| 一项miRNA筛选发现了一个调控成年干细胞命运的转录程序 |
Robert, J. |
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N/A |
A miRNA screen identifies a transcriptional program controlling the fate of adult stem cell |
| Cul3泛素连接酶通过与Insomniac作为适配器相互作用，影响睡眠和突触稳态。 |
Li, Q. |
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N/A |
The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis |
| Swi6/HP1与siRNA-DNA杂交体的H3-K9-me非依赖性结合在小孢子酵母中启动了在同源dg-dh重复序列处的异染色质组装 |
Singh, J. |
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An H3-K9-me-independent binding of Swi6/HP1 to siRNA-DNA hybrids initiates heterochromatin assembly at cognate dg-dh repeats in Fission Yeast |
| 深度学习和跨物种分析揭示了性别和大麻素信号传导对小脑蚓部形态的影响 |
Black, K. C. |
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N/A |
Deep learning and cross-species analysis identify the influences of sex and cannabinoidsignaling on cerebellar vermis morphology |
| SATB1通过结合到碱基不配对区域（BURs）来组织基因组，为SATB1调控的基因表达提供支架。 |
Kohwi, Y. |
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N/A |
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides scaffold for SATB1-regulated gene expression |
| 更年期男性？对果蝇进行的伴侣选择理论实验验证表明，两性都可能经历更年期 |
Purohith, D. |
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N/A |
Men in menopause? Experimental verification of the mate choice theory with Drosophila melanogaster shows both sexes can undergo menopause |
| 高曝光度差异使得在小规模甲基汞暴露的秘鲁成年人EWAS中能够检测到候选生物标志物 |
Weinhouse, C. |
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N/A |
High exposure variance enables candidate biomarker detection in a small EWAS of methylmercury-exposed Peruvian adults |
| 大鼠非桶状体感皮层的建模与仿真。第一部分：解剖建模 |
Reimann, M. W. |
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N/A |
Modeling and Simulation of Rat Non-Barrel Somatosensory Cortex. Part I: Modeling Anatomy |
| 基于模型的压缩感知实现了从全息集合刺激中快速学习神经回路 |
Triplett, M. A. |
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N/A |
Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing |
| 全脑范围的突触蛋白周转测量揭示了学习过程中局部可塑性的存在 |
Mohar, B. |
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N/A |
Brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning |
| 有其母必有其女？孤雌生殖黄蜂体型表型可塑性、环境协变及遗传力研究 |
Tovar, A. |
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N/A |
Like mother, like daughter? Phenotypic plasticity, environmental covariation, and heritability of size in a parthenogenetic wasp |
| 多蛋白信号复合物维持AKT和mTOR/S6K活性，这对处于压力下的癌细胞的生存是必需的。 |
Teran Pumar, O. Y. |
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N/A |
A multiprotein signaling complex sustains AKT and mTOR/S6K activity necessary for the survival of cancer cells undergoing stress |
| PRDM16在BMP通路中作为共抑制因子，抑制神经干细胞的增殖。 |
He, L. |
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N/A |
PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation |
| 预测内在无序蛋白质的序列依赖性骨架动力学 |
Qin, S. |
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N/A |
Predicting the Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins |
| 单核细胞毒素引起破坏性的Sec61依赖性内皮糖萼和血管基底膜丧失：结核分枝杆菌感染中驱动组织坏死的新间接机制 |
Hsieh, L. T.-H. |
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N/A |
Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection |
| 全脑血容量变化驱动人类宏观脑脊液流动 |
Zimmermann, J. |
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N/A |
Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans |
| Detect+Track：用于改进鱼类跟踪和行为分析的稳健且灵活的软件工具 |
Dutta, A. |
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N/A |
Detect+Track: Robust and flexible software tools for improved tracking and behavioural analysis of fish |
| 通过从整体到单细胞的反卷积方法，分析白血病干细胞的药物敏感性 |
Alexandre, C. |
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N/A |
Profiling drug sensitivity of leukemic stem cells via bulk-to-single-cell deconvolution |
| 代谢网络中切换节点的计算机模拟识别 |
Mairet, F. |
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N/A |
In silico identification of switching nodes in metabolic networks |
| 肌动蛋白-TFII-IΔ通过形态力学调节ERK的调谐，调控细胞身份 |
Wu, Q. |
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N/A |
Morphomechanic tuning of ERK by actin-TFII-IΔ regulates cell identity |
| 在有限时间内进行高效的数量估计 |
Heng, J. A. |
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N/A |
Efficient numerosity estimation under limited time |
| 系统比较了用于表达预测的计算方法 |
Kernfeld, E. |
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N/A |
A systematic comparison of computational methods for expression forecasting |
| 结合视频遥测和可穿戴式MEG进行自然主义成像 |
O'Neill, G. C. |
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N/A |
Combining video telemetry and wearable MEG for naturalistic imaging |
| 长期光生物调节对小鼠衰老的治疗效果 |
Ahmet, I. |
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N/A |
The Therapeutic Effects of Long-term Photobiomodulation on Aging in Mice |
| 推进蛋白质-DNA结合位点预测：整合序列模型与机器学习分类器 |
Murad, T. |
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N/A |
Advancing Protein-DNA Binding Site Prediction: Integrating Sequence Models and Machine Learning Classifiers |
| 孕酮通过两个具有PLA2活性的必需共受体诱导减数分裂 |
Nader, N. |
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N/A |
Progesterone induces meiosis through two obligate co-receptors with PLA2 activity |
| Kdm6a和Kdm6b在调节哺乳动物神经再生中的作用 |
Yang, S.-G. |
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N/A |
Roles of Kdm6a and Kdm6b in regulation of mammalian neural regeneration |
| 通过依赖泛素化的TEAD降解靶向癌症中的Hippo通路 |
Pham, T. H. |
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N/A |
Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation |
| SARS-CoV-2刺突抗体与登革病毒发生交叉反应，并在体外和体内增强感染 |
Jakhar, K. |
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N/A |
SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in-vitro and in-vivo |
| STING 通过 HOIP 介导的 M1 泛素链合成来刺激 NFkB 信号传导 |
Fischer, T. D. |
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STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NFkB signaling |
| 互助主义者提供的资源增加了对寄生虫的易感性 |
Yi, E. |
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N/A |
Mutualist-Provided Resources Increase Susceptibility to Parasites |
| 人类第二视觉区域中颜色、视差和自然纹理的中尺度功能组织与连接性 |
Ai, H. |
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N/A |
Mesoscale functional organization and connectivity of color, disparity, and naturalistic texture in human second visual area |
| 优化Niosome制剂以增强细胞应用：与L-α-卵磷脂脂质体的比较案例研究 |
Cakir, N. |
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N/A |
Optimizing Niosome Formulations for Enhanced Cellular Applications: A Comparative Case Study with L-α-lecithin Liposomes |
| 一种高效的计算方法，用于生成具有常染色体三体的阳性NIPT样本 |
Nguyen Huy, T. |
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N/A |
An Efficient Computational Method to Create Positive NIPT Samples with Autosomal Trisomy |
| 量化分层肌肉相互作用对运动功能的多样化贡献 |
O'Reilly, D. |
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N/A |
Quantifying the diverse contributions of hierarchical muscle interactions to motor function |
| 在站立平衡过程中皮质对姿势摇摆的追踪。 |
Legrand, T. |
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N/A |
Cortical tracking of postural sways during standing balance. |
| 利用scATAC-seq在不同免疫细胞类型和背景下对eQTL和哮喘风险位点进行功能性表征 |
Wei, J. |
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N/A |
Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts |
| 诱导后的幂律行为短暂存在，这有助于区分竞争性随机基因表达模型之间的差异。 |
Nicoll, A. G. |
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N/A |
Transient power-law behaviour following induction distinguishes between competing models of stochastic gene expression |
