| 关于已知最早生命形式的本质 |
Kanaparthi, D. |
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N/A |
On the nature of the earliest known life forms |
| 肠道细菌衍生的鞘脂类物质改变了对口服霍乱疫苗抗原的先天免疫反应 |
Chac, D. |
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N/A |
Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens |
| 可扩展的基于图像的空间转录组数据集可视化与对齐 |
Preibisch, S. |
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N/A |
Scalable image-based visualization and alignment of spatial transcriptomics datasets |
| PERK激酶活性受铜结合调控——调节内质网应激耐受的新型调控范式 |
Newton, S. E. B. |
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N/A |
PERK Kinase Activity is Regulated by Copper Binding-A New Regulatory Paradigm for Modulation of ER Stress Tolerance |
| 核苷酸变压器：构建和评估人类基因组学的稳健基础模型 |
Dalla-Torre, H. |
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N/A |
The Nucleotide Transformer: Building and Evaluating Robust Foundation Models for Human Genomics |
| 单荧光团成像揭示了生物分子凝聚体的不同环境和结构特征 |
Wu, T. |
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N/A |
Single fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates |
| 双重MAPK抑制触发促炎信号并增强BRAF V600E胶质瘤对T细胞介导的检查点疗法的敏感性 |
Xing, Y. L. |
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N/A |
Dual MAPK Inhibition Triggers Pro-inflammatory Signals and Sensitizes BRAF V600E Glioma to T Cell-Mediated Checkpoint Therapy |
| 稳态突触缩放与稳态结构可塑性之间的相互作用维持了神经网络的稳健放电率。 |
Lu, H. |
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N/A |
The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks |
| 通过从整体到单细胞的解卷积方法，描绘白血病干细胞的药物敏感性 |
Alexandre, C. |
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N/A |
Profiling drug sensitivity of leukemic stem cells via bulk-to-single-cell deconvolution |
| 在工作记忆中，视觉层次结构逐渐向类别表征过渡，但在感知过程中并非如此。 |
Chunharas, C. |
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N/A |
A gradual transition toward categorical representations along the visual hierarchy during working memory, but not perception. |
| 一种新型泛RAS抑制剂，其独特的作用机制可阻断小鼠模型中胃肠癌的生长 |
Foote, J. |
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A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer |
| 使用传递熵测量评估RAS-MAPK系统中的信息流 |
Umeki, N. |
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N/A |
Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements |
| 稳定性指标在不同数据质量下表现稳健，但对社区规模较为敏感。 |
O'Brien, D. A. |
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N/A |
Stability metrics are robust across data qualities but sensitive to community size. |
| RpoS激活了沙门氏菌Typhi生物膜的形成，并驱动其在胆囊中的持久性。 |
Desai, S. |
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N/A |
RpoS activates formation of Salmonella Typhi biofilms and drives persistence in the gall bladder |
| 进化相关性对物种多样化和树形的影响 |
Qin, T. |
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N/A |
Impact of Evolutionary Relatedness on Species Diversification and Tree Shape |
| 古多肽中的电子自旋极化与电荷动力学：它们在蛋白质功能中的作用 |
Vyas, P. |
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N/A |
Electron Spin-Polarizability and Charge Dynamics in Ancient Polypeptides : Their Role in Protein Function |
| 皮质连接组的高阶结构中的特定抑制和去抑制 |
Reimann, M. W. |
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N/A |
Specific inhibition and disinhibition in the higher-order structure of a cortical connectome |
| 使用因果启发的神经网络进行治疗扰动的组合预测 |
Gonzalez, G. |
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N/A |
Combinatorial prediction of therapeutic perturbations using causally-inspired neural networks |
| 通过从相同原始读取数据中提取的保守核基因序列和整个叶绿体基因组，对亚科进化进行了综合研究。 |
Witharana, E. P. |
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N/A |
Comprehensive study of subfamily evolution through sequences of conserved nuclear genes and whole chloroplast genomes extracted from the same raw read data |
| 过量磷酸盐对沿海浮游生物群落的影响：波罗的海中尺度实验 |
Spilling, K. |
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Effects of excess phosphate on a coastal plankton community: a mesocosm experiment in the Baltic Sea |
