| 一种由光触发的非经典平面细胞极性通路 |
Housset, M. |
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N/A |
A non-canonical planar cell polarity pathway triggered by light |
| 一种宿主内感染模型，用于探究耐受性和抗性 |
Duneau, D. |
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N/A |
A within-host infection model to explore tolerance andresistance |
| 一种探究宿主体内耐受性和抵抗力的感染模型 |
Duneau, D. |
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N/A |
A within-host infection model to explore tolerance andresistance |
| 在恶性疟原虫感染的红细胞中，一个不寻常的MSRP6转运域定义了一个复杂结构，该结构对于Maurer裂隙的锚定和维持是必需的。 |
Blancke Soares, A. |
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N/A |
An unusual trafficking domain in MSRP6 defines a complex needed for Maurer's clefts anchoring and maintenance in P. falciparum infected red blood cells |
| iTRVZ：用于整合细胞膜信号的纳米液态平台 |
Tsunoyama, T. A. |
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N/A |
iTRVZ: liquid nano-platform for signal integration on the plasma membrane |
| 通过人类心室电机械建模和模拟解释急性与慢性梗塞的临床表型 |
Zhou, X. |
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N/A |
Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations |
| 新型猪模型揭示肺发育和稳态过程中存在两种不同的LGR5细胞类型 |
Polkoff, K. |
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N/A |
Novel porcine model reveals two distinct LGR5 cell types during lung development and homeostasis |
| 使用深度学习预测代谢物对饮食干预的反应 |
Wang, T. |
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N/A |
Predicting metabolite response to dietary intervention using deep learning |
| 全基因组DNA修复蛋白的分析揭示了单细胞中更高层次的协调 |
de Luca, K. L. |
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N/A |
Genome-wide profiling of DNA repair proteins identifies higher-order coordination in single cells |
| 视觉皮层中多个移动刺激的神经表征中双眼视差和注意力的作用 |
Chakrala, A. S. |
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N/A |
The role of binocular disparity and attention in the neural representation of multiple moving stimuli in the visual cortex |
| 联想学习和非联想学习对防御行为动态的贡献 |
Le, Q.-S. E. |
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N/A |
Contributions of associative and non-associative learning to the dynamics of defensive ethograms |
| 在巨型基因组植物黑种草（Nigella damascena L.）的异染色质复制过程中，全球核重组。 |
Arifulin, E. |
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N/A |
Global nuclear reorganization during heterochromatin replication in the giant-genome plant Nigella damascena L. |
| 电影揭示了婴儿视觉皮层的精细结构 |
Ellis, C. T. |
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N/A |
Movies reveal the fine-grained organization of infant visual cortex |
| 认知努力增加了奖励的强度。 |
Wahab, M. |
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N/A |
Cognitive effort increases the intensity of rewards |
| 胎儿和成人胸腺中T细胞受体（TCR）基因片段的使用和MHC限制性存在明显差异。 |
Rowell, J. |
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N/A |
Distinct T Cell Receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus |
| 一种从延迟的消化后反馈中学习的神经机制 |
Zimmerman, C. A. |
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N/A |
A neural mechanism for learning from delayed postingestive feedback |
| 鳞头松鸡和北鹑的关键繁殖行为受温度变化和平均温度的影响。 |
Kirkpatrick, W. |
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N/A |
Critical reproductive behaviors in Scaled Quail and Northern Bobwhite are affected by thermal variability and mean temperature |
| p53通过关联基因组完整性和衰老相关炎症的相互调控 |
Miller, K. N. |
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N/A |
Linked regulation of genome integrity and senescence-associated inflammation by p53 |
| 基于微生物组的随机误差校正方法，用于从自我报告的饮食评估中得出的营养素谱 |
Wang, T. |
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N/A |
Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments |
| 人类理性地适应对不确定性的近似估计。 |
Pulcu, E. |
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N/A |
Humans adapt rationally to approximate estimates of uncertainty |
| 基准测试单个降解蛋白质的鉴定，以探索古代蛋白质的最佳搜索策略 |
Rodriguez Palomo, I. |
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N/A |
Benchmarking the identification of a single degraded protein to explore optimal search strategies for ancient proteins |
| 利用AlphaFold进行高通量发现抑制性蛋白质片段 |
Savinov, A. |
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N/A |
High-throughput discovery of inhibitory protein fragments with AlphaFold |
| 基于假设的可解释神经网络用于基因间相互作用 |
Wang, S. |
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N/A |
Hypothesis-driven interpretable neural network for interactions between genes |
| 基于假设的可解释神经网络，用于基因间相互作用 |
Wang, S. |
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N/A |
Hypothesis-driven interpretable neural network for interactions between genes |
| 撒哈拉以南非洲地区疟原虫卵形体种群的基因组学研究 |
Carey-Ewend, K. |
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N/A |
Population genomics of Plasmodium ovale species in sub-Saharan Africa |
| 一种用于研究疟原虫主要毒力因子功能研究的系统 |
Cronshagen, J. |
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N/A |
A system for functional studies of the major virulence factor of malaria parasites |
| 细菌受体而非抗噬菌体防御机制决定了一对铜绿假单胞菌裂解噬菌体的宿主范围 |
Mueller, D. M. |
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N/A |
Bacterial Receptors but Not Anti-Phage Defence Mechanisms Determine Host Range for a Pair of Pseudomonas aeruginosa Lytic Phages |
| 人类膀胱癌中自然杀伤细胞功能障碍是由组织特异性抑制SLAMF6信号传导引起的 |
Farkas, A. M. |
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N/A |
Natural Killer Cell Dysfunction In Human Bladder Cancer Is Caused By Tissue-Specific Suppression of SLAMF6 Signaling |
| 与发育滞育的丧失相关的趋同进化可能会促进蜜蜂的寿命延长。 |
Ferreira Santos, P. K. |
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N/A |
Convergent evolution associated with the loss of developmental diapause may promote extended lifespan in bees |
| 胎儿期接触酒精的幼儿，其大脑代谢和兴奋性的改变标志物与执行功能相关。 |
Perdue, M. V. |
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N/A |
Altered markers of brain metabolism and excitability are associated with executive functioning in young children exposed to alcohol in utero |
| 纵向弯曲刚度和中底泡沫对跑步能量学的影响 |
Perry, D. |
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N/A |
Effects of longitudinal bending stiffness and midsole foam on running energetics |
| 人类出生组织产品作为非阿片类药物抑制术后疼痛 |
Zhang, C. |
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N/A |
Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain |
| 评估3xTg-AD小鼠海马中胶质细胞与神经元之间细胞间通讯在两个时间点的改变情况 |
Soelter, T. M. |
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N/A |
Evaluation of altered cell-cell communication between glia and neurons in the hippocampus of 3xTg-AD mice at two time points |
| 人类诺如病毒在人类肠道类器官中培养的见解 |
Ettayebi, K. |
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N/A |
Insights into Human Norovirus Cultivation in Human Intestinal Enteroids |
| 人类血液中携带有噬菌体组，其在克罗恩病中有所不同。 |
Lamy-Besnier, Q. |
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N/A |
The human blood harbors a phageome which differs in Crohn's disease |
| 当环境发生变化时，候鸟会通过观察社会上的收益差异来学习。 |
Chimento, M. |
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N/A |
Immigrant birds learn from socially observed differences in payoffs when their environment changes |
| 一种新型单体淀粉样β激活的信号通路通过抑制小胶质细胞调节大脑发育 |
Kwon, H. |
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N/A |
A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia |
| GeneSpectra：一种跨物种细胞类型基因表达的上下文感知比较方法 |
Song, Y. |
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N/A |
GeneSpectra: a method for context-aware comparison of cell type gene expression across species |
| 贝叶斯系统发育自举法，应用于短树和分支 |
Lemoine, F. |
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N/A |
The Bayesian Phylogenetic Bootstrap, Application to Short Trees and Branches |
| 在小鼠中对SV2A PET配体UCB-J的临床前验证和动力学建模 |
Everix, L. |
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N/A |
