| 肿瘤细胞-脂肪细胞间隙连接激活脂肪分解，并促进乳腺癌的发生 |
Williams, J. |
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Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis |
| 气味通过果蝇的味觉受体神经元驱动进食。 |
Wei, H.-p. |
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N/A |
Odors drive feeding through gustatory receptor neurons in Drosophila |
| 超声波抑制SARS-CoV-2体外感染性 |
Veras, F. P. |
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Ultrasound inhibits SARS-CoV-2 infectivity in vitro |
| 人类自噬起始ULK1C:PI3KC3-C1超复合物的结构与激活 |
Chen, M. |
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Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex |
| TIM-4 识别表达 RORγT 驱动的促炎细胞因子模块的效应 B 细胞，促进免疫应答 |
Ding, Q. |
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TIM-4 Identifies Effector B cells Expressing a RORγT-driven Proinflammatory Cytokine Module That Promotes Immune responsiveness |
| 打开物种箱：简约的微观物种形成模型对宏观进化的启示 |
Couvert, E. |
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Opening the species box: What parsimonious microscopic models of speciation have to say about macroevolution |
| 可解释的多尺度结构保留单细胞RNA测序数据嵌入模型 |
Novak, D. |
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Interpretable models for scRNA-seq data embedding with multi-scale structure preservation |
| 通过体内注射和电穿孔裸露mRNA恢复患有少弱畸精子症小鼠的精子生育力 |
Vilpreux, C. |
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Sperm fertility restoration in mice suffering from oligo-astheno-teratozoospermia by in vivo injection and electroporation of naked mRNA |
| 共享的句法和形态结构神经计算：来自汉语普通话的证据 |
Yu, X. |
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Shared neural computations for syntactic and morphological structures: evidence from Mandarin Chinese |
| HairSplitter：从长且有噪声的读取中进行单体型组装 |
Faure, R. |
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HairSplitter: haplotype assembly from long, noisy reads |
| 从BioModels中筛选模型：开发创建OMEX文件的工作流程 |
Xu, J. |
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Curating models from BioModels: Developing a workflow for creating OMEX files |
| 内侧前额叶皮层的特定层次输入与应激易感性相关 |
Solakoglu, S. T. |
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Layer-specific input to medial prefrontal cortex is linked to stress susceptibility |
| 纹状体脑片中持续活动模式对多巴胺释放的调控 |
Boumhaouad, S. |
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Regulation of dopamine release by tonic activity patterns in the striatal brain slice |
| 整合跨振荡功率频段的数据可预测癫痫病灶区：频率范围探索癫痫病灶区（FREEZ）识别算法 |
O'Leary, S. |
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Integrating Data Across Oscillatory Power Bands Predicts the Epileptogenic Zone: the Frequency Range Explorer Epileptogenic Zone (FREEZ) Identification Algorithm |
| 佐剂递送方法及纳米颗粒电荷对肽酰胺微泡疫苗生物活性的影响 |
Zhang, R. |
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Adjuvant Delivery Method and Nanoparticle Charge Influence Peptide Amphiphile Micelle Vaccine Bioactivity |
| 两栖动物基因组学联盟：推动两栖动物研究与保护的基因组学和遗传资源发展 |
Kosch, T. A. |
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N/A |
The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation |
| 高度相似的氯代烷烃还原脱卤酶的动力学对比 |
Picott, K. |
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Contrasting kinetics of highly similar chloroalkane reductive dehalogenases |
| 行走于蜿蜒小径时的侧向不稳定性概率 |
Render, A. C. |
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Probability of Lateral Instability While Walking on Winding Paths |
| 流感病毒感染经历会改变肺部结构细胞的动态，从而在病毒再次攻击后迅速获得免疫保护。 |
Worrell, J. C. |
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Lung structural cell dynamics are altered by influenza virus infection experience leading to rapid immune protection following viral re-challenge |
| 小说口头指令招募了时间变量信息维度抽象神经模式 |
Pena, P. |
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Novel verbal instructions recruit abstract neural patterns of time-variable information dimensionality |
| 评估AEV01在胶质瘤和肝细胞癌中的抗肿瘤疗效及安全性：体外和体内研究方法。 |
Biswas, I. |
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Evaluating the Anti-tumor efficacy and safety of AEV01 in Glioma and Hepatocellular Carcinoma: An In Vitro and In Vivo approach. |
| 皮质醇动态变化及斑马鱼幼体暴露于重复应激下的糖皮质激素受体依赖性反馈调节 |
Castillo-Ramirez, L. A. |
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N/A |
Cortisol dynamics and GR-dependent feedback regulation in zebrafish larvae exposed to repeated stress |
| 气候变化、农药和药物对孔雀鱼（Nothobranchius furzeri）生命史和行为综合影响的研究 |
Kim, D. |
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N/A |
The combined impact of climate change, pesticides and pharmaceuticals on life history and behaviour in killifish (Nothobranchius furzeri) |
| 多巴胺与时间折扣：重新审视药理学与个体差异 |
Smith, E. |
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Dopamine and temporal discounting: revisiting pharmacology and individual differences |
| 大小-重量错觉及其超越：一种感知重量的新模型 |
Pisu, V. |
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The size-weight illusion and beyond: a new model of perceived weight |
| 一种新的Betaflexivirus属病毒在Ferraria crispa植物中被发现 |
Dekker, R. J. |
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A new Betaflexivirus species in Ferraria crispa plants |
| 在Lachenalia植物中发现的新型Phenuivirus物种揭示了5'和3' RNA序列基序之间可能的协同进化 |
Dekker, R. J. |
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Discovery of a new Phenuivirus species in Lachenalia plants reveals possible co-evolution between 5' and 3' RNA sequence motifs |
| 结构蛋白质组学揭示了孕酮受体的顺序启动机制 |
Mann, M. D. |
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Structural proteomics defines a sequential priming mechanism for the progesterone receptor |
| 人类视觉皮层在准备期间的双格式注意模板 |
Chen, Y. |
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Dual-format attentional template during preparation in human visual cortex |
| 缺失但未受糖皮质激素调节的促肾上腺皮质激素释放激素（Crh）调控小鼠的焦虑样行为 |
Friedman, H. R. |
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Absent, but not glucocorticoid-modulated, corticotropin-releasing hormone (Crh) regulates anxiety-like behaviors in mice |
| Lumen电荷调控β-桶状纳米孔中的忆阻离子传输 |
Mayer, S. F. |
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Lumen charge governs memristive ion transport in β-barrel nanopores |
| 调节秀丽隐杆线虫进入持久幼虫状态决策的神经元活动 |
Prakash, S. J. |
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Neuronal activity regulating the dauer entry decision in Caenorhabditis elegans |
| RAPDOR：利用Jensen-Shannon距离进行复杂蛋白质组学数据集的计算分析 |
Hemm, L. |
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RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics datasets |
| 经验塑造了嗅觉表征沿着皮层-海马路径的转变 |
Schiltz, E. |
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Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway |
| RNA结合蛋白Musashi1与病毒基因组RNA相互作用，并通过抑制翻译来限制SARS-CoV-2感染。 |
Ganguli, S. |
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RNA binding protein Musashi1 interacts with the viral genomic RNA and restricts SARS-CoV-2 infection by repressing translation |
| 阿塔卡马沙漠的土壤生物多样性在不同多样性水平上呈现出明显的模式。 |
Villegas, L. |
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Soil biodiversity in the Atacama Desert shows distinct patterns at different diversity levels |
| ClassiCOL：通过胶原蛋白肽模糊性进行古代物种分类的LC-MS/MS分析 |
Engels, I. |
