| 无监督机器学习揭示了HeLa细胞在细胞周期阻滞解除后基因表达的时间成分 |
Maimon, T. |
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N/A |
Unsupervised machine learning reveals temporal components of gene expression in HeLa cells following release from cell cycle arrest |
| SARS-CoV-2和HSV-1诱导人脑脊液中淀粉样蛋白聚集，导致可溶性蛋白质急剧减少。 |
Christ, W. |
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N/A |
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion |
| 冷适应性鲑科鱼类在世代内和跨世代环境变暖中的转录组响应 |
Penney, C. M. |
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N/A |
Transcriptomic responses to within- and transgenerational environmental warming in a cold-adapted salmonid |
| 通过交叉拟合加速基于R2的高维中介效应区间估计 |
Xu, Z. |
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N/A |
Speeding up interval estimation for R2-based mediation effect of high-dimensional mediators via cross-fitting |
| 活体中皮层下磁性物质的非指数横向弛豫衰减特性 |
Oliveira, R. |
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N/A |
In-vivo characterization of magnetic inclusions in the subcortex from non-exponential transverse relaxation decay |
| 肌动蛋白介导的细胞核形变调控多纤毛室管膜细胞的分化。 |
Basso, M. |
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N/A |
Actin-based deformations of the nucleus control multiciliated ependymal cell differentiation. |
| mbctools：一个用户友好的宏条形码分析和跨平台管道，用于分析多种生物的大量多样性扩增子测序数据。 |
Barnabe, C. |
PDF |
N/A |
mbctools: A User-Friendly Metabarcoding and Cross-Platform Pipeline for Analyzing Multiple Amplicon Sequencing Data across a Large Diversity of Organisms |
| 超低场儿科MRI在低收入和中等收入国家：使用多方向U-Net的超分辨率技术 |
Baljer, L. |
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N/A |
Ultra-low-field paediatric MRI in low- and middle-income countries: super-resolution using a multi-orientation U-Net |
| 丁香酚通过NRF2介导的氧化应激途径对1型糖尿病的保护作用 |
Jiang, Y. |
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N/A |
The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway |
| 基于免疫受体分析和多克隆应答细胞的单细胞RNA表达的TCR转基因克隆筛选 |
Debeuf, N. |
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N/A |
TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders |
| 星形胶质细胞在海马体-内嗅皮层突触中介导两种形式的峰时依赖性抑制。 |
Martinez-Gallego, I. |
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N/A |
Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses |
| 胎盘纳米颗粒介导的IGF1基因治疗在豚鼠模型中纠正了胎儿生长受限 |
Davenport, B. |
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N/A |
Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model |
| 目标学习而非反向传播解释了哺乳动物新皮层中的学习过程 |
Aceituno, P. V. |
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N/A |
Target Learning rather than Backpropagation Explains Learning in the Mammalian Neocortex |
| 氨基酸与葡萄糖发酵维持小鼠及人类恶性胶质瘤细胞的ATP含量 |
Lee, D. C. |
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N/A |
Amino Acid and Glucose Fermentation Maintain ATP Content in Mouse and Human Malignant Glioma Cells |
| 用于研究疟原虫主要毒力因子功能的一个系统 |
Cronshagen, J. |
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N/A |
A system for functional studies of the major virulence factor of malaria parasites |
| 线粒体输入蛋白TIMM50缺乏的生化和神经生理学效应 |
Paz, E. |
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N/A |
Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50 |
| 珊瑚宿主积极积累无机碳以维持与共生藻的共生关系 |
Zhang, B. |
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N/A |
Coral hosts actively accumulate inorganic carbon for Symbiodiniaceae to maintain symbiotic relationships |
| 丘脑皮层对分层认知控制的贡献 |
