| 杂合优势可以解释免疫基因的非凡多样性。 |
Siljestam, M. |
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N/A |
Heterozygote advantage can explain the extraordinary diversity of immune genes |
| 细菌中对多种药物产生耐药性的快速进化，且不依赖于SOS系统 |
Zhang, L. |
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N/A |
Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria |
| 网络的自然史：在地理历史数据中建模高阶相互作用 |
Rojas, A. |
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N/A |
A natural history of networks: Modeling higher-order interactions in geohistorical data |
| 多组学方法揭示RNA动态促进细胞对DNA低甲基化的敏感性 |
Ge, A. Y. |
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N/A |
A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation |
| 同时可视化单细胞RNA测序研究中的细胞及其标记基因 |
Bhattacharya, N. |
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N/A |
Simultaneous visualization of cells and marker genes from scRNA-seq studies |
| BIBSNet：一种用于MRI扫描的深度学习婴儿图像脑部分割网络 |
Hendrickson, T. J. |
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N/A |
BIBSNet: A Deep Learning Baby Image Brain Segmentation Network for MRI Scans |
| 目标检测调节成功记忆编码的脑电图频谱相关性 |
Broitman, A. W. |
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N/A |
Target Detection Modulates EEG Spectral Correlates of Successful Memory Encoding |
| 基于血液的纳米定量免疫复合物检测：在诊断为帕金森病的患者中，对抑制剂耐药的种子活性检测 |
Christenson, P. R. |
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N/A |
Blood-based Nano-QuIC: Inhibitor-resistant Detection of Seeding Activity in Patients Diagnosed with Parkinson Disease |
| 逆转录转座子和卫星DNA的周转驱动了果蝇在短期进化时间尺度上的着丝粒重构 |
Courret, C. |
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N/A |
Turnover of retroelements and satellite DNA drives centromere reorganizationover short evolutionary timescales in Drosophila |
| 桥粒突变影响肿瘤微环境以促进黑色素瘤增殖 |
Baron, M. |
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N/A |
Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation |
| LMD: 单细胞RNA-seq数据中独立于集群的多尺度标记识别 |
Li, R. |
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N/A |
LMD: Cluster-Independent Multiscale Marker Identification in Single-cell RNA-seq Data |
| 一个用于非平衡自组装和分枝肌动蛋白网络中力形态权衡的热力学框架 |
Rennert, E. |
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N/A |
A thermodynamic framework for nonequilibrium self-assembly and force morphology tradeoffs in branched actin networks |
| 算法代理中的结构化动态 |
Ruffini, G. |
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N/A |
Structured dynamics in the algorithmic agent |
| 视觉皮层中细胞类型与视觉依赖性转录程序相互作用的时空分析 |
Xie, F. |
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N/A |
Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex |
| 最小顶点模型解释了果蝇背部闭合过程中羊膜细胞如何避免液化。 |
Tah, I. |
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N/A |
Minimal vertex model explains how the amnioserosa avoids fluidization during Drosophila dorsal closure |
| U/V性染色体系统中性分化的发育途径 |
Liesner, D. |
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N/A |
Developmental pathways underlying sexual differentiation in a U/V sex chromosome system |
| 神经代码追踪叙事中的先前事件，并预测后续对细节的记忆。 |
Collin, S. H. P. |
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N/A |
Neural codes track prior events in a narrative and predict subsequent memory for details |
| 基于模型的前臂肌肉在2自由度手腕任务中使用MRE估计主动和被动肌肉力的方法 |
Helm, C. A. |
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N/A |
Model-Based Estimation of Active and Passive Muscle Forces Using MRE in Forearm Muscles During 2-DOF Wrist Tasks |
| 查尔酮和吡唑啉衍生物的合成及其作为ELF3-MED23相互作用新型抑制剂的生物学评估 |
Hwang, S.-Y. |
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N/A |
Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as novel inhibitor for ELF3-MED23 Interaction |
| 多重检测人类疾病相关突变揭示了UTR二核苷酸组成作为RNA稳定性的主要决定因素 |
Su, J.-Y. |
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N/A |
Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability |
| 基于压缩感知的方法识别驱动习得病原体回避的模块化神经回路 |
Hallacy, T. |
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N/A |
Compressed sensing based approach identifies modular neural circuitry driving learned pathogen avoidance |
| 在77K下测量的叶片中从PSII到PSI的激发溢出 |
Terashima, I. |
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N/A |
Excitation Spillover from PSII to PSI Measured in Leaves at 77K |
| 依赖于小泛素样修饰物（SON）的核斑点再生能够缓解蛋白质病 |
Dion, W. |
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N/A |
SON-dependent nuclear speckle rejuvenation alleviates proteinopathies |
| 年轻小鼠的微生物群通过调节老年小鼠的丁酸水平，对抗了与年龄相关的痛风易感性。 |
Song, N. |
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N/A |
Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice |
| 高加索侏儒鰕虎鱼（Knipowitschia cf. caucasica）染色体水平基因组参考，这是一种新入侵莱茵河的鰕虎鱼科外来物种 |
Schoenle, A. |
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N/A |
Chromosome level genome reference of the Caucasian dwarf goby Knipowitschia cf. caucasica, a new alien Gobiidae invadingthe River Rhine |
| 改变沙眼衣原体的氧化还原状态会直接影响其发育周期的进展。 |
Singh, V. |
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N/A |
Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression |
| 对鼠伤寒沙门氏菌基因组抗菌药物耐药性流行病学的剖析 |
Kaur, S. |
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N/A |
A dissection of the genomic antimicrobial resistance epidemiology of Salmonella Typhimurium |
| NHR-23调控的假定蛋白酶抑制剂mlt-11基因对于秀丽隐杆线虫（C. elegans）的表皮结构和功能是必需的。 |
Ragle, J. M. |
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N/A |
The NHR-23-regulated putative protease inhibitor mlt-11 gene is necessary for C. elegans cuticle structure and function |
| 利用Sentence-BERT从预测数据库中精炼疾病相关蛋白质水平的微RNA靶点相互作用 |
Chen, B. |
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N/A |
Refining Protein-Level MicroRNA Target Interactions in Disease from Prediction Databases Using Sentence-BERT |
| PVD神经元在秀丽隐杆线虫中具有雄性特异性结构和交配功能。 |
Iosilevskii, Y. |
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N/A |
The PVD neuron has male-specific structure and mating function in C. elegans |
| HIV-1感染与生发中心B细胞的耗竭以及胃肠道中IgA+浆细胞的减少有关。 |
Cossarini, F. |
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N/A |
HIV-1 infection is associated with depletion of germinal center B cells and a decrease in IgA+ plasma cells in the GI tract |
| 环二腺苷酸推动沙眼衣原体发育周期的进展 |
Lee, J. |
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N/A |
Cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis |
| 多物理场模拟揭示了患者来源的左心房组织力学中与纤维化相关的变化对血流动力学的影响 |
Gonzalo, A. |
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N/A |
Multi-physics simulations reveal hemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics |
| 累积的储备阻碍了与年龄相关的噪音中言语感知中的神经补偿 |
Zhang, L. |
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N/A |
Accumulated reserves hold back age-related neural compensation in speech-in-noise perception |
| ProtEx：一种用于蛋白质功能预测的检索增强方法 |
Shaw, P. |
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N/A |
ProtEx: A Retrieval-Augmented Approach for Protein Function Prediction |
| 使用语言模型进行蛋白质序列域注释 |
Sarkar, A. |
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N/A |
Protein Sequence Domain Annotation using Language Models |
| Gap-App：一种基于性别的AI胰腺导管腺癌生存预测器，作为面向患者和医生的网络应用程序开放 |
Ojha, A. |
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N/A |
Gap-App: A sex-distinct AI-based predictor for pancreatic ductal adenocarcinoma survival as a web application open to patients and physicians |
