| 传导机制在冷温度下对不同外周器官的鼠三叉神经和迷走神经节神经元的影响 |
Gers-Barlag, K. |
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N/A |
Transduction mechanisms for cold temperature in mouse trigeminal and vagal ganglion neurons innervating different peripheral organs |
| 从组学数据集中数据驱动的提取人类激酶-底物关系 |
Maier, B. D. |
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N/A |
Data-driven extraction of human kinase-substrate relationships from omics datasets |
| 利用合成聚合物探究脂质力机制 |
Jacobs, M. L. |
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N/A |
Probing the force-from-lipid mechanism with synthetic polymers |
| 自我信念的力量：成长型思维通过中皮层功能共激活和动态重构促进认知发展 |
Zhao, Y. |
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N/A |
Power of self-belief: Growth mindset fosters cognitive development via mesocortical functional coactivation and dynamic reconfiguration |
| 多巴胺神经元在果蝇嗅觉记忆中具有不同的、急性的功能，驱动吸引和厌恶 |
Mohammad, F. |
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N/A |
Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion |
| 有齿鲸基因的分子进化揭示了在不同环境中回声定位的适应性 |
Magpali, L. |
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N/A |
Molecular evolution of toothed whale genes reveals adaptations to echolocating in different environments |
| 植物乳杆菌和八角提取物抑制单纯疱疹病毒和水疱性口炎病毒增殖与诱导MX基因表达相关 |
Elebeedy, D. |
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N/A |
Inhibition of Herpes simplex virus and Vesicular stomatitis virus Proliferation by Lactiplantibacillus planterum and star anise Extract Is Associated with Induction of MX gene expression |
| Spanve：一种用于在大规模空间转录组数据中检测下游友好型空间变异基因的统计方法 |
Cai, G. |
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N/A |
Spanve: A Statistical Method for Detecting Downstream-Friendly Spatially Variable Genes in Large-Scale Spatial Transcriptomic Data |
| 自噬体膜连接的重构揭示了Atg11结合膜的能力对线粒体自噬的重要性。 |
Andhare, D. |
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Reconstitution of autophagosomal membrane tethering reveals that the ability of Atg11 to bind membranes is important for mitophagy. |
| 所有CDKN2A错义变体的功能表征及其与致病性计算机模型的比较 |
Kimura, H. |
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Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity |
| 使用Neuropixels探针在猕猴初级视觉皮层中进行高分辨率层级识别 |
Zhang, L. A. |
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N/A |
High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes |
| 加压素1a受体拮抗剂破坏了大嘴乌鸦通过三重共居形成的雄性间亲和关系 |
Seguchi, A. |
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N/A |
Vasopressin 1a receptor antagonist disrupts male-male affiliative relationships formed by triadic cohabitation in large-billed crows |
| 磁共振经济学：在全脑关联研究中平衡样本量与扫描时长 |
Ooi, L. Q. R. |
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N/A |
MRI economics: Balancing sample size and scan duration in brain wide association studies |
| 线粒体呼吸图谱揭示了线粒体功能在性别和年龄上的差异变化 |
Sarver, D. C. |
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N/A |
Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age |
| 内源性过氧化氢正向调节肠道衍生肽的分泌，在秀丽隐杆线虫的氧化应激反应中增强神经内分泌作用 |
Jia, Q. |
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N/A |
Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in C. elegans |
| 使用单细胞转录组学对细胞周期状态和类似静止的G0状态进行分类 |
O'Connor, S. A. |
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N/A |
Classifying cell cycle states and a quiescent-like G0 state using single-cell transcriptomics |
| 空间转录组学在骨力学生物学中的应用：探索空间组学时代骨折愈合的力学调控。 |
Mathavan, N. |
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N/A |
Spatial Transcriptomics in Bone Mechanomics: Exploring the Mechanoregulation of Fracture Healing in the Era of Spatial Omics. |
| 人类侧隔核神经元的转录组特征分析揭示了跨物种保守和分化的标记基因 |
Phillips, R. A. |
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N/A |
Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species |
| 将代谢建模与成像结合用于筛选结直肠癌的治疗靶点 |
Tavakoli, N. |
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N/A |
Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer |
| 系统性遗传表征人类PKR激酶结构域突显其功能可塑性，以逃避痘病毒底物模拟 |
Chambers, M. J. |
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N/A |
Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic |
| 由于Vsx2位点上的LacZ敲入/敲出等位基因，导致小眼症和视网膜发育紊乱 |
Napoli, F. R. |
