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BioRxiv 2024-10-24 Papers

标题 作者 PDF链接 代码仓库 Title
基于映射的基因组大小估计 Natarajan, S. PDF N/A Mapping-based genome size estimation
恶性疟原虫配子体的数量和比例从急性感染到慢性寄生虫携带状态有所不同,尽管性成熟率保持不变。 van Dijk, H. PDF N/A Number and proportion of P. falciparum gametocytes vary from acute infection to chronic parasite carriage despite unaltered sexual commitment rate
果蝇鞘神经胶质细胞、星形胶质细胞和神经元中的睡眠、进食和代谢稳态动力学 Flores-Valle, A. PDF N/A Dynamics of sleep, feeding, and metabolic homeostasis in Drosophila ensheathing glia, astrocytes, and neurons
非经典端粒酶逆转录酶通过STAT5调控主动脉瓣细胞的成骨性重编程 Cuevas, R. A. PDF N/A Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5
砍伐改变了热带森林的结构,而将其转化为农业用地则降低了生物多样性和生态功能。 Marsh, C. J. PDF N/A Logging alters tropical forest structure, while conversion to agriculture reduces biodiversity and functioning
建模信心判断停止规则中的速度-准确性权衡 Herregods, S. PDF N/A Modelling Speed-Accuracy Tradeoffs in the Stopping Rule for Confidence Judgments
撤回:纳米盘重构的大肠杆菌趋氧受体中的信号转导与激酶调控 Maschmann, Z. A. PDF N/A WITHDRAWN: Signal Transduction and Kinase Control in Nanodisc Reconstituted E. coli Aerotaxis Receptor
深度主动学习在生物医学分割中的鲁棒性 Arikan, M. PDF N/A Deep Active Learning for Robust Biomedical Segmentation
利用新的数据资源来定义新型隐球菌对环境信号的反应 Kang, Y. S. PDF N/A Leveraging a new data resource to define the response of C. neoformans to environmental signals
从单个解剖学上共定位的细胞重建库中提取近似连接组的方法 Manjunatha, K. K. H. PDF N/A A method for extracting an approximated connectome from libraries of single anatomically co-registered cell reconstructions
通过数据驱动的标度律解码朊病毒样结构域的相分离 Maristany, M. J. PDF N/A Decoding Phase Separation of Prion-Like Domains through Data-Driven Scaling Laws
骨形态发生蛋白信号通路中的突变使斑马鱼和人类对乙醇诱导的下颌畸形更为敏感 Klem, J. R. PDF N/A Mutation in the Bone Morphogenetic Protein signaling pathway sensitize zebrafish and humans to ethanol-induced jaw malformations
原位近原子分辨率下的核糖体动态快照:全面洞察真核延伸循环 Zhang, X. PDF N/A Snapshots of ribosome dynamics near atomic-resolution in situ: full insight into the eukaryotic elongation cycle
ATR通过从头胆固醇合成促进mTORC1活性。 Tangudu, N. K. PDF N/A ATR promotes mTORC1 activity via de novo cholesterol synthesis
可修改的临床牙科印模方法,用于从脊椎动物获取全口及详细的牙齿特征 Wibisana, J. N. PDF N/A Modifiable clinical dental impression methods to obtain whole-mouth and detailed dental traits from vertebrates
KRAB锌指基因和转座元件的调控网络在人类大脑进化和疾病过程中发生了变化 Chen, Y.-C. PDF N/A Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease
山松甲虫在不同寄主抗性的森林中蔓延 Brush, M. PDF N/A Mountain pine beetle spread in forests with varying host resistance
微生介导入侵的统一理论 Martignoni, M. M. PDF N/A Toward a unified theory of microbially-mediated invasion
成本效益权衡在练习过程中调节了基于规则到基于记忆的处理转变 Yang, G. PDF N/A Cost-benefit Tradeoff Mediates the Rule- to Memory-based Processing Transition during Practice