Preclinical validation and kinetic modelling of the SV2A PET ligand UCB-J in mice |
| 社会气味促使海马CA2区位置细胞对社会刺激产生反应 |
Robson, E. |
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N/A |
Social odors drive hippocampal CA2 place cell responses to social stimuli |
| 一个表示紧张动作电位尖峰列的数学序列 |
Keum, D. |
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N/A |
A Mathematical Sequence Representing Tonic Action Potential Spike Trains |
| 距离预测的神经表征精度与算术表现相关 |
Zhao, H. |
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N/A |
Neural Representation Precision of Distance Predicts Arithmetic Performance |
| 腹侧视觉通路中细粒度图像和类别信息的范围与限制 |
Badwal, M. W. |
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N/A |
The scope and limits of fine-grained image and category information in the ventral visual pathway |
| 一种用于绘制活体人脑中微观水群和组织弛豫率的定量磁共振成像方法。 |
Filo, S. |
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N/A |
A qMRI approach for mapping microscopic water populations and tissue relaxivity in the in vivo human brain. |
| 生物信息学家、计算机科学家和遗传学家领导生物信息工具开发 - 哪一个更好？ |
Gardner, P. P. |
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N/A |
A Bioinformatician, Computer Scientist, and Geneticist lead bioinformatic tool development - which one is better? |
| "大分化者"属的系统基因组学揭示了岛屿系统中普遍存在的谱系不完全排序、基因流和线粒体捕获现象 |
McCullough, J. |
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N/A |
Phylogenomics of a genus of "Great Speciators" reveals rampant incomplete lineage sorting, gene flow, and mitochondrial capture in island systems |
| 宿主与抗生素共同筛选出金黄色葡萄球菌更强的毒力 |
Su, M. |
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N/A |
Host and antibiotic jointly select for greater virulence in Staphylococcus aureus |
| 临界性是大脑功能的统一设定点吗？ |
Hengen, K. B. |
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N/A |
Is criticality a unified set-point of brain function? |
| 组胺干扰了小鼠的早期视觉处理 |
Tripodi, M. |
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N/A |
Histamine interferes with the early visual processing in mice |
| 特定特征的除法归一化改进了深度感知中自然图像的编码 |
Ni, L. |
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N/A |
Feature-specific divisive normalization improves natural image encoding for depth perception |
| 肩胛间棕色脂肪组织的交感神经支配并不是雄性饮食诱导的肥胖大鼠中OT引发的身体重量增加和脂肪减少的主要介质。 |
Edwards, M. M. |
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N/A |
Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of OT-elicited reductions of body weight gain and adiposity in male diet-induced obese rats |
| 对手在记忆回忆和视觉感知过程中，其视觉空间编码结构在中颞顶叶皮层中响应。 |
Scrivener, C. L. |
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N/A |
Opponent visuospatial coding structures responses during memory recall and visual perception in medial parietal cortex |
| 功能性磁共振成像显示，在大鼠大脑进行五天的局部高密度θ波爆发刺激（hdTBS）后，脑部活动的区域性变化。 |
Li, Q. |
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N/A |
Functional MRI reveals regional changes of brain activity after five days of focal high-density theta burst stimulation (hdTBS) of the rat brain |
| 通过DeepFuseNMF实现空间转录组学数据的可解释高分辨率降维 |
Tang, J. |
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N/A |
Interpretable high-resolution dimension reduction of spatial transcriptomics data by DeepFuseNMF |
| pytom-match-pick：模板匹配中用于自动化分类的tophat-transform约束 |
Chaillet, M. L. |
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N/A |
pytom-match-pick: a tophat-transform constraint for automated classification in template matching |
| 利用高分辨率基因表达谱揭示了被子植物中全基因组加倍后的保守进化响应 |
Leal, J. L. |
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N/A |
Conserved Evolutionary Response to Whole Genome Duplication in Angiosperms Revealed Using High Resolution Gene Expression Profiling |
| 胞质CRISPR RNA用于RNA靶向CRISPR-Cas系统 |
Cheng, E. C. K. |
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N/A |
Cytosolic CRISPR RNA for RNA-targeting CRISPR-Cas systems |
| 基于转录程序的MET外显子14跳跃调控网络解析 |
Truong, M.-J. |
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N/A |
Transcriptional program-based deciphering of the MET exon 14 skipping regulation network |
| 一个从古代口腔微生物群中创建宏基因组组装基因组的高效流程 |
Standeven, F. J. |
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N/A |
An efficient pipeline for creating metagenomic-assembled genomes from ancient oral microbiomes |
| 揭示细胞内Raf抑制剂敏感性的机制基础，揭示协同联合治疗策略 |
Stoddard, E. G. |
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N/A |
Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies |
| 揭示细胞内Raf抑制剂敏感性的机制基础揭示了协同联合治疗策略 |
Stoddard, E. G. |
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N/A |
Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies |
| 贾第鞭毛虫蛋白酶体盖的二元蛋白质相互作用图谱揭示了GlRpn11的额外蛋白酶体功能 |
Das, A. |
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N/A |
The binary protein interactome mapping of the Giardia lamblia proteasome lid reveals extra proteasomal functions of GlRpn11 |
| 从头设计主动旋转和摆动的球形微泡 |
Kaur, V. |
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N/A |
De-novo design of actively spinning and gyrating spherical micro-vesicles |
| 通过声波捕获进行生物聚合物凝聚物的机械表征 |
Nakajima, K. |
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N/A |
Mechanical Profiling of Biopolymer Condensates through Acoustic Trapping |
| 在肾脏中，通过相关超分辨率光学和电子显微镜技术对白蛋白进行定位 |
Birtasu, A. N. |
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N/A |
Localization of Albumin with Correlative Super Resolution Light- and Electron Microscopy in the Kidney |
| Hcm1的动态磷酸化在慢性应激中促进适应性 |
Conti, M. M. |
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N/A |
Dynamic phosphorylation of Hcm1 promotes fitness in chronic stress |
| 细菌噬菌体在健康和克罗恩病中跨肠屏障的差异性易位 |
Douadi, C. |
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N/A |
Differential translocation of bacteriophages across the intestinal barrier in health and Crohn's disease |
| 开发一种细胞通透性强的生物素-HaloTag配体，以探究蛋白质变体在细胞代际间的功能差异 |
Yadav, A. K. |
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N/A |
Development of a cell-permeable Biotin-HaloTag ligand to explore functional differences between protein variants across cellular generations |
| 疾病状态在限制性迁移中的作用 |
Meid, A. |
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N/A |
The role of disease state in confined migration |
| G蛋白偶联受体对mTORC1活性的底物特异性调控 |
Atkinson, S. J. |
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N/A |
Substrate-specific regulation of mTORC1 activity by G protein-coupled receptors |
| RIPK1对于人类细胞中单纯疱疹病毒触发的依赖于ZBP1的坏死性凋亡是必不可少的。 |
Amusan, O. T. |
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N/A |
RIPK1 is essential for Herpes Simplex Virus-triggered ZBP1-dependent necroptosis in human cells |
| CMK-1/CaMKI和TAX-6/Calcineurin在秀丽隐杆线虫的热回避回路中的拮抗作用，共同调控痛觉习惯化过程。 |
Rudgalvyte, M. |
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N/A |
Antagonist actions of CMK-1/CaMKI and TAX-6/Calcineurin along the C. elegans thermal avoidance circuit orchestrate nociceptive habituation |
| 通过定量和行为学研究，揭示了秀丽隐杆线虫觅食过程中的接受-拒绝决策机制。 |
Haley, J. A. |
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N/A |
Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging |
| 鼻内锂氯化物纳米颗粒抑制大脑炎症性细胞焦亡并改善5xFAD小鼠的记忆丧失和抑郁行为 |
Bhuiyan, P. |
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N/A |
Intranasal Lithium Chloride Nanoparticles Inhibit Inflammatory Pyroptosis in Brains and Ameliorate Memory Loss and Depression Behavior in 5xFAD mice |
| 伏隔核星形胶质细胞双向调节社会行为 |
VanRyzin, J. W. |
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N/A |
Nucleus accumbens astrocytes bidirectionally modulate social behavior |
| 皮层-海马相互作用是老年人基于图式的记忆编码的基础 |
Huang, S. |
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N/A |
Cortico-hippocampal interactions underlie schema-supported memory encoding in older adults |
| 猕猴的前侧额叶皮层在不同的学习情境中引导决策 |
Fujimoto, A. |
