| 如何利用转录组数据进行癌症细胞治疗诱导抗性的博弈论建模？基于患者来源的胶质母细胞瘤类器官的案例研究 |
Spekking, L. |
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How to use transcriptomic data for game-theoretic modeling of treatment-induced resistance in cancer cells? A case study in patient-derived glioblastoma organoids |
| 树突生长和突触组织受活动无关的线索和局部活动依赖性可塑性的调控。 |
Kirchner, J. H. |
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Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity |
| 依赖于SAM的病毒MTase抑制剂：汉黄芩素和咖啡酸苯乙酯，对登革热MTase的结构洞察 |
Bhutkar, M. |
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SAM-dependent viral MTase inhibitors: herbacetin and caffeic acid phenethyl ester, structural insights into dengue MTase |
| 控制有限感知决策 |
Castineiras de Saa, J. R. |
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Control Limited Perceptual Decision Making |
| 新皮层电路振荡动力学的功能作用：一种计算视角 |
Effenberger, F. |
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The functional role of oscillatory dynamics of neocortical circuits: a computational perspective |
| 基底外侧杏仁核振荡在生物物理模型中实现恐惧学习 |
Cattani, A. |
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Basolateral amygdala oscillations enable fear learning in a biophysical model |
| 液-液界面限制能够再现体内中性粒细胞的形变，并引发基于囊泡的迁移。 |
Schrope, J. H. |
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Confinement by liquid-liquid interface replicates in vivo neutrophil deformations and elicits bleb based migration |
| 大规模皮层网络以结构化的循环方式组织。 |
van Es, M. W. J. |
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Large-scale cortical networks are organized in structured cycles |
| 通过脑桥网状结构进行运动控制的皮层-皮层下回路 |
Bosz, E. |
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A cortico-subcortical loop for motor control via the pontine reticular formation |
| 对小鼠集合淋巴管的细胞成分进行表征，结果显示淋巴肌肉细胞是调节淋巴收缩的固有起搏细胞。 |
Zawieja, S. D. |
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Characterization of the cellular components of mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells regulating lymphatic contractions |
| NPYR介导的调制是经验依赖性、性二态学习的基础 |
Peedikayil-Kurien, S. |
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Modulation by NPYR underlies experience-dependent, sexually dimorphic learning |
| 胰岛素和运动诱导的人类骨骼肌磷酸蛋白质组学研究揭示REPS1为肌肉葡萄糖摄取的新调控因子 |
Kjaergaard, J. |
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Insulin and Exercise-induced Phosphoproteomics of Human Skeletal Muscle Identify REPS1 as a New Regulator of Muscle Glucose Uptake |
| 撤回：飞蝗在躲避碰撞行为中的飞行肌协调与身体方向变化 |
Manchester, C. W. |
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WITHDRAWN: Flight muscle coordination and body orientation changes of Locusta migratoria during collision avoidance behaviour |
| 利用大型语言模型揭示人脑中的多层次和多模态语义表征 |
Nakagi, Y. |
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Unveiling Multi-level and Multi-modal Semantic Representations in the Human Brain using Large Language Models |
| 人类在自然噪声中对语音识别的敏感性，其基础在于中等水平声音统计的干扰。 |
Clonan, A. C. |
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Interference of mid-level sound statistics underlie human speech recognition sensitivity in natural noise |
| ADAMTS7促进动脉粥样硬化中的平滑肌泡沫细胞扩张 |
Chung, A. |
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ADAMTS7 Promotes Smooth Muscle Foam Cell Expansion in Atherosclerosis |
| 肝细胞RIPK1在代谢挑战期间维持肝脏稳态的作用 |
Zhang, W. |
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Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges |
| 多媒体：微生物组数据的多元中介分析 |
Jiang, H. |
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multimedia: Multimodal Mediation Analysis of Microbiome Data |
| 一项全基因组CRISPR筛选揭示了内体成熟蛋白WDR91作为黑色素瘤中有效ASO活性的促进因子 |
Menchon, G. |
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A Genome-wide CRISPR screen unveils the endosomal maturation protein WDR91 as a promoter of productive ASO activity in melanoma |
| 侧嗅皮层功能障碍在阿尔茨海默病小鼠中的表现 |
Raghuraman, R. |
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Lateral Entorhinal Cortex Dysfunction in Alzheimer's Disease Mice |
| 时空变换器用于解码神经运动控制 |
Candelori, B. |
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Spatio-temporal transformers for decoding neural movement control |
| 双层图学习揭示了乳腺癌多重数字病理学中与预后相关的肿瘤微环境模式 |
Wang, Z. |
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Bi-level Graph Learning Unveils Prognosis-Relevant Tumor Microenvironment Patterns in Breast Multiplexed Digital Pathology |
| 硅藻光系统I超复合物中岩藻黄素叶绿素a/c结合蛋白分子组装的结构基础 |
Kato, K. |