| 在密集混合神经培养物中无偏倚地鉴定细胞身份 |
De Beuckeleer, S. |
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N/A |
Unbiased identification of cell identity in dense mixed neural cultures |
| 通过选择性注意动态调节表征轨迹 |
Zhou, Y. |
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N/A |
Dynamic Modulation of Representational Trajectories Through Selective Attention |
| 有机大分子在输送珍珠层形成所需钙前体的过程中占据了相当大的比例。 |
Macias-Sanchez, E. |
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N/A |
Organic macromolecules transport a significant proportion of the calcium precursor for nacre formation. |
| 基于相关自然统计的高效编码解释的重量错觉 |
Bays, P. |
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N/A |
Weight illusions explained by efficient coding based on correlated natural statistics |
| 鸣禽听觉前脑中用于声音交流信号的预测和错误编码 |
Rudraraju, S. |
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N/A |
Predictive and error coding for vocal communication signals in the songbird auditory forebrain |
| 基因表达在富含调控基序的基因组区域中的出现与演化 |
Fuqua, T. |
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N/A |
The emergence and evolution of gene expression in genome regions replete with regulatory motifs |
| 与阿片类药物使用障碍的大鼠行为模型中的个体差异相关的前额叶皮质中的差异基因表达和染色质可及性 |
Liu, S. X. |
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N/A |
Differential gene expression and chromatin accessibility in the medial prefrontal cortex associated with individual differences in rat behavioral models of opioid use disorder |
| 自闭症相关的PTCHD1错义变异体能与SNARE相关蛋白SNAPIN结合，但表现出细胞内运输障碍。 |
Pastore, S. F. |
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N/A |
Autism-associated PTCHD1 missense variants bind to the SNARE-associated protein, SNAPIN, but exhibit impaired subcellular trafficking |
| 一种用于评估生物化学领域模型分布外表现的新框架 |
Fernandez-Diaz, R. |
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N/A |
A new framework for evaluating model out-of-distribution for the biochemical domain |
| MixtureFinder：用于系统发育分析的DNA混合模型估计 |
Ren, H. |
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N/A |
MixtureFinder: Estimating DNA mixture models for phylogenetic analyses |
| 新兴细菌性植物病原体的多样化；从全球蔓延的穿孔黄单胞菌中获得的见解 |
Timilsina, S. |
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N/A |
Diversification of an emerging bacterial plant pathogen; insights from the global spread of Xanthomonas euvesicatoria pv. perforans |
| 饮食调控背外侧纹状体中的沉默突触 |
Meyers, A. M. |
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N/A |
Dietary regulation of silent synapses in the dorsolateral striatum |
| 解析轴突转录组图谱：从诱导多能干细胞衍生的皮层神经元中获得的见解及其对运动神经元退化的意义 |
Xu, J. |
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N/A |
Unraveling Axonal Transcriptional Landscapes: Insights from iPSC-Derived Cortical Neurons and Implications for Motor Neuron Degeneration |
| BindCompare：一种新颖的蛋白质-核酸结合分析综合平台 |
Mahableshwarkar, P. |
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N/A |
BindCompare: A Novel Integrated protein-nucleic Acid Binding Analysis Platform |
| CCDC113稳定精子轴丝和头尾耦合装置，以确保男性生育能力 |
Wu, B. |
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N/A |
CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility |
| 基于定向进化的配体体内再刺激CAR-T细胞的发现 |
Grzywa, T. |
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N/A |
Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells |
| 猕猴V1中上下文调制的依赖性对层间信号流动的影响 |
Zhu, S. |
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N/A |
Dependence of Contextual Modulation in Macaque V1 on Interlaminar Signal Flow |
| 高加索侏儒虾虎鱼（Knipowitschia cf. caucasica）染色体水平基因组参考，这是一种新入侵莱茵河的虾虎鱼科外来物种 |
Schoenle, A. |
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N/A |
Chromosome level genome reference of the Caucasian dwarf goby Knipowitschia cf. caucasica, a new alien Gobiidae invadingthe River Rhine |
| 社会地位对非洲慈鲷后续求偶和交配活动的影响 |
Martashvili, A. |
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N/A |
Effects of social position on subsequent courtship and mating activity in an African cichlid |
| 对500个人类蛋白质域进行定点饱和诱变，揭示了蛋白质失稳对遗传疾病的贡献 |
Beltran, T. |
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N/A |
Site saturation mutagenesis of 500 human protein domains reveals the contribution of protein destabilization to genetic disease |
| 利用贝叶斯参数估计与条件变分自编码器识别肌肉中的机制与治疗靶点 |
Tune, T. C. |
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N/A |
Identifying mechanisms and therapeutic targets in muscle using Bayesian parameter estimation with conditional variational autoencoders |
| 特定的有丝分裂事件驱动细胞骨架重塑，这是左右器官发育所必需的。 |
Wu, Y. |
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N/A |
Specific Mitotic Events Drive Cytoskeletal Remodeling Required for Left-Right Organizer Development |
| 单细胞基因型-表型映射识别VEXAS综合征的治疗脆弱性 |
Ganesan, S. |
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N/A |
Single-cell genotype-phenotype mapping identifies therapeutic vulnerabilities in VEXAS syndrome |
| 瞳孔流形：揭示瞳孔大小相位变化背后的潜在几何结构 |
Blini, E. |
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N/A |
Pupillary manifolds: uncovering the latent geometrical structures behind phasic changes in pupil size |
| 植物质外体中的枯草杆菌蛋白酶SBT5.2能灭活鞭毛蛋白的免疫原性 |
Buscaill, P. |
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N/A |
Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast |
| 通过活益生菌细菌刺激，对源自健康人结肠类器官的上皮组织和癌细胞系进行全面的基因表达分析 |
Sen, A. |
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N/A |
Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line by stimulated with live probiotic bacteria |
| 通过Talin激活β2整合素的分子基础揭示了整合素信号传导的物种特异性机制 |
Wu, J. |
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N/A |
Molecular Basis of β2 Integrin Activation by Talin Unveils Species-Specific Mechanisms of Integrin Signaling |
| 进化视角下的观赏金鱼双尾肌肉纤维分布研究 |
Ota, K. |
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N/A |
Evolutionary Insights into Muscle Fiber Distribution in the Twin Tails of Ornamental Goldfish |
| 视网膜祖细胞中TET家族基因的遗传缺失会损害光感受器发育并导致失明 |
Dvoriantchikova, G. |
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N/A |
Genetic ablation of the TET family in retinal progenitor cells impairs photoreceptor development and leads to blindness |
| 链霉菌天蓝色菌收缩注射系统的功能和激发需要膜蛋白CisA |
Casu, B. |
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N/A |
Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA |
| 小脑作为强化学习机器的尖峰神经网络模型 |
Kuriyama, R. |
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N/A |
Spiking network model of the cerebellum as a reinforcement learning machine |
| 利用Coronin 1作为模板，开发基于肽的融合抑制剂作为抗病毒策略 |
Panda, M. S. |
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N/A |
Developing peptide-based fusion inhibitors as an antiviral strategy utilizing Coronin 1 as a template |
| 传染性喉气管炎病毒基因组编码一种功能性白细胞介素-4同源物：揭示一种新型毒力因子 |
Volkening, J. D. |
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N/A |
A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: unveiling a novel virulence factor |
| 牙源性和牙周膜间充质中NFATc1+/PDGFR-alpha+细胞的包容性、排他性和层级性图谱 |
Yang, X. |
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N/A |
Inclusive, Exclusive and Hierarchical Atlas of NFATc1+/PDGFR-alpha+ Cells in Dental and Periodontal Mesenchyme |
| 疱疹折叠：一种全蛋白质组结构系统方法揭示了所有九种人类疱疹病毒的蛋白质家族和活性 |
Soh, T. K. |
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N/A |
HerpesFolds: A proteome-wide structural systems approach reveals insights into protein families and activities of all nine human herpesviruses |
| 大规模实验量化淀粉样核形成使得蛋白质聚集的深度学习可解释 |