| 使用键合图对单个肌动蛋白丝聚合进行基于能量的建模 |
Gawthrop, P. |
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N/A |
Energy-based Modelling of Single Actin Filament Polymerisation Using Bond Graphs |
| 黑色素化与土壤矿物和微生物特性相互作用，共同决定土壤中真菌碳和氮的持久性。 |
Beidler, K. V. |
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N/A |
Melanization interacts with soil mineral and microbial properties to determine fungal carbon and nitrogen persistence in soils |
| 分层种群遗传结构和适应性特征在尖吻鲈（Lates calcarifer）中的体现 |
Campbell, M. A. |
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N/A |
Hierarchical population genetic structure and signatures of adaptation in Lates calcarifer |
| 翼龙尾巴羽片的新软组织数据显示了其复杂、动态的张力使用方式，并扩展了其进化起源。 |
Jagielska, N. |
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N/A |
New soft tissue data of pterosaur tail vane reveals sophisticated, dynamic tensioning usage and expands its evolutionary origins |
| I2Bot：一种用于昆虫导航的多模态和具身模拟的开源工具 |
Sun, X. |
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N/A |
I2Bot: an open-source tool for multi-modal and embodied simulation of insect navigation |
| 基于石墨烯的微电极，具有增强的界面和可调的孔隙结构，用于提高神经记录效果 |
Dong, M. |
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N/A |
Graphene-based micro-electrodes with reinforced interfaces and tunable porous structures for improved neural recordings |
| Xist RNA结合特定的常染色体基因，并依赖于重复序列B来调控这些基因的表达。 |
Yao, S. |
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N/A |
Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression |
| 硫醚功能化纤维素用于制备氧化响应性生物材料涂层和薄膜 |
DuBois, E. M. |
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N/A |
Thioether-functionalized cellulose for the fabrication of oxidation-responsive biomaterial coatings and films |
| 爱荷华脑行为建模工具包：一个用于成像-行为和损伤-缺陷关系推断与预测建模的开源MATLAB工具 |
Griffis, J. C. |
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N/A |
Iowa Brain-Behavior Modeling Toolkit: An Open-Source MATLAB Tool for Inferential and Predictive Modeling of Imaging-Behavior and Lesion-Deficit Relationships |
| 一类新的受体：脂质通过其膜锚定物调节哺乳动物Gsα刺激的腺苷酸环化酶活性 |
Landau, M. |
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N/A |
A new class of receptors: Lipids regulate mammalian Gsα-stimulated adenylyl cyclase activities via their membrane anchors |
| 百日咳博德特氏菌疫苗反应中的Th1极化通过正反馈回路得以维持。 |
Willemsen, L. |
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N/A |
Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop |
| 不同表型水稻干旱和盐胁迫公共RNA测序数据的Meta分析 |
Shintani, M. |
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N/A |
Meta-analysis of public RNA-sequencing Data of Drought and Salt Stresses in Different Phenotypes of Oryza sativa |
| 使用扩散模型生成P型ATP酶的多状态构象 |
Xu, J. |
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N/A |
Generating Multi-state Conformations of P-type ATPases with a Diffusion Model |
| 生物分子凝聚体在相分离的质量守恒反应扩散系统实验与理论之间架起了桥梁。 |
Li, C. |
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N/A |
Biomolecular condensates bridge experiment and theory of mass-conserving reaction-diffusion systems in phase separation |
| 领地性和资源可用性调节同种个体相遇对哺乳动物捕食者觅食行为的影响 |
Clermont, J. |
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N/A |
Territoriality and resource availability modulate the effect of conspecific encounters on the foraging behaviours of a mammalian predator |
| VP35中隐秘口袋的打开和关闭使其在两种不同的RNA结合模式之间切换。 |
Mallimadugula, U. L. |
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N/A |
Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes |
| 开发日本柳杉D. Don中雄性不育4 (MS4)基因的简易DNA提取和PCR-RFLP方法：迈向环境友好型协议 |
Ueno, S. |
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N/A |
Developing simple DNA extraction and PCR-RFLP for MALE STERILITY 4 (MS4) gene in Cryptomeria japonica D. Don: Toward an environmentally friendly protocol |
| RNA在α-突触核蛋白相分离的纳米尺度组织中的作用 |
Zappone, S. |
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N/A |
The role of RNA in the nanoscale organization of alpha-synuclein phase separation |
| 多发性硬化症中克隆扩增的CD8+ T细胞的抗原特异性 |
Mittl, K. |
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N/A |
Antigen-specificity of clonally-enriched CD8+ T cells in multiple sclerosis |
| 通过双向循环门控建模大脑中的注意力和绑定机制 |
Salehinajafabadi, S. |
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N/A |
Modeling Attention and Binding in the Brain through Bidirectional Recurrent Gating |
| 致癌驱动突变N642H在STAT5B SH2结构域中的结构影响 |
Haas-Neill, L. |
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N/A |
The structural influence of the oncogenic driver mutation N642H in the STAT5B SH2 domain |
| 基于角色共享的协同群体行为分析：从实验任务到3对3篮球比赛的实际应用作为试点研究 |
Ichikawa, J. |
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N/A |
Analysis of coordinated group behavior based on role-sharing: Practical application from an experimental task to a 3-on-3 basketball game as a pilot study |
| 在小鼠齿状回中，5-HT7受体的激活并不影响穿通路径突触处的θ波爆发诱导的可塑性。 |
Siwiec, M. |
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N/A |
Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse |
| 在小鼠齿状回中，5-HT7受体的激活并不影响穿通路径突触处的theta波簇诱导的可塑性。 |
Siwiec, M. |
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N/A |
Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse |
| 模仿机制：肉类与肉类替代品的比较 |
St. Pierre, S. R. |
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N/A |
Mimicking mechanics: A comparison of meat and meat analogs |
| 外膜变化使细菌能够逃避捕食 |
Mridha, S. |
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N/A |
Outer membrane changes enable evolutionary escape from bacterial predation |
| stFormer：一种用于空间转录组学的基石模型 |
Cao, S. |
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N/A |
stFormer: a foundation model for spatial transcriptomics |
| 细菌的运动模式能够顺利适应空间限制和紊乱的变化 |
Zhang, H. |
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N/A |
Bacterial motility patterns adapt smoothly in response to spatial confinement and disorder |
| 神经运动生成的空间和网络原理 |
Komi, S. |
PDF |
N/A |
Spatial and network principles behind neural generation of locomotion |
| James-Stein估计器提高了人体运动学和代谢数据中的准确性和样本效率。 |
Alwan, A. |
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N/A |
James-Stein estimator improves accuracy and sample efficiency in human kinematic and metabolic data |
| 一种非典型的E3连接酶在营养应激期间保护核糖体 |
Douglas, T. |
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N/A |
An atypical E3 ligase safeguards the ribosome during nutrient stress |
| 计算微生物组药理学分析阐明阴道微生物及其代谢物的抗癌潜力 |
Lawore, D. C. |
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N/A |
Computational Microbiome Pharmacology Analysis Elucidates the Anti-Cancer Potential of Vaginal Microbes and Metabolites |
| 腹侧纹状体与凸显网络具有特别密切的关联，该网络包括背外侧前额叶皮层中的区域。 |
Kosakowski, H. L. |
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N/A |
Ventral Striatum is Preferentially Correlated with the Salience Network Including Regions in Dorsolateral Prefrontal Cortex |
| 从生物物理模型和保存的标本中可靠地重建蟋蟀鸣声 |
Weiner, R. J. |
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N/A |
Reliable reconstruction of cricket song from biophysical models and preserved specimens |
| 多成分营养补充剂与衰老干预在老年小鼠中具有可比的抗衰老功效 |
Brookes, C. |
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N/A |
Comparable anti-ageing efficacies of a multi-ingredient nutraceutical and a senolytic intervention in old mice |
