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BioRxiv 2024-10-21 Papers

标题 作者 PDF链接 代码仓库 Title
大学考试与心理社会压力:对学生皮质醇节律性的影响 Borghi, F. PDF N/A University Exams and Psychosocial Stress: Effects on Cortisol Rhythmicity in Students
通过木质素复合物持续清除活性氧并改善细胞周围氧合作用,挽救HIF-1α和VEGF水平,从而促进糖尿病伤口的新血管生成和愈合。 Jung, J. P. PDF N/A Sustained ROS Scavenging and Pericellular Oxygenation by Lignin Composites Rescue HIF-1α and VEGF Levels to Improve Diabetic Wound Neovascularization and Healing
血清素调节非快速眼动睡眠期间齿状回的次慢振荡 Turi, G. F. PDF N/A Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep
机器学习预测酶的最适pH值 Gado, J. E. PDF N/A Machine learning prediction of enzyme optimum pH
基于YAP驱动的口腔上皮干细胞恶性重编程的单细胞分辨率研究 Faraji, F. PDF N/A YAP-Driven Oral Epithelial Stem Cell Malignant Reprogramming at Single Cell Resolution
预测亲和力通过同源性(PATH):利用持久同源性进行可解释的结合亲和力预测 Long, Y. PDF N/A Predicting Affinity Through Homology (PATH): Interpretable Binding Affinity Prediction with Persistent Homology
自然杀伤细胞的细胞毒性塑造了B细胞白血病的克隆进化 Buri, M. C. PDF N/A Natural killer cell cytotoxicity shapes the clonal evolution of B cell leukaemia
神经纤毛蛋白-1是NGF和TrkA引发疼痛的共受体。 Peach, C. J. PDF N/A Neuropilin-1 is a co-receptor for NGF and TrkA-evoked pain
一类新型的人类CpG岛启动子,具有灵长类特异性重复序列 Mohan, K. N. PDF N/A A new class of human CpG island promoters with primate-specific repeats
正交化的人类蛋白酶调控分泌信号 Aldrete, C. A. PDF N/A Orthogonalized human protease control of secreted signals
无性生殖的旋口虫Adineta vaga中的跨代染色体修复 Houtain, A. PDF N/A Transgenerational chromosome repair in the asexual bdelloid rotifer Adineta vaga
疟原虫电子传递链中细胞色素c和c1的生物发生 Garcia-Guerrero, A. E. PDF N/A Biogenesis of cytochromes c and c1 in the electron transport chain of malaria parasites
致癌性STIL介导的BRCA1功能丧失导致DNA损伤和中心体扩增 Sanghi, S. PDF N/A Oncogenic STIL-mediated loss of BRCA1 functionality causes DNA damage and centrosome amplification
童年虐待相关的腹内侧前额叶皮层周围神经网增加中微胶质细胞参与的证据 Belliveau, C. PDF N/A Evidence of microglial involvement in the childhood abuse-associated increase in perineuronal nets in the ventromedial prefrontal cortex
通过综合转录组和表观基因组分析揭示癌症驱动基因——Moonlight Nourbakhsh, M. PDF N/A Revealing cancer driver genes through integrative transcriptomic and epigenomic analyses with Moonlight
投射至腹侧CA1区的内梨状神经元是识别记忆的关键节点。 Yamawaki, N. PDF N/A Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory
三部分ATP非依赖性周质(TRAP)转运蛋白结合Neu5Ac的分子决定因素 Goyal, P. PDF N/A Molecular determinants of Neu5Ac binding to tripartite ATP independent periplasmic (TRAP) transporter
墨西哥洞穴鱼在短睡眠状态下表现出升高的DNA损伤,但无衰老迹象 Lloyd, E. PDF N/A Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish
SCREP:通过药理基因组嵌入增强的元预训练和少样本迁移学习实现单细胞药物反应预测 Ge, S. PDF N/A SCREP: Towards Single-Cell Drug Response Prediction by Pharmacogenomic Embedding Enhanced Meta-Pretraining and Few-Shot Transfer Learning
T细胞上PIK3IP1/TrIP的下调受TCR信号强度、PKC以及金属蛋白酶介导的切割调控。 Murter, B. M. PDF N/A Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage
酵母剪接因子Fyv6对3'剪接位点选择的调控 Senn, K. PDF N/A Control of 3' splice site selection by the yeast splicing factor Fyv6
在阿尔茨海默病的小鼠模型中,记忆编码和巩固所依赖的海马功能障碍先于明显的β淀粉样蛋白沉积发生。 Li, H. PDF N/A Impaired hippocampal functions underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of Alzheimer's disease
前生物气体流动环境能够实现等温核酸复制 Schwintek, P. PDF N/A Prebiotic gas flow environment enables isothermal nucleic acid replication
样式偏转由叶序的左右手性和具有镜像花朵的物种中生长素诱导的细胞伸长差异决定。 Robertson, C. PDF N/A Style deflection is determined by the handedness of phyllotaxis and auxin-induced differential cell elongation in a species with mirror-image flowers
嗅觉组合编码支持秀丽隐杆线虫的风险-回报决策 Saad, M. Z. H. PDF N/A Olfactory combinatorial coding supports risk-reward decision making in C. elegans
陆地植物的核基因组和细胞器基因组的进化速率是相互关联的。 Asar, Y. PDF N/A Evolutionary rates of nuclear and organellar genomes are linked in land plants