Thompson, M. |
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N/A |
Massive experimental quantification of amyloid nucleation allows interpretable deep learning of protein aggregation |
| 利用基本再生数量化传播并识别野生动物出血热病毒的数据缺口 |
Gubbins, S. |
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N/A |
Using the basic reproduction ratio to quantify transmission and identify data gaps for epizootic haemorrhagic disease virus |
| 用于深入表征纳米颗粒的流式细胞术程序 |
Tirelli, V. |
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N/A |
FLOW CYTOMETRIC PROCEDURES FOR DEEP CHARACTERIZATION OF NANOPARTICLES |
| 在IAA16中插入的可转座元件破坏了剪接过程，导致Bassia scoparia对草甘膦产生抗性。 |
Montgomery, J. S. |
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N/A |
A transposable element insertion in IAA16 disrupts splicing and causes dicamba resistance in Bassia scoparia |
| 多物种全基因组CRISPR筛选鉴定出冷诱导细胞死亡的保守抑制因子 |
Lam, B. |
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N/A |
Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death |
| 单亲和多倍体胚细胞的起源与发展 |
Zhao, Y. |
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N/A |
Origin and development of uniparental and polyploid blastomeres |
| 双工CeTEAM药物生物传感器揭示了PARP抑制剂选择性的决定因素 |
Pires, M. J. |
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N/A |
Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity |
| 多感官诱发电位用于成功分类遗忘型轻度认知障碍的神经机制 |
Zhang, L. |
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N/A |
Neural Mechanism Underlying Successful Classification of Amnestic Mild Cognitive Impairment Using Multi-Sensory-Evoked Potentials |
| 利用病毒RNA基因组中的功能区域作为可药物作用的靶点 |
Luo, D. |
PDF |
N/A |
Exploiting functional regions in the viral RNA genome as druggable entities |
| 利用病毒RNA基因组中的功能区域作为可药物作用的靶点 |
Luo, D. |
PDF |
N/A |
Exploiting functional regions in the viral RNA genome as druggable entities |
| 在隐球菌中失去RNA干扰后的独特进化轨迹 |
Huang, J. |
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N/A |
Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans |
| OMG数据集：一个用于混合模态基因组语言建模的开源元基因组语料库 |
Cornman, A. |
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N/A |
The OMG dataset: An Open MetaGenomic corpus for mixed-modality genomic language modeling |
| 光微生境中的互利共生关系推动了拟态蝴蝶群落中的感觉趋同 |
Wainwright, J. B. |
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N/A |
Mutualisms within light microhabitats drive sensory convergence in a mimetic butterfly community |
| 动作意识的神经营机制 |
Jin, D. S. |
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N/A |
Neural mechanisms of awareness of action |
| 一个模块化的免疫反应模型作为计算平台，用于研究感染性疾病的发病机制 |
Miroshnichenko, M. |
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N/A |
A modular model of immune response as a computational platform to investigate a pathogenesis of infection disease |
| GM2神经节苷脂病中的质膜重塑驱动突触功能障碍 |
Nicholson, A. S. |
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N/A |
Plasma Membrane Remodelling in GM2 Gangliosidoses Drives Synaptic Dysfunction |
| DeepPWM-BindingNet：结合序列和PWM特征，释放结合预测能力 |
Ali, S. |
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N/A |
DeepPWM-BindingNet: Unleashing Binding Predictionwith Combined Sequence and PWM Features |
| DNA甲基化保护癌细胞免于衰老。 |
Chen, X. |
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N/A |
DNA methylation protects cancer cells against senescence |
| 甲醇趋化受体MtpA和鞭毛蛋白FliC依赖的甲醇趋化性决定了PPFM在叶际中的时空定殖 |
Katayama, S. |
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N/A |
Methanol chemoreceptor MtpA- and flagellin protein FliC-dependent methylotaxis determines the spaciotemporal colonization of PPFM in the phyllosphere |
| 基因内适应性景观上上位性的变异与可预测性。 |
Baheti, S. |
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N/A |
Variations and predictability of epistasis on an intragenic fitness landscape. |
| 使用脂质锚定控制影响外源货物蛋白与细胞外囊泡结合的物理和生化参数，实现高载量和有效的细胞内递送 |
Marquant, A. |
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N/A |
Control of Physical and Biochemical Parameters Influencing Exogeneous Cargo Protein association to Extracellular Vesicle using Lipid Anchors Enables High Loading and Effective Intracellular Delivery |
| 实体瘤局部给药后肿瘤-CAR T细胞相互作用的时空动力学 |
Owens, K. |
PDF |
N/A |
Spatiotemporal dynamics of tumor-CAR T-cell interaction following local administration in solid cancers |
| 棉子糖诱导自噬以促进植物生长 |
Magen, S. |
PDF |
N/A |
Raffinose induces autophagy to promote plant growth |
| SMARTER数据库：一种用于整合绵羊和山羊品种SNP阵列数据集的工具 |
Cozzi, P. |
PDF |
N/A |
SMARTER-database: a tool to integrate SNP arraydatasets for sheep and goat breeds |
| 牙龈卟啉单胞菌外膜囊泡改变了胚胎小鼠大脑中的神经元结构和Tau磷酸化 |
Bradley, A. |
PDF |
N/A |
Porphyromonas gingivalis outer membrane vesicles alter neuronal architecture and Tau phosphorylation in the embryonic mouse brain |
| 蝾螈的表观遗传时钟为揭示极少衰老现象的本质提供了洞见。 |
Haluza, Y. |
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N/A |
Axolotl epigenetic clocks offer insights into the nature of negligible senescence |
| 小脑如何协调运动输出？过去的教训 |
Gilbert, M. |
PDF |
N/A |
How does the cerebellum coordinate motor outputs? Lessons from the past |
| 在注意力短暂调节过程中，跨感觉模式的共享皮层下觉醒系统 |
Khalaf, A. |
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N/A |
Shared subcortical arousal systems across sensory modalities during transient modulation of attention |
| 拟南芥在昼夜和发育时间尺度上的稳定和动态基因表达模式 |
Redmond, E. J. |
PDF |
N/A |
Stable and dynamic gene expression patterns over diurnal and developmental timescales in Arabidopsis thaliana |
| 基于SENP2的α-突触核蛋白N端截断在路易体病理传播中的作用 |
Taguchi, K. |
PDF |
N/A |
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation |
| 基于深度学习的基因扰动效应预测尚未超越简单的线性方法。 |
Ahlmann-Eltze, C. |
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N/A |
Deep learning-based predictions of gene perturbation effects do not yet outperform simple linear methods |
| 聚焦镓离子束的生物体积电子显微镜依赖于在断面形成辐射抗性富镓层 |
Yang, Z. |
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N/A |
Biological volume EM with focused Ga ion beam depends on formation of radiation-resistant Ga-rich layer at block face |
| 高风险神经精神性拷贝数变异与人类脑细胞中趋同的转录组变化相关 |
Dugan, G. |
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N/A |
High-risk neuropsychiatric copy number variants are associated with convergent transcriptomic changes in human brain cells |
| 基于SATAY的化学基因组筛选揭示了抗真菌抗性机制及ATI-2307和壳聚糖敏感性的关键决定因素 |
Karadzas, M. T. |
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N/A |
SATAY-Based Chemogenomic Screening uncovers Antifungal Resistance Mechanisms and Key Determinants of ATI-2307 and Chitosan Sensitivity |
| 通过使用具有均一N-连接糖基的抗原，利用HDX-MS实现糖蛋白的表位分析 |
Ota, T. |
PDF |
N/A |
Enabling Epitope Analysis of Glycoproteins via HDX-MS Using Antigens with Uni-formed N-linked Glycans |
| 持续性的细菌Regiella在鸟樱桃-燕麦蚜虫Rhopalosiphum padi中的转染，增加了宿主的适应性并减少了植物病毒的传播。 |
Yu, W. |
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N/A |
A persistent bacterial Regiella transinfection in the bird cherry-oat aphid Rhopalosiphum padi increasing host fitness and decreasing plant virus transmission |
| 两种特异性纤毛细胞骨架系统在驱动Hedgehog应答转录因子运输中的协同作用 |
Ku, P.-i. |
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N/A |
Collaborative role of two distinct cilium-specific cytoskeletal systems in driving Hedgehog-responsive transcription factor trafficking |
| 慢性淀粉样β寡聚体注射入海马后神经元活动和神经递质释放同时评估的协议 |
Herve, V. |
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N/A |
Protocol for simultaneous evaluation of neuronal activity and neurotransmitter release following chronic amyloid-beta oligomer injections into the hippocampus |