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N/A |
Microphthalmia and disrupted retinal development due to a LacZ knock-in/knock-out allele at the Vsx2 locus |
| 去卷积化的甲基化图谱可区分密切相关的黑色素细胞痣 |
Aldea, D. |
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N/A |
Deconvoluted methylation profiles discriminate between closely related melanocytic nevi |
| 植物交配系统的进化动力学：研究“有趣”植物繁殖系统的偏见可能会适得其反 |
Meyer, E. M. |
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N/A |
The evolutionary dynamics of plant mating systems: how bias for studying 'interesting' plant reproductive systems could backfire |
| 人类尿液微生物群的短期和中期时间变异性：一项观察性队列研究 |
Tlaskal, V. |
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N/A |
Short- and mid-term temporal variability of the human urinary microbiota: an observational cohort study |
| 通过超结构扩展显微镜技术，绘制犬视网膜感光细胞纤毛和杯状突起的蛋白质分布图 |
Takahashi, K. |
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N/A |
Mapping protein distribution in the canine photoreceptor sensory cilium and calyceal processes by ultrastructure expansion microscopy |
| VirID：超越病毒发现——综合平台助力全面RNA病毒特征研究 |
Yang, Z. |
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N/A |
VirID: Beyond Virus Discovery - An Integrated Platform for Comprehensive RNA Virus Characterization |
| cGAS-STING通路在急性缺血诱导的骨髓中性粒细胞生成和中性粒细胞激活中起关键作用 |
Zhu, J. |
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The cGAS-STING Pathway Is Essential in Acute Ischemia-Induced Neutropoiesis and Neutrophil Priming in the Bone Marrow |
| 通过巨胞饮作用减少顶端大小可缓解组织拥挤 |
Bresteau, E. |
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N/A |
Apical Size Reduction by Macropinocytosis Alleviates Tissue Crowding |
| 生长率驱动的建模揭示了表型适应如何驱动BRAFV600E突变型黑色素瘤的药物抗性 |
Hamis, S. |
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Growth rate-driven modelling reveals how phenotypic adaptation drives drug resistance in BRAFV600E-mutant melanoma |
| 由RhoA特异性GEF ARHGEF17介导的反馈调节调控肌动肌球蛋白网络的解聚 |
Rao, V. |
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Feedback regulation by the RhoA-specific GEF ARHGEF17 regulates actomyosin network disassembly |
| 微生物种群几乎从未按逻辑增长，也从未按次线性增长。 |
Camacho-Mateu, J. |
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N/A |
Microbial populations hardly ever grow logistically and never sublinearly |
| 将条形码测序技术应用于提高恶性疟原虫遗传筛选的通量和复杂性 |
Muhwezi, A. |
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N/A |
Application of barcode sequencing to increase the throughput and complexity of Plasmodium falciparum genetic screening |
| 通过血管壁龛的神经内分泌调控果蝇肠道再生。 |
Medina, A. |
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N/A |
Neuroendocrine Control of Intestinal Regeneration Through the Vascular Niche in Drosophila. |
| 通过SpaHDmap对空间转录组数据进行可解释的高分辨率降维 |
Tang, J. |
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N/A |
Interpretable high-resolution dimension reduction of spatial transcriptomics data by SpaHDmap |
| 针对癌症相关糖基化进行胃肠道和妇科癌症的过继T细胞治疗 |
Zingg, A. |
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N/A |
Targeting cancer-associated glycosylation for adoptive T cell therapy of gastro-intestinal and gynecological cancers |
| 利用活体叶片切片成像技术分析C4植物叶肉细胞中依赖于束鞘细胞的叶绿体运动 |
Kato, Y. |
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N/A |
Bundle sheath cell-dependent chloroplast movement in mesophyll cells of C4 plants analyzed using live leaf-section imaging |
| 使用质粒分析服务进行高效且成本效益高的长读长扩增子测序：应用于日本牵牛花中的转座子插入等位基因 |
Nakagawa, S. |
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N/A |
Labor- and cost-effective long-read amplicon sequencing using a plasmid analysis service: Application to transposon-inserted alleles in Japanese morning glory |
| 聚焦镓离子束的生物体积电子显微镜依赖于在断面形成辐射抗性富镓层。 |
Yang, Z. |
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N/A |
Biological volume EM with focused Ga ion beam depends on formation of radiation-resistant Ga-rich layer at block face |
| BrainUnit：将物理单位融入高性能AI驱动的科学计算 |
Wang, C. |
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N/A |
BrainUnit: Integrating Physical Units into High-Performance AI-Driven Scientific Computing |
| 出生后前六个月大脑网络的空间发展 |
Seraji, M. |
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N/A |