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Structural basis for molecular assembly of fucoxanthin chlorophyll a/c-binding proteins in a diatom photosystem I supercomplex |
| 青少年时期，大血管血流与微血管脑血管反应性在区域上是相互关联的。 |
Zvolanek, K. M. |
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Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence |
| 小鼠感染拉科罗斯病毒后，中和抗体、细胞因子和趋化因子的年龄特异性动态变化 |
Alatrash, R. |
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Age-specific dynamics of neutralizing antibodies, cytokines, and chemokines in response to La Crosse virus infection in mice |
| 胎盘疟疾引发独特的甲基化模式，与胎儿生长受限相关 |
Ozarslan, N. |
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Placental Malaria Induces a Unique Methylation Profile Associated with Fetal Growth Restriction |
| 基于模型的力信号反卷积以估计在低、中和高力等长收缩下的运动单位抽搐参数 |
Rohlen, R. |
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Model-based deconvolution of a force signal to estimate motor unit twitch parameters under low, moderate and high force isometric contractions |
| 线粒体的动态变化支持了小胶质细胞表型的灵活性 |
Espinoza, K. |
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Dynamic changes in mitochondria support phenotypic flexibility of microglia |
| 元控制需求会抑制认知控制区域 |
Akgur, B. F. |
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Meta-Control Demands Deactivate Cognitive-Control Regions |
| 响应红光的Cre重组酶用于细菌的光遗传学 |
Jafarbeglou, F. |
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Red light responsive Cre recombinase for bacterial optogenetics |
| 蜂鸟传粉和自花传粉的猴面花（Mimulus）物种之间花部性状分化的遗传结构 |
Chen, H. |
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The genetic architecture of floral trait divergence between hummingbird- and self-pollinated monkeyflower (Mimulus) species |
| 不同的多巴胺能脉冲时序依赖可塑性规则适合不同的功能角色 |
Sosis, B. |
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Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles |
| 左半球对元音的衰减处理预测了自闭症儿童在噪音环境中的语音感知缺陷 |
Fadeev, K. A. |
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Attenuated processing of vowels in the left hemisphere predicts speech-in-noise perception deficit in children with autism |
| 非遍历性和辛普森悖论在认知控制神经认知动力学中的体现 |
Mistry, P. K. |
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Nonergodicity and Simpson's paradox in neurocognitive dynamics of cognitive control |
| PA28γ通过提升线粒体功能，促进肿瘤的恶性进展，这一过程依赖于C1QBP。 |
Wang, J. |
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PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP |
| 在坦桑尼亚南部的一个下放野生动物管理区内，围绕授权渔业定居点建立了一个有效的社区保护模式。 |
Duggan, L. M. |
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An effective model for community-based conservation around authorized fishing settlements inside a devolved Wildlife Management Area in southern Tanzania |
| 通过Cre/loxP系统快速体外组装并转移DNA片段至JCVI-syn3B最小合成细菌基因组的方法 |
Uenoyama, A. |
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Rapid in vitro method to assemble and transfer DNA fragments into the JCVI-syn3B minimal synthetic bacterial genome through Cre/loxP system |
| 儿童中枢神经系统肿瘤中异常剪接的特征分析揭示CLK1为候选致癌依赖基因 |
Naqvi, A. S. |
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Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency |
| 局部横向连接足以在深度神经网络中复制类似皮层的拓扑组织 |
Qian, X. |
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Local lateral connectivity is sufficient for replicating cortex-like topographical organization in deep neural networks |
| 循环网络中的状态表示学习：随机反馈和生物约束的力量 |
Tsurumi, T. |
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Learning of state representation in recurrent network: the power of random feedback and biological constraints |
| CRISP：相关性优化图像分割过程 |
Briggs, J. |
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CRISP: Correlation-Refined Image Segmentation Process |
| 确定抗生素的脱靶活性以及线粒体中新颖的翻译起始位点 |
Marks, J. |
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Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria |
| 揭示CRBN分子胶水隐藏的相互作用组：化学蛋白质组学研究 |
Baek, K. |
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Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics |
| 性发育、生长发育和营养依赖的大西洋鲑鱼主要成熟年龄基因表达 |
Asheim, E. R. |
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Sex-, development-, and nutrition-dependent expression of a major age-at-maturity gene in Atlantic salmon |
| 量化生物研究中条形图的数据失真 |
Lin, T.-J. |
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Quantifying Data Distortion in Bar Graphs in Biological Research |
