| 从发育到成年，整合的肢骨单细胞图谱 |
Herpelinck, T. |
PDF |
N/A |
An integrated single-cell atlas of the limb skeleton from development through adulthood |
| 人类语言中的一个伴随放电回路 |
Khalilian-Gourtani, A. |
PDF |
N/A |
A Corollary Discharge Circuit in Human Speech |
| 冬季体重变化在狍（Capreolus capreolus）种群中始终表现出性别特异性。 |
Hewison, A. J. M. |
PDF |
N/A |
Body mass change over winter is consistently sex-specific across roe deer (Capreolus capreolus) populations |
| 优化和基准测试基于全基因组关联研究（GWAS）摘要统计的复杂疾病风险评分 |
Zhao, Z. |
PDF |
N/A |
Optimizing and benchmarking polygenic risk scores with GWAS summary statistics |
| 依赖于价值的突触可塑性在社交情境中驱动接近和回避行为 |
Espinosa, P. |
PDF |
N/A |
Valence-dependent synaptic plasticity drives approach and avoidance behavior in social context |
| 二聚化热力学调控生物相分离 |
Dubach, M. |
PDF |
N/A |
Dimerization thermodynamics govern biological phase separation |
| 利用单细胞RNA测序数据对批量组织中细胞丰度进行独立于聚类的估计 |
Aubin, R. G. |
PDF |
N/A |
Clustering-independent estimation of cell abundances in bulk tissues using single-cell RNA-seq data |
| HiExM：高通量扩展显微技术实现可扩展的超分辨率成像 |
Day, J. H. |
PDF |
N/A |
HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging |
| 急性应激后内啡肽动态变化的高度灵敏体内检测 |
Mikati, M. O. |
PDF |
N/A |
Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress |
| 通过单一类别的中间神经元实现的分层行为控制 |
Huo, J. |
PDF |
N/A |
Hierarchical behavior control by a single class of interneurons |
| 视神经损伤后，ATF4协调激活轴突再生和神经退行性转录程序 |
Somasundaram, P. |
PDF |
N/A |
Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury |
| 泛组织转录组分析揭示了人类衰老的性别二态性 |
Wang, S. |
PDF |
N/A |
Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human Aging |
| 使用视觉悬崖和杆下降实验检测小鼠的双眼干扰 |
De Jesus-Cortes, H. |
PDF |
N/A |
Using the visual cliff and pole descent assays to detect binocular disruption in mice |
| 老年PANX3敲除小鼠的严重骨关节炎：对新型原发性骨关节炎模型的启示 |
Wakefield, B. |
PDF |
N/A |
Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model |
| 通过相位图和模糊递归图探索大脑功能的非线性动力学 |
Li, Q. |
PDF |
N/A |
Exploring Nonlinear Dynamics In Brain Functionality Through Phase Portraits And Fuzzy Recurrence Plots |
| 小脑将输入数据转换成超低分辨率的3D像素。谁知道呢？ |
Gilbert, M. |
PDF |
N/A |
THE CEREBELLUM CONVERTS INPUT DATA INTO HYPER LOW-RESOLUTION 3-D PIXELS. WHO KNEW? |
| 超快功率多普勒超声能够纵向追踪血管变化，这些变化与放射治疗后的免疫反应相关。 |
Martello, S. E. |
PDF |
N/A |
Ultrafast Power Doppler Ultrasound Enables Longitudinal Tracking of Vascular Changes that Correlate with Immune Response After Radiotherapy |
| 癫痫传播在海马局部卒中期间主要在自由活动的雌性小鼠中触发了对侧病灶的扩散性去极化保护反应。 |
Boyce, A. K. |
PDF |
N/A |
Seizure propagation triggers a protective contralesional spreading depolarization during focal hippocampal stroke predominantly in freely behaving female mice |
| 凝聚素在秀丽隐杆线虫中组织围绕活性增强子的三维DNA接触 |
Kim, J. |
PDF |
N/A |
Cohesin organizes 3D DNA contacts surrounding active enhancers in C. elegans |
| 元认知体验的时间动态与任务表现中的理性适应相吻合。 |
Vermeylen, L. |
PDF |
N/A |
The Temporal Dynamics of Metacognitive Experiences Track Rational Adaptations in Task Performance |
| 迷幻剂的协同、多层次理解：对其药理学、神经影像学和现象学的三次系统综述与元分析 |
Shinozuka, K. |
PDF |
N/A |
Synergistic, Multi-level Understanding of Psychedelics: Three Systematic Reviews and Meta-analyses of Their Pharmacology, Neuroimaging and Phenomenology |
| 乳腺导管原位癌的单细胞表达分析揭示了上皮完整性的改变 |
Qin, X. |
PDF |
N/A |
Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity |
| 自闭症候选基因rbm-26（RBM26/27）通过调控MALS-1在神经发育过程中保护线粒体功能和轴突免受退化。 |
Chowdhury, T. A. |
PDF |
N/A |
Autism candidate gene rbm-26(RBM26/27) regulates MALS-1 to protect against mitochondrial dysfunction and axon degeneration during neurodevelopment. |
| 将人口和扩散的时空变化对集合种群增长率的影响进行分区 |
Schreiber, S. |
PDF |
N/A |
Partitioning the Impacts of Spatial-Temporal Variation in Demography and Dispersal on Metapopulation Growth Rates |
| 家麻雀（Passer domesticus）全基因组测序与组装 |
Kumar, V. |
PDF |
N/A |
Whole Genome Sequencing and Assembly of the House Sparrow, Passer domesticus |
| 磷酸蛋白质组学分析鉴定REPS1为骨骼肌中胰岛素和运动应答的葡萄糖摄取信号转导器 |
Kjaergaard, J. |
PDF |
N/A |
Phosphoproteomic Analysis Identifies REPS1 as an Insulin- and Exercise-Responsive Signal Transducer to Glucose Uptake in Skeletal Muscle |
| 一种重要抗寒油菜种质的全基因组组装与基因组结构 |
Wu, Z. |
PDF |
N/A |
Genome assembly and genomic architecture of a prominent cold-resistant rapeseed germplasm |
| 非破坏性X射线断层扫描技术对脑组织超微结构的分析 |
Bosch, C. |
PDF |
N/A |
Non-destructive X-ray tomography of brain tissue ultrastructure |
| 使用Recomb-Mix进行快速准确的本地祖先推断 |
Wei, Y. |
PDF |
N/A |
Fast and accurate local ancestry inference with Recomb-Mix |
| 肿瘤内氯气二氧化物递送利用其类ROS特性：一种有效癌症治疗的新范式 |
Liu, X. |
PDF |
N/A |
Intratumoral Delivery of Chlorine Dioxide Exploits its ROS-like Properties: A Novel Paradigm for Effective Cancer Therapy |
| 高粱基因组-表型关联的GWAS后优先级排序 |
Pal, D. |
PDF |
N/A |
Post-GWAS Prioritization of Genome-Phenome Associations in Sorghum |
| 雌激素对奖赏预测误差和强化学习的影响 |
Golden, C. E. M. |
PDF |
N/A |
Estrogenic control of reward prediction errors and reinforcement learning |