| 两种亚麻品种的比较分析表明，木脂素介导的盐胁迫适应性 |
Debnath, A. J. |
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N/A |
A comparative analysis between two flax varieties indicates lignan-mediated salt stress adaptiveness |
| 用于酶学表征菱形蛋白酶RHBDL4的体外平台 |
Bhaduri, S. E. |
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N/A |
An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4 |
| 半监督组学因子分析（SOFA）在多组学数据中将已知的变异源与潜在因子解耦。 |
Capraz, T. |
PDF |
N/A |
Semi-supervised Omics Factor Analysis (SOFA) disentangles known sources of variation from latent factors in multi-omics data |
| 用于预测血脑屏障渗透性的注意力图神经网络模型 |
Collins, J. W. |
PDF |
N/A |
Attentive graph neural network models for the prediction of blood-brain barrier permeability |
| 用于预测血脑屏障渗透性的注意力图神经网络模型 |
Collins, J. W. |
PDF |
N/A |
Attentive graph neural network models for the prediction of blood-brain barrier permeability |
| Asgard古菌对真核生物起源的显著贡献 |
Tobiasson, V. |
PDF |
N/A |
Dominant contribution of Asgard archaea to eukaryogenesis |
| 通过整合多层次事件时间概率分布进行时间预测 |
Huang, Y. T. |
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N/A |
Temporal Prediction through Integration of Probability Distributions of Event Timings at Multiple Levels |
| 多巴胺在执行动作序列期间奖励预期和可预测性中的作用 |
Magnard, R. |
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N/A |
Role of dopamine in reward expectation and predictability during execution of action sequences |
| 理解神经元多样性：输入动力学和选择性的作用 |
Joshi, N. |
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N/A |
Understanding Neuronal Diversity: Role of Input Dynamics and Selectivity |
| 在高级皮质网络中，阿尔法和贝塔节律中的时间延迟表征随着关系整合需求的增加而追踪。 |
Robinson, C. N. |
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N/A |
Temporally delayed representations in alpha and beta rhythms in higher-order cortical networks track increasing relational integration demands |
| 海马体中刺激意义的表征 |
Biane, J. S. |
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N/A |
Representations of stimulus meaning in the hippocampus |
| 活性氧物种的增加是新生儿小脑修复的基础 |
Pakula, A. |
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N/A |
An increase in reactive oxygen species underlies neonatal cerebellum repair |
| 准确而灵活的有效群体数量历史估计 |
Huang, Z. |
PDF |
N/A |
Accurate and flexible estimation of effective population size history |
| SPLENDID 在生物银行规模的数据中整合了连续的遗传祖先信息，以提高不同人群的多基因风险预测能力。 |
Chen, T. |
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N/A |
SPLENDID incorporates continuous genetic ancestry in biobank-scale data to improve polygenic risk prediction across diverse populations |
| KLHDC7B是一种与人类年龄相关性听力损失相关的新基因，对于维持小鼠的听力是必需的。 |
Kaufman, A. M. |
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N/A |
KLHDC7B, a novel gene associated with age-related hearing loss in humans, is required for the maintenance of hearing in mice. |
| 通过靶向3D基因组，利用蒽环类药物实现化疗效果 |
Tan, M. |
PDF |
N/A |
Targeting the 3D genome by anthracyclines for chemotherapeutic effects |
| 小脑在认知老化中的保护作用 |
d'Oleire Uquillas, F. |
PDF |
N/A |
A protective role for the cerebellum in cognitive aging |
| 前额叶协调：一种用于啮齿动物运动抑制的皮层网络 |
Jaeckel, Z. |
PDF |
N/A |
Prefrontal orchestration: a cortical network for rodent motor inhibition |
| 神经元的限制性N-糖基化在分化过程中被编程 |
Kiwimagi, K. |
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N/A |
The restricted N-glycome of neurons is programmed during differentiation |
| 综合应激反应通过维持线粒体输入效率来抑制依赖于PINK1的线粒体自噬 |
Yang, M. |
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N/A |
The Integrated Stress Response Suppresses PINK1-dependent Mitophagy by Preserving Mitochondrial Import Efficiency |
| 利用稳定同位素示踪法建模复合脂质稳态 |
Wessendorf-Rodriguez, K. |
PDF |
N/A |
Modeling Compound Lipid Homeostasis Using Stable Isotope Tracing |
| GRASP55调控溶酶体酶β-氨基己糖苷酶A的分选与成熟 |
Akaaboune, S. R. |
PDF |
N/A |
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A |
| 袖内运输同时利用了微管和肌动蛋白轨道。 |
Judernatz, J. |
PDF |
N/A |
Intra-manchette transport employs both microtubule and actin tracks |
| BAK驱动的凋亡孔形成的脂质特征 |
Uren, R. T. |
PDF |
N/A |
A lipid signature of BAK-driven apoptotic pore formation |
| 全面鉴定质膜修复蛋白揭示了细胞对质膜损伤的时空响应 |
Yamazaki, Y. |
PDF |
N/A |
Comprehensive identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma membrane damage |
| β-肾上腺素能阻滞剂通过胰腺β细胞中的PKA/RYR2/TRPM5途径增加cAMP并刺激胰岛素分泌（体外实验） |
Murao, N. |
PDF |
N/A |
β-adrenergic blockers increase cAMP and stimulate insulin secretion through a PKA/RYR2/TRPM5 pathway in pancreatic β-cells in vitro |
| I类PAK在调节肌动蛋白细胞骨架兴奋性中的作用。 |
Tyler, J. J. |
PDF |
N/A |
A role for class I PAKs in the regulation of the excitability of the actin cytoskeleton. |
| 新型抗体可检测原生生物病原体、细胞黏菌和植物中的核内质O-岩藻糖 |
Tiwari, M. |
PDF |
N/A |
Novel antibodies detect nucleocytoplasmic O-fucose in protist pathogens, cellular slime molds, and plants |
| 自闭症中的白质微结构改变通过束分析定位 |
Kim, G. S. |
PDF |
N/A |
White Matter Microstructural Alterations in Autism Localized with Bundle Analytics |
| 对一种脆海星中荧光素酶的功能表征表明，平行进化受到卤代烷脱卤酶基因组可用性的影响。 |
Lau, E. S. |
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N/A |
Functional characterization of luciferase in a brittle star indicates parallel evolution influenced by genomic availability of haloalkane dehalogenase |
| 光照在弱电鱼的活动感知和控制中起到中介作用，促使两者发生转变。 |
Yeh, H. |
PDF |
N/A |
Illumination mediates a switch in both active sensing and control in weakly electric fish |
| 在“通过网络推断和计算机模拟基因扰动剖析细胞身份”中发现的重大问题 |
Nourisa, J. |
PDF |
N/A |
Critical issues found in "Dissecting cell identity via network inference and in silico gene perturbation" |
| 淡水螺类Physa acuta中，同代与跨代捕食者诱导可塑性的转录组基础 |
Dejeux, L. |
PDF |
N/A |
Transcriptomic bases of within- and trans-generational predator-induced plasticity in the freshwater snail Physa acuta |
| 集成机器学习在代谢组数据中的应用：识别与巨噬细胞极化相关的代谢物 |
Gannavaram, A. |
PDF |
N/A |
Application of Ensemble Machine Learning to Metabolomic Data Identifies Metabolites Associated with Macrophage Polarization |
| 囊杆菌素脱靶分析揭示了其在真核生物中具有良好的安全性、超氧化物还原能力以及SCARB1抑制作用 |
Risch, T. |
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N/A |
Cystobactamid off-target profiling reveals favorable safety, superoxide reduction, and SCARB1 inhibition in eukaryotes |
| 三种细胞色素P450酶在鼠尾草属植物中催化形成呋喃克罗烷前体。 |
Lin, R. |
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N/A |
Three cytochrome P450 enzymes catalyse the formation of furanoclerodane precursors in Salvia spp. |
| 对来自芬兰的首个巨型病毒Jyväskylä病毒的基因组和结构深入研究 |
de Freitas Almeida, G. M. |
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N/A |
Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland |
| 高糖食物会加剧抗生素引起的微生物群损伤。 |
Dai, A. |
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N/A |
Sugar-rich foods exacerbate antibiotic-induced microbiome injury |
| 丝裂霉素C在金黄色葡萄球菌适应性实验室进化后仍保持疗效 |
Petersen, M. E. |
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N/A |
Mitomycin C Retains Efficacy after Adaptive Laboratory Evolution of Staphylococcus aureus |
| 小分子激活TFEB通过促进溶酶体胞吐作用和生物发生缓解尼曼-皮克病C型 |
Du, K. |
PDF |
N/A |
Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis |
| 有丝分裂纺锤体的定向和动态变化通过NuMA定位在各向异性组织拉伸的作用下得到了精细调节。 |
Tarannum, N. |
PDF |
N/A |
Mitotic spindle orientation and dynamics are fine-tuned by anisotropic tissue stretch via NuMA localisation |
| TRIM蛋白家族中RING E3假性联酶的鉴定 |
Dudley-Fraser, J. |
