| 刺激前大规模功能连接的动态变化决定了多感官任务中的表现 |
Galindo Leon, E. E. |
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Dynamic changes in large-scale functional connectivity prior to stimulation determine performance in a multisensory task |
| 从单细胞和空间转录组学揭示的结直肠癌中空间定义的多细胞功能单元 |
Avraham-Davidi, I. |
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Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics |
| 一种含有催产素阳性物质的腰脊髓神经元群体调节性兴奋和交配行为。 |
Lenschow, C. |
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A galanin-positive population of lumbar spinal cord neurons modulates sexual arousal and copulatory behavior |
| 脂质稳态受损通过ESCRT破坏导致溶酶体内源性蛋白聚集体的积累 |
Yong, J. |
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Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption |
| 老化大脑中广泛的不确定性调整抑制 |
Kosciessa, J. Q. |
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Broadscale dampening of uncertainty adjustment in the aging brain |
| 通过肽距离分析评估TCR结合预测器的泛化能力 |
Castorina, L. V. |
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Assessing the Generalization Capabilities of TCR Binding Predictors via Peptide Distance Analysis |
| 一种可调的极简细胞膜揭示出，两种脂质种类足以维持生命 |
Justice, I. G. |
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A tuneable minimal cell membrane reveals that two lipid species suffice for life |
| 从自拍到科学 - 使用iPhone 13进行精确的3D叶片测量及其对植物发育和蒸腾作用的启示 |
Bar-Sella, G. |
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From Selfies to Science - Precise 3D Leaf Measurement with iPhone 13 and Its Implications for Plant Development and Transpiration |
| RmlT是一种调节李斯特菌单胞菌毒力的壁磷壁酸鼠李糖基转移酶的分子特性。 |
Monteiro, R. |
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Molecular properties of RmlT, a wall teichoic acid rhamnosyltransferase that modulates virulence in Listeria monocytogenes. |
| 在动物的近亲之一中，由盐度引发的克隆聚集性多细胞性 |
Ros-Rocher, N. |
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Clonal-aggregative multicellularity entrained by salinity in one of the closest relative of animals |
| 在羧基末端结构域内带负电的区域维持了CTCF与DNA的正确结合。 |
Liu, L. |
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A negatively-charged region within carboxy-terminal domain maintains proper CTCF DNA binding |
| 通过基因调控表型鉴定出的丹尼索瓦人候选化石 |
Mishol, N. |
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Candidate Denisovan fossils identified through gene regulatory phenotyping |
| 预测帕金森病中病理学性丘脑底核β爆发的发生 |
Abdi-Sargezeh, B. |
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Prediction of pathological subthalamic nucleus beta burst occurrence in Parkinson's disease |
| 前胫骨平移产生的大量制动力可诱导小鼠前十字韧带的自发性愈合 |
Saito, R. |
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Substantial Braking Force of Anterior Tibial Translation Induces the Spontaneous Healing of Murine Anterior Cruciate Ligament |
| 刺激前β波功率在不同皮质区域介导显性和隐性知觉偏差 |
Forster, C. |
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Pre-stimulus beta power mediates explicit and implicit perceptual biases in distinct cortical areas |
| scCancerExplorer：一个综合数据库，用于交互式探索人类泛癌单细胞多组学数据 |
Huang, C. |
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scCancerExplorer: a comprehensive database for interactively exploring single-cell multi-omics data of human pan-cancer |
| 机械拉伸足细胞中的选择性剪接作为肾小球高血压的模型 |
Mattias, F. |
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Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertension |
| PA28γ通过提升线粒体功能，促进肿瘤的恶性进展，这一过程涉及C1QBP。 |
Wang, J. |
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PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP |
| 利用时间数据对调控内皮屏障完整性的激酶磷酸信号网络进行系统级重构 |
Wei, L. |
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Systems-level reconstruction of kinase phosphosignaling networks regulating endothelial barrier integrity using temporal data |
| 内在动态在人脑对外部刺激的反应中起着重要作用。 |
Nentwich, M. |
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Intrinsic dynamic shapes responses to external stimulation in the human brain |
| 预测无关信息：干扰项可预测性的神经效应取决于认知负荷 |
Lui, T. K.-Y. |
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Predicting the irrelevant: Neural effects of distractor predictability depend on load |
| 刺胞动物胚胎中的平面细胞极性协调为动物体轴的进化提供了线索。 |
Uveira, J. |
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Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution |
| 定性脑电图异常提示大脑网络向抑制主导型转变。EU-AIMS LEAP研究的结果显示了这一点。 |
Juarez-Martinez, E. L. |
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Qualitative EEG abnormalities signal a shift towards inhibition-dominated brain networks. Results from the EU-AIMS LEAP studies |
| 海洋群岛进化辐射的生物地理学 |
Bree, B. |
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The biogeography of evolutionary radiations on oceanic archipelagos |
| 解析苯基琥珀酸合酶的对映选择性机制：通过多尺度建模和动力学研究厌氧烃降解的启示 |
Szaleniec, M. |
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Unravelling the Enantioselective Mechanism of Benzylsuccinate Synthase: Insights into Anaerobic Hydrocarbon Degradation Through Multiscale Modelling and Kinetics |
| 利用dCas引导的邻近标记技术在曲霉菌中进行位点特异性染色质蛋白质组学研究。 |
Svoboda, T. |
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Locus-specific chromatin proteomics using dCas-guided proximity labelling in Aspergillus nidulans. |
| 从动物行为和福利的角度来看，监狱犬训练项目的效果如何？ |
Baria-Unwalla, P. |
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What's in it for the dogs? Assessing the outcomes of a prison-based dog training program from an animal behavior and welfare perspective |
| 使用中位数对单细胞DNA甲基化数据中不可用值进行插补，既直接又有效。 |
Tang, S. |
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Imputing not available values in single-cell DNA methylation data using the median is straightforward and effective |
| 利用微流控技术、延时相差显微镜和深度学习快速鉴定七种细菌种类 |
Hallström, E. |
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Rapid identification of seven bacterial species using microfluidics, time-lapse phase-contrast microscopy, and deep learning |