可泛化的情感投入和脱离神经模型 Nanni Zepeda, M. PDF N/A Generalizable Neural Models of Emotional Engagement and Disengagement
SEGUID v2:扩展SEGUID校验和以适用于环状、线性、单链和双链生物序列 Pereira, H. PDF N/A SEGUID v2: Extending SEGUID checksums for circular, linear, single- and double-stranded biological sequences
mm2-gb:用于长读DNA比对的GPU加速Minimap2 Dong, J. PDF N/A mm2-gb: GPU Accelerated Minimap2 for Long Read DNA Mapping
作为进化驱动力的可移动元件在仙人掌嗜好果蝇物种宿主转移中的作用 Oliveira, D. S. d. PDF N/A Transposable elements as evolutionary driving force to host shift in cactophilic Drosophila species
在V1皮层柱模型中,细胞类型的特定放电模式取决于前馈和反馈驱动状态。 Moreni, G. PDF N/A Cell type specific firing patterns in a V1 cortical column model depend on feedforward and feedback-driven states
氨基酸招募进入遗传密码的顺序由最后普遍共同祖先的蛋白质域解析 Wehbi, S. PDF N/A Order of amino acid recruitment into the genetic code resolved by Last Universal Common Ancestor's protein domains
5-HT1A受体在斑马鱼对潜在威胁的反应及社交性中的作用 de Sousa, L. V. X. B. PDF N/A Roles of the 5-HT1A receptor in zebrafish responses to potential threat and in sociality
羽纹硅藻中细胞大小感知和接合型分化的分子指纹 Belisova, D. PDF N/A Molecular fingerprints of cell size sensing and mating type differentiation in pennate diatoms
栖息地破碎化介导了长期气候驱动下鸟类喜温性变化的机制 Liu, J. PDF N/A Habitat fragmentation mediates the mechanisms underlying long-term climate-driven thermophilization in birds
铁死亡抑制对抗代谢紊乱并改善肺动脉环扎猪的心脏功能 Kazmirczak, F. PDF N/A Ferroptosis Inhibition Combats Metabolic Derangements and Improves Cardiac Function in Pulmonary Artery Banded Pigs
发现荧光:利用社区科学记录新型生物荧光现象,并促进社区参与科学活动 Burke, H. PDF N/A Finding Fluorescence: Utilizing community science to document novel biofluorescence occurrences and encourage community engagement in science
通过神经反馈实现对远程海马表征的闭环调制 Coulter, M. E. PDF N/A Closed-loop modulation of remote hippocampal representations with neurofeedback
在阿尔茨海默病的小鼠模型中,微生物群以性别特异性的方式影响免疫反应。 Bostick, J. W. PDF N/A The microbiome shapes immunity in a sex-specific manner in mouse models of Alzheimer's disease
阿尔茨海默病相关保护性变异Plcg2-P522R以性别二态性方式调节外周巨噬细胞功能 Staley, H. A. PDF N/A Alzheimer's disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner
针对动物体内特定基因组DNA序列的靶向诱变,以生成体内变异文库 Falo-Sanjuan, J. PDF N/A Targeted mutagenesis of specific genomic DNA sequences in animals for the in vivo generation of variant libraries
17α-雌二醇治疗对内分泌系统的影响通过下丘脑单核转录组测序揭示 Li, L. PDF N/A The effects of 17α-estradiol treatment on endocrine system revealed by single-nucleus transcriptomic sequencing of hypothalamus
AIVE:通过全面分析准确预测SARS-CoV-2感染性 Park, J. PDF N/A AIVE: accurate predictions of SARS-CoV-2 infectivity from comprehensive analysis
小鼠大脑的左右脑神经解剖学广泛不对称性 Silberfeld, A. PDF N/A Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain
西欧沿海沙丘中植物相关无脊椎动物群落结构的驱动因素 Van De Walle, R. PDF N/A Drivers of plant-associated invertebrate community structure in West-European coastal dunes
全组织成像:亚微米分辨率下的细胞边界成像用于自动细胞分割——在外胚层附属物上皮弯曲中的应用 Norris, S. C. P. PDF N/A Whole Tissue Imaging of Cellular Boundaries at Sub-Micron Resolutions for Automatic Cell Segmentation: Applications in Epithelial Bending of Ectodermal Appendages
不平衡基因组中RNA m6A甲基化的动态变化及其调控作用 Zhang, S. PDF N/A Dynamics and Regulatory Roles of RNA m6A Methylation in Unbalanced Genomes
胶质细胞调控嗅觉关键期中的经验依赖性可塑性 Leier, H. C. PDF N/A Glia control experience-dependent plasticity in an olfactory critical period
人类目标导向动作的准备涉及皮质脊髓神经计算的混合。 Wadsley, C. G. PDF N/A Goal-directed action preparation in humans entails a mixture of corticospinal neural computations
一种能够穿过血脑屏障的神经肽-神经降压素偶联物,在小鼠癫痫持续状态后诱导了具有抗惊厥、神经保护和抗炎特性的药理性低体温。 Ferhat, L. PDF N/A A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice
运动序列特异性学习诱导的皮层脊髓可塑性偏向于感觉运动μ节律的峰值相位 Suresh, T. PDF N/A Motor sequence-specific learning-induced corticospinal plasticity is biased towards sensorimotor mu rhythm peak phases
自我关联通过自动优先处理社会显著信号来增强早期注意力选择 Scheller, M. PDF N/A Self-association enhances early attentional selection through automatic prioritization of socially salient signals
基于新型扩增子的方法用于HIV-1 M组重组形式近全长基因组(NFLG)测序 Moscona, R. PDF N/A Novel Amplicons based Method for Near-Full-Length Genome (NFLG) Sequencing of HIV-1 Group M Recombinant Forms
一种基于原则的区域间皮层网络社区检测方法 Armas, J. S. M. PDF N/A A principled approach to community detection in interareal cortical networks
使用泛基因组进行基因型序列解析的拷贝数变异,揭示了重复基因的同源特异性全球多样性及表达分化 Ma, W. PDF N/A Genotyping sequence-resolved copy-number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes
通过多模态蛋白质-配体对比学习提升挑战性目标筛选 Wang, Z. PDF N/A Enhancing Challenging Target Screening via Multimodal Protein-Ligand Contrastive Learning
神经扫描:通过解剖网络的时空整合探索神经发育 Koonce, N. L. PDF N/A NeuroSCAN: Exploring Neurodevelopment via Spatiotemporal Collation of Anatomical Networks
UBE3C和NRF1依赖的蛋白酶体途径对急性蛋白质聚集物周转的时间控制 Hickey, K. L. PDF N/A Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways
灵长类尾状核在多模态决策中的独特神经结构及其关键作用 ZENG, Z. PDF N/A Distinct neural manifolds and critical roles of primate caudate nucleus in multimodal decision-making
SARS-CoV-2主蛋白酶活性位点环的构象空间由配体结合和蛋白质间别构效应决定。 Lee, E. PDF N/A The Conformational Space of the SARS-CoV-2 Main Protease Active Site Loops is Determined by Ligand Binding and Interprotomer Allostery
在发声新颖性的进化过程中,运动皮层投射的选择性扩展 Isko, E. C. PDF N/A Selective expansion of motor cortical projections in the evolution of vocal novelty
免疫样糖识别与横向获得性糖加工协同调控微生物内共生中的宿主控制 Jenkins, B. H. PDF N/A Immune-like glycan-sensing and horizontally-acquired glycan-processing orchestrate host control in a microbial endosymbiosis
