| MSRP6中一个不寻常的转运域定义了一个复杂结构，该结构对于在感染恶性疟原虫的红细胞中锚定和维持Maurer氏裂隙是必需的。 |
Blancke Soares, A. |
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N/A |
An unusual trafficking domain in MSRP6 defines a complex needed for Maurer's clefts anchoring and maintenance in P. falciparum infected red blood cells |
| 一种基于数据的方法，用于建立细胞运动模式作为巨噬细胞亚型及其与细胞形态关系的预测指标 |
Kesapragada, M. |
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N/A |
A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology |
| E4F1 协调丙酮酸代谢与延伸因子复合物的活性，以确保大脑发育过程中翻译的准确性。 |
DiMichele, M. |
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N/A |
E4F1 COORDINATES PYRUVATE METABOLISM AND THE ACTIVITY OF THE ELONGATOR COMPLEX TO ENSURE TRANSLATION FIDELITY DURING BRAIN DEVELOPMENT |
| 簇大小决定人类细胞中转录工厂的形态 |
Semeraro, M. |
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N/A |
Cluster size determines morphology of transcription factories in human cells |
| 抑郁症中的扣带回前下功能连接异常：脑成像大数据与经颅磁刺激精准引导个性化干预的启示 |
Chen, X. |
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N/A |
Subgenual Anterior Cingulate Cortex Functional Connectivity Abnormalities in Depression: Insights from Brain Imaging Big Data and Precision-Guided Personalized Intervention via Transcranial Magnetic Stimulation |
| 构建泛基因组图谱 |
Garrison, E. |
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N/A |
Building pangenome graphs |
| 一种可推广的计算机制，揭示了瞬时渴望与决策之间的相互作用 |
Kulkarni, K. R. |
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N/A |
A generalizable computational mechanism underlying the interaction between momentary craving and decision-making |
| 通过代谢建模实现基于组学的单细胞真核光合生物功能特征定义 |
Burel, M. |
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N/A |
Towards an omics-based definition of unicellular eukaryote phototrophs functional traits via metabolic modelling |
| CD24+CD271+黑色素瘤癌症干细胞具有其单标记对应物的混合特征，并促进侵袭和治疗抗性。 |
Knowles, O. |
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N/A |
A CD24+CD271+ Melanoma Cancer Stem Cell Possesses Hybrid Characteristics of its Single Marker Counterparts and Promotes Invasion and Therapeutic Resistance |
| 在急性刚地弓形虫感染期间，转铁蛋白受体1对于CD4+ T细胞的铁依赖性反应是必需的。 |
Denton, S. L. |
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N/A |
Transferrin Receptor 1 is Required for CD4+ T Cell Iron-Dependent Response During Acute Toxoplasma gondii Infection |
| 分形睡眠周期：一种基于非周期性活动的新型睡眠周期定义 |
Rosenblum, Y. |
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N/A |
Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles |
| 精子竞争强度塑造了啮齿动物中精子形态和生殖基因的分化 |
Kopania, E. E. K. |
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N/A |
Sperm competition intensity shapes divergence in both sperm morphology and reproductive genes across murine rodents |
| 在老鼠的上丘中，循环电路编码了视觉中心-周围计算。 |
Cui, P. |
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N/A |
Recurrent circuits encode visual center-surround computations in the mouse superior colliculus |
| 通过时间共享光学镊子微流变学测量细胞器、细胞和生物体的年龄依赖性粘弹性特性 |
Catala-Castro, F. |
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N/A |
Measuring age-dependent viscoelastic properties of organelles, cells and organisms via Time-Shared Optical TweezerMicrorheology |
| MiRGraph：一种混合深度学习方法，通过整合异质调控网络和基因组序列来识别微RNA-靶标相互作用 |
Liu, P. |
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N/A |
MiRGraph: A hybrid deep learning approach toidentify microRNA-target interactions by integrating heterogeneous regulatory network and genomic sequences |
| AptaDiff：基于扩散模型的适配体从头设计与优化 |
Wang, Z. |
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N/A |
AptaDiff: de novo design and optimization of aptamers based on diffusion models |
| 同步呼吸：社会行为如何影响宽吻海豚的呼吸道传染病风险 |
Collier, M. A. |
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N/A |
Breathing in sync: how a social behavior structures respiratory epidemic risk in bottlenose dolphins |
| 磁性细菌的逃逸问题 - 生理磁场强度有助于磁性细菌在模拟沉积物中导航 |
Codutti, A. |
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N/A |
Escape problem of magnetotactic bacteria - physiological magnetic field strengths help magnetotactic bacteria navigate in simulated sediments |
| 努力驱动扫视选择 |
Koevoet, D. |
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N/A |
Effort Drives Saccade Selection |
| 在骨质疏松比格犬模型中使用rhPTH(1-34)和二聚体R25CPTH(1-34)增强骨再生和骨整合 |
Shin, J.-O. |
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N/A |
Enhancing Bone Regeneration and Osseointegration using rhPTH(1-34) and Dimeric R25CPTH(1-34) in an Osteoporotic Beagle Model |
| 一统天下？评估可持续森林管理指标在多分类数据下对生物多样性保护的表现 |
Paillet, Y. |
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N/A |
One to rule them all? Assessing the performance of sustainable forest management indicators against multitaxonomic data for biodiversity conservation |
| 宿主基因型在世代间积极塑造其微生物群 |
Benga, L. |
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N/A |
The host genotype actively shapes its microbiome across generations |
| 马索科湖慈鲷生态型分化过程中重组景观的快速进化 |
Talbi, M. |
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N/A |
Rapid evolution of recombination landscapes during the divergence of cichlid ecotypes in Lake Masoko |
| 违反预测增强了视觉特征在感知中的表征忠实度 |
Rideaux, R. |
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N/A |