| 人类星形胶质细胞同步化神经类器官网络 |
Patel, M. D. |
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Human Astrocytes Synchronize Neural Organoid Networks |
| FBXW7通过调节MYRF水平来控制成年中枢神经系统中髓鞘的容量和稳态 |
Collins, H. Y. |
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FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS |
| 通过组织特异性表达变化实现剂量敏感基因的进化 |
Rice, A. M. |
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Evolution of dosage-sensitive genes by tissue-restricted expression changes |
| 暂时性脑缺血损害了血栓素A2的收缩作用，并诱导了高血压大鼠外周肠系膜动脉的肥厚性重塑，尽管长期使用亚油酰胺羟肟酸进行脑保护，但逆转效果有限。 |
Diaz-Perez, A. |
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Temporary cerebral ischaemia impairs thromboxane A2 constriction and induces hypertrophic remodelling in peripheral mesenteric arteries of hypertensive rats: limited reversal despite long-term suberoylanilide hydroxamic acid cerebroprotection |
| 抑制PDGFRβ信号增强肌细胞融合以促进骨骼肌再生 |
Xue, S. |
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Suppressing PDGFRβ Signaling Enhances Myocyte Fusion to Promote Skeletal Muscle Regeneration |
| 单轴力在青春期发育过程中改变乳腺导管网络的长度和导管的方向：来自计算建模和实验室实验的发现 |
George, U. Z. |
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Uniaxial force modifies the length of the mammary ductal network and the orientation of ducts during pubertal development: Findings from computational modeling and laboratory experiments |
| 单轴力在青春期发育过程中改变乳腺导管网络的长度和导管的方向：来自计算建模和实验室实验的发现 |
George, U. Z. |
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Uniaxial force modifies the length of the mammary ductal network and the orientation of ducts during pubertal development: Findings from computational modeling and laboratory experiments |
| 在净化选择下的家谱 |
Khudiakova, K. A. |
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Genealogies under purifying selection |
| 估计利什曼原虫的有性生殖率和近交率 |
Nicoll, A. G. |
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Estimating the rate of sexual reproduction and the inbreeding rate in Leishmania |
| ybx1通过上游调控atoh1a，促进斑马鱼侧线神经丘毛细胞的快速再生。 |
Reagor, C. C. |
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ybx1 acts upstream of atoh1a to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts |
| 一种谱系特异性新生RNA检测揭示了组织生物学中基因调控的原理 |
Chovatiya, G. |
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A lineage-specific nascent RNA assay unveils principles of gene regulation in tissue biology |
| 血小板单细胞转录组的首份全面描述 |
Wolfsberger, W. |
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The First Comprehensive Description of the Platelet Single Cell Transcriptome |
| 转录组和文本的多模态学习使得通过自然语言聊天实现单细胞RNA测序数据的交互式探索成为可能。 |
Schaefer, M. |
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Multimodal learning of transcriptomes and text enables interactive single-cell RNA-seq data exploration with natural-language chats |
| 在个性化基因组序列上训练深度学习模型可提高变异效应预测的准确性。 |
He, A. Y. |
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Training deep learning models on personalized genomic sequences improves variant effect prediction |
| 用区间假设替代归一化方法可提高差异表达和差异丰度分析的严谨性和鲁棒性 |
McGovern, K. C. |
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Replacing Normalizations with Interval AssumptionsImproves the Rigor and Robustness of DifferentialExpression and Differential Abundance Analyses |
| 人类拓扑异构酶IIα通过相变促进染色质凝聚 |
Wu, M. |
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Human Topoisomerase IIα Promotes Chromatin Condensation Via a Phase Transition |
| CcdA通过共翻译折叠机制保护CcdB免受不可逆错误折叠和聚集。 |
Bajaj, P. |
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CcdA chaperones CcdB against irreversible misfolding and aggregation via a cotranslational folding mechanism |
| 无ECM的患者来源类器官保留了多样化的前列腺癌谱系，并揭示了体外富集的细胞类型 |
Dolgos, R. |
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ECM-free patient-derived organoids preserve diverse prostate cancer lineages and uncover in vitro-enriched cell types |
| RAS/PI3K通路突变使上皮性卵巢癌细胞对PARP/NAMPT抑制剂组合敏感 |
Gruet, M. |
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RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination |
| 阿尔茨海默病APP/PS1雄性和雌性模型以及APPNL-F/NL-F雄性和雌性模型的寿命 |
Roberts, H. |
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Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease |
| 外源硒补充剂可减少镉在稻米中的积累，并恢复稻米中的微量营养素含量。 |
Barman, F. |
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Exogenous selenium supplements reduce cadmium accumulation and restores micronutrient content in rice grains |
| 寄生植物的寄生虫在非传统阶段利用开花途径形成茎衍生的虫瘿。 |
Bessho-Uehara, K. |
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Parasitic-plant parasite utilizes flowering pathways at unconventional stages to form stem-derived galls |
| 肠道细菌衍生的琥珀酸可诱导肠神经系统再生 |
Aydin, B. |
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Gut bacteria-derived succinate induces enteric nervous system regeneration |
| 粘附G蛋白偶联受体ADGRG1促进阿尔茨海默病中保护性小胶质细胞反应 |
Zhu, B. |
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Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer's disease |
| 内侧前额叶皮层中的下边缘区，而非前边缘区，对于复杂的嗅觉记忆任务是必需的。 |
Jun, D. J. |
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The infralimbic, but not the prelimbic cortex is needed for a complex olfactory memory task. |
| 神经肽动态协调分层可塑性机制，使果蝇昼夜节律行为适应变化的环境。 |
Chatterjee, A. |
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Neuropeptide Dynamics Coordinate Layered Plasticity Mechanisms Adapting Drosophila Circadian Behavior to Changing Environment. |
| 整合时间进程分析：来自携带C9orf72、FUS、TARDBP和SOD1突变的ALS患者的iPSCs衍生运动神经元 |
Ma, G. |
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Integrated temporal profiling of iPSCs-derived motor neurons from ALS patients carrying C9orf72, FUS, TARDBP, and SOD1 mutations |
| H3K9me3的表观遗传去抑制通过免疫调节和Vgf诱导缓解了阿尔茨海默病相关病理，并改善了认知功能 |
Fuchs, D.-T. |
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Epigenetic derepression of H3K9me3 mitigates Alzheimer-related pathology and improves cognition via immunomodulation and Vgf induction |