Spatial Development of Brain Networks During The First Six Postnatal Months |
| 白腿虾养殖生产力的微生物组决定因素 |
Shan, X. |
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N/A |
Microbiome determinants of productivity in whiteleg shrimp aquaculture |
| 授粉者Eristalis tenax中固有花卉偏好的消失 |
Rajan, D. H. |
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N/A |
Extinction of innate floral preferences in the pollinator Eristalis tenax |
| 从头设计的别构可调蛋白纤维的成核限制组装与极性生长 |
Shen, H. |
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N/A |
Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament |
| 使用神经网络解决巴布亚新几内亚人口的“走出非洲”事件 |
Mondal, M. |
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N/A |
Resolving out of Africa event for Papua New Guinean population using neural network |
| 高风险神经精神性拷贝数变异与人类脑细胞中趋同的转录组变化相关 |
Dugan, G. |
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N/A |
High-risk neuropsychiatric copy number variants are associated with convergent transcriptomic changes in human brain cells |
| miR-92a目标RBFOX2的过早上调劫持了PTBP剪接并损害了皮层神经元的分化。 |
Weissbach, S. |
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N/A |
Premature upregulation of miR-92a's target RBFOX2 hijacks PTBP splicing and impairs cortical neuronal differentiation. |
| 从一百万个单倍体基因组中估算人口统计学和突变率 |
Schraiber, J. G. |
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N/A |
Estimation of demography and mutation rates from one million haploid genomes |
| 在恒定条件下实验室小鼠发情周期的季节性变化 |
Reichard, T. M. |
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N/A |
Seasonality of the estrus cycle in laboratory mice under constant conditions |
| 在编码稀疏基因组的物种中，使用两步法从群体基因组数据推断人口统计和选择历史：以人类数据为例的应用 |
Soni, V. |
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N/A |
Inferring demographic and selective histories from population genomic data using a two-step approach in species with coding-sparse genomes: an application to human data |
| 第15组苗前除草剂对除草剂抗性和非抗性黑麦草的生长、表皮蜡质成分及脂肪酸代谢产生不同影响 |
Blyth, H. R. |
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N/A |
Group 15 Pre-emergent Herbicides Differentially Effect Plant Growth, Cuticular Wax Composition, and Fatty Acid Metabolism in Herbicide-Resistant and Herbicide-naïve Blackgrass |
| 调节β-连环蛋白对促进巨噬细胞中WNT表达和减轻肠道损伤具有重要意义。 |
Chugh, R. M. |
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N/A |
Modulation of β-Catenin is important to promote WNT expression in macrophages and mitigate intestinal injury |
| 表观遗传调控网络的扩展和多样化奠定了陆地植物进化过程中重大转变的基础 |
Petroll, R. |
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N/A |
The expansion and diversification of epigenetic regulatory networks underpins major transitions in the evolution of land plants |
| 广谱反应性抗VHH抗体用于表征、阻断或激活基于纳米抗体的CAR-T细胞 |
McComb, S. |
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N/A |
Broadly Reactive Anti-VHH Antibodies for Characterizing, Blocking, or Activating Nanobody-Based CAR-T Cells |
| 自然杀伤细胞功能在妊娠和肿瘤进展过程中受TGF-β信号通路的调控。 |
Yalin, A. |
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N/A |
Natural killer cell function is regulated by TGF-β signaling in pregnancy and tumor progression |
| TSTA：基于线程和SIMD的梯形成对/多序列比对方法 |
Peiyu, Z. |
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N/A |
TSTA: Thread and SIMD-Based Trapezoidal Pairwise/Multiple Sequence Alignment Method |
| 乳腺癌细胞系中非组蛋白赖氨酸甲基化位点及赖氨酸去甲基化酶的定量分析 |
Berryhill, C. A. |
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N/A |
Quantitative analysis of non-histone lysine methylation sites and lysine demethylases in breast cancer cell lines |
| 单核细胞衍生的细胞而非小胶质细胞在神经炎症中引起氧化组织损伤 |
Villar-Vesga, J. |
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N/A |
Monocyte-derived cells but not Microglia cause Oxidative Tissue Damage in Neuroinflammation |
| 发育期和成年期饮食的加性和情境依赖性效应及其在杂交果蝇群体中对生活史特征及其关联的影响 |
Chandrakanth, M. |
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N/A |
Additive and context-dependent effects of developmental and adult diet on life-history traits and their associations in outbred Drosophila melanogaster population |
| 用于研究药物载体和细菌通过活体黏膜屏障传输的人体中流体肠道模型 |
Wang, C.-M. |
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N/A |