Chen, X. |
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N/A |
Thalamocortical contributions to hierarchical cognitive control |
| β-1,6-葡聚糖在双层真菌细胞壁的结构和重塑中起着核心作用。 |
Bekirian, C. |
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N/A |
Beta-1,6-glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall |
| 植物系统中的Mobius组装强调了基因调控中的启动子-编码序列-终止子相互作用 |
Kocaoglan, E. G. |
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N/A |
Mobius Assembly for Plant Systems highlights promoter-coding sequence terminator interaction in gene regulation |
| 参考基因组的纬度梯度 |
Linck, E. B. |
PDF |
N/A |
A latitudinal gradient of reference genomes |
| 通过折叠和稳定性的全面指南，揭示细胞色素c与疾病的关联 |
Yousaf, M. A. |
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N/A |
A comprehensive guide through the fold and stability of cytochrome c with implications for disease |
| 下颌关节假体在完整咀嚼周期中的生物力学评估 |
Ghosh, R. |
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N/A |
Biomechanical Evaluation of Temporomandibular Joint Implants Under Complete Mastication Cycle |
| 单倍型解析组装提供了对新疆最古老葡萄品种（木纳格）基因组组成的深入了解。 |
Zhong, H. |
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N/A |
Haplotype-resolved assemblies provide insights into genomic makeup of the oldest grapevine cultivar (Munage) in Xinjiang |
| 基于深度学习的基因扰动效应预测尚未超越简单的线性方法。 |
Ahlmann-Eltze, C. |
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N/A |
Deep learning-based predictions of gene perturbation effects do not yet outperform simple linear methods |
| 将全长FLT1表达重定向至其可溶性异构体可促进缺血后血管生成。 |
Bundalo, M. |
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N/A |
Redirecting full-length FLT1 expression towards its soluble isoform promotes postischemic angiogenesis |
| 定性脑电图异常表明大脑网络向抑制主导型转变。来自EU-AIMS LEAP研究的结果显示 |
Juarez-Martinez, E. L. |
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N/A |
Qualitative EEG abnormalities signal a shift towards inhibition-dominated brain networks. Results from the EU-AIMS LEAP studies |
| 通过个性化抗原无关筛选方法识别的T细胞受体靶向共享的新抗原KRAS Q61H |
Lennerz, V. |
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N/A |
T-cell receptors identified by a personalized antigen-agnostic screening approach target shared neoantigen KRAS Q61H |
| TBC1D24调控线粒体与内质网-线粒体接触位点 |
Benhammouda, S. |
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N/A |
TBC1D24 regulates mitochondria and endoplasmic reticulum-mitochondria contact sites |
| 在妊娠中期，母体血浆中apelin水平较低与重度、早发型胎儿生长受限的不良妊娠结局相关。 |
Braun, N. |
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N/A |
Low maternal plasma apelin in the second trimester is associated with adverse pregnancy outcome in severe, early-onset fetal growth restriction |
| 通过ERECTA的触发开关机制预防配体感知前后的不当信号传递 |
Chen, L. |
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N/A |
Preventing Inappropriate Signals Pre- and Post-Ligand Perception by a Toggle-Switch Mechanism of ERECTA |
| 主要镰刀菌物种在温度和水活性约束组合下的生理生态行为 |
Foulongne-Oriol, M. |
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N/A |
Ecophysiological Behaviour Of Major Fusarium Species In Response To Combinations Of Temperature And Water Activity Constraints |
| Sox9可防止视网膜退化，并在成年小鼠眼中对角膜缘干细胞的分化起着必要作用。 |
Hurtado, A. |
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N/A |
Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye |
| 亲缘关系密切的叶蝉亚科中微生物群落的显著差异：Typhlocybinae和Eurymelinae（叶蝉科，半翅目） |
Kobiałka, M. |
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N/A |