| 一种结核分枝杆菌分泌的毒力因子破坏宿主snRNP生物发生 |
Chauhan, K. |
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A Mycobacterium tuberculosis secreted virulence factor disrupts host snRNP biogenesis |
| 探索在不同热带森林、树木组织和发育阶段中的茜草科真菌内生菌 |
Castillo-Gonzalez, H. |
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N/A |
Exploring Rubiaceae fungal endophytes across contrasting tropical forests, tree tissues, and developmental stages |
| 在寄生蜂Lysiphlebus fabarum中，兼性性别是否是两全其美的选择？ |
Boulton, R. A. |
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Is facultative sex is the best of both worlds in the parasitoid wasp Lysiphlebus fabarum? |
| 动态强化学习揭示了奖励学习过程中策略随时间变化的转变。 |
Venditto, S. J. C. |
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N/A |
Dynamic reinforcement learning reveals time-dependent shifts in strategy during reward learning. |
| 范德华力、静电作用和氢键在纤维素Iβ和II晶体相对稳定性中的作用 |
Kullmann, R. |
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N/A |
Role of van der Waals, electrostatic, and hydrogen-bond interactions for the relative stability of cellulose Iβ and II crystals |
| 人CTF18夹钳加载器与PCNA结合的结构 |
Briola, G. |
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Structure of the human CTF18 clamp loader bound to PCNA |
| 使用Sentence-BERT从预测数据库中提炼疾病中的蛋白质水平微RNA靶标相互作用 |
Chen, B. |
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N/A |
Refining Protein-Level MicroRNA Target Interactions in Disease from Prediction Databases Using Sentence-BERT |
| GTP环水解酶II（gch2）与球蟒中的色觉缺失：基于蝶呤色素沉着的新脊椎动物模型 |
Garcia-Elfring, A. |
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N/A |
GTP cyclohydrolase II (gch2) and axanthism in ball pythons: a new vertebrate model for pterin-based pigmentation |
| 激活血红素代谢促进关节内损伤或手术暴露后的组织健康 |
Liman, S. |
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N/A |
Activation of Heme Metabolism Promotes Tissue Health after Intraarticular Injury or Surgical Exposure |
| NMDARs和协同激动剂的位置控制着黑质多巴胺神经元中爆发的产生 |
Ringlet, S. |
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N/A |
Location of NMDARs and co-agonist controls the generation of bursts in nigral dopamine neurons |
| II型糖尿病中骨骼肌肌球蛋白超松弛与能量代谢失调 |
Lewis, C. T. |
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N/A |
Dysregulated Skeletal Muscle Myosin Super-relaxation and Energetics in Type II Diabetes |
| HIV共受体相关基因（CCR5和CXCR4）启动子甲基化：原创研究 |
Esman, A. |
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N/A |
HIV Coreceptors Related Genes (CCR5 and CXCR4) Promoter Methylation: Original Research |
| MatP在细菌细胞分裂周期时空调控中的生物分子凝聚体的证据 |
Barros-Medina, I. |
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N/A |
Evidence for biomolecular condensates of MatP in spatiotemporal regulation of the bacterial cell division cycle |
| MLCK/MLCP通过重新分布生长锥的F-肌动蛋白来调节哺乳动物轴突的再生 |
Saijilafu, |
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N/A |
MLCK/MLCP regulates mammalian axon regeneration via the redistribution of the growth cone F-actin |
| 大肠杆菌细胞中DnaA和DNA的相对分布作为其表型变异的因素 |
Namboodiri, S. K. |
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Relative Distribution of DnaA and DNA in Escherichia coli Cells as a Factor of Their Phenotypic Variability |
| 克服冷冻电镜图各向异性揭示了具有不同化学计量比的ALK-细胞因子复合物 |
Felix, J. |
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N/A |
Overcoming cryo-EM map anisotropy reveals ALK-cytokine assemblies with distinct stoichiometries |
| 外毛细胞搅动耳蜗内的液体 |
Lee, C. |
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N/A |
Outer hair cells stir cochlear fluids |
| 多巴胺与时间折扣：重新审视药理学与个体差异 |
Smith, E. |
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N/A |
Dopamine and temporal discounting: revisiting pharmacology and individual differences |
| IL-6和IL-27负向调控与淋巴驱动性滑膜炎相关的CRTAM表达CD4+ T细胞。 |
Derrac Soria, A. |
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N/A |
IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis. |
| 分布式学习推动了统计抑制和聋化 |
