| 多切片空间转录组学数据在二维和三维中的自动化整合 |
Bienroth, D. |
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Automated Integration of Multi-Slice Spatial Transcriptomics Data in 2D and 3D |
| 倒位可以积累平衡的性对抗：来自模拟和果蝇实验的证据 |
McAllester, C. S. |
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Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments |
| 冬眠会减少脑干中的GABA信号传导，以增强在低温下的呼吸运动活动。 |
Saunders, S. E. |
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Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures |
| 表观遗传的细胞可塑性遗传性通过一对多的基因型到表型映射驱动了癌症药物的抗性。 |
Fernandez-Mateos, J. |
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Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping |
| TML1与TML2协同调控苜蓿根瘤形成并影响丛枝菌根共生 |
Chaulagain, D. |
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TML1 AND TML2 SYNERGISTICALLY REGULATE NODULATION AND AFFECT ARBUSCULAR MYCORRHIZA IN MEDICAGO TRUNCATULA |
| 临床批准的BTK抑制剂对全长BTK构象的影响及慢性淋巴细胞白血病中BTK耐药突变的发展分析。 |
Joseph, R. E. |
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Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia. |
| 用于从纳米孔直接RNA测序数据估计RNA修饰的原始信号分割 |
Cheng, G. |
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Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data |
| 一种新型人多能干细胞基因激活系统鉴定出IGFBP2为体外造血祖细胞生成的中介因子 |
Petazzi, P. |
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A novel human pluripotent stem cell-based gene activation system identifies IGFBP2 as a mediator in the production of hematopoietic progenitors in vitro |
| 时间尺度与遗传连锁解释了防御系统对横向基因转移影响的可变性 |
Liu, Y. |
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Timescales and genetic linkage explain the variable impact of defense systems on horizontal gene transfer |
| 实蝇科中的嗅觉：检测与辨别之间的平衡 |
Ramiaranjatovo, G. |
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Olfaction in Tephritidae: a balance between detection and discrimination |
| 蛋白质组动态揭示Leiomodin 1是肌源性分化的关键调控因子 |
Spath, E. |
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Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation |
| Ais：简化冷冻电子断层扫描数据集的分割流程 |
Last, M. G. F. |
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Ais: streamlining segmentation of cryo-electron tomography datasets |
| WENDY：基于协方差动态的基因调控网络推断 |
Wang, Y. |
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WENDY: Covariance Dynamics Based Gene Regulatory Network Inference |
| 在小鼠新皮质中，对局部创伤性脑损伤的大规模和细胞反应的成像 |
Bibineyshvili, Y. |
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Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex |
| 通过顺式调控机制靶向三阴性乳腺癌中的昼夜节律转录程序 |
Pan, Y. |
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Targeting circadian transcriptional programs in triple negative breast cancer through a cis-regulatory mechanism |
| 从C3向C4光合作用进化的过程是由 |
Yongyao, Z. |
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The process that the evolution from C3 towards C4 photosynthesis is driven |
| 同源自然杀伤细胞疗法激活了转移肺中的树突状细胞和T细胞，并有效治疗了低负荷的转移病灶。 |
Huang, S.-W. |
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Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases |
| 环境与环境之间的相互作用（ExE）在不同的遗传背景下（ExExG）有所不同。 |
Schmidlin, K. |
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Environment by environment interactions (ExE) differ across genetic backgrounds (ExExG) |
| Piximi - 一个用于生物图像及更广泛领域的图像发现网络工具 |
Moser, L. M. |