Extremely distinct microbial communities in closely related leafhopper subfamilies: Typhlocybinae and Eurymelinae (Cicadellidae, Hemiptera) |
| HuR对稳态B细胞信号转录后调控对于先天性B细胞的维持和功能是必需的。 |
Capitan-Sobrino, D. |
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N/A |
Post-transcriptional control of homeostatic B- cell signalling by HuR is required for innate B cell maintenance and function. |
| TIRTL-seq：深度、定量且经济实惠的配对TCR受体组测序 |
Pogorelyy, M. V. |
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N/A |
TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencing |
| 物种间生长特征的差异正在推动谷物-豆类间作产量：基于聚合数据集的统计学习方法 |
Mahmoud, R. |
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N/A |
Differences in growth features between species are driving cereal-legume intercrop yield: a statistical learning approach based on aggregated dataset |
| BirdNET在欧洲城市声学鸟类监测方面与专家一样出色。 |
Fairbairn, A. J. |
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N/A |
BirdNET is as good as experts for acoustic bird monitoring in a European city |
| 蒸气压亏缺主导了生态系统光合量子产量的时空变化。 |
Yu, L. |
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N/A |
Vapor pressure deficit dominates the spatiotemporal variations in ecosystem photosynthetic quantum yield |
| 伊利诺伊州西尼罗病毒传播媒介（库蚊和淡色库蚊）中广泛存在的杀虫剂抗性机制证据 |
Noel, K. |
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N/A |
Mechanistic evidence of widespread insecticide resistance among Illinois West Nile virus vectors (Culex pipiens and Culex restuans) |
| 灵长类动物（包括人类）大脑进化与手部灵巧性的协同演化 |
Baker, J. |
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N/A |
The coevolution of encephalization and manual dexterity in hominins and other primates |
| 纤毛虫细胞衰老的起源 |
Mitteldorf, J. |
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N/A |
Origin of Cellular Senescence in Ciliates |
| 基因组和表型预测在苹果育种中应用的评估 |
Jung, M. |
PDF |
N/A |
Evaluation of genomic and phenomic prediction for application in apple breeding |
| 通过解决合成环状RNA中的污染物来缓解细胞功能障碍 |
Zhang, Z. |
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N/A |
Mitigating Cellular Dysfunction by Addressing Contaminants in Synthetic circRNA |
| 胶质母细胞瘤对溶瘤HSV1反应的纵向分析指导PLX3397联合用药以增强病毒易感性 |
Ito, H. |
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N/A |
Longitudinal analysis of glioblastoma response to oncolytic HSV1 guides PLX3397 combination for enhanced viral permissiveness |
| MAASWERP研究：一项关于测量老年小鼠主动脉生物力学的国际比较案例研究 |
Neutel, C. H. G. |
PDF |
N/A |
The MAASWERP study: An international, comparative case study on measuring biomechanics of the aged murine aorta |
| 跨表达分析揭示了空间转录组学中协调基因表达的模式 |
Sarwar, A. |
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N/A |
Cross-expression analysis reveals patterns of coordinated gene expression in spatial transcriptomics |
| 通过使用扭曲分子的属性条件训练来提高3D分子生成的结构合理性 |
Vost, L. |
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N/A |
Improving Structural Plausibility in 3D Molecule Generation via Property-Conditioned Training with Distorted Molecules |
| 利用MELISSA模型进行安全评估的整合位点数据建模 |
Lin, T.-Y. |
PDF |
N/A |
Modeling integration site data for safety assessment with MELISSA |
| BrainSTEM：一种多分辨率胎儿脑图谱，用于评估人中脑培养的保真度 |
Toh, H. |
PDF |
N/A |
BrainSTEM: A multi-resolution fetal brain atlas to assess the fidelity of human midbrain cultures |
| 校准额外的计算工具扩展了ClinGen在PP3/BP4标准下对变异分类的推荐选项 |
Bergquist, T. |
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N/A |
Calibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteria |
| 整合多种实验信息以辅助GRASP进行蛋白质复合物结构预测 |
Xie, Y. |
PDF |
N/A |
Integrating various Experimental Information to Assist Protein Complex Structure Prediction by GRASP |
| 从多种RNA-DNA连接数据中检测统计学上稳健的相互作用 |
Zehr, S. |
PDF |
N/A |
Detection of statistically robust interactions from diverse RNA-DNA ligation data |
| Bolero：一种专门的工作流程，用于从结合5RACE扩增转录本的长读长测序方法中解析乙型肝炎病毒转录组 |
Grand, X. |
PDF |
N/A |
Bolero: a dedicated workflow to decipher Hepatitis B virus transcriptome from long-reads sequencing method coupled to 5RACE amplification of transcripts |
| 从DNA序列预测和功能解析染色体间基因组架构的TwinC方法 |
Jha, A. |
PDF |
N/A |
Prediction and functional interpretation of inter-chromosomal genome architecture from DNA sequence with TwinC |
| 肌纤维特异性FoxP1敲除可保护雄性小鼠免受胰腺癌引起的肌肉萎缩，但对雌性小鼠无效。 |
Schonk, M. M. |
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N/A |
Myofiber-specific FoxP1 knockout protects against pancreatic cancer-induced muscle wasting in male but not female mice. |
| 成纤维细胞调节人乳头瘤病毒阳性角质形成细胞的转化潜能 |
James, C. D. |
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N/A |
Fibroblasts Regulate the Transformation Potential of Human Papillomavirus-positive Keratinocytes |
| 视网膜神经节细胞对阿尔茨海默病中致病性tau的易感性 |
Davis, M. R. |
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N/A |
Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer's disease |
| 一种动力学筛选方法加速了靶向蛋白质降解剂的开发 |
Fan, A. T. |
PDF |
N/A |
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development |
| 选择性Rho激酶2抑制剂KD025在精神分裂症的遗传和药理学小鼠模型中表现出类似抗精神病药物的效果。 |
Tanaka, R. |
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N/A |
Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia |
| 不活动介导的分子适应：从一种新的临床前体力活动减少模型中获得的见解 |
Meyer, A. |
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N/A |
Inactivity-mediated molecular adaptations: insights from a novel pre-clinical model of physical activity reduction |
| 体外补充DHA可抑制人原代巨噬细胞中前列腺素E2的形成 |
Kirchhoff, R. |
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N/A |
Ex vivo DHA supplementation suppresses prostaglandin E2 formation in primary human macrophages |
| 银屑病血液和皮肤中免疫细胞的单细胞图谱 |
Deng, J. |
PDF |
N/A |
Single-cell Landscape of Immune Cells in Blood and Skin in Psoriasis |
| 听音乐在双眼竞争期间调节对绘画的视觉感知 |
Jiang, X. |
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N/A |
Listening to music modulates visual perception of paintings during binocular rivalry |
| 跨功能模块的生物衰老高维表征 |
Ying, K. |
PDF |
N/A |
High-dimensional Ageome Representations of Biological Aging across Functional Modules |
| 定量蛋白质组学揭示了M1和M2单核细胞来源的人类巨噬细胞外泌体货物的差异 |
Pantazi, P. |
PDF |
N/A |
Quantitative proteomics reveals differential extracellular vesicle cargo from M1 and M2 monocyte-derived human macrophages |
| 谷氨酰胺的可用性调节组织中树突状细胞亚群 |
Lobel, G. P. |
PDF |
N/A |
Glutamine availability regulates cDC subsets in tissue |
| CCR2限制了CD8 TRM细胞的炎症功能，这些功能在从WNV脑炎恢复期间损害了识别记忆 |
Ai, S. |
PDF |
N/A |
CCR2 limits inflammatory functions of CD8 TRM cells that impair recognition memory during recovery from WNV encephalitis |
| 通过性状-环境关系揭示的环境适应微生物策略 |
Ren, M. |
PDF |
N/A |
Microbial strategies of environmental adaptation revealed by trait-environmental relationships |
| 基于生理学的人口模型/非洲十三个入侵物种的GIS分析：为何生物学至关重要 |
Gutierrez, A. P. |
PDF |
N/A |
Physiologically based demographic model/GIS analyses of thirteen invasive species in Africa: why the biology matters |
| 纠缠进化模型：应用于自适应突变 |