Human Mesofluidic Intestinal Model for Studying Transport of Drug Carriers and Bacteria Through a Live Mucosal Barrier |
| 可及的染色质区域和DNA甲基化调控基因表达，导致芸苔属异源三倍体杂种的农艺性状发生变化 |
Cheng, D. |
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N/A |
Accessible chromatin regions and DNA methylation regulate gene expression leading to changes in agronomic traits in Brassica allotriploid hybrids |
| 聚合溶酶体靶向嵌合体：无需共用溶酶体靶向受体的胞外靶向蛋白降解 |
Lu, R. H.-H. |
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N/A |
Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting Receptors |
| 在常染色体隐性多囊肾病中，升高Gli3的逆转并未改变囊肿的形成。 |
Russell, L. G. |
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N/A |
Reversal of elevated Gli3 in Autosomal Recessive Polycystic Kidney Disease does not alter cystogenesis |
| 与摄食、先天免疫和行为调节相关的扁形动物分泌细胞类型 |
Mayorova, T. D. |
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N/A |
Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior |
| 微妙平衡的导航：点突变作弊病毒破坏病毒复制周期 |
Meir, M. |
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N/A |
Navigating a fine balance: point-mutant cheater viruses disrupt the viral replication cycle |
| Tbx4缺失影响出生后肺发育并易导致肺动脉高压。 |
Maldonado-Velez, G. |
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N/A |
Loss of Tbx4 Affects Postnatal Lung Development and Predisposes to Pulmonary Hypertension. |
| MutLgamma 在拟南芥中强制执行减数分裂交叉。 |
Durand, S. |
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N/A |
MutLgamma enforces meiotic crossovers in Arabidopsis thaliana |
| 开发并广泛测序了一个广泛认可的“瓶中基因组”匹配的肿瘤-正常配对样本，用于体细胞基准测试。 |
McDaniel, J. H. |
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N/A |
Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair for somatic benchmarks |
| 叉头框F1在肺动脉高压病理生物学中的作用 |
Gomez-Arroyo, J. |
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N/A |
Role of Forkhead box F1 in the Pathobiology of Pulmonary Arterial Hypertension |
| 开发一种小分子表观遗传再生疗法。通过皮下注射含有高剂量塞布他汀和视黄酸的海藻酸盐制剂，可促进组织生长、血管化和神经支配，并诱导广泛的表观遗传重编程。 |
Slonimska, P. |
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N/A |
Development of a small-molecule epigenetic regenerative therapy. Subcutaneous administration of alginate formulations with high loads of zebularine and retinoic acid promotes tissue growth, vascularization and innervation and induces extensive epigenetic repatterning |
| 统一表型本体（uPheno）：一个跨物种整合表型学的框架 |
Matentzoglu, N. |
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N/A |
The Unified Phenotype Ontology (uPheno): A framework for cross-species integrative phenomics |
| 局部方法计算蛋白质构象中立体化学的影响 |
da Rocha, W. |
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N/A |
Influence of stereochemistry in a local approach for calculating protein conformations |
| 卤化胆固醇改变了三元脂质膜的相行为 |
Mehta, D. |
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N/A |
Halogenated cholesterol alters the phase behavior of ternary lipid membranes |
| 研究新型血液处理方法以增强非小细胞肺癌生物标志物的鉴定 |
Karsten, E. |
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N/A |
Investigating the use of novel blood processing methods to boost the identification of biomarkers of non-small cell lung cancer |
| Gli2 过表达改变了去分化脂肪肉瘤细胞的分化状态，并在原位肿瘤中导致免疫抑制性髓系表型 |
Bennett, N. E. |
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N/A |
Gli2 Overexpression Alters the Differentiation Status of Dedifferentiated Liposarcoma Cells and Results in an Immunosuppressive Myeloid Phenotype in Orthotopic Tumors |
| SMARCB1的丧失在上皮样肉瘤中引发可靶向的表观遗传脆弱性 |
Jin, J. X. |
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N/A |
Loss of SMARCB1 evokes targetable epigenetic vulnerabilities in Epithelioid Sarcoma |
| 药理学SOS1抑制剂BI-3406在体内显示出与KRAS突变肿瘤中SOS1基因敲除相当的抗肿瘤活性。 |
BALTANAS, F. C. |
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N/A |
Pharmacological SOS1 inhibitor BI-3406 demonstrates in vivo anti-tumor activity comparable to SOS1 genetic ablation in KRAS mutant tumors |
| 独立推导预测药物诱发尖端扭转型室性心动过速的心律失常轴 |
Heitmann, S. |
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N/A |
Independent derivations of the axis of arrhythmia for predicting drug-induced torsades de pointes |
| 增加cGMP可改善微血管运动训练的适应性，与内皮一氧化氮合酶无关。 |
Winn, N. C. |
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N/A |