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Piximi - An Images to Discovery web tool for bioimages and beyond |
| 有效的抗肿瘤免疫反应是由免疫细胞合作网络所调控的，该网络通过组织稳态通路发挥作用，而非直接的细胞毒性作用。 |
Koelsch, N. |
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Effective anti-tumor immune responses are orchestrated by immune cell partnership network that functions through tissue homeostatic pathways, not direct cytotoxicity |
| 通过动态力学刺激增强细胞质中外源mRNA的表达 |
Chen, J. |
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Enhancing Cytoplasmic Expression of Exogenous mRNA through Dynamic Mechanical Stimulation |
| 染色质内源性切割提供了一种对酵母RNA聚合酶II转录动力学的全局视角。 |
VanBelzen, J. |
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Chromatin endogenous cleavage provides a global view of yeast RNA polymerase II transcription kinetics |
| 探索不同处理对受橄榄疫霉（Phytophthora oleae）影响的橄榄（Olea europaea L.）果实基因表达的影响：基于RNA测序的转录组分析的见解。 |
Conti Taguali, S. |
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Exploring the Impact of Various Treatments on Gene Expression in Olive (Olea europaea L.) Drupes Affected by Phytophthora oleae: Insights from RNA sequencing-based transcriptome analysis. |
| 时间动态分析揭示，同时进行的工作记忆负荷通过破坏刺激-反应映射消除了斯特鲁普效应。 |
Li, Y. |
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Temporal dynamics analysis reveals that concurrent working memory load eliminates the Stroop effect through disrupting stimulus-response mapping |
| 质粒病毒维持使细菌种群从感染中恢复，并实现病毒与细菌的共存。 |
Sanchez-Martinez, R. |
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Episomal virus maintenance enables bacterial population recovery from infection and virus-bacterial coexistence |
| 预测动态控制精确绘制了2,3-丁二醇生产的设计空间 |
Gotsmy, M. |
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Predictive Dynamic Control Accurately Maps the Design Space for 2,3-Butanediol Production |
| SpinalTRAQ：一种新颖的颈椎脊髓体积图谱，用于识别健康和卒中后小鼠的皮质脊髓束突触投射体 |
Poinsatte, K. |
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SpinalTRAQ: A novel volumetric cervical spinal cord atlas identifies the corticospinal tract synaptic projectome in healthy and post-stroke mice |
| 利用扩增子测序技术将微生物群落结构与功能联系起来：基于干旱胁迫下与小麦根系相关的NRPS基因的研究 |
Guan, Y. |
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Linking microbial community structure with function using amplicon sequencing of the NRPS genes associated with wheat roots under drought stress |
| SARS-CoV-2主蛋白酶活性位点环的构象空间由配体结合和蛋白质间别构效应决定。 |
Lee, E. |
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The Conformational Space of the SARS-CoV-2 Main Protease Active Site Loops is Determined by Ligand Binding and Interprotomer Allostery |
| 从基因到模式：一个建模胚胎发育从转录调控中涌现的框架 |
Garcia-Guillen, J. |
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From Genes to Patterns: A Framework for Modeling the Emergence of Embryonic Development from Transcriptional Regulation |
| 在裂殖酵母中，细胞质内的扩散随着细胞大小的增加而增加。 |
Tan, C. |
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Intracellular diffusion in the cytoplasm increases with cell size in fission yeast |
| 慢性使用氟西汀会下调前额叶皮质中小清蛋白中间神经元的线粒体活性。 |
Jetsonen, E. |
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Chronic treatment with fluoxetine downregulates mitochondrial activity in parvalbumin interneurons of prefrontal cortex |
| ALG-1，一种microRNA的Argonaute蛋白，促进秀丽隐杆线虫的生殖器诱导。 |
Zhen, S. |
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ALG-1, a microRNA argonaute, promotes vulva induction in C. elegans |