Luthra, S. |
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N/A |
Distributional learning drives statistical suppression and deafening |
| 一种受生理启发的混合CPG/反射控制器，用于自行车模拟，并可推广到步行 |
Severini, G. |
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N/A |
A physiologically inspired hybrid CPG/Reflex controller for cycling simulations that generalizes to walking |
| 一个小的信号域控制着磷酸肌醇磷酸酶5激酶（PPIP5K）在磷酸盐稳态中的磷酸酶活性。 |
Raia, P. |
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N/A |
A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis. |
| 一种基于纳米抗体的方法，用于在活细胞中捕获和可视化二元蛋白质复合物的特定相互作用 |
Sleiman, N. H. |
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N/A |
A nanobody-based approach to capture and visualize specific interactions of binary protein complexes in living cells |
| 利用MELISSA模型对整合位点数据进行安全评估 |
Lin, T.-Y. |
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N/A |
Modeling integration site data for safety assessment with MELISSA |
| 全球土壤传播蠕虫的多样性揭示了影响诊断目标的群体偏向性遗传变异 |
Papaiakovou, M. |
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N/A |
Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets |
| 一个支持法国淡水环境中水生大型无脊椎动物DNA条形码分析的注释参考库 |
Gauvin, P. |
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N/A |
An annotated reference library for supporting DNA metabarcoding analysis of aquatic macroinvertebrates in French freshwater environments |
| 斑马鱼Pol-Theta与人Pol-Theta，具有同源功能的直系同源物 |
Thomas, C. |
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N/A |
Zebrafish Pol-Theta and Human Pol-Theta, Orthologues with Homologous Function |
| 微流控技术调控显微切割肿瘤中的微血管 |
Nguyen, T. N. H. |
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N/A |
Microfluidic Modulation of Microvasculature in Microdissected Tumors |
| H3K9甲基化非依赖性活性在异染色质焦点、基因抑制和器官发生中的HPL-2/HP1作用 |
Delaney, C. E. |
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N/A |
H3K9 methylation-independent activity for HPL-2/HP1 in heterochromatin foci, gene repression, and organogenesis |
| IgBlend：在抗体语言模型中统一三维结构和序列 |
Malherbe, C. |
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N/A |
IgBlend: Unifying 3D Structures and Sequences in Antibody Language Models |
| 茄科生物合成基因簇的亚功能化与表观遗传调控 |
Priego-Cubero, S. |
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N/A |
Sub-functionalization and epigenetic regulation of a biosynthetic gene cluster in Solanaceae |
| 具有改变的RNA结合和降解活性的病理性PNPase变体影响细菌和人类细胞模型的表型 |
Pizzoccheri, R. |
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N/A |
Pathological PNPase variants with altered RNA binding and degradation activity affect the phenotype of bacterial and human cell models |
| 普遍规则支配着质粒拷贝数 |
Ramiro-Martinez, P. |
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N/A |
Universal rules govern plasmid copy number |
| 一种以基因型为先导的方法在狗中识别出与口腔面部裂和其他表型相关的变异 |
Buckley, R. M. |
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N/A |
A genotype-first approach identifies variants for orofacial clefts and other phenotypes in dogs |
| 利用多组儿科临床睡眠数据洞察神经发育：儿科睡眠回顾性分析（RASP）队列研究 |
Gong, N. N. |
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N/A |
Leveraging clinical sleep data across multiple pediatric cohorts for insights into neurodevelopment: the Retrospective Analysis of Sleep in Pediatric (RASP) cohorts study |
| 早期听觉和成年求偶经历与歌者身份相互作用，塑造雌性斑胸草雀对歌声的神经反应 |
Catalano, I. |
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N/A |
Early auditory and adult mating experiences interact with singer identity to shape neural responses to song in female zebra finches |
| 悬浮组织开放式微流控图案化技术（STOMP） |
Haack, A. J. |
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N/A |
Suspended Tissue Open Microfluidic Patterning (STOMP) |
| TSST-1通过激活CD8+T细胞促进金黄色葡萄球菌在阴道内的定植 |
Dufresne, K. |
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N/A |
TSST-1 promotes colonization of Staphylococcus aureus within the vaginal tract by activation of CD8+T cells |
| 青少年在晶体智力和流体智力方面的神经相关性存在差异 |