使用生成对抗网络(GANs)对长基因序列进行潜在生成建模 Szatkownik, A. PDF N/A Latent generative modeling of long genetic sequences with GANs
熵产生限制了基因调控中的信息传递 Gehri, M. PDF N/A Entropy production constrains information throughput in gene regulation
BioLP-bench:评估大型语言模型对生物实验室协议的理解能力 Ivanov, I. PDF N/A BioLP-bench: Measuring understanding of biological lab protocols by large language models
在学习过程中,丘脑核团与皮层网络之间的功能连接发生了渐进性变化。 Jarrett, C. E. PDF N/A Progressive changes in functional connectivity between thalamic nuclei and cortical networks across learning
用于预测转录组结构的长上下文RNA基础模型 Saberi, A. PDF N/A A long context RNA foundation model for predicting transcriptome architecture
大脑活动能够区分同一环境的声学模拟 Matten, V. G. PDF N/A Brain activity discriminates acoustic simulations of the same environment
大脑活动能够区分同一环境的声学模拟 Matten, V. G. PDF N/A Brain activity discriminates acoustic simulations of the same environment
转录依赖的移植染色体在人工细胞中的膨胀 Greiss, F. PDF N/A Transcription-dependent swelling of a transplanted chromosome in an artificial cell
解开睫状层的秘密:睫状糖萼的高分辨率结构与功能 Hoepfner, L. M. PDF N/A Unwrapping the ciliary coat: high-resolution structure and function of the ciliary glycocalyx
使用合成轴突形态生成全脑连接组 Petkantchin, R. PDF N/A Generating brain-wide connectome using synthetic axonal morphologies
PROPERMAB:一种综合框架,利用机器学习进行抗体可开发性的计算机预测 Li, B. PDF N/A PROPERMAB: an integrative framework for in silico prediction of antibody developability using machine learning
冷冻电子断层扫描揭示了黄病毒的复制、出芽和成熟过程的耦合关系。 Dahmane, S. PDF N/A Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation
褐藻门三角褐指藻Seipin同源基因的功能研究揭示了硅藻脂滴生物发生过程的独特特征。 Le Moigne, D. PDF N/A Functional study of Phaeodactylum tricornutum Seipin homolog highlights unique features of lipid droplets biogenesis in diatoms.
单羧酸转运蛋白转运甲状腺素分子机制 Tassinari, M. PDF N/A Molecular mechanism of thyroxine transport by monocarboxylate transporters
开发并验证了一种开源的“手性判断任务”,适用于面对面和在线研究 Moreno-Verdu, M. PDF N/A Development and validation of an open-source Hand Laterality Judgement Task for in-person and online studies
通过解决GPT不准确的回答并进行情境基准测试来创建生物医学知识库 Darnell, S. S. PDF N/A Creating a biomedical knowledge base by addressing GPT inaccurate responses and benchmarking context
在异种Caenorhabditis胚胎中,杂交不亲和性在一细胞阶段显现。 Bloom, J. PDF N/A Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos
ISG15在癌症生物学中的作用:在泛癌背景下系统评估ISG15表达及其分子相互作用 Chatterjee, S. PDF N/A The Role of ISG15 in Cancer Biology: Systematic Evaluation of ISG15 Expression and Its Molecular Interactions in a Pan-Cancer Context
ZNFX1是一种新型主调控因子,参与癌症中表观遗传诱导的病原体模拟和炎症小体信号传导 Stojanovic, L. PDF N/A ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer
生物科学博士在出版方面存在明显的性别和种族/族裔差异模式。 Azurdia, D. E. PDF N/A Distinct patterns of bioscience doctoral publication disparities by gender and race/ethnicity
使用增强型SCas12a检测方法实现高结构RNA的无扩增精确检测 Zhang, J. PDF N/A Precise amplification-free detection of highly structured RNA with an enhanced SCas12a assay
利用GPT-4自动整理泛素-蛋白酶体系统中的E3-底物关系 Zhang, Z. PDF N/A Harnessing GPT-4 for Automated Curation of E3-Substrate Relationships in the Ubiquitin-Proteasome System
体内功能分析与人类Glp1r A316T变异体的结构特征 El Eid, L. PDF N/A In vivo functional profiling and structural characterisation of the human Glp1r A316T variant
通过空间蛋白质组学揭示初级纤毛的内在多样性 Lundberg, E. PDF N/A Intrinsic Diversity in Primary Cilia Revealed Through Spatial Proteomics
依赖于Ca2+的囊泡和非囊泡脂质转移控制低渗质膜扩张 Mu, B. PDF N/A Ca2+-dependent vesicular and non-vesicular lipid transfer controls hypoosmotic plasma membrane expansion
复制依赖性组蛋白(Repli-Histo)标记在活体人类细胞中解析常染色质/异染色质的物理特性。 Minami, K. PDF N/A Replication-dependent histone (Repli-Histo) labeling dissects the physical properties of euchromatin/heterochromatin in living human cells.