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N/A |
Identification of RING E3 pseudoligases in the TRIM protein family |
| Nrf2 调控表观遗传学调节，并在砷诱导的转化过程中作为 KLF4 表达和活性的主调控因子。 |
Wang, Z. |
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N/A |
Nrf2 orchestrates epigenetic regulations and serves as the master regulator of KLF4 expression and activity during arsenic-induced transformation |
| 复制白细胞介素-15超级激动剂的逆转录病毒传递，可增强抗肿瘤免疫并提高低免疫原性胶质母细胞瘤模型中的长期生存率 |
Haddad, A. F. |
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N/A |
Replicating retroviral delivery of an IL-15 superagonist improves antitumor immunity and long-term survival in poorly immunogenic glioblastoma models |
| 复制白细胞介素-15超级激动剂的逆转录病毒传递方式可增强抗肿瘤免疫并提高低免疫原性胶质母细胞瘤模型的长期生存率 |
Haddad, A. F. |
PDF |
N/A |
Replicating retroviral delivery of an IL-15 superagonist improves antitumor immunity and long-term survival in poorly immunogenic glioblastoma models |
| DDX41通过溶解G-四链体来维持红细胞基因组的完整性，并防止cGAS介导的细胞死亡。 |
Bi, H. |
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N/A |
DDX41 dissolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death |
| 芸薹属植物（Brassica campestris L. ssp. chinensis）中生长调节因子BRAGRF5的分子特征及启动子元件分析 |
Wang, X.-Y. |
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N/A |
MOLECULAR CHARACTERIZATION AND PROMOTER ELEMENT ANALYSIS OF GROWTH REGULATOR BRAGRF5 IN BRASSICA CAMPESTRIS L. SSP. CHINENSIS |
| 脱脂辣木籽的生化和植物化学功效在对抗营养不良中的作用 |
Jegede, R. E. |
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N/A |
Biochemical and Phytochemical Efficacy of Defatted Moringa oleifera Seeds in combating Malnutrition |
| 褐藻门三角褐指藻Seipin同源蛋白的功能研究突显了硅藻脂滴生物发生的独特特征。 |
Le Moigne, D. |
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N/A |
Functional study of Phaeodactylum tricornutum Seipin homolog highlights unique features of lipid droplets biogenesis in diatoms. |
| OpenASO：RNA救援——通过社区科学设计剪接调节反义寡核苷酸 |
Tse, V. |
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N/A |
OpenASO: RNA Rescue--designing splice-modulating antisense oligonucleotides through community science |
| 耗竭的贩运调节因子CASK促进间插盘组织和心室功能 |
Blandin, C. E. |
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N/A |
Depleting trafficking regulator CASK promotes intercalated disc organization and ventricular function |
| AAA-ATP酶Cdc48p在过氧化物酶体质量控制中的作用 |
Yusuf, I. F. |
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N/A |
Role of AAA-ATPase Cdc48p in Peroxisomal Quality Control |
| 使用结构化溯祖模型进行病原体系统地理学贝叶斯推断 |
Roberts, I. |
PDF |
N/A |
Bayesian Inference of Pathogen Phylogeography using the Structured Coalescent Model |
| 微生物组如何从血红素中释放铁 |
Nath, A. K. |
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N/A |
How the microbiome liberates iron from heme |
| 一项全面的工程策略提升了针对HIV的近泛中和抗体的效力和生产可行性 |
Sajadi, M. |
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N/A |
A Comprehensive Engineering Strategy Improves Potency and Manufacturability of a Near Pan-neutralizing Antibody Against HIV |
| 通过综合19F-NMR技术比较了人源GPCR在脂质囊泡和水溶液中的构象平衡 |
Ray, A. |
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N/A |
The conformational equilibria of a human GPCR compared between lipid vesicles and aqueous solutions by integrative 19F-NMR |
| 将阿托摩尔级检测带至即时护理点：基于纳米图案DNA折纸的纳米天线技术 |
Yaadav, R. |
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N/A |
Bringing Attomolar Detection to the Point-of-Care with Nanopatterned DNA Origami Nanoantennas |
| 高表达的细胞壁基因有助于花萼大小的稳定性 |
Hartasanchez, D. A. |
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N/A |
Highly expressed cell wall genes contribute to robustness of sepal size |
| 代谢相互作用驱动交叉喂养微生物群落中的种群周期 |
Ross, T. |
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N/A |
Metabolic interplay drives population cycles in a cross-feeding microbial community |
| 热带海鸟（Sula）在加利福尼亚洋流生态系统中数量增加，与海洋变暖条件相关 |
Russell, T. M. |
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N/A |
Increase of tropical seabirds (Sula) in the California Current Ecosystem with warmer ocean conditions |
| 台湾精准医疗计划：大规模研究队列 |
Yang, H.-C. |
PDF |
N/A |
The Taiwan Precision Medicine Initiative: A Cohort for Large-Scale Studies |
| 人类脑组织中RNA质量指标的分析 |
Tian, J. |
PDF |
N/A |
An analysis of RNA quality metrics in human brain tissue |
| 靶向质谱法揭示了啮齿动物多囊卵巢综合征模型中激素和生物活性脂质血浆谱的改变 |
Scott, H. C. |
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N/A |
Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry |
| 在肌肉糖原含量降低的情况下进行耐力运动会影响底物利用，并减弱人类I型和II型肌纤维中的急性mTORC1信号和自噬信号。 |
Horwath, O. |
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N/A |
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers |
| 早期生命病毒组研究中的负样本：特征与去污染 |
Kuzub, N. |
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N/A |
Negativeome in Early-Life Virome Studies: Characterization and Decontamination |
| 微空间尺度下土壤微节肢动物群落构建——一项微宇宙操控研究 |
Dirilgen, T. |
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N/A |
Soil microarthropod community assembly at the micro spatial scale - A microcosm manipulation study |
| Dexrazoxane作为冈比亚按蚊中可行的微孢子虫控制剂 |
Zeferino, T. G. |
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N/A |
Dexrazoxane as a viable microsporidia control agent in Anopheles gambiae |
| 未来气候下褐藻（Ascophyllum nodosum）的热应激：不同种群的敏感性差异。 |
Pereira, L. F. |
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N/A |
Heat Stress on the brown Seaweed Ascophyllum nodosum: differential population sensitivity to future climate. |
| PARMIK：基于廉价K-mer的部分读取匹配 |
Baradaran, M. |
PDF |
N/A |
PARMIK: PArtial Read Matching with Inexpensive K-mers |
| 转录过程中RNA折叠中间体的顺序结构探测 |
Szyjka, C. E. |
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N/A |
Sequential structure probing of cotranscriptional RNA folding intermediates |
| 一种高保真的人类DNA聚合酶全酶具有广泛的损伤旁路活性。 |
Dannenberg, R. L. |
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N/A |
A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities |
| 模拟悬浮细胞的三维折射率分布 |
Borrelli, F. |
PDF |
N/A |
Simulating 3D refractive index distributions of suspended cells |
| 阴离子脂质对阴离子交换蛋白1（AE1）构象转变能量景观的影响 |
Chen, T. |
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N/A |
Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1) |
| 扭转是DNA复制停滞和重新激活的动态调节器 |
Jia, X. |
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N/A |
Torsion is a Dynamic Regulator of DNA Replication Stalling and Reactivation |
| 表达GRK2氨基末端肽转基因小鼠中的女性特异性限制性心肌病与代谢紊乱 |
Bledzka, K. M. |
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N/A |
Female Specific Restrictive Cardiomyopathy and Metabolic Dysregulation in transgenic mice expressing a Peptide of the Amino-Terminus of GRK2 |
| DD基因组的整合重塑了异源六倍体小麦的基因转录、染色质结构和代谢组，从而增强了其适应性。 |
Liu, Y. |
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N/A |
Integration of the DD-genome reshapes gene transcription, chromatin architecture and metabolome of allohexaploid wheat leading to enhanced adaptability |
| Aβ靶向的synNotch受体用于阿尔茨海默病：扩展应用至胞外蛋白聚集体 |
Bergo, N. J. |
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N/A |
Aβ-targeting synNotch Receptor for Alzheimer's Disease: Expanding Applications to Extracellular Protein Aggregates |
| STRAIGHT-IN 双载体系统：一种用于将DNA有效载荷和基因电路双拷贝、单拷贝整合到人类诱导多能干细胞中的平台 |
Blanch Asensio, A. |
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N/A |