| 青光眼视网膜神经节细胞（RGC）死亡与眼压（IOP）诱导的血视网膜屏障破坏有关。 |
Zhang, C. |
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IOP-induced blood-retinal barrier compromise contributes to RGC death in glaucoma |
| 胶质细胞衍生的通路引导再生视神经轴突向中枢神经系统中线方向生长。 |
Harvey, B. M. |
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Glial cell derived pathway directs regenerating optic nerve axons toward the CNS midline |
| 腹内侧前额叶皮层的独特神经过程介导了注意力负荷的变化和尼古丁促进认知效应的作用 |
Vouillac-Mendoza, C. |
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N/A |
Distinct neuronal processes in the ventromedial prefrontal cortex mediate changes in attention load and nicotine pro-cognitive effects |
| 感觉运动整合增强了温度刺激的处理能力 |
Anderson, L. S. |
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Sensorimotor integration enhances temperature stimulus processing |
| 糖酵解抑制功能性重编程T滤泡辅助细胞并逆转狼疮 |
Elshikha, A. |
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Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus |
| 人类抗糖基化反应是由B细胞的选择驱动的，这些B细胞利用了在生发中心中亲和力成熟的私人抗体基因重排。 |
New, J. S. |
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Human Anti-Glycan Reactivity is Driven by the Selection of B cells Utilizing Private Antibody Gene Rearrangements that are Affinity Maturated in Germinal Centers |
| 一种来自激活的CD4 T细胞的外泌体资源，用于传递促炎信号 |
Jainarayanan, A. K. |
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A resource for extracellular vesicles from activated CD4 T cells that relay pro-inflammatory signals |
| CD4+ T细胞中G蛋白信号调节因子2敲除促进抗炎T细胞，增强排卵和卵母细胞产量 |
Raff, M. |
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Regulator of G-Protein Signaling 2 Knockout in CD4+ T Cells Promotes Anti-Inflammatory T Cells, Enhancing Ovulation, and Oocyte Yield |
| 全球RNA病毒组潜在辅助代谢基因（AMGs）的功能和进化特征 |
Zhao, Y. |
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Functional and evolutionary characterization of potential auxiliary metabolic genes (AMGs) of the global RNA virome |
| 佛罗里达灌木丛中地衣多样性和丰度调查：与烧伤恢复各个时间阶段的关系 |
Holst, M. M. |
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N/A |
Survey of Lichen Diversity and Abundance in a Florida Scrub in Relation to Various Temporal Stages of Burn Recovery |
| NicheFlow：迈向物种分布建模的基础模型 |
Dinnage, R. |
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N/A |
NicheFlow: Towards a foundation model for Species Distribution Modelling |
| 应用基于发生概率的贝叶斯模型评估环境梯度对塞拉多溪流中水生昆虫属种更替的影响 |
Godoy, B. S. |
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Application of a Bayesian model based on probability of occurrence to evaluate the effect of an environmental gradient on the turnover of aquatic insect genera in Cerrado streams |
| 表观基因组的趋同进化在生命之树中招募了DNA修复 |
Monroe, G. |
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Convergent evolution of epigenome recruited DNA repair across the Tree of Life |
| 贝克尔肌营养不良症小鼠表现出骨骼肌中IIa型纤维的部位特异性退化，并伴有毛细血管变化。 |
Miyazaki, D. |
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Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle |
| 稳定选择和适应塑造了秀丽隐杆线虫中顺式和反式基因表达变异 |
Bell, A. D. |
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Stabilizing selection and adaptation shape cis and trans gene expression variation in C. elegans |
| 重建真核生物中RNA结合蛋白的序列特异性 |
Sasse, A. |
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N/A |
Reconstructing the sequence specificities of RNA-binding proteins across eukaryotes |
| 微小RNA 7975直接调控MDTH表达，并在早期动脉粥样硬化的发展中介导内皮细胞的增殖和迁移。 |
Karere, G. |
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Micro-RNA 7975 directly regulates MDTH expression and mediates endothelial cell proliferation and migration in the development of early atherosclerosis |
| 可遗传的非遗传表型在压力反应中富集，作为对冲的一种形式。 |
Grissom, S. |
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Heritable non-genetic phenotypes are enriched for stress responses as a form of bet hedging |
| 通过共价纳米孔检测实现挥发性有机化合物的高分辨率靶向传感 |
McGivern, L. E. |
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N/A |
Targeted, high-resolution sensing of volatile organic compounds by covalent nanopore detection |
| 从牛胚胎干细胞生成培养牛肉 |
Rui, X. |
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N/A |
Generation of cultured beef from bovine embryonic stem cells |
| 快速单细胞基质辅助激光解吸电离成像技术揭示低分子量代谢物的细胞激活标志物 |
Cairns, J. L. |
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Fast Single-Cell MALDI Imaging of Low-Mass Metabolites Reveals Cellular Activation Markers |
| 通过减法蛋白质组学揭示D-丙氨酸-D-丙氨酸连接酶作为伯克霍尔德菌假单胞菌药物靶点的潜力 |
Rahman, S. |
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Subtractive proteomics unravel the potency of D-Alanine-D-Alanine Ligase as the drug target for Burkholderia pseudomallei |
| 利用单细胞RNA测序图谱进行抗体面板的交互设计与验证 |
Watson, M. |
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N/A |
Interactive design and validation of antibody panels using single-cell RNA-seq atlases |
| CELL-Diff：统一扩散建模用于蛋白质序列和显微镜图像 |
Zheng, D. |
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N/A |
CELL-Diff: Unified diffusion modeling for protein sequences and microscopy images |
| Carafe能够为数据非依赖性采集蛋白质组学生成高质量的计算机模拟光谱库。 |
Wen, B. |
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N/A |
Carafe enables high quality in silico spectral library generation for data-independent acquisition proteomics |
| 利用AlphaFold2探索电压门控钠通道的构象及蛋白质-蛋白质相互作用 |
Mateos, D. L. |
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N/A |
Exploring voltage-gated sodium channel conformations and protein-protein interactions using AlphaFold2 |
| HP1a促进染色质流动性并驱动自发异染色质区室化 |
Brennan, L. D. |
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N/A |
HP1a promotes chromatin liquidity and drives spontaneous heterochromatin compartmentalization |
| 渗透型临界阈值控制着免疫蛋白对表面的覆盖 |
Wang, Z. |
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N/A |
A percolation-type criticality threshold controls immune protein coating of surfaces |
| 在转录过程中，染色质缓冲扭转应力 |
Qian, J. |
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N/A |