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ClassiCOL: LC-MS/MS analysis for ancient species Classification via Collagen peptide ambiguation |
| 从太平洋牡蛎中分离得到的Gallaecimonas pentaromativorans菌株10A的基因组显示了其降解碳氢化合物和CRISPR-Cas防御的潜力。 |
Gouin, Y. |
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The genome of Gallaecimonas pentaromativorans strain 10A, isolated from a Pacific oyster, reveals the potential for hydrocarbon degradation and CRISPR-Cas defense |
| 基于转录组的全基因组长非编码RNA（lncRNA）在冈比亚按蚊中的鉴定 |
Xu, J. |
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Transcriptome-based identification of long noncoding RNAs (lncRNAs) across the genome of Anopheles gambiae |
| 开发并验证一种计算工具，用于预测高级别浆液性卵巢癌患者细胞的治疗结果 |
Cortesi, M. |
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Development and validation of a computational tool to predict treatment outcomes in cells from High-Grade Serous Ovarian Cancer patients |
| 利用全基因组代谢网络分析神经发育，研究自闭症谱系障碍中的细胞代谢功能障碍 |
Pourmajidian, M. |
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Investigation of cell metabolism dysfunction in autism spectrum disorders using genome-scale metabolic network analysis of neuronal development |
| 期望引发音乐引发的寒颤 |
de Fleurian, R. |
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Expectation elicits music-evoked chills |
| 亲社会奖励与言语接收阈值相关，而年龄与噪声中言语感知的主观评分相关。 |
Oakeson, R. J. |
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Prosocial reward relates to speech reception thresholds and age relates to subjective ratings of speech perception in noise |
| 常染色体显性额颞叶痴呆临床表现中的性别差异 |
Memel, M. |
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Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia |
| 雷帕霉素免疫调节利用时间依赖性的淋巴结结构改变、白细胞迁移和肠道微生物群的变化 |
Wu, L. |
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Rapamycin Immunomodulation Utilizes Time-Dependent Alterations of Lymph Node Architecture, Leukocyte Trafficking, and Gut Microbiome |
| 在产前暴露于较高水平母体炎症的中年/老年成人中，海马神经突密度降低 |
Mohyee, R. A. |
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Decreased hippocampal neurite density in middle-aged/aging adults following prenatal exposure to higher levels of maternal inflammation |
| 全球木本植物群落的代谢生长机制与理论生长潜力 |
Shu, S. |
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N/A |
Metabolic growth mechanisms and theoretical growth potential of global woody plant communities |
| 水生食物对小岛屿发展中国家人类营养摄入和充足性的贡献 |
Zamborain-Mason, J. |
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N/A |
The contribution of aquatic foods to human nutrient intake and adequacy in a Small Island Developing State |
| BCL-xL复合物尾部锚定对BH3-in-沟槽相互作用的全局调节限制了BH3模拟拮抗作用。 |
Maillet, L. |
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Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism. |
| 细胞内核周β-肾上腺素受体在定义信号分隔和病理心脏重塑中的独特作用 |
Turcotte, M. G. |
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The Unique Role of Intracellular Perinuclear β-Adrenergic Receptors in defining Signaling Compartmentation and Pathological Cardiac Remodeling |
| 部分共享的多模态嵌入学习细胞状态的整体表示 |
Zhang, X. |
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N/A |
Partially Shared Multi-Modal Embedding Learns Holistic Representation of Cell State |
| 使用新型荧光HPLC法量化小GTP酶的激活状态 |
Araki, M. |
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Quantifying small GTPase activation status using a novel fluorescence HPLC-based assay |
| GLA-3介导秀丽隐杆线虫生殖细胞中的应激反应：Tristetraprolin（TTP）家族的关键作用 |
Salinas, L. S. |
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GLA-3 Mediates Stress Response in Caenorhabditis elegans Germ Cells: A key role of the Tristetraprolin (TTP) Family |
| 一种可诱导且可逆的系统，用于调控秀丽隐杆线虫中不饱和脂肪酸的生物合成 |
Battista, B. |
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N/A |
An inducible and reversible system to regulate unsaturated fatty acid biosynthesis in C. elegans |
| 胶质母细胞瘤的侵袭依赖于肌动蛋白-肌球蛋白的收缩性和金属蛋白酶的活性。 |
Sumajit, H. |
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N/A |
Glioblastoma invasion relies on actomyosin contractility and metalloproteinase activity |
| 基于Hsp90-Tau相互作用的合成伴侣蛋白抑制病理性Tau聚集并恢复生理性Tau-微管相互作用 |
Di Lorenzo, D. |
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Synthetic chaperone based on Hsp90-Tau interaction inhibits pathological Tau aggregation and rescues physiological Tau-Microtubule interaction |
| PHD3-FOXO3轴调节小胶质细胞中的I型干扰素反应，加剧阿尔茨海默病进展 |
Sanchez-Garcia, M. A. |
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N/A |
The PHD3-FOXO3 axis modulates the interferon type I response in microglia aggravating Alzheimer's disease progression |
| 雌性小鼠犁鼻器中雄性特征的表达及其在动情周期中的稳定性 |
Ben-Shaul, Y. |
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N/A |
Representation of male features in the female mouse Accessory Olfactory Bulb, and their stability during the estrus cycle |
| 检测身体对组织过度生长的生殖激素制动器：micrin/SgII-70 |
Hart, J. E. |
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Detecting the bodys reproductive hormonal brake against tissue overgrowth: micrin/SgII-70 |
| 高血压Bph/2小鼠与正常血压Bpn/3小鼠之间淋巴细胞亚群的差异组成及激活状态 |
Dattmore, D. A. |
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Differential composition of lymphocyte subpopulations and activation between the hypertensive Bph/2 and normotensive Bpn/3 mouse strains |
| 荷斯坦奶牛生乳中细菌群落的组成与肺炎克雷伯菌临床乳腺炎感染的发生相关 |
O'Brien, B. |
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N/A |
The Composition of the Bacterial Community in Raw Milk from Holstein Dairy Cattle Correlated with the Occurrence of Klebsiella pneumoniae Clinical Mastitis Infections |
| 环境基质和水分是决定在简化土壤模拟环境中表达的微生物表型的关键因素。 |
Rodriguez-Ramos, J. A. |
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N/A |
Environmental matrix and moisture are key determinants of microbial phenotypes expressed in a reduced complexity soil-analog |
| 一项针对三个国家的肠道微生物组分析显示，与饮食相关的分类群关联因地理位置和菌株而异。 |
Khatib, L. |
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N/A |
A three-country analysis of the gut microbiome indicates taxon associations with diet vary by location and strain |
| Sciphy：一种使用顺序遗传谱系追踪数据的贝叶斯系统发育框架。 |
Seidel, S. |
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Sciphy: A Bayesian phylogenetic framework using sequential genetic lineage tracing data. |
| 鸟类捕食评估的准确性：相机陷阱测试橡皮泥毛虫作为猎物模型的有效性 |
SCHILLE, L. |
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N/A |
Accuracy in bird predation assessment: Camera traps testing the efficacy of plasticine caterpillars as prey models |
| 重建MAPK信号网络的深层系统发育：通过多层次协同进化扩展实现功能特化 |
Huang, E. |
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N/A |
Reconstructing the deep phylogeny of the MAPK signaling network: functional specialization via multi-tier coevolutionary expansion |
| 念珠菌基因组数据库：注释与可视化更新 |
Lew-Smith, J. |
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N/A |
The Candida Genome Database: Annotation and Visualization Updates |
| 人工照明影响捕食性臭虫Orius insidiosus（Say）对西方花蓟马Frankliniella occidentalis（Pergande）的捕食效果 |
Canovas, M. L. |
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N/A |
Artificial lighting affects the predation performance of the predatory bug Orius insidiosus (Say) against the Western flower thrips Frankliniella occidentalis (Pergande) |
| 一项简单的措施能减少小鼠的食量并降低肥胖率 |
Barrett, M. R. |
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N/A |