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N/A |
Ventrolateral prefrontal cortex in macaques guides decisions in different learning contexts |
| 神经元培养基中星形胶质细胞Nrf2的基础激活：神经元-星形胶质细胞建模的挑战与意义 |
Elsharkasi, M. M. O. |
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N/A |
Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling |
| 光遗传学刺激背侧纹状体双向控制癫痫发作 |
Hyder, S. K. |
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N/A |
Optogenetic stimulation of dorsal striatum bidirectionally controls seizures |
| 病毒介导的Oct4过表达与Notch信号通路的抑制协同作用，诱导哺乳动物Müller胶质细胞的神经发生能力。 |
Le, N. |
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N/A |
Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Muller glia. |
| 结合颊部质量平面力学和解剖特征，可以改进海兔摄食行为的神经力学建模。 |
Bennington, M. J. |
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N/A |
Incorporating buccal mass planar mechanics and anatomical features improves neuromechanical modeling of Aplysia feeding behavior |
| 淀粉样β调节小胶质细胞中硫胺素焦磷酸激酶-1表达的机制与后果 |
Cheng, X. |
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N/A |
The mechanism and consequences of amyloid-β modulating thiamine pyrophosphokinase-1 expression in microglia |
| 侧化的小脑连接在小回声定位鲸和非回声定位鲸的听觉通路中有所区别。 |
Flem, S. A. |
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N/A |
Lateralized cerebellar connectivity differentiates auditory pathways in echolocating and non-echolocating whales |
| 脊髓V1中间神经元的转录组图谱揭示了En1在运动输出特定元素中的作用 |
Trevisan, A. J. |
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N/A |
The transcriptomic landscape of spinal V1 interneurons reveals a role for En1 in specific elements of motor output |
| 人类黄斑的形成涉及通过CYP26A1调控的两波视黄酸信号抑制，这调节了细胞周期退出和视锥细胞的特化。 |
Harding, P. |
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N/A |
Human macula formation involves two waves of retinoic acid signaling suppression via CYP26A1 regulating cell cycle exit and cone specification |
| Mylpf 剂量与斑马鱼胚胎中快肌纤维的大小成比例。 |
Adekeye, T. E. |
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N/A |
Mylpf dosage is proportionate to fast-twitch myofibril size in the zebrafish embryo |
| Gα亚单位Gq/11家族对于下颌骨的发育是必要且充分的。 |
Kanai, S. M. |
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N/A |
The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development |
| 情感背景影响有蹄类动物的声纹特征 |
Osiecka, A. N. |
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N/A |
Emotional contexts influence vocal individuality in ungulates |
| 单个神经元电生理记录和计算模型可以预测章鱼手臂的运动。 |
Gedela, N. S. S. |
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N/A |
Single unit electrophysiology recordings and computational modeling can predict octopus arm movement |
| 黑色素瘤表面的陨石坑有助于肿瘤与免疫系统的相互作用，并在人类中显示出对检查点阻断的病理反应。 |
Ludin, A. |
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N/A |
Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans |
| 使用整骨颅骶疗法手动触发自主神经系统反应的特异性研究 |
Keller, M. |
PDF |
N/A |
On the specificity of manual triggers of autonomic nervous system responses using osteopathic cranial manipulative medicine |
| FUS通过液-液相分离介导的MEF2和ETV5招募来控制肌肉分化和结构 |
Picchiarelli, G. |
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N/A |
FUS controls muscle differentiation and structure through LLPS mediated recruitment of MEF2 and ETV5 |
| 环境挑战期间集体社会行为的神经基础 |
Raam, T. |
PDF |
N/A |
Neural basis of collective social behavior during environmental challenge |
| 对比认知、行为和生理反应：在反思室和VR头戴设备环境中，呼吸练习与自然主义刺激的效果 |
Simonian, N. |
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N/A |
Contrasting Cognitive, Behavioral, and Physiological Responses to Breathwork vs. Naturalistic Stimuli in Reflective Chamber and VR Headset Environments |
| 人类神经类器官微生理系统展示了基本学习和记忆所需的构建模块 |
Alam El Din, D.-M. |
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N/A |
Human Neural Organoid Microphysiological Systems Show the Building Blocks Necessary for Basic Learning and Memory |
| α-突触核蛋白预形成纤维诱导的聚集和多巴胺能细胞死亡在组织蛋白酶D过表达和ZKSCAN3敲除小鼠中的研究 |
Mueller, T. |
PDF |
N/A |
Alpha-synuclein preformed fibril-induced aggregation and dopaminergic cell death in cathepsin D overexpression and ZKSCAN3 knockout mice |
| 光学神经影像工作室（OptiNiSt）：一个直观、可扩展、可扩展的光学神经影像数据分析框架 |
Yamane, Y. |
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N/A |
Optical Neuroimage Studio (OptiNiSt): intuitive, scalable, extendable framework for optical neuroimage data analysis |
| 母鼠催产素神经元活动的灵活调节通过微型内窥镜技术揭示 |
Yaguchi, K. |
PDF |
N/A |
Flexible Adjustment of Oxytocin Neuron Activity in Mother Mice Revealed by Microendoscopy |
| 网格细胞信息几何中的速度调制 |
Ye, Z. |
PDF |
N/A |
Speed modulations in grid cell information geometry |
| 删除PTEN（而不是SOCS3或髓鞘抑制因子）显著增强了BRAF诱导的外周感觉轴突脊髓内再生。 |
Kim, H. |
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N/A |
Deleting PTEN, but not SOCS3 or myelin inhibitors, robustly boosts BRAF-elicited intraspinal regeneration of peripheral sensory axons |
| 下丘脑内神经回路调控雄性小鼠交配射精后β-内啡肽的释放 |
Zha, X. |
PDF |
N/A |
Intra-hypothalamic circuit orchestrates β-endorphin release following coital ejaculation in male mice |
| 在小胶质细胞炎症中的铜的作用 |
Craciun, L. |
PDF |
N/A |
Role of copper during microglial inflammation |
| 黑质多巴胺能神经元动作电位形状及树突形态的产后发育 |
Moubarak, E. M. |
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N/A |
Postnatal Development Of Dendritic Morphology And Action Potential Shape In Rat Substantia Nigra Dopaminergic Neurons |
| 眼压升高会损害视神经乳头中的轴突运输，导致神经退行性变，这是在一种新型Cre诱导的肌动蛋白青光眼小鼠模型中发现的。 |
Kaipa, B. R. |
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N/A |
Ocular hypertension impairs axonal transport in the optic nerve head leading to neurodegeneration in a novel Cre-inducible mouse model of myocilin glaucoma. |
| 无监督对齐揭示了自然场景神经表征在个体和脑区之间的结构共性和差异 |
Takeda, K. |
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N/A |
Unsupervised alignment reveals structural commonalities and differences in neural representations of natural scenes across individuals and brain areas |
| 通过ER-Hoxb8条件性永生化巨噬细胞替代小胶质细胞，为深入了解Aicardi-Goutieres综合征的神经病理学提供了新的视角。 |
Nemec, K. M. |
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N/A |
Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutieres Syndrome neuropathology |
| 在经典条件反射过程中，小鼠纹状体纹状体成分中的多巴胺释放对奖励和厌恶结果的反应 |
Yoshizawa, T. |
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N/A |
Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice |
| 利用经皮脊髓刺激开发和评估一种非侵入式脑-脊接口 |
Atkinson, C. J. |
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N/A |
Development and evaluation of a non-invasive brain-spine interface using transcutaneous spinal cord stimulation |
| 视觉词汇的大脑可塑性：小学教师可以在几周内推动的变化，与那些需要数年时间形成的变化相当。 |
Wang, F. |
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N/A |
Brain plasticity for visual words: Elementary school teachers can drive changes in weeks that rival those formed over years |
| 在心脏形成过程中，心包膜作为一个独特的结构形成。 |
Moran, H. R. |
PDF |
N/A |
The pericardium forms as a distinct structure during heart formation |
| 在心脏形成过程中，心包膜作为一个独立的结构形成。 |
Moran, H. R. |
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N/A |
The pericardium forms as a distinct structure during heart formation |
| RFX3对于从多能干细胞衍生的人胰腺胰岛的发育和成熟至关重要。 |
Memon, B. |
PDF |
N/A |
RFX3 is essential for the development and maturation of human pancreatic islets derived from pluripotent stem cells |
| RFX3对于从多能干细胞衍生的人胰腺胰岛的发育和成熟至关重要。 |
Memon, B. |
PDF |
N/A |
RFX3 is essential for the development and maturation of human pancreatic islets derived from pluripotent stem cells |
| 中央纺锤体促进秀丽隐杆线虫锚定细胞的特化、外阴诱导及形态发生。 |
Kato, T. |
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N/A |
Centralspindlin promotes C. elegans anchor cell specification, vulva induction and morphogenesis |
| Sox10Dom/+ 先天性巨结肠小鼠模型中的单细胞分析揭示了 Hoxa6 在肠神经元谱系分配中的作用 |
Avila, J. A. |
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N/A |