Chromatin Buffers Torsional Stress During Transcription |
| 基于负载的差异在两个识别相同pMHC的TCR的动态别构效应中 |
Chang-Gonzalez, A. C. |
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N/A |
Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC |
| 在冷冻电子断层扫描技术下观察到的病毒相关流感血凝素在结合唾液酸后形成的簇状结构 |
Huang, Q. Y. |
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N/A |
Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryo-electron tomography |
| 每周吸入沙美特罗西那非，一种选择性β2肾上腺素受体激动剂药物，在体内治疗性地抑制癌症生长并延长生存期。 |
She, X. |
PDF |
N/A |
Weekly inhaled salmeterol xinafoate, a selective β2 adrenergic receptor agonist drug, therapeutically inhibits cancer growth and prolongs survival in vivo |
| 支链氨基酸分解代谢通过mTOR的磷酸化促进卵巢癌细胞增殖 |
Lusk, H. J. |
PDF |
N/A |
Branched-chain amino acid catabolism promotes ovarian cancer cell proliferation via phosphorylation of mTOR |
| 氯硝柳胺前药增强口服生物利用度并靶向肝细胞癌中的Vasorin-TGFβ信号通路 |
Tan, M. |
PDF |
N/A |
Niclosamide Prodrug Enhances Oral Bioavailability and Targets Vasorin-TGFβ Signaling in Hepatocellular Carcinoma |
| 患者来源的ccRCC肿瘤细胞的长读长空间转录组分析揭示了异构体和基因表达的异质性 |
Elshani, M. |
PDF |
N/A |
Long-read Spatial Transcriptomic Profiling of Patient-derived ccRCC Tumoroids Reveals Heterogeneity in Isoform and Gene Expression |
| 肿瘤内CXCL12梯度在乳腺癌中情境化肿瘤细胞侵袭、迁移及免疫抑制 |
Anastasiadou, D. P. |
PDF |
N/A |
Intratumoral CXCL12 Gradients Contextualize Tumor Cell Invasion, Migration and Immune Suppression in Breast Cancer |
| 脂质纳米颗粒共递送紫杉醇和大麻二酚增强对黑色素瘤细胞的细胞毒性 |
de Carvalho, F. V. |
PDF |
N/A |
Co-delivery of Paclitaxel and Cannabidiol in Lipid Nanoparticles Enhances Cytotoxicity Against Melanoma Cells |
| 印度儿童B细胞急性淋巴细胞白血病患者中CD19外显子5-6跳跃现象普遍存在 |
Srivastava, D. |
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N/A |
Widespread Prevalence of CD19 Exon 5-6 Skipping In Indian Pediatric B-cell Acute Lymphoblastic Leukemia Patients |
| 西酞普兰通过调节C5aR1+肿瘤相关巨噬细胞（TAMs）和CD8+ T细胞，展现出依赖免疫的抗肿瘤效应。 |
Dong, F. |
PDF |
N/A |
Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs and CD8+ T cells |
| 速度幅值和周期影响正弦速度变化条件下的步态变异性和步跟随性 |
Motoyama, K. |
PDF |
N/A |
Speed amplitude and period affect gait variability and step followability under sinusoidal speed changing conditions |
| 踝跖屈过程中肌腱微振动强度增加的轨迹：使用潜在曲线模型的纵向数据分析 |
Matsumoto, T. |
PDF |
N/A |
Increase trajectories of tendon micro vibration intensity during ankle plantar flexion: A longitudinal data analysis using latent curve models |
| 生长素（IAA）及其在复杂轮藻（Chara braunii）中的运输作用 |
Kurtovic, K. |
PDF |
N/A |
The role of IAA and its transport in the complex streptophyte algae Chara braunii |
| 黄羽扇豆（Lupinus luteus）对黄羽扇豆炭疽菌（Colletotrichum lupini）的防御机制，涉及TIR-NBS-LRR蛋白、过敏反应及苯丙烷途径 |
Godoy, G. A. |
PDF |
N/A |
Defense mechanisms in Lupinus luteus against Colletotrichum lupini, involving TIR-NBS-LRR protein, hypersensitive response and phenylpropanoid pathways |
| 回顾NIP2同源基因在Rhynchosporium spp.复合体中的进化与功能 |
Darma, R. |
PDF |
N/A |
Revisiting the evolution and function of NIP2 parologs in the Rhynchosporium spp. complex |
| 转移到不同寄主葡萄藤会导致专食性昆虫Daktulosphaira vitifoliae迅速且广泛地转录可塑性变化 |
Collison, W. N. |
PDF |
N/A |
Transfer to different host grapevines causes rapid and widespread transcriptional plasticity in the specialist insect Daktulosphaira vitifoliae |
| 动态多组学与机制建模方法揭示了肾纤维化进展的新机制 |
Tuechler, N. |
PDF |
N/A |
Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression |
| 清醒状态下的蟾蜍大脑活动的慢性记录 |
Shaykevich, D. A. |
PDF |
N/A |
Chronic recording of brain activity in awake toads |
| 长期过度活跃引发培养的海马齿状颗粒细胞亚群中大量且持续的氯离子重新分布 |
Takano, H. |
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N/A |
Prolonged Hyperactivity Elicits Massive and Persistent Chloride Ion Redistribution in Subsets of Cultured Hippocampal Dentate Granule Cells |
| 在正常的产后发育过程中，暗色小胶质细胞大量存在，它们通过吞噬作用和细胞穿孔作用重塑突触，并且依赖于TREM2。 |
Vecchiarelli, H. A. |
PDF |
N/A |
Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2 |
| 用于预测小鼠决策过程中神经回路的真实-网络混合神经网络 |
Ueoka, Y. |
PDF |
N/A |
Real-cyber hybrid neural network for predicting neural circuits in mouse decision-making |
| 青少年亨廷顿病R6/2小鼠模型中的皮层纹状体发育不良 |
Cepeda, C. |
PDF |
N/A |
Corticostriatal Maldevelopment in the R6/2 Mouse Model of Juvenile Huntington Disease |
| 持续注意力期间的警觉性、任务诱发的疲劳和动机：解耦的α波和β波特征的证据 |
Hanzal, S. |
PDF |
N/A |
EEG markers of vigilance, task-induced fatigue and motivation during sustained attention: Evidence for decoupled alpha- and beta-signatures |
| 尾索动物布氏菊海鞘（Botryllus schlosseri）中同种识别受体的遗传和功能多样性 |
Rodriguez-Valbuena, H. |
PDF |
N/A |
Genetic and functional diversity of allorecognition receptors in the urochordate, Botryllus schlosseri |
| 肺上皮祖细胞介导的TGF-β释放调控黏膜卡介苗接种后肺CD8+ TRM细胞的诱导与持久性 |
Blake, J. A. |
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N/A |
Lung epithelial progenitor-mediated release of TGF-β regulates induction and persistence of lung CD8+ TRM cells following mucosal BCG vaccination |
| 肿瘤内预先存在的干细胞样CD8+ T细胞驱动放射治疗诱导的肿瘤控制 |
Koksal, H. |
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N/A |
Pre-existing intratumoral stem-like CD8+ T-cells drive radiotherapy-induced tumor control |
| 在亚热带海洋生态系统的透光层中，寄生和自养主导的原生生物群落的转换与季节性寡营养-中营养梯度相耦合。 |
Avrahami, Y. |
PDF |
N/A |
Switch in parasitic and autotrophic-dominated protist assemblages coupled to seasonal oligotrophic-mesotrophic gradients in the sunlit layer of a subtropical marine ecosystem |
| 一个简单的基于有益和有害相互作用网络的人口动态模型，适用于实证研究。 |
Bimler, M. D. |
PDF |
N/A |
A simple model of population dynamics with beneficial and harmful interaction networks for empirical applications. |
| 雌性推动了果蝇物种交配后生殖特征的进化，但并非通过再交配率来实现。 |
Peckenpaugh, B. |
PDF |
N/A |
Females drive postmating reproductive trait evolution across Drosophila species, but not via remating rate |
| 身体大小和适应度匹配及其对温度可塑性反应的变异性 |
Zygadlo, A. |
PDF |
N/A |
The body size and fitness match and its variability in plastic response to temperature |
| 关岛（马里亚群岛）上两种共存的近缘前礁珊瑚物种的进化基因组学研究。 |
Torrado, H. |
PDF |
N/A |
Evolutionary genomics of two co-occurring congeneric fore reef coral species on Guam (Mariana Islands). |