| Sinorhizobium fredii USDA257 的 VI 型分泌系统对于与大豆 Pekin 品种的成功共生是必需的。 |
Reyes-Perez, P. |
PDF |
N/A |
The type VI secretion system of Sinorhizobium fredii USDA257 is required for a successful symbiosis with Glycine max cv Pekin |
| 成年雌性大鼠的嗅鞘细胞是一种混合胶质细胞，能够促进神经修复。 |
Phelps, P. E. |
PDF |
N/A |
Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair |
| 运动记忆形成的核心：双手适应中的时间泛化 |
Howard, I. S. |
PDF |
N/A |
Kernels of Motor Memory Formation: Temporal Generalization in Bimanual Adaptation |
| 脑癌相关结合域突变揭示了CTCF与染色质的关系及其对基因调控的贡献 |
Do, C. |
PDF |
N/A |
Brain and cancer associated binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation |
| 在Pol II触发环单倍型内的高阶上位性 |
Duan, B. |
PDF |
N/A |
Higher-order epistasis within Pol II trigger loop haplotypes |
| 分布式皮层区域在工作记忆存储中具有不同的表征角色 |
Chopurian, V. |
PDF |
N/A |
Distinct representational roles of distributed cortical regions for working memory storage |
| 海洋微生物之间嘌呤和嘧啶交叉喂养的全球生态位划分 |
Braakman, R. |
PDF |
N/A |
Global niche partitioning of purine and pyrimidine cross-feeding among ocean microbes |
| 单核多组学揭示了小鼠原始生殖细胞性别决定背后的基因调控网络 |
Alexander, A. K. |
PDF |
N/A |
Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells |
| 通过序列过滤，反复出现的皮质网络编码了自然感官统计数据。 |
Deveau, C. |
PDF |
N/A |
Recurrent cortical networks encode natural sensory statistics via sequence filtering |
| 评估预训练的DNA语言模型在调控基因组学中的表征能力 |
Tang, Z. |
PDF |
N/A |
Evaluating the representational power of pre-trained DNA language models for regulatory genomics |
| PPFlow：基于扭转流匹配的目标感知肽设计 |
Lin, H. |
PDF |
N/A |
PPFlow: Target-aware Peptide Design with Torsional Flow Matching |
| 脂质过氧化与I型干扰素的耦合作用促进了致病性巨噬细胞的激活，导致结核病易感性增加。 |
Yabaji, S. M. |
PDF |
N/A |
Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility |
| 从表面和深度电极信号进行主题无关的基于Transformer的神经语音解码 |
Chen, J. |
PDF |
N/A |
Subject-Agnostic Transformer-Based Neural Speech Decoding from Surface and Depth Electrode Signals |
| 赋能未来科学家：导师们采用多种策略，引导学生参与专业科学学科素养实践 |
Minocha, T. |
PDF |
N/A |
Empowering future scientists: Mentors employ various strategies to engage students in professional science disciplinary literacy practices |
| MOSAIC：一种高效、一步到位的重组工程方法，用于质粒编辑与多样化 |
van den Brink, M. |
PDF |
N/A |
MOSAIC: a highly efficient, one-step recombineering approach to plasmid editing and diversification |
| 在开花期间，甘蓝型油菜（Brassica napus）长期受到热应激会负面影响产量，并改变硫代葡萄糖苷和糖类的代谢。 |
Kourani, M. |
PDF |
N/A |
Prolonged heat stress in Brassica napus during flowering negatively impacts yield and alters glucosinolate and sugars metabolism |
| Fmo5在杯状细胞成熟和粘液屏障形成中发挥性别特异性作用 |
Schaller, M. L. |
PDF |
N/A |
Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation |
| WHIRLY1 调控拟南芥早期幼苗发育中的脂肪族硫代葡萄糖苷生物合成 |
Nguyen, L. T. |
PDF |
N/A |
WHIRLY1 regulates aliphatic glucosinolate biosynthesis in early seedling development of Arabidopsis |
| 内在单位：识别系统因果关系的颗粒度。 |
Marshall, W. |
PDF |
N/A |
Intrinsic Units: Identifying a system's causal grain. |
| 结肠癌的转移需要Dickkopf-2来生成具有潘氏细胞特性的癌细胞。 |
Shin, J. H. |
PDF |
N/A |
Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties |
| 蜘蛛社会性的基因组后果及持久性 |
Ma, J. |
PDF |
N/A |
The genomic consequences and persistence of sociality in spiders |
| 品尝硬度？植物肉和动物肉的机械特征 |
St. Pierre, S. R. |
PDF |
N/A |
Tasting stiffness? The mechanical signature of plant-based and animal meat |
| 发育中的少突胶质细胞通过调节同步自发活动来调控大脑功能。 |
Masumura, R. |
PDF |
N/A |
Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity |
| 颈动脉体血管紧张素信号的表观遗传上调增加了血压 |
Zhu, F. |
PDF |
N/A |
Epigenetic upregulation of carotid body angiotensin signaling increases blood pressure |
| GeoAB：迈向现实抗体设计与可靠亲和力成熟 |
LIN, H. |
PDF |
N/A |
GeoAB: Towards Realistic Antibody Design and Reliable Affinity Maturation |
| 靶向抗癌前乙烯砜碳酸酐酶IX共价抑制剂 |
Vaskevicius, A. |
PDF |
N/A |
Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX |
| Oxydifficidin是一种强效的淋病奈瑟菌抗生素，其作用机制涉及DedA辅助摄取和核糖体蛋白RplL的敏感性。 |
Kan, J. |
PDF |
N/A |
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity |
| 多组学分析揭示了亚麻荠（Camelina sativa）和其他十字花科植物种子中特化代谢物的组成和空间分布的对比情况。 |
Barreda, L. |
PDF |
N/A |
Multi-omic analyses unveil contrasting composition and spatial distribution of specialized metabolites in seeds of Camelina sativa and other Brassicaceae |
| 分子和空间转录组学分类中脑多巴胺神经元及其在帕金森病LRRK2G2019S模型中的改变 |
Gaertner, Z. |
PDF |
N/A |
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease |
| IGF2BP3通过靶向FBXO32激活cGMP-PKG信号通路，从而促进胃癌的进展。 |
Si, Y. |
PDF |
N/A |
IGF2BP3 promotes the progression of gastric cancer by activating cGMP-PKG signaling pathway via targeting FBXO32 |
| 一种可微分的Gillespie算法，用于模拟化学动力学、参数估计和设计合成生物电路 |
Rijal, K. |
PDF |
N/A |
A differentiable Gillespie algorithm for simulating chemical kinetics, parameter estimation, and designing synthetic biological circuits |
| NR2F2在胚胎睾丸中对胎儿间质细胞的发育是必需的。 |
Perea-Gomez, A. |
PDF |
N/A |
NR2F2 is required in the embryonic testis for Fetal Leydig Cell development |
| 通过圆二色谱和分子建模解析TMPRSS2信使RNA中的鸟嘌呤四链体结构 |
D'Anna, L. |
PDF |
N/A |