Increased cGMP improves microvascular exercise training adaptations independent of endothelial nitric oxide synthase |
| 急性簇细胞缺失导致小肠吸收不良及分泌细胞和免疫细胞谱系的改变 |
Momoh, M. |
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N/A |
Acute tuft cell ablation induces malabsorption and alterations in secretory and immune cell lineages in small intestine |
| 隔离生长激素对寿命和代谢的直接影响 |
Lasher, A. T. |
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N/A |
Isolating the Direct Effects of Growth Hormone on Lifespan and Metabolism |
| 数据独立采集质谱法作为元蛋白质组学的工具：使用模型微生物组进行实验室间比较 |
Rajczewski, A. T. |
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N/A |
Data-Independent Acquisition Mass Spectrometry as a Tool for Metaproteomics: Interlaboratory Comparison Using a Model Microbiome |
| SMoRe GloS：一种高效且灵活的框架，用于推断基于代理模型参数的全局敏感性 |
Bergman, D. R. |
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N/A |
SMoRe GloS: An efficient and flexible framework for inferring global sensitivity of agent-based model parameters |
| 基于机器学习的空间代谢谱预测揭示了形态学对星形胶质细胞能量代谢的影响 |
Papavasileiou, P. |
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N/A |
Machine Learning-based Predictions of Spatial Metabolic Profiles Demonstrate the Impact of Morphology on Astrocytic Energy Metabolism |
| 肽-MHC靶向的逆转录病毒能够实现肿瘤特异性T细胞的体内扩增及基因传递。 |
Xu, E. J. |
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N/A |
Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells |
| BCR连接特异性地抑制IgE类别转换重组 |
Wade-Vallance, A. K. |
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N/A |
BCR ligation selectively inhibits IgE class switch recombination |
| 克服突变KRAS表位翻译后修饰引起的免疫逃逸，实现TCR工程化T细胞介导的抗肿瘤活性 |
Lee, J. W. |
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N/A |
Overcoming immune evasion from post-translational modification of a mutant KRAS epitope to achieve TCR-engineered T cell-mediated antitumor activity |
| 凝聚素介导的染色质重塑调控传统树突状细胞的分化和功能 |
Adams, N. M. |
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N/A |
Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells |
| 基于SATAY的化学基因组筛选揭示了抗真菌抗性机制及ATI-2307和壳聚糖敏感性的关键决定因素 |
Karadzas, M. T. |
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N/A |
SATAY-Based Chemogenomic Screening uncovers Antifungal Resistance Mechanisms and Key Determinants of ATI-2307 and Chitosan Sensitivity |
| 沙漠生态区中暗色岩燕的适应性筑巢策略：对保护和仿生创新的启示 |
Mukherjee, M. |
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N/A |
Adaptive Nesting Strategies of Dusky Crag Martins in desert ecoregions: Implications for Conservation and Bioinspired Innovations |
| 评估水电大坝梯度下的水禽生物多样性：了解库里楚大坝引起的河流碎片化对库里楚河流域的影响 |
Nidup, T. |
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N/A |
Assessing Aquatic Avian Biodiversity along Hydropower Dam Gradient: Understanding Impacts of Kurichhu Dam-Induced River Fragmentation in Kurrichu River Basin |
| 亚洲狼的复杂基因组祖先及其在南方的分布，以及驱动大陆层面遗传多样性的因素 |
Hennelly, L. |
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N/A |
Complex genomic ancestry in southern regions and drivers of continental-level genetic diversity in the wolves of Asia |
| 在杂交的Mimulus猴面花精细镶嵌体中，繁殖隔离的波动与稳定的祖先结构并存 |
Farnitano, M. C. |
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N/A |
Fluctuating reproductive isolation and stable ancestry structure in a fine-scaled mosaic of hybridizing Mimulus monkeyflowers |
| 现代铁氧化菌支系的近期起源及其铁代谢支系忠诚度较低 |
Tamre, E. |
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N/A |
Recent origin of modern clades of iron oxidizers and low clade fidelity of iron metabolisms |
| gReLU：一种用于DNA序列建模和设计的综合框架 |
Lal, A. |
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N/A |
gReLU: A comprehensive framework for DNA sequence modeling and design |
| 苋菜（Amaranthus palmeri）、反枝苋（Amaranthus retroflexus）和杂交苋（Amaranthus hybridus）的染色体级别基因组组装使得进行基因组比较和鉴定性别决定区域成为可能。 |
Raiyemo, D. A. |
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N/A |
Chromosome-level assemblies of Amaranthus palmeri, Amaranthus retroflexus, and Amaranthus hybridus allow for genomic comparisons and identification of a sex-determining region |
| MoEFold2D：结合深度学习和基于物理的专家混合，保障RNA二级结构预测 |
Qiu, X. |
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N/A |