| cGAS-STING通路是基因组不稳定综合征的内源性修饰因子。 |
Bergman, M. |
PDF |
N/A |
The cGAS-STING pathway is an in vivo modifier of genomic instability syndromes |
| 利用转录组学研究麦二叉蚜与小麦的相互作用 |
Swiegers, H. W. |
PDF |
N/A |
Investigating the Diuraphis noxia-Triticum aestivum interaction using transcriptomics |
| 夜间的人工光照增强了水生碎屑者在捕食风险下的防御行为 |
Rufaida, Z. |
PDF |
N/A |
Artificial light at night enhances the defensive behavior in aquatic shredders under predation risk |
| 硫烯素的发现及其新发现的酰基亚硫酸酯功能团的生物合成 |
Xue, D. |
PDF |
N/A |
Discovery and Biosynthesis of Sulfenicin and Its New-to-Nature Acylsulfenic Acid Functional Group |
| Du-IN-v2：释放向量量化的力量，从颅内神经信号解码认知状态 |
Zheng, H. |
PDF |
N/A |
Du-IN-v2: Unleashing the Power of Vector Quantization for Decoding Cognitive States from Intracranial Neural Signals |
| 从模拟到推断：利用机器学习调整针对特定患者的耳中有限元模型，以实现客观诊断 |
Motallebzadeh, H. |
PDF |
N/A |
From Simulations to Inference: Using Machine Learning to Tune Patient-Specific Finite-Element Models of the Middle Ear Towards Objective Diagnosis |
| 天然保湿因子对皮肤保湿的作用，是一个关于氢键网络的故事。 |
MARTIN, M. |
PDF |
N/A |
Skin hydration by natural moisturizing factors, a story of H-bond networking |
| 一种综合性的空间多组学工作流程，用于统一分析肿瘤组织 |
Kriel, J. |
PDF |
N/A |
An integrative spatial multi-omic workflow for unified analysis of tumor tissue |
| 气溶胶化合物对肺表面活性物质破坏的实验与建模 |
Barlow, H. J. |
PDF |
N/A |
Experiments and modelling of pulmonary surfactant disruption by aerosolised compounds |
| 绘制二氢蝶酸合成酶（DHPS）的可进化性图谱：通过进化和结构分析鉴定新型进化关键子结构 |
Sanyal, D. |
PDF |
N/A |
Mapping DHPS Evolvability: Identification of Novel Evolutionarily Critical Sub-Structure through Evolutionary and Structural Analyses of DHPS |
| 自愿运动减轻了去势抵抗性前列腺癌临床前模型中的肿瘤生长 |
Berger, N. |
PDF |
N/A |
Voluntary Exercise Attenuates Tumor Growth in a Preclinical Model of Castration-Resistant Prostate Cancer |
| 通过FGFR2的消除来拦截导管胰腺癌 |
Tonelli, C. |
PDF |
N/A |
Ductal pancreatic cancer interception by FGFR2 abrogation |
| PRMT5介导的组蛋白甲基化通过MECP2-PTBP1调控选择性剪接，促进乳腺癌缺氧环境下的上皮-间质转化（EMT）。 |
Mutnuru, S. A. |
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N/A |
PRMT5-mediated histone methylation regulates alternative splicing via MECP2-PTBP1 to promote EMT in breast cancer hypoxia |
| Path2Space：一种通过组织病理学推断的空间转录组学AI方法用于癌症生物标志物发现 |
Shulman, E. D. |
PDF |
N/A |
Path2Space: An AI Approach for Cancer Biomarker Discovery Via Histopathology Inferred Spatial Transcriptomics |
| 通过蛋白质组学解析结直肠癌中的硬度驱动变化 |
Cresens, C. |
PDF |
N/A |
Deciphering stiffness-driven changes in colorectal cancer by proteomics |
| 药物蛋白质组学分析鉴定出异常药物作用的分泌标志物 |
Knecht, S. |
PDF |
N/A |
Pharmacoproteomic profiling identifies secreted markers for aberrant drug action |
| CCK1受体在小鼠肠道肠肽酶抑制代谢益处中的作用 |
Hinke, S. A. |
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N/A |
Role of CCK1 receptor in metabolic benefits of intestinal enteropeptidase inhibition in mice |
| 冷冻保护剂合成的可塑性涉及从丙酮酸生产中协调分流。 |
van der Burg, K. R. L. |
PDF |
N/A |
Plasticity in cryoprotectant synthesis involves coordinated shunting away from pyruvate production |
| 探究棉花CMF基因在盐胁迫耐受性中的作用：来自系统发育、表达和功能分析的见解 |
Cui, Y. |
PDF |
N/A |
Exploring the Role of Cotton CMF Genes in Salt Stress Tolerance: Insights from Phylogenetic, Expression, and Functional Analyses |
| 雄性和雌性配子体在冬季相遇：检验日本石栎延迟受精的越冬假说 |
Shagawa, T. |
PDF |
N/A |
Male and female gametophytes meet after winter: Testing the overwintering hypothesis for delayed fertilization in Japanese stone oak |
| 植物表型分化在塑造生菜叶微生物群方面比遗传变异更为重要。 |
Capparotto, A. |
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N/A |
Plant phenotypic differentiation outweighs genetic variation in shaping the lettuce leaf microbiota |
| 桃树TNL RMia基因的鉴定与表达，用于抵抗根结线虫Meloidogyne incognita |
Duval, H. |
PDF |
N/A |
Identification and Expression of the peach TNL RMia genes for the Resistance to the Root-knot Nematode Meloidogyne incognita |
| 干细胞诱导转录因子WUSCHEL的细胞间移动受运输与保留的平衡调控。 |
Fuchs, M. |
PDF |
N/A |
Cell-to-cell mobility of the stem cell inducing WUSCHEL transcription factor is controlled by a balance of transport and retention |
| 气道树的几何分析表明，肺部解剖结构在鲸类动物中进化，以实现爆炸性通气并防止气压伤。 |
Cieri, R. |
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N/A |
Geometric analysis of airway trees shows that lung anatomy evolved to enable explosive ventilation and prevent barotrauma in cetaceans |
| 地下啮齿动物埃洛波斯塔普努斯两个种群的遗传多样性和精细尺度结构 |
Rudyk, A. I. |
PDF |
N/A |
Genetic diversity and fine-scale structure of two populations of a subterranean rodent, Ellobius talpinus |
| 一种深度学习方法，用于检测和可视化单型物种中的性二态性 |
Silva, N. J. |
PDF |
N/A |
A deep learning approach to detect and visualise sexual dimorphism in monomorphic species |
| 微扫视引起的知觉填充延迟与刺激依赖性 |
Levinson, M. |
PDF |
N/A |
Stimulus-dependent delay of perceptual filling-in by microsaccades |
| 长程轴突形态的计算生成 |
Berchet, A. |
PDF |
N/A |
Computational generation of long-range axonal morphologies |
| 巨噬细胞与神经前体细胞和成纤维细胞的相互作用通过Sema4ab控制斑马鱼脊髓损伤后的再生性神经发生 |
Docampo Seara, A. |
PDF |
N/A |
Macrophage crosstalk with neural progenitors and fibroblasts controls regenerative neurogenesis via Sema4ab after spinal cord injury in zebrafish |
| CXCL10/CXCR3信号通路诱导神经衰老和认知障碍 |
Patel, M. |
PDF |
N/A |
CXCL10/CXCR3 Signaling Induces Neural Senescence and Cognitive Impairments |
| 星形胶质细胞Ryk信号在脊髓损伤后协调瘢痕形成和伤口愈合 |
Shen, Z. |
PDF |
N/A |
Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injury |
| 线粒体不存在于执行监视、趋化性和吞噬性吞噬的微胶质突触中。 |
Pietramale, A. N. |
PDF |
N/A |
Mitochondria are absent from microglial processes performing surveillance, chemotaxis, and phagocytic engulfment |
| 通过AP-1调控轴限制先天性Tγδ17细胞的可塑性 |
Parker, M. E. |
PDF |
N/A |
Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis |
| 在C. elegans早期胚胎中，Topoisomerase 2/condensin II轴耗竭后的转录组分析。 |
Belew, M. D. |
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N/A |
Transcriptome analysis in C. elegans early embryos upon depletion of the Topoisomerase 2/condensin II axis. |
| 通过海绵组织采集利用环境DNA宏条形码技术研究大型地中海潟湖的空间和季节性生物多样性变化 |
Corral-Lou, A. |