| 钾通道模拟中的电荷缩放：电导、离子占据、电压响应与选择性 |
Hui, C. |
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Charge Scaling in Potassium Channel Simulations: Conductance, Ion Occupancy, Voltage Response, and Selectivity |
| 新型烈性噬菌体对小鼠鲍曼不动杆菌急性肺部感染的疗效与安全性 |
Wang, J. |
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Efficacy and Safety of a novel virulent phage against acute pulmonary infection of Acinetobacter baumanniii in mice |
| 基于多组分硫内酯的可电离脂质筛选平台，用于高效且可调节的mRNA向肺部的递送 |
Pena, A. |
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Multicomponent Thiolactone-Based Ionizable Lipid Screening Platform for an Efficient and Tunable mRNA Delivery to the Lungs |
| 18q的缺失改变了TGFβ信号传导，影响了人胚胎干细胞的前后神经外胚层命运 |
Lei, Y. |
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Loss of 18q alters TGFβ signalling affecting anteroposterior neuroectodermal fate in human embryonic stem cells |
| TRIM37利用肽基序识别和底物依赖性寡聚化来防止异常的纺锤体极组装。 |
Bellaart, A. |
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TRIM37 employs peptide motif recognition and substrate-dependent oligomerization to prevent ectopic spindle pole assembly |
| TOMM40-APOE嵌合体关联阿尔茨海默病最高风险基因：线粒体调控与APOE4发病机制的新途径 |
Xu, J. |
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TOMM40-APOE chimera linking Alzheimer's highest risk genes: a new pathway for mitochondria regulation and APOE4 pathogenesis |
| 在果蝇癌细胞模型中，细胞集体脱层的方向性受组织结构和细胞粘附的调控。 |
MIRA OSUNA, M. |
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The directionality of collective cell delamination is governed by tissue architecture and cell adhesion in a Drosophila carcinoma model |
| EPHA2在食管发育过程中调控SOX2 |
Li, T. |
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EPHA2 Regulates SOX2 during Esophageal Development |
| 失去青鳉鱼cGAS/STING功能减轻了细胞衰老和与年龄相关的特征，但并未延长生物体的寿命。 |
Ballhysa, E. |
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Loss of killifish cGAS/STING function attenuates cellular senescence and age-related signatures but does not extend organismal life span |
| 增强型RNA靶向CRISPR-Cas技术在斑马鱼中的应用 |
Moreno-Sanchez, I. |
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Enhanced RNA-targeting CRISPR-Cas technology in zebrafish |
| 儿童呼吸道病毒感染的局部和全身免疫反应的蛋白质组学分析 |
Lydon, E. |
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N/A |
Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections |
| assessPool: 一个用于群体基因组分析的灵活管道，适用于合并测序数据 |
Freel, E. B. |
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assessPool: a fexible pipeline for population genomic analyses of pooled sequencing data |
| 亚热带和热带植物物种独特的地下生态策略拓展了根系特征空间 |
Guerrero Ramirez, N. R. |
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Unique belowground ecological strategies of subtropical and tropical plant species expand the root trait space |
| 农业集约化导致的遗传多样性丧失和遗传负荷积累的物种特异性 |
Nolen, Z. J. |
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Species-specific loss of genetic diversity and accumulation of genetic load following agricultural intensification |
| 注射型Janus基底纳米矩阵（JBNm）在维持再生软骨长期体内平衡中的作用，适用于组织芯片应用 |
Yau, A. |
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Injectable Janus Base Nanomatrix (JBNm) in Maintaining Long-Term Homeostasis of Regenerated Cartilage for Tissue Chip Applications |
| 使用环保溶剂增强光交联丝素蛋白的多功能性 |
Brooks, A. K. |
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N/A |
