| GEARBOCS：一种用于星形胶质细胞体内基因编辑的腺相关病毒工具 |
Sivadasan Bindu, D. |
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GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes |
| 系统性创建和表型分析在秀丽隐杆线虫中的孟德尔疾病模型：迈向大规模药物再利用 |
O'Brien, T. J. |
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N/A |
Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing |
| SIMVI揭示了空间组学数据中的内在状态和空间诱导状态 |
Dong, M. |
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SIMVI reveals intrinsic and spatial-induced states in spatial omics data |
| 通过顺序采样构建价值解释了决策中的序列依赖性 |
Zylberberg, A. |
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Value construction through sequential sampling explains serial dependencies in decision making |
| 年轻和年长成人在注意定向期间的心跳诱发电位 |
Aprile, F. |
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The heartbeat-evoked potential in young and older adults during attention orienting |
| 针对异染色质消除恶性干细胞通过重新激活逆转录元件和先天免疫途径在慢性粒单核细胞白血病中的作用 |
Hidaoui, D. |
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Targeting Heterochromatin Eliminates Malignant Stem Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways |
| 查尔酮和吡唑啉衍生物的合成及其作为ELF3-MED23相互作用新型抑制剂的生物学评估 |
Hwang, S.-Y. |
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Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as novel inhibitor for ELF3-MED23 Interaction |
| AlphaFold2在二聚体、三聚体和四聚体卷曲螺旋结构域建模中的适用性 |
Madaj, R. |
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N/A |
Applicability of AlphaFold2 in the modeling of dimeric, trimeric, and tetrameric coiled-coil domains |
| 异质性和高阶皮质连接支撑着高效、稳健且可靠的神经编码。 |
Egas Santander, D. |
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Heterogeneous and higher-order cortical connectivity undergirds efficient, robust and reliable neural codes |
| 一种分子开关调控着人类信使RNA的核外输出 |
Hohmann, U. |
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A molecular switch orchestrates the nuclear export of human messenger RNA |
| 视觉识别深度神经网络的反复问题 |
Maniquet, T. |
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Recurrent issues with deep neural networks of visual recognition |
| 在尖峰神经肌肉模型中，平衡中央控制与感觉反馈能产生适应性强且稳健的蝾螈脊髓运动模式。 |
Pazzaglia, A. |
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Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord |
| 拉特伦库利德海绵中独特而神秘的螺旋体共生体 |
Waterworth, S. C. |
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The unique and enigmatic spirochete symbiont of latrunculid sponges |
| 模拟显示，法尼醇X受体（FXR）铰链在FXR-RXR核受体异二聚体中扮演着独特的角色。 |
Yu, T. |
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Simulations reveal unique roles for the FXR hinge in the FXR-RXR nuclear receptor heterodimer |
| 线粒体功能障碍：揭示溃疡性结肠炎期间抗TNF反应背后的生物学机制 |
Kioroglou, D. |
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Mitochondrial dysfunction: unraveling the elusive biology behind anti-TNF response during ulcerative colitis |
| 在异源二倍体和四倍体群体中，基因组预测杂种优势、近交控制及配对分配 |
Endelman, J. B. |
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Genomic prediction of heterosis, inbreeding control, and mate allocation in outbred diploid and tetraploid populations |
| 巨噬细胞中脂肪酸的摄入或分解代谢受损会限制结核分枝杆菌的胞内生长。 |
Simwela, N. V. |
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Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis |
| 蛋白质表面化学编码了一种对干燥的适应性耐受性 |
Romero-Perez, P. S. |
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Protein Surface Chemistry Encodes an Adaptive Tolerance to Desiccation |
| 含有强效LILRB1 D1D2的抗体可抑制RIFIN介导的免疫逃避 |
Wang, Y. |
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Potent LILRB1 D1D2-containing antibodies inhibit RIFIN-mediated immune evasions |
| SynDRep：一种基于协同伙伴预测的药物重定位知识图谱增强工具 |
Shalaby, K. S. |
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SynDRep: A Knowledge Graph-Enhanced Tool based on Synergistic Partner Prediction for Drug Repurposing |
| 重新思考大规模系统基因组学：PhyloToL 6，一个灵活的工具包，用于实现基于系统发育的数据管理和分析 |
Cote-L'Heureux, A. E. |
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Rethinking large scale phylogenomics with PhyloToL 6, a flexible toolkit to enable phylogeny-informed data curation and analysis |
| 旁分泌拯救MYR1缺陷型刚地弓形虫突变体揭示了体内CRISPR筛选的局限性 |
Torelli, F. |
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Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens |
| 大型丝氨酸整合酶脱靶发现与验证用于治疗性基因组编辑 |
Hazelbaker, D. Z. |
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Large Serine Integrase Off-target Discovery and Validation for Therapeutic Genome Editing |
| 利用跨试验和行为会话的相关性来改进神经解码 |
Zhang, Y. |
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Exploiting correlations across trials and behavioral sessions to improve neural decoding |
| 使用深度学习和基于物理的专家混合进行稳健的RNA二级结构预测 |
Qiu, X. |
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Robust RNA Secondary Structure Prediction with a Mixture of Deep Learning and Physics-based Experts |