MoEFold2D: Safeguarding RNA Secondary Structure Prediction with a Mixture of Deep Learning and Physics-based Experts |
| 对葡萄膜黑色素瘤中INPP5A的研究揭示了新的钙瞬变现象 |
Onken, M. D. |
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N/A |
Examination of INPP5A in uveal melanoma uncovers novel calcium transients |
| 突出力和细胞间粘附在肿瘤团簇集体迁移中起着关键作用。 |
Wang, H. |
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N/A |
Protrusion force and cell-cell adhesion play a critical role in collective tumor cluster migration |
| 癌症中整合素蛋白社交网络的全家福光近邻分析 |
Carlos, A. J. |
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N/A |
Family-Wide Photoproximity Profiling of Integrin Protein Social Networks in Cancer |
| 在缺乏调节性T细胞（Tregs）的情况下，IL15/IL15Rα复合物在放射治疗后能够诱导抗肿瘤免疫反应，但无法诱导祖细胞TCF1+ CD8 T细胞的扩增。 |
Piper, M. |
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IL15/IL15Rα complex induces an anti-tumor immune response following radiation therapy only in the absence of Tregs and fails to induce expansion of progenitor TCF1+ CD8 T cells |
| PARP7的丧失增加了I型干扰素信号传导，并通过增强免疫细胞浸润来阻止胰腺肿瘤生长。 |
Kannen, V. |
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N/A |
Loss of PARP7 increases type I interferon signalling and prevents pancreatic tumour growth by enhancing immune cell infiltration |
| 蓝贻贝（Mytilus edulis）中首次发现六鞭毛虫（Hexamita nelsoni）：形态学、系统发育及宿主-寄生虫相互作用 |
Alfjorden, A. |
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N/A |
First report of Hexamita nelsoni in blue mussel (Mytilus edulis): morphology, phylogeny, and host-parasite interaction |
| 不同的疟原虫蛋白激酶在雄性配子发生过程中驱动着微管组织中心、动粒和轴丝的组织结构。 |
Yanase, R. |
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N/A |
Divergent Plasmodium protein kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis |
| 在成年心肌细胞的肌质网/内质网中蛋白质合成网络的发展 |
Sandmann, C. |
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N/A |
Development of a protein synthesis network at the sarco/endoplasmic reticulum in adult cardiac myocytes |
| 脑-体线粒体分布模式缺乏一致性，表明存在组织特异性和个体化的调控机制 |
Devine, J. |
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N/A |
Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific and individualized regulatory mechanisms |
| 在乳腺癌连续模型中，有丝分裂和中心体缺陷的特征 |
Elowe, S. |
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N/A |
A characterization of mitotic and centrosomal defects in a continuum model of Breast Cancer |
| 豚草（Ambrosia artemisiifolia）在不同入侵地快速并行适应的驱动力是大型效应结构变异 |
Battlay, P. |
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Rapid parallel adaptation in distinct invasions of Ambrosia artemisiifolia is driven by large-effect structural variants |
| 欧洲森林和城市绿色空间中宿主-病原体群落组成的驱动因素 |
Sluydts, V. |
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N/A |
Drivers of host-pathogen community assemblies in European forests and urban green spaces |
| 温度依赖性捕食预示着更爬行动物化的未来 |
Grady, J. M. |
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N/A |
Temperature-dependent predation predicts a more reptilian future |
| 多代生物胁迫以ROS1依赖的方式增加了自发表观突变的发生率 |
Zhang, Z. |
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Multi-generational biotic stress increases the rate of spontaneous epimutations in a ROS1-dependent manner |
| 稳定性裕度计算的协调与足长、足宽、步速和体质量影响的探究 |
Dussault-Picard, C. |
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N/A |
Harmonization of Margin of Stability Calculations and Investigation of the Impact of Foot Length, Foot Width, Gait Speed, and Body Mass |
| IgGM：一种用于功能性抗体和纳米抗体设计的生成模型 |
Wang, R. |
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N/A |
IgGM: A Generative Model for Functional Antibody and Nanobody Design |
| 半管道（Halfpipe）：一种用于分析代谢标记RNA-seq数据以量化RNA半衰期的工具 |
Mueller, J. M. |
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N/A |
Halfpipe: a tool for analyzing metabolic labeling RNA-seq data to quantify RNA half-lives |
| 利用生物系统中的代谢探针进行光热红外成像 |
Shuster, S. O. |
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N/A |
Optical photothermal infrared imaging using metabolic probes in biological systems |
| 肺腺癌中Y染色体的选择性丢失通过癌/睾丸抗原调节肿瘤免疫环境 |
Fischer, J. |
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Selective loss of Y chromosomes in lung adenocarcinoma modulates the tumor immune environment through cancer/testis antigens |