PDF |
N/A |
Spatial and seasonal biodiversity variation in a large Mediterranean lagoon using environmental DNA metabarcoding through sponge tissue collection |
| 较弱的neuroligin 2-neurexin 1β相互作用通过聚集锚定膜并促进突触生成 |
Boyd, R. |
PDF |
N/A |
Weaker neuroligin 2-neurexin 1β interaction tethers membranes and signal synaptogenesis through clustering |
| 从富含乳糖的废水中生产乳酸：比较反应器配置以最大化转化率和效率的研究 |
Temovska, M. |
PDF |
N/A |
Lactate production from lactose-rich wastewater: A comparative study on reactor configurations to maximize conversion rates and efficiencies |
| AI-QuIC：用于种子扩增实验中自动检测错误折叠蛋白质的机器学习 |
Howey, K. D. |
PDF |
N/A |
AI-QuIC: Machine Learning for Automated Detection of Misfolded Proteins in Seed Amplification Assays |
| a2iHelper：一个用于RNA-Seq数据差异编辑位点分析的Python工具包 |
Ribas, G. T. |
PDF |
N/A |
a2iHelper: a Python toolkit for a differential editing site analysis of RNA-Seq data |
| 通过高浓度聚集调节异源甘氨酸受体功能 |
Yu, H. |
PDF |
N/A |
Modulation of heteromeric glycine receptor function through high concentration clustering |
| Src家族激酶抑制剂药物达沙替尼与糖皮质激素联合使用，对舌鳞状细胞癌显示出协同作用，并能降低MET激酶活性。 |
Hmedat, A. N. A. |
PDF |
N/A |
The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity |
| 临床来源人体组织数字空间分析的严谨性与可重复性 |
Smith, K. D. |
PDF |
N/A |
Rigor and Reproducibility of Digital Spatial Profiling on Clinically Sourced Human Tissues |
| 揭示SH3PXD2B在驱动乳腺癌肺转移的上皮间质转化中的作用 |
Das, S. |
PDF |
N/A |
Unlocking the role of SH3PXD2B in epithelial-to-mesenchymal transition driving Breast Cancer Lung Metastasis |
| 睡眠诱导的血管运动脉动是人类大脑中脑脊液和血脑屏障动态变化的一个驱动因素 |
Väyrynen, T. |
PDF |
N/A |
Sleep-Induced Vasomotor Pulsation is a Driver of Cerebrospinal Fluid and Blood-Brain Barrier Dynamics in the Human Brain |
| 光遗传学诱导的蛋白质聚集与邻近生物素化测定相结合，强烈暗示内溶酶体蛋白在α-突触核蛋白聚集的早期阶段发挥作用。 |
Teixeira, M. |
PDF |
N/A |
The combination of optogenetic-induced protein aggregation and proximity biotinylation assays strongly implicates endolysosomal proteins in the early stages of α-synuclein aggregation |
| 非侵入性光学监测新生儿脑室内出血的临床前模型中的脑血流动力学 |
Jethe, J. V. |
PDF |
N/A |
Noninvasive optical monitoring of cerebral hemodynamics in a preclinical model of neonatal intraventricular hemorrhage |
| 通过全面数据分析进行中风结果预测的基准测试 - NeuralCup 2023 |
Matsulevits, A. |
PDF |
N/A |
Benchmarking Stroke Outcome Prediction through Comprehensive Data Analysis - NeuralCup 2023 |
| KCNQ2/3 K+通道中功能性与轴突始段运输之间的耦合 |
Yoshioka, D. |
PDF |
N/A |
Coupling Between Functionality and Trafficking to the Axon Initial Segment in KCNQ2/3 K+ Channels |
| 神经退行性变小鼠模型和人类疾病中TMEM106B病理的分化与趋同 |
Du, M. |
PDF |
N/A |
Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human Disease |
| 意识的人工智能驱动模型，及其障碍与治疗 |
Toker, D. |
PDF |
N/A |
An AI-Driven Model of Consciousness, Its Disorders, and Their Treatment |
| 偏相关作为绘制人脑连接中功能-结构对应关系的工具 |
Santucci, F. |
PDF |
N/A |
Partial Correlation as a Tool for Mapping Functional-Structural Correspondence in Human Brain Connectivity |
| 接触含有轮胎和道路磨损颗粒（TRWPs）的城市沉积物复合混合物会增加摇蚊（Chironomus riparius）的种系突变率。 |
Rigano, L. |
PDF |
N/A |
Exposure to complex mixtures of urban sediments containing Tyre and Road Wear Particles (TRWPs) increases the germ-line mutation rate in Chironomus riparius |
| 使用机器学习预测天然酵母的表型景观 |
Khaiwal, S. |
PDF |
N/A |
Predicting the natural yeast phenotypic landscape with machine learning |
| 非随机交配和环境传播偏差的简单模型对标准人类遗传学统计方法提出了挑战 |
Border, R. |
PDF |
N/A |
Simple models of non-random mating and environmental transmission bias standard human genetics statistical methods |
| 甲基化时钟并不能预测基因混合个体的年龄或阿尔茨海默病风险 |
Cruz-Gonzalez, S. |
PDF |
N/A |
Methylation Clocks Do Not Predict Age or Alzheimer's Disease Risk Across Genetically Admixed Individuals |
| 小鼠肝脏的昼夜节律异构体图谱 |
Zee, A. |
PDF |
N/A |
The Circadian Isoform Landscape of Mouse Livers |
| 雄性和雌性大鼠在平台介导的回避行为中的泛化和消退 |
Lppez-Moraga, A. |
PDF |
N/A |
Generalization and extinction of platform-mediated avoidance in male and female rats |
| 为什么蝙蝠会飞进洞穴的门？回声定位动物的注意力缺失性失明 |
Finger, N. M. |
PDF |
N/A |
Why do bats fly into cave doors? Inattentional blindness in echolocating animals |
| 初级短跑各阶段影响表现关键因素的演变 |
Oku, K. |
PDF |
N/A |
Evolution of Key Factors Influencing Performance Across Phases in Junior Short Sprints |
| 在新热带慈鲷中，面部颜色作为一种社会信号：测试面部表情假说 |
Satoh, S. |
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N/A |
Facial Coloration as a Social Signal in a Neotropical Cichlid: Testing the Facial Expression Hypothesis |
| 利用体外动态力学加载的小鼠后肢培养，实现临界尺寸缺损的胫前肌（TA）再生 |
Jacho, D. |
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N/A |
Critical-Size Defect Tibialis Anterior (TA) Muscle Regeneration using Ex-Vivo Mice Hindlimbs Culturing under Dynamic Mechanical Loading |
| 解析人类视网膜内的发展异质性，以重建视网膜神经节细胞成熟过程的连续性及特定阶段的内在和外在因素 |
Kriukov, E. |
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N/A |
Unraveling the developmental heterogeneity within the human retina to reconstruct the continuity of retinal ganglion cell maturation and stage-specific intrinsic and extrinsic factors |
| 利用特征架构感知的直系同源分配，追踪植物细胞壁降解酶在整个生命树中的分类分布 |
Tran, V. |
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N/A |
Tracing the taxonomic distribution of plant cell wall degrading enzymes across the tree of life using feature architecture aware orthology assignments |
| 一种用于细菌基因组DNA提取和分析的微流控平台 |
Joesaar, A. |
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N/A |
A microfluidic platform for extraction and analysis of bacterial genomic DNA |
| 人类TRPV4工程产生了一种对超声敏感的驱动器，用于声遗传学 |
Zhao, L. |
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N/A |
Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics |
| 力依赖性重组与机械稳定性：涉及人类受精的Izumo1:Juno复合体的研究 |
Boult, S. |
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N/A |
Force-dependent Reorganization and Mechanostability of the Izumo1:Juno Complex Involved in Human Fertilization |
| 联邦深度学习通过蛋白质组学实现癌症亚型分类 |
Cai, Z. |
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N/A |
Federated deep learning enables cancer subtyping by proteomics |
| 体内CRISPRi筛选鉴定出对皮肤鳞状细胞癌肿瘤生长至关重要的lncRNA组合 |