Ross, P. |
PDF |
N/A |
Entangled Evolution Model: Application to Adaptive Mutation |
| 水蓼（Amaranthus tuberculatus）中性的进化、多样性和遗传结构 |
Kreiner, J. M. |
PDF |
N/A |
The evolution, diversity, and genetic architecture of sex in waterhemp (Amaranthus tuberculatus) |
| 个体间不同的重组景观是由多态的可移动元件驱动的。 |
Huang, Y. |
PDF |
N/A |
Varying recombination landscapes between individuals are driven by polymorphic transposable elements |
| 小鼠造血系统的克隆动态与体细胞演化 |
Kapadia, C. D. |
PDF |
N/A |
Clonal dynamics and somatic evolution of haematopoiesis in mouse |
| 禾谷镰刀菌假基因的鉴定与结构表征。 |
Rau, D. |
PDF |
N/A |
Identification and structural characterization of pseudogenes in Fusarium graminearum. |
| 利用多层单细胞组学技术表征人巨细胞病毒特异性CD8+ T细胞 |
Gemuend, I. |
PDF |
N/A |
Characterizing human CMV-specific CD8+ T cells using multi-layer single-cell omics |
| 具有触发阀的开敞式水渠系统中毛细流动的动力学特性 |
Tokihiro, J. C. |
PDF |
N/A |
The dynamics of capillary flow in an open-channel system featuring trigger valves |
| 一个新的用于估计同义替换选择作用的比较框架。 |
Verdonk, H. |
PDF |
N/A |
A new comparative framework for estimating selection on synonymous substitutions. |
| 超越关联性：疾病致病基因因果关系抽取基准数据集（CRED）、其比较评估、解读与应用 |
Bansal, N. |
PDF |
N/A |
Beyond associations: A benchmark Causal Relation Extraction Dataset (CRED) of disease-causing genes, its comparative evaluation, interpretation and application |
| 早期肺癌肿瘤微环境中存在的Tenascin-C通过整合素激活和FAK促进肿瘤进展。 |
Mendoza, M. C. |
PDF |
N/A |
Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin activation and FAK |
| 大麻二酚（CBD）对人胶质母细胞瘤细胞核心区和浸润边界区的差异性抗增殖作用 |
Abassi-Rana, G. |
PDF |
N/A |
DIFFERENTIAL ANTIPROLIFERATIVE EFFECTS OF CANNABIDIOL (CBD) IN THE CORE AND INFILTRATIVE BOUNDARY OF HUMAN GLIOBLASTOMA CELLS |
| CDK4失活平衡了三阴性乳腺癌细胞对凋亡的抵抗与代谢敏感性的增强 |
Ziegler, D. V. |
PDF |
N/A |
CDK4 inactivation balances resistance to apoptosis with heightened metabolic sensitivity in triple negative breast cancer cells |
| 截短的补体因子H Y402基因疗法治愈C3肾小球肾炎 |
Chew, L. A. |
PDF |
N/A |
Truncated Complement Factor H Y402 Gene Therapy Cures C3 Glomerulonephritis |
| 室温气溶胶脱水绿色荧光蛋白 |
Pan, Z. |
PDF |
N/A |
Room Temperature Aerosol Dehydration of Green Fluorescence Protein |
| 代谢组学和转录组学分析的整合揭示了ChREBP转录因子在能量代谢中的新调控功能 |
An, J. |
PDF |
N/A |
Integration of metabolomic and transcriptomic analyses reveals novel regulatory functions of the ChREBP transcription factor in energy metabolism |
| GCK-MODY中独特的持续时间与饮食依赖性脂质谱及肾脏并发症 |
Huang, Y. |
PDF |
N/A |
Distinct duration and diet dependent lipid profiles and renal complicationsin GCK-MODY |
| 牛淋巴和非淋巴组织中的树突状细胞亚群：正在进行的工作 |
Talker, S. C. |
PDF |
N/A |
Bovine dendritic-cell subsets in lymphoid and non-lymphoid tissues: work in progress |
| 一种人类同源的SIR2抗病毒蛋白通过TLR途径介导免疫 |
Bonhomme, D. |
PDF |
N/A |
A human homolog of SIR2 antiphage proteins mediates immunity via the TLR pathway |
| 一种用于重建性社会学习演化的神经网络模型 |
Chisausky, J. |
PDF |
N/A |
A neural network model for the evolution of reconstructive social learning |
| 优化冷冻保存遗传资源在动物种群选择和保护中的应用 |
Jacques, A. |
PDF |
N/A |
Optimizing the use of cryopreserved genetic resources for the selection and conservation of animal populations |
| 使用自回归生成模型重建祖先蛋白质序列 |
De Leonardis, M. |
PDF |
N/A |
Reconstruction of ancestral protein sequences using autoregressive generative models |
| 推进对抗胶质母细胞瘤的临床反应：评估SHP1705 CRY2激活剂在临床前模型中的疗效及在I期试验中的安全性 |
Chan, P. |
PDF |
N/A |
Advancing Clinical Response Against Glioblastoma: Evaluating SHP1705 CRY2 Activator Efficacy in Preclinical Models and Safety in Phase I Trials |