| 光质信号的整合调控了幼苗建立过程中ABA含量和气孔运动 |
Gustavsson, M. |
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Integration of light quality signals regulates ABA abundance and stomatal movements during seedling establishment |
| 特定的序列特征会导致在检测多态性转座子插入时出现偏差。 |
Verneret, M. |
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Particular sequence characteristics induce bias in the detection of polymorphic transposable element insertions |
| 电磁刺激各向异性水凝胶用于引导神经形态发生 |
Jensen, B. N. |
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Electromagnetic Stimulated Anisotropic Hydrogels for Guided Neuronal Morphogenesis |
| CXXC指蛋白1与FOXP3相互作用，以稳定调节性T细胞的内稳态和抑制功能 |
Meng, X. |
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CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells |
| 鉴定与先天性心脏病中临床报告的CNV相关的长链非编码RNA候选疾病基因 |
Penaloza, J. S. |
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Identification of Long Non-coding RNA Candidate Disease Genes Associated with Clinically Reported CNVs in Congenital Heart Disease |
| 与满江红共培养对整株水稻代谢组的影响超越了传统无机氮肥的作用 |
Consorti, E. |
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Co-cultivation with Azolla affects the metabolome of whole rice plant beyond canonical inorganic nitrogen fertilization |
| 发育中的人类肺部空间解析蓝图揭示了一种由WNT驱动微环境调控的基底细胞群体 |
Hsu, P. P. |
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A spatially-resolved blueprint of the developing human lung reveals a basal cell population regulated by a WNT-driven niche |
| 一个针对环境16S rRNA牛津纳米孔测序数据分析的优化参考数据库 |
Philip, M. |
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A Targeted Reference Database for Improved Analysis of Environmental 16S rRNA Oxford Nanopore Sequencing Data |
| 在重构系统中20种氨酰-tRNA合成酶的可持续再生：迈向自合成人工系统的研究 |
Hagino, K. |
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Sustainable Regeneration of 20 Aminoacyl-tRNA Synthetases in a Reconstituted System Toward Self-Synthesizing Artificial Systems |
| 拟南芥RNA结合蛋白SGS3被招募到染色质重塑因子CHR11上，以促进从蛋白质编码基因中产生小干扰RNA（siRNA）。 |
Elmayan, T. |
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The Arabidopsis RNA-binding protein SGS3 is recruited to the chromatin remodeler CHR11 to promote siRNA production from protein-coding genes |
| 早期转移过程中力学生物学信号对骨细胞的调控驱动后续的骨质溶解：一个计算力学调控框架的预测 |
Verbruggen, A. S. K. |
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Mechanobiological cues to bone cells during early metastasis drive later osteolysis: a computational mechanoregulation framework prediction |
| 常规经颅直流电刺激（tDCS）和高清晰度经颅直流电刺激（HD-tDCS）对小脑的偏移镇痛作用的差异效应 |
O'Connor, N. |
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Differential effects of conventional transcranial direct current stimulation (tDCS) and high-definition transcranial direct current stimulation (HD-tDCS) of the cerebellum on offset analgesia |
| Meta2DB：为健康状态预测而精选的鸟枪法宏基因组特征集及元数据 |
Kok, C. R. |
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Meta2DB: Curated Shotgun Metagenomic Feature Sets and Metadata for Health State Prediction |
| 单脉冲和成对脉冲经颅磁刺激在人类近中央皮质中激活了空间上不同的皮质运动表征 |
Madsen, M. A. J. |
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Single and paired TMS pulses engage spatially distinct corticomotor representations in human pericentral cortex |
| 口服暴露于牛奶巴氏灭菌的HPAI H5N1对小鼠免疫反应和死亡率的影响 |
Brigleb, P. H. |
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Effects of Oral Exposure to HPAI H5N1 Pasteurized in Milk on Immune Response and Mortality in Mice |
| 一种利用生物层干涉技术测量纳米抗体结合动力学及基于竞争的表位定位的有效方法 |
Bates, T. A. |
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An effective method of measuring nanobody binding kinetics and competition-based epitope mapping using biolayer interferometry |
| 氧化应激与心血管疾病中钙调节蛋白关联的数据驱动性见解。 |
Panday, N. |
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Data-driven insights into the association between oxidative stress and calcium-regulating proteins in cardiovascular disease. |
| 三维重建技术实现了高效的大规模表型分析和叶序的定量遗传学研究。 |
Davis, J. M. |
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3D Reconstruction Enables High-Throughput Phenotyping and Quantitative Genetic Analysis of Phyllotaxy |
| 通过拓扑高阶功能连接揭示精神分裂症中的整合-分离失衡 |
Li, Q. |
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Unraveling Integration-Segregation Imbalances in Schizophrenia Through Topological High-Order Functional Connectivity |
| 决策信心与结果变异性最佳调控超参数设置的不同方面 |
Desender, K. |