Enhancing the versatility of photocrosslinkable silk fibroin using an eco-friendly solvent |
| 人子宫组织电活动的有限元建模：模拟技术的进展 |
Zahran, S. |
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N/A |
Finite Element Modeling of Electrical Activity in Human Uterine Tissue: Advances in Simulation Techniques |
| 从非靶向代谢组学数据中直接经验性地建立药物暴露记录 |
Zhao, H. N. |
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Empirically establishing drug exposure records directly from untargeted metabolomics data |
| 工程化年龄模拟乳腺癌模型揭示了年轻和衰老微环境中药物反应的差异 |
Yang, J. |
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Engineered Age-Mimetic Breast Cancer Models Reveal Differential Drug Responses in Young and Aged Microenvironments |
| 利用MORFEE增强小ORF改变变异的注释：引入MORFEEdb，一个全面的人类5'UTR上游ORF受影响SNV目录 |
Meguerditchian, C. |
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N/A |
Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5'UTRs |
| 生物信息学分析表明，表皮葡萄球菌（Staphylococcus epidermidis）的SE_1780蛋白可能是脂肪酶Fph家族的成员。 |
Qaddourah, M. |
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Bioinformatics Analysis Suggests That SE_1780 protein from Staphylococcus epidermidis may be a member of the Fph Family of Lipases |
| 蛋白质结构预测的终结：通过窗口化多序列比对提高嵌合蛋白质的预测准确性 |
Vedula, S. |
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N/A |
The end of protein structure prediction: Improving prediction accuracy in chimeric proteins by windowed multiple sequence alignment |
| James-Stein估计器提高了人体运动学和代谢数据中的准确性和样本效率。 |
Alwan, A. |
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James-Stein estimator improves accuracy and sample efficiency in human kinematic and metabolic data |
| 假单胞菌属内竞争决定了共生体在拟南芥中的保护功能 |
Amrhein, A. |
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Pseudomonas intra-genus competition determines protective function of SynComs in Arabidopsis thaliana |
| 拟南芥莽草酸途径中的3-脱氧-D-阿拉伯糖-庚酮糖酸-7-磷酸（DAHP）合酶表现出依赖锰和钴的活性。 |
Yokoyama, R. |
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N/A |
Arabidopsis 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthases of the shikimate pathway display both manganese- and cobalt-dependent activities |
| 低强度聚焦超声神经调节揭示了丘脑在意识知觉中的作用 |
Jang, H. |
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N/A |
Thalamic Roles in Conscious Perception Revealed by Low-Intensity Focused Ultrasound Neuromodulation |
| 感知和图像记忆中的时间动态和读出延迟 |
Matic, K. |
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N/A |
Temporal dynamics and readout latency in perception and iconic memory |
| 深海鱼类揭示了脊椎动物视觉发育的替代途径 |
Fogg, L. G. |
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N/A |
Deep-sea fish reveal alternative pathway for vertebrate visual development |
| 通过细胞膜蛋白工程改造脂质体以破坏黑素小体转移 |
Liu, C. |
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N/A |
Engineering liposomes with cell membrane proteins to disrupt melanosome transfer |
| 在计算机模拟中，胶原蛋白-IV网络的非平衡重塑 |
Meadowcroft, B. |
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N/A |
Non-equilibrium remodelling of collagen-IV networks in silico |
| 硅和生物玻璃纳米材料在类髓质活体材料中的评估 |
Mbitta Akoa, D. |
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N/A |
Evaluation of Silica and Bioglass Nanomaterials in Pulp-Like Living Materials |
| 哈弗氏管内骨小梁的矿化程度取决于哈弗氏管的形成位置 |
Cantamessa, A. |
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N/A |
The mineralization of osteonal cement line depends on where the osteon is formed |