Qiu, B. |
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N/A |
Neural correlates differ between crystallized and fluid intelligence in adolescents |
| 顶枕叶伽马经颅交流电刺激对视觉空间注意任务中行为表现和神经活动的影响 |
Zheng, T. |
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N/A |
After-effects of Parieto-occipital Gamma Transcranial Alternating Current Stimulation on Behavioral Performance and Neural Activity in Visuo-spatial Attention Task |
| 亨廷顿病小鼠模型中运动学习和皮层纹状体网络活动的早期改变 |
Badreddine, N. |
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N/A |
Early alterations of motor learning and corticostriatal network activity in a Huntington's disease mouse model |
| 阿尔茨海默病相关基因型对老年小鼠慢性诱发性癫痫结果和抗癫痫药物活性的影响存在差异 |
Knox, K. |
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N/A |
Alzheimer's disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine activity in aged mice |
| 驼背时间转录因子决定了果蝇NB5-2谱系中间神经元的分子身份、形态和突触前靶向。 |
Pollington, H. Q. |
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N/A |
The Hunchback temporal transcription factor determines interneuron molecular identity, morphology, and presynapse targeting in the Drosophila NB5-2 lineage |
| 动物声学交流保持着一种普遍的最优节奏 |
Piette, T. |
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N/A |
Animal acoustic communication maintains a universal optimum rhythm |
| 雌性大鼠性行为的时间交配模式 |
Oyem, J. C. |
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N/A |
The temporal copulatory patterns of female rat sexual behavior |
| 钾通道模拟中的电荷缩放：电导、离子占据、电压响应与选择性 |
Hui, C. |
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N/A |
Charge Scaling in Potassium Channel Simulations: Conductance, Ion Occupancy, Voltage Response, and Selectivity |
| 基于化学交换饱和转移的蛋白质次要构象状态精确推断的NMR实验条件自主自适应优化 |
Kasai, T. |
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N/A |
Autonomous adaptive optimization of NMR experimental conditions for precise inference of minor conformational states of proteins based on chemical exchange saturation transfer |
| 组蛋白H3作为核小体核心颗粒中的氧化还原开关：来自分子建模的见解 |
Karami, Y. |
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N/A |
Histone H3 as a redox switch in the nucleosome core particle: insights from molecular modeling |
| 在右美托咪定诱导意识丧失期间大脑连接性和神经血管动力学的变化 |
Fotiadis, P. |
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N/A |
Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness |
| 大脑“暗能量”之谜升级：FDG摄取、递送和磷酸化，及其与静息态脑活动的耦合 |
Volpi, T. |
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N/A |
The brain's "dark energy" puzzle upgraded: FDG uptake, delivery and phosphorylation, and their coupling with resting-state brain activity |
| 复杂的慢波在5-MeO-DMT作用下彻底重塑了人类大脑的动态。 |
Blackburne, G. |
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N/A |
Complex slow waves radically reorganise human brain dynamics under 5-MeO-DMT |
| 与二值化的病灶图像相比，连续的病灶图像能更准确地预测中风后的结果。 |
Hope, T. M. H. |
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N/A |
Continuous lesion images drive more accurate predictions of outcomes after stroke than binary lesion images |
| 大鼠脊髓损伤中基于间充质干细胞衍生的细胞外囊泡疗法的局部细胞因子变化 |
Kabdesh, I. |
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N/A |
Local cytokine changes in response to mesenchymal stem cell-derived extracellular vesicles-based therapy in rat spinal cord injury |
| 调和感觉衰减与增强：自我生成的感觉反馈的时间动态 |
Suzuishi, Y. |
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N/A |
Reconcile sensory attenuation and enhancement: The temporal dynamics of self-generated sensory feedback |
| 神经肽依赖的尖峰时间精确性和昼夜节律输出神经元的可塑性 |
Chong, B. |
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N/A |
Neuropeptide-dependent spike time precision and plasticity in circadian output neurons |
| 在观察动作时，空间信息和解剖结构信息的处理具有不同的时间尺度 |
Baptiste, W. M. |
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N/A |
Separate timescales for spatial and anatomical information processing during action observation |
| 成年大鼠中的多重情境辨别：性别差异及厌恶记忆的时间依赖性泛化动态 |