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Decision Confidence and Outcome Variability Optimally Regulate Separate Aspects of Hyperparameter Setting |
| 双语能力调节学龄前儿童执行功能发展：一项初步研究 |
Sade, S. |
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Bilingualism Modulates Executive Function Development in Pre-School Aged Children: A Preliminary Study |
| 欧洲积极自然未来的叙事 |
D'Alessio, A. |
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Narratives for positive nature futures in Europe |
| 分泌的精胺合成酶揭示了PGC1a诱导的前列腺癌生长抑制的旁分泌作用 |
Schaub Clarigue, A. |
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Secreted spermidine synthase reveals a paracrine role for PGC1a-induced growth suppression in prostate cancer |
| 自愿的预扫视注意和非自愿的外源性注意对对比度外观的相同双向调制 |
Zhang, T. |
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Same bi-directional modulation of contrast appearance for voluntary presaccadic attention and involuntary exogenous attention |
| 前额叶皮层的不规则神经兴奋可以抵消与年龄相关的海马体θ活动在空间记忆维持中的减少。 |
Park, S.-E. |
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Aperiodic neural excitation of the prefrontal cortex offsets age-related decrease in hippocampal theta activity for spatial memory maintenance |
| 糖原合酶激酶-3对于调节性T细胞的发育和功能至关重要。 |
Kandasamy, M. |
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Glycogen synthase kinase-3 is essential for Treg development and function |
| 保守的染色质调控因子控制秀丽隐杆线虫对胞内病原体的转录免疫反应 |
Tecle, E. |
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Conserved chromatin regulators control the transcriptional immune response to intracellular pathogens in Caenorhabditis elegans |
| 在分枝杆菌中破坏核黄素生物合成，确立了5-氨基-6-D-核糖氨基尿嘧啶（5-A-RU）作为MAIT细胞激动剂的关键前体。 |
Chengalroyen, M. D. |
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Disruption of riboflavin biosynthesis in mycobacteria establishes 5-amino-6-D-ribitylaminouracil (5-A-RU) as key precursor of MAIT cell agonists |
| 新型嵌套基因Aff3ir的破坏介导了小鼠中紊乱血流诱导的动脉粥样硬化 |
He, S. |
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Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in Mice |
| 拟南芥花分生组织中生长素信号传导中的随机基因表达 |
Kong, S. |
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Stochastic Gene Expression in Auxin Signaling in the Floral Meristem of Arabidopsis thaliana |
| 减少覆盖范围的空间异质性可以提高狗类狂犬病疫苗接种的有效性。 |
Ferguson, E. |
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Reducing spatial heterogeneity in coverage improves the effectiveness of dog vaccination against rabies |
| 元生物中g型溶菌酶的进化：对免疫和消化适应性的见解 |
Moroz, L. L. |
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Evolution of g-Type Lysozymes in Metazoa: Insights into Immunity and Digestive Adaptations |
| 基于系统发育的模拟表明，在真核生物起源期间，未采样的分支对基因流推断的影响较小。 |
Bernabeu, M. |
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Phylogeny-aware simulations suggest a low impact of unsampled lineages in the inference of gene flow during eukaryogenesis |
| 亚端粒特异性凝聚染色质受三种不同的组蛋白修饰调控 |
Osaki, M. |
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Subtelomere-specific condensed chromatin is regulated by three different histone modifications |
| 人群数据中极端离群RNA表达模式揭示了在个体子集中偶发性基因过度激活及其共调控模块 |
Xie, C. |
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Patterns of extreme outlier RNA expression in population data reveal sporadic over-activation of genes with co-regulated modules in subsets of individuals |
| 利用等位基因失衡数量性状位点模型探究顺式作用基因调控的极限 |
Seoighe, C. |
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Probing the limits of cis-acting gene regulation using a model of allelic imbalance quantitative trait loci |
| 三维机械限制指导肌肉干细胞的命运和功能 |
Park, G. |
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3D mechanical confinement directs muscle stem cell fate and function |
| 计算设计与评估用于可扩展邻近蛋白质组学的最佳诱饵集 |
Kasmaeifar, V. |
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Computational design and evaluation of optimal bait sets for scalable proximity proteomics |
| 可展开治疗性抗体的计算设计：高效遍历结合剂景观及逃逸突变的挽救 |
Dreyer, F. A. |
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Computational design of developable therapeutic antibodies: efficient traversal of binder landscapes and rescue of escape mutations |
| 更多细胞，高倍多重单细胞数据中的更多二聚体 |
Howitt, G. |
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More cells, more doublets in highly multiplexed single-cell data |
| 应激途径的镶嵌调控奠定了衰老细胞异质性的基础 |
Avelar, R. A. |
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Mosaic Regulation of Stress Pathways Underlies Senescent Cell Heterogeneity |
| 增强的弱监督千兆像素WSI训练池化技术提高了分类和病变定位效果 |