| 前额叶皮层中的视觉运动神经元进行的贝叶斯推理 |
Langlois, T. |
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Bayesian inference by visuomotor neurons in prefrontal cortex |
| 模块化表示出现在经过训练以执行依赖于上下文的任务的神经网络中 |
Johnston, W. J. |
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Modular representations emerge in neural networks trained to perform context-dependent tasks |
| 动物声学交流保持着一种普遍的最优节奏 |
Piette, T. |
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Animal acoustic communication maintains a universal optimum rhythm |
| 生物信息学：整合负对照以获得优质数据 |
van Nues, R. W. |
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Bio-informatics: Integrate negative controls to get the good data |
| 哥伦比亚大西洋省韦莱罗港高沉积物水域中珊瑚种群及其相关生物的空前发现 |
Moreno Tilano, J. A. |
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Unprecedented sighting of coral populations and associated fauna in the High Sedimentation Waters of Puerto Velero, Atlantico, Colombia |
| 雌激素缺乏改变血管化和矿化动力学：来自新型三维人源化和血管化骨类器官模型的见解 |
Bukhari, M. M. M. |
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Estrogen Deficiency alters Vascularization and Mineralization dynamics: insight from a novel 3D Humanized and Vascularized Bone Organoid Model |
| 剖析人类诱导多能干细胞模型中MASLD进展过程中的复合肝细胞损伤 |
Weihs, J. |
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Dissecting compounded hepatocyte injury in a model of MASLD progression from human induced pluripotent stem cells |
| 小GTP酶Ran定义了核孔复合物的非对称性。 |
Sachweh, J. |
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The small GTPase Ran defines Nuclear Pore Complex asymmetry |
| cGAS缺陷小鼠表现出与LINE1元件去抑制和炎症相关的早衰现象。 |
Martinez, J. C. |
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cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation |
| 一种非典型的E3泛素连接酶在营养压力期间保护核糖体 |
Douglas, T. |
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An atypical E3 ligase safeguards the ribosome during nutrient stress |
| BBSome的功能多样化：来自蜜蜂锥虫寄生虫Lotmaria passim的见解 |
Yuan, X. |
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Functional diversification of the BBSome: Insights from honey bee trypanosomatid parasite, Lotmaria passim |
| Plexin/Semaphorin拮抗作用通过接触间充质化调控集体细胞迁移、间隙闭合和器官塑形 |
Bischoff, M. C. |
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Plexin/Semaphorin Antagonism Orchestrates Collective Cell Migration, Gap Closure and Organ sculpting by Contact-Mesenchymalization |
| Nth-like DNA糖基化酶对线粒体动力学的影响 |
Hubers, L. A. |
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Functional Impact of Nth-like DNA glycosylase on Mitochondrial Dynamics |
| GPR87在肺纤维化中的作用 |
Khoury, J. |
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The role of GPR87 in Pulmonary Fibrosis |
| Danicamtiv通过减少肌球蛋白的工作冲程，同时激活细丝来增强收缩。 |
Scott, B. |
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Danicamtiv reduces myosin's working stroke but enhances contraction by activating the thin filament |
| 配体结合的TRPV1异质性：冷冻电镜与分子动力学模拟方法的比较 |
Astore, M. A. |
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Heterogeneity in ligand-bound TRPV1: A comparison of methods in cryo-EM and molecular dynamics simulation |
| 骨髓基质细胞之间的隧道纳米管支持传递自噬和多发性骨髓瘤的抗凋亡作用。 |
Solimando, A. G. |
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Tunneling Nanotubes Between Bone Marrow Stromal Cells Support Transmitophagy and Resistance to Apoptosis in Myeloma |
| 绘制接受氟达拉滨治疗的白血病细胞的空间蛋白质组图谱 |
Globisch, M. A. |
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Mapping the Spatial Proteome of Leukemia Cells Undergoing Fludarabine Treatment |
| 细胞外谷胱甘肽的分解代谢为肿瘤生长提供了氨基酸支持。 |
Hecht, F. |
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Catabolism of extracellular glutathione supplies amino acids to support tumor growth |
| 一项大规模的反向遗传学筛选鉴定出多个调控睾丸新生肌管集体细胞迁移和集体器官塑形的调控因子 |
Bischoff, M. C. |
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A large reverse-genetic screen identifies numerous regulators of testis nascent myotube collective cell migration and collective organ sculpting |
| 货物适配器身份控制驱动蛋白激活的机制和动力学 |
Gillies, J. P. |
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Cargo adaptor identity controls the mechanism and kinetics of dynein activation |
| FUDR的磷酰胺酸修饰物NUC-3373，可导致结直肠癌细胞DNA损伤并释放损伤相关分子模式（DAMPs），从而增强淋巴细胞诱导的细胞死亡。 |
read, o. |
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N/A |
A phosphoramidate modification of FUDR, NUC-3373, causes DNA damage and DAMPs release from colorectal cancer cells, potentiating lymphocyte-induced cell death |
| 从福尔马林固定石蜡包埋（FFPE）样本中进行可靠的RNA测序分析，作为加速癌症相关健康差异研究的一种手段 |
Sandulache, V. |
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N/A |
Reliable RNA-seq analysis from FFPE specimens as a means to accelerate cancer-related health disparities research |
| 从福尔马林固定石蜡包埋（FFPE）样本中进行可靠的RNA测序分析，作为加速癌症相关健康差异研究的一种手段 |