| 造血干细胞来源的脂肪细胞消融可减轻同基因小鼠高级别浆液性癌模型中的肿瘤负担 |
Woodruff, E. R. |
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Ablation of hematopoietic stem cell derived adipocytes reduces tumor burden in syngeneic mouse models of high-grade serous carcinoma |
| 一种辅助性NLR能够靶向细胞器膜以触发免疫反应。 |
Ibrahim, T. |
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A helper NLR targets organellar membranes to trigger immunity |
| 淋巴组织趋化因子检查点可防止CD8+ T细胞功能丧失 |
Altenburger, L. M. |
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A lymphoid tissue chemokine checkpoint prevents loss of CD8+ T cell functionality |
| 适应性免疫通过在稳态期间抑制先天淋巴细胞中的持续性IFN-γ，塑造了先天性和上皮细胞的景观。 |
Mejri, O. |
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Adaptive immunity shapes innate and epithelial cell landscapes by silencing tonic IFN-gamma in innate lymphoid cells during homeostasis. |
| 真菌感染的米氏琼楠花朵为三方育幼传粉系统中的甲虫传粉者提供了育幼场所。 |
Liu, M.-F. |
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N/A |
Fungus-infected Meiogyne flowers offer a brood site for beetle pollinators in a tripartite nursery pollination system |
| 采自甜椒的桃蚜对杀虫剂的抗性 |
Beekman, M. M. |
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N/A |
Insecticide resistance in Myzus persicae collected from sweet pepper |
| 一种新型荧光寿命层析成像技术 |
Nizam, N. I. |
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N/A |
A Novel Technique for Fluorescence Lifetime Tomography |
| BioBrigit：一种结合深度学习和基于知识的混合方法，用于蛋白质中金属通路的建模：应用于双铜酪氨酸酶的应用 |
Marechal, J.-D. |
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N/A |
BioBrigit, A Hybrid Deep Learning and Knowledge-based Approach to Model Metal Pathways in Proteins: Application to a Di-Copper Tyrosinase |
| HIV-1核输出复合体揭示了RNA在Crm1货物识别中的作用 |
Smith, A. M. |
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The HIV-1 Nuclear Export Complex Reveals the Role of RNA in Crm1 Cargo Recognition |
| 视网膜母细胞瘤蛋白（Rb）口袋结构域中与癌症相关的错义变异的结构和功能分析 |
Castro, A. |
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N/A |
Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein (Rb) pocket domain |
| 定制基于CRISPR/Cas的表观基因组编辑器以实现可编程染色质乙酰化及降低细胞毒性 |
Goell, J. H. |
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N/A |
Tailoring a CRISPR/Cas-based Epigenome Editor for Programmable Chromatin Acylation and Decreased Cytotoxicity |
| 尿液微生物组与糖尿病及糖尿病肾病的关系：一项系统综述 |
Graells, T. |
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N/A |
The urinary microbiome in association with diabetes and diabetic kidney disease: A systematic review |
| 次黄嘌呤-5'-单磷酸脱氢酶（IMPDH/GuaB）抑制剂对伯氏疏螺旋体在标准及改良培养条件下生长的影响 |
Siegel, E. L. |
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N/A |
Effects of Inosine-5'-Monophosphate Dehydrogenase (IMPDH/GuaB) Inhibitors on Borrelia burgdorferi Growth in Standard and Modified Culture Conditions |
| 常见调控突变提高了铜绿假单胞菌在抗生素暴露下的单细胞存活率。 |
Ritz, D. |
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N/A |
Common regulatory mutation increases single-cell survival to antibiotic exposures in Pseudomonas aeruginosa. |
| 关闭差距：测试碳青霉烯和头孢菌素在治疗晚期炭疽中的疗效 |
Sittner, A. |
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N/A |
Closing the gaps: testing the efficacy of carbapenem and cephalosporins in treating late-stage anthrax |
| 评估氧扰动和过度曝气对活性污泥系统中可溶性微生物产物（SMP）生成和释放的影响 |
Zhou, X. |
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N/A |
Assessing Oxygen Perturbation and Over-Aeration Impacts on Soluble Microbial Products (SMP) Production and Release in Activated Sludge Systems |
| 禽类和牛场作为产ESBL大肠杆菌储库的一体化健康评估 |
Malik, H. |
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N/A |
One Health assessment of poultry and cattle farms as reservoirs for ESBL-producing Escherichia coli |
| 探究氧气扰动下潜在的微生物对代谢物产量增强的贡献：一种整合的宏基因组学和代谢组学方法 |
Zhou, X. |
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N/A |
Investigating Potential Microbial Contributors to Enhanced Metabolite Production under Oxygen Perturbations: An Integrated Metagenomic and Metabolomic Approach |
| 截留末端未脱磷酸的十一碳酰磷酸连接的寡糖中间体 |
Hong, Y. |
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N/A |
Sequestration of dead-end undecaprenyl phosphate-linked oligosaccharide intermediate |