使用webKnossos在电子显微镜体积中高效地进行全细胞线粒体映射 Jiang, Y. PDF N/A Efficient cell-wide mapping of mitochondria in electron microscopic volumes using webKnossos
在秀丽隐杆线虫卵母细胞中,减数分裂I和II之间的染色体被一个细胞质分裂囊泡所包围。 El Mossadeq, L. PDF N/A An interkinetic envelope surrounds chromosomes between meiosis I and II in C. elegans oocytes
Sec14L6是一种促进脂滴形成的PS和PI4P转运蛋白。 zhou, t. PDF N/A Sec14L6 is a PS and PI4P transporter that promotes lipid droplet formation
哺乳动物细胞核内厚横纹线状纤维的检测与电子显微镜研究 Mosevitsky, M. I. PDF N/A Detection and electron microscopic study of thick cross-striated linear fibrils in mammalian cell nuclei
在果蝇雄性和雌性的连续同源附肢发育过程中重新连接的基因相互作用 Ridgway, A. M. PDF N/A Rewired gene interactions during development of serially homologous appendages in male and female Drosophila
miR-210基因座缺失破坏细胞稳态;一项综合遗传学研究 Preda, M. B. PDF N/A miR-210 locus deletion disrupts cellular homeostasis; an integrated genetic study
从哔哔声到街道:揭示听觉情境中的感官输入与相关性 Korte, S. PDF N/A From Beeps to Streets: Unveiling Sensory Input and Relevance Across Auditory Contexts
光学模糊对ON和OFF视觉通路的影响不同 Pons, C. PDF N/A Optical blur affects differently ON and OFF visual pathways
岛屿杂交蝴蝶谱系的起源 Boman, J. PDF N/A On the origin of an insular hybrid butterfly lineage
植物相关泛菌中质粒驯化的演化:大规模获得遗传冗余后伴随差异性基因丢失 Picazo, D. R. PDF N/A Evolution of plasmid domestication in plant-associated Pantoea: massive gain of genetic redundancy followed by differential gene loss
大麻二酚(CBD)增强了雌性和雄性小鼠下丘脑-垂体-肾上腺(HPA)轴反应性的生理和行为标志。 Jenkins, B. W. PDF N/A Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic-pituitary-adrenal (HPA) axis responsivity in female and male mice
使用HPM Live μ的Live-HPF CLEM:在每个干草堆中找回所有针。CLEM的最后前沿。 Heiligenstein, X. PDF N/A Live-HPF CLEM using the HPM Live μ: Finding back all needles in every haystack. The last frontier in CLEM
TFAP2C和HNRNPK调控mTOR细胞代谢及朊病毒传播 Sellitto, S. PDF N/A TFAP2C and HNRNPK control mTOR cell metabolism and prion propagation
顶端网格蛋白包被的胞吞凹陷控制上皮微绒毛的生长和大小 Perkins, O. L. PDF N/A Apical clathrin-coated endocytic pits control the growth and size of epithelial microvilli
在T细胞群中出现了协同运动,但在中性粒细胞群中则没有出现。 Wortel, I. M. N. PDF N/A Cooperative motility emerges in crowds of T cells but not neutrophils
主题 使用反向相关法改进听觉表征的特征描述指南 Gezae, G. W. PDF N/A Subject Instructions for Improved Characterization of Auditory Representations Using Reverse Correlation
lucie: 一个改进的用于从UCI机器学习库加载数据集的Python包 Ge, K. PDF N/A lucie: An Improved Python Package for Loading Datasets from the UCI Machine Learning Repository
在使用readmers和hapmers评估牛津纳米孔测序读取错误纠正后的相位切换时 Elbers, J. P. PDF N/A Using readmers and hapmers in assessing phase switching after read error correction of Oxford Nanopore Sequences
解密基本原子相互作用以统一生成分子对接与设计 Peng, X. PDF N/A Decipher Fundamental Atomic Interactions to Unify Generative Molecular Docking and Design
癌症相关脂肪细胞通过FGF21驱动的脂肪分解介导CD8+T细胞功能障碍 Dalangood, S. PDF N/A Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis
烟草烟雾暴露是头颈部癌症中氧化应激反应和免疫功能改变的驱动因素。 Sandulache, V. C. PDF N/A Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer
转录组分析揭示了一群先前未知的Cdkn2a阳性肿瘤相关巨噬细胞,存在于侵袭性脑癌中。 Melo dos Santos, L. S. PDF N/A Transcriptional profiling reveals a previously unknown population of Cdkn2a-positive tumor-associated macrophages in aggressive brain cancer
经皮递送的超可变形阳离子脂质体复合物miR211-5p(UCL-211)稳定了BRAFV600E+黑色素细胞痣 Chhibber, T. PDF N/A Transdermal Delivery of Ultradeformable Cationic Liposomes Complexed with miR211-5p (UCL-211) Stabilizes BRAFV600E+ Melanocytic Nevi
热带气候下叶菜类蔬菜的氮离子组动态 Shenhar, I. PDF N/A Nitrogen ionome dynamics on leafy vegetables in tropical climate
解决光暗转换时非光化学淬灭的非常规信号 Lam, L. PDF N/A Resolving an unconventional non-photochemical quenching signature at the light-to-dark transition
构建脓毒症模型:数据整合揭示了严重铜绿假单胞菌感染的致病机制。 Messina, F. PDF N/A Building a model of sepsis: data integration unravels pathogenic mechanisms in severe P. aeruginosa infections.