| CLYBL通过修复丙二酰辅酶A，避免了甲基丙二酰辅酶A变位酶的抑制和维生素B12的流失。 |
Griffith, C. M. |
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N/A |
CLYBL averts methylmalonyl-CoA mutase inhibition and loss of vitamin B12 by repairing malyl-CoA |
| 持续注意状态的振荡动力学 |
Solis-Vivanco, R. |
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N/A |
Oscillatory dynamics of sustained attention states |
| 一种用于筛选异构化介导酶药物靶点的差分离子迁移声波喷射质谱系统 |
Bazargan, S. |
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N/A |
A Differential Ion Mobility Acoustic Ejection Mass Spectrometer System for Screening Isomerization-Mediating Enzyme Drug Targets |
| 区间删失对生物高通量筛选中数据准确性和机器学习性能的影响 |
Doffini, V. |
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N/A |
Impact of Interval Censoring on Data Accuracy and Machine Learning Performance in Biological High-Throughput Screening |
| 脊髓投射的5-羟色胺能神经元对活跃运动状态的增强作用 |
Fenstermacher, S. |
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N/A |
Potentiation of active locomotor state by spinal-projecting serotonergic neurons |
| 利用工程化受体实现合成mRNA的胞外配体响应性翻译调控 |
Nakanishi, H. |
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N/A |
Extracellular ligand-responsive translational regulation of synthetic mRNAs using engineered receptors |
| 斑马鱼Pol-Theta和人Pol-Theta，具有同源功能的直系同源物 |
Thomas, C. |
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N/A |
Zebrafish Pol-Theta and Human Pol-Theta, Orthologues with Homologous Function |
| 鉴定药物/代谢物转运蛋白1作为NF54xCam3.II恶性疟原虫遗传杂交中奎宁耐药性的标志物。 |
Kanai, M. |
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N/A |
Identification of the drug/metabolite transporter 1 as a marker of quinine resistance in a NF54xCam3.II P. falciparum genetic cross. |
| 时间变化刺激延长IKK激活促进核重塑和NF-κB动力学的机制转换 |
Smeal, S. W. |
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N/A |
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics |
| 分子与神经回路机制：果蝇性经验依赖的长时记忆 |
Sun, D. |
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N/A |
Molecular and Neural Circuit Mechanisms Underlying Sexual Experience-dependent Long-Term Memory in Drosophila. |
| GoldPolish-目标：定向长读长基因组组装抛光 |
Zhang, E. |
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N/A |
GoldPolish-Target: Targeted long-read genome assembly polishing |
| 中缝背核中的血清素能神经元调控视觉注意力 |
Lehnert, J. |
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N/A |
Serotonergic neurons in the dorsal raphe regulate visual attention |
| 概率模型提高了从基因系统发育中进行相对年代测定的效果。 |
Bernabeu, M. |
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N/A |
Probabilistic modelling improves relative dating from gene phylogenies |
| 隐性致病变异携带者的生殖和认知影响 |
Fridman, H. |
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N/A |
Reproductive and cognitive effects in carriers of recessive pathogenic variants |
| 通过结构学习捕捉代理的最佳和次优行为 |
Moongathottathil James, A. |
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N/A |
Capturing Optimal and Suboptimal behavior Of Agents Via Structure Learning Of Their Internal Model |
| 模块化表征在训练用于执行依赖上下文任务的神经网络中出现 |
Johnston, W. J. |
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N/A |
Modular representations emerge in neural networks trained to perform context-dependent tasks |
| 不规律的光照时间表会导致小鼠的日常节律和基因表达发生改变。 |
Berbegal-Saez, P. |
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N/A |
Irregular light schedules induce alterations on daily rhythms and gene expression in mice |
| 邻近蛋白质组学揭示了一个与中心体相关的LRRK2调控网络的共同进化 |
Eckert, M. |
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N/A |
Proximity proteomics reveals a co-evolved LRRK2-regulatory network linked to centrosomes |
| UBE3A的重新激活恢复了印记缺陷的安格曼综合征小鼠模型中的行为和蛋白质组 |
Milazzo, C. |
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N/A |
UBE3A reinstatement restores behavior and proteome in an Angelman Syndrome mouse model of Imprinting Defects |
| 预测误差的层次结构塑造了依赖于情境的感官表征的学习 |
Tsai, M. C. |
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N/A |
Hierarchy of prediction errors shapes the learning of context-dependent sensory representations |
| 用于在体外模拟大脑皮层发育和顺式调控进化的鼠源类器官平台 |
Medina-Cano, D. |
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N/A |
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro |
| Lgl在有丝分裂退出时重置Par复合物膜加载，以极化神经干细胞 |
LaFoya, B. |
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N/A |
Lgl resets Par complex membrane loading at mitotic exit to polarize neural stem cells |
| 去神经骨骼肌的多模态转录反应涉及胆固醇稳态的改变，影响肌肉大小。 |
Calvo, C. |
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N/A |
The multimodal transcriptional response of denervated skeletal muscle involves alterations in cholesterol homeostasis impacting muscle size |
| 核孔蛋白Nup153将剪接机器锚定在核孔上，以实现高效的mRNA加工。 |
De Castro, I. |
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N/A |
Nucleoporin Nup153 docks the splicing machinery to the nuclear pore for efficient mRNA processing |
| 细胞导航过程中的机械中心体断裂 |
Schmitt, M. T. |
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N/A |
Mechanical Centrosome Fracturing during Cell Navigation |
| 快速无标记活体成像揭示了流体动力学和CD44-HA相互作用在癌细胞滞留于内皮单层中的关键作用 |
Follain, G. |
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N/A |
Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers |
| TET2参与葡萄糖异生并影响2型糖尿病的病理过程。 |
Zhang, X. |
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N/A |
TET2 contributes to gluconeogenesis and pathology of type 2 diabetes |
| 肝窦内皮细胞和层粘连蛋白在慢性肝病中决定胆管细胞的命运 |
Manco, R. |
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N/A |
Liver Sinusoidal Endothelial Cells and Laminin dictate cholangiocytes fate in chronic liver disease |
| 肌动蛋白-肌球蛋白收缩力是人类多能干细胞诱导中胚层形成的有力抑制因素 |
Fort, L. |
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N/A |
Actomyosin Contractility is a Potent Suppressor of Mesoderm Induction by Human Pluripotent Stem Cells |
| 动粒-中心体反馈连接CENP-E和Aurora激酶控制染色体排列 |
Vukusic, K. |
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N/A |
Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression |
| 去泛素化酶Otub2调节胰腺β细胞功能和存活 |
Oshry, M. |
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N/A |
The Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival |
| 肌联蛋白依赖的生物力学反馈使昆虫的肌节适应其特殊的肌肉功能 |
Loreau, V. |
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N/A |
Titin-dependent biomechanical feedback tailors sarcomeres to specialised muscle functions in insects |
| 在海鞘Ciona中，特异性于被囊动物的蛋白质Epi-1对于赋予幼虫被囊亲水性是必不可少的。 |
Kuroiwa, K. |
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N/A |
Tunicate-specific protein Epi-1 is essential for conferring hydrophilicity to the larval tunic in the ascidian Ciona |
| 极体在蜘蛛前后轴形成过程中起到地标作用 |
Wang, R. |
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N/A |
Polar bodies serve as a landmark for anteroposterior axis formation in spiders |
| 分支肌动蛋白聚合驱动侵入性突起的形成，以促进骨骼肌再生过程中肌纤维母细胞的融合。 |
Lu, Y. |
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N/A |
Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during skeletal muscle regeneration |
| 早期合子工程促进靶向性大型转基因整合及全转基因动物的直接生产 |
Gupta, K. |
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N/A |
Early zygotic engineering promotes targeted large transgene integration and direct production of fully transgenic animals |
| 母体高脂高蔗糖饮食引起的过度肥胖与妊娠晚期胎盘缺氧及胎盘免疫稳态紊乱有关。 |
Bellissimo, C. J. |
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N/A |
Maternal high-fat, high-sucrose diet-induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation |
| RO8191是一种用于在小鼠中启动胚胎植入的新化合物。 |
Shu, J. |