A simple action reduces food intake and obesity in mice |
| 使用HarmoDecon缓解空间分辨转录组学中细胞类型反卷积的多尺度偏差 |
Wang, Z. |
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N/A |
Mitigation of multi-scale biases in cell-type deconvolution for spatially resolved transcriptomics using HarmoDecon |
| ProteusAI：一个开源且用户友好的平台，用于机器学习引导的蛋白质设计和工程 |
Funk, J. |
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N/A |
ProteusAI: An Open-Source and User-Friendly Platform for Machine Learning-Guided Protein Design and Engineering |
| 规范游戏：重新思考精准肿瘤学中药物反应预测的评估 |
Codice, F. |
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N/A |
The Specification Game: Rethinking the Evaluation of DrugResponse Prediction for Precision Oncology |
| scChat：基于大型语言模型的单细胞RNA测序分析上下文助手 |
Lu, Y.-C. |
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N/A |
scChat: A Large Language Model-Powered Co-Pilot for Contextualized Single-Cell RNA Sequencing Analysis |
| 比较分析Endoxifen、他莫昔芬和氟维司群：一种生物信息学方法揭示乳腺癌的作用机制 |
Remmel, H. L. |
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N/A |
Comparative analysis of Endoxifen, Tamoxifen and Fulvestrant: A Bioinformatics Approach to Uncover Mechanisms of Action in Breast Cancer |
| 使用5-氨基乙酰丙酸诱导的光敏化光动力疗法在获得性药物抗性的胰腺癌细胞中的疗效得到增强 |
Liu, Y. |
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N/A |
Efficacy of photodynamic therapy using 5-aminolevulinic acid-induced photosensitization is enhanced in pancreatic cancer cells with acquired drug resistance |
| 调节性T细胞通过淋巴毒素信号与肿瘤和内皮细胞进行交流。 |
Piao, W. |
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N/A |
Regulatory T cells crosstalk with tumor and endothelium through lymphotoxin signaling |
| Erbin通过与NHERF1和Ezrin相互作用，在HER2阳性乳腺癌中稳定膜ErbB2信号复合物。 |
JEONG, J. |
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Erbin interacts with NHERF1 and Ezrin to stabilize a membrane ErbB2 signaling complex in HER2-positive breast cancer |
| 在心脏和肌肉中实现强效且持久的基因调控，使用化学定义的siRNAs |
Fakih, H. H. |
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N/A |
Potent and durable gene modulation in heart and muscle with chemically defined siRNAs |
| 与槐叶苹共培养的水稻植株改变了根系结构和发育阶段的时机 |
Cannavo', S. |
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N/A |
Co-cultivating rice plants with Azolla filiculoides modifies root architecture and timing of developmental stages |
| 与满江红共培养对整株水稻代谢组的影响超出了传统无机氮肥的作用 |
Consorti, E. |
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N/A |
Co-cultivation with Azolla affects the metabolome of whole rice plant beyond canonical inorganic nitrogen fertilization |
| 细胞可塑性多步骤完成过程模型 |
Chen, C. M. |
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N/A |
A multi-step completion process model of cell plasticity |
| 揭示赤拟谷盗（Tribolium castaneum，Herbst, 1797）在小麦粉中的化学与行为生态学：面粉代谢成分的改变及化学信号在调节甲虫行为和调控种群增长中的作用。 |
Das, S. |
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N/A |
Unveiling the chemical and behavioural ecology of Tribolium castaneum (Herbst, 1797) in wheat flour: Alterations in flour metabolic content and the role of chemical cues in modulating beetles' behaviour and regulating population growth. |
| 从斑马鱼中获得的稳定初级脑细胞培养物显示，scn1lab突变体中的非神经元细胞出现过度增殖。 |
Odierna, L. |
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N/A |
Stable primary brain cell cultures from zebrafish reveal hyperproliferation of non-neuronal cells from scn1lab mutants |
| 细菌补充剂通过肠-脑轴减轻盆腔放疗引起的大脑代谢紊乱：一项多组学研究 |
Venkidesh, B. S. |
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N/A |
Bacterial Supplements Attenuate Pelvic Irradiation-Induced Brain Metabolic Disruptions via the Gut-Brain Axis: A Multi-Omics Investigation |
| 功能失调的LHX6苍白球-丘脑底核投射在小鼠Leigh综合征模型中介导癫痫发作 |
Sanchez-Benito, L. |
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N/A |
Dysfunctional LHX6 pallido-subthalamic projections mediate epileptic events in a mouse model of Leigh Syndrome |
| 设计实验方案以在受控实验室环境中引发警觉性变化 |
Zahran, S. |
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N/A |
Designing Experimental Protocols to Elicit Vigilance Variations in Controlled Laboratory Settings |
| 在PrP.TDP43-315 ALS模型中，采用组合方法治疗ALS；并发症与困境 |
Fromholt, S. |
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N/A |
A combinatorial approach to ALS therapies in the PrP.TDP43-315 model of ALS; complications and tribulations |
| 过滤点过程能够有效捕捉神经电生理记录中的节奏性和宽带功率谱结构 |
Bloniasz, P. F. |
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N/A |
Filtered Point Processes Tractably Capture Rhythmic And Broadband Power Spectral Structure in Neural Electrophysiological Recordings |
| 脑干神经元协调膀胱和尿道括约肌以进行排尿 |
Li, X. |
PDF |
N/A |
Brainstem neurons coordinate the bladder and urethra sphincter for urination |
| 病原体在微生物毒力和宿主抵抗力变化中的致病性 |
Gupta, A. |
PDF |
N/A |
Pathogenicity across variation in microbial virulence and host resistance |
| 表达嵌合细胞因子受体的巨噬细胞在IL-10或TGFβ刺激下表现出炎症表型并具有抗肿瘤活性。 |
Traxel, S. |
PDF |
N/A |
Macrophages expressing chimeric cytokine receptors have an inflammatory phenotype and anti-tumoral activity upon IL-10 or TGFβ stimulation |
| 通过多种丁酰胆碱酯酶激活Vγ9Vδ2 TCR的冷冻电镜结构洞察 |
Zhang, M. |
PDF |
N/A |
Cryo-EM structural insights into Vγ9Vδ2 TCR activation via multiple butyrophilins |
| TYK2抑制增强了Treg的分化和功能，同时防止了Th1和Th17的分化。 |
Tuomela, K. |
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N/A |
TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differnetiation |
| 第四代PDCD1驱动IL-10的CAR Tregs具有增强的抑制功能 |
Boardman, D. A. |
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N/A |
Fourth generation CAR Tregs with PDCD1-driven IL-10 have enhanced suppressive function |
| 发育中的人类肺部空间解析蓝图揭示了一种由WNT驱动微环境调控的基底细胞群体 |
Hsu, P. P. |
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N/A |
A spatially-resolved blueprint of the developing human lung reveals a basal cell population regulated by a WNT-driven niche |
| 在扁形动物的外上皮中，损伤诱导的转录对于组织再生至关重要。 |
Barai, P. |
PDF |
N/A |
Injury-induced transcription in the planarian outer epithelium is critical for tissue regeneration |
| 实验室进化的高温适应性大肠杆菌菌株的基因组分析 |
McGuire, B. E. |
PDF |
N/A |
Genomic analysis of laboratory-evolved, heat-adapted Escherichia coli strains |
| mRNA表达受非核仁RNA聚合酶I的共同调控。 |
Carter, L. M. |
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N/A |
mRNA expression is co-regulated by non-nucleolar RNA polymerase I |
| 通过scDEEP-mC实现的高覆盖度、等位基因解析的单细胞DNA甲基化分析揭示了细胞谱系、X染色体失活状态及复制动力学 |
Spix, N. J. |
PDF |
N/A |
High-coverage allele-resolved single-cell DNA methylation profiling by scDEEP-mC reveals cell lineage, X-inactivation state, and replication dynamics |
| 一种新型行为装置，用于在大鼠中进行自发探索和操作性条件下的社会信息空间条件化 |
Wise, T. B. |
PDF |
N/A |
A novel behavioral apparatus for spontaneous exploration and operant conditioning of social information under spatial conditions in rats |
| 利用人工智能衍生平台确定针对主动脉瓣肌成纤维细胞激活的药物组合中的性别差异 |
Vogt, B. J. |
PDF |
N/A |
Determining sex differences in drug combinations targeting aortic valve myofibroblast activation using an artificial intelligence derived platform |
| 一种低成本、开源的3D打印机，适用于多材料和高通量直接墨水书写软性和活体材料的打印。 |
Weiss, J. D. |
PDF |
N/A |
A low-cost, open-source 3D printer for multimaterial and high-throughput direct ink writing of soft and living materials |
| 数字光处理3D打印技术实现了高效的人工心脏组织制造，用于疾病模型构建 |
Dhand, A. P. |
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N/A |