朝向生物分子凝聚体中集体相互作用的通用模型 Fuxreiter, M. PDF N/A Towards universal models for collective interactions in biomolecular condensates
多时间尺度神经适应支撑长期肌肉骨骼重塑。 philipp, R. PDF N/A Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization.
新型FKBP12配体MP-004的局部给药可改善视网膜色素变性模型中的视网膜功能和结构。 Lara-Lopez, A. PDF N/A Topical administration of novel FKBP12 ligand MP-004 improves retinal function and structure in retinitis pigmentosa models.
六种腺相关病毒载体血清型在小鼠下丘脑和大脑中的比较分析 Witteveen, I. PDF N/A Comparative analysis of six adeno-associated viral vector serotypes in mouse inferior colliculus and cerebellum
泡沫状小胶质细胞与多发性硬化症进展中的氧化脂质相关 van der Vliet, D. PDF N/A Foamy microglia link oxylipins to disease progression in multiple sclerosis
μ和δ阿片受体通过不同的细胞和分子机制调节前额叶皮层内的抑制作用 Cole, R. H. PDF N/A Mu and Delta Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms
灰葡萄孢菌(Botrytis cinerea)中缺乏植原毒素生产能力的突变体的毒力丧失,可以通过修改接种培养基来恢复。 Qin, S. PDF N/A Loss of virulence of Botrytis cinerea mutants defective in phytotoxin production is restored by modifying inoculation medium
通过刺激血流介导的血管融合,实现Galen静脉畸形血管的逆转 Martin-Valiente, E. PDF N/A Reversal of vein of Galen aneurysmal malformation by stimulation of flow-mediated vessel fusion
模拟欧洲人畜共患脑炎(TBE)风险在时空上的年度变化 Dagostin, F. PDF N/A Modeling the spatio-temporal annual changes in human tick-borne encephalitis (TBE) risk in Europe
模拟气候变暖情景导致独居蜂的羽化时间提前和体重减轻增加,但对越冬存活率没有影响。 Möllmann, J. S. PDF N/A Simulated climate warming scenarios lead to earlier emergence and increased weight loss but have no effect on overwintering survival in solitary bees
树冠的自修剪受功能策略和邻域相互作用的影响。 Kothari, S. PDF N/A Self-pruning in tree crowns is influenced by functional strategies and neighborhood interactions
磷的可用性作为温带生物多样性草本植被中营养限制的主要决定因素 Van Sundert, K. PDF N/A Phosphorus availability as the primary determinant of nutrient limitation in temperate biodiverse herbaceous vegetation
进化宏观生态学:在基于过程、前瞻时间的模拟模型中更明确地纳入系统发育信息 Culshaw, V. PDF N/A Evolutionary macroecology: Incorporating phylogenetic information more explicitly into process-based, forward time, simulation models
广食性微生物捕食者——盘基网柄菌(Dictyostelium discoideum)的猎物吸引力 Shreenidhi, P. M. PDF N/A Prey attraction in a generalist microbial predator, Dictyostelium discoideum
在多维连续空间中建立本地适应的等位基因 Sakamoto, T. PDF N/A Establishment of a locally adaptive allele in multidimensional continuous space
rs2069845多态性与全关节置换术期间IL-6和可溶性IL-6受体水平相关。 Anderson, K. D. PDF N/A Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement
450K和EPIC v2.0阵列之间的时间性和生物性衰老的兼容性和比较分析 De Pourcq, S. PDF N/A Compatibility and comparative analysis of chronological and biological aging between the legacy 450K and the EPIC v2.0 arrays
对从腹泻患者中分离出的多重耐药粘质沙雷菌株IU-BTGE-M-3的比较基因组研究揭示了抗生素耐药性特征 Hossain, M. S. PDF N/A Comparative Genome Study of Multidrug-resistant Serratia marcescens strain IU-BTGE-M-3 Isolated from a Diarrheal Patient Reveals Antibiotic Resistance Profile
表达驱动的遗传依赖性揭示了精准医疗的目标 Elmas, A. PDF N/A Expression-Driven Genetic Dependency Reveals Targets for Precision Medicine
前额叶皮层缺陷是创伤后应激障碍的一个假定易感因素 Nalloor, R. I. PDF N/A Prefrontal Cortical Deficits are a Putative Susceptibility Factor for PTSD
ProtNote:一种用于蛋白质功能注释的多模态方法 Char, S. PDF N/A ProtNote: a multimodal method for protein-function annotation
跑步时缩短飞行时间会减少胫腓骨应变:有限元分析 Khassetarash, A. PDF N/A Reducing flight time during running decreases tibial-fibular strains: a finite element analysis
受物理启发的模型对接配体复合物精度估计器 Bae, B. PDF N/A Physics-inspired accuracy estimator for model-docked ligand complexes
使用惯性矩张量分析对肺癌候选基因进行优先排序 Dwivedi, A. PDF N/A Prioritization of Lung Cancer Candidate Genes using Moment of Inertia Tensor Analysis
组合连锁不平衡与连锁分析(cLDLA):在生物信息学工作流程中实现一种强大的方法,用于识别复杂性状的遗传基础。 Upadhyay, M. PDF N/A Combined Linkage Disequilibrium and Linkage Analysis (cLDLA): implementation of a powerful approach to identify the genetic basis of complex traits in a bioinformatics workflow.