制造感知的生成模型架构能够实现生物序列的设计和合成,达到千万亿次规模 Weinstein, E. N. PDF N/A Manufacturing-Aware Generative Model Architectures Enable Biological Sequence Design and Synthesis at Petascale
解析铜绿假单胞菌对亚胺培南耐药性的蛋白质组学图谱:临床与对照菌株的比较研究 Eidsaa, M. PDF N/A Unravelling the Proteomic Landscape of Imipenem Resistance in Pseudomonas aeruginosa: A Comparative Investigation between Clinical and Control Strains
母体脂联素恢复了暴露于宫内母体肥胖的成年后代阻力血管中的胆碱能血管舒张 Murphy, M. PDF N/A Maternal adiponectin restores cholinergic vasodilation in resistance vessels from adult offspring exposed to maternal obesity in utero
反复的基因渐渗和地理分层塑造了新热带地区的酿酒酵母(Saccharomyces cerevisiae) Avelar-Rivas, J. A. PDF N/A Recurrent introgression and geographical stratification shape Saccharomyces cerevisiae in the Neotropics
尾洛辛介导的软腐欧氏杆菌属细菌间的相互作用 Borowicz, M. PDF N/A Tailocin-mediated interactions in Soft Rot Pectobacteriaceae
一项简单的措施可减少高脂肪饮食摄入并降低小鼠肥胖率 Barrett, M. R. PDF N/A A simple action reduces high fat diet intake and obesity in mice
对古老干燥样本中的RNA进行测序,揭示了过去的病毒群以及长期存活的RNA的特性。 Keene, A. H. PDF N/A Sequencing RNA from old, dried specimens reveals past viromes and properties of long-surviving RNA
生物膜流丝的应力硬化行为 Savorana, G. PDF N/A Stress-hardening behaviour of biofilm streamers
重新审视雄蚊不吸血的范式 Bozic, J. PDF N/A Revisiting the paradigm of anhematophagy in male mosquitoes
纳米抗体表位预测中的AI驱动方法:我们是否已经到达? Eshak, F. PDF N/A AI driven approaches in Nanobody Epitope Prediction: Are We There Yet?
探索用于抗体序列设计排名的对数似然评分 Ucar, T. PDF N/A Exploring Log-Likelihood Scores for Ranking Antibody Sequence Designs
焦虑/抑郁的个体在认知冲突编码过程中表现出前额叶-颞叶同步性中断。 Shekara, A. PDF N/A Anxious/depressed individuals exhibit disrupted frontotemporal synchrony during cognitive conflict encoding
Dnajc3(HSP40)调节小鼠视神经的轴突再生 Wang, J. PDF N/A Dnajc3 (HSP40) Modulates Axon Regeneration in the Mouse Optic Nerve
通过基因集嵌入揭示潜在的生物功能关联 Huang, Y. PDF N/A Uncovering Latent Biological Function Associations through Gene Set Embeddings
保留隐藏的层次结构:用于增强基因组序列分析的庞加莱距离 Ali, S. PDF N/A Preserving Hidden Hierarchical Structure: Poincare Distance for Enhanced Genomic Sequence Analysis
半监督组学因子分析(SOFA)从多组学数据中的潜在因子中分离出已知的变异来源。 Capraz, T. PDF N/A Semi-supervised Omics Factor Analysis (SOFA) disentangles known sources of variation from latent factors in multi-omics data
增强小鼠发声的皮层运动神经元投射 Boyd, J. L. PDF N/A Enhancing cortico-motoneuronal projections for vocalization in mice
有丝分裂纺锤体的方向和动力学通过NuMA定位在各向异性组织拉伸的精细调节下得以实现。 Tarannum, N. PDF N/A Mitotic spindle orientation and dynamics are fine-tuned by anisotropic tissue stretch via NuMA localisation
青光眼视网膜神经节细胞(RGC)死亡与眼压(IOP)诱导的血视网膜屏障破坏有关。 Zhang, C. PDF N/A IOP-induced blood-retinal barrier compromise contributes to RGC death in glaucoma