Digital Light Processing 3D Printing enables High Throughput Fabrication of Human Engineered Heart Tissues for Disease Modeling |
| 工程化全肺用于组织生物学研究 |
Greaney, A. M. |
PDF |
N/A |
Engineered Whole Lungs for Tissue Biology |
| 纳米级可生物降解打印技术用于设计调节疫苗递送动力学 |
Peeler, D. J. |
PDF |
N/A |
Nanoscale biodegradable printing for designed tuneability of vaccine delivery kinetics |
| 针对蛋白酶降解的疫苗（PROTAVs）用于强效肿瘤联合免疫疗法 |
Wang, Q. |
PDF |
N/A |
Proteolysis-targeting vaccines (PROTAVs) for robust tumor combination immunotherapy |
| BioLLMNet：通过专用跨LLM转换网络增强RNA相互作用预测 |
Tahmid, M. T. |
PDF |
N/A |
BioLLMNet: Enhancing RNA-Interaction Prediction with a Specialized Cross-LLM Transformation Network |
| PertEval-scFM：基准测试单细胞基础模型用于扰动效应预测 |
Wenteler, A. |
PDF |
N/A |
PertEval-scFM: Benchmarking Single-Cell Foundation Models for Perturbation Effect Prediction |
| scMODAL：一种通用的深度学习框架，用于具有特征链接的综合单细胞多组学数据对齐 |
Wang, G. |
PDF |
N/A |
scMODAL: A general deep learning framework for comprehensive single-cell multi-omics data alignment with feature links |
| 临床和分子变异特性对变异效应预测工具的校准和性能的影响 |
Isakov, O. |
PDF |
N/A |
The Impact of Clinical and Molecular Variant Properties on Calibration and Performance of Variant Effect Prediction Tools |
| 心室心律失常综合征相关KCNJ2突变的原子级研究 |
Munawar, S. |
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N/A |
Atomic-Level Investigation of KCNJ2 Mutations Associated with Ventricular Arrhythmic Syndrome Phenotypes |
| 表型可塑性可以是对波动环境的一种进化反应。 |
Garcia-Galindo, P. |
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N/A |
Phenotypic plasticity can be an evolutionary response to fluctuating environments |
| CYP3A5抑制导致G1/S阻滞，并与CDK4/6抑制剂协同抑制前列腺癌细胞生长：减少健康差异的意义 |
Sharma, J. |
PDF |
N/A |
CYP3A5 inhibition causes G1/S blockade and synergizes with CDK4/6 inhibitor to suppress prostate cancer cell growth: Implications in reducing health disparity |
| 靶向FEN1以提高PARP抑制剂在三阴性乳腺癌中的疗效 |
Frederick, M. I. |
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N/A |
Targeting FEN1 to enhance efficacy of PARP inhibition in triple-negative breast cancer |
| 线粒体活性氧在肥厚型心肌病中引起心律失常 |
Kohlhaas, M. |
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N/A |
Mitochondrial reactive oxygen species cause arrhythmias in hypertrophic cardiomyopathy |
| 茄科中一个生物合成基因簇的亚功能化和表观遗传调控 |
Priego-Cubero, S. |
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N/A |
Sub-functionalization and epigenetic regulation of a biosynthetic gene cluster in Solanaceae |
| 脯氨酸-2'-脱氧麦根酸（PDMA）通过缓解石灰性碱性条件下大豆的缺铁症状，提高了种子质量和产量。 |
Kaya, Z. |
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N/A |
Proline-2'-deoxymugineic acid (PDMA) increases seed quality and yield by alleviating iron deficiency symptoms in soybean under calcareous-alkaline conditions |
| 异源性烟碱乙酰胆碱受体通过在运动和感觉整合位点传递GABA能信号来促进睡眠。 |
Yumita, T. |
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N/A |
A heteromeric nicotinic acetylcholine receptor promotes sleep by relaying GABAergic signals within a locus of motor and sensory integration |
| 通过抑制Notch信号通路实现感觉毛细胞的再生与前庭功能的恢复 |
Lahlou, H. |
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N/A |
Regeneration of Sensory Hair Cells and Restoration of Vestibular Function by Notch Inhibition |
| 边缘光谱估计 |
Patel, S. |
PDF |
N/A |
Spectral estimation at the edge |
| 性别在神经元对缺氧压力的反应中是否起作用？ |
Voogd, E. J. H. F. |
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N/A |
Does sex matter in neurons response to hypoxic stress? |
| 生理和损伤诱导的微胶质细胞动态变化贯穿整个生命周期 |
Tieu, T. |
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N/A |
Physiological and injury-induced microglial dynamics across the lifespan |
| 婴儿开放大脑：一个婴儿脑部分割的开源仓库 |
Feczko, E. J. |
PDF |
N/A |
Baby Open Brains: An Open-Source Repository of Infant Brain Segmentations |
| 下午至傍晚的明亮光线暴露会减少青少年晚些时候的褪黑素分泌。 |
Lazar, R. |
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N/A |
Afternoon to early evening bright light exposure reduces later melatonin production in adolescents |
| 短期热量限制或白藜芦醇补充剂改变了雄性和雌性大鼠的大规模脑网络连接 |
van Rooij, J. R. A. |
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N/A |
Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats |
| 使用雾化模式识别受体激动剂的免疫疗法可恢复严重免疫麻痹，并改善流感相关性肺曲霉病小鼠的预后。 |
Garcia, J. P. |
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N/A |
Immunotherapy with nebulized pattern recognition receptor agonists restores severe immune paralysis and improves outcomes in mice with influenza-associated pulmonary aspergillosis |
| 心肌炎和中性粒细胞介导的血管渗漏，而非细胞因子风暴，与致命的小鼠钩端螺旋体病相关。 |
Papadopoulos, S. |
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N/A |
Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosis |
| 果蝇腹部组织大小变化时的生长补偿 |
Ferreira, A. |
PDF |
N/A |
Growth compensation upon changes in tissue size in the Drosophila abdomen |
| 组织特异性转录组学揭示了专家幼鱼下颌差异背后的新颅面基因 |
Palominos, M. F. |
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N/A |
Tissue-specific transcriptomics uncovers novel craniofacial genes underlying jaw divergence in specialist pupfishes |
| 红砂岩表面微生物群落：尽管在分散限制和异质选择下分类学上存在差异，但功能趋同 |
Wang, B. |
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N/A |
Red sandstone surface microbiota: functional convergence despite taxonomic divergence under dispersal limitation and hetero selection |
| 热带北太平洋四种新型绿藻病毒的基因组多样性和全球分布 |
Bedi de Silva, A. |
PDF |
N/A |
Genomic diversity and global distribution of four new prasinoviruses from the tropical North Pacific |
| 硬蜱幼虫更喜欢含有伯氏疏螺旋体感染且皮质类固醇浓度较低的血液。 |
Vanroy, T. |
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N/A |
Ixodes ricinus nymphs prefer blood with Borrelia infection and low corticosteroid concentration |
| 放射虫的多样性与演化：超越海洋之星 |
Mendez Sandin, M. |
PDF |
N/A |
Diversity and evolution of Radiolaria: Beyond the stars of the ocean |
| 蛋白质-蛋白质相互作用塑造了遗传变异对蛋白质表达和复杂性状的反式调控影响 |
Li, J. |
PDF |
N/A |
Protein-protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits |
| 一个关于秀丽隐杆线虫RNAi遗传的遗传框架 |
Ketting, R. F. |
PDF |
N/A |
A genetic framework for RNAi inheritance in Caenorhabditis elegans |
| 铂金血统：一种用于基因变异的长读基准 |
Kronenberg, Z. |
PDF |
N/A |
The Platinum Pedigree: A long-read benchmark for genetic variants |
| 人乳头瘤病毒（HPV）相关宫颈上皮内瘤变组织的空间分析显示，与宫颈癌进展相关的独特免疫特征。 |
Pavilion, G. L. |
PDF |
N/A |
Spatial analysis of HPV associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression |
| 蝴蝶大脑在短暂接触信息素后，其形态和基因剪接模式会发生改变。 |
Dion, E. |
PDF |
N/A |
Butterfly brains change in morphology and in gene splicing patterns after brief pheromone exposure |
| 雄性和雌性小鼠在社会压力诱导的动机方面存在差异性变化 |
McGraw, M. |
PDF |
N/A |
Divergent changes in social stress-induced motivation in male and female mice |
| 海盗：掠夺AlphaFold预测以自动化蛋白质工程 |
Richardson, G. |
PDF |
N/A |
PIRATE: Plundering AlphaFold Predictions to Automate Protein Engineering |
| OpenExo：一款开源模块化外骨骼，用于增强人体功能 |
Williams, J. R. |
PDF |
N/A |
OpenExo: An Open-Source Modular Exoskeleton to Augment Human Function |
| 通过斜向光热显微镜实现的超灵敏活体红外光谱成像 |
Li, M. |
PDF |
N/A |
Ultrasensitive in vivo infrared spectroscopic imaging via oblique photothermal microscopy |
| 高通量形态筛选鉴定出化学定义的间充质基质细胞培养基，可增强细胞增殖并支持免疫调节功能的维持。 |
Spoerer, T. M. |
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N/A |
High Throughput Morphological Screening Identifies Chemically Defined Media for Mesenchymal Stromal Cells that Enhances Proliferation and Supports Maintenance of Immunomodulatory Function |