表面活性剂和成膜聚合物对体外测量的肺表面活性剂功能的影响是剂量率依赖性的。 Sengupta, S. PDF N/A The effect of surfactants and film-forming polymers on pulmonary surfactant function measured in vitro is dose-rate dependent
删除率限制乳腺癌和卵巢癌的启动 Houlahan, K. PDF N/A Deletions Rate-Limit Breast and Ovarian Cancer Initiation
IDH突变型胶质瘤起源于携带初始驱动突变的胶质祖细胞。 Park, J. W. PDF N/A IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation
S100a4阳性肺泡巨噬细胞通过促进脂肪酸代谢加速癌前病变不典型腺瘤样增生的进展 Huang, H. PDF N/A S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting fatty acid metabolism
整合素α1β1在小鼠多囊肾病模型中促进间质纤维化 Grenier, C. PDF N/A Integrin alpha1 beta1 promotes interstitial fibrosis in a mouse model of polycystic kidney disease
性激素和季节变化对褪黑素抑制及光警觉反应的影响 Fazlali, F. PDF N/A Sex and seasonal variations in melatonin suppression, and alerting response to light
在固定期间进行的次最大离心训练并不能防止老年或年轻大鼠的串联肌节丢失或机械功能障碍。 Hinks, A. A. PDF N/A Submaximal eccentric training during immobilization does not prevent serial sarcomere loss or impairments in mechanical function in old or young rats
二维猪结肠类器官模型的开发与特性研究:用于肠道生理学与屏障功能的研究 Plenge, M. PDF N/A Development and Characterization of a 2D Porcine Colonic Organoid Model for Studying Intestinal Physiology and Barrier Function
病毒感染和温度对不同温度耐受性甜瓜和西葫芦植株基因响应的综合影响 de Moya-Ruiz, C. PDF N/A The combined effect of viral infection and temperature on the gene response of melon and zucchini plants with different levels of temperature tolerance
蛋白质分解产物作为基于血液的衰老生理标志物:来自狗衰老项目的发现 Harrison, B. R. PDF N/A Protein catabolites as blood-based biomarkers of aging physiology: Findings from the Dog Aging Project
在癌症的网络基础分层分析中整合基因和基因表达数据 Liou, K. PDF N/A Integrating genetic and gene expression data in network-based stratification analysis of cancers
系统性CGRP和PACAP-38对C57BL/6J小鼠运动诱发恶心和平衡行为的影响:一项比较研究 Rahman, S. M. PDF N/A Systemic CGRP and PACAP-38's Effects on Motion-Induced Nausea and Balance Behaviors in C57BL/6J Mice: A Comparison
使用电影刺激模拟人类社会视觉 Santavirta, S. PDF N/A Modelling human social vision with cinematic stimuli
神经元TDP-43聚集在肌萎缩侧索硬化症中驱动小胶质细胞形态变化,先于免疫表型出现。 Swanson, M. E. V. PDF N/A Neuronal TDP-43 aggregation drives changes in microglial morphology prior to immunophenotype in amyotrophic lateral sclerosis
不公平会引发愤怒还是厌恶?基于25年神经影像学的定量神经功能剖析 Gan, X. PDF N/A Does Unfairness Evoke Anger or Disgust? A Quantitative Neurofunctional Dissection Based on 25 Years of Neuroimaging
hnRNP A2/B1剪接变体的细胞质积累在FUS相关的小鼠ALS模型中促成了毒性作用。 Rossi, S. PDF N/A Cytoplasmic accumulation of a splice variant of hnRNP A2/B1 contributes to FUS-associated toxicity in a mouse model of ALS
非致幻的5-羟色胺1B受体对于裸盖菇素在小鼠中的抗抑郁样效应是必要的。 Fleury, S. PDF N/A The non-hallucinogenic serotonin 1B receptor is necessary for the antidepressant-like effects of psilocybin in mice
人类空间导航过程中前额叶Theta和顶叶Alpha振荡事件的单次试验特征 Cuello, M. T. PDF N/A Single trial characterization of frontal Theta and parietal Alpha oscillatory episodes during Spatial Navigation in humans
一种测量骑行期间动机相关事件相关电位(ERP)指标的方法 Renoud-Grappin, R. PDF N/A A Measure of Event-Related Potentials (ERP) Indices of Motivation During Cycling
一项大规模的非注意盲视实验揭示了身体检测的反转效应 Gandolfo, M. PDF N/A A body detection inversion effect revealed by a large-scale inattentional blindness experiment
在斑马鱼幼体中M电流对初级运动神经元兴奋性控制的发展变化 Gaudreau, S. F. PDF N/A Developmental changes in the control of primary motoneuron excitability by the M-current in larval zebrafish
从卵到内脏:新种Sodalis nezarae sp. nov.与南方绿蝽Nezara viridula的共生关系 Rogowska-van der Molen, M. A. PDF N/A From Eggs to Guts: Symbiotic Association of Sodalis nezarae sp. nov. with the Southern Green Shield Bug Nezara viridula
基础EFNA3通过促进氧化磷酸化(OXPHOS),促进乳腺上皮细胞的管腔驱动迁移和癌症转移 Chen, J. PDF N/A Basal EFNA3 Facilitates Luminal-Driving Mammary Epithelial Migration and Cancer Metastasis by Promoting OXPHOS