Chen, C.-C. |
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Enhanced Pooling for Weakly Supervised Gigapixel WSI Training Improves Classification and Lesion Localization |
| EGDiff：一种实验引导的扩散模型，用于蛋白质构象系综生成 |
Liu, Y. |
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EGDiff: An Experiment-Guided Diffusion model for protein conformational ensemble generation |
| 对福尔马林固定石蜡包埋（FFPE）组织进行单细胞RNA测序，在乳腺癌中鉴定出多纤毛细胞 |
Gonzalez-Martinez, S. |
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Single-cell RNA sequencing on formalin-fixed and paraffin-embedded (FFPE) tissue identified multi-ciliary cells in breast cancer |
| RUVBL1和RUVBL2是神经母细胞瘤中可药物干预的MYCN调节因子。 |
Siaw, J. T. |
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RUVBL1 and RUVBL2 are druggable MYCN regulators in neuroblastoma. |
| 源自患者的胶质母细胞瘤类器官作为实时模型，用于评估临床CAR-T细胞疗法的反应 |
Logun, M. |
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N/A |
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy |
| 真正的海洋昆虫——奥氏棘虱（Echinophthirius horridus von Olfers, 1816）（虱目：棘虱科）的独特体表形态 |
White, T. |
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N/A |
Unique cuticular morphology of a truly marine insect, Echinophthirius horridus von Olfers, 1816 (Phthiraptera: Echinophthiriidae) |
| 肌肉特异性Keap1缺失增强了肌肉力量生成，但并未能阻止小鼠因不活动导致的肌肉萎缩。 |
Miranda, E. R. |
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N/A |
Muscle-specific Keap1 deletion enhances force production but does not prevent inactivity-induced muscle atrophy in mice |
| 一项多组学普查揭示了与肥胖相关的微小RNA miR-let-7作为脂肪线粒体功能障碍和代际代谢衰退的新型引发因素。 |
Huang, C. |
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N/A |
A multi-omics census reveals obesity-associated microRNA miR-let-7 as novel instigator of adipose mitochondrial dysfunction and of intergenerational metabolic decline. |
| H+ 驱动超快根对根响应伤口 |
Ducla, J. |
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N/A |
H+ drives ultra-fast root-to-root responses to wounding |
| 通过MPK6磷酸化实现对MYC2的靶向降解揭示了JA信号传导的机制和意义 |
Han, K.-H. |
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N/A |
Targeted Degradation of MYC2 through MPK6 Phosphorylation Reveals Mechanisms and Implications for JA Signaling |
| 扩展的底物范围交叉手性连接法实现了长L-RNA的高效合成 |
Han, X. |
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N/A |
An Expanded Substrate Scope for Cross-Chiral Ligation Enables Efficient Synthesis of Long L-RNAs |
| 基于计算模型的细菌二硝基甲苯传感器设计 |
Bahiri Elitzur, S. |
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N/A |
Design of bacterial DNT sensors based on computational models |
| 噪声生物系统的数据驱动模型发现与模型选择 |
Wu, X. |
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N/A |
Data-driven model discovery and model selection for noisy biological systems |
| 自噬、泛素蛋白酶体系统和MAPK通路控制突触生长的温度依赖性。 |
De Leon, K. |
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N/A |
Autophagy, the Ubiquitin proteasome system, and the MAPK pathway control the temperature dependence of synaptic growth. |
| 在灵长类动物腹侧前运动皮层中时间感知期间的情境神经动力学 |
Diaz, H. |
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N/A |
Contextual Neural Dynamics During Time Perception in Primate Ventral Premotor Cortex |
| 使用合成轴突形态生成全脑连接组 |
Petkantchin, R. |
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N/A |
Generating brain-wide connectome using synthetic axonal morphologies |
| 猕猴扣带皮层中的冲突神经元 |
Corrigan, B. W. |
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N/A |
Conflict neurons in cingulate cortex of macaques |
| 阿尔茨海默病中与脑血管损伤和β-淀粉样蛋白并行的神经炎症通路 |
Rizvi, B. |
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N/A |
Parallel neuroinflammatory pathways to cerebrovascular injury and amyloid-beta in Alzheimer's disease |
| 多感官伽马刺激增强了成年神经发生，并在唐氏综合症小鼠模型中改善了认知功能。 |
Islam, M. R. |
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N/A |
Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in a mouse model of Down syndrome |
| 一项关于脊髓损伤即时后果的药理学调控的电生理学研究揭示了TRPV4拮抗作用的关键作用。 |
Mohammadshirazi, A. |
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N/A |
An electrophysiological study about the pharmacological manipulation of the immediate consequences of a spinal trauma reveals a crucial role for TRPV4 antagonism. |
| 秀丽隐杆线虫连接组中的双侧对称性与不对称性：基于冗余度测量的图论分析 |
Kim, P. S. |
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N/A |
Bilateral Symmetry and Asymmetry in the C. elegans Connectome: A Graph-Theoretic Analysis based on Redundancy Measures |
| 神经运动生成的背后空间和网络原理 |
Komi, S. |