| 神经群体方差解释了学习过程中适应性差异 |
Stealey, H. M. |
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N/A |
Neural population variance explains adaptation differences during learning |
| 微孔板微加工：一种可定制的平台，支持微生理培养模型的原型设计、开发和测试 |
Reynolds, J. I. |
PDF |
N/A |
Microplate micromilling: A customizable platform to support the prototyping, development and testing of microphysiological culture models |
| 一项针对具有形态多样解剖结构的人类主动脉CT图像的U-Net三维图像分割研究 |
Chen, J. |
PDF |
N/A |
A 3D Image Segmentation Study of U-Net on CT Images of the Human Aorta with Morphologically Diverse Anatomy |
| 使用多模态神经网络在多频率谐波运动和B模式成像上进行自动肿瘤和FUS病灶量化 |
Hu, S. |
PDF |
N/A |
Automated Tumor and FUS Lesion Quantification on Multi-frequency Harmonic Motion and B-mode Imaging Using a Multi-modality Neural Network |
| 一种新的压缩策略，用于减小纳米孔测序数据的大小 |
Jayasooriya, K. |
PDF |
N/A |
A new compression strategy to reduce the size of nanopore sequencing data |
| EvoSeq-ML：借助进化信息引导的蛋白质序列表示与生成推进数据中心机器学习 |
Mardikoraem, M. |
PDF |
N/A |
EvoSeq-ML: Advancing Data-Centric Machine Learning with Evolutionary-Informed Protein Sequence Representation and Generation |
| 利用Spacedust在微生物基因组中发现保守基因簇的新方法 |
Zhang, R. |
PDF |
N/A |
De novo discovery of conserved gene clusters in microbial genomes with Spacedust |
| 用于冷冻电镜中鲁棒目标检测的新统计度量——2DTM |
Zhang, K. |
PDF |
N/A |
New Statistical Metric for Robust Target Detection in Cryo-EM Using 2DTM |
| 两栖动物saxiphilins结合和中和石房蛤毒素同系物的结构基础 |
Zakrzewska, S. |
PDF |
N/A |
Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins |
| 盐酸胍对胸腺α1和α-突触核蛋白形状的影响截然不同 |
Liu, Z. |
PDF |
N/A |
Impact of Guanidine Hydrochloride on the shapes of Prothymosin-α and α-Synuclein is dramatically different |
| 照亮根系-土壤力学 |
Le Houx, J. |
PDF |
N/A |
Illuminating root-soil mechanics |
| 使适配体更具抗体样特性：利用瓶刷聚合物偶联的适配体在体内靶向AXL |
Sun, T. |
PDF |
N/A |
Making Aptamers More Antibody-like: Targeting AXL in Vivo Using a Bottlebrush Polymer-Conjugated Aptamer |
| BoMBR：一个用于网状纤维分割的骨髓活检数据集 |
Raina, P. |
PDF |
N/A |
BoMBR: An Annotated Bone Marrow Biopsy Dataset for Segmentation of Reticulin Fibers |
| 黄瓜花叶病毒的sRNA调节症状影响桃蚜的取向和取食行为 |
Wrzesinska-Krupa, B. |
PDF |
N/A |
Symptom-modulating satRNAs of cucumoviruses affect the orientation and feeding behaviour of Myzus persicae |
| 癌胚蛋白Nogo-A通过VEGF-Notch-Hippo-代谢信号通路限制人源和鼠源胶质瘤的血管化和生长 |
Schwab, M. |
PDF |
N/A |
Onco-fetal protein Nogo-A restricts human and mouse glioma vascularization and growth via VEGF-Notch-hippo-metabolic signaling |
| 运动想象提高老年和年轻女性的力量控制能力 |
Calkins, C. A. |
PDF |
N/A |
Motor Imagery Improves Force Control in Older and Young Females |
| 大鼠下丘脑和未定带（Zona Incerta）的化学构筑研究。Chemopleth 1.0，一个可下载的交互式脑图空间数据库，包含五个可同时可视化的神经化学系统，并配备了新颖的特征和基于网格的映射工具。 |
Navarro, V. I. |
PDF |
N/A |
Chemoarchitectural studies of the rat hypothalamus and zona incerta.Chemopleth 1.0, a downloadable interactive Brain Maps spatial database of five co-visualizable neurochemical systems, with novel feature- and grid-based mapping tools |
| 通过无偏细胞类型分布聚类揭示的大脑结构组织 |
Munoz-Castaneda, R. |
PDF |
N/A |
Brain Structural Organization Revealed by Unbiased Cell-Type Distribution Clustering |
| 通过交叉验证多尺度多模态数据，重建小鼠大脑中单个神经元的连接组 |
Xiong, F. |
PDF |
N/A |
Reconstruct a Connectome of Single Neurons in Mouse Brains by Cross-Validating Multi-Scale Multi-Modality Data |
| 药物增强慢波活动可改善认知功能并减少阿尔茨海默病小鼠模型早期阶段的淀粉样病变。 |
Kollarik, S. |
PDF |
N/A |
Pharmacological enhancement of slow-wave activity improves cognition and reduces amyloidosis at an early stage in a mouse model of Alzheimer's disease |
| 自上而下的反馈很重要：类脑连接模式对视听整合的功能影响 |
Tugsbayar, M. |
PDF |
N/A |
Top-down feedback matters: Functional impact of brainlike connectivity motifs on audiovisual integration |
| 多实验室研究确立了在人工生态系统中进行植物微生物组研究的可靠方法 |
Novak, V. |
PDF |
N/A |
Multi-laboratory Study Establishes Reproducible Methods for Plant-Microbiome Research in Fabricated Ecosystems |
| 微小RNA和RNA结合蛋白介导的转录后调控对于早期胚胎细胞命运的决定至关重要。 |
Sangokoya, C. |
PDF |
N/A |
Coordinate post-transcriptional regulation by microRNAs and RNA binding proteins is critical for early embryonic cell fate decisions |
| 季节性接触和迁徙结构影响宽吻海豚的群体性流行病，并为疫情准备提供信息。 |
Collier, M. A. |
PDF |
N/A |
Seasonal contact and migration structure mass epidemics and inform outbreak preparedness in bottlenose dolphins |
| 干旱啮齿动物在转录组和基因组层面的趋同适应 |
Chalopin, D. |
PDF |
N/A |
Convergent transcriptomic and genomic adaptation in xeric rodents |
| 解开水损失与呼吸之间普遍权衡关系的塑料机制 |
Assis, B. A. |
PDF |
N/A |
Plastic mechanisms for unraveling a universal trade-off between water loss and respiration |
| G4mer：一种RNA语言模型，用于从群体规模的遗传数据中识别转录组范围内的G-四链体和疾病变异 |
Zhuang, F. |
PDF |
N/A |
G4mer: An RNA language model for transcriptome-wide identification of G-quadruplexes and disease variants from population-scale genetic data |
| 秀丽隐杆线虫的LON-1蛋白需要其CAP结构域来实现调节身体大小和BMP信号传导的功能。 |
Serrano, M. V. |
PDF |
N/A |
The C. elegans LON-1 protein requires its CAP domain for function in regulating body size and BMP signaling |
| 系统性实证评估个体碱基编辑靶点：验证USH2A中的治疗靶点及方法比较 |
Tachida, Y. |
PDF |
N/A |
Systematic empirical evaluation of individual base editing targets: validating therapeutic targets in USH2A and comparison of methods |
| 染色质模型比较与验证的挑战：来自第一届国际4D Nucleome黑客马拉松的项目 |
Kubica, J. |
PDF |
N/A |
The challenge of chromatin model comparison and validation a project from the first international 4D Nucleome Hackathon |
| 宿主基因组驱动虾微生物群的多样性、丰富性和有益微生物：一种全基因组视角。 |
Cornejo-Granados, F. |
PDF |
N/A |
Host Genome Drives the Diversity, Richness, and Beneficial Microbes in the Shrimp Microbiota: A Hologenome Perspective. |
| 人类血液白细胞成分在呼吸道病毒接种后反应的时间高分辨率图谱 |
Zhang, Y. |
PDF |
N/A |
Temporal High-Resolution Atlas of Human Blood Leukocyte Composition in Response to Respiratory Virus Inoculation |
| 多细胞生物中单细胞增强子活性的空间重建 |
Alberti, B. |
PDF |
N/A |
Spatial reconstruction of single-cell enhancer activity in a multicellular organism |
| 结合纳米液滴成像与超声定位显微技术用于检测脑内出血 |
LIN, B.-Z. |
PDF |
N/A |
Combined Nanodrops Imaging and Ultrasound Localization Microscopy for Detecting Intracerebral Hemorrhage |
| 支链氨基酸（BCAA）组装成有毒纤维丝可能与枫糖尿症（MSUD）的发病机制有关。 |
Kanth, C. P. |
PDF |
N/A |
Assembly of branched chain amino acid (BCAA) to toxic fibrils may be related to pathogenesis of Maple syrup urine disease (MSUD) |
| 基于级联向量化的化合物-蛋白质相互作用预测模型 |
Williams, G. |
PDF |
N/A |
A Predictive Model for Compound-Protein Interactions Based on Concatenated Vectorization |
| 消除病毒知识以实现安全且负责任地预测变异效果 |
Li, M. |
PDF |
N/A |
Unlearning Virus Knowledge Toward Safe and Responsible Mutation Effect Predictions |
| CellEKT：一种稳健的化学蛋白质组学工作流程，用于分析激酶抑制剂的细胞靶点参与情况 |
Ruegger, J. |
PDF |
N/A |
CellEKT: A robust chemical proteomics workflow to profile cellular target engagement of kinase inhibitors |
| 微小标签（Microbetag）：通过注释、富集测试和代谢互补分析简化微生物网络解释 |
Zafeiropoulos, H. |
PDF |
N/A |
microbetag: simplifying microbial network interpretation through annotation, enrichment tests and metabolic complementarity analysis |
| 从随机动力学和时空模式中学习机器学习稀疏反应扩散模型 |
Abubaker-Sharif, B. |
PDF |
N/A |
Machine learning sparse reaction-diffusion models from stochastic dynamics and spatiotemporal patterns |
| 遮荫对美国佛罗里达群岛加勒比海八放珊瑚Briareum asbestinum行为生态的影响 |
Draud, S. L. |
PDF |
N/A |
Influence of Shading on the Behavioral Ecology of a Caribbean Alcyonacean Octocoral, Briareum asbestinum, in the Florida Keys, United States |