Kim, G. |
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N/A |
In vivo CRISPRi screen identified lncRNA portfolio crucial for cutaneous squamous cell carcinoma tumor growth |
| TCA循环中的热力学瓶颈导致金黄色葡萄球菌中乙酸的溢出。 |
Shahreen, N. |
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N/A |
A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus |
| 热蛋白质组分析揭示了特定细胞区室中氧化还原变化引起的快速蛋白质组反应 |
Revazian, A. |
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N/A |
Thermal Proteome Profiling reveals rapid proteomic responses to redox changes in specific cellular compartments |
| 开发并验证了一个开源的“手性判断任务”，适用于面对面和在线研究 |
Moreno-Verdu, M. |
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N/A |
Development and validation of an open-source Hand Laterality Judgement Task for in-person and online studies |
| 通过机器学习和转录组整合阐明阿尔茨海默病中淀粉样蛋白-β和tau的神经病理学及分子异质性 |
Zhao, K. |
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N/A |
Elucidating the neuropathological and molecular heterogeneity of amyloid-beta and tau in Alzheimer's disease through machine learning and transcriptomic integration |
| 在稳定的选择-反应关联期间，抽象的选择表征 |
Quinn, K. R. |
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N/A |
Abstract choice representations during stable choice-response associations |
| 艺术中的隐秘拓扑：一扇通往人类感知之窗 |
Dmitriuk, E. |
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N/A |
Art's Hidden Topology: A window into human perception |
| 一种针对α-突触核蛋白聚集物的脑穿梭抗体，用于治疗突触核蛋白病 |
An, S. |
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N/A |
A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies |
| 对免疫组库数据的统计分析显示了微同源性在V(D)J重组中的影响。 |
Russell, M. L. |
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N/A |
Statistical analysis of repertoire data demonstrates the influence of microhomology in V(D)J recombination |
| 探索硫酸乙酰肝素类似物OTR4120的抗纤维化潜力：来自临床前模型的见解 |
Marega, M. |
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N/A |
Exploring the Antifibrotic Potential of the heparan sulfate mimetic OTR4120: Insights from Preclinical Models |
| BBATProt：一种通过可解释深度学习增强特征提取的生物功能预测框架 |
Wang, Y. |
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BBATProt: A Framework Predicting Biological Function with Enhanced Feature Extraction via Explainable Deep Learning |
| BioStructNet：基于结构的网络与迁移学习相结合用于预测生物催化剂功能 |
Wang, X. |
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N/A |
BioStructNet: Structure-Based Network with Transfer Learning for Predicting Biocatalyst Functions |
| 一种用于预测和设计可成药蛋白质的集成方法。 |
Jain, S. |
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N/A |
An ensemble method for predicting and designing of druggable proteins. |
| 在spastin中，一个与疾病相关的主要点突变显著改变了其动力学和变构效应。 |
Kahawatte, S. |
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A major disease-related point mutation in spastin alters dramatically the dynamics and allostery of the motor |
| 磷酸化在两种与膜相关的凝聚态之间切换SARS-CoV-2核衣壳蛋白的状态 |
Favetta, B. |
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Phosphorylation Toggles the SARS-CoV-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States |
| 芳香族氨基酸相互作用强度的交叉：酪氨酸与苯丙氨酸在生物分子凝聚物中的比较 |
De Sancho, D. |
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Crossover in Aromatic Amino Acid Interaction Strength: Tyrosine vs. Phenylalanine in Biomolecular Condensates |
| GBM中GABARAPs的差异表达以p53依赖的方式赋予替莫唑胺敏感性 |
Megha, |
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N/A |
Differential expression of GABARAPs in GBM renders temozolomide sensitivity in a p53-dependent manner |
| SSTR2靶向的肝细胞癌治疗诊断学 |
Momeny, M. |
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SSTR2-targeted theranostics in hepatocellular carcinoma |
| 脱氧神经鞘脂在结肠癌细胞中激活cGAS-STING，并增强肿瘤免疫 |
Saha, S. |
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Deoxysphingolipids activate cGAS-STING in colon cancer cells and enhance tumor immunity |
| 从全基因组层面探究桃金娘HSF基因家族及其在热适应中的功能特征 |
Li, H.-G. |
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A genome-wide-level insight into HSF gene family of Rhodomyrtus tomentosa and the functional characterization of RtHSFA2s genes in thermal adaption |
| 基于代理的拟南芥合子中皮质微管带运动的模拟 |
Nonoyama, T. |
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N/A |
Agent-Based Simulation of Cortical Microtubule Band Movement in the Arabidopsis Zygote |
| 多束神经复合动作电位的模拟分析 |
Tharayil, J. J. |
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Simulation Insights on the Compound Action Potential in Multifascicular Nerves |
| 非侵入性脑刺激对神经纤维瘤1型患者工作记忆任务期间有效连通性的影响 |
Litwinczuk, M. C. |
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Effects of non-invasive brain stimulation on effective connectivity during working memory task in Neurofibromatosis Type 1 patients |
| B细胞表达的酶PexRAP，作为醚脂生物合成中的中间体，促进了抗体反应和生发中心的大小。 |
Cho, S. H. |
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B cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size |
| 纳米材料会引发人体免疫细胞的功能反应。 |
Mittelheisser, V. |
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N/A |
Nanomaterials trigger functional responses in primary human immune cells |
| 腺病毒26型载体疫苗在小鼠中引发的免疫反应的早期时空演变 |
Blass, E. |
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Early spatiotemporal evolution of the immune response elicited by adenovirus serotype 26 vector vaccination in mice |
| 绘制微生物真核生物细胞骨架多样性的图景 |
Mikus, F. |
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N/A |
Charting the landscape of cytoskeletal diversity in microbial eukaryotes |
| 使用时间延迟积分技术的拉曼流式细胞仪 |
Lindley, M. |
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N/A |
Raman flow cytometry using time delay integration |
| 未能再现程序性记忆干扰对年轻和老年成人清醒状态下情景记忆巩固的影响 |
Kamal, L. |
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N/A |
Failure to reproduce the effect of procedural memory interference on wakeful consolidation of episodic memory in younger and older adults |
| 登革病毒2型八面体小病毒样颗粒 |
Johnson, A. |