STRAIGHT-IN Dual: a platform for dual, single-copyintegrations of DNA payloads and gene circuits into human induced pluripotent stem cells |
| 鸡盲肠中微生物群落的代谢建模揭示了竞争与合作并存的格局 |
Utkina, I. |
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N/A |
Metabolic modeling of microbial communities in the chicken ceca reveals a landscape of competition and co-operation |
| 转录组增强的水稻籽粒代谢模型识别出组氨酸水平作为籽粒粉质度的标志 |
Chowdhury, N. B. |
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N/A |
Transcriptome Enhanced Rice Grain Metabolic Model Identifies Histidine Level as a Marker for Grain Chalkiness |
| 马凡综合征雌性小鼠的皮质神经元中凋亡增加。 |
Esfandiarei, M. |
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N/A |
Apoptosis is increased in cortical neurons of female Marfan Syndrome mice |
| 解开焦虑、自闭和精神病特质对感知推断的影响 |
Bevalot, C. |
PDF |
N/A |
Disentangling the effects of Anxious, Autistic and Psychotic Traits on Perceptual Inference |
| 使用超高分辨率全脑扩散MRI直接分割皮层细胞构筑域 |
Pas, K. E. |
PDF |
N/A |
Direct segmentation of cortical cytoarchitectonic domains using ultra-high-resolution whole-brain diffusion MRI |
| 背景光流会调节多个下行中间神经元对蝗虫中物体运动的反应 |
Zhang, S. |
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N/A |
Background optic flow modulates responses of multiple descending interneurons to object motion in locusts |
| 敲除与LRRK2对抗的RAB磷酸酶PPM1H会破坏轴突自噬并加剧α-突触核蛋白的聚集 |
Fricke, M. |
PDF |
N/A |
Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation |
| m6A介导的表观转录组失调是脆性X综合征中突触功能障碍的基础 |
Guo, Z. |
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N/A |
m6A-mediated epi-transcriptomic dysregulation underlies synaptic dysfunction in fragile X syndrome |
| 血管周围和实质液体的特征与整个生命周期中的年龄和认知表现有关。 |
Lynch, K. M. |
PDF |
N/A |
Perivascular and parenchymal fluid characteristics are related to age and cognitive performance across the lifespan |
| Pep2Vec：一种用于肽-MHC呈递预测和配体组数据集中污染物鉴定的可解释模型 |
Thrift, W. J. |
PDF |
N/A |
Pep2Vec: An Interpretable Model for Peptide-MHC Presentation Prediction and Contaminant Identification in Ligandome Datasets |
| 从重组蛋白自发形成不同形式的α-突触核蛋白纤维 |
Egorov, V. V. |
PDF |
N/A |
Spontaneous formation of different forms of alpha-synuclein fibrils from a recombinant protein |
| 微生物iCLIP2：通过促进蛋白质和RNA的稳定性增强RNA-蛋白质相互作用的映射 |
Stoffel, N. K. |
PDF |
N/A |
Microbial iCLIP2: Enhanced mapping of RNA-Protein interaction by promoting protein and RNA stability |
| BMP-9和BMP-10中链间二硫键形成的分子基础 |
Schwartze, T. A. |
PDF |
N/A |
Molecular basis of interchain disulfide-bond formation in BMP-9 and BMP-10 |
| 拯救迪纳拉山猫：多学科监测与利益相关者参与助力大型食肉动物在人类主导景观中的恢复 |
Krofel, M. |
PDF |
N/A |
Saving the Dinaric lynx: multidisciplinary monitoring and stakeholder engagement support large carnivore restoration in human-dominated landscape |
| 加利福尼亚岩质潮间带的一个包含寄生生物的食物网 |
Zilz, Z. L. |
PDF |
N/A |
A parasite-inclusive food web for the California rocky intertidal zone |
| 评估植物-微生物群落在应对环境胁迫下的相互作用，以增强盐沼恢复效果 |
Davis, K. A. |
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N/A |
Evaluating Plant-Microbe Associations in Response to Environmental Stressors to Enhance Salt Marsh Restoration |
| 保护区是否在追踪对陆地生物多样性的威胁？ |
Pulido Chadid, K. |
PDF |
N/A |
Are protected areas tracking threats to terrestrial biodiversity? |
| 基于谱系的丙型肝炎病毒宿主内动态演化分析 |
Zhao, L. |
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N/A |
Lineage-aware evolutionary analysis of hepatitis C virus within-host dynamics |
| ISWI染色质重塑因子SMARCA5对哺乳动物减数分裂基因表达和雄性生育力至关重要 |
Kataruka, S. |
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N/A |
ISWI chromatin remodeler SMARCA5 is essential for meiotic gene expression and male fertility in mammals |
| 基准贝叶斯共定位方法在验证基于孟德尔随机化的循环蛋白质对心血管代谢疾病目标发现中的应用 |
Zhang, W. |
PDF |
N/A |
Benchmarking Bayesian colocalization methods in validating Mendelian randomization-based target discoveries from circulating proteins for cardiometabolic diseases |
| 人类海马体衰老过程中的表观遗传与三维基因组重编程 |
Zemke, N. |
PDF |
N/A |
Epigenetic and 3D genome reprogramming during the aging of human hippocampus |
| 从南设得兰群岛（南极洲）采集的巨藻鸥（Larus dominicanus）粪便中检测到德尔塔冠状病毒及其他鸟类相关病毒，并进行了全基因组测序。 |
Gomes, F. |
PDF |
N/A |
Detection and full genome sequencing of a Deltacoronavirus and other bird associated viruses from feces of the kelp gull (Larus dominicanus) sampled at the South Shetland Islands Antarctica. |
| 疾病结肠组织中的eQTL鉴定出与IBD相关的新靶基因 |
Nishiyama, N. C. |
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N/A |
eQTL in diseased colon tissue identifies novel target genes associated with IBD |
| 从动物行为和福利的角度来看，监狱犬类训练计划的效果如何？ |
Baria-Unwalla, P. |
PDF |
N/A |
What's in it for the dogs? Assessing the outcomes of a prison-based dog training program from an animal behavior and welfare perspective |
| 端到端多模态深度学习用于实时解码来自同一细胞的数月长神经活动 |
He, Y. |
PDF |
N/A |
End-to-end multimodal deep learning for real-time decoding of months-long neural activity from the same cells |
| 合成与表征氯喹修饰的白蛋白结合siRNA-脂质偶联物，以提高癌细胞内的递送效率和基因沉默效果 |
Lo, J. H. |
PDF |
N/A |
Synthesis and characterization of chloroquine-modified albumin-binding siRNA-lipid conjugates for improved intracellular delivery and gene silencing in cancer cells |
| 特定领域人工智能对小鼠胚胎干细胞中IMPDH2杆/环结构的分割 |
Ball, S. T. M. |
PDF |
N/A |
Domain Specific AI Segmentation of IMPDH2 Rod/Ring Structures in Mouse Embryonic Stem Cells |
| 肺炎克雷伯菌株在白蚁、黑猩猩和人类之间的循环 |
Houmenou, C. T. |
PDF |
N/A |
Circulation of Klebsiella pneumoniae strains between the termites, chimpanzees and humans |
| 微生物组数据分析的半合成模拟 |
Sankaran, K. |
PDF |
N/A |
Semisynthetic Simulation for Microbiome Data Analysis |
| 基于上下文的细菌基因组蛋白质功能预测 |
Toibazar, D. |
PDF |
N/A |
Context-based protein function prediction in bacterial genomes |
| 扩展和改进核苷酸重编码RNA-seq实验分析的EZbakR套件 |
Vock, I. |
PDF |
N/A |
Expanding and improving analyses of nucleotide recoding RNA-seq experiments with the EZbakR suite |
| EGFR与酪氨酸激酶抑制剂相互作用的氢氘交换质谱（HDX-MS）研究 |
Ashtekar, K. D. |
PDF |
N/A |
EGFR and tyrosine kinase inhibitor interactions probed by hydrogen-deuterium exchange and mass spectrometry (HDX-MS) |
| CDK4/6与PI3K抑制剂的新型组合在尤文肉瘤中展现出高度协同作用及转化潜力。 |
De Los Santos, M. A. I. C. |
PDF |
N/A |
A novel combination of CDK4/6 and PI3K inhibitors exhibits highly synergistic activity and translational potential in Ewing sarcoma. |
| F(ab)'2片段相对于IgG在RIT和PRIT中的优势 |
Tabaja, Z. E. |
PDF |
N/A |
Advantage of the F(ab)'2 fragment over IgG for RIT and PRIT |
| 整合的人类骨骼肌单细胞功能蛋白质组学分析揭示了nemaline肌病中细胞特异性的转变 |
Seaborne, R. A. E. |
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N/A |
Integrated single cell functional-proteomic profiling of human skeletal muscle reveals a shift in cellular specificity in nemaline myopathy |
| 光呼吸的替代方案：系统级分析揭示了提高植物生产力的机制 |
Smith, E. N. |
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N/A |
Alternatives to photorespiration: A systems-level analysis reveals mechanisms of enhanced plant productivity |
| 利用昼夜节律钟调控的顺式调控突变，构成了自然选择下阿拉伯芥哈勒里极端性状的基础。 |
Castanedo, L. |
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N/A |
Cis-regulatory mutations co-opting circadian clock regulation underlie naturally selected extreme trait in Arabidopsis halleri |
| 溢出率并不能预测宿主跳跃的风险。 |
Simony, B. J. |
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N/A |
Spillover rate is not predictive of host jump risk |
| 一份详尽的蛋白质组和磷酸蛋白质组在不同小鼠组织和脑区中的周转图谱 |
Li, W. |
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N/A |
An Extensive Atlas of Proteome and Phosphoproteome Turnover Across Mouse Tissues and Brain Regions |