| 利用碱性磷酸酶（AP）免疫标记方法研究fms样酪氨酸激酶3（FLT3）及其他神经元蛋白的细胞及亚细胞分布特征 |
Yin, Y. |
PDF |
N/A |
Characterization of the cellular and subcellular distribution of fms-like tyrosine kinase 3 (FLT3) and other neuronal proteins using an alkaline phosphatase (AP) immunolabeling method |
| 血清素增强神经发生生物标志物、海马体积和阿尔茨海默病中的认知功能 |
Azargoonjahromi, A. |
PDF |
N/A |
Serotonin Enhances Neurogenesis Biomarkers, Hippocampal Volumes, and Cognitive Functions in Alzheimer's Disease |
| 跨任务含义：海马事件边界反应如何预测无关的记忆表现 |
van Dijk, D. |
PDF |
N/A |
Cross-task implications: How hippocampal event boundary responses predict unrelated memory performance |
| 利用高扩散加权强度增强的结构脑连接分析 |
Yu, L. |
PDF |
N/A |
Enhanced Structural Brain Connectivity Analyses Using High Diffusion-weighting Strengths |
| 刺激历史，而非预期，驱动了哺乳动物大脑皮层中的感觉预测误差。 |
Westerberg, J. A. |
PDF |
N/A |
Stimulus history, not expectation, drives sensory prediction errors in mammalian cortex |
| Tbc1d15 在体内的敲低通过促进自噬减轻了 α-突触核蛋白诱导的神经毒性。 |
Siddiqi, F. H. |
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N/A |
Tbc1d15 knockdown in vivo alleviates α-synuclein-induced neurotoxicity by promoting autophagy. |
| 推进适应性细胞疗法：优化适应性自然杀伤细胞在实体瘤中的扩增 |
Almazan, N. M. |
PDF |
N/A |
Advancing Adoptive Cell Therapy: Optimized Expansion of Adaptive NK Cells for Solid Tumors |
| 在抗逆转录病毒治疗的人类免疫缺陷病毒（HIV）感染者中，结肠CD8+ T细胞中PPARγ的下调导致上皮屏障破坏。 |
Das Adhikari, U. |
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N/A |
PPARγ downregulation in colonic CD8+ T cells results in epithelial barrier disruption in people with HIV on antiretroviral therapy |
| IL-1β信号在人类淋巴组织中调节T滤泡辅助细胞和调节性T细胞 |
Vaineau, R. |
PDF |
N/A |
IL-1β Signaling Modulates T Follicular Helper and Regulatory Cells in Human Lymphoid Tissues |
| 通过宏基因组学洞察伊利湖中金属和抗生素抗性基因的时空变化 |
Reddy, S. |
PDF |
N/A |
Metagenomic Insights into the Spatio-temporal Variation of Metal and Antibiotic Resistance Genes in Lake Erie |
| 首个多用途的猫冠状病毒反向遗传系统 |
Kida, I. |
PDF |
N/A |
First versatile reverse genetics system for feline coronavirus |
| skalo：使用SKA分割k-mers与着色de Brujin图进行插入缺失基因分型 |
Derelle, R. |
PDF |
N/A |
skalo: using SKA split k-mers with coloured de Brujin graphs to genotype indels |
| 甘油提高了冷冻保存领鞭虫的存活率。 |
Chandra, S. |
PDF |
N/A |
Glycerol improves the viability of a cryopreserved choanoflagellate |
| 基于栖息地面积和状况的指标并不能很好地反映无脊椎动物的生物多样性。 |
Duffus, N. E. |
PDF |
N/A |
Metrics based on habitat area and condition are poor proxies for invertebrate biodiversity |
| 两种热带果蝇同时入侵沙漠环境中的差异与趋同性 |
Elsabrout, A. |
PDF |
N/A |
Divergence and parallelism in two tropical drosophilids simultaneously invading a desert environment |
| 雌性异配甲基组中的剂量补偿与性冲突 |
Tangili, M. |
PDF |
N/A |
Dosage compensation and sexual conflict in female heterogametic methylomes |
| 了解普通秋沙鸭的遗传多样性和系统地理学，及其在克什米尔喜马拉雅湿地中与其他水鸟物种的系统发育关系。 |
Ahmad, K. |
PDF |
N/A |
Understanding genetic diversity and phylogeography of Common Teal and its phylogenetic relationship with other water bird species in the wetlands of Kashmir Himalayas. |
| 爱德华兹珊瑚爱德华西亚·埃莱根斯的新基因组 |
Rutlekowski, A. |
PDF |
N/A |
De-novo Genome of the Edwardsiid anthozoan Edwardsia elegans |
| 解码胶原蛋白的热诱导展开和重折叠途径 |
Al-Shaer, A. |
PDF |
N/A |
Decoding Collagen's Thermally Induced Unfolding and Refolding Pathways |
| Cdv蛋白之间的相互作用层次结构驱动其招募至膜颈区域 |
De Franceschi, N. |
PDF |
N/A |
Interaction hierarchy among Cdv proteins drives recruitment to membrane necks |
| 整合可持续有机纳米酶与现场传感平台，实现农业与生物分子双重检测 |
Lee, D. H. |
PDF |
N/A |
Consolidated sustainable organic nanozyme integrated with Point-Of-Use sensing platform for dual agricultural and biological molecule detection |
| ChIPbinner：一个用于分析ChIP-Seq或CUT&RUN/TAG数据中在均匀窗口内分箱的广义组蛋白标记的R包 |
Padilla, R. |
PDF |
N/A |
ChIPbinner: An R package for analyzing broad histone marks binned in uniform windows from ChIP-Seq or CUT&RUN/TAG data |
| 空间多组学的马赛克整合与SpaMosaic |
Yan, X. |
PDF |
N/A |
Mosaic integration of spatial multi-omics with SpaMosaic |
| 全双曲神经网络：一种研究衰老轨迹的新方法 |
Ramirez, H. |
PDF |
N/A |
Fully Hyperbolic Neural Networks: A Novel Approach to Studying Aging Trajectories |
| 创建：通过离散嵌入识别细胞类型特异的顺式调控元件 |
Cui, X. |
PDF |
N/A |
CREATE: cell-type-specific cis-regulatory elements identification via discrete embedding |
| Gas1介导的肝母细胞瘤肿瘤发生抑制 |
Chen, K. |
PDF |
N/A |
Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis |
| BaMBo：一个用于分割任务的带注释骨髓活检数据集 |
Singh, A. |
PDF |
N/A |
BaMBo: An Annotated Bone Marrow Biopsy Dataset for Segmentation Task |
| GRIN2B疾病相关突变破坏了BK通道和NMDA受体信号纳米域的功能 |
Martinez-Lazaro, R. |
PDF |
N/A |
GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signalling nanodomains |
| 埃塞俄比亚中南部地区小麦叶枯病菌群体的遗传多样性 |
Tucho, A. |
PDF |
N/A |
Genetic Diversity of Zymoseptoria tritici Populations in Central and South-eastern Ethiopia |
| 可调节低速率的基因组重组与大肠杆菌中的Cre-lox系统：合成生物学和环境感知的通用工具 |
Garabello, E. |
PDF |
N/A |
Tunable Low-Rate Genomic Recombination with Cre-lox in E. coli: A Versatile Tool for Synthetic Biology and Environmental Sensing |
| 少突胶质细胞利用突触后蛋白来协调在不同神经递质类别的轴突上形成髓鞘。 |
Carey, N. |
PDF |
N/A |
Oligodendrocytes use post-synaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes |
| Fms样激酶3（FLT3）的药理学抑制促进了神经元的成熟并在小鼠模型中抑制了癫痫发作。 |
Cruite, K. |
PDF |
N/A |
Pharmacological inhibition of Fms-like kinase 3 (FLT3) promotes neuronal maturation and suppresses seizure in a mouse model |
| 脉冲神经网络的最优控制 |
Costa, T. |
PDF |
N/A |
Optimal control of spiking neural networks |
| 一种靶向膜的光开关在退化的视网膜中恢复了对光的生理开/关响应 |
Benfenati, F. |
PDF |
N/A |
A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina |
| Pannexin-2 缺陷的斑马鱼表现出眼部和视觉运动行为缺陷。 |
Shanbhag, R. |
PDF |
N/A |
Pannexin-2 deficient zebrafish develop ocular and visual motor behaviour defects |
| 一种用于相关分析的热塑性芯片，结合了免疫细胞反应的筛选与高分辨率成像 |
van Ooijen, H. |
PDF |
N/A |
A thermoplastic chip for correlative assays combining screening and high-resolution imaging of immune cell responses |
| 初始CD4+ T细胞库的异质性与可塑性 |
Sajani, A. |
PDF |
N/A |
Heterogeneity and plasticity of the naive CD4+ T cell compartment |
| 智利高盐湖中的后生动物多样性通过环境DNA被揭示 |
Sacco, M. |
PDF |
N/A |
Metazoan diversity in Chilean hypersaline lakes unveiled by environmental DNA |
| EDTA试管适用于在资源有限的环境中进行胰岛素和C肽的检测，并且可以在室温下保存长达24小时。 |
Nathan, M. |
PDF |
N/A |
EDTA tubes are suitable for insulin and C-peptide measurement in resource-limited settings and can be stored at room temperature for up to 24 hours |
| 衣藻中淀粉颗粒的形成不需要淀粉合酶4同工型。 |
COURSEAUX, A. |
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N/A |
Starch granule initiation doesnt require a starch synthase 4 isoform in Chlamydomonas reinhardtii. |
| 推进无创机械通气：模拟技术提升呼吸护理效果 |
Tahmid, M. T. |
PDF |
N/A |
Advancing Noninvasive Mechanical Ventilation:Simulating Techniques for Improved Respiratory Care |
| 情感调节障碍儿童的奖励加工 |
Aggensteiner, P. M. |
PDF |
N/A |
Reward processing in children with Affective Dysregulation |
| Theta-gamma经颅交流电刺激增强健康年轻和老年人的运动技能习得 |
Gamage, N. N. |
PDF |
N/A |
Theta-gamma transcranial alternating current stimulation enhances motor skill acquisition in healthy young and older adults |
| 中间神经元特化的命运可塑性 |
Mostajo-Radji, M. A. |
PDF |
N/A |
Fate plasticity of interneuron specification |
| 性别化的肠道和口腔微生物群变化：揭示胰腺癌中的性别特异性菌群失调 |
Khan, Z. A. |
PDF |
N/A |
Genderized Gut and Oral Microbiome Shifts: Uncovering Sex-Specific Dysbiosis in Pancreatic Cancer |
| 免疫肽组学助力结核分枝杆菌MHC-II抗原的发现与疫苗设计中的应用 |
Leddy, O. |
