras for CyclinD1-CDK4/6 complex protein degradation |
| 来自结核分枝杆菌临床分离株的MHC I类/II类限制性T细胞表位：结核病疫苗开发的潜在候选者 |
Sharma, N. |
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N/A |
MHC class I / II restricted T cell epitopes from clinical isolate of Mycobacterium tuberculosis: A potential candidate for vaccine development for Tuberculosis |
| 光合作用由含有天线的视紫红质在浮游的Asgard古菌中进行 |
Tzlil, G. |
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N/A |
Light-harvesting by antenna-containing rhodopsins in pelagic Asgard archaea |
| 人巨细胞病毒vGPCR UL33对于上皮细胞中高效裂解复制至关重要 |
Freeman, M. R. |
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The Human Cytomegalovirus vGPCR UL33 is Essential for Efficient Lytic Replication in Epithelial Cells |
| 通过多元素和锶同位素比率增强木材溯源性：来自东阿尔卑斯山的一个例子 |
Aguzzoni, A. |
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N/A |
Enhancing timber traceability via multielement and strontium isotope ratio: An example from the Eastern Alps |
| metagWGS是一种综合工作流程，利用Illumina或PacBio HiFi读取数据来分析宏基因组数据。 |
Mainguy, J. |
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N/A |
metagWGS, a comprehensive workflow to analyze metagenomic data using Illumina or PacBio HiFi reads |
| YTHDF1通过促进EEF1G翻译，以m6A依赖的方式促进肺腺癌进展 |
Wang, L. |
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YTHDF1 Facilitates Lung Adenocarcinoma Progression via Promotion of EEF1G Translation in a m6A-Dependent Manner |