寨卡病毒和登革病毒通过不同地调控宿主mRNA加工因子来定义其毒力 Scholl, A. PDF N/A Zika and Dengue Viruses Differentially Modulate Host mRNA Processing Factors Defining Its Virulence
基于模型的紫罗兰植物细胞分批培养表现出抗疟和抗癌活性 R, B. PDF N/A Model-based fed-batch cultivation of Viola odorata plant cells exhibiting antimalarial and anticancer activity
体内保护效果:大黄素在达尔顿腹水淋巴瘤诱导的瑞士白化小鼠中的保护作用 Suluvoy, J. K. PDF N/A In vivo Protective Efficacy of Emodin in Swiss Albino Mice Induced with Dalton Ascitic Lymphoma
系统性和局部慢性炎症以及激素分布促进了老年女性乳腺癌易感环境的发展。 Carleton, N. PDF N/A Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women
基于形态学和分子证据,华东地区一种新的荚蒾属(忍冬科)植物——荚蒾属新种 Zhao, L. PDF N/A A new synonym for Viburnum erosum (Viburnaceae) in East China, based on morphological and molecular evidence
孟加拉国退化栖息地中濒危的西白眉长臂猿(Hoolock hoolock)的蠕虫寄生虫感染情况 Kabir, M. T. PDF N/A Helminthic parasite infections of endangered western hoolock gibbons (Hoolock hoolock) in degraded habitats of Bangladesh
雄性特异性sNPF肽能神经回路通过神经-胶质相互作用控制能量平衡以调节交配时长。 Zhang, X. PDF N/A Male-specific sNPF peptidergic circuits control energy balance for mating duration through neuron-glia interactions.
在功能性PET(fPET)-FDG的分析中:基线特征的错误描述可能导致代谢(去)激活的伪影。 Coursey, S. E. PDF N/A On the analysis of functional PET (fPET)-FDG: baseline mischaracterization can introduce artifactual metabolic (de)activations
纹状体中持续性和相位性多巴胺释放的宽带比率测量 Gottschalk, A. PDF N/A Wideband ratiometric measurement of tonic and phasic dopamine release in the striatum
吗啡诱导的痛觉过敏影响小细胞外囊泡miRNA组成和功能 Reddy, D. PDF N/A Morphine-induced hyperalgesia impacts small extracellular vesicle miRNA composition and function
在生态学和进化领域,朝着更全面验证基于机器学习的研究方法迈进 Christensen, C. PDF N/A Moving towards more holistic validation of machine learning-based approaches in ecology and evolution
研究3'UTR中CpG岛DNA甲基化在癌症中的作用 Wilson, C. PDF N/A Investigating the role of CpG island DNA methylation at 3'UTRs in cancer
骨盆环骨折:脊柱骨盆对位是否影响骶骨和腰骨盆固定稳定性? Tripathi, S. PDF N/A Pelvic Ring Fractures: Does Spinopelvic Alignment Affect Sacral and Lumbopelvic Fixation Stability?
DeepVul:一种用于联合预测基因必需性和药物反应的多任务Transformer模型 Jararweh, A. PDF N/A DeepVul: A Multi-Task Transformer Model for Joint Prediction of Gene Essentiality and Drug Response
分子动力学模拟揭示了非天然相互作用在调节孕酮受体从非活性到活性构象转变中的重要性 Hazarika, S. PDF N/A Molecular Dynamics Simulations Reveal the Importance of Non-Native Interactions in Modulating the Inactive to Active Conformational Transition in Progesterone Receptor
ACSS2在乳腺癌脑转移细胞中通过E2F1依赖的方式调控铁死亡 Esquea, E. PDF N/A ACSS2 regulates ferroptosis in an E2F1-dependent manner in breast cancer brain metastatic cells
受体信号放大定量分析:完全激动剂的Kd/EC50比值作为增益参数 Buchwald, P. PDF N/A Quantification of Signal Amplification for Receptors: The Kd/EC50 Ratio of Full Agonists as a Gain Parameter
E3泛素连接酶LIFERING以酰基辅酶A脱氢酶样蛋白IBR3为目标,进行泛素化,并在DNA损伤时协调细胞增殖和细胞死亡。 Kallai, B. PDF N/A LIFERING, an E3 ligase, targets the acyl-CoA dehydrogenase-like protein IBR3, for ubiquitination and coordinates cell proliferation and cell death upon DNA damage
蛋白酶体抑制通过下调HLA-E增强潜伏逆转并提升NK细胞介导的HIV-1感染细胞清除 Laeremans, T. PDF N/A Proteasome inhibition enhances latency reversal and boosts NK cell-mediated elimination of HIV-1 infected cells through HLA-E downregulation
脂肪酸去饱和酶通过连接细胞代谢途径来促进EB病毒感染的B细胞的增殖。 Bonglack, E. N. PDF N/A Fatty acid desaturases link cell metabolism pathways to promote proliferation of Epstein-Barr virus-infected B cells
军团菌科家族的扩展、重构与特征描述 Gabrielli, M. PDF N/A Expansion, restructuring and characterization of the Legionellaceae family
晶体学和核磁共振研究显示,肺炎链球菌LCP蛋白PsrSp中四个长环的动力学对配体特异性具有重要意义。 Sandalova, T. PDF N/A Crystallographic and NMR studies of Streptococcus pneumonia LCP protein PsrSp indicate the importance of dynamics in four long loops for ligand specificity
揭示肠道微生物组网络指纹:一种用于预测黑色素瘤患者免疫治疗反应的深度学习方法。 Sun, J. PDF N/A Unveiling the Gut Microbiome Network Fingerprint: A Deep Learning Approach to Predict Immunotherapy Response in Melanoma Patients.