| 一种水动力天线：蝠鲼尾部的新型侧线系统 |
Cerda, J. C. |
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N/A |
A hydrodynamic antenna: novel lateral line system in the tail of myliobatid stingrays |
| 大规模饲养食用昆虫Gryllodes sigillatus（直翅目：蟋蟀科）的生长、发育及生活史 |
Kong, J. D. |
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N/A |
Growth, development, and life history of a mass-reared edible insect, Gryllodes sigillatus (Orthoptera: Gryllidae) |
| 使用SNAP标签对Munc13-1进行内源性标记，作为监测突触纳米结构的工具 |
Kowald, M. |
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N/A |
Endogenous tagging of Munc13-1 with a SNAP tag as a tool for monitoring synapse nanoarchitecture |
| 序列学习中的声音与景象：辅助听觉提示能否提升运动任务表现？ |
Leow, L.-A. |
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N/A |
Sounds and Sights in Sequence Learning: Can Accessory Auditory Cues Enhance Motor Task Performance? |
| 半胱氨酸蛋白酶抑制剂E-64的生物合成特性及组合生物催化研究 |
Liu, M. |
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N/A |
Biosynthetic characterization and combinatorial biocatalysis of the cysteine protease inhibitor E-64 |
| 体外转录RNA的化学环化为环状mRNA设计开辟了新的途径 |
Mamot, A. |
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N/A |
Chemical circularization of in vitro transcribed RNA opens new avenues for circular mRNA design |
| 对选择性和双重拮抗EP2和EP4前列腺素受体的结构洞察 |
Wu, Y. |
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N/A |
Structural Insights into Selective and Dual Antagonism of EP2 and EP4 Prostaglandin Receptors |
| 利用GSMMs和多组学方法改进基于HEK293的AAV生产 |
Zehetner, L. |
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N/A |
Improving HEK293-based AAV-production using GSMMs, and a multi-omics approach |
| 通过环挤出介导的刚性可以在全局范围内有序细菌染色体 |
Harju, J. |
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N/A |
Loop-extruder mediated rigidity can globally order bacterial chromosomes |
| 高吞吐量根癌农杆菌介导的植物转化半自动化工作流程 |
Annese, D. |
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N/A |
Semi-automated workflow for high-throughput Agrobacterium-mediated plant transformation |
| 球形细胞：改变硅藻DNA传递的游戏规则 |
Walker, E. J. L. |
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N/A |
Spheroplasted cells: a game changer for DNA delivery to diatoms |
| 深度突变扫描识别出能够提高II型-A CRISPR-Cas系统中间隔序列获取的Cas1和Cas2变体 |
Hofmann, R. |
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N/A |
Deep mutational scanning identifies variants of Cas1 and Cas2 that increase spacer acquisition in type II-A CRISPR-Cas systems |
| 通过冷冻电镜分析揭示的二元毒素孔道逐步成熟机制 |
Yamada, T. |
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N/A |
Step-by-Step Maturation Mechanism of Binary Toxin Pore Revealed by Cryo-EM Analysis |
| 双链DNA减少了唾液中dsRNA的降解，并显著增强了RNAi介导的Halyomorpha halys基因沉默效果。 |
Amineni, V. P. S. |
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N/A |
Double-stranded DNA reduces dsRNA degradation in the saliva and significantly enhanced RNAi-mediated gene silencing in Halyomorpha halys |
| 芒果苷作为甲状腺素纤维化潜在抑制剂的研究 |
Grudinina, N. |
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N/A |
MANGIFERIN AS A POTENTIAL INHIBITOR OF TRANSTHYRETIN FIBRILOGENESIS |
| 肿瘤抑制性miR-317和长链非编码RNA Peony源自一个多顺反子非编码RNA位点，该位点调控生殖系分化和睾丸形态。 |
Carney, T. D. |
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N/A |
Tumor suppressor miR-317 and lncRNA Peony are expressed from a polycistronic non-coding RNA locus that regulates germline differentiation and testis morphology |