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N/A |
Octahedral small virus-like particles of dengue virus type 2 |
| 血影蛋白协调皮质肌动蛋白-肌球蛋白的组织和分化，这对功能性上皮屏障至关重要。 |
Soffer, A. |
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N/A |
Spectrin coordinates cortical actomyosin organization and differentiation essential for a functional epithelial barrier |
| 在CRISPR/Cas介导的染色体倒位后，表观遗传状态和基因表达保持稳定。 |
Khosravi, S. |
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N/A |
Epigenetic state and gene expression remain stable after CRISPR/Cas-mediated chromosomal inversions |
| 靶向长链非编码RNA RP11-502I4.3可延缓糖尿病视网膜病变中的血管生成趋势 |
Tan, W. |
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N/A |
Targeting long non-coding RNA RP11-502I4.3 delays the trend of angiogenesis in diabetic retinopathy |
| PD-L1+ 中性粒细胞在非酒精性脂肪肝病中的系统性炎症反应期间介导易感性 |
Barros, C. d. C. O. |
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N/A |
PD-L1+ Neutrophils mediate Susceptibility during Systemic Inflammatory Response in Non-Alcoholic Fatty Liver Disease |
| 反复呈现视觉威胁会驱动先天性恐惧习惯化，并受环境和生理因素的调节。 |
Carroll, J. N. |
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N/A |
Repeated presentation of visual threats drives innate fear habituation and is modulated by environmental and physiological factors |
| mRNA中下游结构元件对核糖体亚基间旋转动力学的影响 |
Shebl, B. |
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The influence of downstream structured elements within mRNA on the dynamics of intersubunit rotation in ribosomes |
| 粗粒度动态模拟细胞骨架微管扭曲 |
Zhu, R. |
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N/A |
Coarse-Grained Dynamic Simulation of Cytoskeletal Microtubule Twist |
| 茉莉酸信号和谷胱甘肽协同调控植物从强光胁迫中恢复 |
Kilic, M. |
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N/A |
Jasmonic acid signaling and glutathione coordinate plant recovery from high light stress |
| HEADING DATE 1基因突变对水稻转录及细胞壁组成的影响 |
Biancucci, M. |
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Impact of mutations in the HEADING DATE 1 gene on transcription and cell wall composition of rice |
| 通过解决GPT不准确响应和基准测试上下文来创建生物医学知识库 |
Darnell, S. S. |
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N/A |
Creating a biomedical knowledge base by addressing GPT inaccurate responses and benchmarking context |
| 大肠杆菌的磷酸丙糖异构酶（TpiA）的结构可塑性 |
Calles, B. |
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N/A |
The structural permissiveness of triosephosphate isomerase (TpiA) of Escherichia coli |
| 大肠杆菌在接近致死酸胁迫下的集体生长动态 |
Segura Munoz, R. R. |
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N/A |
Collective dynamics of Escherichia coli growth under near-lethal acid stress |
| 在长期定殖过程中肠球菌物种间的异质性和代谢多样性 |
Karlsson, P. A. |
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N/A |
Heterogeneity and Metabolic Diversity among Enterococcus Species during Long-term Colonization |
| 丝裂霉素C与低剂量甲硝唑联合使用对艰难梭菌感染及其复发具有协同作用 |
Gong, J.-J. |
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N/A |
Combination of mitomycin C and low-dose metronidazole synergistically against Clostridioides difficile infection and recurrence prevention |
| 马拉色菌（Malassezia furfur）在替代模型宿主秀丽隐杆线虫（Caenorhabditis elegans）中的致病性和肠道屏障破坏能力，部分被鼠李糖乳杆菌（Lacticaseibacillus rhamnosus）所缓解。 |
Kishida, C. |
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N/A |
Pathogenicity and intestinal barrier disruptive ability of Malassezia furfur in an alternative model host Caenorhabditis elegans is partially alleviated by Lacticaseibacillus rhamnosus |
| 通过多聚C结合蛋白实现的铁敏感性RNA调控 |
Forbes, K. |
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N/A |
Iron-sensitive RNA regulation by poly C binding proteins |
| 自闭症患者血液中RNA/DNA杂交谱的分析揭示了mRNA和非编码RNA区域的差异 |
Kianmehr, L. |
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N/A |
Analysis of RNA/DNA Hybrid Profiles in Blood From Autistic Patients Reveals Differences in mRNA and non-coding RNA Regions |
| 囊性纤维化跨膜传导调节因子（CFTR）调节剂对血液蛋白质组的系统性影响 |
Fentker, K. |
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N/A |
Systemic effects of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the blood proteome |
| 核糖体相关质量控制因子TCF25通过结合并特异性地定向受体泛素，使得Listerin介导的新生链泛素化具有K48特异性。 |
Abaeva, I. S. |
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N/A |
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin |
| 通过胆绿素还原酶敲除实现的先进深层组织成像与操控。 |
Kasatkina, L. |
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N/A |
Advanced deep-tissue imaging and manipulation enabled by biliverdin reductase knockout. |
| 结合环境微生物选择的微生物群落进化模型 |
Xiao, Y. |
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N/A |
Models of microbiome evolution incorporating environmental microbial selection |
| 神经元分化过程中依赖于上下文的表观基因组重编程 |
Manelli, V. |
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N/A |
Context-dependent epigenome rewiring during neuronal differentiation |
| 栽培柑橘的超泛基因组揭示了它们在网状进化异域分化阶段的演化特征 |
Droc, G. |
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N/A |
A super-pangenome for cultivated citrus reveals evolutive features during the allopatric phase of their reticulate evolution |
| 通过两种GTPase因子EngA和ObgE介导的单步体外核糖体重构 |
Sato, A. |
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N/A |
Single-step in vitro ribosome reconstitution mediated by two GTPase factors, EngA and ObgE |
| 赖氨酸特异性肽酶的比较分析，以优化蛋白质组学工作流程 |
van der Hoeven, L. R. |
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N/A |
Comparative Analysis of Lysine-Specific Peptidases for Optimizing Proteomics Workflows |
| OfWRKY33结合关键的芳樟醇合酶基因OfTPS7，促进桂花中芳樟醇的合成 |
Xi, W. |
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N/A |
OfWRKY33 binds to the key linalool synthase gene OfTPS7 to promote linalool synthesis in Osmanthus fragrans flowers |
| DNA依赖性蛋白激酶抑制剂PI-103和Samotolisib增强CRISPR/Cas9在人T细胞中的敲入效率 |
Dzafo, E. |
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N/A |
DNA-Dependent Protein Kinase Inhibitors PI-103 and Samotolisib Augment CRISPR/Cas9 Knockin Efficiency in Human T Cells |