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N/A |
RO8191, a new compound for initiating embryoimplantation in mice |
| 胞质增强型基于暗Epac的FRET传感器用于通过FLIM在活细胞中检测细胞内cAMP |
Zanetti, G. |
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N/A |
Cytosolic Enhanced Dark Epac-Based FRET Sensors for Intracellular cAMP detection in live cells via FLIM |
| SC-MAMBA2：利用状态空间模型实现高效单细胞超长转录组建模 |
Zhao, Y. |
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N/A |
SC-MAMBA2: Leveraging State-Space Models for Efficient Single-Cell Ultra-Long Transcriptome Modeling |
| 菊芋提取物调节脂肪酸生物合成中关键酶的基因表达 |
Bunch, H. |
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N/A |
Jerusalem artichoke extracts regulate the gene expression of key enzymes involved in fatty acid biosynthesis |
| 低表达的NOTCH1改变了左心发育不良综合征中心肌细胞的细胞结构 |
Lewis, J. |
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N/A |
Hypomorphic NOTCH1 Expression Alters Cardiomyocyte Cellular Architecture in Hypoplastic Left Heart Syndrome |
| 钙稳态调节剂2在线粒体中构成一个ATP调控孔 |
GUO, Q. |
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N/A |
Calcium Homeostasis Modulator 2 Constitutes an ATP-regulation Pore in Mitochondria |
| S1PR1调节淋巴管瓣膜发育并防止非肠炎依赖的淋巴样器官形成 |
Geng, X. |
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N/A |
S1PR1 Regulates Lymphatic Valve Development And Prevents Ileitis-Independent Tertiary Lymphoid Organ Formation |
| 在拟南芥中，PRESSED FLOWER 通过下游作用于 ASYMMETRIC LEAVES 2 来影响萼片的扁平度。 |
Liu, R. |
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N/A |
PRESSED FLOWER works downstream of ASYMMETRIC LEAVES 2 to affect sepal flatness in Arabidopsis |
| 量化生化途径中的癌症药物靶向性 |
Hagler, S. |
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N/A |
Quantifying Cancer Drug Targetability across Biochemical Pathways |
| 细菌中脉冲基础基因表达作为适应性决定因素 |
Jain, K. |
PDF |
N/A |
Pulsatile basal gene expression as a fitness determinant in bacteria |
| 可解释人工智能在MRI分析中的应用：将模型预测与老化大脑的神经影像特征相关联 |
Hofmann, S. M. |
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N/A |
The utility of explainable A.I. for MRI analysis: Relating model predictions to neuroimaging features of the aging brain |
| 对具有广谱抗病毒能力的木薯（Manihot esculenta）品系COL40进行单倍体型解析组装，揭示了位于12号染色体上含有大量重复元件的区域，这些病毒是导致木薯褐条病的原因。 |
Thoben, C. |
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N/A |
The haplotype-resolved assembly of COL40 a cassava (Manihot esculenta) line with broad-spectrum resistance against viruses causing Cassava brown streak disease unveils a region of highly repeated elements on chromosome 12 |
| 使用张量分解的AI驱动计算方法可以在整合多个Hi-C数据集时发现共同的优化bin大小。 |
Taguchi, Y.-h. |
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N/A |
Novel AI-powered computational method using tensor decomposition can discover the common optimal bin sizes when integrating multiple Hi-C datasets |
| 基于mRNA的RSV preF疫苗在临床前研究中的疗效和安全性 |
bai, h. |
PDF |
N/A |
Efficacy and safety of an mRNA-based RSV preF vaccine in preclinical studies |
| 温带森林林下草本植物和禾草类植物对干旱胁迫的形态和生理反应比较 |
Petek-Petrik, A. |
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N/A |
Comparison of morphological and physiological response to drought stress among temperate forest understory forbs and graminoids |
| IQD2招募KLCR1到膜-微管连接处，促进叶表皮铺路细胞的细胞骨架力学响应性 |
Buhl, J. |
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N/A |
IQD2 recruits KLCR1 to the membrane-microtubule nexus to promote cytoskeletal mechano-responsiveness in leaf epidermis pavement cells |
| 植物免疫受体广谱识别病原效应蛋白的定向进化 |
Rim, E. Y. |
PDF |
N/A |
Directed evolution of a plant immune receptor for broad spectrum recognition of pathogen effectors |
| 墨西哥酸橙基因组二倍体组装揭示了广泛的杂合性 |
Leichty, A. |
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N/A |
Diploid assembly of the Mexican lime genome reveals extensive heterozygosity |
| 叶片气腔中的不饱和与近似同位素均质性 |
Collaviti, S. E. |
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N/A |
Unsaturation and Approximate Isotopic Homogeneity in Leaf Air Spaces |
| 自闭症患者在观察触摸时的动态功能适应：连接强度与对社交触摸的态度和社会反应性有关 |
Masson, H. L. |
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N/A |
Dynamic functional adaptations during touch observation in autism: Connectivity strength is linked to attitudes towards social touch and social responsiveness |
| 多种转录因子调控阿氏肠杆菌中易错DNA聚合酶基因的表达 |
Nguyen, B. H. |
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N/A |
Multiple transcription factors regulate the expression of genes for error prone DNA polymerases in Acinetobacter baumannii |
| 群体感应和DNA甲基化在临床伯克霍尔德菌的相变中起着积极作用。 |
Coulon, P. M. L. . |
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N/A |
Quorum sensing and DNA methylation play active roles in clinical Burkholderia phase variation |
| 双单倍体溪红点鲑（Salvelinus fontinalis）的染色体水平基因组组装 |
Lecomte, L. |
PDF |
N/A |
Chromosome-level genome assembly of a doubled haploid brook trout (Salvelinus fontinalis) |
| 一种用于缓解晕车的可穿戴正念脑机接口 |
Zhu, J. |
PDF |
N/A |
A Wearable Mindfulness Brain-Computer Interface for Alleviating Car Sickness |
| 针对嗅觉受体可通过肌动蛋白细胞骨架解聚减轻高残余血小板反应性和动脉血栓形成 |
Aggarwal, A. |
PDF |
N/A |
Targeting an Olfactory Receptor Mitigates High Residual Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Depolymerization |
| 特定种子特异性过表达改良的小麦Or基因可提高水稻和小麦籽粒中的β-胡萝卜素含量。 |
Sirohi, P. |
PDF |
N/A |
Seed specific overexpression of a modified wheat Or gene leads to enhanced β-carotene in rice and wheat grains |
| 数据猎人：连接生物信息学教育和微生物组研究 |
Fumagalli, S. |
PDF |
N/A |
Data Hunters: bridging bioinformatics education and microbiome research |
| 通过完全自主的HABITS系统实现新颖且优化的鼠标行为：家庭笼辅助行为创新与测试系统 |
Yu, B. |
PDF |
N/A |
Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage Assisted Behavioral Innovation and Testing System |
| 一个模仿大肠杆菌膜生物物理特性的极简模型脂质系统 |
Tormena, N. |
PDF |
N/A |
A minimalist model lipid system mimicking the biophysical properties of Escherichia coli membrane |
| R405W desmin敲入小鼠的综合数据显示，肌纤维病初期阶段线粒体功能、蛋白质质量控制和肌纤维结构的改变。 |
Batonnet-Pichon, S. |
PDF |
N/A |
Integrated data from R405W desmin knock-in mice highlight alterations of mitochondrial function, protein quality control, and myofibrillar structure in the initial stages of myofibrillar myopathy |
| 宿主树木叶片对昆虫病原体多态性的影响 |
Freedman, A. S. |
PDF |
N/A |
Effects of Host-Tree Foliage on Polymorphism in an Insect Pathogen |
| 宿主树木叶片对昆虫病原体多态性的影响 |
Freedman, A. S. |
PDF |
N/A |
Effects of Host-Tree Foliage on Polymorphism in an Insect Pathogen |
| 流体流动影响血管炎症纤维化模型中的内皮细胞-单核细胞相互作用 |
Linares, I. |
PDF |
N/A |
Fluid Flow Impacts Endothelial-Monocyte Interactions in a Model of Vascular Inflammatory Fibrosis |
| STIX：基于长读长测序的群体规模结构变异精准注释 |
Zheng, X. |
PDF |
N/A |
STIX: Long-reads based Accurate Structural Variation Annotation at Population Scale |
| 以患者为中心的知识图谱方法，用于优先筛选突变体以进行选择性抗癌靶向治疗 |
Gorostiola Gonzalez, M. |
PDF |
N/A |
A patient-centric knowledge graph approach to prioritize mutants for selective anti-cancer targeting |
| 负责胸腺功能的基本相互作用解释了复杂的髓质形状 |
Muramatsu, D. |
PDF |
N/A |
Basic interactions responsible for thymus function explain convoluted medulla shape |
| 从遗传学定义的小鼠肝母细胞瘤中高效衍生出永生化、同基因细胞系 |
Wang, H. |
PDF |
N/A |
Efficient Derivation of Immortalized, Isogenic Cell Lines from Genetically Defined Murine Hepatoblastomas |
| 早期青少年期第二代抗精神病药物暴露对体重、热量摄入及代谢相关基因表达的长期影响 |
Soto, P. |
PDF |
N/A |
Long-Term Effects of Early Adolescent Second-Generation Antipsychotic Exposure on Body Weight, Caloric Intake, and Metabolism-Associated Gene Expression |
| 吞噬作用通过PGE2的形成和EP4信号在M1型和M2型巨噬细胞中受到LPS的不同调控。 |
Kirchhoff, R. |
PDF |
N/A |