Alves, F. N. L. |
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N/A |
Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory |
| 研究非人类灵长类动物三叉神经元机械激活电流 |
Lindquist, K. |
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N/A |
Investigating Mechanically Activated Currents from Trigeminal Neurons of Non-Human Primates |
| 小鼠嗅觉感觉神经元轴突内源性再生的区域性缺陷 |
Kunkhyen, T. |
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N/A |
Regional deficits in endogenous regeneration of mouse olfactory sensory neuron axons |
| 突触前丝状伪足形成动突触，并调节膜力学以促进同步神经传递和癫痫发作。 |
Jain, A. |
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N/A |
Presynaptic filopodia form kinapses and modulate membrane mechanics for synchronous neurotransmission and seizure generation. |
| 视觉皮层中附近刺激之间的抑制性相互作用反映了拥挤现象。 |
Soo, L. |
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N/A |
Suppressive interactions between nearby stimuli in visual cortex reflect crowding |
| 氯胺酮通过小鼠中Ca2+通透性AMPA受体的表达逆转慢性应激引起的行为变化 |
Flowers, J. C. |
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N/A |
Ketamine reverses chronic stress-induced behavioral changes via the expression of Ca2+-permeable AMPA receptors in mice |
| 驱动蛋白自抑制需要肘部磷酸化 |
Chen, G. |
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N/A |
Kinesin Autoinhibition Requires Elbow Phosphorylation |
| 通过机器学习模型进行可扩展且可解释的疾病预测的高维生物标志物识别 |
Dai, Y. |
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N/A |
High-dimensional Biomarker Identification for Scalable and Interpretable Disease Prediction via Machine Learning Models |
| 通过可解释机器学习洞察心力衰竭代谢标志物 |
Baron, C. |
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N/A |
Insights into Heart Failure Metabolite Markersthrough Explainable Machine Learning |
| 斑马鱼模型预测乳腺癌患者化疗反应：迈向个性化医疗的共临床研究 |
Mendes, R. V. |
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N/A |
Zebrafish Avatar-test predicts patient's tumor response to chemotherapy in breast cancer: a co-clinical study towards personalized medicine |
| 绘制乳腺癌在肺和肝转移的生态位 |
Sznurkowska, M. K. |
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N/A |
Mapping the niche of breast cancer metastases in lung and liver |
| 不同综合施肥水平对埃塞俄比亚南部瓦切莫大学大蒜（Allium sativum L.）产量和品质的影响 |
Shumbulo, A. |
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N/A |
Garlic (Allium sativum L.) yield and quality as affected by different integrated fertilizer levels at Wachemo university, southern Ethiopia |
| 树木高度与膨压限制：叶表皮细胞解剖学无证据支持 |
Aleman-Sancheschulz, G. |
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N/A |
Turgor limitation of tree height: no evidence from leaf epidermal cell anatomy |
| 阿片类药物使用者对奖励的前中部扣带回反应迟钝，通过前额叶经颅磁刺激可恢复正常 |
Biernacki, K. |
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N/A |
Blunted anterior midcingulate response to reward in opioid users is normalized by prefrontal transcranial magnetic stimulation |
| 对比功能连接定义了重度抑郁症中神经生理学指导的症状维度 |
Zhu, H. |
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N/A |
Contrastive functional connectivity defines neurophysiology-informed symptom dimensions in major depression |
| 在离线期间的海马体涟漪能够预测人类的运动序列学习 |
Chen, P.-C. |
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N/A |
Hippocampal ripples during offline periods predict human motor sequence learning |
| 探索Instagram在新一代中的教育潜力：一项关于“领养细菌”影响的研究 |
Rodrigues Cintra Armellini, B. |
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N/A |
Exploring the Educational Potential of Instagram in the New Generations: A Study on the Impact of "Adopt a Bacterium" |
| 冰川消退对生态系统发育及碳动态的影响 |
Ceresa, E. |
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N/A |
Glacier Retreat Effects On Ecosystem Development And Carbon Dynamics |
| 揭示“被遗忘的民族”的起源与基因构成：一项关于喀尔巴阡盆地萨尔马提亚时期人口的研究 |
Schütz, O. |
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Unveiling the Origins and Genetic Makeup of the 'Forgotten People': A Study of the Sarmatian-Period Population in the Carpathian Basin |