Resolving the Structure of a Guanine Quadruplex in TMPRSS2 Messenger RNA by Circular Dichroism and Molecular Modeling |
| 利用大型语言模型解码EB病毒相关疾病的关键靶点和信号通路 |
Yu, J. |
PDF |
N/A |
Decoding critical targets and signaling pathways in EBV-mediated diseases using large language models |
| 7K和11K SomaScan血浆蛋白质组学检测的变异性 |
Candia, J. |
PDF |
N/A |
Variability of 7K and 11K SomaScan plasma proteomics assays |
| 食欲素神经元群体活动精确地反映了在行为和代谢状态下净身体运动的变化。 |
Tesmer, A. L. |
PDF |
N/A |
Orexin population activity precisely reflects net body movement across behavioral and metabolic states |
| 小檗碱是一种新型线粒体钙单向转运体（MCU）抑制剂，能够破坏MCU-EMRE复合体的组装。 |
Zhao, H. |
PDF |
N/A |
Berberine is a novel mitochondrial calcium uniporter (MCU) inhibitor that disrupts MCU-EMRE assembly |
| 通过脑转移性黑色素瘤模型揭示的免疫疗法反应的免疫和分子相关性。 |
Daugherty-Lopes, A. |
PDF |
N/A |
IMMUNE AND MOLECULAR CORRELATES OF RESPONSE TO IMMUNOTHERAPY REVEALED BY BRAIN-METASTATIC MELANOMA MODELS. |
| 果蝇属物种间雌性攻击性的差异是否与繁殖潜力相关？ |
Bath, E. |
PDF |
N/A |
Is variation in female aggressiveness across Drosophila species associated with reproductive potential? |
| 肠道菌群是ALS相关TDP43小鼠性二态性的决定因素 |
Beraldi, E. J. |
PDF |
N/A |
The gut microbiota is a determinant of sexual dimorphism in ALS-linked TDP43 mice |
| 红细胞生成素依赖的CD235a-早期红系祖细胞中CD71hiCD105hi表型的获得 |
Schippel, N. |
PDF |
N/A |
Erythropoietin-dependent Acquisition of CD71hiCD105hi Phenotype within CD235a- Early Erythroid Progenitors |
| 引入白三叶草（Trifolium repens L.）后抗旱策略的演变 |
Hendrickson, B. T. |
PDF |
N/A |
Evolution of drought resistance strategies following the introduction of white clover (Trifolium repens L.) |
| 优化后的扩展显微技术揭示了非洲爪蟾卵提取物中物种特异性的纺锤体微管组织 |
Guilloux, G. |
PDF |
N/A |
Optimized expansion microscopy reveals species-specific spindle microtubule organization in Xenopus egg extracts |
| 适应性觉醒调节：通过儿茶酚胺增强觉醒来药理学地改变耶克斯-多德森曲线的峰值 |
Beerendonk, L. |
PDF |
N/A |
Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal |
| 横断面脑龄评估在预测未来脑变化方面存在局限性。 |
Korbmacher, M. |
PDF |
N/A |
Cross-sectional brain age assessments are limited in predicting future brain change |
| 识别生长分化因子-15作为代谢功能障碍相关脂肪性肝炎的早期预测生物标志物：基于英国生物样本库蛋白质组数据的嵌套病例对照研究 |
Wang, H. |
PDF |
N/A |
Identification of Growth Differentiation Factor-15 as An Early Predictive Biomarker for Metabolic Dysfunction-Associated Steatohepatitis: A Nested Case-control Study of UK Biobank Proteomic Data |
| 肌醇六磷酸（InsP6）通过激活HDAC1/3表观遗传轴来维持肠道屏障功能 |
Chatterjee, S. |
PDF |
N/A |
Inositol Hexaphosphate (InsP6) Activates the HDAC1/3 Epigenetic Axis to Maintain Intestinal Barrier Function |
| ArchMap：基于参考的单细胞数据集分析的网络平台 |
Lotfollahi, M. |
PDF |
N/A |
ArchMap: A web-based platform for reference-based analysis of single-cell datasets |
| 使用整合和抗CRISPR（IntAC）技术在果蝇细胞中进行高分辨率的全基因组CRISPR敲除筛选 |
Viswanatha, R. |
PDF |
N/A |
Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) |
| BrainUnit：将物理单位融入高性能AI驱动的科学计算 |
Wang, C. |
PDF |
N/A |
BrainUnit: Integrating Physical Units into High-Performance AI-Driven Scientific Computing |
| 亚洲狼的复杂基因组祖先及其在南方的分布，以及推动大陆层面遗传多样性的因素 |
Hennelly, L. |
PDF |
N/A |
Complex genomic ancestry in southern regions and drivers of continental-level genetic diversity in the wolves of Asia |
| 造血干细胞来源的脂肪细胞的消融减少了同基因小鼠高级别浆液性癌模型中的肿瘤负担 |
Woodruff, E. R. |
PDF |
N/A |
Ablation of hematopoietic stem cell derived adipocytes reduces tumor burden in syngeneic mouse models of high-grade serous carcinoma |
| 苜蓿（Medicago truncatula）中的CORYNE基因调控花序分生组织分支、营养信号传递以及丛枝菌根共生关系 |
Orosz, J. |
PDF |
N/A |
Medicago truncatula CORYNE regulates inflorescence meristem branching, nutrient signaling, and arbuscular mycorrhizal symbiosis |
| CHAMP1复合物指导异染色质组装并促进同源定向DNA修复 |
Li, F. |
PDF |
N/A |
CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair |
| 在单细胞RNA测序中，利用scPCA联合建模细胞异质性和条件效应 |
Vohringer, H. S. |
PDF |
N/A |
Joint Modeling of Cellular Heterogeneity and Condition Effects with scPCA in Single-Cell RNA-Seq |
| 超级增强子分析揭示了ThPOK/ZBTB7B，作为CD4+细胞谱系承诺因子，是一个主调控因子，限制乳腺癌细胞呈现腔内非迁移表型。 |
Arcuschin, C. D. |
PDF |
N/A |
Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype |
| 丙戊酸对髓母细胞瘤中干细胞性和分化调节因子的调控 |
Freire, N. H. |
PDF |
N/A |
Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma |
| 脂肪细胞代谢状态调节神经胶质细胞的吞噬功能 |
Alassaf, M. |
PDF |
N/A |
Adipocyte metabolic state regulates glial phagocytic function |
| 组成型活性硝酸还原酶的表达增加了尼古丁拟南芥叶片中SARS-CoV-2刺突蛋白的产量，这些叶片原本表现出衰老的特征。 |
Hamel, L.-P. |
PDF |
N/A |
Expression of a constitutively active nitrate reductase increases SARS-CoV-2 Spike protein production in Nicotiana benthamiana leaves that otherwise show traits of senescence |
| 一种基于酵母的反向遗传系统，用于生成编码第八个sgRNA的HCoV-OC43报告病毒 |
Duguay, B. |
PDF |
N/A |
A yeast-based reverse genetics system to generate HCoV-OC43 reporter viruses encoding an eighth sgRNA |
| 五年间关注的新冠病毒变种中，针对刺突蛋白的中和抗体动态变化揭示了保护免受严重COVID-19的保守表位 |
Zayou, L. |
PDF |
N/A |
Dynamics of Spike-Specific Neutralizing Antibodies Across Five-Year Emerging SARS-CoV-2 Variants of Concern Reveal Conserved Epitopes that Protect Against Severe COVID-19 |