Violated predictions enhance the representational fidelity of visual features in perception |
| 大规模基因组测序研究中的高效存储与回归计算 |
Rivas, M. A. |
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N/A |
Efficient storage and regression computation for population-scale genome sequencing studies |
| 配体耦合的环核苷酸门控离子通道中的构象变化通过时间分辨过渡金属离子FRET揭示 |
Eggan, P. |
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N/A |
Ligand-Coupled Conformational Changes in a Cyclic Nucleotide-Gated Ion Channel Revealed by Time-Resolved Transition Metal Ion FRET |
| 使用信息先验来解决存在鉴定错误的占用模型中的识别性问题 |
Monchy, C. |
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N/A |
Using informative priors to account for identifiability issues in occupancy models with identification errors |
| 一种用于慢性脊髓神经调节的主动式电子、高密度硬膜外电极阵列 |
Parker, S. R. |
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N/A |
An active electronic, high-density epidural paddle array for chronic spinal cord neuromodulation |
| 动物社会网络结构驱动因素的因果框架 |
Kawam, B. |
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N/A |
A causal framework for the drivers of animal social network structure |
| 噬菌体展示技术助力机器学习发现癌症抗原特异性T细胞受体 |
Croce, G. |
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N/A |
Phage display enables machine learning discovery of cancer antigen specific TCRs |
| 前额叶和感觉皮层中的预备性注意模板编码了与目标相关的信息。 |
Zhou, Z. |
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N/A |
Preparatory attentional templates in prefrontal and sensory cortex encode target-associated information |
| 骨髓空间转录组学揭示了多发性骨髓瘤细胞结构，伴有功能障碍的T细胞分布、中性粒捕获和中炎性信号传导 |
Sudupe, L. |
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N/A |
Bone Marrow Spatial Transcriptomics Reveals a Myeloma Cell Architecture with Dysfunctional T-Cell Distribution, Neutrophil Traps, and Inflammatory Signaling |
| 选择性烟碱型乙酰胆碱受体亚型的共激活是逆转阿尔茨海默病中海马网络功能障碍和防止恐惧记忆丧失所必需的。 |
Lee, R. |
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N/A |
Co-activation of selective nicotinic acetylcholine receptor subtypes is required to reverse hippocampal network dysfunction and prevent fear memory loss in Alzheimer's disease |
| HERMES：用于突变效应和稳定性预测的全息等变神经网络模型 |
Visani, G. M. |
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N/A |
HERMES: Holographic Equivariant neuRal network model for Mutational Effect and Stability prediction |
| 人类PIEZO1的结构及其缓慢失活的通道病突变体 |
Shan, Y. |
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N/A |
Structure of human PIEZO1 and its slow inactivating channelopathy mutants |
| 在RNA分子池中实现基因组信息的稳定复制 |
Burger, L. |
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N/A |
Toward Stable Replication of Genomic Information in Pools of RNA Molecules |
| 12-脂氧合酶抑制剂可抑制胰岛免疫和炎症反应，并延缓人基因替代小鼠的自身免疫性糖尿病进展。 |
Nargis, T. |
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N/A |
12-Lipoxygenase Inhibition Suppresses Islet Immune and Inflammatory Responses and Delays Autoimmune Diabetes in Human Gene Replacement Mice |
| 贝叶斯分层模型用于决策标准在试验间波动的研究 |
Vloeberghs, R. |
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N/A |
A Bayesian Hierarchical Model of Trial-to-Trial Fluctuations in Decision Criterion |
| 工程合成激动剂用于靶向激活Notch信号传导 |
Perez, D. H. |
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N/A |
Engineering synthetic agonists for targeted activation of Notch signaling |
| eduWOSM：一款专为教育和研究设计的高级台式显微镜 |
Carter, N. J. |
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N/A |
The eduWOSM: a benchtop advanced microscope for education and research |
| 在不同癌症类型中，以单细胞分辨率和空间背景下解析长链非编码RNA的多样性 |
Prakrithi, P. |
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N/A |
Unraveling lncRNA Diversity at a Single Cell Resolution and in a Spatial Context across Different Cancer Types |
| 小鼠中导致dRTA的SLC4A1突变引起的尿钠丢失和集合管功能紊乱 |
Mungara, P. |
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N/A |
Urinary Sodium Wasting and Disrupted Collecting Duct Function in Mice with dRTA-Causing SLC4A1 Mutations |
| RNA的替代性解码在哺乳动物中产生了稳定且丰富的蛋白质 |
Tsour, S. |
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N/A |
Alternate RNA decoding results in stable and abundant proteins in mammals |
| 肌钙蛋白C突变体中的钙结合亲和力：自由能计算、协同进化建模与机器学习 |
Pooja, |
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N/A |
Calcium Binding Affinity in the Mutational Landscape of Troponin-C: Free Energy Calculation, Coevolution modeling and Machine Learning |
| 适用于快速培养阴道细菌（如惰性乳酸杆菌）及其他阴道细菌的实用培养基配方 |
Serrador, D. |
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N/A |
Practical Media Formulations for Rapid Growth of Lactobacillus iners and Other Vaginal Bacteria |
| CD11B+CD36+细胞是促进骨形成的巨噬细胞，能够限制与年龄相关的骨质流失。 |
Koroth, J. |
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N/A |
CD11B+CD36+ cells are bone anabolic macrophages that limit age-associated bone loss |
| 行为控制的多巴胺基础 |
Ballard, I. C. |
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N/A |
A dopaminergic basis of behavioral control |
| 在斑马鱼神经杆内局部激活光遗传学NMYII会导致远距离、不对称的力传播。 |
Crellin, H. A. |
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N/A |
Local optogenetic NMYII activation within the zebrafish neural rod results in long-range, asymmetric force propagation |
| 一个统一的啮齿动物图谱揭示了背侧迷走复合体的细胞复杂性和进化分歧 |
Hes, C. |
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N/A |