| 近东血统进入意大利中部的时间早于罗马帝国的建立。 |
Ravasini, F. |
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The arrival of the Near Eastern ancestry in Central Italy predates the onset of the Roman Empire |
| 利用神经不应期去除电刺激伪影的方法：通过对比阴极和阳极刺激进行验证 |
Nakhmani, A. |
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A Method for Electrical Stimulus Artifact Removal Exploiting Neural Refractoriness: Validation by Contrasting Cathodic and Anodic Stimulation |
| Nutri Complex 150+：一种新的面部年轻化有效方法 |
Privitera, A. |
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Nutri Complex 150+: a new and effective approach to facial rejuvenation |
| HIV-1出芽需要氧化还原酶MICAL1介导的皮质肌动蛋白解聚 |
Serrano, T. |
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HIV-1 budding requires cortical actin disassembly by the oxidoreductase MICAL1 |
| ASCL1介导的染色质结合和基因激活的独特增殖和神经元程序具有细胞周期阶段特异性 |
Beckman, W. F. |
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Distinct proliferative and neuronal programmes of chromatin binding and gene activation by ASCL1 are cell cycle stage-specific |
| 由磷脂1,2-二油酰基-sn-甘油-3-磷酸乙醇胺组成的脂质纳米颗粒封装的Spike mRNA疫苗在仓鼠中诱导了强大的B细胞和T细胞反应，这些反应与对COVID-19的保护相关。 |
Quadiri, A. |
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Spike mRNA Vaccine Encapsulated in a Lipid Nanoparticle Composed of Phospholipid 1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine Induced Potent B- and T-cell Responses Associated with Protection against COVID-19 in Hamsters |
| FungAMR：真菌中抗菌药物耐药性突变的综合概述 |
Bedard, C. |
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FungAMR: A comprehensive portrait of antimicrobial resistance mutations in fungi |
| 土壤水分对农业土壤微生物多样性及其酶活性的影响 |
Bogati, K. |
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Impact of soil moisture on microbial diversity and their enzyme activity on agricultural soil |
| 建立了一种慢性铜绿假单胞菌小鼠肺部感染模型，模拟了人类囊性纤维化的病理生理学和炎症反应。 |
Vaillancourt, M. |
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A chronic Pseudomonas aeruginosa mouse lung infection modeling the pathophysiology and inflammation of human cystic fibrosis |
| 基因组间隔识别码（GenomicGapID）：利用保守基因组位点的空间分布进行广谱微生物鉴定 |
Asthana, V. |
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GenomicGapID: Leveraging Spatial Distribution of Conserved Genomic Sites for Broad-Spectrum Microbial Identification |
| 慢性感染可能导致类似SARS-CoV-2的病毒进化爆发，而没有上位效应。 |
Rodriguez-Horta, E. |
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Chronic infections can generate SARS-CoV-2-like bursts of viral evolution without epistasis |
| FAN1缺陷促进亨廷顿病的结构和分子基础 |
Pluciennik, A. |
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Structural and molecular basis of FAN1 defects in promoting Huntington's disease |
| 人类外泌体的结构延伸通过最小界面实现 |
Xu, H. D. |
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Structural extension of the human exocyst is enabled by a minimal interface |
| 用于杆状病毒系统和酵母的多基因载体模块化克隆 |
Lai, Z. |
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Modular cloning of multigene vectors for the baculovirus system and yeast |
| 基于细胞的高内涵方法用于SARS-CoV-2中和，识别出独特的单克隆抗体和PI3K通路抑制剂。 |
Cabel, C. R. |
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Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors. |
| 基于机器学习的3' UTR设计以提高mRNA稳定性 |
Morrow, A. K. |
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ML-driven design of 3' UTRs for mRNA stability |
| 分子状态在胡须皮质神经元细胞类型发育和可塑性中的基础 |
Butrus, S. |
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Molecular states underlying neuronal cell type development and plasticity in the whisker cortex |
| 恶性疟原虫Vps16同源物的特征，Vps-2 C连接复合体成员之一。 |
Galaup, T. |
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Characterization of the Plasmodium falciparum homologue of Vps16, a member of the Vps-2 C tethering complex. |
| 细菌鞭毛马达速度对质子动力势的非线性依赖性及其对游泳的影响 |
Krasnopeeva, E. |
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Nonlinear dependency of the bacterial flagellar motor speed on proton motive force and its consequences for swimming |