| 探索老年人重症COVID-19的生物学机制：来自老年小鼠模型的见解 |
Ma, L. |
PDF |
N/A |
Exploring the Biological Mechanisms of Severe COVID-19 in the Elderly: Insights from an Aged Mouse Model |
| 进化独特的N-糖基依赖性蛋白质质量控制系统在新生隐球菌的细胞适应性和细胞外囊泡运输中发挥着关键作用 |
Mota, C. |
PDF |
N/A |
Evolutionary unique N-glycan-dependent protein quality control system plays pivotal roles in cellular fitness and extracellular vesicle transport in Cryptococcus neoformans |
| 金黄色葡萄球菌酚溶性调节素介导与上呼吸道共生菌的种间竞争 |
Huffines, J. T. |
PDF |
N/A |
Staphylococcus aureus Phenol-Soluble Modulins Mediate Interspecies Competition with Upper Respiratory Commensal Bacteria |
| 细菌细胞大小沿着生长曲线在不同营养条件下进行调节 |
Nieto, C. |
PDF |
N/A |
Bacterial cell size modulation along the growth curve across nutrient conditions |
| 应用hsp60扩增子测序技术来表征与幼年及成年Euprymna scolopes乌贼相关的微生物群落 |
Smith, S. |
PDF |
N/A |
Application of hsp60 amplicon sequencing to characterize microbial communities associated with juvenile and adult Euprymna scolopes squid |
| 对近期出现的猴痘病毒分支的基因组分析揭示了与病毒毒力和传播能力改变相关的基因缺失和单核苷酸多态性。 |
Kumar, A. |
PDF |
N/A |
Genomic analyses of recently emerging clades of mpox virus reveal gene deletion and single nucleotide polymorphisms that correlate with altered virulence and transmission |
| 双转座子测序（Dual Tn-seq）用于探测全基因组范围内的遗传相互作用 |
Zik, J. J. |
PDF |
N/A |
Dual transposon sequencing (Dual Tn-seq) to probe genome-wide genetic interactions |
| 在模拟生理流动的临界摇动速度下培养疟原虫，揭示了入侵配体的新表型 |
Kals, E. |
PDF |
N/A |
Growing Malaria Parasites at a Critical Shaking Speed Mimicking Physiological Flow Reveals New Phenotypes for Invasion Ligands |
| 印度西南海岸孔卡尼人群的母系遗传亲缘关系 |
Sequeira, J. J. |
PDF |
N/A |
Maternal genetic affinities of Konkani population in the southwest coast of India |
| 使用ChemNet建模蛋白质-小分子构象集合 |
Anishchenko, I. |
PDF |
N/A |
Modeling protein-small molecule conformational ensembles with ChemNet |
| Abdala COVID-19疫苗的结构性和功能性糖基化 |
Burnap, S. A. |
PDF |
N/A |
Structural and Functional Glycosylation of the Abdala COVID-19 Vaccine |
| 基于无监督神经网络的膀胱内窥镜图像拼接方法 |
Zixing, Y. |
PDF |
N/A |
Unsupervised Neural Network-Based Image Stitching Method for Bladder Endoscopy |
| 高通量细菌聚集分析在液滴中进行 |
Saar-Abroi, M. |
PDF |
N/A |
High-throughput bacterial aggregation analysis in droplets |
| 在表达沉默抑制因子P19和冠状病毒样颗粒的烟草本塞姆氏烟叶片中发生的分子变化 |
Hamel, L.-P. |
PDF |
N/A |
Molecular changes in agroinfiltrated leaves of Nicotiana benthamiana expressing suppressor of silencing P19 and coronavirus-like particles |
| 成群的细菌表现出发育阶段转变，以在新区域建立分散的菌落。 |
Zdimal, A. M. |
PDF |
N/A |
Swarming bacteria exhibit developmental phase transitions to establish scattered colonies in new regions |
| 通过铜绿假单胞菌对新兴污染物在污水处理厂中的微生物降解 |
Lyu, B. |
PDF |
N/A |
Microbial Degradation of Contaminants of Emerging Concern by Pseudomonas putida in Wastewater Treatment Plants |
| 耐药菌携带者口腔微生物群的改变表现出对革兰氏阴性病原体抑制作用的受损 |
Zelasko, S. |
PDF |
N/A |
Altered oral microbiota of drug-resistant organism carriers exhibit impaired gram-negative pathogen inhibition |
| 感染性SARS-CoV-2 Omicron XBB.1.41.1谱系在圈养的白尾鹿中通过呼吸道排出，且进化速率增加 |
Ferreira, F. C. |
PDF |
N/A |
Respiratory shedding of infectious SARS-CoV-2 Omicron XBB.1.41.1 lineage with increased evolutionary rate among captive white-tailed deer |
| 蛋白质语言模型是否学习了系统发育？ |
Tule, S. |
PDF |
N/A |
Do Protein Language Models Learn Phylogeny? |
| 芳香烃受体在平滑肌细胞中的作用可保护免受二恶英诱导的动脉粥样硬化不良重塑的影响 |
Qin, G. |
PDF |
N/A |
Aryl-hydrocarbon receptor in smooth muscle cells protect against dioxin induced adverse remodeling of atherosclerosis |
| 赫布诱导在发育中的海马体中，向CA3-CA1突触添加了AMPA不稳定的信号单元。 |
Hanse, E. |
PDF |
N/A |
Hebbian induction adds AMPA-labile signaling units to CA3-CA1 synapses in the developing hippocampus |
| 一种稳健且高效的转化方法，适用于最小的支原体细胞 |
Mizutani, M. |
PDF |
N/A |
Robust and highly efficient transformation method for a minimal Mycoplasma cell |
| prfB中程序性核糖体移码的进化与功能意义 |
Prince, C. R. |
PDF |
N/A |
The evolution and functional significance of the programmed ribosomal frameshift in prfB |
| 囊性纤维化痰液中金黄色葡萄球菌生长的遗传需求和营养可用性分析 |
Shull, L. M. |
PDF |
N/A |
Analysis of genetic requirements and nutrient availability for Staphylococcus aureus growth in cystic fibrosis sputum |
| AQP1- 与棕色脂肪组织沉默相关的调节因子 |
Cheng, C. |
PDF |
N/A |
AQP1- A regulatory factor associated with brown adipose tissue silencing |
| 参与蛋白质折叠和染色质组织的基因能够缓冲遗传变异。 |
Frickel, J. |
PDF |
N/A |
Genes involved in protein folding and chromatin organization buffer genetic variation |
| 尼安德特人衍生的变异影响人类疾病位点的颅面增强子活性 |
Uttley, K. |
PDF |
N/A |
Neanderthal-derived variants shape craniofacial enhancer activity at a human disease locus |
| 巨噬细胞在吞噬作用后重新部署功能性癌细胞表面蛋白 |
Volk, R. F. |
PDF |
N/A |
Macrophages redeploy functional cancer cell surface proteins following phagocytosis |
| 适应高压环境：从一种进化出的耐压性增强的大肠杆菌菌株的基因组中获得的见解 |
Allemann, M. N. |
PDF |
N/A |
Adaptation to high pressure; insights from the genome of an evolved Escherichia coli strain with increased piezotolerance |