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N/A |
Spatial and network principles behind neural generation of locomotion |
| 前视区谷氨酸能神经元对快速眼动睡眠起始和稳态的调控 |
Mondino, A. |
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N/A |
Regulation of REM Sleep Onset and Homeostasis by Preoptic Glutamatergic Neurons |
| 达成一致：fMRI-超扫描揭示了双人组在心理状态空间中探索以协调意见。 |
Speer, S. P. |
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N/A |
Finding Agreement: fMRI-hyperscanning reveals that dyads explore in mental state space to align opinions. |
| APOE通过抑制中性粒细胞胞外陷阱的产生，保护机体免受结核分枝杆菌严重感染。 |
Liu, D. |
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N/A |
APOE Protects Against Severe Infection with Mycobacterium tuberculosis by Restraining Production of Neutrophil Extracellular Traps |
| 肺部CD4+驻留记忆T细胞利用气道分泌细胞来刺激和调节中性粒细胞性过敏性气道疾病。 |
Ravi, V. R. |
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N/A |
Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate neutrophilic allergic airways disease. |
| 针对丙型肝炎病毒E1E2包膜糖蛋白的双特异性抗体 |
Radic, L. |
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N/A |
Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein |
| 普遍规律支配着质粒拷贝数 |
Ramiro-Martinez, P. |
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N/A |
Universal rules govern plasmid copy number |
| 加热处理改变了野生蓝莓土壤中细菌多样性和组成的时序动态。 |
Alaba, O. |
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N/A |
Warming treatments shift the temporal dynamics of diversity and composition of bacteria in wild blueberry soils. |
| 来自肠道细菌的D-乳酸通过驱动赖氨酸D-乳酸化来调节肝脏细胞的转录 |
Zang, Y. |
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N/A |
D-lactate derived from intestinal bacteria drives lysine D-lactylation to modulate transcription in liver cells |
| 聚合酶θ介导的末端连接的细胞周期调控是其对BLM-DNA2缺失敏感性的基础 |
McBrine, C. P. |
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N/A |
Cell cycle regulation of polymerase theta mediated end-joining underlies its sensitivity to loss of BLM-DNA2 |
| 顺式调控元件之间的协同作用可以使凝聚蛋白对于远端增强子功能变得可有可无。 |
Hansen, K. L. |
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N/A |
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function |
| 秀丽隐杆线虫中Sjögrens综合征核抗原1的同源物对于维持中心粒的结构完整性和双极有丝分裂纺锤体的组装是必需的。 |
Pfister, J. A. |
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N/A |
The C. elegans homolog of Sjögrens Syndrome Nuclear Antigen 1 is required for the structural integrity of the centriole and bipolar mitotic spindle assembly |
| VAPA介导利什曼原虫亚马逊种与宿主巨噬细胞之间的脂质交换。 |
Gdovinova, I. |
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N/A |
VAPA mediates lipid exchange between Leishmania amazonensis and host macrophages |
| EASI-ORC：一种用于酵母细胞器-RNA共定位测量中高效分析和分割smFISH图像的管道 |
Garin, S. |
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N/A |
EASI-ORC: A Pipeline for the Efficient Analysis and Segmentation of smFISH Images for Organelle-RNA Colocalization Measurements in Yeast |
| 解析单细胞中自主酶的变异性 |
Gnann, C. |
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N/A |
Dissecting autonomous enzyme variability in single cells |
| 一种体外有丝分裂后的鼠类作为肌肉损伤和修复的模型 |
Galluccio, A. |
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N/A |
A post-mitotic in vitro murine as a model of muscle damage and repair |
| A-C连接子控制着中心粒的粘附和复制。 |
Bournonville, L. |
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N/A |
The A-C Linker controls centriole cohesion and duplication |
| ATAD2通过HIRA/组蛋白H3.3依赖的机制驱动染色质动态变化。 |
Liakopoulou, A. |
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N/A |
ATAD2 drives HIRA/histone H3.3-dependent chromatin dynamics |
| 内皮细胞PROX1诱导中枢神经系统血脑屏障破坏 |
Gonzalez Hernandez, S. |
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N/A |
ENDOTHELIAL PROX1 INDUCES BLOOD-BRAIN BARRIER DISRUPTION IN THE CENTRAL NERVOUS SYSTEM |
| 斑马鱼的种质稳定性需要母源的Tdrd6a和Tdrd6c |
Consorte, A. |
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N/A |
Germplasm stability in zebrafish requires maternal Tdrd6a and Tdrd6c |
| 分析受保护与未受保护潮池的生物多样性 |
Chen, V. |
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N/A |
Analyzing Biodiversity in Protected vs. Unprotected Tide Pools |
| 通过将基因表达建模为二元性状，量化系统发育上的转录组周转 |
Thompson, A. |
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N/A |
Quantifying transcriptome turnover on phylogenies bymodeling gene expression as a binary trait |
| 二倍体有性生殖种群中的固定概率 |
Shi, Z. |
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N/A |
Fixation probability in a diploid sexually reproducing population |