Phagocytosis is differentially regulated by LPS in M1- and M2-like macrophages via PGE2 formation and EP4 signaling |
| 印度东部喜马拉雅季节性热带森林中的叶、花和果实物候模式及其与环境的关系 |
Datta, A. |
PDF |
N/A |
Patterns of leaf, flower and fruit phenology and environmental relationships in a seasonal tropical forest in the Indian Eastern Himalaya |
| 药用植物对南方根结线虫（Meloidogyne javanica）的植物化学分析和杀线虫活性研究 |
Maher, S. |
PDF |
N/A |
Phytochemical Analysis and Nematicidal Activity of Medicinal Plants Against Meloidogyne javanica |
| 配体结合对人类内皮细胞中VEGFR1、VEGFR2和NRP1定位的影响 |
Sarabipour, S. |
PDF |
N/A |
Impact of ligand binding on VEGFR1, VEGFR2, and NRP1 localization in human endothelial cells |
| 成年雄性大鼠扣带区（下边缘区和前扣带区，背侧部分）与间脑（间脑）之间的双向连接的地形组织 |
Negishi, K. |
PDF |
N/A |
Topographic organization of bidirectional connections between the cingulate region (infralimbic area and anterior cingulate area, dorsal part) and the interbrain (diencephalon) of the adult male rat |
| 环境无关物体识别的硬连线视觉滤波器 |
Kang, M. |
PDF |
N/A |
Hard-wired visual filters for environment-agnostic object recognition |
| 生理因素对静息态和任务态功能连接影响的调查 |
Askarinejad, S. E. |
PDF |
N/A |
Investigation of the effect of physiological factors on resting-state and task-based functional connectivity |
| 淀粉样β病理加速了5xFAD小鼠视觉通路的改变 |
McCool, S. |
PDF |
N/A |
Amyloid Beta Pathology Accelerates Alterations in the Visual Pathway of the 5xFAD Mouse |
| 复杂运动轨迹由蝗虫中多个运动敏感的下行中间神经元的总体活动所形成的人口编码来表示。 |
Zhang, S. |
PDF |
N/A |
Complex motion trajectories are represented by a population code from the ensemble activity of multiple motion-sensitive descending interneurons in locusts |
| 使用鼠尾草酸治疗可减轻IL-33激活后促炎性肥大细胞介质的分泌 |
Crozier, R. W. E. |
PDF |
N/A |
Treatment with carnosic acid attenuates the secretion of pro-inflammatory mast cell mediators following IL-33 activation |
| 在赫拉克勒斯蚁中，节俭的超个体表型作为一种可塑性反应，出现在极端环境中。 |
Plante, E. |
PDF |
N/A |
Thrifty superorganism phenotypes emerge as a plastic response to extreme environments in the Hercules ant |
| 珊瑚礁修复的人口基因组学——密克罗尼西亚鹿角珊瑚的案例研究 |
Rios, D. |
PDF |
N/A |
Population genomics for coral reef restoration - a case study of staghorn corals in Micronesia |
| 加拉帕戈斯群岛Scalesia适应性辐射中的基因组稳定性：尽管存在杂交和生态位转变，转座元件的积累依然一致 |
Cerca, J. |
PDF |
N/A |
Genomic stability in the Galapagos Scalesia adaptive radiation: Consistent transposable element accumulation despite hybridization and ecological niche shifts |
| 在果蝇中，心脏性能的衰老自然变化揭示了PAR域bZIP转录因子Pdp1/dHLF在心脏衰老中的核心功能 |
Audouin, K. |
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N/A |
Natural variations of aging of cardiac performance in Drosophila identifies a central function for the PAR domain bZIP transcription factor Pdp1/dHLF in cardiac senescence |
| 巨大的染色体外元素“Inocle”可能潜在地扩展了人类口腔微生物群的适应能力 |
Kiguchi, Y. |
PDF |
N/A |
Giant extrachromosomal element "Inocle" potentially expands the adaptive capacity of the human oral microbiome |
| GeTMoR：同时进行基因组、转录组和形态学的稀有单细胞分析 |
Prabakar, R. K. |
PDF |
N/A |
GeTMoR: Simultaneous genomic, transcriptomic, andmorphological profiling of rare single cells |
| 在小鼠中对可口糖的暴饮暴食进行情境增强 |
Matsui, H. |
PDF |
N/A |
Contextual enhancement on binge-like overconsumption of palatable sugar in mice |
| 迭代牺牲三维打印与聚合物铸造技术用于制造复杂血管移植物及多腔室生物人工器官 |
Brassard, J. A. |
PDF |
N/A |
Iterative sacrificial 3D printing and polymer casting to create complex vascular grafts and multi-compartment bioartificial organs |
| 电阻抗光谱作为一种检测前列腺癌细胞上皮间质转化的工具 |
Crowell, L. L. |
PDF |
N/A |
Electrical Impedance Spectroscopy as a Tool to Detect the Epithelial to Mesenchymal Transition in Prostate Cancer Cells |
| 一种新型工程化U7小核RNA支架在体外和体内显著增加了ADAR介导的可编程RNA碱基编辑 |
Byrne, S. M. |
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N/A |
A Novel Engineered U7 Small Nuclear RNA Scaffold Greatly Increases in vitro and in vivo ADAR-Mediated Programmable RNA Base Editing |
| 一种新型工程化U7小核RNA支架在体外和体内显著增强了ADAR介导的可编程RNA碱基编辑 |
Byrne, S. M. |
PDF |
N/A |
A Novel Engineered U7 Small Nuclear RNA Scaffold Greatly Increases in vitro and in vivo ADAR-Mediated Programmable RNA Base Editing |
| PlasmidGPT：一个用于质粒设计和注释的生成框架 |
SHAO, B. |
PDF |
N/A |
PlasmidGPT: a generative framework for plasmid design and annotation |
| 公民科学家在远足期间未检测到的现象，可以建模为天气、季节、清单长度和个人偏好的函数。 |
Jacobusse, G. W. |
PDF |
N/A |
Non-detection during excursions by citizen scientists modeled as a function of weather, season, list length, and individual preferences |
| 解锁低质量总RNA-seq数据的潜力：一种逐步映射方法以改进定量分析 |
Lee, J. |
PDF |
N/A |
Unlocking the Potential of Low Quality Total RNA-seq Data: A Stepwise Mapping Approach for Improved Quantitative Analyses |
| Eps15 EH结构域与内在无序蛋白质之间的竞争性相互作用形成了一个复杂的相互作用网络。 |
Papagiannoula, A. |
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N/A |
Competitive interactions between Eps15 EH domains and intrinsically disordered proteins generate a complex interaction network |
| 弹簧加载的DNA折纸阵列作为模块化纳米机器人的能量供应硬件 |
Pfeiffer, M. |
PDF |
N/A |
Spring-loaded DNA origami arrays as energy-supplied hardware for modular nanorobots |
| 非整倍体上位性图谱揭示了与癌症中多余染色体相关的代谢脆弱性 |
Magesh, R. Y. |
PDF |
N/A |
An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer |
| 基于深度学习的母体心电图推断子宫收缩 |
Tanaka, S. |
PDF |
N/A |
Deep Learning-Based Inference of Uterine Contractions from Maternal ECG |
| BMP信号调节控制原条的形成 |
Simon, G. |
PDF |
N/A |
BMP signaling modulations control primitive streak patterning |
| 鸣禽红眉金丝雀（Neochmia temporalis temporalis）中非典型精子形态的独立进化 |
Rowe, M. |
PDF |
N/A |
Independent evolution of atypical sperm morphology in a passerine bird, the red-browed finch (Neochmia temporalis temporalis) |
| 在平均任务中，观察结果的不精确计数预测了首因效应和近因效应 |
Prat-Carrabin, A. |
PDF |
N/A |
Imprecise counting of observations in averaging tasks predicts primacy and recency effects |
| 探索无偿献血者中红细胞参数与血小板指数之间的关联 |
De, R. |
PDF |
N/A |
Exploring the link between extended red blood cell parameters and platelet indices in voluntary blood donors |
| 层粘连蛋白调控核力学与形态，以控制胶质母细胞瘤细胞的增殖、迁移和侵袭。 |
Wang, X. |
PDF |
N/A |
Lamins regulate nuclear mechanics and shape to control glioblastoma cell proliferation, migration and invasion |
| 多模态大语言模型实现药物机制和性质的全方位预测 |
Liang, Y. |
PDF |
N/A |
Multi-Modal Large Language Model Enables All-Purpose Prediction of Drug Mechanisms and Properties |
| 首次完成昆虫眼睛的三维重建与形态功能图谱绘制 |
Makarova, A. A. |
PDF |
N/A |
The first complete 3D reconstruction and morphofunctional mapping of an insect eye |
| 电磁刺激微丝化水凝胶用于引导神经元形态发生 |
Jensen, B. N. |
PDF |
N/A |
Electromagnetic Stimulated Microfillamented Hydrogels for Guided Neuronal Morphogenesis |
| 通过将EM算法应用于改进的广义线性模型，将生物学变异与噪声分离 |
Lee, T.-W. |
PDF |
N/A |
Separating biological variance from noise by applying EM algorithm to modified General Linear Model |
| 利用bond-boost超动力学方法研究蛋白质路径的加速分子动力学研究 |
Park, S. W. |
PDF |
N/A |
An accelerated molecular dynamics study for investigating protein pathways using the bond-boost hyperdynamics method |
| 巨核细胞构建了一个细胞外基质笼，控制其成熟和锚定于血管壁龛。 |
Masson, C. |
PDF |
N/A |
Megakaryocytes build a cage of extracellular matrix that controls their maturation and anchoring to the vascular niche |
| 维持神经元中TDP-43的表达需要轴突溶酶体的运输 |
Ryan, V. H. |
PDF |
N/A |
Maintenance of neuronal TDP-43 expression requires axonal lysosome transport |
| 调节秀丽隐杆线虫进入持久化状态决策的神经元活动 |
Prakash, S. J. |
PDF |
N/A |
Neuronal activity regulating the dauer entry decision in Caenorhabditis elegans |
| 在实时fMRI神经反馈中引入触觉反馈：一种调节初级运动皮层活动的新方法 |
Fleury, M. |
PDF |
N/A |
Introducing Haptic Feedback in Real-Time fMRI Neurofeedback: A Novel Approach to Modulate Primary Motor Cortex Activity |
| 鉴定与中国仓鼠卵巢（CHO）细胞适应性相关的细胞特征，以分泌抗体 |
Bai, Y. |
PDF |
N/A |