A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex |
| 用于筛选异构化介导酶药物靶点的差分离子迁移声波喷射质谱系统 |
Bazargan, S. |
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N/A |
A Differential Ion Mobility Acoustic Ejection Mass Spectrometer System for Screening Isomerization-Mediating Enzyme Drug Targets |
| 已撤回：酒石黄无法使活体组织透明化 |
Inagaki, S. |
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N/A |
WITHDRAWN: Tartrazine cannot make live tissues transparent |
| 鉴定出利什曼原虫中一种新型基体定位的ε-微管蛋白 |
Seth, A. |
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N/A |
Identification of a novel basal body-localized epsilon-tubulin in Leishmania |
| 预测透析器选择和吸附剂透析液流速对胆红素清除的影响 |
Novokhodko, A. |
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N/A |
Predicting the Impact of Dialyzer Choice and Binder Dialysate Flow Rate on Bilirubin Removal |
| 实时预测药物诱导的致心律失常风险，采用性别特异性的心脏模拟器 |
Dominguez-Gomez, P. |
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N/A |
Real-time prediction of drug-induced proarrhythmic risk with sex-specific cardiac emulators |
| 开发高效且选择性的CK1α分子胶降解剂 |
Geng, Q. |
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N/A |
Development of potent and selective CK1α Molecular Glue Degraders |
| 运动皮层编码运动学习的神经景观中的分离吸引子 |
Liu, X. |
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N/A |
Separated attractors in neural landscape of motor cortex encoding motor learning |
| 人类协作中的可控性与因果关系 |
Spiering, L. |
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N/A |
Controllability and cause in human collaboration |
| 表观基因组分析揭示了H3K27me3调控人类皮层发育中外基质成分的组成 |
Ditzer, N. |
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N/A |
Epigenome profiling identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis |
| 宿主特异性决定了新的真菌植物病原体种群的出现 |
C. Fagundes, W. |
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N/A |
Host specialization defines the emergence of new fungal plant pathogen populations |
| 快速两步靶标捕获确保了高效的CRISPR-Cas9引导的基因组编辑 |
Shi, H. |
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N/A |
Rapid two-step target capture ensures efficient CRISPR-Cas9-guided genome editing |
| 藿香蓟（Agastache rugosa (Fisch. & C.A.Mey.) Kuntze）的综合生理可塑性揭示了对光和养分梯度的复杂适应性 |
Rosli, K. A. |
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N/A |
Integrative physiological plasticity of Agastache rugosa (Fisch. & C.A.Mey.) Kuntze reveals complex adaptation to light and nutrient gradients |
| 在运动规划中的高效编码 |
Wang, T. |
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N/A |
Efficient Coding in Motor Planning |
| 一种敏感的红/远红光开关，用于在小鼠代谢疾病模型中可控的基因治疗 |
Qiao, L. |
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N/A |
A sensitive red/far-red photoswitch for controllable gene therapy in mouse models of metabolic diseases |
| 捏合与拇指和食指屈曲过程中皮层表面电位的空间和光谱变化 |
Kerezoudis, P. |
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N/A |
Spatial and Spectral Changes in Cortical Surface Potentials during Pinching versus Thumb and Index Finger Flexion |
| 一种新开发的全基因组测序方案使得早期追踪肠道病毒D68的分子进化成为可能。 |
Giardina, F. A. |
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N/A |
A newly developed whole genome sequencing protocol enables early tracking of Enterovirus D68 molecular evolution. |
| 开发一种新型方法制备高功能人类浦肯野网络 |
Ji, P. |
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N/A |
Development of a Novel Method to Fabricate Highly Functional Human Purkinje Networks |
| 肠道微生物群与2型糖尿病关联：16s研究及其方法学挑战的元分析 |
Machado, J. |
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N/A |
Gut microbiota and type 2 diabetes associations: A meta-analysis of 16s studies and their methodological challenges |
| 乳腺癌中FABP4和FABP5的表达特征：临床意义与展望 |
Li, B. |
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N/A |
Expression Profiles of FABP4 and FABP5 in Breast Cancer: Clinical Implications and Perspectives |
| 五人制足球游戏训练对青春期非运动员女孩表现、自我效能、动机及运动成瘾的影响 |
Beik, S. |
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N/A |
Effect of Futsal-Based Game Training on Performance, Self-Efficacy, Motivation, and Exercise Addiction in Adolescent Non-Athlete Girls |
| 将空间扩散纳入突发性随机转录模型中 |
Miles, C. E. |
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N/A |
Incorporating spatial diffusion into models of bursty stochastic transcription |
| 使用二维和三维图像分析工具对成年小鼠脑样本中微胶质细胞形态复杂性进行比较分析 |
Murray, C. J. |
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N/A |
A comparison of microglial morphological complexity analysis in adult mouse brain samples using 2-dimensional and 3-dimensional image analysis tools |
| 使用单细胞和单核测序技术进行可扩展电路映射的高复杂度条形码狂犬病病毒 |
Shin, D. |
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N/A |
High-Complexity Barcoded Rabies Virus for Scalable Circuit Mapping Using Single-Cell and Single-Nucleus Sequencing |
| 长程相互激活在细胞迁移过程中建立Rho和Rac的极性 |
De Belly, H. |
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N/A |
Long range mutual activation establishes Rho and Rac polarity during cell migration |
| 效应异质性揭示了罕见编码变异的复杂多效性效应 |
Lu, W. |
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N/A |
Effect heterogeneity reveals complex pleiotropic effects of rare coding variants |
| 细胞类型指导的镶嵌性局灶性癫痫基因分型揭示了细胞自主性和非细胞自主性疾病相关转录程序 |
Bizzotto, S. |
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N/A |
Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs |
| 鉴定与先天性心脏病中临床报告的CNV相关的长非编码RNA候选疾病基因 |
Penaloza, J. S. |
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N/A |
Identification of Long Non-coding RNA Candidate Disease Genes Associated with Clinically Reported CNVs in Congenital Heart Disease |
| 一种综合的蛋白质组和转录组学方法揭示了新的ADAM9底物及其下游通路 |
Lu, C. |
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N/A |
An integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways |
| 先前报道的90万年前人类祖先的瓶颈期很可能是一个统计学上的假象。 |
Deng, Y. |
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N/A |
A previously reported bottleneck in human ancestry 900 kya is likely a statistical artifact |
| 重复性头部撞击暴露与慢性创伤性脑病的血浆蛋白质组质询 |
Saloner, R. |
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N/A |
Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy |
| 人口基因组学揭示了非洲本土谷物苔麸（Eragrostis tef）性状改良的位点 |
Jones, M. R. W. |
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N/A |
Population genomics uncover loci for trait improvement in the indigenous African cereal tef (Eragrostis tef) |
| 增强型激酶转位报告系统用于同时实时测量PKA、ERK和Ca2+ |
Tsai, S.-J. |
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N/A |
Enhanced kinase translocation reporters for simultaneous real-time measurement of PKA, ERK, and Ca2+ |
| 调节ATP-腺苷信号轴结合放射治疗促进脑转移中的抗癌免疫 |
Salamero-Boix, A. |
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N/A |
Modulation of the ATP-adenosine signaling axis combined with radiotherapy facilitates anti-cancer immunity in brain metastasis |
| 基于细胞提取物的体外DNA复制能够实现可持续的无细胞基因表达 |
Zheng, X. |
PDF |
N/A |
Cell extract-based in vitro DNA replication enables sustainable cell-free gene expression |
| 扩展莱茵衣藻倍性操作工具箱 |
Van de Vloet, A. |
PDF |
N/A |
Expanding the toolkit for ploidy manipulation in Chlamydomonas reinhardtii |
| 布尔网络吸引子景观的映射 |
Trinh, V.-G. |
PDF |
N/A |
Mapping the attractor landscape of Boolean networks |
| 小鼠背侧梨状皮层核的全脑连接和新奇反应 |
Manjila, S. B. |
PDF |
N/A |
Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice |
| 经验塑造了嗅觉表征沿着皮层-海马路径的转变 |
Eleonore, S. |
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N/A |
Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway |
| B细胞c-Maf信号在胰腺癌和黑色素瘤的动物模型中促进肿瘤进展 |
Zhong, Q. |
PDF |
N/A |
B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanoma |
| SIRT4通过增强NK细胞对肝星状细胞的细胞毒性，并通过AMPKα/P-p53/NKG2DL途径逆转肝纤维化。 |
Zhang, F. |
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N/A |
SIRT4 enhances the cytotoxicity of NK cells toward hepatic stellate cells and reverses liver fibrosis via AMPKα/P-p53/NKG2DL pathway |
| RNA结合蛋白Musashi1与病毒基因组RNA相互作用，并通过抑制翻译来限制SARS-CoV-2感染。 |
Ganguli, S. |
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N/A |
RNA binding protein Musashi1 interacts with the viral genomic RNA and restricts SARS-CoV-2 infection by repressing translation |
| 阿塔卡马沙漠的土壤生物多样性在不同多样性水平上呈现出明显的模式。 |
Villegas, L. |
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N/A |
Soil biodiversity in the Atacama Desert shows distinct patterns at different diversity levels |
| 使用对比学习进行遗传数据降维 |
Thor, F. |
PDF |
N/A |
Dimensionality Reduction of Genetic Data using Contrastive Learning |
| 酵母中的rDNA拷贝数变异会改变对环境条件的响应 |
Thornton, K. |
PDF |
N/A |
rDNA copy number variation in yeast alters response to environmental conditions |
| 质子通道失活导致叶绿体NDH复合物活性丧失 |
Strand, D. D. |
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N/A |
Proton channel inactivation results in loss of chloroplast NDH complex activity |
| 持续接触多价抗原修饰的纳米颗粒会产生广泛的抗冠状病毒反应。 |
Baillet, J. |
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N/A |
Sustained exposure to multivalent antigen-decorated nanoparticles generates broad anti-coronavirus responses |
| 单细胞核测序揭示肾上腺皮质癌中的复制应激 |
Popova, L. V. |
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N/A |
Single Nuclei Sequencing Reveals Replication Stress in Adrenocortical Carcinoma |
| 来自中国新疆上侏罗纪齐古组的新剑龙（恐龙纲：鸟臀目）及其对中国剑龙类系统发育的修订 |
Li, N. |
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N/A |
A new stegosaur (Dinosauria: Ornithischia) from the Upper Jurassic Qigu Formation of Xinjiang, China and a revision on Chinese stegosaurs phylogeny |
| 神经分化型内皮细胞亚型调控器官血流与免疫平衡 |
Gyarmati, G. |
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N/A |
Neuronally differentiated endothelial cell subtype regulates organ blood flow and immune balance |
| 基于合成细胞的组织用于自下而上组装人工淋巴器官 |
Burgstaller, A. |
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N/A |
Synthetic cell-based tissues for bottom-up assembly of artificial lymphatic organs |
| 利用多模态网络数据整合与分析解码帕金森病变异体间的共享分子失调 |
Zagare, A. |
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N/A |
Deciphering shared molecular dysregulation across Parkinson's disease variants using a multi-modal network-based data integration and analysis |
| 海洋杜父鱼配对鳍上的表皮微结构为支撑底栖固着机制提供了新的见解。 |
Kane, E. A. |
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N/A |
Epidermal microstructures on the paired fins of marine sculpins provide new insights into mechanisms supporting benthic station-holding |
| 多重功能分析TAP2变体在调节MHC-I细胞表面丰度中的作用揭示了PLK1的过度表达下调抗原呈递。 |
Nagy, G. |
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N/A |