| 瑞典牛品种的人口历史：估计与模型检验 |
Adepoju, D. |
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N/A |
Population history of Swedish cattle breeds: estimates and model checking |
| 雌性生殖系特异性蛋白Sakura与Otu相互作用，对生殖干细胞的更新和分化以及卵子发生至关重要。 |
Azlan, A. |
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N/A |
Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis |
| 基于k-mer的小麦集合全基因组关联分析揭示了白粉病抗性的新来源和多样性 |
Jaegle, B. |
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N/A |
k-mer-based GWAS in a wheat collection reveals novel and diverse sources of powdery mildew resistance |
| 一种基于基因型的方法识别了犬类中的腭裂和其他表型的变异 |
Buckley, R. M. |
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N/A |
A genotype-first approach identifies variants for orofacial clefts and other phenotypes in dogs |
| 定量蛋白质组质谱法分析蛋白激酶以确定人类激酶组的动态异质性 |
East, M. P. |
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N/A |
Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome |
| 尼帕病毒复制的结构基础 |
Sala, F. A. |
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N/A |
Structural basis of Nipah virus replication |
| 重复基因组区域中的长片段缺失签名记录了体细胞进化，并能够敏感地检测微卫星不稳定性。 |
Guo, Q. |
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N/A |
Long deletion signatures in repetitive genomic regions track somatic evolution and enable sensitive detection of microsatellite instability |
| 整合生物信息学与人工智能方法以识别影响蛋白质稳定性和功能的破坏性STAT1变异体 |
Kamal, E. |
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N/A |
Integrating Bioinformatics and Artificial Intelligence Methods to identify disruptive STAT1 variants impacting Protein Stability and Function |
| 基于深度学习的主要组织相容性复合体中的基序发现：入门指南 |
Alvarez, B. |
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N/A |
Deep Learning-Based Motif Discovery in MajorHistocompatibility Complex: A Primer |
| 一个基于浏览器的平台，用于在HPC环境中存储、可视化和分析大规模的3D图像。 |
Walker, L. A. |
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N/A |
A browser-based platform for storage, visualization, and analysis of large-scale 3D images in HPC environments |
| 基于优化后的蓝图进行ATP酶的从头设计，该蓝图适用于容纳P-loop基序 |
Kosugi, T. |
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N/A |
De novo design of ATPase based on the blueprint optimized for harboring the P-loop motif |
| 超越平面：鱼群在三维空间中采用梯形编队 |
Ko, H. |
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N/A |
Beyond planar: fish schools adopt ladder formations in 3D |
| 结构集合的弹性分析揭示了AAA+马达中手对手传递的能量基础 |
Mello, V. H. |
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N/A |
Elastic analysis of structural ensemble reveals the energetic basis of hand-over-hand in a AAA+ motor |
| 生物膜流丝的应力硬化行为 |
Savorana, G. |
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N/A |
Stress-hardening behaviour of biofilm streamers |
| 计算分析Nitazene衍生物在μ-阿片受体上的结合姿态 |
Clayton, J. |
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N/A |
Computational Analysis of the Binding Poses of Nitazene Derivatives at the mu-Opioid Receptor |
| 力学约束组织三维组织并协调肌肉分化 |
Nagle, I. |
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N/A |
Mechanical constraints organize 3D tissues and orchestrate muscle differentiation |
| APC协调GSK3对SETD8的磷酸化，以抑制结直肠癌 |
Cramer, Z. |
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N/A |
APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer |
| 时间多模态单细胞分析揭示了CAR-T细胞与胶质母细胞瘤的动态相互作用及对抗原阴性肿瘤细胞的靶向作用 |
Zhang, D. Y. |
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N/A |
Temporal multi-modal single-cell analyses reveal dynamic interactions of CAR-T cells with glioblastoma and targeting of antigen-negative neoplastic cells |
| STAT1与YAP1之间的正反馈环路刺激脂质生物合成，加速突变型KRAS结直肠癌细胞的生长，并促进化疗耐药性。 |
Wang, S. |
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N/A |
A feedforward loop between STAT1 and YAP1 stimulates lipid biosynthesis, accelerates tumor growth, and promotes chemotherapy resistance in mutant KRAS colorectal cancer. |
| 一种新的空间多组学方法，通过单个组织切片深入表征人类癌症组织 |
Adimi, Y. |
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N/A |
A new spatial multi-omics approach to deeply characterize human cancer tissue using a single tissue section |
| 降雨对田间条件下空气中小麦锈菌孢子昼夜周期性的破坏作用 |
Suffert, F. |
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N/A |
Disruptive effect of rainfalls on the diurnal periodicity of airborne wheat rust spore under field conditions |
| 系统遗传学解析阿尔茨海默病大脑基因表达网络 |
Zhao, P. |
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N/A |
Systems genetic dissection of Alzheimer's disease brain gene expression networks |