Identification of Cellular Signatures Associated with Chinese Hamster Ovary (CHO) Cell Adaptation for Secretion of Antibodies |
| UniGEN-DDI：利用统一图嵌入网络计算药物-药物相互作用 |
Mondal, S. |
PDF |
N/A |
UniGEN-DDI: Computing drug-drug interactions using a unified graph embedding network |
| 人类Toll样受体中的亮氨酸重复结构域中个体差异的重复出现解释了它们的多样性和功能适应性。 |
Takkouche, A. |
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N/A |
Divergence of the Individual repeats in the leucine-rich repeat domains of human Toll-like receptors explain their diversity and functional adaptations. |
| RAPDOR：利用Jensen-Shannon距离进行复杂蛋白质组学数据集的计算分析 |
Hemm, L. |
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N/A |
RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics datasets |
| 武士：使用可重复且集成的生物信息学管道对拷贝数变异进行浅层分析 |
Potente, S. |
PDF |
N/A |
SAMURAI: Shallow Analysis of Copy nuMber alterations Using a Reproducible And Integrated bioinformatics pipeline |
| 捕捉哺乳动物细胞的层次分类蛋白质相互作用模块 |
Dai, S. |
PDF |
N/A |
Capturing the Hierarchically Assorted Protein-protein Interaction Modules of Mammalian Cell |
| 锌离子介导的胱天蛋白酶-3非竞争性抑制的计算分析 |
Tian, X. E. |
PDF |
N/A |
Computational Analysis of Zn2+ Mediated Non-Competitive Inhibition to Caspase-3 |
| GPCR结构域与功能的关系：受体螺旋束和C端对GRK特异性功能和β-arrestin介导的调控有不同的影响 |
Matthees, E. S. |
PDF |
N/A |
Relating GPCR domains with functionality: receptor helix-bundle and C-terminus differentially influence GRK-specific functions and β-arrestin-mediated regulation |
| 基准测试用于后扰动RNAseq预测的基础细胞模型 |
Csendes, G. |
PDF |
N/A |
Benchmarking a foundational cell model for post-perturbation RNAseq prediction |
| 溶质载体超家族互作网络 |
Frommelt, F. |
PDF |
N/A |
The solute carrier superfamily interactome |
| VPS35(D620N)敲入小鼠中出现的谷氨酸和多巴胺功能障碍及LRRK2抑制剂的快速逆转 |
Kamesh, A. |
PDF |
N/A |
Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition |
| 心理努力和反事实情境对语言理解的影响：老年人ERP证据 |
Salas-Herrera, J. L. |
PDF |
N/A |
Mental Effort and Counterfactuals Modulate Language Understanding: ERP Evidence in Older Adults |
| 一种无需使用仿真体即可实现PET图像空间分辨率校正的新方法 |
Carbonell, F. |
PDF |
N/A |
A novel method for harmonization of PET image spatial resolution without phantoms |
| 将显微镜与扩散磁共振成像通过退化的生物物理模型相连接：贝叶斯变化估计（BENCH）框架的应用 |
Kor, D. Z. L. |
PDF |
N/A |
Linking microscopy to diffusion MRI with degenerate biophysical models: an application of the Bayesian EstimatioN of CHange (BENCH) framework |
| tau病变的分类揭示了原丝核心残基的作用。 |
Vaquer-Alicea, J. |
PDF |
N/A |
Functional classification of tauopathy strains reveals the role of protofilament core residues. |
| 奇怪的异常反应反映了小鼠初级视觉皮层中复杂且依赖于情境的预期 |
Knudstrup, S. G. |
PDF |
N/A |
Oddball evoked deviant responses reflect complex context dependent expectations in mouse V1 |
| CXXC指蛋白1与FOXP3相互作用，以稳定调节性T细胞的稳态和抑制功能 |
Meng, X. |
PDF |
N/A |
CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells |
| 改变游戏规则的突变 |
Edhan, O. |
PDF |
N/A |
Game Changing Mutation |
| 甲基组揭示了两种植物物种群体中最近的进化变化 |
Korfmann, K. |
PDF |
N/A |
Methylomes reveal recent evolutionary changes in populations of two plant species |
| 脂肪组织中瘦素上游增强子表观遗传修饰的性别特异性作用 |
Mueller, L. |
PDF |
N/A |
Sex-specific role of epigenetic modification of a leptin upstream enhancer in the adipose tissue |
| 基因组关联研究的谱系蒸馏 |
Christ, R. |
PDF |
N/A |
Clade Distillation for Genome-wide Association Studies |
| 现场采集的蜱虫中存在Powassan病毒缺失和缺陷RNA的证据 |
Langsjoen, R. M. |
PDF |
N/A |
Evidence for Powassan virus deletions and defective RNA in field collected ticks |
| 通过动态结构学习推断代理的时间变化内部模型 |
Moongathottathil James, A. |
PDF |
N/A |
Inferring Time-Varying Internal Models of Agents Through Dynamic Structure Learning |
| 同位素标记在MaxQuant中的更新 |
Ferretti, D. |
PDF |
N/A |
Isobaric labeling update in MaxQuant |
| 在成像质谱数据降维中保留全光谱信息 |
Moens, R. A. R. |
PDF |
N/A |
Preserving Full Spectrum Information in ImagingMass Spectrometry Data Reduction |
| BindCraft：功能性蛋白质结合剂的一步设计 |
Pacesa, M. |
PDF |
N/A |
BindCraft: one-shot design of functional protein binders |
| 瞬时蛋白质结构指导膜超复合物中电子传递的表面扩散路径 |
Chan, C. K. |
PDF |
N/A |
Transient protein structure guides surface diffusion pathways for electron transport in membrane supercomplexes |
| 在唐氏综合症B细胞急性淋巴母细胞白血病中，可以通过使用Venetoclax靶向代谢脆弱性。 |
Jones, D. |
PDF |
N/A |
Metabolic vulnerabilities in Down syndrome B-cell acute lymphoblastic leukemia can be targeted using Venetoclax |
| 脑转移中三级淋巴结构的鉴定与特征分析 |
Mughal, S. S. |
PDF |
N/A |
Identification and characterization of tertiary lymphoid structures in brain metastases |
| 使用性别特异性的心脏模拟器实时预测药物引起的致心律失常风险 |
Dominguez-Gomez, P. |
PDF |
N/A |
Real-time prediction of drug-induced proarrhythmic risk with sex-specific cardiac emulators |
| 草酸钙结石形成者的酸排泄受损 |
Silva, P. H. I. |
PDF |
N/A |
Acid excretion is impaired in calcium oxalate stone formers |
| 陆地植物免疫稳态模块的保守性 |
Dou, R. |
PDF |
N/A |
Conservation of an immune homeostasis module in land plants |
| 小型化实验室设备作为在基础设施有限的西非国家实施保护遗传学工具和教育的解决方案：以几内亚比绍非法野生动物贸易研究为例 |
da Silva, M. J. F. |
PDF |
N/A |
Miniaturised laboratorial equipment as a solution to implement conservation genetics tools and education in West African countries with limited infrastructures: an application to the study of illegal wildlife trade in Guinea-Bissau |
| 9.4 T下人脑中代谢物和大分子的定量二维J分辨代谢物循环半LASER光谱学 |
Murali-Manohar, S. |
PDF |
N/A |
Quantitative 2D J-resolved metabolite-cycled semiLASER spectroscopy of metabolites and macromolecules in the human brain at 9.4 T |
| 基于生物学的芯片上脑模型识别出在高度兴奋的神经网络中选择性的地形重组 |
Poinsot, M. |
PDF |
N/A |
Biologically grounded brain-on-chip model identifies selective topographic reorganization within hyperexcitable neural networks |
| 多巴胺活动在条件性味觉厌恶范式中编码同一刺激的情感变化 |
Loh, M. |
PDF |
N/A |
Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms |
| 亲社会行为的可分离后效：努力对他人的代价高，但对自己有价值 |
Zheng, Y. |
PDF |
N/A |
Dissociable after-effects of prosocial acts: Effort is costly for others but valued for self |
| 独特的表达谱揭示了三叉神经系统中胶质细胞的参与，这与创伤后头痛有关。 |
Nagarajan, G. |
PDF |
N/A |
Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache |
| 传粉者是否在塑造花蜜中必需氨基酸方面发挥作用？ |
Parkinson, R. H. |
PDF |
N/A |
Do pollinators play a role in shaping the essential amino acids found in nectar? |
| 检测金黄色葡萄球菌核心基因组中推动抗生素抗性的正向选择 |
Rimmer, C. O. |
PDF |
N/A |
Detection of positive selection driving antimicrobial resistance in the core genome of Staphylococcus epidermidis |
| 具备开发人类基因组标准E701的经验 |
Vasiliadis, I. |
PDF |
N/A |
Experience in developing the human genome standard E701 |
| scGNN+：将ChatGPT适配于无缝教程与代码优化 |
Jiang, Y. |
PDF |
N/A |
scGNN+: Adapting ChatGPT for Seamless Tutorial and Code Optimization |
| 小鼠前列腺腺体中的核苷酸酶和嘌呤能受体 |
Yu, J. |
PDF |
N/A |
Ectonucleotidases and Purinergic Receptors in Mouse Prostate Gland |
| CalTrig：一种基于图形用户界面的机器学习方法，用于解码自由活动啮齿动物中的神经元钙瞬变 |
Lange, M. A. |
PDF |
N/A |
CalTrig: A GUI-Based Machine Learning Approach for Decoding Neuronal Calcium Transients in Freely Moving Rodents |
| 通过罗望子果实乙醇提取物改善氟化钠处理的大鼠氧化应激 |
Usman, L. A. |
PDF |
N/A |
Amelioration of Oxidative Stress in Sodium Fluoride-administered Wistar Rats by Tamarindus indica Fruit Pulp Ethanolic Extract |
| 利用分子模拟和机器学习辅助的CDR移植技术设计靶向SARS-CoV-2刺突糖蛋白的纳米抗体 |
Ferraz, M. V. F. |
PDF |
N/A |
Design of nanobody targeting SARS-CoV-2 spike glycoprotein using CDR-grafting assisted by molecular simulation and machine learning |
| 多样化的、微型化的和祖先的部件用于哺乳动物基因组工程和分子记录 |
McDiarmid, T. A. |
PDF |
N/A |
Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording |
| Cxcl10在小鼠SARS-CoV-2感染期间对生存至关重要 |
Majumdar, S. |
PDF |
N/A |
Cxcl10 is required for survival during SARS-CoV-2 infection in mice |
| 一个独特的细菌家族再次出击！ |
Shukla, G. |