Single Cell Profiling in the Sox10Dom/+ Hirschsprung Mouse Implicates Hoxa6 in Enteric Neuron Lineage Allocation |
| Sox10Dom/+ 先天性巨结肠小鼠中单一细胞分析揭示 Hoxa6 在肠神经元谱系分配中的作用 |
Avila, J. A. |
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N/A |
Single Cell Profiling in the Sox10Dom/+ Hirschsprung Mouse Implicates Hoxa6 in Enteric Neuron Lineage Allocation |
| 在加利福尼亚中部城市环境中越冬的穴居猫头鹰（Athene cunicularia hypugaea）到达时间较晚，离开时间较早，偏好有遮蔽的微生境，能耐受雨水，并与多种捕食者竞争。 |
Nicolaus, M. A. |
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N/A |
Athene cunicularia hypugaea wintering in a central California urban setting arrive later, leave earlier, prefer sheltered micro-habitat, tolerate rain, and contend with diverse predators |
| ECSFinder：从基因组序列中优化预测进化保守的RNA二级结构 |
Gaonac'h-Lovejoy, V. A. |
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N/A |
ECSFinder: Optimized prediction of evolutionarily conserved RNA secondary structures from genome sequences |
| 一项关于外生菌根真菌松乳菇（Suillus luteus）本地种群和引入种群局部适应性的实验测试 |
Allen, B. M. |
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N/A |
An Experimental Test of Local Adaptation in Native and Introduced Populations of an Ectomycorrhizal Fungus, Suillus luteus |
| 从头组装自私t超级基因揭示了有害的进化轨迹 |
Runge, J.-N. |
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N/A |
De novo assembly of the selfish t supergene reveals a deleterious evolutionary trajectory |
| 植物根部的细胞间定向运输 |
Jacquier, L. |
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N/A |
Directional Cell-to-cell Transport in Plant Roots |
| 欧洲凤尾鱼生态型形成由不同起源的结构变异和与南方谱系的遗传相互作用驱动 |
Meyer, L. |
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N/A |
Ecotype formation in the European anchovy fuelled by structural variants of different origins and genetic interactions with a southern lineage |
| AyurPhenoClusters确定了罕见疾病的共同分子根源，并揭示了综合征条件下纤毛功能障碍。 |
Joshi, A. |
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N/A |
AyurPhenoClusters define common molecular roots for rare diseases and uncover ciliary dysfunctions in syndromic conditions |
| DNFE：用于检测生物过程中临界点的有向网络流熵 |
Peng, X. |
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N/A |
DNFE: Directed-network flow entropy for detecting the tipping points during biological processes |
| 白垩纪-古近纪大规模灭绝事件中的四足动物物种-面积关系 |
Close, R. A. |
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N/A |
Tetrapod species-area relationships across the Cretaceous-Paleogene mass extinction |
| 综合转录组和代谢组分析揭示了中华蹄盖蕨鳞芽启动和发育的调控机制 |
Yu, A. |
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N/A |
Integrated Transcriptome and Metabolome Analyses Reveal the Mechanism Regulating Bulbil Initiation and Development in Cystopteris chinensis |
| 灵长类新皮层中是否存在普遍的局部场电位功率的光谱层级模式？ |
Mackey, C. A. |
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N/A |
Is there a ubiquitous spectrolaminar motif of local field potential power across primate neocortex? |
| 灵长类新皮层中是否存在普遍的局部场电位功率光谱层级模式？ |
Mackey, C. A. |
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N/A |
Is there a ubiquitous spectrolaminar motif of local field potential power across primate neocortex? |
| β细胞外囊泡PD-L1作为1型糖尿病进展过程中CD8+ T细胞活性的新型调节因子及生物标志物 |
Rao, C. |
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N/A |
Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes |
| 番茄斑萎病毒促进了非媒介性蜘蛛螨种类（Tetranychus urticae 和 Tetranychus evansi）在整个番茄植株上的活动。 |
Gupta, V. |
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N/A |
Tomato spotted wilt virus facilitates non-vector spider mite species (Tetranychus urticae and Tetranychus evansi) on whole tomato plants |
| 不同农业混配助剂的生态毒性 |
Bonn, D. |
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N/A |
Eco-toxicity of different agricultural tank-mix adjuvants |
| 一种世界性植物在其原产地和引入地的气候适应性 |
Albano, L. J. |
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N/A |
Adaptation to climate in the native and introduced ranges of a cosmopolitan plant |
| 大多数野牛牛没有可检测到的野牛遗传祖先。 |
Shapiro, B. |
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N/A |
Most Beefalo cattle have no detectable bison genetic ancestry |
| 线粒体超氧阴离子在肠道中发挥作用，以延长寿命 |
Liontis, T. |
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N/A |
Mitochondrial superoxide acts in the intestine to extend longevity |
| 多重空间映射组织中的染色质特征、转录组和蛋白质 |
Guo, P. |
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N/A |
Multiplexed spatial mapping of chromatin features, transcriptome, and proteins in tissues |
| 基因组分析表明，菌株VE202-06不存在万古霉素耐药性转移的风险。 |
Watson, A. R. |
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N/A |
Genomic Analyses Suggest No Risk of Vancomycin Resistance Transfer by Strain VE202-06 |
| 猴子预测美国大选 |
Jiang, Y. |
PDF |
N/A |
Monkeys Predict US Elections |
| 从有限数据预测蛋白质生物物理特性：通过NanoMelt研究纳米抗体热稳定性的案例 |
Ramon, A. E. |
PDF |
N/A |
Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt |
| 从有限数据预测蛋白质生物物理特性：通过NanoMelt研究纳米抗体热稳定性的案例分析 |
Ramon, A. E. |
PDF |
N/A |
Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt |
| 制造意识生成模型架构能够实现生物序列设计与合成达到千万亿次规模 |
Weinstein, E. N. |
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N/A |
Manufacturing-Aware Generative Model Architectures Enable Biological Sequence Design and Synthesis at Petascale |
| 在植物中既充当隔离子又充当沉默子的小型DNA元件 |
Jores, T. |
PDF |
N/A |
Small DNA elements that act as both insulators and silencers in plants |
| Th17细胞需要DNA修复传感器XPC来控制氧化性DNA损伤。 |
Leite, J. A. |
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N/A |
Th17 cells require the DNA repair sensor XPC to control oxidative DNA damage |
| 抗原漂移过程中H3流感血凝素蛋白的结构和免疫学特性分析 |
de Paiva Froes Rocha, R. |
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N/A |
Structural and immunological characterization of the H3 influenza hemagglutinin during antigenic drift |
| 皮下脂肪组织中肥胖和2型糖尿病性别差异的转录组图谱 |
Moldovan, R. A. |
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N/A |
Transcriptomic landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue |
| 基于硫醇-烯点击反应的策略，用于定制可注射聚合物-纳米颗粒水凝胶的性质，以实现治疗性递送 |
Bailey, S. J. |
PDF |
N/A |
A thiol--ene click-based strategy to customize injectable polymer--nanoparticle hydrogel properties for therapeutic delivery |
| 荧光pH敏感纳米传感器能够在高通量生物工艺制造中实现低体积的精确监测。 |
Besenyei, G. C. |
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N/A |
Fluorescent pH-sensitive nanosensors enable precise low-volume monitoring in high-throughput bioprocess manufacturing |
| 无标记完整硫酸乙酰肝素寡糖的糖组学分析 |
Maciej-Hulme, M. L. |
PDF |
N/A |
Glycoinformatic profiling of label-free intact heparan sulfate oligosaccharides |
| 通过原子级模拟探索生物分子凝聚物中的RNA不稳定机制 |
Boccalini, M. |
PDF |
N/A |
Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic Simulations |
| 在治疗错误折叠疾病的潜在纳米抗体中，构象稳定性和结合亲和力之间缺乏权衡 |
Gomez-Mulas, A. |
PDF |
N/A |
The lack of trade-off between conformational stability and binding affinity in a nanobody with therapeutic potential for a misfolding disease |
| 利用人工神经网络实现分子动力学模拟轨迹的最优存储与便捷共享 |
Wasim, A. |
PDF |
N/A |
Employing Artificial Neural Networks for Optimal Storage and Facile Sharing of Molecular Dynamics Simulation Trajectories |
| 炎症增加以及内质网应激和翻译减少区分了1型糖尿病前症状期胰腺胰岛与非糖尿病病例 |
Swensen, A. C. |
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N/A |
Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases |
| 弓形虫慢性感染通过外周阿片受体信号传导降低内脏痛觉 |
Audibert, A. |
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N/A |
Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling |
| 含LOTUS结构域的蛋白PpLDCP3调控藓类植物小立碗藓的生殖细胞及散布单位的形成 |
Kermanov, A. |
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N/A |
The LOTUS-domain containing protein PpLDCP3 controls germline and dispersal unit formation in the moss Physcomitrium patens |
| 基于光纤布拉格光栅的非破坏性根系表型分析系统，采用ResNet预测 |
Binder, S. |
PDF |
N/A |
Fiber Bragg grating based sensing system for non-destructive root phenotyping using ResNet prediction |