| 组蛋白去甲基化酶KDM5A和KDM5B通过抑制内源性逆转录病毒元素的转录来调节免疫反应。 |
Chen, H. |
PDF |
N/A |
Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements |
| 几乎完整的人类基因组中复杂的基因变异 |
Logsdon, G. A. |
PDF |
N/A |
Complex genetic variation in nearly complete human genomes |
| 微胶质细胞与胶质母细胞瘤在远端浸润区的相互作用动力学 |
Nebeling, F. C. |
PDF |
N/A |
Dynamics of microglia-glioblastoma crosstalk at the far infiltration zone |
| 益生菌声学生物传感器用于非侵入性肠道炎症成像 |
Buss, M. T. |
PDF |
N/A |
Probiotic acoustic biosensors for noninvasive imaging of gut inflammation |
| MedGraphNet：利用多关系图神经网络和文本知识进行生物医学预测 |
Macaulay, O. |
PDF |
N/A |
MedGraphNet: Leveraging Multi-Relational Graph Neural Networks and Text Knowledge for Biomedical Predictions |
| 吐根生物碱生物合成的独立进化 |
Colinas, M. |
PDF |
N/A |
Independent evolution of ipecac alkaloid biosynthesis |
| 从同质性到异质性：优化基因调控的随机模拟 |
Chae, S. J. |
PDF |
N/A |
From Homogeneity to Heterogeneity: Refining Stochastic Simulations of Gene Regulation |
| 神经成熟提供了表征的稳定性以及理解复杂概念的解决方案 |
Watanabe, H. |
PDF |
N/A |
Neural Maturation Provides the Stability of Representation and the Solution for Understanding Complex Concepts |
| 对小鼠端脑神经上皮顶端核迁移的定量整体活体成像分析 |
Shimamura, T. |
PDF |
N/A |
Quantitative in toto live imaging analysis of apical nuclear migration in the mouse telencephalic neuroepithelium |
| Caveolin-1调控Ewing肉瘤中依赖于环境的信号传导和生存。 |
Segal, D. |
PDF |
N/A |
Caveolin-1 regulates context-dependent signaling and survival in Ewing Sarcoma. |
| GDF3通过改变染色质可及性，促进脂肪组织巨噬细胞介导的炎症反应，这一过程在衰老期间尤为显著。 |
Jang, I. H. |
PDF |
N/A |
GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging |
| ECOLOPES植物模型：一种高分辨率模型，用于模拟城市及其他人为主导和管理环境中的植物群落动态 |
Joschinski, J. |
PDF |
N/A |
The ECOLOPES PLANT MODEL : a high-resolution model to simulate plant community dynamics in cities and other human-dominated and managed environments |
| 易受伤害的驯鹿和驼鹿种群对山松甲虫爆发和管理的反应截然不同。 |
Griffin, L. L. |
PDF |
N/A |
Vulnerable caribou and moose populations display contrasting responses to mountain pine beetle outbreaks and management. |
| 古代多倍体化和染色体丢失率低解释了同型孢子蕨类植物高染色体数的原因。 |
Li, Z. |
PDF |
N/A |
Ancient polyploidy and low rate of chromosome loss explain the high chromosome numbers of homosporous ferns |
| 资源呈现方式决定了酵母的基因和表型适应性。 |
Ahlawat, N. |
PDF |
N/A |
Resource presentation dictates genetic and phenotypic adaptation in yeast. |
| 大规模死亡事件后珊瑚适应与恢复的基因组特征 |
Fifer, J. E. |
PDF |
N/A |
Genomic signatures of coral adaptation and recovery following a mass mortality event |
| 蚊子物种Culex tarsalis的气候适应与遗传分化 |
Liao, Y. |
PDF |
N/A |
Climate Adaptation and Genetic Differentiation in the Mosquito Species Culex tarsalis |
| 体外分析T7 RNA聚合酶生物传感器竞争性抑制模型的研究 |
Delaney, R. M. |
PDF |
N/A |
in vitro analysis of a competitive inhibition model for T7 RNA polymerase biosensors |
| INSPIRE：可解释、灵活且具有空间感知能力的多种来源空间转录组数据集整合 |
Zhao, J. |
PDF |
N/A |
INSPIRE: interpretable, flexible and spatially-aware integration of multiple spatial transcriptomics datasets from diverse sources |
| 使用INMTD进行个体聚类：一种集成组学和影像数据的新型多功能多视角嵌入框架 |
Li, Z. |
PDF |
N/A |
Clustering individuals using INMTD: a novel versatile multi-view embedding framework integrating omics and imaging data |
| RGD-含配体对整合素αVβ3分子识别的结构见解：特异性决定环（SDL）的作用 |
Mariasoosai, C. |
PDF |
N/A |
Structural insights into the molecular recognition of integrin αVβ3 by RGD-containing ligands: The role of the specificity-determining loop (SDL) |
| 类A G蛋白偶联受体（FPR2/ALX）中resolvins D1（RvD1）的进入和结合的结构基础 |
Mun, B. |
PDF |
N/A |
Structural basis for the access and binding of resolvin D1 (RvD1) to formyl peptide receptor 2 (FPR2/ALX), a class A GPCR |
| 胞外相分离介导了甲状腺球蛋白在甲状腺滤泡腔内的储存与释放 |
Knowles, T. |
PDF |
N/A |
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen |
| IGF2BP3通过依赖M6A、独立于帽结构的c-Met翻译促进自噬介导的TNBC转移 |
Wang, Z. |
PDF |
N/A |
IGF2BP3 Promotes Autophagy-Mediated TNBC Metastasis via M6A-Dependent, Cap-Independent c-Met Translation |
| 一个优化的高通量批量RNA-Seq反卷积流程展示了肥胖和体重减轻对人类脂肪组织细胞组成的影响 |
Ahn, C. |
PDF |
N/A |
An optimized pipeline for high-throughput bulk RNA-Seq deconvolution illustrates the impact of obesity and weight loss on cell composition of human adipose tissue |
| 在小鼠骨骼肌中可诱导且可逆的SOD2敲低导致丙酮酸氧化受损和代谢灵活性降低 |
Ostrom, E. L. |
PDF |
N/A |
Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibility |
| 高粱、水稻和玉米中GRAS家族转录因子结合行为的比较研究 |
Gladman, N. P. |
PDF |
N/A |
GRAS Family Transcription Factor Binding Behaviors in Sorghum bicolor, Oyrza, and Maize |
| 靶向CCRL2增强结核病小鼠模型的治疗效果 |
Wang, T. |
PDF |
N/A |
Targeting CCRL2 enhances therapeutic outcomes in a tuberculosis mouse model |
| 穿孔素-2在宿主防御烟曲霉和白色念珠菌方面并非必需。 |
Aufiero, M. |
PDF |
N/A |
Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans |
| 从波兰患有牛呼吸道疾病症状的奶牛犊中分离出的多杀性巴氏杆菌和溶血性曼海姆菌的抗菌药物抗性及毒力相关基因 |
Lachowicz-Wolak, A. |
PDF |
N/A |
Antimicrobial Resistance and Virulence-Associated Genes of Pasteurella multocida and Mannheimia haemolytica Isolated from Polish Dairy Calves with Symptoms of Bovine Respiratory Disease |