Sandulache, V. |
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N/A |
Reliable RNA-seq analysis from FFPE specimens as a means to accelerate cancer-related health disparities research |
| 甲状腺癌中可靶向治疗的耐药性与克隆性造血相关 |
Tiedje, V. |
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Targetable Treatment Resistance in Thyroid Cancer with Clonal Hematopoiesis |
| 富含多酚的岩白菜（Bergenia ligulata (Wall.) Engl.）提取物在体内增强结肠和乳腺癌转移：细胞类型特异性机制的证据 |
De, S. |
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Polyphenol-rich fraction of Bergenia ligulata (Wall.) Engl. sensitizes colon and breast cancer metastasis in vivo: Evidence of cell-type specific mechanism |
| 易位可以驱动调控子中多个基因的表达变化，这些调控子覆盖整个染色体臂。 |
Oncins, A. |
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Translocations can drive expression changes of multiple genes in regulons covering entire chromosome arms |
| PKCtheta-GADD45a轴的丧失促使三阴性乳腺癌细胞进入p53非依赖性衰老状态。 |
Nicolle, A. |
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Loss of PKCtheta-GADD45a axis drives triple-negative breast cancer cells into p53-independent senescence |
| CXCR4部分激动剂通过靶向多形核髓源性抑制细胞和癌症驱动的粒细胞生成，改善了免疫疗法的效果。 |
Qian, J. |
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A CXCR4 partial agonist improves immunotherapy by targeting polymorphonuclear myeloid-derived suppressor cells and cancer-driven granulopoiesis |
| 基于性别和年龄的小鼠原代腹膜间皮细胞蛋白质组特征分析与比较 |
Wang, Z. |
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N/A |
Gender- and Age-Based Characterization and Comparison of the Murine Primary Peritoneal Mesothelial Cell Proteome |
| 癌症mRNA翻译特异性介质的筛选 |
Kovalski, J. R. |
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N/A |
Functional screen for mediators of onco-mRNA translation specificity |
| 别构降解剂诱导CRL5ASB8介导的XPO1降解 |
Hudman-Wing, C. E. |
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Allosteric degraders induce CRL5ASB8 mediated degradation of XPO1 |
| 利用胰凝乳蛋白酶水解法挖掘人类卵巢癌外泌体的蛋白质组 |
Cooper, T. T. |
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N/A |
Mining the Proteome of Human Ovarian Cancer Extracellular Vesicles Using Thermolysin Proteolysis |
| 胰岛素抵抗性肥胖中的血浆外泌体加剧三阴性乳腺癌的进展 |
Llevenes, P. |
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N/A |
Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast Cancer |
| Mgat4b介导的选择性N-糖基化调控黑素细胞发育及黑色素瘤进展 |
Natarajan, V. T. |
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Mgat4b mediated selective N-glycosylation regulates melanocyte development and melanoma progression |
| 一种肿瘤胚胎学方法揭示了SoxC驱动的结肠发育和癌症调控 |
Dalessi, T. |
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An oncoembryology approach uncovers SoxC-driven regulation of colon development and cancer |
| H2AK119ub动力学控制毛囊干细胞静息状态 |
Flora, P. |
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H2AK119ub dynamics controls hair follicle stem cell quiescence |
| 人类和大猩猩视网膜蓝锥光感受器外节中的全长隐花色素1表明其作用不仅仅局限于转录抑制。 |
Bartoelke, R. |
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Full-length Cryptochrome 1 in the outer segments of the retinal blue cone photoreceptors in humans and great apes suggests a role beyond transcriptional repression |
| 一种结直肠癌中三级淋巴结构数字表征的新方法 |
Munoz-Erazo, L. |
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N/A |
A novel approach to digital characterisation of Tertiary Lymphoid Structures in colorectal cancer |
| 鉴定DLK1（一种Notch配体）作为免疫治疗靶点及调节肾上腺皮质癌肿瘤细胞可塑性和化学抗性的作用 |
Sun, N.-Y. |
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Identification of DLK1, a Notch ligand, as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma |
| 由于谱系依赖的干细胞和祖细胞上的生长抑素受体表达，放射性诊断概念在神经内分泌肿瘤中的局限性 |
Nguyen, N. |
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Limitations of the radiotheranostic concept in neuroendocrine tumors due to lineage-dependent somatostatin receptor expression on hematopoietic stem and progenitor cells |
| 抑制雄激素受体暴露了前列腺癌的复制应激脆弱性 |
Williams, C. S. |
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Inhibition of Androgen Receptor Exposes Replication Stress Vulnerability in Prostate Cancer |
| 遗传数据指导下的卵巢癌最佳治疗方案 |
Mertzios, A. |
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N/A |
Optimal Prescriptive Treatments for Ovarian Cancer with Genetic Data |
| 从年轻和年老小鼠中建立永生化的棕色和白色前脂肪细胞系 |
Wu, X. |
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N/A |
Establishing immortalized brown and white preadipocyte cell lines from young and aged mice |
| 一种新型GelMA-OrnMA电导性生物墨水用于开发工程化神经组织 |
Sakr, M. |
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A Novel GelMA-OrnMA Electrically Conductive Bioink for Developing Engineered Neural Tissues |
| 解开金丝桃素的潜力：一种针对胆固醇管理中PCSK9突变的新方法 |
FERRARI, I. V. |
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Unraveling the Potential of Hypericin: A Novel Approach to Targeting PCSK9 Mutations in Cholesterol Management |