| 早期分化被子植物中的基因组印记揭示了开花植物种子起始的古老机制 |
Florez-Rueda, A. M. |
PDF |
N/A |
Genomic imprinting in an early-diverging angiosperm reveals ancient mechanisms for seed initiation in flowering plants |
| 肌醇多磷酸盐调控绿藻莱茵衣藻中的弹性机制，以适应极端营养条件。 |
Bedera-Garcia, R. |
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N/A |
Inositol polyphosphates regulate resilient mechanisms in the green alga Chlamydomonas reinhardtii to adapt to extreme nutrient conditions |
| 植物对小麦瘿螨和小麦条锈病毒（WSMV）的反应：小麦对病毒耐受性的首次证据 |
Pingault, L. |
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N/A |
Plant responses to wheat curl mites and wheat streak mosaic virus (WSMV): first evidence of virus tolerance in wheat |
| 双链RNA对埃及列当（Phelipanche aegyptiaca）种子萌发的非特异性效应 |
Zainali, N. |
PDF |
N/A |
Non-specific effect of double-stranded RNAs on Egyptian broomrape (Phelipanche aegyptiaca) seed germination |
| 通过基于CRISPR/Cas9 RNP的植物体内基因编辑技术培育出的长保质期甜瓜 |
Sasaki, K. |
PDF |
N/A |
A long shelf-life melon created via CRISPR/Cas9 RNP-based in planta genome editing |
| PGR5促进依赖能量的非光化学淬灭，以在波动光照下实现高效的C4光合作用。 |
Woodford, R. |
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N/A |
PGR5 promotes energy-dependent non-photochemical quenching to enable efficient C4 photosynthesis under fluctuating light |
| 在拟南芥中，昼夜和发育时间尺度上的稳定且动态的基因表达模式 |
Redmond, E. J. |
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N/A |
Stable and dynamic gene expression patterns over diurnal and developmental timescales in Arabidopsis thaliana |
| 通过基因组编辑调控下游保守非编码序列，优化TAWAWA1介导的水稻穗型结构 |
Kuroha, T. |
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N/A |
Fine-Tuning TAWAWA1-Mediated Panicle Architecture by Genome Editing of a Downstream Conserved Noncoding Sequence in Rice |
| 遮荫通过SPL16/SPL23介导的细胞分裂素途径抑制杨树茎的形成层活动 |
Wei, H. |
PDF |
N/A |
Shade Inhibits Cambial Activity in Populus Stems by the SPL16/SPL23-Mediated Cytokinin Pathway |
| 植物BCL-Domain同源物在SWI/SNF复合体的稳定性中发挥着保守的作用。 |
Candela-Ferre, J. |
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N/A |
Plant BCL-Domain Homologues play a conserved role in SWI/SNF complex stability |
| 绿色藻类在适应有限二氧化碳环境时，二氧化碳浓缩机制与光呼吸的联合运作 |
Dao, O. |
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N/A |
Joint operation of the CO2 concentrating mechanism and photorespiration in green algae during acclimation to limiting CO2 |
| 拟南芥AtGELP53通过寡糖介导的信号调节多糖乙酰化和防御反应 |
Rastogi, L. |
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N/A |
Arabidopsis AtGELP53 modulates polysaccharide acetylation and defense response through oligosaccharide-mediated signaling |
| 在叶绿体中工程化Rubisco凝聚以调控植物光合作用 |
Chen, T. |
PDF |
N/A |
Engineering Rubisco Condensation in Chloroplasts to Manipulate Plant Photosynthesis |
| 利用番茄相关细菌群落进行细菌性枯萎病的生物防治 |
Tanaka, E. |
PDF |
N/A |
Biocontrol of bacterial wilt disease using plant-associated bacterial communities in tomato |
| M2巨噬细胞来源的外泌体通过抑制髓系细胞中的I型干扰素信号，逆转了饮食诱导心肌梗死小鼠的心脏功能下降。 |
Ng, M. |
PDF |
N/A |
M2 Macrophage Exosomes Reverse Cardiac Functional Decline in Mice with Diet-Induced Myocardial Infarction by Suppressing Type 1 Interferon Signaling in Myeloid Cells |
| 多种平台稳定化的HIV-1 C亚型儿童包膜糖蛋白的设计与免疫原性研究 |
Kumar, S. |
PDF |
N/A |
Design and immunogenicity of an HIV-1 clade C pediatric envelope glycoprotein stabilized by multiple platforms |
| 脑内AAV给药后诱导的针对衣壳的抗体以剂量依赖的方式限制了第二次给药 |
Xu, Y.-G. |
PDF |
N/A |
Antibodies against the capsid induced after intracranial AAV administration limits second administration in a dose dependent manner |
| TREM2-p53信号轴活动中的遗传变异决定了氧气诱导的肺损伤 |
Abe, Y. |
PDF |
N/A |
Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-inducedlung injury |
| 古DNA揭示了大西洋蓝鳍金枪鱼的历史人口下降和遗传侵蚀 |
Andrews, A. J. |
PDF |
N/A |
Ancient DNA reveals historical demographic decline and genetic erosion in the Atlantic bluefin tuna |
| 微气候传感器网络的工作流程：整合地理工具、统计数据和地方知识 |
Klinges, D. H. |
PDF |
N/A |
A workflow for microclimate sensor networks: integrating geographic tools, statistics, and local knowledge |
| 剖析热带雨林中的蚯蚓多样性 |
Goulpeau, A. |
PDF |
N/A |
Dissecting earthworm diversity in tropical rainforests |
| 软壳蛤（Mya arenaria）可传播癌症中的基因表达揭示了其在宿主感染和海水转移过程中的生存机制 |
Hart, S. F. M. |
PDF |
N/A |
Gene expression in soft-shell clam (Mya arenaria) transmissible cancer reveals survival mechanisms during host infection and seawater transfer |
| 革兰氏阴性细菌中肽聚糖O-乙酰化的机制典型地体现了细菌MBOAT-SGNH酰基转移酶的作用方式。 |
Anderson, A. C. |
PDF |
N/A |
The mechanism of peptidoglycan O-acetylation in Gram-negative bacteria typifies bacterial MBOAT-SGNH acyltransferases |
| LiverMap 管道用于人体肝脏的三维成像，揭示了肝硬化血管胆道结构的体积空间失调。 |
Fabyan, W. B. |
PDF |
N/A |
LiverMap pipeline for 3D imaging of human liver reveals volumetric spatial dysregulation of cirrhotic vasculobiliary architecture |
| 通过可编程熵在平衡态下的分子计算 |
Wang, B. |
PDF |
N/A |
Molecular computation at equilibrium via programmable entropy |
| 基于聚丙烯酰胺的抗菌共聚物，能够抵御典型抗药性机制，用于替代或挽救抗生素 |
Williams, S. C. |
PDF |
N/A |
Polyacrylamide-based Antimicrobial Copolymers Immune to Typical Resistance Mechanisms to Replace or Rescue Antibiotics |
| QuickEd：基于边界与对齐的高性能精确序列比对 |
Doblas, M. |
PDF |
N/A |
QuickEd: High-performance exact sequence alignment based on bound-and-align |
| 对大规模生物医学数据进行聚类，以建模疾病进展和抗微生物药物抗性进化中的动态积累过程 |
Dauda, K. A. |
PDF |
N/A |
Clustering large-scale biomedical data to model dynamic accumulation processes in disease progression and anti-microbial resistance evolution |
| 全面绘制左旋多巴与帕金森病中铁代谢相互作用图谱 |
Wang, J. |
PDF |
N/A |
Comprehensive mapping of the Interaction of levodopa and iron metabolism in Parkinson's disease |
| 利用大型语言模型提升基于生物标志物的肿瘤学试验匹配 |
Al Khoury, N. |
PDF |
N/A |
Enhancing Biomarker-Based Oncology Trial Matching Using Large Language Models |
| 侧链化学编码的凝聚物固/液相变 |
Chen, F. |
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N/A |
Sidechain chemistry-encoded solid/liquid phase transitions of condensates |
| 蠕动泵触发的淀粉样蛋白形成表明剪切应力是淀粉样蛋白成核的在体风险因素 |
Goto, Y. |
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N/A |
Peristaltic pump-triggered amyloid formation suggests shear stresses are in vivo risk factors of amyloid nucleation |
| 负电荷，而非必需的磷酸化，是14-3-3蛋白识别配体所必需的 |
Kamayirese, S. |
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N/A |
Negative Charges, Not Necessary Phosphorylation, are Required for Ligand Recognition by 14-3-3 Proteins |
| α-突触核蛋白高分辨率冷冻电镜结构测定 - 一种典型的淀粉样纤维 |
Sanchez, J. C. |
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N/A |
High-Resolution Cryo-EM Structure Determination of α-Synuclein - A Prototypical Amyloid Fibril |
| 张力诱导的变构构象变化抑制解释了动力蛋白-1的协调步进 |
Makino, T. |
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N/A |
Tension-induced suppression of allosteric conformational changes explains coordinated stepping of kinesin-1 |
| 驱动蛋白的两个马达结构域的动力学调控协调其在微管上的步进运动 |
Niitani, Y. |
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N/A |
Kinetic regulation of kinesin's two motor domains coordinates its stepping along microtubules |
| 来自2型糖尿病患者的血浆外泌体可促进乳腺癌在患者来源的类器官中的侵袭性 |
Ennis, C. S. |
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N/A |
Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids |
| 通过阻断FoxO3a的Neddylation，Epac1的药理学抑制对肺纤维化具有保护作用 |
Jankowski, K. |
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N/A |
Pharmacological Inhibition of Epac1 Protects against Pulmonary Fibrosis by Blocking FoxO3a Neddylation |
| 一种无需灌胃的小鼠口服葡萄糖耐量测试精细方案的验证 |
Pye, K. R. |
PDF |
N/A |
Validation of a refined protocol for mouse oral glucose tolerance testing without gavage |
| RFdiffusion在预测真菌病原体与谷类作物间蛋白质相互作用中的应用 |
Haley, O. C. |
PDF |
N/A |
Application of RFdiffusion to predict interspecies protein-protein interactions between fungal pathogens and cereal crops |
| 细胞大小稳态的广义加法机制：对克隆增殖随机动力学的启示 |
Nieto, C. |
PDF |
N/A |
A Generalized Adder mechanism for Cell Size Homeostasis: Implications for Stochastic Dynamics of Clonal Proliferation |