拟杆菌属和福氏杆菌属原噬菌体多样性、宿主范围及时间稳定性的见解 Hedzet, S. PDF N/A Insights into Diversity, Host-Range, and Temporal Stability of Bacteroides and Phocaeicola Prophages
一种巴斯德氏菌表面的脂蛋白能够结合补体因子I,以促进免疫逃避。 Nguyen, Q. H. PDF N/A A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion.
可遗传的种子携带细菌的优先效应推动了小麦根际微生物群的早期构建 Garrido-Sanz, D. PDF N/A Priority effects of heritable seed-borne bacteria drive early assembly of the wheat rhizosphere microbiome
O特异性抗原的丧失塑造了铜绿假单胞菌在小鼠临床前肺部感染模型中的微生物地理分布 Fraser, H. PDF N/A Loss of O-specific antigen shapes Pseudomonas aeruginosa microbiogeography in murine preclinical pulmonary infection model
一种基因组显著缩小的红假单胞菌菌株保留了其属的核心代谢多功能性。 Oda, Y. PDF N/A A Rhodopseudomonas strain with a substantially smaller genome retains the core metabolic versatility of its genus
禽源硝基呋喃妥因耐药大肠杆菌的动物源性传播潜力 Sealey, J. PDF N/A The Zoonotic Potential of Poultry-Associated Nitrofurantoin-Resistant Escherichia coli
苯并异噁唑-4,7-二酮类化合物的药物化学研究揭示了核糖体小亚基作为特定分枝杆菌翻译准确性靶点的潜力。 Wu, J. PDF N/A Medicinal chemistry of benzoisoxazole-4,7-dione analogues identifies the ribosomal small subunit as a target for specific mycobacterial translational fidelity
通过流式细胞术对水生生态系统进行高通量病毒计数 Bellanger, M. PDF N/A High Throughput Viral Enumeration of Aquatic Ecosystems via Flow Cytometry
铜绿假单胞菌通过代谢交叉喂养支持坏疽性拟杆菌在囊性纤维化肺部多菌种群落中的生存。 El Hafi, B. PDF N/A Pseudomonas aeruginosa supports the survival of Prevotella melaninogenica in a cystic fibrosis lung polymicrobial community through metabolic cross-feeding
P3 定点突变:基于带有3'突出端的引物对的高效方法 Mousavi, N. PDF N/A P3 site-directed mutagenesis: An efficient method based on primer pairs with 3-prime overhangs
通过不育昆虫技术(SIT)在佛罗里达州卡皮塔岛对埃及伊蚊的抑制,2020年至2022年 Morreale, R. PDF N/A SUPPRESSION OF AEDES AEGYPTI BY STERILE INSECT TECHNIQUE (SIT) ON CAPTIVA ISLAND, FLORIDA, USA FROM 2020 TO 2022
自然杀伤细胞和单核细胞的综合转录组分析:推进COVID-19的诊断和治疗策略 Loukman, S. PDF N/A Integrative Transcriptomic Profiling of NK Cells and Monocytes: Advancing Diagnostic and Therapeutic Strategies for COVID-19.
这是SPRTA:在疫情规模下评估系统发育置信度 De Maio, N. PDF N/A This is SPRTA: assessing phylogenetic confidence at pandemic scales
工程设计抗逆基因驱动以实现可持续的疟疾控制:预测、测试及克服目标位点抗性 Morianou, I. PDF N/A Engineering Resilient Gene Drives Towards Sustainable Malaria Control: Predicting, Testing and Overcoming Target Site Resistance
除核糖体外,整个蛋白质翻译机器的自发生物发生 Schwarz-Schilling, M. PDF N/A Autonomous biogenesis of the entire protein translation machinery excluding ribosomes
精确连续尖峰率推断 Stern, M. PDF N/A Exact Continuous Spiking Rate Inference
神经和行为的重现共同反映了叙事事件的提取。 Nau, M. PDF N/A Neural and behavioral reinstatement jointly reflect retrieval of narrative events
DprA招募ComM,以促进革兰氏阴性菌在自然转化过程中进行重组 Dalia, T. N. PDF N/A DprA recruits ComM to facilitate recombination during natural transformation in Gram-negative bacteria
开发和利用表达绿色荧光蛋白的梅毒螺旋体以研究螺旋体与宿主的相互作用及抗体介导的清除机制:扩展梅毒研究工具箱。 Delgado, K. N. PDF N/A Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research.