| 基于深度学习的图像分类揭示了病毒感染期间细胞死亡命运的异质性执行 |
Centofanti, E. |
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N/A |
Deep learning-based image classification reveals heterogeneous execution of cell death fates during viral infection |
| 建模上皮-间质转化（EMT）的动力学揭示了与泛癌中间状态和可塑性相关的基因 |
McDermott, M. |
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N/A |
Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity |
| 发现具有切换无限GPFA的时序组合神经流形 |
Yu, C. |
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N/A |
Discovering Temporally Compositional Neural Manifolds with Switching Infinite GPFA |
| Shank3B-/-小鼠中前额叶皮层（mPFC）PV中间神经元早期产后功能障碍 |
Peixoto, R. T. |
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N/A |
Early Postnatal Dysfunction of mPFC PV Interneurons in Shank3B-/- Mice |
| 神经甾体敏感的δ-GABAA受体对成年小鼠味觉岛叶皮层甜味偏好的调节作用 |
Yevoo, P. E. |
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N/A |
Modulation of sweet preference by neurosteroid-sensitive, δ-GABAA receptors in adult mouse gustatory insular cortex |
| JN.1加强疫苗对SARS-CoV-2变异株KP.3.1.1和XEC的中和作用影响 |
Arora, P. |
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N/A |
Impact of JN.1 booster vaccination on neutralisation of SARS-CoV-2 variants KP.3.1.1 and XEC |
| CMTM4是一种粘附调节因子，调控海胆胚胎中骨骼模式形成和初级间充质细胞迁移。 |
Descoteaux, A. E. |
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N/A |
CMTM4 is an adhesion modulator that regulates skeletal patterning and primary mesenchyme cell migration in sea urchin embryos |
| 土壤pH值影响感染个体宿主的噬菌体群落的组成 |
Lee, S. |
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N/A |
Soil pH influences the composition of bacteriophage communities infecting individual hosts |
| 一个统一的理论框架，用于解释不同尺度下围栏实验结果的矛盾，以评估蜱传疾病的风险 |
Freedman, A. S. |
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N/A |
A unifying theoretical framework for tick-borne disease risk to explain conflicting results of exclosure experiments across scales |
| 在感染野生禾本科植物的真菌物种中，种间杂交作为附加染色体起源的途径 |
Fagundes, W. C. |
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N/A |
Interspecies hybridization as a route of accessory chromosome origin in fungal species infecting wild grasses |
| 规模化衰老：来自狗衰老项目的年轻犬只和大型犬种显示出加速的表观遗传衰老。 |
McCoy, B. M. |
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N/A |
Aging at scale: Younger dogs and larger breeds from the Dog Aging Project show accelerated epigenetic aging. |
| 通过计算机分析和体外功效研究探索锦葵色素和芍药花色素作为潜在抗利什曼原虫药物的潜力 |
Goyzueta-Mamani, L. D. |
PDF |
N/A |
Exploring the Potential of Malvidin and Echiodinin as Probable Antileishmanial Agents Through In Silico Analysis And In Vitro Efficacy |
| 通过对比对抗开放集域适应实现单细胞数据整合与细胞类型注释 |
Aminzadeh, F. |
PDF |
N/A |
Single-Cell Data Integration and Cell Type Annotation through Contrastive Adversarial Open-set Domain Adaptation |
| 辉瑞-生物技术与莫德纳新冠疫苗中脂质纳米颗粒的比较分析：来自分子动力学模拟的洞察 |
Biswal, M. R. |
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N/A |
Comparative Analysis of Lipid Nanoparticles in Pfizer-BioNTech and Moderna COVID-19 Vaccines: Insights from Molecular Dynamics Simulations |
| 在限制压力下三维菌落中应激响应细菌的生长 |
Rahbar, S. |
PDF |
N/A |
Growth of Stress-Responsive Bacteria in 3D Colonies under Confining Pressure |
| SATB2和circ3915 RNA的染色质失调驱动了类似KRAS的致癌转化 |
Eleazer, R. |
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N/A |
SATB2 and circ3915 RNA chromatin dysregulation drive KRAS-like oncogenic transformation |
| 来自白垩纪缅甸琥珀的一个显著的缨翅目家族，Miralidae stat. nov.（= Dinglidae syn. nov.；半翅目：胸喙亚目） |
Ivanov, G. |
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N/A |
A remarkable psyllomorph family from Cretaceous Burmese amber, Miralidae stat. nov. (= Dinglidae syn. nov.; Hemiptera: Sternorrhyncha) |
| 扰动诱发皮层活动的重测信度反映了反应性平衡控制中稳定的个体差异 |
Mirdamadi, J. L. |
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N/A |
Test-retest reliability of perturbation-evoked cortical activity reflects stable individual differences in reactive balance control |
| SPLASH-structure：一种从原始测序数据中识别RNA二级结构的统计方法，无需进行多序列比对 |
Wang, J. F. |
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N/A |
SPLASH-structure: a statistical approach to identify RNA secondary structures from raw sequencing data, bypassing multiple sequence alignment |
| Latexin通过促进平滑肌细胞增殖和巨噬细胞迁移来促进新生内膜的形成。 |
Kazama, K. |
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N/A |
Latexin facilitates neointimal formation via promoting smooth muscle cell proliferation and macrophage migration |