| 对日本青鳉在不同大小片段中的环境RNA进行全面测序，并与皮肤RNA进行比较 |
Hiki, K. |
PDF |
N/A |
Comprehensive Sequencing of Environmental RNA from Japanese Medaka at Various Size Fractions and Comparison with Skin RNA |
| 对日本青鳉不同大小片段的环境RNA进行全面测序，并与皮肤RNA进行比较 |
Hiki, K. |
PDF |
N/A |
Comprehensive Sequencing of Environmental RNA from Japanese Medaka at Various Size Fractions and Comparison with Skin RNA |
| 景观分区的模式表明，几内亚狒狒（Papio papio）群体之间存在较低的资源竞争水平。 |
Ohrndorf, L. |
PDF |
N/A |
Patterns of landscape partitioning indicate low levels of resource competition among neighbouring Guinea baboon(Papio papio) parties |
| 在个人基因组和转录组数据上微调序列到表达模型 |
Rastogi, R. |
PDF |
N/A |
Fine-tuning sequence-to-expression models onpersonal genome and transcriptome data |
| ELLA：在高分辨率空间转录组学中建模细胞内基因表达的亚细胞空间变异。 |
Wang, J. |
PDF |
N/A |
ELLA: Modeling Subcellular Spatial Variation of Gene Expression within Cells in High-Resolution Spatial Transcriptomics. |
| 机器人可见光光学相干断层扫描技术可视化了段状施莱姆管的解剖结构及段状毛果芸香碱反应 |
Fang, R. |
PDF |
N/A |
Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemms Canal Anatomy and Segmental Pilocarpine Response |
| 海月：基于语言模型的分子运动预测 |
Lombard, V. |
PDF |
N/A |
SeaMoon: Prediction of molecular motions based on language models |
| 评估帕金森病中α-突触核蛋白寡聚体累积神经毒性的标准 |
Kuznetsov, A. V. |
PDF |
N/A |
Criterion for assessing accumulated neurotoxicity of alpha-synuclein oligomers in Parkinson's disease |
| 使用靶向CRISPR基因编辑技术生成对PARPi敏感的纯合BRCA1甲基化OVCAR8细胞系 |
Nesic, K. |
PDF |
N/A |
Generation of a PARPi-sensitive homozygous BRCA1-methylated OVCAR8 cell line using targeted CRISPR gene editing |
| 利用转录调控网络预测结核分枝杆菌中的细菌适应性：可解释的机器学习方法 |
Bustad, E. |
PDF |
N/A |
Predicting bacterial fitness in Mycobacterium tuberculosis with transcriptional regulatory network-informed interpretable machine learning |
| RNA-DCGen：基于LLM-Attack的双重约束RNA序列生成 |
Shahgir, H. S. |
PDF |
N/A |
RNA-DCGen: Dual Constrained RNA Sequence Generation with LLM-Attack |
| 妊娠期SARS-CoV-2感染的胎盘中显示出氧化应激和DNA损伤的焦点。 |
Nobrega, G. |
PDF |
N/A |
Placentas from SARS-CoV-2 infection during pregnancy exhibit foci of oxidative stress and DNA damage |
| 对来自欧洲和南美洲的四种羊口疮病毒株的全基因组分析。 |
Cacciabue, M. |
PDF |
N/A |
The whole genome analysis of four Orf virus strains from Europe and South America. |
| 新型高质量阿米巴虫基因组揭示巨型病毒与其宿主之间普遍存在的密码子使用不匹配现象 |
Willemsen, A. |
PDF |
N/A |
Novel high-quality amoeba genomes reveal widespread codon usage mismatch between giant viruses and their hosts |
| 果蝇X连锁肾上腺脑白质营养不良ABCD1基因的遗传分析揭示了其在过氧化物酶体动力学中的作用 |
Manor, J. |
PDF |
N/A |
Genetic analysis of the X-linked Adrenoleukodystrophy ABCD1 gene in Drosophila uncovers a role in Peroxisomal dynamics |
| 在基因组学时代计算和解释FST |
de Jong, M. J. |
PDF |
N/A |
Calculating and interpreting FST in the genomics era |
| 从与果蝇相关的三种螺原体（Citri 支系）菌株的草图基因组组装中推断出其毒素库多样但代谢能力有限 |
Ramirez, P. |
PDF |
N/A |
Diverse toxin repertoire but limited metabolic capacities inferred from the draft genome assemblies of three Spiroplasma (Citri clade) strains associated with Drosophila |
| 利用界面张力分选法（SIFT）逐步分离多种代谢细胞群体 |
Shulman, M. |
PDF |
N/A |
Stepwise Isolation of Diverse Metabolic Cell Populations Using Sorting by Interfacial Tension (SIFT) |
| p53motifDB：整合基因组信息与肿瘤抑制因子p53结合基序 |
Baniulyte, G. |
PDF |
N/A |
p53motifDB: integration of genomic information and tumor suppressor p53 binding motifs |
| SARS CoV 2核衣壳蛋白的二聚化结构域在单体状态下部分无序，并形成高亲和力的动态复合物。 |
Cubuk, J. |
PDF |
N/A |
The dimerization domain of SARS CoV 2 Nucleocapsid protein is partially disordered as a monomer and forms a high affinity dynamic complex. |
| 铜绿假单胞菌外膜胞外多糖转运蛋白PelBC的组装与动力学 |
Benedens, M. |
PDF |
N/A |
Assembly and dynamics of the outer membrane exopolysaccharide transporter PelBC of Pseudomonas aeruginosa |
| SUMO2抑制逆转了由滑膜肉瘤融合癌蛋白驱动的异常表观遗传重编程，并损害了肉瘤发生 |
Iyer, R. |
PDF |
N/A |
SUMO2 Inhibition Reverses Aberrant Epigenetic Rewiring Driven by Synovial Sarcoma Fusion Oncoproteins and Impairs Sarcomagenesis |
| 利用深度学习技术对化石禾本科花粉的超分辨率图像进行分析，重构古草原的多样性动态变化 |
Adaime, M.-E. |
PDF |
N/A |
Reconstructing the diversity dynamics of paleo-grasslands using deep learning on superresolution images of fossil Poaceae pollen |
| XXX和XXY三倍体大麻的性表达、生物量、大麻素含量及种子产量的比较 |
Paul, N. |
PDF |
N/A |
A Comparison of the Sexual Expression, Biomass, Cannabinoid Content, and Seed Production in XXX and XXY Triploid Cannabis |
| 用于测试抗SARS-CoV-2炎症化合物的炎症细胞平台（INCEPLAT） |
LOPEZ-AYLLON, B. D. |
PDF |
N/A |
Inflammation cellular platform (INCEPLAT) for testing anti-inflammatory compounds for SARS-CoV-2 |
| SARS-CoV-2 ORF3a蛋白损害合胞体滋养层细胞的成熟，改变ZO-1的定位，并在滋养层细胞和三维类器官中改变自噬途径 |
Kumar, D. |
PDF |
N/A |
SARS-CoV-2 ORF3a Protein Impairs Syncytiotrophoblast Maturation, Alters ZO-1 Localization, and Shifts Autophagic Pathways in Trophoblast Cells and 3D Organoids |
| 由丙酮酸脱氢酶驱动的碳水化合物燃料的线粒体氧化作用显著增强了老年和老年期肠干细胞的干性。 |
Ahmed, S. |
PDF |
N/A |