| CCG中断在DM1患者中不稳定且呈现高甲基化状态。 |
Lameiras, S. |
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N/A |
CCG interruptions are unstable and hypermethylated in DM1 patients |
| 两种人群中抗锥虫突变的新发率 |
Melamed, D. |
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N/A |
De novo rates of a Trypanosoma-resistant mutation in two human populations |
| 记者CRISPR筛选揭示了Xist位点的顺式和反式调控原理 |
Schwaemmle, T. |
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N/A |
Reporter CRISPR screens decipher cis- and trans-regulatory principles at the Xist locus |
| 鉴定拟南芥当地自然种群中存在的一种花粉杀手的相关新基因 |
Ricou, A. |
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N/A |
Identification of novel genes responsible for a pollen killer present in local natural populations of Arabidopsis thaliana |
| CRISPR 平铺缺失筛选揭示了神经精神风险基因的功能增强子和转录的等位补偿效应（ACE） |
Ren, X. |
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N/A |
CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription |
| 通过邻近条形码测序同时映射多种RNA修饰 |
Sendinc, E. |
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N/A |
Mapping multiple RNA modifications simultaneously by proximity barcode sequencing |
| 小鼠着丝粒和副着丝粒的基因组和表观基因组图谱 |
Chaudhry, G. |
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N/A |
Genomic and epigenomic maps of mouse centromeres and pericentromeres |
| 在荷兰一座城市植物园的Asparagales植物中发现了新的和变种的马铃薯Y病毒 |
Dekker, R. J. |
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N/A |
Discovery of new and variant Potyviruses in Asparagales plants from a Dutch urban botanic garden |
| 心磷脂缺乏会破坏辅酶Q的氧化还原状态并引发脂肪性肝炎 |
Brothwell, M. J. |
PDF |
N/A |
Cardiolipin deficiency disrupts CoQ redox state and induces steatohepatitis |
| 通过SpyTag硫酰胺取代调节SpyCatcher连接动力学 |
Fiore, K. |
PDF |
N/A |
Modulation of SpyCatcher Ligation Kinetics by SpyTag Thioamide Substitution |
| 2.6-A分辨率的冷冻电镜结构显示了Ia类核糖核苷酸还原酶与基于机制的抑制剂N3CDP结合的复合物 |
Westmoreland, D. E. |
PDF |
N/A |
2.6-A resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor N3CDP |
| DNA聚合酶在压力下锁定复制叉 |
Jia, X. |
PDF |
N/A |
DNA Polymerase Locks Replication Fork Under Stress |
| SIRT7与核小体结合及其底物特异性的结构基础 |
Moreno Yruela, C. |
PDF |
N/A |
Structural basis of SIRT7 nucleosome engagement and substrate specificity |
| 圆环DNA的扭转力学 |
Singh, G. |
PDF |
N/A |
Torsional Mechanics of Circular DNA |
| Sanfetrinem是一种口服的β-内酰胺抗生素，被重新用于结核病的治疗。 |
Ramon-Garcia, S. |
PDF |
N/A |
Sanfetrinem, an oral beta-lactam antibiotic repurposed for the treatment of tuberculosis |
| 杂合和广谱的MxA超级限制因子克服了抗病毒限制中的广度特异性权衡 |
Geiger, R. A. |
PDF |
N/A |
Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction |
| 核心微生物组的系统发育测量 |
Bewick, S. A. |
PDF |
N/A |
Phylogenetic Measures of the Core Microbiome |
| 绣球属植物天然甜味剂生物合成途径的解析与功能鉴定 |
Padmakumar Sarala, G. |
PDF |
N/A |
Elucidation and functional characterization of natural sweetener biosynthesis in hortensia species |
| 寄生线虫Heligmosomoides bakeri中机会性吸血行为的证据 |
Szabo, E. K. |
PDF |
N/A |
Evidence of opportunistic blood feeding in the parasitic nematode Heligmosomoides bakeri |
| 在人类照料下的一种极度濒危的两栖动物中，精子质量指标表现出年度波动。 |
Julien, A. R. |
PDF |
N/A |
Sperm quality metrics exhibit annual fluctuations in a critically endangered amphibian managed under human care |
| 自然干扰和连通性塑造了欧洲水生大型无脊椎动物群落季节性变化的格局 |
Chalmandrier, L. |
PDF |
N/A |
Natural disturbances and connectivity shape the seasonal variability of aquatic macroinvertebrate communities across Europe |