| 解码HIV诱导的CPSF6点状结构及其与核斑点的融合过程 |
Tomasini, C. D. |
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Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle |
| TGF-beta介导的JunB-HBZ核转位是HTLV-1诱导白血病的关键驱动因素 |
Yasunaga, J. |
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JunB-HBZ nuclear translocation by TGF-beta is a key driver in HTLV-1-mediated leukemogenesis |
| 人类尿液中尿路致病细菌的代谢组学调查 |
Chan, C. C. |
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Metabolomics survey of uropathogenic bacteria in human urine |
| 扩展中的松露环境：对旧和新块菌属大块菌栖息地中微生物动态的研究 |
Rondolini, M. |
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The expanding truffle environment: a study of the microbial dynamics in old and new Tuber magnatum Picco habitat |
| 洋葱叶和鳞茎组织中伯克霍尔德菌（Burkholderia gladioli）的独特致病机制 |
Paudel, S. |
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Distinct Virulence Mechanisms of Burkholderia gladioli in Onion Foliar and Bulb Scale Tissues |
| 种族和民族对口腔微生物群的多样性和特征的影响 |
Wang, Q. |
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Diversity and characteristics of the oral microbiome influenced by race and ethnicity |
| 转基因水稻品系中甲烷排放量的减少与根际微生物氢循环的改变有关 |
Shi, L.-D. |
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Reduced methane emissions in transgenic rice genotypes are associated with altered rhizosphere microbial hydrogen cycling |
| DNA修复基因uvrA发生临床突变，使结核分枝杆菌在宿主体内获得生存优势。 |
Saba Naz, |
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A clinical mutation in uvrA, a DNA repair gene, confers survival advantage to Mycobacterium tuberculosis in the host |
| Primosomal蛋白PriC通过绕过DnaA-DnaB相互作用步骤，在oriC处加载DnaB解旋酶，从而缓解复制起始压力。 |
Yoshida, R. |
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Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC |
| 突变剂对硝基呋喃妥因耐药性发展的进化风险分析 |
Kettlewell, R. |
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Evolutionary risk analysis of mutators for the development of nitrofurantoin resistance |
| 巨型病毒创造亚细胞环境以克服密码子-tRNA不匹配 |
Zhang, R. |
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Giant virus creates subcellular environment to overcome codon-tRNA mismatch |
| 用于量化病毒准种遗传多样性的相似性加权熵 |
Wu, J. |
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Similarity-weighted entropy for quantifying genetic diversity in viral quasispecies |
| 患者对达托霉素耐药性的获得导致果蝇的毒力降低 |
Lamy, B. |
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Acquisition of daptomycin resistance in patients results in decreased virulence in Drosophila |
| 纤毛虫藻类Heterosigma akashiwo的病毒感染不仅影响了细胞内有机物的组成，还改变了沿海原核生物群落的动态。 |
Takebe, H. |
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Viral infection to the raphidophycean alga Heterosigma akashiwo affects both intracellular organic matter composition and dynamics of a coastal prokaryotic community |
| R5噬菌体在高风险铜绿假单胞菌分离株优势中的作用 |
Zhang, L. |
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Role of R5 Pyocin in the Predominance of High-Risk Pseudomonas aeruginosa Isolates |
| 沙门氏菌利用宿主和细菌来源的β-丙氨酸在宿主巨噬细胞内进行复制 |
Ma, S. |
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Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages |
| DNA拓扑异构酶I在E. coli中作为转录延伸的超螺旋传感器 |
Vidmar, V. |
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DNA topoisomerase I acts as supercoiling sensor for transcription elongation in E. coli |
| 线粒体DNA释放与cGAS-STING通路的激活在致死性Stx12敲除小鼠中的作用 |
Kang, J.-S. |
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Mitochondrial DNA Release and Activation of the cGAS-STING Pathway in Lethal Stx12 Knockout Mice |
| 影响埃及伊蚊和白纹伊蚊（双翅目：蚊科）的环境和人为因素，重点在于自然感染和传播：对哥伦比亚新兴媒介的启示。 |
Mantilla, J. S. |
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Environmental and anthropic factors influencing Aedes aegypti and Aedes albopictus (Diptera: Culicidae), with emphasis on natural infection and dissemination: Implications for an emerging vector in Colombia. |