Mitochondrial oxidation of the carbohydrate fuel driven by pyruvate dehydrogenase robustly enhances stemness of older and geriatric Intestinal Stem Cells |
| GATA2缺乏综合征中的血液学表型源于继发性损伤和对增殖的适应不良。 |
Fernandez-Orth, J. |
PDF |
N/A |
Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferation |
| 感染负荷的均值和方差揭示了未被察觉的宿主进化 |
Walsman, J. C. |
PDF |
N/A |
The mean and variance of infection load reveal unseen host evolution |
| 昆虫神经性别决定系统的演化：蟋蟀中的doublesex同源基因作为X连锁的雄性化因子，调节形态学上的性别二型性，但不影响行为上的性别二型性。 |
Watanabe, T. |
PDF |
N/A |
Evolution of the neural sex-determination system in insects: The doublesex homolog in crickets functions as an X-linked masculinizing factor to regulate morphological but not behavioral sexual dimorphism |
| 钙黏蛋白16通过斯塔尼乌斯内分泌小体促进感觉门控 |
Schloss, S. S. |
PDF |
N/A |
Cadherin 16 promotes sensory gating via the endocrine corpuscles of Stannius |
| 基于长读长全基因组测序的单细胞同时单倍型分型与非整倍体分析 |
Zhao, Y. |
PDF |
N/A |
Long-read whole-genome sequencing-based concurrent haplotyping and aneuploidy profiling of single cells |
| 伤口闭合过程中EDA纤连蛋白微结构与YAP易位的关系 |
Patten, J. |
PDF |
N/A |
EDA Fibronectin Microarchitecture and YAP Translocation During Wound Closure |
| 不同前列腺癌模型中的氧化磷酸化抑制及其与雄激素受体信号的相互作用 |
Sakellakis, M. |
PDF |
N/A |
Oxidative Phosphorylation Inhibition in Different Prostate Cancer Models and the Interplay with Androgen Receptor Signaling |
| 高维中介分析与网络中介：应用于儿童急性淋巴细胞白血病 |
Wang, J. |
PDF |
N/A |
High-Dimensional Mediation Analysis with Network Mediators: Applications to Pediatric Acute Lymphoblastic Leukemia. |
| 视觉雪花症患者的方向运动敏感性受到拖尾型视物残留存在的影响而发生调节。 |
Obukhova, T. S. |
PDF |
N/A |
Directional motion sensitivity in people with Visual Snow Syndrome is modulated by the presence of trailing-type palinopsia |
| 自闭症谱系障碍中社会视觉通路的破坏 |
Li, C. |
PDF |
N/A |
Disruption of the Social Visual Pathway in Autism Spectrum Disorder |
| 自身抗体针对干扰素在慢性乙型肝炎病毒感染者中较为常见，并与聚乙二醇干扰素治疗无应答相关。 |
Fink, D. L. |
PDF |
N/A |
Auto-antibodies against interferons are common in people living with chronic hepatitis B virus infection and associate with PegIFN non-response |
| 通用感受系统作为金黄色葡萄球菌转录组活动的新型调节器 |
Tetz, G. |
PDF |
N/A |
Universal Receptive System as a novel regulator of transcriptomic activity of Staphylococcus aureus |
| 阿尔伯塔首次记录库蚊（双翅目：蚊科）：加拿大西部省份分布范围扩大及生态型模式 |
Soghigian, J. |
PDF |
N/A |
First record of Culex pipiens (Diptera: Culicidae) in Alberta: Expanding distributions and ecotype patterns in a western Canadian province |
| 隐形人群：探究遥感数据集如何揭示森林周边人口的分布情况 |
Rakotoarisoa, M. |
PDF |
N/A |
Invisible people: Exploring how well remote-sensed datasets reveal the distribution of forest-proximate populations |
| 萤火虫Photinus pyralis中色素在光色变化中的作用 |
Popecki, M. S. |
PDF |
N/A |
The role of pigments in light color variation of the firefly Photinus pyralis |
| 通过ATAC-seq定义的足迹QTLs鉴定与转录因子结合相关的非编码变异的特征，在肝脏中的研究 |
Dudek, M. F. |
PDF |
N/A |
Characterization of non-coding variants associated with transcription factor binding through ATAC-seq-defined footprint QTLs in liver |
| 物种间连锁不平衡图谱 |
Zhu, T.-N. |
PDF |
N/A |
An Atlas of Linkage Disequilibrium Across Species |
| Sost mRNA和Sclerostin在体内机械负荷下的三维空间分布 |
Meslier, Q. A. |
PDF |
N/A |
3D spatial distribution of Sost mRNA and Sclerostin expression in response to in vivo mechanical loading |
| 发芽糙米研究：进展、热点与趋势的文献计量分析 |
Zhang, W. |
PDF |
N/A |
Germinated brown rice research: bibliometric analysis of progress, hotspots and trends |
| 利用神经网络校正FoldX自由能估算 |
Barnes, J. E. |
PDF |
N/A |
Leveraging neural networks to correct FoldX free energy estimates |
| nSMase2介导的外泌体分泌塑造了肿瘤微环境，以免疫学方式支持胰腺癌 |
Hendley, A. M. |
PDF |
N/A |
nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer |
| 糖饮食对蚊子湿度偏好、存活率及宿主降落的影响 |
Chen, S.-C. |
PDF |
N/A |
The impact of sugar diet on humidity preference, survival, and host landing in mosquitoes |
| 从头设计平行和反平行A3B3异源六聚体α螺旋桶 |
Chubb, J. J. |
PDF |
N/A |
De novo design of parallel and antiparallel A3B3 heterohexameric alpha-helical barrels |
| 生物系统中反馈调节的鲁棒性基本权衡 |
Tran, N. H. N. |
PDF |
N/A |
Fundamental trade-offs in the robustness of biological systems with feedback regulation |
| 分裂RNA开关：通过预翻译和翻译后调控的集合实现基因表达的可编程和精确控制 |
Abe, I. |
PDF |
N/A |
Split RNA switch: Programmable and precise control of gene expression by ensemble of pre- and post-translational regulation |
| 通过亚洲乳腺癌转录组测序检测肿瘤内微生物群 |
Yeo, L.-F. |
PDF |
N/A |
Detection of intra-tumoral microbiota from transcriptomic sequencing of Asian breast cancer |
| 肠道微生物群移植后定植失败加剧了DSS诱导的结肠炎 |
Gustafson, K. L. |
PDF |
N/A |
Failure of colonization following gut microbiota transfer exacerbates DSS-induced colitis |
| 甲型流感病毒通过细胞凋亡的启动诱导形成类似隧道纳米管的结构。 |
Weir, D. |
PDF |
N/A |
Influenza A viruses induce tunnelling nanotube-like structures through the onset of apoptosis |
| 人α-防御素中和AAV2的机制 |
Porter, J. M. |
PDF |
N/A |
Mechanisms of AAV2 neutralization by human alpha-defensins |
| 非光学、无标记的微生物电容成像技术 |
Incandela, J. T. |
PDF |
N/A |
Non-Optical, Label-free Electrical Capacitance Imaging of Microorganisms |