PDF |
N/A |
A unique bacterial family strikes again! |
| 隐孢子虫微粒体中替代性电子传递链的功能 |
Deng, S. |
PDF |
N/A |
Function of the alternative electron transport chain in the Cryptosporidium parvum mitosome |
| MutRS群体感应系统控制人类病原体变异链球菌中的细菌素变菌素生产。 |
Wyllie, R. M. |
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N/A |
The MutRS quorum sensing system controls lantibiotic mutacin production in the human pathogen Streptococcus mutans |
| 克鲁兹锥虫细胞图谱；理解寄生虫种群异质性和分化的单细胞资源。 |
Laidlaw, R. |
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N/A |
The Trypanosoma cruzi cell atlas; a single-cell resource for understanding parasite population heterogeneity and differentiation. |
| 临床收集的细菌性阴道病诊断样本中阴道微生物群的特征分析 |
Brochu, H. N. |
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N/A |
Characterization of vaginal microbiomes in clinician-collected bacterial vaginosis diagnosed samples |
| 从rocaglates/aglains库筛选中体外发现手足口病的治疗先导 |
Oo, A. |
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N/A |
In vitro discovery of a therapeutic lead for HFMD from a library screen of rocaglates/aglains |
| PfPPM2信号传导调控人类疟原虫恶性疟原虫的无性分裂和有性转换 |
Rawat, A. |
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N/A |
PfPPM2 signalling regulates asexual division and sexual conversion of human malaria parasite Plasmodium falciparum |
| B组链球菌通过裂解内皮细胞感染大脑，在斑马鱼脑膜炎模型中 |
Ravishankar, S. |
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N/A |
Group B streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model |
| 替考拉宁在体外可减轻RNA病毒感染 |
Espano, E. |
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N/A |
Teicoplanin attenuates RNA virus infection in vitro |
| 依赖于Rho的终止和RNase E介导的切割：多顺反子mRNA 3'端加工的双重途径 |
Jeon, H. J. |
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N/A |
Rho-dependent termination and RNase E-mediated cleavage: Dual pathways for RNA 3' end processing in polycistronic mRNA |
| 一种新型重组聚羟基丁酸（PHB）生产平台，在丝状蓝藻中避免氮饥饿的同时保持细胞活力 |
Fink, P. |
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N/A |
A novel recombinant PHB production platform in filamentous cyanobacteria avoiding nitrogen starvation while preserving cell viability |
| 骨细胞树突中mRNA的转运与翻译 |
Mazur, C. M. |
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N/A |
Trafficking and translation of mRNA in osteocyte dendrites |
| 晚年短期饮食限制改善了肠道干细胞功能，并影响了肠道干细胞的DNA甲基化。 |
Kurup, K. |
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N/A |
Late-life short-term dietary restriction ameliorates intestinal stem cell function and impacts intestinal stem cell DNA methylation |
| 可扩展制造用于自动化室温X射线蛋白质晶体学的阵列型固定靶装置 |
Saha, S. |
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N/A |
Scalable Fabrication of an Array-Type Fixed-Target Device for Automated Room Temperature X-ray Protein Crystallography |
| 长角甲虫利用磷酸钙生物矿物形成结构色 |
Chang, Y. |
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N/A |
Longhorn Beetles form Structural Colour Using Calcium Phosphate Biominerals |
| 利用计算机模拟和表征爱泼斯坦-巴尔病毒的LMP1蛋白 |
Abdul Salam, D. S. |
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N/A |
In silico modelling and characterization of Epstein Barr virus LMP1 protein |
| HRS的二维凝聚体驱动扁平网格蛋白笼在内涵体上的组装 |
Hakala, M. |
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N/A |
Two-dimensional condensates of HRS drive the assembly of flat clathrin lattices on endosomes |
| 开发高效且选择性的CK1α分子胶降解剂 |
Geng, Q. |
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N/A |
Development of potent and selective CK1α Molecular Glue Degraders |
| 计算人类相互作用组 |
Zhang, J. |
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N/A |
Computing the Human Interactome |
| 塑造哺乳动物PRPS酶复合体的进化起源与创新 |
Karki, B. |
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N/A |
Evolutionary origins and innovations sculpting the mammalian PRPS enzyme complex |
| 一种具有共同参考框架的分子表示系统，用于天然产物途径发现和结构多样性任务。 |
Babineau, N. |
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N/A |
A molecular representation system with a common reference frame for natural products pathway discovery and structural diversity tasks. |
| 新世界哺乳动物沙粒病毒刺突复合物抗原糖蛋白构建块的结构与稳定化 |
Paesen, G. C. |
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N/A |
Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex |
| c-di-GMP效应蛋白FleQ通过抑制Azotobacter vinelandii中algD基因的转录来控制海藻酸盐的产生。 |
BARRIOS-RAFAEL, V. V. |
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N/A |
The c-di-GMP effector FleQ controls alginate production by repressing transcription of the algD gene in Azotobacter vinelandii |
| 肺炎球菌素B是一种链球菌素B，作为早期感受态级联反应的一部分产生，并促进种内竞争。 |
Richardson, J. D. |
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N/A |
The pneumococcal bacteriocin streptococcin B is produced as part of the early competence cascade and promotes intraspecies competition. |
| 来自阴沟肠杆菌的一种岩藻糖结合超凝集素，具有高度的Lewis和ABO血型抗原特异性。 |
Beshr, G. |
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N/A |
A fucose-binding superlectin from Enterobacter cloacae with high Lewis and ABO blood group antigen specificity |
| 多组学分析揭示了BnC07MYB3a在甘蓝型油菜种皮颜色中的作用机制。 |
Hu, R. |
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Multi-omics analysis reveals the mechanism of BnC07MYB3a is involved in seed coat color in Brassica napus L. |
| CK1α、FAM83H和FAM83B参与神经丝的捆绑，并在ARSACS的细胞和小鼠模型中被隔离。 |
Atkinson, C. S. |
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N/A |
CK1α, FAM83H, and FAM83B contribute to bundling of neurofilaments and are sequestered in cellular and mice models of ARSACS |
| 细胞色素c在人类卵母细胞线粒体代谢中的作用 |
Surmacki, J. M. |
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N/A |
The role of cytochrome c in mitochondrial metabolism of human oocytes |
| 使用可解释的机器学习理解TCR T细胞敲除行为 |
Blennemann, M. |
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N/A |
Understanding TCR T cell knockout behavior using interpretable machine learning |
| THEMIS的CABIT2结构域的结构揭示了一种新型蛋白质折叠，其中插入了一个类似SH3的结构域 |
Beyett, T. S. |
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N/A |
Structure of the CABIT2 domain of THEMIS reveals a novel protein fold with an inserted SH3-like domain |
| 超分辨率轴向成像用于量化活细胞中的皮牛顿牵引力 |
Wang, D.-X. |
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N/A |
Super-Resolution Axial Imaging for Quantifying Piconewton Traction Forces in Live-cells |
| 从头设计与萘二酰亚胺结合的蛋白质，萘二酰亚胺是一种具有可调光物理性质的强效光氧化剂 |
Mann, S. I. |
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N/A |
De novo design of proteins that bind naphthalenediimides, powerful photooxidants with tunable photophysical properties |
| 通过信息瓶颈，褶皱的睫状丛在无神经动物中塑造了展开动力学 |
Brannon, C. M. |
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N/A |
Creased ciliary flocks shape unfolding dynamics via information bottlenecks in an aneural animal |
| 超声机械基因肿瘤预处理联合SynNotch CAR-T疗法 |
Yoon, C. W. |
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N/A |
Tumor Priming by Ultrasound Mechanogenetics for with SynNotch CAR T Therapy |
| 水杨酸、过氧化氢酶2和AtSAP5的精细调节激发植物免疫 |
Chang, L. |
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N/A |
Delicate tuning of H2O2 by salicylic acid, catalase 2, and AtSAP5 incites plant immunity |
| 德克萨斯A&M国际大学两个不同干扰水平地点的节肢动物多样性 |
Siller, E. |
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N/A |
Arthropod Diversity at Two Sites with Different Disturbance Levels at the Texas A&M International University |
| 植物SCAR/WAVE功能分化的分子基础 |
Brumm, S. |
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N/A |
A molecular basis for plant SCAR/WAVE functional divergence |