| 苯甲酸钠通过SKN-1/Nrf2信号通路促进脂肪积累和衰老：来自秀丽隐杆线虫模型的证据 |
Lee, J. D. |
PDF |
N/A |
Sodium Benzoate Promotes Fat Accumulation and Aging via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model |
| 比较多系统萎缩与帕金森病中的α-突触核蛋白相互作用组，揭示了独特的和共有的病理特征。 |
Killinger, B. A. |
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Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinsons disease reveals unique and shared pathological features. |
| 用于从多通道音频中定位啮齿动物发声的Vocal Call Locator基准（VCL） |
Peterson, R. E. |
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Vocal Call Locator Benchmark (VCL) for localizing rodent vocalizations from multi-channel audio |
| 来自精神分裂症个体的hiPSC衍生星形胶质细胞促进类似小胶质细胞的吞噬作用和趋化性改变 |
Cardozo, P. L. |
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hiPSC-derived astrocytes from individuals with schizophrenia promote alterations in phagocytosis and chemotaxis of microglial-like cells |
| 下肢指向评估不完全脊髓损伤后节段间动力学及其与本体感觉障碍的关联作用。 |
Malik, R. N. |
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Lower limb pointing to assess intersegmental dynamics after incomplete spinal cord injury and the associated role of proprioceptive impairments. |
| 在青蛙变态发育过程中，脊髓神经元的多样性随着从游泳到四肢运动的转变呈指数级增长。 |
Vijatovic, D. |
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Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis |
| 在情绪面孔匹配任务中并发的大规模脑动态及其与行为和心理健康的关系 |
Korponay, C. |
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Concurrent large-scale brain dynamics during the emotional face matching task and their relation to behavior and mental health |
| 人类内侧丘脑枕核参与面部和触觉处理，并根据当前的刺激动态调整其皮质连接性。 |
Gaudet, M. |
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Human medial pulvinar is involved in face and tactile processing and dynamically adjusts its cortical connectivity based on ongoing stimulation |
| 在声学听力听者和耳蜗植入使用者中，高呈现声级下听觉努力增加和言语辨别能力下降 |
Huang, C. G. |
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Increased listening effort and decreased speech discrimination at high presentation sound levels in acoustic hearing listeners and cochlear implant users |
| 脂联素在母体肥胖暴露的成年后代中，恢复了阻力血管的胆碱能舒张作用。 |
Murphy, M. |
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Adiponectin restores cholinergic vasodilation in resistance vessels from adult offspring exposed to maternal obesity in utero |
| 终身健身优势：繁殖地忠诚度和近亲繁殖成本低，使得一种鸟类合作繁殖者能够容忍近亲繁殖。 |
Shah, S. |
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Lifetime fitness benefits of breeding site fidelity and low costs of inbreeding permit inbreeding tolerance in an avian cooperative breeder |
| 纹状体和海马中奖励的情感和信息成分的差异表征 |
Shen, X. |
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Differential representations for affective and informative components of reward in the striatum and hippocampus |
| 前扣带回前额叶皮层中的组蛋白去乙酰化酶5限制与情境相关的可卡因寻求行为 |
Barry, S. M. |
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Histone deacetylase 5 in prelimbic prefrontal cortex limits context-associated cocaine seeking |
| 乙酰胆碱在不确定性下的强化学习和决策中的作用 |
Kurtenbach, H. |
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A role for acetylcholine in reinforcement learning and decision making under uncertainty |
| 一项大规模队列研究（n = 591）探讨了丘脑间粘连的存在与否对认知、神经影像学和遗传结果的影响。 |
Vidal, J. P. |
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A large cohort study (n = 591) on the impact of the presence or absence of the interthalamic adhesion: cognitive, neuroimaging, and genetic results |