| 基准测试基于序列和基于AlphaFold的方法用于pMHC-II结合核心预测：各自的优势与共识方法 |
Ko, S. |
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Benchmarking Sequence-Based and AlphaFold-Based Methods for pMHC-II Binding Core Prediction: Distinct Strengths and Consensus Approaches |
| 利用预测的噬菌体宿主信息改进肠道噬菌体群落比较 |
Shamash, M. |
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N/A |
Improving gut virome comparisons using predicted phage host information |
| 蛋白质聚集以特定尺寸的方式驱动大肠杆菌细胞的衰老 |
Wagener, L. |
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N/A |
Protein aggregation drives cell aging in a size-specific manner in Escherichia coli |
| 在魏斯曼式和拉马克式继承的连续体上，文化复制的一个达尔文模型 |
Zachar, I. |
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N/A |
A Darwinian model of cultural replication over the continuum of Weismannian and Lamarckian inheritance |
| 不同血管区对脑自动调节和功能性充血的深度依赖性贡献：一项模拟分析 |
Pashaie, R. |
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N/A |
Depth-Dependent Contributions of Various Vascular Zones to Cerebral Autoregulation and Functional; Hyperemia: An In-Silico Analysis |
| 提高生成化学中分子字符串表示的可靠性 |
Reboul, E. |
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N/A |
Improving the reliability of molecular string representations for generative chemistry |
| 数据驱动评估适用于改进抗体选择的合适免疫原 |
Waury, K. |
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N/A |
Data-driven evaluation of suitable immunogens for improved antibody selection |
| Vispro 提升了 Visium 空间转录组学成像分析的效果。 |
Ma, H. |
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Vispro improves imaging analysis for Visium spatial transcriptomics |
| 揭示新型高糖基化人促红细胞生成素类似物：全面计算探索 |
Thahsin, N. |
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N/A |
Unveiling Novel Hyperglycosylated Analog of Human Erythropoietin: A Comprehensive Computational Exploration |
| 迈向更环保的AlphaFold2蛋白质复合物建模协议：来自CAPRI第55轮的见解 |
Savas, B. |
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N/A |
Towards a greener AlphaFold2 protocol for protein complex modeling: Insights from CAPRI Round 55 |
| R3DFEM：一个用于运行3D-CMCC-FEM模型的R包 |
Vangi, E. |
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R3DFEM: an R package for running the 3D-CMCC-FEM model |
| 定量分析Hsp100蛋白解聚酶在折叠蛋白底物上的进程性 |
Banwait, J. K. |
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Quantitative Insights into Processivity of an Hsp100 Protein Disaggregase on Folded Protein Substrates |
| 基于强化学习的加权集成方法的罕见事件采样 |
Yang, D. |
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N/A |
Rare-Event Sampling using a Reinforcement Learning-Based Weighted Ensemble Method |
| 与加速亨廷顿病进展相关的FAN1点突变改变了其在DNA上的PCNA介导的组装 |
Aretz, J. |
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A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA |
| 嗜酸性粒细胞主要碱性蛋白-1的原位晶体结构 |
Yang, J. E. |
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N/A |
In situ crystalline structure of the Eosinophil major basic protein-1 |
| 编织DNA的几何结构决定了超螺旋的分布 |
Hong, Y. |
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N/A |
Geometry of Braided DNA Dictates Supercoiling Partition |
| 无序蛋白质：微相还是关联聚合物？ |
Girard, M. |
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N/A |
Disordered proteins: microphases or associative polymers? |
| 通过深度学习和协同进化分析揭示的细胞质苹果酸脱氢酶的热适应性 |
Shukla, D. |
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N/A |
Thermal Adaptation of Cytosolic Malate Dehydrogenase Revealed by Deep Learning and Coevolutionary Analysis |
| 细胞穿透肽对膜破坏的计算研究 |
Catalina-Hernandez, E. |
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N/A |
Computational Insights into Membrane Disruption by Cell-Penetrating Peptides |
| 生物膜上的质子迁移：脂质相、温度及成分对质子传递过程及膜质子屏障的依赖性 |
Ramanthrikkovil Variyam, A. |
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N/A |
Proton migration on biological membranes: Lipid phase, temperature, and composition dependence of proton transfer processes and membrane proton barrier |
| 我们能否开发出理想的RNA力场？从UUCG RNA四核苷酸环及其他系统的模拟中获得的启示。 |
Mlynsky, V. |
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N/A |
Can We Ever Develop an Ideal RNA Force Field? Lessons Learned from Simulations of UUCG RNA Tetraloop and Other Systems. |
| 内在无序蛋白质的序列-集合-功能关系的广义设计 |
Krueger, R. |
PDF |
N/A |
Generalized design of sequence-ensemble-function relationships for intrinsically disordered proteins |
| 混合蛋白质溶液中的扩散与粘度 |
Wozniak, S. |
PDF |
N/A |
Diffusion and Viscosity in Mixed Protein Solutions |
| Afadin 介导了与协同结合和肌动蛋白丝曲率相关的 F-肌动蛋白上的钙粘蛋白-连环蛋白复合物的聚集。 |
Gong, R. |
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N/A |
Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature |
| 阿片受体揭示了一种明确的细胞内机制，即内体G蛋白的激活 |
Fisher, N. M. |
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N/A |
Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation |
| 通过植物RNA热敏开关控制异源蛋白合成 |
Lastovka, F. |
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N/A |
Controlling heterologous protein synthesis through a plant RNA ThermoSwitch |
| 杏仁核亚区体积及分配在青春期前儿童中的情况——与年龄、性别和体重指数的关联 |
Overholtzer, L. N. |
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N/A |
Amygdala Subregion Volumes and Apportionment in Preadolescents -- Associations with Age, Sex, and Body Mass Index |
| 与亚临床性淡漠相关的前额叶-运动回路 |
Derosiere, G. |
PDF |
N/A |
Fronto-motor circuits linked to subclinical apathy |
| LPS结合的胱天蛋白酶激活和募集结构域（CARDs）是二分体的脂质结合模块。 |
Cao, A. B. |
PDF |
N/A |
LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules |
| 抗体-Fab和-Fc特性促进结核分枝杆菌的限制。 |
Grace, P. S. |
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N/A |
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction. |
| 巨细胞病毒与脑萎缩在不同人群中免疫衰老轨迹的关系 |
Touil, H. |
PDF |
N/A |
Relation of CMV and brain atrophy to trajectories of immunosenescence in diverse populations |
| 铜绿假单胞菌中葡糖胺基磷脂酰甘油的生物合成 |
Khan, F. Z. |
PDF |
N/A |
Biosynthesis of glucosaminyl phosphatidylglycerol in Pseudomonas aeruginosa |
| 跨代效应改变了表型可塑性的适应性后果及其调控途径的遗传结构 |
Bogan, S. N. |
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N/A |
Transgenerational effects alter the fitness consequences and genetic architecture of phenotypic plasticity and its regulatory pathways |
| 良好的系统发育分析揭示了蝶形花科豆科植物多样化过程中龙骨瓣花的多次起源。 |
Cai, L. |
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N/A |
Well-resolved phylogeny reveals multiple origins of keel flowers during the diversification of papilionoid legumes |
| 完整的参考基因组和泛基因组扩展了使用短读长测序和阵列数据进行全基因组DNA甲基化分析的生物学相关信息 |
Dong, Z. |
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N/A |
Complete Reference Genome and Pangenome Expand Biologically Relevant Information for Genome-Wide DNA Methylation Analysis Using Short-Read Sequencing and Array Data |
| 染色体水平的高分辨率单倍型解析基因组组装为深入了解意大利黑麦草（Lolium multiflorum Lam.）的高度杂合基因组提供了见解。 |
Chen, Y. |
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N/A |
Chromosome-level haplotype-resolved genome assembly provides insights into the highly heterozygous genome of Italian ryegrass (Lolium multiflorum Lam.) |
| 评估一种高通量质谱方法，利用体积吸收微采样（VAMS）设备加速临床癌症队列中的生物标志物发现。 |
Lucas, N. |
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N/A |
Assessment of a high-throughput mass spectrometry method to accelerate biomarker discovery in clinical cancer cohorts using volumetric absorptive microsampling (VAMS) devices. |
| ProFit-1D用于在3T磁场下量化J差异编辑数据 |
Chan, K. L. |
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N/A |
ProFit-1D for quantifying J-difference edited data at 3T |
| 使用从头设计的激动剂调整胰岛素受体信号传导 |
Wang, X. |
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N/A |
Tuning Insulin Receptor Signaling Using De Novo Designed Agonists |
| 纳米抗体表位预测中的AI驱动方法：我们是否已经到达？ |
Eshak, F. |
PDF |
N/A |
AI driven approaches in Nanobody Epitope Prediction: Are We There Yet? |
| 构建：一种用于识别蛋白质三级结构中功能性或结构重要区域的算法工具 |
Chivot, L. |
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N/A |
CONSTRUCT: an algorithmic tool for identifying functional or structurally important regions in protein tertiary structure |
| LipiDetective - 一种用于在串联质谱中识别分子脂质种类的深度学习模型 |
Wuerf, V. |
PDF |
N/A |
LipiDetective - a deep learning model for the identification of molecular lipid species in tandem mass spectra |
| 可解释的多组学整合：基于UMAP嵌入和密度聚类的分析 |
Castellano-Escuder, P. |
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N/A |
Interpretable multi-omics integration with UMAP embeddings and density-based clustering |
| 阿波罗：一种综合性的基于主机的GPU加速模拟器，用于模拟病毒进化和感染动力学在人群、组织和细胞间的传播过程。 |
Perera, D. |
PDF |
N/A |
Apollo: A comprehensive GPU-powered within-host simulator for viral evolution and infection dynamics across population, tissue, and cell |
| 精氨酸甲基化与磷酸化协同作用，调控NADP+的合成 |
Zhu, Y. |
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N/A |
Arginine methylation coordinates with phosphorylation to regulate NADP+ synthesis |
| 基于RSPO4的靶向LGR4/5/6的喜树碱类似物偶联物在结直肠癌临床前模型中的抗肿瘤活性研究。 |
Toh, Y. |
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N/A |
Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer. |
| 体内双光子荧光寿命成像技术解析了玉米维管束鞘细胞的光合特性 |
Chen, Z. |
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N/A |
In vivo two-photon FLIM resolves photosynthetic properties of maize bundle sheath cells |
| 肌联蛋白H样蛋白条件性缺失对心脏功能的影响。 |
Burnham, H. V. |
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N/A |
The effects of conditional loss of myosin binding protein H-like on cardiac function. |
| 利用量子点纳米颗粒追踪活体内促性腺激素释放激素介导的运动：对精子释放途径的深入了解 |
Julien, A. R. |
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N/A |
Tracking gonadotropin-releasing hormone-mediated movement in-vivo using quantum dot nanoparticles: insights into pathways leading to sperm release |