| 合并逻辑模型：在急性髓系白血病建模中的应用 |
Li, L. X. |
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N/A |
Merging logical models: An application in Acute Myeloid Leukemia modeling |
| WEE1抑制剂延缓了雌激素受体阳性乳腺癌对CDK4/6抑制剂和抗雌激素治疗的耐药性 |
He, W. |
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N/A |
WEE1 inhibition delays resistance to CDK4/6 inhibitor and antiestrogen treatment in estrogen receptor-positive breast cancer |
| 实验室条件下饲养智利小植绥螨的优化 |
Nguyen, H. |
PDF |
N/A |
Optimization of rearing Transeius montdorensis under laboratory conditions |
| 第三型分泌系统诱导的液泡膜机械穿孔 |
SWISTAK, L. |
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N/A |
TYPE THREE SECRETION SYSTEM-INDUCED MECHANOPORATION OF VACUOLAR MEMBRANES |
| T6SS DNase效应因子通过激活cGAS-STING-TNF轴引发核DNA损伤，从而触发细胞凋亡。 |
Song, L. |
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N/A |
A T6SS DNase effector induces nuclear DNA Damage to trigger apoptosis via activation of the cGAS-STING-TNF axis |
| 不同生活方式在真菌界中的生物合成基因簇变异 |
Allen, B. M. |
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N/A |
Variation in Biosynthetic Gene Clusters Among Lifestyles Across Kingdom Fungi |
| 常见膳食蛋白质成分的N-糖组谱的鉴定与比较 |
Bolino, M. |
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N/A |
Identification and comparison of N-glycome profiles from common dietary protein ingredients |
| 高通量元分析抗菌肽以鉴定类别特异性治疗候选者：一种计算机方法 |
Agrawal, P. |
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N/A |
High Throughput Meta-analysis of Antimicrobial Peptides for Characterizing Class Specific Therapeutic Candidates: An in-silico Approach |
| FLIMPA：一种适用于荧光寿命成像显微镜相量分析的多功能软件 |
Kapsiani, S. |
PDF |
N/A |
FLIMPA: A versatile software for Fluorescence Lifetime Imaging Microscopy Phasor Analysis |
| 染色体不稳定性增加辐射敏感性 |
Cosper, P. F. |
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N/A |
Chromosomal instability increases radiation sensitivity |
| 一种综合的超高效液相色谱-串联质谱（UHPLC-MS/MS）和提取方法，用于菠菜（Spinacia oleracea）中的黄酮类化合物 |
Dzakovich, M. P. |
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N/A |
A Comprehensive UHPLC-MS/MS and Extraction Method for Spinach (Spinacia oleracea) Flavonoids |
| 铬还原细菌Bacillus tropicus的特性及分子机制研究 |
Tuli, S. R. |
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N/A |
Characterization and molecular insights of a chromium-reducing bacterium Bacillus tropicus |
| 金黄色葡萄球菌噬菌体phi812的细胞附着与尾部收缩 |
Binovsky, J. |
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N/A |
Cell attachment and tail contraction of S. aureus phage phi812 |
| 一种珊瑚肽对全球海洋病原体——溶珊瑚弧菌具有杀菌活性。 |
Aoyama, K. |
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N/A |
A coral peptide has bactericidal activity against a global marine pathogen, Vibrio coralliilyticus |
| 多通道游戏中复式网络上的合作演化 |
Basak, A. |
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N/A |
Evolution of cooperation in multichannel games on multiplex networks |
| 机器学习时代的整合建模：HADDOCK策略在CAPRI第47至55轮中的总结 |
Reys, V. |
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N/A |
Integrative modeling in the age of machine learning: a summary of HADDOCK strategies in CAPRI rounds 47-55 |
| 新鲜人视网膜单细胞RNA测序图谱揭示了一种新型视锥细胞亚型及细胞多样性 |
Yang, L. |
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N/A |
Fresh Human Retinal scRNA-seq Atlas Reveals a Novel Cone Subtype and Cellular Diversity |
| 固定剂灌注前后神经组织制备质量的比较研究 |
Meyer-Dilhet, G. |
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N/A |
Comparative study of pre- and post-mortem perfusion of fixative for the quality of neuronal tissue preparation |
| 零回波时间成像实现了在小鼠中进行全脑活动图谱绘制，同时避免了腹侧信号的损失。 |
Imamura, A. |
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N/A |
Zero-echo time imaging achieves whole brain activity mapping without ventral signal loss in mice |
| 果蝇中的神经元同步 |
Fernandez-Chiappe, F. |
PDF |
N/A |
Neuronal synchronization in Drosophila |
| 色素分散因子对蚊子宿主搜寻持久性的昼夜调节影响每日叮咬模式 |
Dong, L. |
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N/A |
Circadian modulation of mosquito host-seeking persistence by Pigment-Dispersing Factor impacts daily biting patterns |
| 生成一种可诱导的不稳定结构域Cre小鼠品系，以靶向疾病相关的小胶质细胞 |
Henningfield, C. M. |
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N/A |
Generation of an inducible destabilized-domain Cre mouse line to target disease associated microglia |
| 氧化应激的隔离是必要的，但不足以得出姜黄素对多巴胺能神经的保护作用：来自ALSS果蝇帕金森病模型的见解 |
Phom, L. |
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N/A |
Sequestration of oxidative is necessary but not sufficient enough to conclude dopaminergic neuroprotective efficacy of curcumin: Insights from ALSS Drosophila Parkinson disease model |
| 视觉引导伸手过程中参考框架间方向和距离的神经编码 |
Harris Caceres, A. |
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N/A |
Neural Encoding of Direction and Distance across Reference Frames in Visually Guided Reaching |
| 基于SENP2的α-突触核蛋白N端截短在路易体病理传播中的作用 |
Taguchi, K. |
PDF |
N/A |
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation |
| PARP1对ADP-核糖基化的全球重塑抑制了甲型流感病毒感染 |
Zhang, Z. |
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N/A |
Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection |
| 微生物硫氧化菌和氨氧化菌在沿海海底生态状态中的关键作用 |
Nilsen, T. |
PDF |
N/A |
Key roles of microbial sulfur and ammonium oxidizers for the coastal seafloor ecological state |
| 液滴测序揭示口腔生物膜外泌体中的毒力基因簇 |
Takano, S. |
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N/A |
Droplet Sequencing Reveals Virulence Gene Clusters in Oral Biofilm Extracellular Vesicles |
| 通过lncRNA T-UCstem1依赖于DKK1调控WNT信号通路，实现对胚胎发育的非细胞自主性控制 |
Coppola, A. |
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N/A |
Non-cell-autonomous control of gastruloid development by the lncRNA T-UCstem1 through DKK1-dependent modulation of WNT signalling |
| 从基因到模式：一个建模胚胎发育从转录调控中涌现的框架 |
Garcia-Guillen, J. |
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N/A |
From Genes to Patterns: A Framework for Modeling the Emergence of Embryonic Development from Transcriptional Regulation |
| 利用基因组和线粒体数据揭示的濒危物种西伯利亚鼯鼠（Pteromys volans）的种群结构 |
Ito dos Santos, F. |
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N/A |
Population structure of the endangered Siberian flying squirrel (Pteromys volans) revealed by genomic and mitochondrial data |
| 短期抗生素、诱导磁场与迁徙鸣禽的磁感应能力 |
Sherf, G. |
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N/A |
Short-term antibiotics, induced magnetic field, and magnetic sensitivity in a migratory songbird |
| 一种快速、廉价、无培养、普适性的细菌鉴定系统，采用内部转录间隔区靶向引物：一项原理验证研究 |
Asthana, V. |
PDF |
N/A |
A rapid, inexpensive, culture-free, universal bacterial identification system using internal transcribed spacer targeting primers: a proof-of-principle study |
| DuReS：一个用于去噪基于实验性串联质谱代谢组学数据的R包 |
Banerjee, S. |
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N/A |
DuReS: An R package for denoising experimental tandem mass spectrometry-based metabolomics data |
| 晚发性阿尔茨海默病中内嗅皮层和海马基因的差异调控 |
Biswas, M. |
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N/A |
DIFFERENTIAL REGULATION OF GENES IN ENTORHINAL CORTEX AND HIPPOCAMPUS IN LATE ONSET AD |
| CelloType：一种用于组织图像分割与分类的统一模型 |
Pang, M. |
PDF |
N/A |
CelloType: A Unified Model for Segmentation and Classification of Tissue Images |
| 单细胞多模态组学整合方法的多任务基准测试 |
Liu, C. |
PDF |
N/A |
Multi-task benchmarking of single-cell multimodal omics integration methods |
| 利用加权四联体分布增强全基因组数据物种树推断 |
Hasan, N. B. |
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N/A |
Leveraging weighted quartet distributions for enhanced species tree inference from genome-wide data |
| 轨迹引导的降维方法用于多样本单细胞RNA测序数据，揭示了具有生物学意义的样本间异质性 |
Zhuang, H. |
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N/A |
Trajectory-guided dimensionality reduction for multi-sample single-cell RNA-seq data reveals biologically relevant sample-level heterogeneity |