| 微生物产生的胆汁酸与纤维肌痛患者中高水平IgG自身抗体和较差的心理健康状况相关。 |
Jakobsson, J. E. |
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N/A |
Microbially produced bile acids are associated with high levels of IgG autoantibodies and worse mental wellbeingin fibromyalgia subjects |
| 空间频率通道介导了人类空间知觉的视觉度量 |
Zhang, S. |
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N/A |
Spatial frequency channels mediate a visual metric for human spatial perception |
| 时间泛化有界积累模型优于现有模型，并能捕捉模态差异和学习效应。 |
Ofir, N. |
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N/A |
A bounded accumulation model of temporal generalization outperforms existing models and captures modality differences and learning effects |
| 正念训练影响与青少年压力反应相关的大脑网络动态。 |
Gaviria, J. |
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N/A |
Mindfulness training impacts brain network dynamics linked to stress response in young adolescents. |
| Nlrp3的遗传消除可防止散发性和R345W Efemp1诱导的基底层沉积物形成 |
Ortega, A. J. |
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N/A |
Genetic removal of Nlrp3 protects against sporadic and R345W Efemp1-induced basal laminar deposit formation |
| SARS-CoV-2 XEC变种的病毒学特征 |
Kaku, Y. |
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N/A |
Virological characteristics of the SARS-CoV-2 XEC variant |
| SFSWAP是OGT内含子滞留和全局前体mRNA剪接的负调控因子 |
Govindan, A. |
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N/A |
SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing |
| 在大陆尺度的样地网络中，探测生态系统对气候变化和干扰响应的趋势：一项功效分析 |
Guerin, G. R. |
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N/A |
Detecting ecosystem trends in response to climate and disturbance across continental plot networks: a power analysis |
| 细菌-噬菌体（共）进化在合成群落中受到多对细菌-噬菌体相互作用的限制 |
Castledine, M. |
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N/A |
Bacteria-phage (co)evolution is constrained in a synthetic community across multiple bacteria-phage pairs |
| 用于评估体外细胞表型与整体生物表型相关性的遗传工具变量框架 |
Howe, L. J. |
PDF |
N/A |
Genetic instrumental variable framework for assessing relevance of in-vitro cellular phenotypes to organism-level phenotypes |
| 对9,482株结核分枝杆菌的拷贝数变异分析揭示了谱系特异性分子决定因素。 |
Bhalla, N. |
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N/A |
Copy number variation analysis of 9,482 Mycobacterium tuberculosis isolates identifies lineage-specific molecular determinants. |
| 弯果蓝蓟（Pectocarya recurvata）染色体水平参考基因组，该物种是紫草科中基因组最小的物种之一。 |
Northing, P. C. |
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N/A |
Chromosome-scale reference genome of Pectocarya recurvata, a species with one of the smallest genome sizes in Boraginaceae |
| 小分子配体选择性结合RNA单链G凸起的机理研究 |
Hegde, S. |
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N/A |
Mechanistic Studies of Small Molecule Ligands Selective to RNA Single G Bulges |
| 在人体颈动脉中，如果不进行层分离，无法揭示无应力状态。 |
Hrubanova, A. |
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N/A |
Stress-free state in human carotid arteries cannot be revealed without layer separation |
| 使用中位数对单细胞DNA甲基化数据中的缺失值进行插补是一种直接且有效的方法。 |
Tang, S. |
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N/A |
Imputing not available values in single-cell DNA methylation data using the median is straightforward and effective |
| 报告H：确定重复序列在基因组间的直系同源位置 |
Bharadwaj, P. V. |
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N/A |
REPORTH: Determining orthologous locations of repetitive sequences between genomes |
| 利用药效团建模、QSAR、对接、ADMET、分子动力学和DFT分析发现天然MCL1抑制剂 |
Das, U. |
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N/A |
Discovery of Natural MCL1 Inhibitors using Pharmacophore modelling, QSAR, Docking, ADMET, Molecular Dynamics, and DFT Analysis |
| 自动检测和提取生物医学论文表格中的关键资源 |
Ozyurt, I. B. |
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N/A |
Automatic Detection and Extraction of Key Resources from Tables in Biomedical Papers |
| KinPFN：使用先验数据拟合网络的RNA折叠动力学贝叶斯近似 |
Scheuer, D. |
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N/A |
KinPFN: Bayesian Approximation of RNA FoldingKinetics using Prior-Data Fitted Networks |
| 一种用于药物反应预测的多模态基因组知识蒸馏框架 |
Ge, S. |
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N/A |
A Multi-Modal Genomic Knowledge Distillation Framework for Drug Response Prediction |
| 使用串联质谱库注释全扫描质谱数据 |
Xing, S. |
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N/A |
Annotating full-scan MS data using tandem MS libraries |
| 评估AlphaFold2预测的白链结构域构建体的有效性。 |
Mitic, I. |
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N/A |
Assessing the Validity of Leucine Zipper Constructs Predicted in AlphaFold2. |
| 利用微流控技术、延时相差显微镜和深度学习快速鉴定七种细菌种类 |
Hallström, E. |
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N/A |
Rapid identification of seven bacterial species using microfluidics, time-lapse phase-contrast microscopy, and deep learning |
| 吉波替达辛和左利福达辛如何稳定细菌IIA型拓扑异构酶的DNA切割复合物？2. 单一移动金属机制。 |
Nicholls, R. A. |
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N/A |
How do gepotidacin and zolifodacin stabilize DNA-cleavage complexes with bacterial type IIA topoisomerases? 2. A Single Moving Metal Mechanism. |
| PAR4反应性降低的小鼠表现出静脉血栓形成减少和血小板促凝活性降低 |
Knauss, E. A. |
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N/A |
Mice with Reduced PAR4 Reactivity show Decreased Venous Thrombosis and Platelet Procoagulant Activity |
| 苔藓植物小立碗藓中生长素介导的基因激活作用 |
Bascom, C. S. |
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N/A |
The role of auxin-mediated gene activation in the bryophyte, Physcomitrium patens |
| 蛋白质解聚酶HSP101对易聚集蛋白质HSA32的稳定作用，在维持拟南芥获得性耐热性中起着关键作用。 |
Mitra, S. |
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N/A |
Stabilization of HSA32, an aggregation-prone protein, by the protein disaggregase HSP101 plays a critical role in maintaining acquired thermotolerance in Arabidopsis |
| APOE基因型和生物学年龄影响与生物能量学相关的多组学关联 |
Ellis, D. S. |
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N/A |
APOE Genotype and Biological Age Impact Inter-Omic Associations Related to Bioenergetics |
| 参数依赖性在可识别性中的应用：应用于Tauopathy网络建模参数化的FP-Fisher-KPP反应扩散方程 |
Rahimabadi, A. |
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N/A |
Parameter Dependence in Identifiability Applied to FP-Fisher-KPP Reaction-Diffusion Equations Parameterized for Tauopathy Network Modeling |
| 在磁肌电图检测中识别单个运动单位活动 |
Noury, N. |
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N/A |
Detecting single motor-unit activity in magnetomyography |
| 揭示星形胶质网络的功能连接性：AstroNet，一种结合图像处理的图重建算法 |
Zonca, L. |
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N/A |
Unveiling the Functional Connectivity of Astrocytic Networks with AstroNet, a Graph Reconstruction Algorithm Coupled to Image Processing |
| 皮质微电路在强化学习中的区域特定信用分配 |
Chevy, Q. |
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N/A |
A Cortical Microcircuit for Region-Specific Credit Assignment in Reinforcement Learning |
| 户外空气污染与青春期早期杏仁核亚区体积及分布有关 |
Morrel, J. |
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N/A |
Outdoor Air Pollution Relates to Amygdala Subregion Volume and Apportionment in Early Adolescents |
| 预测性处理和知觉负荷在选择性视觉注意中的作用：对语义显著和较少显著干扰项的考察 |
Ozsu, A. B. |
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N/A |