新鉴定的SpoVAF/FigP复合物:在中等高压下枯草芽孢杆菌孢子萌发中的作用及影响因素 Lyu, F. PDF N/A Newly identified SpoVAF/FigP complex: the role in Bacillus subtilis spore germination at moderate high pressure and influencing factors
A群链球菌的甘露糖磷酸转移酶系统(Man-PTS)影响抗菌活性及特定鼻咽感染的生态位。 Marple, A. C. PDF N/A The Streptococcus pyogenes mannose phosphotransferase system (Man-PTS) influences antimicrobial activity and niche-specific nasopharyngeal infection
一种用于体外发现和体内测试恶性疟原虫疟疾传播阻断药物的一体化流程 Brancucci, N. M. B. PDF N/A An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs
基于单细胞转录组学和多重抗体成像的人类精子发生时空图谱 Hikmet, F. PDF N/A A spatiotemporal atlas of human spermatogenesis based on single-cell transcriptomics and multiplex antibody imaging
禾谷镰刀菌铜胺氧化酶通过将植物防御化合物水解产生的色胺转化为生长素,从而冗余地增加致病性。 Svoboda, T. PDF N/A Fusarium graminearum copper amine-oxidases redundantly increase virulence by converting tryptamine from hydrolyzed plant defense compounds into auxin
走向一个统一的尾噬菌体系统发育框架 Weinheimer, A. R. PDF N/A Towards a unifying phylogenomic framework for tailed phages
使用AlphaFold深入探究Polo样激酶活性的结构调控 Wyatt, M. D. PDF N/A Insights into the Structural Regulation of Polo-Like Kinase Activity using AlphaFold
工程化的Bxb1变体提高了整合酶活性和保真度 Rose, J. PDF N/A Engineered Bxb1 variants improve integrase activity and fidelity
TALE蛋白的计算重设计用于DNA模板化的蛋白质纤维组装 de Haas, R. J. PDF N/A Computational redesign of TALE proteins for DNA-templated assembly of protein fibers
合成生物学中的多功能系统:利用单链DNA信号实现基因激活的精准控制 Ng, B. PDF N/A Multifunctional Systems in Synthetic Biology: Single-Stranded DNA Signaling for Precise Control of Gene Activation
基于显著性的刺激选择在鸟类中脑峡部大细胞部中的叠加抑制性环绕机制 Qian, L. PDF N/A Superimposed inhibitory surrounds underlying Saliency-based Stimulus Selection in avian Midbrain isthmi pars magnocellularis
通过Type V CRISPR-Cas12a系统设计的人类线粒体DNA定向缺失 Nikitchina, N. PDF N/A Targeted deletions in human mitochondrial DNA engineered by Type V CRISPR-Cas12a system
扩展采样方法用于巨冠蝾螈(Triturus cristatus)的环境DNA监测 Harper, L. R. PDF N/A Extending sampling approaches for great crested newt (Triturus cristatus) eDNA monitoring
可持续农业实践的生态和经济效益:来自大面积谷物作物农场试验的证据 Mata, L. PDF N/A The ecological and economic benefits of sustainable agricultural practices: Evidence from on-farm trials in broad-acre grain crops
极地浮游宿主中藻类质体和线粒体的劫持与整合 Rao, A. K. PDF N/A Hijacking and Integration of Algal Plastids andMitochondria in a Polar Planktonic Host
在加拿大萨斯卡通市,从城市到乡村的梯度上,草原驼鹿的空间和时间分布情况 Harris, K. E. PDF N/A Spatial and temporal occurrences of prairie moose across an urban to rural gradient in Saskatoon, Canada
载脂蛋白A-IV多态性Q360H和T347S的结构分析阐明了其抗血栓形成的作用机制 Shoara, A. A. PDF N/A Structural analyses of apolipoprotein A-IV polymorphisms Q360H and T347S elucidate the inhibitory effect against thrombosis
通过神经递质转运蛋白4(NTT4,SLC6A17)转运谷氨酰胺在中枢神经系统兴奋性突触处维持突触前谷氨酸供应 Nicoli, A. L. PDF N/A Glutamine Transport via Neurotransmitter Transporter 4 (NTT4, SLC6A17) Maintains Presynaptic Glutamate Supply at Excitatory Synapses in the Central Nervous System
解聚F-肌动蛋白可加速多能性退出,从而增强干细胞衍生的胰岛分化 Hogrebe, N. J. PDF N/A Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation
集群组装动力学驱动平面细胞极性极化的保真度 Nissen, S. B. PDF N/A Cluster Assembly Dynamics Drive Fidelity of Planar Cell Polarity Polarization