| 成熟树干钻孔处理前后树液流速的空间变化 |
Umebayashi, T. |
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N/A |
Spatial variations in sap flow rates in mature tree stems before and after drilling treatment |
| 单细胞RNA测序数据在预测植物代谢途径基因中的应用 |
Ma, J. |
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N/A |
The utility of single-cell RNA sequencing data in predicting plant metabolic pathway genes |
| 植物抵抗丁香假单胞菌的抗性中，水分免疫优先于气孔免疫。 |
Kemppinen, J. |
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N/A |
Water immunity overrides stomatal immunity in plant resistance to Pseudomonas syringae |
| NPF4.1 将胚胎衍生的 GA4 导入胚乳，以促进种子萌发 |
Sirlin-Josserand, M. |
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N/A |
NPF4.1 imports embryo-derived GA4 to the endosperm to promote seed germination |
| 计算微生物组药理学分析阐明了阴道微生物及其代谢物的抗癌潜力 |
Lawore, D. C. |
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N/A |
Computational Microbiome Pharmacology Analysis Elucidates the Anti-Cancer Potential of Vaginal Microbes and Metabolites |
| 成人生命周期中成功视觉短时记忆的多个神经通路 |
Jansen, M. G. |
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N/A |
Multiple neural pathways to successful visual short-term memory across the adult lifespan |
| 在人类内侧前额叶皮层中，随着巩固过程的进行，一个抽象的关系图谱逐渐显现。 |
Baram, A. |
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N/A |
An abstract relational map emerges in the human medial prefrontal cortex with consolidation |
| 扩展数学框架以研究在存在小胶质细胞包绕情况下的神经元动力学 |
Garcia, N. |
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N/A |
Extending mathematical frameworks to investigate neuronal dynamics in the presence of microglial ensheathment |
| 多巴胺和皮质iPSC衍生的神经元在不同的帕金森病突变中表现出溶酶体和线粒体功能障碍的差异：这对蛋白质沉积与选择性细胞丢失的意义 |
Chedid, J. |
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N/A |
Dopamine and cortical iPSC-derived neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction: implications for protein deposition versus selective cell loss |
| 口服避孕药对大脑网络的影响：一项重复和扩展研究 |
Haase, G. |
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N/A |
Effects of oral contraceptive pills on brain networks: A replication and extension |
| 同位素编码化学成像识别淀粉样斑块年龄依赖性结构成熟、突触丧失及毒性增加 |
Wood, J. I. |
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N/A |
Isotope Encoded Chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity |
| 纵向多组学揭示了TSC2致病变异扰乱了从结节性硬化症复杂病变中衍生的人类皮层类器官的发育轨迹 |
Niu, W. |
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N/A |
Longitudinal multi-omics reveals pathogenic TSC2 variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex |
| 长期记忆从优先和非优先状态中提取的工作记忆效果 |
Born, F. |
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N/A |
Long-Term Effects of Working Memory Retrieval From Prioritized and Deprioritized States |
| T-scope V4：用于自由活动动物光遗传标记的微型显微镜 |
Wang, Y. |
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N/A |
T-scope V4: miniaturized microscope for optogenetic tagging in freely behaving animals |
| 在灵长类动物的初级视觉皮层（V1）中，外周表征的活动在奔跑过程中会显著地受到调节。 |
Rowley, D. P. |
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N/A |
Activity in the peripheral representation within primate V1 is substantially modulated during running |
| R21/Matrix-M疟疾疫苗诱导的抗体库、功能和结构 |
McDaniel, J. R. |
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N/A |
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine |
| IgG自身抗体在类天疱疮中直接诱导角质形成细胞中依赖于MyD88的促炎性反应，从而导致病理性炎症反应： |
Bao, L. |
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N/A |
IgG autoantibodies in bullous pemphigoid directly induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes: |
| 代谢组学分析揭示脂肪酸在慢性病毒感染期间作为调节干细胞样耗竭CD8 T细胞的潜力 |
Kazane, K. R. |
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N/A |
Metabolomic Profiling Reveals Potential of Fatty Acids as Regulators of Stem-like Exhausted CD8 T Cells During Chronic Viral Infection |
| 研究儿童大脑和生物发育及其与身体、心理和学业成果的关系 |
Chang, H. |
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N/A |
Investigating Brain and Biological Development in Children and Their Relationship with Physical, Mental, and Academic Outcomes |
| 降水变化驱动草原功能群间相互作用及短期瞬时不稳定性的差异：一种基于阶段结构群落的方法 |
Gupta, A. |
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N/A |
Variation in precipitation drives differences in interactions and short-term transient instability between grassland functional groups: a stage-structured community approach |
| 冰川后遗传遗产、人口统计学与气候变化：为银冷杉制定保护优先事项 |
Balao, F. |
PDF |
N/A |
Postglacial Genetic Legacies, Demography, and Climate Change: Setting Conservation Priorities for Silver Fir |
| 软组织体积对骨骼气腔化程度估计的影响：对古鸟类动物的启示 |
Burton, M. G. |
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N/A |
The influence of soft tissue volume on estimates of skeletal pneumaticity: implications for fossil archosaurs |
| TP53 微基因分析的 161 个序列变化提供了空间约束和调控元件对变异诱导剪接影响的证据。 |