| 可卡因自我戒断促进了小胶质细胞对星形胶质细胞的修剪，从而推动了可卡因的觅药行为。 |
Testen, A. |
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Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior |
| 刺激椭圆囊不规则纤维会在前庭核复合体（VNC）中产生从前到后的活动梯度，但不会在前庭小脑（VeCb）中产生。 |
Holt, A. G. |
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Stimulation of otolith irregular fibers produces a rostro-caudal gradient in activity in the vestibular nuclear complex (VNC), but not the vestibulocerebellum (VeCb) |
| SETα和SETβ在早期细胞命运决定中具有不同的作用 |
Lim, P. S. L. |
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Distinct Roles for SETα and SETβ in Early Cell Fate Decisions |
| 传粉者Eristalis tenax中固有花卉偏好的消失 |
Mishra, A. |
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Extinction of innate floral preferences in the pollinator Eristalis tenax |
| 椎间盘髓核细胞网络建模 |
Tseranidou, S. |
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Nucleus Pulposus Cell Network Modelling in the Intervertebral Disc |
| 统一大模型：一种全新整体建模范式，用于在完整和谐的尺度上研究生物系统 |
Aucello, R. |
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UnifiedGreatMod: A New Holistic Modeling Paradigm for Studying Biological Systems on a Complete and Harmonious Scale |
| 单细胞网络方法解析妇科及乳腺癌中的代谢调控 |
Srivastava, A. |
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A Single-Cell Network Approach to Decode Metabolic Regulation in Gynecologic and Breast Cancers |
| 小胶质细胞决定免疫挑战环境，并促进布洛芬在人视网膜类器官中的作用。 |
Schmied, V. |
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Microglia determine an immune-challenged environment and facilitate ibuprofen action in human retinal organoids. |
| 疱疹病毒膜融合激活的变构机制 |
Gonzalez-Del Pino, G. L. |
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Allosteric mechanism of membrane fusion activation in a herpesvirus |
| 通过Sideroxydans lithotrophicus ES-1中的MtoAB孔蛋白-多血红素细胞色素复合物进行的微生物磁铁矿氧化 |
Keffer, J. L. |
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Microbial magnetite oxidation via MtoAB porin-multiheme cytochrome complex in Sideroxydans lithotrophicus ES-1 |
| 大肠杆菌中rRNA操纵子的聚集被σH破坏。 |
Ho, K. |
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Clustering of rRNA operons in E. coli is disrupted by σH |
| 生牛奶中甲型H5N1流感病毒的热灭活谱 |
Nooruzzaman, M. |
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Thermal inactivation spectrum of influenza A H5N1 virus in raw milk |
| 巨型转座子推动了热厌氧杆菌（Thermoanaerobacter kivui）对一氧化碳的适应 |
Hocq, R. |
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A megatransposon drives the adaptation of Thermoanaerobacter kivui to carbon monoxide |
| 在受限条件下细菌的生长需要转录适应以抵抗代谢物引起的膨压增加 |
Le Blanc, L. |
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Bacterial growth under confinement requires transcriptional adaptation to resist metabolite-induced turgor pressure build-up |
| 一种隐秘的噬菌体转录因子通过宿主基因调控驱动表型变化 |
Lally, P. |
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A Cryptic Prophage Transcription Factor Drives Phenotypic Changes via Host Gene Regulation |
| 饮食诱导的Rad51c突变小鼠线粒体DNA复制不稳定性驱动炎症性贫血的性别偏向 |
Tomaszowski, K.-H. |
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Diet induced mitochondrial DNA replication instability in Rad51c mutant mice drives sex-bias in anemia of inflammation |
| 神经化样蛋白差异性激活Notch配体 |
Airich, A. |
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Neuralized-like proteins differentially activate Notch ligands |