Multiplexed functional analysis of TAP2 variants in regulating MHC-I cell surface abundance reveals overexpression of PLK1 downregulates antigen presentation. |
| 增加CPT1a表达是对病理应激的关键心脏保护性反应，它抑制了重塑基因程序，并使通过基因转移进行拯救成为可能。 |
Carley, A. N. |
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N/A |
Increased CPT1a expression is a critical cardioprotective response to pathological stress that suppresses gene programs for remodeling and enables rescue by gene transfer |
| 癫痫的破伤风毒素模型中突触异质性降低：计算模型提供的见解 |
Zarei Eskikabd, P. |
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N/A |
Reduced Synaptic Heterogeneity in a Tetanus ToxinModel of Epilepsy: Insights from ComputationalModeling |
| 在高度视觉化的动物中，通过注视远程激活地点代码 |
Payne, H. L. |
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N/A |
Remote activation of place codes by gaze in a highly visual animal |
| 神经代谢物T1弛豫时间的年龄依赖性 |
Murali-Manohar, S. |
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N/A |
Age dependency of neurometabolite T1 relaxation times |
| 自噬增强剂在额颞叶痴呆的干细胞模型中挽救了Tau蛋白的积累 |
Mirfakhar, F. |
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N/A |
Autophagic enhancer rescues Tau accumulation in a stem cell model of frontotemporal dementia |
| 循环蛋白塑造小胶质细胞状态并增强吞噬作用 |
Lu, N. |
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N/A |
Circulatory proteins shape microglia state and boost phagocytosis |
| 单细胞RNA测序揭示了小鼠和大鼠母体向合子过渡的早期转录程序 |
Su, Y. |
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N/A |
Single-cell RNA-seq Reveals Early Transcriptional Programs of the Maternal to Zygote Transition in Mice and Rats |
| 各向异性拉伸使多细胞水螅聚集体中的肌动蛋白纤维自组织产生偏倚 |
Bailles, A. |
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N/A |
Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates |
| 一种可持续且由蜜蜂授粉的咖啡，为你的一天拉开序幕 |
Alves, D. A. |
PDF |
N/A |
A sustainable and bee-pollinated coffee to start your day |
| 新生代进化史掩盖了棘鳍鱼类在中生代的起源。 |
Brownstein, C. D. |
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N/A |
Cenozoic evolutionary history obscures the Mesozoic origins of acanthopterygian fishes |
| 在极端代谢适应下的三维基因组组织表现出基因组区室化和环状结构的变化。 |
Biswas, T. |
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N/A |
3D genome organization under extreme metabolic adaptation shows variations in genome compartmentalization and looping |
| 一种新的古菌遗传密码的零星分布，其中所有TAG密码子均编码吡咯赖氨酸 |
Kivenson, V. |
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N/A |
Sporadic distribution of a new archaeal genetic code with all TAG codons as pyrrolysine |
| 分析桉油精、柠檬烯和蒎烯肠溶胶囊（QIENUO）治疗肺囊性纤维化的分子机制：网络药理学研究与分子对接验证 |
Tiantaixi, T. |
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N/A |
Analyzing the Molecular Mechanism of Eucalyptol, Limonene and Pinene Enteric Capsules (QIENUO) in the Treatment of Pulmonary cystic fibrosis with Network Pharmacology and Verifying Molecular Docking |
| 通过整合序列和结构特征，增强蛋白质功能身份的预测 |
Fujita, S. |
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N/A |
Enhanced prediction of protein functional identity through the integration of sequence and structural features |
| 突变型IDH使p53与靶基因调控分离，从而抑制肿瘤抑制功能 |
Martin, C. P. |
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N/A |
Mutant IDH uncouples p53 from target gene regulation to disable tumor suppression |
| 通过罗望子果实果肉乙醇提取物减轻氟化钠处理对Wistar大鼠生殖功能的抑制作用 |
Usman, L. A. |
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N/A |
Mitigation of Reproductive Function in Sodium Fluoride-administered Wistar Rats by Tamarindus indica Fruit Pulp Ethanol Extract |
| 探索新领域：一种新型Cdk5抑制剂恢复认知功能并缓解2型糖尿病 |
Paul, S. |
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N/A |
Exploring New Horizons:A Novel Cdk5 Inhibitor Restoring Cognitive Function and Alleviating Type 2 Diabetes. |
| 社会性塑造了支持低氧耐受性的线粒体适应 |
Rossi, A. |
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N/A |
Sociality shapes mitochondrial adaptations supporting hypoxia tolerance |
| 内皮下钙化增加表面粗糙度，并促进脂质沉积到动脉壁中。 |
Kosciuszek, N. D. |
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N/A |
Subendothelial Calcification Increases Surface Roughness and Promotes Lipid Deposition into the Arterial Wall |
| 后顶叶皮层调节前额眼区中的内在神经时间尺度和注意处理 |
Soyuhos, O. |
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N/A |
Posterior Parietal Cortex Regulates Intrinsic Neural Timescales and Attentional Processing in Frontal Eye Field |
| SARM1的缺失可防止常染色体显性视神经萎缩中的视网膜神经节细胞退化。 |
Ding, C. |
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N/A |
Loss of SARM1 protects against retinal ganglion cell degeneration in Autosomal Dominant Optic Atrophy |
| Galnt2神经元丢失损害O-糖基化并导致模拟GALNT2-CDG的神经行为缺陷 |
Edmondson, A. C. |
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N/A |
Neuronal loss of Galnt2 Impairs O-glycosylation and Leads to Neurobehavioral Deficits Mimicking GALNT2-CDG |
| 前丘脑中与心率相关的活动在相位性和紧张性快速眼动睡眠期间有所不同。 |
Simor, P. |
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N/A |
Heartbeat related activity in the anterior thalamus differs between phasic and tonic REM sleep periods |
| 双特异性磷酸酶3（Dual Specificity Phosphatase 3）的敲低促使髓系白血病细胞分化为巨噬细胞并极化。 |
Farias, J. O. |
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N/A |
Dual Specificity Phosphatase 3 knockdown drives myeloid leukemia cells to differentiate into macrophages and polarize |
| 人胰腺导管类器官中的旋转迁移依赖于肌动蛋白和肌球蛋白的活性。 |