Canson, D. M. |
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N/A |
TP53 minigene analysis of 161 sequence changes provides evidence for role of spatial constraint and regulatory elements on variant-induced splicing impact |
| 吞噬作用中的蛋白激酶：癌症的潜在遗传生物标志物 |
Arumilli, S. |
PDF |
N/A |
Protein Kinases in Phagocytosis: Promising Genetic Biomarkers for Cancer |
| 基于组织异质性的对比增强光学相干弹性成像在乳腺癌可视化中的应用 |
Li, J. |
PDF |
N/A |
Visualization of breast cancer using contrast-enhanced optical coherence elastography based on tissue heterogeneity |
| 基准测试用于抗体设计的生成模型 |
Ucar, T. |
PDF |
N/A |
Benchmarking Generative Models for Antibody Design |
| InteracTor：一种新的综合特征提取工具包，用于改进蛋白质结构性质的表征 |
Silva, J. C. F. |
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N/A |
InteracTor: A new integrative feature extraction toolkit for improved characterization of protein structural properties |
| 鉴定葡萄膜黑色素瘤中可靶向的表观遗传脆弱性 |
Yenisehirli, G. |
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N/A |
Identification of targetable epigenetic vulnerabilities in uveal melanoma |
| 解决深度学习中的领域偏移问题：从植物病害诊断和花卉识别中获得的挑战与见解 |
Sun, J. |
PDF |
N/A |
Addressing domain shift in deep learning: Challenges and insights from plant disease diagnosis and flower recognition |
| 基于随机化的不同拓扑和癌症表达特征的相互作用基因对的评估 |
Dalgic, E. |
PDF |
N/A |
Randomization based evaluation of distinct topological and cancer expression characteristics of mutually acting gene pairs |
| 使用多传感器地理定位器和稳定同位素揭示的高纬度繁殖鸣禽（Setophaga coronata coronata）的迁徙策略 |
Szarmach, S. J. |
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N/A |
Migration strategies of a high-latitude breeding songbird (Setophaga coronata coronata) revealed using multi-sensor geolocators and stable isotopes |
| 研究合生干预对健康年轻女性工作记忆表现的影响 |
Salimi, Y. |
PDF |
N/A |
Investigating the Effects of Synbiotic Intervention on Working Memory performance in Healthy Young Women |
| ORCO：Ollivier-Ricci曲率-组学：一种用于分析生物系统鲁棒性的无监督方法 |
Simhal, A. K. |
PDF |
N/A |
ORCO: Ollivier-Ricci Curvature-Omics: an unsupervised method for analyzing robustness in biological systems |
| 基于pA-Tn5插入模式的TIP-seq峰值调用参数的合理设计提高了预测能力 |
Roberts, T. |
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N/A |
Rational design of peak calling parameters for TIP-seq based on pA-Tn5 insertion patterns improves predictive power |
| 全基因组CRISPR/Cas9筛选揭示影响肿瘤细胞对NK细胞介导杀伤敏感性的因素 |
Guia, S. |
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N/A |
Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killing |
| 头孢吡肟-他尼巴坦和头孢布坦-莱达巴坦对导致头孢他啶-阿维巴坦耐药的KPC变异株保持活性 |
Myers, C. L. |
PDF |
N/A |
Cefepime-Taniborbactam and Ceftibuten-Ledaborbactam Maintain Activity Against KPC Variants that Lead to Ceftazidime-Avibactam Resistance |
| MEDOC：一种快速、可扩展且在数学上精确的算法，用于在大规模无序蛋白质中进行位点特异性的质子化程度预测 |
Fossat, M. J. |
PDF |
N/A |
MEDOC: A fast, scalable and mathematically exact algorithm for the site-specific prediction of the protonation degree in large disordered proteins |
| 对SARS-CoV-2核衣壳C端结构域RNA结合抑制剂的结构见解 |
Dhaka, P. |
PDF |
N/A |
Structural insights into the RNA binding inhibitors of the C-terminal domain of the SARS-CoV-2 nucleocapsid |
| 柴-1：解码生命的分子相互作用 |
Chai Discovery (Chai), |
PDF |
N/A |
Chai-1: Decoding the molecular interactions of life |
| 小锚蛋白重复蛋白对SARS-CoV-2变种的功能活性与结合特异性 |
Park, Y.-J. |
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N/A |
Functional Activity and Binding Specificity of small Ankyron Repeat Proteins against SARS-CoV-2 variants |
| 人类扁桃体类器官揭示了调节ChAdOx1体液和细胞反应的先天通路 |
Pudjohartono, M. F. |
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N/A |
Human tonsil organoids reveal innate pathways modulating humoral and cellular responses to ChAdOx1 |
| 北极洋病毒群落：季节性、两极性及原核生物相互作用 |
Calayag, A. |
PDF |
N/A |
Arctic Ocean virus communities: seasonality, bipolarity, and prokaryotic interactions |
| 弧菌可能是欧洲沿海环境中新型粘菌素抗性基因的潜在来源 |
Saad, J. |
PDF |
N/A |
Vibrio are a potential source of novel colistin-resistance genes in European coastal environments |
| 登革病毒2型感染内皮细胞条件培养基对上皮细胞愈合的影响：活细胞成像分析 |
Hincapie, V. |
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N/A |
Effect of inactivated conditioned media from DENV-2-infected endothelial cells on epithelial cell healing: live cell imaging analysis. |
| 代谢重编程通过稳定干扰素-γ诱导的IRF1来影响痘病毒感染的结果 |
Chang, T. |
PDF |
N/A |
Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-g induced IRF1 |
| 元基因组覆盖率的差异可能会混淆基于丰度和多样性的结论。 |
Riquelme, B. A. |
PDF |
N/A |
Differences in metagenome coverage may confound abundance-based and diversity conclusions |
| 鼻内递送一种广泛中和的单域抗体，靶向ACE2，可预防SARS-CoV-2感染。 |
Blachier, S. |
PDF |
N/A |
Intranasal delivery of a broadly neutralizing single domain antibody targeting ACE2 protects against SARS-CoV-2 infection |
| 新型转基因人源化α-1抗胰蛋白酶缺乏症小鼠模型，基于小鼠SERPINA1基因敲除背景 |
Oshins, R. |
PDF |
N/A |