The Role of Predictive Processing and Perceptual Load in Selective Visual Attention: An Examination with Semantically Salient and Less Salient Distractors |
| 成纤维细胞将上皮营养感应与ILC2-簇细胞回路放大相连接 |
Liao, C. |
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N/A |
Telocytes link epithelial nutrient sensing with amplification of the ILC2-tuft cell circuit |
| 了解溃疡性结肠炎患者对JAK抑制剂无反应的机制 |
Melon-Ardanaz, E. |
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N/A |
Understanding the mechanisms underlying the lack of response to Janus kinase inhibition in ulcerative colitis |
| 盘尾丝虫空间蛋白质组学与多形性肿瘤显示蛋白质表达的局部和系统性失调 |
Di Maggio, L. S. |
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N/A |
Spatial proteomics of Onchocerca volvulus with pleomorphic neoplasms shows local and systemic dysregulation of protein expression |
| 树木在单种和混种邻域中的生物量分配 |
Perles-Garcia, M. D. |
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N/A |
Biomass allocation of trees in response to mono- and heterospecific neighbourhoods |
| 用于生长细根的碳的14C年龄反映了树木的碳状态。 |
Hilman, B. |
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N/A |
14C-age of carbon used to grow fine roots reflects tree carbon status |
| 缺氧导致珊瑚迅速死亡——对珊瑚礁构成的新兴危险威胁 |
Dhillon, M. S. |
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N/A |
Oxygen deprivation implicated in rapid coral mortality -- an emerging perilous threat to coral reefs |
| 利用全球HLA数据提升iPSC配型库中的患者匹配效果 |
Maiers, M. |
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N/A |
Harnessing Global HLA Data for Enhanced Patient Matching in iPSC Haplobanks |
| 野生小麦近缘种Aegilops comosa的染色体规模组装与注释 |
Li, H. |
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N/A |
Chromosome-scale assembly and annotation of the wildwheat relative Aegilops comosa |
| 通过建模数字PCR的统计特征，改进废水流行病学中的推断 |
Lison, A. |
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N/A |
Improving inference in wastewater-based epidemiology by modelling the statistical features of digital PCR |
| 用于罕见疾病药物再利用的知识图谱与可解释人工智能 |
Perdomo-Quinteiro, P. |
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N/A |
Knowledge Graphs and Explainable AI for Drug Repurposing on Rare Diseases |
| 在单细胞和空间转录组学中评估替代多聚腺苷酸化检测方法 |
Li, S. |
PDF |
N/A |
Benchmarking alternative polyadenylation detection in single-cell and spatial transcriptomes |
| DEMINERS通过提高纳米孔直接RNA测序的通量和准确性，实现了临床宏基因组学和比较转录组学分析。 |
Song, J. |
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N/A |
DEMINERS enables clinical metagenomics and comparative transcriptomic analysis by increasing throughput and accuracy of nanopore direct RNA sequencing |
| 在生物语言模型中，跨生物分子模态的知识传递 |
Prakash, M. |
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N/A |
Bridging biomolecular modalities for knowledge transfer in bio-language models |
| 吉波替达辛和左利福达辛如何稳定与细菌IIA型拓扑异构酶的DNA切割复合物？1. 金属结合位点的实验定义 |
Morgan, H. |
PDF |
N/A |
How do gepotidacin and zoliflodacin stabilize DNA-cleavage complexes with bacterial type IIA topoisomerases? 1. Experimental definition of metal binding sites |
| 通过唾液生物标志物评估学术压力：皮质醇、IL-1β、CRP和IgA水平及其性别差异的多变量分析。 |
Klagges, R. C. |
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N/A |
Academic stress through salivary biomarkers: A multivariate analysis of cortisol, IL-1β, CRP, and IgA levels and their variations as a function of sex. |
| 利用多环境全基因组关联分析方法研究自然感染条件下石果园中生物胁迫响应的遗传结构 |
Serrie, M. |
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N/A |
Investigating the genetic architecture of biotic stress response in stone fruit tree orchards under natural infections with a multi-environment GWAS approach |
| 一项基于模型的元分析支持了新兴的共识观点，即抑制性神经元主导了BOLD-fMRI反应。 |
Sundqvist, N. |
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N/A |
A Model-Driven Meta-Analysis Supports the Emerging Consensus View that Inhibitory Neurons Dominate BOLD-fMRI Responses |
| 通过结合新型竞争范式与现有范式揭示的小鼠社会能力与地位的刻板印象 |
Liu, M. |
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N/A |
Stereotype of mouse social competency and status revealed by a novel competition paradigm in combination with available paradigms |
| 揭示帕金森病患者运动学习动态 |
Kim, A. |
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N/A |
Uncovering locomotor learning dynamics in people with Parkinson's disease |
| 雄性附腺基因的快速启动子进化伴随着在密切相关的果蝇物种中的差异表达 |
McQuarrie, D. W. J. |
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N/A |
Rapid promoter evolution of male accessory gland genes is accompanied by divergent expression in closely related Drosophila species |
| 尼日利亚养殖和野生非洲鲶鱼（Clarias gariepinus）的遗传多样性、种群结构和分化 |
Sanda, M. K. |
PDF |
N/A |
Genetic diversity, population structure and differentiation of farmed and wild African catfish (Clarias gariepinus) in Nigeria |
| 依赖ATP的蛋白酶ClpYQ在枯草芽孢杆菌中降解细胞分裂蛋白DivIVA和Mbl |
Lasnosky, T. D. |
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N/A |
The ATP-dependent protease ClpYQ degrades cell division proteins DivIVA and Mbl in Bacillus subtilis |
| 单羧酸转运蛋白转运甲状腺素的分子机制 |
Tassinari, M. |
PDF |
N/A |
Molecular mechanism of thyroxine transport by monocarboxylate transporters |
| 利用大型语言模型和基因编辑元数据库探索基因编辑信息的管道 |
Suzuki, T. |
PDF |
N/A |
Pipeline to explore information on genome editing using large language models and genome editing meta-database |
| 氟NMR研究氨基酸衍生的配体以研究TSPO |
Duma, L. |
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N/A |
Fluor NMR study of amino acid derived ligand to study TSPO |
| 一个共同保守的基因对在螯合应激期间维持柄杆菌的铁稳态中起作用 |
Ortiz, S. H. |
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N/A |
A co-conserved gene pair supports Caulobacter iron homeostasis during chelation stress |
| 大肠杆菌在合成废水和实际废水中的抗生素抗性发展特征 |
Sutradhar, I. |
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N/A |
Characterization of antibiotic resistance development of E. coli in synthetic and real wastewater |
| 早期抗生素暴露会导致肠道菌群失调，这种失调与神经发育和神经再生有关。 |
Zhao, Q. |
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N/A |
Early-life antibiotic exposure leads to gut microbial dysbiosis associated with neurodevelopment and neuroregeneration |
| Trim7在体内对小鼠诺如病毒感染的限制中没有作用。 |
Annaswamy Srinivas, M. |
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N/A |
Trim7 does not have a role in the restriction of murine norovirus infection in vivo |
| 利用番茄废弃物提取物增强着色菌（Exiguobacterium aurantiacum）的色素生产：一种统计学方法 |
Zeleke, B. |
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N/A |
Enhancing pigment production by a chromogenic bacterium (Exiguobacterium aurantiacum) using tomato waste extract: A Statistical approach |
| SMC 调节链霉菌中分离复合体中 ParB 的参与 |
Pawlikiewicz, K. |
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N/A |
SMC modulates ParB engagement in segregation complexes in Streptomyces |
| 鉴定SLC35A1为多血清型重组腺相关病毒（AAV）载体转导的关键宿主因子 |
Zhang, X. |
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N/A |
Identification of SLC35A1 as an essential host factor for the transduction of multi-serotype recombinant adeno-associated virus (AAV) vectors |
| 自发T2DM猕猴的多组学研究揭示肠道微生物通过上调过量棕榈酸的吸收促进T2DM |
Liu, X. |
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N/A |
Multi-omics investigation of spontaneous T2DM macaque reveals gut microbiota promote T2DM by up-regulating the absorption of excess palmitic acid |
| 在持续念珠菌血症期间和基线时的血液培养物中，含有遗传多样性不同的白色念珠菌菌株，这些菌株在棘白菌素耐药性和毒力方面可能存在差异。 |
Fleres, G. |
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N/A |