Xie, G. |
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N/A |
Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity |
| 评估跨平台归一化方法以进行综合微阵列和RNA测序数据分析 |
Sun, X. |
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N/A |
Evaluating Cross-Platform Normalization Methods for Integrated Microarray and RNA-seq Data Analysis |
| 微通道内增强的细菌趋化性：在通道宽度与圆形游泳半径匹配时达到最佳性能 |
Yue, C. |
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N/A |
Enhanced bacterial chemotaxis in confined microchannels: Optimal performance in lane widths matching circular swimming radius |
| 年龄相关性的PDE11A4蛋白表达增加会触发酶的液-液相分离（LLPS），而这种相分离可以通过PDE11A4小分子抑制剂逆转。 |
Amurrio, E. |
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N/A |
Age-related increases in PDE11A4 protein expression trigger liquid:liquid phase separation (LLPS) of the enzyme that can be reversed by PDE11A4 small molecules inhibitors |
| 认知控制中的前摄、反应和注意动态的计算建模 |
Mistry, P. K. |
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N/A |
Computational Modeling of Proactive, Reactive, and Attentional Dynamics in Cognitive Control |
| FB5P-seq-mAbs：从FB5P-seq库中制备单克隆抗体，用于B细胞的整合单细胞分析 |
Ado, S. |
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N/A |
FB5P-seq-mAbs: monoclonal antibody production from FB5P-seq libraries for integrative single-cell analysis of B cells |
| Spc105-Kre28复合体通过外侧动粒招募Ipl1/Aurora B激酶促进有丝分裂错误校正 |
Dudziak, A. |
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N/A |
The Spc105-Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of the Ipl1/Aurora B kinase |
| UBR-1缺乏导致C. elegans对伊维菌素的抗性 |
Li, Y. |
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N/A |
UBR-1 deficiency leads to ivermectin resistance in C. elegans |
| 拓扑异构酶2B和核纤层B受体协同调控基因组与核纤层相互作用 |
Manzo, S. G. |
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N/A |
Coordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor |
| IgBlend：在抗体语言模型中统一三维结构和序列 |
Malherbe, C. |
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N/A |
IgBlend: Unifying 3D Structures and Sequences in Antibody Language Models |
| 基于模拟的推断中更优的置信区间 |
Rousset, F. |
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N/A |
Better confidence intervals in simulation-based inference |
| 微缩图：无监督地将多重组织成像数据集的缩略图作为数据门户的预览 |
Taylor, A. J. |
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N/A |
Miniature: Unsupervised glimpses into multiplexed tissue imaging datasets as thumbnails for data portals |
| PHLOWER - 使用Hodge拉普拉斯分解进行单细胞轨迹分析 |
Cheng, M. |
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N/A |
PHLOWER - Single cell trajectory analysis using Decomposition of the Hodge Laplacian |
| LINE-1核糖核蛋白复合物通过与DNA结合，在有丝分裂期间促进核内进入。 |
Zernia, S. |
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N/A |
LINE-1 ribonucleoprotein complexes bind DNA to enable nuclear entry during mitosis |
| 探究烃类交联剂对p53钉合肽结构及结合能力的影响 |
Choudhury, A. R. |
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N/A |
Exploring the effect of Hydrocarbon Cross-linkers on the Structure and Binding of Stapled p53 Peptides |
| N-乙酰-2-氨基芴（AAF）：通过来自多周期肝致癌性喂养方案的癌前肝细胞原代培养，揭示了生长周期依赖性大分子结合常数KD的体内时间表达模式 |
Koch, K. S. |
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N/A |
N-Acetyl-2-Aminofluorene (AAF): In vivo temporal expression patterns of growth cycle-dependent macromolecular binding constants KD are revealed by primary cultures of premalignant hepatocytes derived from a multi-cyclic hepatocarcinogenic feeding regimen |
| 通过动力学分类实现可调的配体辨别 |
Dixit, P. D. |
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N/A |
Tunable ligand discrimination via kinetic sorting |
| 单细胞通过“异或”和“不等于”逻辑在二聚体中识别非自我与自我 |
An, R. |
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N/A |
Single Cells Signal Non-self from Self via 'XOR' and 'NOT EQUALS' Logic in a Dimer of Dimers |
| 使用肌电图进行可泛化的手势识别 |
Yun, R. |
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N/A |
Generalizable gesture recognition usingmagnetomyography |
| 利用肌电图进行可泛化的手势识别 |
Yun, R. |
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N/A |
Generalizable gesture recognition usingmagnetomyography |
| 快速眼动睡眠期间θ频带活动的时空模式：一项脑磁图分析 |
Provias, V. |
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N/A |
Spatiotemporal patterns of theta-band activity during rapid-eye movement sleep: a magnetoencephalography analysis |
| 在Dravet综合征的小鼠模型中，表达Parvalbumin的中间神经元的异位动作电位发放显著减弱。 |
Hill, S. F. |
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N/A |
Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet Syndrome |
| 使用各向同性ADC-fMRI技术绘制人脑灰质和白质活动图 |
Spencer, A. P. C. |
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N/A |
Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI |
| 一项针对与精神分裂症相关基因的果蝇筛选研究强调了神经和胶质细胞中的基质金属蛋白酶在神经重塑中的必要性。 |
Keret, S. |
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N/A |
A Drosophila screen of schizophrenia-related genes highlights the requirement of neural and glial matrix metalloproteinases for neuronal remodeling |
| 自适应时空框架用于自动E/MEG源成像 |
Feng, Z. |
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N/A |
STARTS: A self-adapted spatio-temporal framework for automatic E/MEG source imaging |
| 历史偏差及其对猕猴前额叶皮层刺激表征的扰动。 |
Benozzo, D. |
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N/A |