| 野生、自由生活的家鼠社会群体中的发声交流具有季节性。 |
Jourjine, N. |
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Vocal communication is seasonal in social groups of wild, free-living house mice |
| 利用局部超荷电病毒衣壳进行阴离子环二核苷酸STING激动剂的细胞质递送 |
Huang, P. |
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Cytosolic delivery of anionic cyclic dinucleotide STING agonists with locally supercharged viral capsids |
| 计算设计一种用于全细胞生物转化的热稳定从头生物催化剂 |
Elaily, W. |
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Computational design of a thermostable de novo biocatalyst for whole cell biotransformations |
| TAOK2 在16p11.2缺失和重复携带者中驱动相反的纤毛长度缺陷 |
Ferreccio, A. |
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TAOK2 Drives Opposing Cilia Length Deficits in 16p11.2 Deletion and Duplication Carriers |
| 局部皮质抑制性子网络的形态受到锥体神经元前体类型的影响。 |
Gothard, G. |
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Local cortical inhibitory subnetworks are shaped by pyramidal neuron progenitor type |
| 言语产生中从计划到执行的神经机制 |
Duraivel, K. |
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Neural mechanisms of the transition from planning to execution in speech production |
| 多重需求网络中信息编码与交换的时空特性分析 |
Karimi-Rouzbahani, H. |
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Spatiotemporal characterisation of information coding and exchange in the multiple demand network |
| 奖励和惩罚的偶然性转变揭示了腹侧被盖区多巴胺神经元和GABA神经元在行为灵活性中的不同作用 |
Lefner, M. J. |
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Reward and punishment contingency shifting reveals distinct roles for VTA dopamine and GABA neurons in behavioral flexibility |
| APOE4影响皮层神经发育并改变人脑类器官中的网络形成 |
Meyer-Acosta, K. K. |
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APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids |
| 纹状体细胞类型特异性分子特征揭示了肌张力障碍模型中的治疗靶点 |
Roman, K. M. |
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Striatal cell-type-specific molecular signatures reveal therapeutic targets in a model of dystonia |
| 感觉皮层中神经元的电学多样性 |
Calcini, N. |
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N/A |
Electrical diversity of neurons in sensory cortices |
| 开发具有广泛治疗潜力的临床可行非肌肉肌球蛋白II小分子抑制剂 |
Radnai, L. |
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Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential |
| 香烟烟雾会损害酿酒酵母的胞吞过程。 |
shukla, A. |
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N/A |
Cigarette smoke impairs the endocytotic process in Saccharomyces cerevisiae |
| 时空控制多层同轴流在带有级联喷嘴的3D打印微通道中 |
Werner, H. |
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Spatiotemporal control of a multilayered co-axial flow in a 3D printed microchannel with cascaded nozzles |
| TPLATE复合体的结构支架在植物胞吞过程中使膜发生变形。 |
Kraus, J. M. |
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The structural scaffold of the TPLATE complex deforms the membrane during plant endocytosis |
| 催产素Gαi信号诱导的杏仁核星形胶质细胞过程回缩塑造行为应激反应 |
Baudon, A. |
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Oxytocin Gαi signaling-induced amygdala astrocytes processes retraction shapes behavioral stress response |
| 揭示人结肠上皮类器官中细胞分裂与细胞外基质之间的机械相互作用：基于数字体积相关技术的四维研究 |
Magne, L. |
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Unveiling mechanical interactions between cell division and extracellular matrix in human colonic epithelium organoids: A 4D study using DVC |
| 有丝分裂后依赖PP2A-Ankle2的核重组机制 |
Li, J. |
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Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis |
| LRRK2突变的微胶质细胞在受到神经黑色素激活时会触发多巴胺能神经退行性变。 |
Blasco-Agell, L. |
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LRRK2-mutant microglia trigger dopaminergic neurodegeneration when activated by neuromelanin |
| 急性GARP耗竭会破坏囊泡运输，导致分拣、分泌和O-糖基化出现严重缺陷。 |
Khakurel, A. |
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Acute GARP depletion disrupts vesicle transport leading to severe defects in sorting, secretion, and O-glycosylation |