Blood cultures at baseline and during persistent candidemia contain populations of genetically diverse Candida albicans strains that may differ in echinocandin tolerance and virulence |
| 指导多物种有益生物膜的组装，以针对不良细菌 |
Gueneau, V. |
PDF |
N/A |
Guided assembly of multispecies positive biofilms targeting undesirable bacteria |
| 肌球蛋白轻链3通过巨胞饮途径作为神经坏死病毒进入宿主细胞的受体 |
Yao, L. |
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N/A |
Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway |
| 通过同时进行转录起始位点定位和甲基化定量来解析m6Am |
Liu, J. F. |
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N/A |
Decoding m6Am by simultaneous transcription-start mapping and methylation quantification |
| 靶向降解HPV癌蛋白E6可减轻宫颈癌的肿瘤负担 |
Smalley, T. B. |
PDF |
N/A |
Targeted degradation of the HPV oncoprotein E6 reduces tumor burden in cervical cancer |
| 一种用于多环四胺大环内酰胺表达和功能化的即插即用系统 |
Gloeckle, A. |
PDF |
N/A |
A Plug-and-Play System for Polycyclic Tetramate Macrolactam Expression and Functionalization |
| 胚胎细胞起源及缺氧介导机制在PIK3CA驱动难治性血管畸形中的作用 |
Torii, S. |
PDF |
N/A |
Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-Driven refractory vascular malformations |
| 一种首创的双降解剂，针对Bcl-2/Bcl-xL，能够逆转HIV潜伏状态并消除体外储藏库 |
Chang, L.-C. |
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N/A |
A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Eliminates Ex Vivo Reservoirs |
| rRNA特异性反义DNA和双链DNA触发rRNA生物合成，并对柑橘害虫Coccus hesperidum L.产生强大的杀虫效果。 |
Oberemok, V. V. |
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N/A |
rRNA-specific antisense DNA and dsDNA trigger rRNA biogenesis and cause potent insecticidal effect on insect pest Coccus hesperidum L. |
| 鉴定眼病病原体棘阿米巴的包囊（四种）和滋养体（一种）的新诊断靶标 |
Sundararaj, B. K. |
PDF |
N/A |
Identification of new targets for the diagnosis of cysts (four) and trophozoites (one) of the eye pathogen Acanthamoeba |
| 通过在人类线粒体中重构末端连接来生成线粒体DNA缺失 |
sfeir, a. |
PDF |
N/A |
Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria |
| 利用双特异性抗体实现mRNA靶向递送，将脂质纳米颗粒（LNPs）锚定于细胞表面标志物 |
Dietmair, B. |
PDF |
N/A |
Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markers |
| 用于活细胞和体内成像的荧光阴离子菁染料质膜探针 |
Danylchuk, D. I. |
PDF |
N/A |
Fluorescent anionic cyanine plasma membrane probes for live cell and in vivo imaging |
| 酮体生成通过脂肪氧化非依赖性机制保护免受MASLD-MASH进展的影响 |
Queathem, E. D. |
PDF |
N/A |
Ketogenesis protects against MASLD-MASH progression through fat oxidation-independent mechanisms |
| METTL3-METTL14对Drosha-DGCR8介导的初级microRNA加工的影响 |
Khadgi, B. B. |
PDF |
N/A |
Effects of METTL3-METTL14 on primary microRNA processing by Drosha-DGCR8 |
| 媒体品牌对头孢地尔盘扩散结果的影响 |
DeMarco, M. G. |
PDF |
N/A |
Impact of media brand on cefiderocol disk diffusion results |
| TamL是拟杆菌门中维持外膜稳态的关键因子。 |
Giovannercole, F. |
PDF |
N/A |
TamL is a key player of the outer membrane homeostasis in Bacteroidetes. |
| 实验室的可持续性：评估微孔板在PCR和片段检测中的重复使用性 |
Berthelsen, A. L. |
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N/A |
Sustainability in the laboratory: evaluating the reuseability of microtiter plates for PCR and fragment detection |
| 从淡水斑马贻贝（Dreissena bugensis）中提取的湿粘附蛋白的鉴定与表征 |
Obille, A. R. |
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Identification and characterization of a wet adhesive protein extracted from Dreissena bugensis, the freshwater quagga mussel |
| 两个保守的精氨酸残基促进Suf家族半胱氨酸脱硫酶中的C-S键断裂和硫化物转移。 |
Gogar, R. K. |
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Two conserved arginine residues facilitate C-S bond cleavage and persulfide transfer in Suf family cysteine desulfurases. |
| 克拉伯病GALC错义变异的表达研究——基于残留酶活性、分泌量及神经鞘氨醇半乳糖苷水平的定量分析所获得的洞见 |
Peng, H. |
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Expression study of Krabbe Disease GALC missense variants -- Insights from quantification profiles of residual enzyme activity, secretion and psychosine levels |
| MLL/WDR5复合体招募KIF2C至中间体，以确保在有丝分裂期间微管解聚和收缩环压缩。 |
Kataria, A. |
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MLL/WDR5 complex recruits KIF2C to midbody to ensure MT depolymerization and furrow compaction during cytokinesis |
| 由Mnl1甘露糖苷酶和蛋白质二硫键异构酶双功能复合物启动的内质网相关降解（ERAD）过程 |
Zhao, D. |
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Initiation of ERAD by the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase |
| ZO-2支架机制调控Hippo信号通路。 |
Liu, O. |
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A ZO-2 scaffolding mechanism regulates the Hippo signalling pathway. |
| 细胞周期蛋白A和细胞周期蛋白B的mRNA转录后调控由Bruno 1和Cup介导，并在P-bodies内进一步微调。 |
Bayer, L. V. |
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Post-transcriptional regulation of cyclin A and cyclin B mRNAs is mediated by Bruno 1 and Cup, and further fine-tuned within P-bodies |
| 一种残留角膜缘干细胞的角膜缘干细胞缺乏小鼠模型 |
Someya, H. |
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A limbal stem cell deficiency murine model with residual limbal stem cells |
| 乳腺上皮细胞迁移与上皮-间质转化无关 |
Chen, J. |
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N/A |
Mammary Epithelial Migration is EMT-Independent |
| 中性粒细胞表现出不同的迁移表型，这些表型受跨内皮迁移的调节。 |
Schwartz, A. B. |
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Neutrophils exhibit distinct migration phenotypes that are modulated by transendothelial migration |
| 柠檬酸合酶通过重构巨噬细胞的线粒体三羧酸循环，改善了脓毒症诱导的肺损伤。 |
Sun, J. |
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Citrate synthase improves sepsis-induced lung injury by reconstructing the mitochondrial tricarboxylic acid cycle of macrophages |
| 选择性静止期酵母细胞的协调分工扩大了休眠期种群的存活率 |
Hsiao, K.-C. |
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Coordinated Division of Selective Stationary-Phase Yeast Cells Expands the Population Survivorship in Quiescence |
| 可视化果蝇核形态和运输机制的发育动力学 |
Shindo, Y. |
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N/A |
Visualizing developmental dynamics of nuclear morphology and transport machinery in Drosophila |
| 在诱导关节炎症后，肠道炎症和免疫转录物被沉默的证据 |
Moran, M. M. |
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Evidence of Silencing of Intestinal Inflammatory and Immune Transcripts Following Induction of Joint Inflammation |
| 小分子定向分化浸没培养的人鼻气道上皮用于呼吸疾病建模 |
Dreyer, H. H. M. |
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Small molecule-directed differentiation of submerged-cultured human nasal airway epithelia for respiratory disease modelling |
| 物理信息椭球坐标编码隐式神经表示用于高分辨率体积宽视野显微镜 |
Zhou, Y. |
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Physics-Informed Ellipsoidal Coordinate Encoding Implicit Neural Representation for high-resolution volumetric wide-field microscopy |
| 羟基脲诱导内质网应激和细胞质蛋白聚集 |
Sanchez-Molina, A. |
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N/A |
Hydroxyurea induces ER stress and cytoplasmic protein aggregation |
| 初级纤毛通过音猬信号通路塑造出生后星形胶质细胞的发育 |
Bear, R. |
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Primary cilia shape postnatal astrocyte development through Sonic Hedgehog signaling |
| 儿童在标准与奖励性Go/No-Go任务需求下大脑网络的差异重构 |
Mitchell, M. E. |
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Differential reconfiguration of brain networks in children in response to standard versus rewarded go/no-go task demands |
| 冬眠哺乳动物适应性生理转变背后的基因 |
Drabeck, D. H. |
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Genes Underlying Adaptive Physiological Shifts Among Hibernating Mammals |