| 通过引导微生物代谢生产高附加值生物化学品，实现废水资源回收 |
Zhou, X. |
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N/A |
Resource Recovery from Wastewater By Directing Microbial Metabolism Toward Production of Value-added Biochemicals |
| 早期生命牛奶饮食塑造婴儿肠道微生物群：关于微生物对母乳和配方奶的适应性证据。 |
Lawson, M. A. E. |
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N/A |
Early life milk diets shape infant gut microbiota: evidence of microbial plasticity in response to breast and formula milk. |
| 水杨酸衍生物的抗结核潜力及其pH驱动的抗菌机制 |
Laudouze, J. |
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N/A |
Anti-tubercular potential and pH-driven mode of action of salicylic acid derivatives |
| 燕麦（Avena sativa L.）对干旱胁迫的蛋白质组响应 |
Chen, C. |
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N/A |
Proteomic responses of oat (Avena sativa L.) to drought stress |
| TDRD3作为一种选择性自噬受体，在自噬过程中具有双重功能，既参与自噬作用，又调节应激颗粒的稳定性。 |
Lloyd, R. E. |
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N/A |
TDRD3 functions as a selective autophagy receptor with dual roles in autophagy and modulation of stress granule stability |
| 寄生传播时间选择塑造了宿主冈比亚按蚊的转录反应，并提示免疫逃避 |
Silva, L. M. |
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N/A |
Selection on time to parasite transmission shapes the host Anopheles gambiae transcriptional response and suggests immune evasion |
| 评估辐射敏感性指数及12种趋化因子基因表达特征在CLIA实验室中的临床应用 |
Berglund, A. |
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N/A |
Evaluating the Radiation Sensitivity Index and 12-chemokine gene expression signature for clinical use in a CLIA laboratory |
| scooby: 在单细胞分辨率下从DNA序列建模多模态基因组特征 |
Gagneur, J. |
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N/A |
scooby: Modeling multi-modal genomic profiles from DNA sequence at single-cell resolution |
| 嵌合去泛素化酶工程揭示了USP30特异性抑制的结构基础及DUB配体结合的框架 |
Kazi, N. H. |
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N/A |
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability |
| 鉴定孤儿GPR25为趋化因子CXCL17的受体 |
Hu, W.-F. |
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N/A |
Identification of the orphan GPR25 as a receptor of the chemokine CXCL17 |
| 通过贝叶斯模型选择整合蛋白质-多肽复合物的建模，使用AlphaFold和NMR化学位移扰动数据 |
Benavides, T. L. |
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N/A |
Integrative Modeling of Protein-Polypeptide Complexes by Bayesian Model Selection using AlphaFold and NMR Chemical Shift Perturbation Data |
| 气道应用的IVT mRNA疫苗需要特定的序列设计和高标准的纯化，以去除具有破坏性的双链RNA污染物。 |
Zhang, J. |
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N/A |
Airway applied IVT mRNA vaccine needs specific sequence design and high standard purification that removes devastating dsRNA contaminant |
| 利用光遗传学技术快速可逆地调控出芽酵母细胞周期进程 |
Koutsoumpa, A. |
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N/A |
Rapid and reversible regulation of cell cycle progression in budding yeast using optogenetics |
| 病毒RNA kaposin促进的核体重组促进了卡波西肉瘤相关疱疹病毒基因表达 |
Kleer, M. |
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N/A |
Nuclear body reorganization by the viral RNA kaposin promotes Kaposi's sarcoma-associated herpesvirus gene expression |
| 评估非洲豆蔻（Aframomum melegueta）和几内亚胡椒（Piper guineense）提取物对黄瓜果实腐烂病原菌的抗菌活性 |
Akpan, P. S. |
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N/A |
Assessing the antimicrobial activity of Aframomum melegueta and Piper guineense extract on pathogens of rot diseases of cucumber fruit |
| BRCA2 C端夹结构重构RAD51二聚体以结合B型DNA，从而维持复制叉的稳定性 |
Longo, M. A. |
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N/A |
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability |
| 一个新颖的OsIAA3-OsARF16-OsBUL1模块调控水稻的粒型 |
Xian, F. |
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N/A |
A novel OsIAA3-OsARF16-OsBUL1 module regulates grain size in rice |
| 基因组大小与非转录区域大小之间的线性相关性 |
Chen, Z.-R. |
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N/A |
The linear correlation between genome size and the size of the non-transcribing region |
| BTFBS：基于深度学习的细菌转录因子与结合位点预测 |
Jin, B. |
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N/A |
BTFBS: binding-prediction of bacterial transcription factors and binding sites based on deep learning |