History bias and its perturbation of the stimulus representation in the macaque prefrontal cortex. |
| 利用牵张反射模型从肌电图（EMG）中估计快速和慢速运动中的下行激活模式 |
Zhang, L. |
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N/A |
Estimating descending activation patterns from EMG in fast and slow movements using a model of the stretch reflex |
| 使用自动编码器生成信号和ResNet分类的脑刺激伪影鲁棒检测 |
Saal, J. |
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N/A |
Robust Detection of Brain Stimulation Artifacts in iEEG Using Autoencoder-Generated Signals and ResNet Classification |
| 多样化的钙动力学支撑着海马CA1锥体细胞中位置场的形成 |
Sumegi, M. |
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N/A |
Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells |
| 验证运动校正后的MPRAGE与常规MPRAGE在儿童形态学分析中的一致性 |
Gal-Er, B. |
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N/A |
Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis |
| 计算建模揭示了神经生物学对静态和动态功能连接模式的贡献 |
Hoheisel, L. |
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N/A |
Computational modelling reveals neurobiological contributions to static and dynamic functional connectivity patterns |
| 稳定的Netrin-1荧光报告鸡揭示了视裂闭合过程中细胞特异性的分子特征。 |
Chan, B. H. C. |
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N/A |
A stable Netrin-1 fluorescent reporter chicken reveals cell-specific molecular signaturesduring optic fissure closure. |
| 林地驯鹿在危险栖息地的社会促进作用：对火灾和道路的反应 |
Hendrix, J. G. |
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N/A |
Social facilitation of risky habitats in woodland caribou: responses to fire and roads |
| 对存在采样强度偏差和删失的动物网络进行稳健贝叶斯分析 |
Sosa, S. |
PDF |
N/A |
Robust Bayesian analysis of animal networks subject to biases in sampling intensity and censoring |
| 竞争排斥、基于经验的学习以及人类捕捞活动，对幼年及成年褐鹈鹕（Pelecanus occidentalis）的活动模式产生影响。 |
Plazas-Cardona, D. |
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N/A |
Competitive exclusion, experience-based learning, and human fishing, influence activity patterns in Juvenile and Adult Brown Pelicans (Pelecanus occidentalis) |
| 通过异质OATP-配体相互作用图神经网络（HOLI-GNN）预测OATP1B1抑制剂 |
Mardikoraem, M. |
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N/A |
Predicting Inhibitors of OATP1B1 via Heterogeneous OATP-Ligand Interaction Graph Neural Network (HOLI-GNN) |
| 三维微结构的快速原型制作：一种简化的灰度光刻编码方法，使用Blender软件实现 |
Borghi, F. F. |
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N/A |
Rapid Prototyping of 3D Microstructures: A Simplified Grayscale Lithography Encoding Method Using Blender |
| 利用工程化病毒样颗粒进行活细胞转录组学 |
Najia, M. A. |
PDF |
N/A |
Live-cell transcriptomics with engineered virus-like particles |
| ClassiCOL：通过胶原蛋白肽模糊性进行古代物种分类的LC-MS/MS分析 |
Engels, I. |
PDF |
N/A |
ClassiCOL: LC-MS/MS analysis for ancient species Classification via Collagen peptide ambiguation |
| 关于残基D1-V185在Synechocystis 6803和Thermosynechococcus vestitus中光系统II功能中的作用的新见解。 |
BOUSSAC, A. |
PDF |
N/A |
New insights into the involvement of residue D1-V185 in Photosystem II function in Synechocystis 6803 and Thermosynechococcus vestitus. |
| mTOR信号通过3'UTR介导的翻译控制促进T细胞中的细胞因子产生 |
Jurgens, A. P. |
PDF |
N/A |
mTOR signaling promotes cytokine production in T cells through 3UTR-mediated translation control |
| 阴道毛滴虫胞外囊泡抑制IFNϵ介导的对宿主细胞溶解的保护作用 |
Kochanowsky, J. A. |
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N/A |
Trichomonas vaginalis extracellular vesicles suppress IFNϵ-mediated protection against host cell cytolysis |
| 凝胶内重折叠使得在SDS-PAGE后能够对完全变性的GFP进行荧光检测。 |
Shiratori, M. |
PDF |
N/A |
In-gel refolding allows fluorescence detection of fully denatured GFPs after SDS-PAGE |
| G4停滞的CMG的冷冻电镜结构揭示了DNA易位的尺蠖机制 |
Batra, S. |
PDF |
N/A |
Cryo-EM structures of G4-stalled CMG reveal inchworm mechanism of DNA translocation |
| 致癌蛋白TEL-ABL的自磷酸化使其对变构ABL抑制剂阿西米尼产生耐药性。 |
Muratcioglu, S. |
PDF |
N/A |
Autophosphorylation of the oncogenic protein TEL-ABL confers resistance to the allosteric ABL inhibitor asciminib |
| 工程化合成多价VHH抗体识别SARS-Cov-2刺突蛋白的结构基础 |
Lujan Hernandez, A. G. |
PDF |
N/A |
Structural basis of SARS-Cov-2 spike recognition by engineered synthetic multivalent VHH antibodies |
| 一种经过工程改造的染色质蛋白，增强了其对H3K27me3相对于H3K9me3的优先结合能力 |
Franklin, K. A. |
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N/A |
An engineered chromatin protein with enhanced preferential binding of H3K27me3 over H3K9me3 |
| 利用冈比亚按蚊密度病毒（AgDNV）内含子表达系统表达冈比亚按蚊内源性微小RNA |
Johnson, R. M. |
PDF |
N/A |
Expression of endogenous Anopheles gambiae microRNAs using an Anopheles gambiae densovirus (AgDNV) intronic expression system |
| 软X射线断层扫描揭示了在tasA缺失后B.subtilis生物膜结构的变异 |
Chatzimpinou, A. |
PDF |
N/A |
Soft X-ray tomography reveals variations in B.subtilis biofilm structure upon tasA deletion |
| 疟原虫运动中的牵引力生成受疟原虫粘附蛋白TLP的调节。 |
Ripp, J. |
PDF |
N/A |
Traction force generation in motile malaria parasites is modulated by the Plasmodium adhesin TLP |
| 从太平洋牡蛎中分离得到的加利西亚单胞菌（Gallaecimonas pentaromativorans）10A株的基因组显示了其降解碳氢化合物和CRISPR-Cas防御的潜力。 |
Gouin, Y. |
PDF |
N/A |
The genome of Gallaecimonas pentaromativorans strain 10A, isolated from a Pacific oyster, reveals the potential for hydrocarbon degradation and CRISPR-Cas defense |
| 种间系统生物学将细菌代谢途径与线虫的基因表达、行为和生存联系起来。 |
Athanasouli, M. |
PDF |
N/A |
Interspecies systems biology links bacterial metabolic pathways to nematode gene expression, behavior, and survival |