| STAG2-PAXIP1/PAGR1轴抑制肺肿瘤发生 |
Ashkin, E. L. |
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N/A |
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis |
| 分子磁共振成像检测锌分泌失调可早期发现胰腺导管腺癌病变及对KRASG12D抑制剂治疗的反应 |
Jordan, V. C. |
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N/A |
Molecular Magnetic Resonance Imaging of Dysregulated Zinc Secretion Detects Early Pancreatic Ductal Adenocarcinoma Lesions and Response to KRASG12D Inhibitor Treatment |
| 黑皮质素-4受体拮抗剂TCMCB07缓解化疗引起的厌食和体重下降 |
Zhu, X. |
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N/A |
Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss |
| 低强度电肌肉刺激对废用一周后大腿和小腿肌肉基因表达和表型的多向效应 |
Borzykh, A. A. |
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N/A |
Multidirectional effect of low-intensity electrical myostimulation on gene expression and phenotype in thigh and calf muscles after one week of disuse |
| PMR4胼胝质合酶的缺失导致拟南芥和油菜对根肿病的抗性不依赖于水杨酸且具有广谱性 |
Luo, B. |
PDF |
N/A |
Loss of PMR4 callose synthase results in salicylic acid-independent and broad-spectrum resistance to clubroot in Arabidopsis and Brassica napus |
| 密度依赖性彩色扫描电子显微镜（DDC-SEM）。在钙化组织研究中的应用及视觉影响。 |
Tsolaki, E. |
PDF |
N/A |
Density-Dependent Colour Scanning Electron Microscopy (DDC-SEM). Applications in the study of calcified tissues and visual impact. |
| 体内酶选择系统的代谢生长耦合策略 |
Alter, T. B. |
PDF |
N/A |
Metabolic growth coupling strategies for in vivo enzyme selection systems |
| 通过建模评估植物生长与防御之间的权衡关系，探讨初级代谢与次级代谢之间的相互作用 |
Zrimec, J. |
PDF |
N/A |
Evaluating plant growth-defence trade-offs by modelling the interaction between primary and secondary metabolism |
| Cnes2b 调控宿主对隐球菌感染的抵抗力、炎症反应及组织损伤 |
Angers, I. |
PDF |
N/A |
Cnes2b Regulates Host Resistance, Inflammatory Responses and Tissue Damage Following Cryptococcus deneoformans Infection |
| 缺氧介导的TLR7/9触发的人类浆细胞样树突状细胞（PDC）衍生的IFN-α反应的精细调控是通过细胞内和可溶性IFN调节因子的联合作用实现的。 |
Lenkewitz, A. |
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N/A |
Hypoxia-mediated fine-tuning of the TLR7/9-triggered human PDC-derived IFN-α response is mediated by combined cellular and soluble IFN-regulators |
| 在斑马鱼神经杆内局部光遗传激活NMYII会导致长距离、不对称的力传播 |
Crellin, H. A. |
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N/A |
Local optogenetic NMYII activation within the zebrafish neural rod results in long-range, asymmetric force propagation |
| 意外的是，一种多蚁后超级基因单倍型在蚁群超群体的Formica蚂蚁种群中缺失。 |
Lagunas-Robles, G. |
PDF |
N/A |
Unexpected absence of a multiple-queen supergene haplotype from supercolonial populations of Formica ants |
| 性别、发育和营养依赖的北大西洋鲑鱼主要成熟年龄基因表达 |
Asheim, E. R. |
PDF |
N/A |
Sex-, development-, and nutrition-dependent expression of a major age-at-maturity gene in Atlantic salmon |
| 番木瓜（番木瓜科）性别决定相关单核苷酸变异效应的预测 |
Spelta, J. V. V. B. |
PDF |
N/A |
PREDICTION OF SINGLE NUCLEOTIDE VARIANT EFFECTS RELATED TO SEX DETERMINATION IN Carica papaya (Caricaceae) |
| 在存在胞嘧啶转换错误的情况下进行亚硫酸氢盐测序 |
Ellis, T. J. |
PDF |
N/A |
Bisulphite sequencing in the presence of cytosine-conversion errors |
| 抗菌潜力与圣罗勒提取物合成银纳米粒子的表征 |
Sulaiman, M. |
PDF |
N/A |
Antimicrobial Potential and Characterization of Silver Nanoparticles Synthesized from Ocimum Sanctum Extract |
| 滤波器组公共空间模式与基于包络的特征在多模态EEG-fTCD脑机接口中的应用 |
Khalaf, A. |
PDF |
N/A |
Filter bank common spatial pattern and envelope-based features in multimodal EEG-fTCD brain-computer interfaces |
| 管道奥运会：针对DNA甲基化测序数据的计算工作流程的可连续基准测试，与实验金标准进行对比 |
Lin, Y.-Y. |
PDF |
N/A |
Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold-standard |
| 低级别胶质瘤中IDH1状态和1p/19q共缺失分类的放射组学与连接组学方法比较研究 |
Paradkar, R. V. |
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N/A |
A Comparative Study of Radiomic and Connectomic Approaches to Classification of IDH1 Status and 1p/19q Co-deletion in Lower Grade Gliomas |
| GWA-X：一个可扩展的GPU加速包，用于全基因组关联研究中的排列检验 |
Agung, M. |
PDF |
N/A |
GWA-X: An Extensible GPU Accelerated Package for Permutation Testing in Genome-Wide Association Studies |
| 利用公开的数据非依赖性采集数据集对人类组织中基线蛋白质表达的综合视图 |
Prakash, A. |
PDF |
N/A |
Integrated View of Baseline Protein Expression in Human Tissues using public Data Independent Acquisition datasets |
| Humatch - 快速、基因特异性抗体重链和轻链联合人源化 |
Chinery, L. |
PDF |
N/A |
Humatch - fast, gene-specific joint humanisation of antibody heavy and light chains |
| 利用HetSIREN在实空间中对CryoEM构象状态进行异质性重构、精炼与解耦 |
Herreros, D. |
PDF |
N/A |
Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN |
| SIRPalpha+ PD-L1+ 骨髓巨噬细胞通过调节T细胞功能促进AML生长 |
Birch, F. |
PDF |
N/A |
SIRPalpha+ PD-L1+ bone marrow macrophages aid AML growth by modulating T cell function |
| 水通道蛋白-4的表达水平和定位异常与不同侵袭性胶质瘤的瘤周水肿呈负相关。 |
Valente, O. |
PDF |
N/A |
Aquaporin-4 expression levels and mis-localization are inversely linked to peritumoral edema in gliomas of varying aggressiveness |
| DNA聚合酶θ介导的DNA修复是DNMT3A缺陷型白血病细胞的功能依赖性和治疗脆弱性 |
Le, B. V. |
PDF |
N/A |
DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells |
| 小鼠中PI3K持续激活和Pten缺失导致的睾丸性索间质肿瘤 |
Dinevska, M. |
PDF |
N/A |
Testicular sex cord stromal tumors in mice with constitutive activation of PI3K and loss of Pten |
| TAU 20成功刺激心肌神经节丛，且未造成心脏损伤 |
Li, S. |
PDF |
N/A |
Successful stimulation of myocardial ganglionic plexuses by TAU 20 in the absence of cardiac damage |
| 代谢建模揭示了IBD中宿主-微生物组代谢网络的多层次失调 |
Taubenheim, J. |
PDF |
N/A |
Metabolic modeling reveals a multi-level deregulation of host-microbiome metabolic networks in IBD |
| 心脏-肿瘤模型中免疫检查点抑制剂治疗的最优控制 |
van der Vegt, S. |
PDF |
N/A |
Optimal control of immune checkpoint inhibitor therapy in a heart-tumour model |
| 阐明早期肠道干细胞对细菌感染的反应 |
Lebon, S. |
PDF |
N/A |
Elucidating early intestinal stem cell response to bacterial infection |
| 预测蛋白质靶向嵌合体的降解潜力 |
Petrou, A. |
PDF |
N/A |
Predicting Degradation Potential of Protein Targeting Chimeras |
| BayesAge 2.0：一种用于预测转录组年龄的最大似然算法 |
Pellegrini, M. |
PDF |
N/A |
BayesAge 2.0: A Maximum Likelihood Algorithm To Predict Transcriptomic Age |
| 变体评分在不同选择体制下的表现取决于变体与基因以及基因与疾病之间的关系。 |
Finucane, H. K. |
PDF |
N/A |
Variant scoring performance across selection regimes depends on variant-to-gene and gene-to-disease components |
| 基于深度学习的基因扰动效应预测尚未超越简单的线性方法。 |
Ahlmann-Eltze, C. |
PDF |
N/A |
Deep learning-based predictions of gene perturbation effects do not yet outperform simple linear methods |
| 用于结构系统发育学的一般替代矩阵。 |
Garg, S. G. |
PDF |
N/A |
A general substitution matrix for structural phylogenetics. |
| ArchMap：一个基于网络的平台，用于基于参考的单细胞数据集分析 |
Lotfollahi, M. |
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N/A |
ArchMap: A web-based platform for reference-based analysis of single-cell datasets |
| 基准测试酶中运输通道研究中的粗粒度模拟方法 |
Mandal, N. |
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Benchmarking coarse-grained simulation methods for investigation of transport tunnels in enzymes |
| 细菌基因型预测的深度视频分析 |
Dabouei, A. |
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Deep Video Analysis for Bacteria Genotype Prediction |
| 嘌呤相互作用在生物矿物晶体形状决定中的作用 |
Rothkegel, J. |
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The Role of Purine Interactions in Biogenic Crystal Shape Determination |
| 肌肉纤维蛋白质组学揭示了性别和纤维类型特异性对阻力训练的适应 |
Moesgaard, L. |
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Muscle fiber proteomics reveals sex- and fiber type-specific adaptations to resistance training |
| 共享选择和遗传结构共同驱动了长期实验杂交种群中显著可重复的进化 |
Owens, G. L. |
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Shared selection and genetic architecture drive strikingly repeatable evolution in long-term experimental hybrid populations |
| 优化的CRISPR抑制和激活为斑马鱼系统生物学探索开辟了关键途径。 |
Barrientos, N. B. |
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Optimized CRISPR inhibition and activation opens key avenues for systematic biological exploration in zebrafish. |
| 染色质折叠模式定义了单等位基因中TAD结构的基本语法 |
Messina, O. |