| 一个依赖于气候和人口的扩散模型预测了白纹伊蚊在欧洲的传播情况。 |
Barman, S. |
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A climate and population dependent diffusion model forecasts the spread of Aedes Albopictus mosquitoes in Europe |
| 使用SomaScan和Olink检测方法进行蛋白质丰度定量时，体外溶血和反复冻融循环的影响 |
Candia, J. |
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Effects of in vitro hemolysis and repeated freeze-thaw cycles in protein abundance quantification using the SomaScan and Olink assays |
| 藻胆蛋白使海洋硅藻表现出社会行为 |
Font-Munoz, J. S. |
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Phytochromes Enable Social Behavior in Marine Diatoms |
| 保守非编码元件的剧烈进化变化伴随着Caenorhabditis inopinata的非凡特征 |
Tamagawa, K. |
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Dramatic evolutionary changes of conserved noncoding elements accompanied by extraordinary features of Caenorhabditis inopinata |
| 揭示氨基糖苷类药物与假尿苷在IRES翻译中的分子相互作用 |
Zhao, Y. |
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Unveil the Molecular Interplay between Aminoglycosides and Pseudouridine in IRES Translation |
| ERAP1活性不仅调节免疫肽组，还影响癌细胞的蛋白质组、代谢和应激反应。 |
Nikopaschou, M. |
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ERAP1 activity modulates the immunopeptidome but also affects the proteome, metabolism and stress responses in cancer cells |
| 特定C2H2锌指结构域中的构象动力学使锌响应基因抑制在S. pombe中得以实现 |
Wadhwa, V. |
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Conformational dynamics in specialized C2H2 zinc finger domains enable zinc-responsive gene repression in S. pombe |
| Rubisco包装及天然β-羧酶体的化学计量组成 |
Sun, Y. |
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Rubisco packaging and stoichiometric composition of a native β-carboxysome |
| 从头设计的别构可调蛋白纤维的成核限制组装和极性生长 |
Shen, H. |
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Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament |
| AlphaFold2和AlphaFold3在人类与寄生虫相互作用预测中导致显著不同的结果 |
Ozden, B. |
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AlphaFold2 and AlphaFold3 leads to significantly different results in human-parasite interaction prediction |
| 基因组中的基序分布提供了关于基因簇集和协同调控的见解。 |
Chakraborty, A. |
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Motif distribution in genomes gives insights into gene clustering and co-regulation |
| BioPAX-Explorer：一个面向对象的Python框架，用于克服查询生物网络的复杂性 |
Moreews, F. |
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BioPAX-Explorer: a Python Object-Oriented framework for overcoming the complexity of querying biological networks |
| 一种环状多肽通过结合异常暴露的SNAP25靶向胶质母细胞瘤 |
Arias, A. G. |
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A CYCLIC PEPTIDE TARGETS GLIOBLASTOMA BY BINDING TO ABERRANTLY EXPOSED SNAP25 |
| 利什曼原虫墨西哥亚种中N-乙酰转移酶10（NAT10）的功能表征 |
Rodrigues Maran, S. |
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Functional characterization of N-acetyltransferase 10 (NAT10) in Leishmania mexicana |
| 水生哺乳动物中普遍存在的选择放松 |
Farina, B. M. |
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Widespread selection relaxation in aquatic mammals |
| 胚胎干细胞中TF-DNA识别的双峰特异性 |
Povolotskii, M. |
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Bimodal Specificity of TF-DNA Recognition in Embryonic Stem Cells |
| 通过嵌合eCLIP方法在RNA结合蛋白依赖的方式下映射snoRNA与目标RNA的相互作用 |
Song, Z. |
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Mapping snoRNA-target RNA interactions in an RNA binding protein-dependent manner with chimeric eCLIP |