| 刚地弓形虫PROP1在慢性感染期间对自噬和寄生虫存活至关重要 |
Thaprawat, P. |
PDF |
N/A |
Toxoplasma gondii PROP1 is critical for autophagy and parasite viability during chronic infection |
| 土壤深度决定了高粱田中的微生物群落 |
Murray, E. R. |
PDF |
N/A |
Soil depth determines the microbial communities in Sorghum bicolor fields |
| 核糖体蛋白的过度表达导致大肠杆菌对锌产生抗性 |
Kosaki, T. |
PDF |
N/A |
Overexpression of Ribosomal Proteins Leads to Zn Resistance in Escherichia coli |
| 内部框架翻译产生Cas11b，这对于古菌CRISPR-Cas系统中的有效干扰至关重要。 |
Sailer, A.-L. |
PDF |
N/A |
Internal in-frame translation generates Cas11b, which is important for effective interference in an archaeal CRISPR-Cas system |
| MukBEF SMC复合物捕获DNA的机制及其被病毒DNA模拟物抑制的机制 |
Bürmann, F. |
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N/A |
Mechanism of DNA entrapment by the MukBEF SMC complex and its inhibition by a viral DNA mimic |
| 纳米纹理钢表面具有抗真菌活性 |
Tripathi, A. |
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N/A |
Nanotextured steel surface exhibits antifungal activity |
| 环境中的多硫化物促进在厌氧条件下生长的微生物的蛋白质二硫键形成。 |
Liu, H. |
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N/A |
Environmental polysulfides promote protein disulfide bond formation of microorganisms growing under anaerobic condition |
| 基因组范围内体内动态的cohesin介导的环挤压及其在转录激活中的作用 |
Popay, T. M. |
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N/A |
Genome-wide in vivo dynamics of cohesin-mediated loop extrusion and its role in transcription activation |
| 基于转录组的全基因组范围内鉴定冈比亚按蚊的长非编码RNA（lncRNA） |
Xu, J. |
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N/A |
Transcriptome-based identification of long noncoding RNAs (lncRNAs) across the genome of Anopheles gambiae |
| 综合多组学特征揭示了绝经后人类卵巢中阿霉素诱导的细胞衰老。 |
Devrukhkar, P. R. |
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N/A |
A comprehensive multi-omics signature of doxorubicin-induced cellular senescence in the postmenopausal human ovary. |
| MORC-1是秀丽隐杆线虫（C. elegans）CSR-1生殖系基因许可机制的关键组成部分。 |
Kirshner, J. A. |
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N/A |
MORC-1 is a key component of the C. elegans CSR-1 germline gene licensing mechanism |
| 早期干预使用低剂量硬化蛋白抗体治疗可减少卵巢切除大鼠初始骨丢失后由成骨细胞介导的继发性矿化 |
Naqvi, S. M. |
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N/A |
Early Intervention with Low-Dose Sclerostin Antibody Therapy can Reduce Osteocyte-mediated Secondary Mineralization after initial bone loss in Ovariectomised Rats |
| VCP、VCPIP1 和 p47 的三元复合物形成促进了高尔基体的重新组装。 |
Shah, B. |
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Ternary complex formation of VCP, VCPIP1 and p47 facilitates Golgi reassembly |
| inPhase - 一种简单、准确且快速的方法来确定蛋白质凝聚相图 |
Fritsch, A. W. |
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N/A |
inPhase - A simple, accurate and fast approach to determine phase diagrams of protein condensates |
| 西西米迪蒂斯：具有锌-四半胱氨酸模体和天冬酰胺酰化的RiPPs |
Zhu, A. |
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N/A |
Cysimiditides: RiPPs with a Zn-tetracysteine motif and aspartimidylation |
| 从共同的前生物激活中间体中，肽和RNA的交叉催化增强 |
Roy, R. |
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N/A |
Cross-catalytic enhancement of peptides and RNA from a common prebiotic activated intermediate |
| 丘脑室旁核中垂体腺苷酸环化酶激活多肽（PACAP）的过度表达改变了雌性大鼠的动机和情感行为 |
Carpenter, B. A. |
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N/A |
Pituitary adenylate cyclase-activating polypeptide (PACAP) overexpression in the paraventricular nucleus of the thalamus alters motivated and affective behavior in female rats |
| 视觉特征注意控制的分层组织 |
Meyyappan, S. |
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N/A |
Hierarchical Organization of Visual Feature Attention Control |
| 在思想的连续流动中，自发记忆回忆和未来思考的神经动力学 |
Su, H. |
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N/A |
Neural dynamics of spontaneous memory recall and future thinking in the continuous flow of thoughts |
| 致病相关脑膜炎奈瑟菌丝状噬菌体MDA{varphi}的结构 |
Boehning, J. |
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Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDA{varphi} |
| Meru 协调纺锤体取向与细胞极性和细胞周期进程 |
McLellan, M. M. |
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Meru co-ordinates spindle orientation with cell polarity and cell cycle progression |
| 一种用于跨物种小脑发育比较研究的最低限度引导类器官模型 |
Guglielmi, L. |
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N/A |
A minimally guided organoid model for cross-species comparisons of cerebellar development |
| 逐步、模块化的均一大脑类器官设计，代表神经元与胶质细胞之间动态的细胞相互作用 |
Kim, E. |
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N/A |
A stepwise, modular design of building uniform brain assembloids representing the dynamic cellular interplay between neurons and glial cells |
| 对听觉反馈操作的敏感性和个体差异 |
Ozker, M. |
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N/A |
Susceptibility to auditory feedback manipulations and individual variability |
| 导致智力障碍的KIF11基因突变会损害微管动力学和树突分支 |
Wingfield, J. L. |
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Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization |
| 纹状体的调节支持特定策略的强化，而非动作选择 |
Hodge, A. T. |
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N/A |
Striatal modulation supports policy-specific reinforcement and not action selection |