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Chromatin folding motifs define the basic grammar of TAD architecture in single alleles |
| 人类4D核组结构与功能的综合视角 |
The 4D Nucleome Consortium, |
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An integrated view of the structure and function of the human 4D nucleome |
| 一个可访问的平台，用于量化载细胞水凝胶中的氧气扩散，并将其应用于海藻酸盐固定的胰腺β细胞 |
Champion, K. |
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An accessible platform to quantify oxygen diffusion in cell-laden hydrogels and its application to alginate-immobilized pancreatic beta cells |
| 稳健的CRISPR/dCas13 RNA阻断器能够特异性地干扰miRNA与其靶标的相互作用，并能拯救1型肌强直性营养不良病理 |
Hanifi, M. |
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Robust CRISPR/dCas13 RNA blockers specifically perturb miRNA-target interactions and rescue type 1 myotonic dystrophy pathology |
| 蛋白质pKa的精确快速预测：蛋白质语言模型揭示序列-pKa关系 |
Xu, S. |
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Accurate and Rapid Prediction of Protein pKa: Protein Language Models Reveal the Sequence-pKa Relationship |
| 一种战略性混合稳定聚合物，用于控制颗粒表面电荷，以增强粘液传输和细胞结合 |
Stevens, C. A. |
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A Strategic Blend of Stabilizing Polymers to Control Particle Surface Charge for Enhanced Mucus Transport and Cell Binding |
| 降低硫化氢生物利用度有助于保留射血分数的心脏代谢性心力衰竭 |
Doiron, J. |
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Reduced Hydrogen Sulfide Bioavailability Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction |
| 外周阿片受体拮抗作用可缓解芬太尼引起的心血管呼吸抑制，且无厌恶效应。 |
Ruyle, B. |
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Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive effects |
| SARS-CoV-2在皮肤上的存活及其从污染表面的转移 |
Pitol Garcia, A. K. |
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SARS-CoV-2 Survival on Skin and its Transfer from Contaminated Surfaces |
| Maf家族bZIP转录因子NRL与视网膜光感受器中的RNA结合蛋白及R环相互作用 |
Corso Diaz, X. |
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Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors |
| 利用计算分子网络工具对亨特利亚伞形叶甲醇和生物碱提取物中的次生代谢物进行研究 |
Adedeji, R. A. |
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INVESTIGATION OF SECONDARY METABOLITES PRESENT IN METHANOLIC AND ALKALOIDAL EXTRACTS OF HUNTERIA UMBELLATA LEAVES USING COMPUTATIONAL MOLECULAR NETWORKING TOOL |
| 唑类与非唑类药物激活白色念珠菌Pdr1调控通路的异同 |
Conway, T. P. |
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Similarities and distinctions in the activation of the Candida glabrata Pdr1 regulatory pathway by azole and non-azole drugs |
| 结构导向的工程改造：针对人类细胞靶向基因插入的I-F型CASTs |
Lampe, G. D. |
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Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells |
| 与导致人类疟疾的动物源病原体疟原虫（Plasmodium knowlesi）相关的病毒属于一个多样且未分类的病毒分类单元。 |
Petrone, M. E. |
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A virus associated with the zoonotic pathogen Plasmodium knowlesi causing human malaria is a member of a diverse and unclassified viral taxon |
| 在免疫细胞命运转换过程中，IRF8和FOS增强子对的协同和拮抗作用 |
Klonizakis, A. |
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Synergistic and antagonistic activities of IRF8 and FOS enhancer pairs during an immune cell fate switch |
| 亚塔霉素生物合成需要两种脱氧核糖核酸酶来实现毒素自我抗性。 |
Dorival, J. |
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Yatakemycin biosynthesis requires two deoxyribonucleases for toxin self-resistance |
| 分子水平解析电梯型金属转运蛋白中的底物转运机制 |
Jafari, M. |
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Molecular insights into substrate translocation in an elevator-type metal transporter |
| HDgraphiX：一种用于可视化氢氘交换质谱数据的基于网络的工具 |
Vosper, K. R. |
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HDgraphiX: A web-based tool for visualization of hydrogen deuterium exchange mass spectrometry data |
| 使用高分辨率质谱法进行小肠和粪便代谢组学分析的无靶向和半靶向代谢组学方法 |
TRONEL, a. |
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Untargeted and Semi-Targeted Metabolomics Approach for Profiling Small Intestinal and Fecal Metabolome Using High-Resolution Mass Spectrometry |
| 构象灵活性是设计广谱人诺如病毒蛋白酶抑制剂的关键因素。 |
Pham, S. H. |
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Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors |
| 克莱兰免疫印迹揭示了意想不到的半胱氨酸氧化蛋白质形式 |
Cobley, J. N. |
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Cleland Immunoblotting Unmasks Unexpected Cysteine Redox Proteoforms |
| SCA5突变在β-III-血影蛋白的血影蛋白重复域中的分子后果 |
Denha, S. |
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Molecular consequences of SCA5 mutations in the spectrin-repeat domains of beta-III-spectrin |
| 人类核糖体通过延迟共翻译域对接来调节多结构域蛋白的生物合成。 |
Pellowe, G. A. |
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The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking |
| 微晶电子衍射（MicroED）结构揭示了氟替卡松糠酸酯和氟替卡松丙酸酯的新功能见解 |
Lin, J. |
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MicroED Structures of Fluticasone Furoate and Fluticasone Propionate Provide New Insights to Their Function |
| 人类半胱氨酸氧化还原蛋白质组型的计算分析揭示了新的见解 |
Cobley, J. N. |
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Computational Analysis of Human Cysteine Redox Proteoforms Reveals Novel Insights |
| 在ATP依赖性转位酶SMARCAL1、ZRANB3和HLTF的作用下，DNA复制叉反转过程中DNA损伤的链依赖性旁路机制 |
Adolph, M. B. |
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Strand dependent bypass of DNA lesions during fork reversal by ATP-dependent translocases SMARCAL1, ZRANB3, and HLTF |
| 高通量机器人分离人类iPS细胞克隆揭示了CRISPR-Cas9介导的相同遗传操作常导致同源纯合诱导 |
Takahashi, G. |
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High-throughput robotic isolation of human iPS cell clones reveals frequent homozygous induction of identical genetic manipulations by CRISPR-Cas9 |
| 高精度组装抛光与DeepPolisher |
Mastoras, M. |
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Highly accurate assembly polishing with DeepPolisher |
| 重新定义P环NTP酶早期进化中的功能连续性界限 |
Demkiv, A. O. |
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Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases |
| 红细胞内恶性疟原虫寄生虫消耗血红蛋白的噪音：起源及可能的影响 |
Perko, J. R. |
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Noisy hemoglobin consumption by erythrocytic Plasmodium falciparum parasites: origins and possible implications |
| 对两种锰氧化酶的种群水平控制扩展了细菌锰生物矿化的生态位 |
Gehin, G. |
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Population-level control of two manganese oxidases expands the niche for bacterial manganese biomineralization |
| 胶质细胞源性神经营养因子家族受体α样蛋白（GFRAL）的表达仅限于尾部脑干。 |
Hes, C. |
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GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem |
| 一种基于草甘膦的除草剂在保留淡水细菌浮游生物群落内物种多样性的同时，选择性地促进了遗传变异。 |
Derrick, E. |
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A glyphosate-based herbicide selects for genetic changes while retaining within-species diversity in a freshwater bacterioplankton community |
| 在果蝇细胞中使用整合和抗CRISPR（IntAC）技术进行的高分辨率全基因组CRISPR敲除筛选 |
Viswanatha, R. |
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Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) |
| 东非的“同一个健康”：产ESBL大肠杆菌的传播或独立抗菌素耐药基因在生态区间流动无障碍 |
Musicha, P. |
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One Health in Eastern Africa: No barriers for ESBL producing E. coli transmission or independent antimicrobial resistance gene flow across ecological compartments |
| 隐形荧光蛋白渲染：基因编码的4-氰色氨酸保留其结构并实现配体结合位点的检测 |
Qianzhu, H. |
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Rendering Proteins Fluorescent Inconspicuously: Genetically Encoded 4-Cyanotryptophan Conserves Their Structure and Enables the Detection of Ligand Binding Sites |
| 细胞内处理技术能够对低输入量的秀丽隐杆线虫进行快速且深入的蛋白质组分析。 |
Elsayyid, M. |
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In-cell processing enables rapid and in-depth proteome analysis of low-input Caenorhabditis elegans |