PDF |
N/A |
Immunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design |
| 肠道微生物对原发性硬化性胆管炎-炎症性肠病模型中结肠炎及结肠炎相关癌变的影响 |
Awoniyi, M. |
PDF |
N/A |
Gut Microbial Impact on Colitis and Colitis-Associated Carcinogenesis in a Primary Sclerosing Cholangitis-IBD Model |
| 构建一个社区驱动的生物信息学平台，以促进大麻（Cannabis sativa）多组学研究 |
Mansueto, L. |
PDF |
N/A |
Building a community-driven bioinformatics platform to facilitate Cannabis sativa multi-omics research |
| 一种改进的TEAD显性负性蛋白抑制剂，用于研究Hippo YAP1/TAZ依赖性转录。 |
Branch, B. |
PDF |
N/A |
An improved TEAD dominant-negative protein inhibitor to study Hippo YAP1/TAZ-dependent transcription. |
| CellStudio：一种模块化、可调节且易获取的平台，用于分析细胞培养中生长因子的分泌 |
Azuaje-Hualde, E. |
PDF |
N/A |
CellStudio: a Modular, Tunable and Accessible Platform for Analysis of Growth Factors Secretions in Cell Cultures |
| 蜂鸟上喙弯曲作为适应花蜜采食的进化特征 |
Rico-Guevara, A. |
PDF |
N/A |
Upper bill bending as an adaptation for nectar feeding in hummingbirds |
| STAMP：通过成像进行单细胞转录组分析和多模态表征 |
Pitino, E. |
PDF |
N/A |
STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging |
| 一个针对环境16S rRNA牛津纳米孔测序数据分析的优化参考数据库 |
Philip, M. |
PDF |
N/A |
A Targeted Reference Database for Improved Analysis of Environmental 16S rRNA Oxford Nanopore Sequencing Data |
| 实时时空追踪传染病在封闭环境中的爆发情况，采用宿主-病原体基于代理的系统 |
Srinivasan, S. |
PDF |
N/A |
Real-Time Spatiotemporal Tracking of Infectious Outbreaks in Confined Environments with a Host-Pathogen Agent-Based System |
| 模拟溶质回火2 |
Stratmann, D. |
PDF |
N/A |
Simulated Solute Tempering 2 |
| 血液生化改变及由北西埃塞俄比亚贡达ELFORA屠宰场宰杀绵羊的捻转血矛线虫病引起的病变特征 |
Malede, B. A. |
PDF |
N/A |
Haematobiochemical Alterations and Lesion Characterization Induced by Haemonchosis in Sheep Slaughtered at Gondar ELFORA Abattoir, North West Ethiopia |
| 在人类、动物和婴儿配方奶粉中检测钛纳米颗粒 |
Rivard, C. |
PDF |
N/A |
Detection of titanium nanoparticles in human, animal and infant formula milk |
| 饮食中的脂质主要沉积在皮肤中，并迅速影响其隔热性能。 |
Riley, N. |
PDF |
N/A |
Dietary lipid is largely deposited in skin and rapidly affects insulating properties |
| 揭示间充质干细胞外泌体中的miRNAs在慢性酒精摄入引起的神经炎症和行为障碍中的作用 |
Mellado, S. |
PDF |
N/A |
Unveiling the role of miRNAs from MSC-EVs in neuroinflammation and behavioral impairments induced by chronic alcohol consumption |
| 深度学习和分析模型在健康和精神分裂症的大脑结构-功能关系上给出了不同的结果。 |
Cai, Q. |
PDF |
N/A |
Deep-learning and analytical models give distinct results for the brain structure-function relationship in health and in psychosis |
| HBN-EEG：健康大脑网络（HBN）脑电图数据集的FAIR实现 |
Shirazi, S. Y. |
PDF |
N/A |
HBN-EEG: The FAIR implementation of the Healthy Brain Network (HBN) electroencephalography dataset |
| 探索脑机接口中深度学习与可解释模型之间的权衡 |
Cubillos, L. H. |
PDF |
N/A |
Exploring the trade-off between deep-learning and explainable models for brain-machine interfaces |
| 内质网相关受体SorCS1-3的胞内结构域中存在一个三丝氨酸基序，该基序调控神经营养活性。 |
Dalby, A. |
PDF |
N/A |
A triple serine motif in the intracellular domains of sortilin-related receptors SorCS1-3 regulates neurotrophic activity |
| 通过混合前额叶皮层资源实现动态注意力控制 |
Di Bello, F. |
PDF |
N/A |
Dynamic Attentional Control Through Mixed Prefrontal Cortex Resources |
| 血清蛋白质组学揭示了通过追踪SARS-CoV2混合免疫对关注变异的高亲和力和趋同抗体 |
Patel, A. |
PDF |
N/A |
Serum proteomics reveals high-affinity and convergent antibodies by tracking SARS-CoV2 hybrid immunity to emerging variants of concern |
| 加纳大塔马利都市区牛、牛肉及人类中沙门氏菌肠炎的基因组分析 |
Sunmonu, G. T. |
PDF |
N/A |
Genomic Analysis of Salmonella enterica from cattle, beef and humans in the Greater Tamale Metropolis of Ghana |
| 人类星状病毒感染的新型小鼠模型揭示了其对心血管系统的趋向性 |
Owen, M. C. |
PDF |
N/A |
Novel murine model of human astrovirus infection reveals a cardiovascular tropism |
| 微重力和低量缪子辐射影响秀丽隐杆线虫中的病毒致病性和生理学 |
Villena-Gimenez, A. |
PDF |
N/A |
Microgravity and low muon radiation affect viral pathogenesis and physiology in Caenorhabditis elegans |
| 检测自北方短尾鼩（Blarina brevicauda）的新型副亨尼帕病毒 |
Imai, S. |
PDF |
N/A |
Detection of a novel parahenipavirus from northern short-tailed shrews (Blarina brevicauda ) |
| 延迟的病毒清除和改变的炎症反应导致老年小鼠SARS-CoV-2感染的严重性增加。 |
Lacasse, E. |
PDF |
N/A |
Delayed viral clearance and altered inflammatory responses resulted in increased severity of SARS-CoV-2 infection in aged mice. |
| 一种具有分离活性的双功能snoRNA，能够指导rRNA的2'-O-甲基化并作为配子发生效应器的支架 |
Leroy, E. |
PDF |
N/A |
A bifunctional snoRNA with separable activities in guiding rRNA 2'-O-methylation and scaffolding gametogenesis effectors |
| 脂肪酸去饱和作用指导细胞在铁死亡和细胞衰老之间的决策 |
Kuehnemann, C. |
PDF |
N/A |
Fatty acid desaturation guides cellular decisions between ferroptosis and cellular senescence |
| 衰老肌肉中肌原纤维大小、形状和网络连接的变化 |
Ajayi, P. T. |
PDF |
N/A |
Changes in Myofibril Size, Shape, and Network Connectivity in Aging Muscle |
| 在再生过程中，VEGF信号在非血管组织的扩展中发挥着进化上保守的作用。 |
Savage, A. M. |
PDF |
N/A |
An evolutionarily conserved role for VEGF signaling in the expansion of non-vascular tissue during regeneration. |
| 使用光谱流式细胞术对全细胞中核组蛋白H3的翻译后修饰进行分析 |
Golden, C. S. |
PDF |
N/A |
Nuclear Histone H3 Post-translational Modification Profiling in Whole Cells using Spectral Flow Cytometry |
| 大豆锈病菌（Phakopsora pachyrhizi）的遗传多样性主要由两个主要的进化谱系所驱动。 |
Rocha, V. D. d. |
PDF |
N/A |
The genetic diversity of the soybean rust pathogen Phakopsora pachyrhizi has been driven by two major evolutionary lineages |
| 基因与环境相互作用及美洲小鼠适应性体型变异 |
Mack, K. L. |
PDF |
N/A |
Gene-by-environment interactions and adaptive body size variation in mice from the Americas |
| 蚂蚁嗅觉系统的祖先复杂性和受限多样化 |
Marty, S. |
PDF |
N/A |
Ancestral complexity and constrained diversification of the ant olfactory system |
| 辐鳍鱼类非视觉和视觉视蛋白基因谱系的演化 |
Policarpo, M. |
PDF |
N/A |
Evolution of the non-visual and visual opsin gene repertoire in ray-finned fishes |
| 性选择在遗传拯救中起着重要作用，但生产力的益处会随着时间而减弱；一项多代实验为保护工作提供信息。 |
West, G. |
PDF |
N/A |
Sexual selection matters in genetic rescue, but productivity benefits fade over time; a multi-generation experiment to inform conservation. |
| 性别和遗传背景影响混合大鼠多样性面板中的静脉注射羟考酮自我给药 |
Duffy, E. P. |
PDF |
N/A |
Sex and genetic background influence intravenous oxycodone self-administration in the Hybrid Rat Diversity Panel |
| 锥虫线粒体基因组分离复合体永久性外-内膜接触位点的分子特征 |
Stettler, P. |
PDF |
N/A |
Molecular characterization of the permanent outer-inner membrane contact site of the mitochondrial genome segregation complex in trypanosomes |
| MDA5变异体对自身免疫性疾病保护作用的分子基础 |
Singh, R. |
PDF |
N/A |
Molecular basis of autoimmune disease protection by MDA5 variants |
| 使用小分子方法对RNA鸟嘌呤-7甲基转移酶（RNMT）进行表征 |
Pearson, L.-A. |
PDF |
N/A |
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach |
| 具有序列控制骨架的瓶刷聚合物，用于增强寡核苷酸递送 |
Wei, Y. |
PDF |
N/A |
Bottlebrush polymers with sequence-controlled backbones for enhanced oligonucleotide delivery |
| PoreMeth2：利用纳米孔测序解码甲基化组变化的演化 |
Mattei, G. |
PDF |
N/A |
PoreMeth2: decoding the evolution of methylome alterations with Nanopore sequencing |
| HLAIIPred：用于建模HLA II类分子与肽段相互作用的交叉注意力机制 |
Haghighatlari, M. |
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N/A |
HLAIIPred: Cross-Attention Mechanism for Modeling the Interaction of HLA Class II Molecules with Peptides |
| PUNCH2：探索内在无序蛋白质预测器的策略 |
Meng, D. |
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N/A |
PUNCH2: explore the strategy for Intrinsically Disordered Protein predictor |
| Tannin1（高粱中拟南芥主调控因子TTG1的直系同源基因）的多效性调控功能丧失 |
Schuh, A. |
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N/A |