Novel Transgenic Humanized Alpha-1 Antitrypsin Deficiency Mouse Model on Murine SERPINA1 Null Background |
| 从Haloferax volcanii中删除前病毒会影响运动性、抗逆性和CRISPR RNA的表达。 |
Di Cianni, N. |
PDF |
N/A |
Provirus deletion from Haloferax volcanii affects motility, stress resistance and CRISPR RNA expression |
| RPS19 和 RPL5，钻石黑人贫血症中最常见的突变基因，影响DNA双链断裂修复。 |
DeCleene, N. F. |
PDF |
N/A |
RPS19 and RPL5, the most commonly mutated genes in Diamond Blackfan anemia, impact DNA double-strand break repair |
| 鉴定单性生殖和雌雄同体海洋鱼类中性二型循环微小RNA。 |
Geffroy, B. |
PDF |
N/A |
Identifying sexually dimorphic circulating microRNAs in gonochoristic and hermaphroditic marine fish species. |
| RAD51同源物与RAD51同源物复合物BCDX2和CX3与BRCA2相互作用 |
Thrasher, J. G. |
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N/A |
RAD51 Paralogs and RAD51 Paralog Complexes BCDX2 and CX3 Interact with BRCA2 |
| SMYD5是一种核糖体甲基转移酶，通过识别KXY基序，对RPL40赖氨酸22进行三甲基化修饰。 |
Hamey, J. J. |
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N/A |
SMYD5 is a ribosomal methyltransferase which trimethylates RPL40 lysine 22 through recognition of a KXY motif |
| 果蝇（Drosophila melanogaster）中对异硫氰酸酯敏感的气味受体及其在食草性近缘物种中的进化扩张 |
Matsunaga, T. |
PDF |
N/A |
Odorant receptors tuned to isothiocyanates in Drosophila melanogaster and their evolutionary expansion in herbivorous relatives |
| 一组针对果蝇中保守信号配体的分裂Gal4驱动器 |
Ewen-Campen, B. |
PDF |
N/A |
A collection of split-Gal4 drivers targeting conserved signaling ligands in Drosophila |
| 斑马鱼中rbfox1功能丧失导致bdnf/trkb2和pac1a表达失调，进而引起HPI轴过度激活、应激反应改变以及稳态负荷过重。 |
Leggieri, A. |
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N/A |
rbfox1 loss of function in zebrafish leads to dysregulation in bdnf/trkb2 and pac1a expression resulting in HPI axis hyperactivation, altered stress response and allostatic overload |
| CREB3功能获得性变异可预防ALS |
Megat, S. |
PDF |
N/A |
CREB3 gain of function variants protect against ALS |
| 在“狗衰老项目”中，来自多样化犬群的DNA甲基化模式揭示了年龄差异。 |
Mariner, B. L. |
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N/A |
DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project |
| 近北极地区的蝙蝠（Myotis bats）具有广泛的寿命和由DNA病毒驱动的适应性。 |
Vazquez, J. M. |
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N/A |
Extensive longevity and DNA virus-driven adaptation in nearctic Myotis bats |
| 磷酸蛋白质组学揭示了成纤维细胞在炎症刺激下复杂的资源管理机制 |
Janker-Bortel, P. |
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N/A |
Phosphoproteomics highlights complex resource management upon inflammatory stimulation of fibroblasts |
| 扭转性创伤性视神经病变（TITON）：一种生理上相关的创伤性视神经病变动物模型 |
Ryan, A. K. |
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N/A |
Torsion-Induced Traumatic Optic Neuropathy (TITON): A Physiologically Relevant Animal Model of Traumatic Optic Neuropathy |
| 通过功能引导的计算机模拟进化将AAV衣壳序列映射到功能 |
Zheng, H. |
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N/A |
Mapping AAV capsid sequences to functions through function-guided in silico evolution |
| 深度学习助力在Pharos中发现激酶药物靶点 |
Halasz, A. M. |
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N/A |
Deep Learning enabled discovery of kinase drug targets in Pharos |
| 探索Corallococcus属的代谢潜力：丰富的次生代谢产物和CAZymes来源 |
Hossain, M. S. |
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N/A |
Exploration of the Metabolic Potential of the Corallococcus Genus: A Rich Source of Secondary Metabolites, and CAZymes |
| GATA1缺陷型人类多能干细胞生成的嗜中性粒细胞具有增强的抗真菌免疫能力，这种免疫能力是通过整合素CD18介导的。 |
Wagner, A. S. |
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N/A |
GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18 |
| 在低pH、低温及高渗透压应激条件下，大肠杆菌的生长需要wzxE翻转酶来处理肠杆菌共同抗原中间体。 |
Yamaguchi, S. |
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N/A |
Escherichia coli growth under low pH, low temperature, and high osmotic stress conditions requires the wzxE flippase for the enterobacterial common antigen intermediate |
| 系统性、高通量地表征噬菌体基因在不同宿主中的必需性 |
Chen, J. |
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N/A |
Systematic, high-throughput characterization of bacteriophage gene essentiality on diverse hosts |
| 火疫病菌欧文氏菌通过苹果叶自然脱落的毛状体伤口进入叶片。 |
Millett, F. |
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N/A |
The fire blight pathogen Erwinia amylovora enters apple leaves through naturally-occurring wounds from the abscission of trichomes |
| 多聚腺苷酸化酶PAPI是致病菌中维持毒力质粒所必需的 |
Schubert, K. |
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N/A |
The polyadenylase PAPI is required for virulence plasmid maintenance in pathogenic bacteria |
| 一种用于倾斜系列数据相干功率谱平均以改进CTF估计的方法 |
Khavnekar, S. |
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N/A |
An approach for coherent periodogram averaging of tilt-series data for improved CTF estimation |
| 质粒DNA中的人源Fos启动子活性过高 |
Gorbunov, A. |
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N/A |
Isolated human Fos promoter in plasmid DNA is overactive |