| 掌握纯细菌菌株对微污染物完全分解的限制：一项蛋白质组学和动力学研究 |
Gordillo, A. P. L. |
PDF |
N/A |
Grasping the constraints of pure bacterial strains for the complete catabolism of micropollutants: a proteomic and kinetic study |
| 铜绿假单胞菌LasR缺陷型突变体由于细胞内谷胱甘肽水平较低，表现出对甲基乙二醛和过氧化氢的敏感性增加。 |
Ruzic, M. |
PDF |
N/A |
Pseudomonas aeruginosa LasR-deficient mutants have increased methylglyoxal and hydrogen peroxide sensitivity due to low intracellular glutathione |
| 河流至湖泊连续体中的异养固氮作用：生活方式及其对氮气固定的贡献 |
Geisler, E. |
PDF |
N/A |
Heterotrophic diazotrophy along a river to lake continuum: lifestyle and contribution to N2 fixation |
| 耐碳青霉烯类肠杆菌霍氏菌利用黏液代谢促进胃肠道定殖 |
Sinha, R. |
PDF |
N/A |
Carbapenem-Resistant Enterobacter hormaechei Uses Mucus Metabolism to Facilitate Gastrointestinal Colonization |
| 利用动态核极化增强的固态核磁共振技术对天然细菌生物膜进行高灵敏度分析 |
Byeon, C.-H. |
PDF |
N/A |
High-Sensitivity Analysis of Native Bacterial Biofilms Using Dynamic Nuclear Polarization-Enhanced Solid-State NMR |
| 在公共蛋白质数据库中的未表征序列中，发现了数百种外源性和内源性RNA病毒RdRp序列。 |
Brown, K. |
PDF |
N/A |
Uncovering hundreds of exogenous and endogenous RNA viral RdRp sequences amongst uncharacterised sequences in public protein databases |
| 白色念珠菌和金黄色葡萄球菌相互促进致病因素的分泌。 |
Pasman, R. |
PDF |
N/A |
Candida albicans and Staphylococcus aureus reciprocally promote secretion of virulence factors |
| 鉴定出一种属于“flexivirus”相关家族的新型真菌病毒，其病毒粒子呈二十面体结构 |
Wu, C.-F. |
PDF |
N/A |
Identification of a novel mycovirus belonging to the ''flexivirus''-related family with icosahedral virion |
| 鼻腔微生物群在人类鼻腔上皮类器官中差异定植并诱导细胞因子产生 |
Boyd, A. I. |
PDF |
N/A |
Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids |
| 在虾生长的早期阶段施用钼酸盐可抑制虾池底部模型中硫化物的形成 |
Torun, F. |
PDF |
N/A |
Molybdate application in the early stages of shrimp growth suppresses sulphide formation in a shrimp pond bottom model |
| 一种用于评估正布尼亚病毒神经疾病遗传决定因素的混合搭配反向遗传系统 |
Miettinen, H. M. |
PDF |
N/A |
A mix-and-match reverse genetics system for evaluating genetic determinants of orthobunyavirus neurological disease |
| 重新审视氧毒性：超氧化物在缺乏SOD的细菌病原体中的进化与适应 |
Huete, S. G. |
PDF |
N/A |
Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen |
| 内生真菌枝孢菌BRN05的α-葡萄糖苷酶抑制活性和基于UHPLC-ESI-QTOF-MS的代谢谱分析，该菌株分离自大叶桃花心木的种子。 |
Kumar, P. |
PDF |
N/A |
Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungi Alternaria sp. BRN05. isolated from seeds of Swietenia macrophylla King. |
| DNA甲基化和去甲基化驱动的脓毒症调控 |
Saini, A. K. |
PDF |
N/A |
DNA methylation and demethylation driven regulation of sepsis |
| 一个赋能基因通路发现和基因表达辅助疾病分类的图谱引导框架 |
Wang, Y. |
PDF |
N/A |
A Graph Informed Framework Empowering Gene Pathway Discovery and Gene Expression-Assisted Disease Classification |
| 通过使用具有一致N-连接糖基化抗原的HDX-MS实现糖蛋白的表位分析 |
Ota, T. |
PDF |
N/A |
Enabling Epitope Analysis of Glycoproteins via HDX-MS Using Antigens with Uni-formed N-linked Glycans |
| 肌肉协同作用在神经肌肉骨骼建模中减少肌电图通道数量的初步研究 |
Romanato, M. |
PDF |
N/A |
Muscle synergies to reduce the number of electromyography channels in neuromusculoskeletal modelling: a pilot study |
| varCADD：大量现有的遗传变异数据能够实现全基因组致病性预测 |
Nazaretyan, L. |
PDF |
N/A |
varCADD: large sets of standing genetic variation enable genome-wide pathogenicity prediction |
| III型CRISPR-Cas位点中的环状核酸酶的多样性和丰度 |
Hoikkala, V. |
PDF |
N/A |
Diversity and abundance of ring nucleases in type III CRISPR-Cas loci |
| 乳腺癌球体偏好活化的巨噬细胞作为共犯：一项体外研究 |
Teli, A. |
PDF |
N/A |
Breast cancer spheroids prefer activated macrophages as an accomplice: An in vitro study |
| 多发性硬化症皮质中β淀粉样蛋白减少和神经原纤维缠结减少的神经病理学证据 |
Pansieri, J. |
PDF |
N/A |
Neuropathological evidence of reduced amyloid beta and neurofibrillary tangles in multiple sclerosis cortex |
| 利用工程环境细菌降解PET塑料 |
Banks, A. M. |
PDF |
N/A |
Degradation of PET plastic with engineered environmental bacteria |
| 真核生物可编程基因表达的正交转录引擎的定向进化 |
Kar, S. |
PDF |
N/A |
Directed evolution of an orthogonal transcription engine for programmable gene expression in eukaryotes |
| 信号序列将酶和结构蛋白靶向细菌微区室，对微区室的形成至关重要。 |
Johnson, E. R. |
PDF |
N/A |
Signal sequences target enzymes and structural proteins to bacterial microcompartments and are critical for microcompartment formation |
| 鸟类干扰素调节因子（IRF）家族团聚：IRF3与IRF9相聚 |
Ungrova, L. |
PDF |
N/A |
Avian interferon regulatory factor (IRF) family reunion: IRF3 and IRF9 found |
| SbcB 以不依赖核酸外切酶的方式促进霍乱弧菌的自然转化 |
Dalia, T. N. |
PDF |
N/A |
SbcB facilitates natural transformation in Vibrio cholerae in an exonuclease-independent manner |
| 完整细菌鞭毛的细胞外结构揭示了鞭毛蛋白插入的机制 |
Einenkel, R. |
PDF |
N/A |
Structure of the complete extracellular bacterial flagellum reveals mechanism for flagellin incorporation |
| 培养的肺泡基底细胞显示出与气道基底细胞相似的特征和功能特性。 |
Blumer, S. |
PDF |
N/A |
Cultured alveolar basal cells display similar characteristics and functional properties to airway basal cells |
| 人类GPR155的冷冻电镜结构揭示了其调控和转运机制 |
Sharma, M. |
PDF |
N/A |
Cryo-EM structures of human GPR155 elucidate its regulatory and transport mechanisms |