Loss of pleiotropic regulatory functions in Tannin1, the sorghum ortholog of Arabidopsis master regulator TTG1 |
| 估算英格兰西南部野生鹿群中结核病（牛分枝杆菌）感染的抗体流行率 |
Jinks, R. |
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N/A |
Estimating the seroprevalence of tuberculosis (Mycobacterium bovis) infection in a wild deer population in southwest England |
| 摆脱单个神经元的束缚：神经元在神经元集合中的选择性发生变化，其重构是动态编码的基础。 |
Londei, F. |
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N/A |
Out of the single-neuron straitjacket: neurons within assemblies change selectivity and their reconfiguration underlies dynamic coding |
| 在转基因小鼠模型中限制听力损失 |
Babola, T. A. |
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N/A |
Limiting hearing loss in transgenic mouse models |
| 升高的NAD+通过Sir2A介导的GCβ去乙酰化和OES定位，促进疟原虫卵形体的滑行运动和蚊媒感染 |
Shi, Y. |
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N/A |
Elevated NAD+ drives Sir2A-mediated GCβ deacetylation and OES localization for Plasmodium ookinete gliding and mosquito infection |
| 肺上皮细胞稳态和免疫失调加剧了中东呼吸综合征冠状病毒疾病的严重性 |
Sheahan, T. P. |
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N/A |
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severity |
| 外显子转录组rRNA指纹分析揭示了组织来源和肿瘤特异性特征 |
Milenkovic, I. |
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N/A |
Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures |
| UBR4调控依赖于MetAP2的精氨酸/N-降解途径 |
Morrison, E. J. |
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N/A |
UBR4 regulates a MetAP2-dependent Arg/N-degron pathway |
| TECPR2是一种Rab5效应器，调控内吞体货物再循环。 |
Paul, S. |
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TECPR2 is a Rab5 effector that regulates endosomal cargo recycling |
| 脂滴靶向ABHD5和PNPLA3 I148M是促进肝脏脂肪变性所必需的 |
Teskey, G. |
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Lipid Droplet Targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosis |
| 同时测量总氧进化和基础光合作用氧化还原反应：以蓝细菌为例的研究 |
Liran, O. |
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N/A |
Simultaneous Measurement of Gross Oxygen Evolution and Underlying Photosynthetic Redox Reactions: A Case Study Using Cyanobacteria |
| DYRK1A激酶三倍体是唐氏综合征中中耳炎的主要病因。 |
Tateossian, H. |
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N/A |
DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome |
| 具有改变的RNA结合和降解活性的病理性PNPase变体影响细菌和人类细胞模型的表型。 |
Pizzoccheri, R. |
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Pathological PNPase variants with altered RNA binding and degradation activity affect the phenotype of bacterial and human cell models |
| 通过13个物种的基因组和功能注释进行长链非编码RNA（lncRNA）的跨物种直系同源检测。 |
Degalez, F. |
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Cross-species orthology detection of long non-coding RNAs (lncRNA) through 13 species using genomic and functional annotations. |
| 使用ONT R10.4.1长读长测序技术对三种主要呼吸道细菌病原体进行精确基因分型 |
Zidane, N. |
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N/A |
Accurate genotyping of three major respiratory bacterial pathogens with ONT R10.4.1 long-read sequencing |
| 使用蛋白质语言模型进行单序列、无结构的变构残基预测 |
Kannan, G. R. |
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N/A |
Single-Sequence, Structure Free Allosteric Residue Prediction with Protein Language Models |
| 高盐极端微生物核糖体分析中微球菌核酸酶（MNase）的纯化 |
Gregorova, P. |
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Purification of micrococcal nuclease (MNase) for use in ribosomal profiling of high-salinity extremophiles |
| 揭示肽核酸作为Riboglow RNA成像平台功能连接体的潜力 |
Wierzba, A. J. |
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Unveiling the Promise of Peptide Nucleic Acids as Functional Linkers for Riboglow RNA Imaging Platform |
| 表面非对称机械阻抗下步行的前向模拟：步态康复的启示 |
Abdikadirova, B. |
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N/A |
Forward Simulations of Walking on Surfaces with Asymmetric Mechanical Impedance: Insights for Gait Rehabilitation |
| 蛋白质语言模型的适应性取决于偏好 |
Gordon, C. |
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N/A |
Protein Language Model Fitness Is a Matter of Preference |
| LIET模型：捕捉从加载到终止的RNA聚合酶动力学 |
Stanley, J. T. |
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N/A |
LIET Model: Capturing the kinetics of RNA polymerase from loading to termination |
| 在重构系统中20种氨酰-tRNA合成酶的可持续再生，迈向自合成人工系统 |
Hagino, K. |
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Sustainable Regeneration of 20 Aminoacyl-tRNA Synthetases in a Reconstituted System Toward Self-Synthesizing Artificial Systems |
| 高通量优化基于纸张的无细胞生物传感器 |
Garcia, D. C. |
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N/A |
High-Throughput Optimization of Paper-Based Cell-Free Biosensors |
| 巨细胞病毒通过核输出宿主限制因子DDX41来限制先天免疫反应 |
Baruah, V. |
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Cytomegalovirus Restricts the Innate Immune Response by Nuclear Export of Host Restriction Factor DDX41 |
| 通过整合系统发育信息，从微生物基因组中改进最大生长速率预测 |
Xu, L. |
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N/A |
Improved maximum growth rate prediction from microbial genomes by integrating phylogenetic information |
| 在丁香假单胞菌中，IS5元件的独立、持续的支系特异性扩张 |
Baltrus, D. A. |
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Independent, Ongoing Clade-Specific Expansions of IS5 Elements in Pseudomonas syringae |
| 微生物群落的稳定性与珊瑚的热耐受性相关 |
Baquiran, J. I. P. |
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N/A |
Microbiome stability is linked to coral thermotolerance |
| 含水层微生物群落在热砷迁移作用下表现出高度变异性。 |
Chen, M. |
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N/A |
Aquifer microbial communities are highly variable in response to thermal arsenic mobilization |
| 通过光在哺乳动物细胞中表达生物治疗药物的强效光开关 |
Gebel, J. |
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N/A |
Potent photoswitch for expression of biotherapeutics in mammalian cells by light |
| 百年博物馆标本病毒宏基因组学揭示了RNA的长期稳定性 |
Keene, A. H. |
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Viral metagenomics of 100-year-old museum specimens highlights the long-term stability of RNA |
| 考察早期儿童功能性和结构性脑网络架构、年龄与注意力技能之间的关系 |
Rokos, L. |
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Examining Relationships between Functional and Structural Brain Network Architecture, Age, and Attention Skills in Early Childhood |
| 引导视觉搜索与早期视觉皮层中的基于特征的优先图相关联。 |
Duecker, K. |
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Guided Visual Search is associated with a feature-based priority map in early visual cortex |
| 语义维度支持物体记忆性的皮层表征 |
Slayton, M. A. |
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N/A |
Semantic Dimensions Support the Cortical Representation of Object Memorability |
| 母亲-儿童互动中的同步性：神经与运动耦合作为学龄前儿童运动学习与发展的机制 |
Nagy, P. |
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N/A |
Interpersonal Synchronization in Mother-Child Dyads: Neural and Motor Coupling as a Mechanism for Motor Learning and Development in Preschoolers |
| 皮层中间神经元对浅层感觉处理的可靠性受行为状态的调节 |
Sweeney, C. G. |
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N/A |
Reliable sensory processing of superficial cortical interneurons is modulated by behavioral state |
| 细胞类型特异的投射模式促进皮层微电路中的平衡活动 |
Kurth, A. C. |
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N/A |
Cell-type specific projection patterns promote balanced activity in cortical microcircuits |