B细胞表达的酶PexRAP,作为醚脂生物合成中的中间体,促进了抗体反应和生发中心的大小。 Cho, S. H. PDF N/A B cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size
在异种Caenorhabditis胚胎的单细胞阶段出现了杂交不亲和性。 Bloom, J. PDF N/A Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos
尖峰皮层及其连接网络中的结构妥协 Sahlas, E. PDF N/A Structural compromise in spiking cortex and connected networks
地球上最古老生物潘多中的体细胞突变镶嵌图 Pineau, R. PDF N/A Mosaic of Somatic Mutations in Earth's Oldest Living Organism, Pando
Rag2Mol:基于检索增强生成的结构化药物设计 Zhang, P.-D. PDF N/A Rag2Mol: Structure-based drug design based on Retrieval Augmented Generation
基底神经节输出的计算瓶颈(以及应对方法) Humphries, M. D. PDF N/A The computational bottleneck of basal ganglia output (and what to do about it)
α-突触核蛋白株系动力学与帕金森病中的认知转变相关 Gadhave, K. PDF N/A α-Synuclein Strain Dynamics Correlate with Cognitive Shifts in Parkinson's Disease
蚊虫调查揭示了马拉维蚊子在桑给巴尔市繁殖地点的偏好。 Hill, K. PDF N/A Larval surveys reveal breeding site preferences of malaria vector Anopheles spp. in Zanzibar City
丹曲林对携带严重恶性高热突变Y522S的雷诺定受体1的抑制作用通过冷冻电镜可视化 Iyer, K. A. PDF N/A Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM
PACT通过防止内源性双链RNA异常激活PKR,而无需隔离。 Ahmad, S. PDF N/A PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration
依赖于HuR的RyR2表达有助于棕色脂肪细胞中钙介导的产热作用 Guarnieri, A. R. PDF N/A HuR-dependent expression of RyR2 contributes to calcium-mediated thermogenesis in brown adipocytes
入侵太阳珊瑚(Tubastrea spp.)在里约热内卢海岸的模拟幼虫扩散:亚中尺度丝状体在离岸运输和连通性中的作用 Calado, L. PDF N/A Simulated larvae dispersion of the invasive sun-coral (Tubastrea spp.) along Rio de Janeiro's coast: the role of submesoscale filaments on offshore transport and connectivity
在早更新世到中更新世过渡期间,人类经历了严重瓶颈的证据不足。 Durvasula, A. PDF N/A Insufficient evidence for a severe bottleneck in humans during the Early to Middle Pleistocene transition
利用自然序列变异在胚胎发生过程中情境化转录因子结合 Sigalova, O. M. PDF N/A Contextualising transcription factor binding during embryogenesis using natural sequence variation
低保真度DNA聚合酶IV加速了铜绿假单胞菌的基因组进化 Castell, S. PDF N/A Low fidelity DNA polymerase IV accelerates genome evolution in Pseudomonas aeruginosa
用于研究RNA结构的生物正交环丙烯酮 Chen, S. PDF N/A Bioorthogonal cyclopropenones for investigating RNA structure
人类肠道共生菌阿利斯蒂普斯·蒂莫内西斯(Alistipes timonensis)能够调节宿主的脂质组,并向宿主传递抗炎的外膜囊泡,从而在白介素10缺陷的小鼠模型中抑制结肠炎。 Older, E. A. PDF N/A Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model
II型-B CRISPR-Cas增强特异性的机制 Hibshman, G. N. PDF N/A Mechanism of type II-B CRISPR-Cas enhanced specificity
对于植物来说真实的情况,对于三角褐指藻(Phaeodactylum tricornutum)可能并不适用:香草兰(Vanilla planifolia)的香草醛合成酶(VpVAN)被靶向到硅藻的四个亚细胞区室中的情况。 Diaz-Garza, A. M. PDF N/A What is true for plants may not be true for Phaeodactylum tricornutum: The case of Vanilla planifolia vanillin synthase (VpVAN) targeted to four subcellular compartments of the diatom.
裸盖菇素减少了SAPAP3基因敲除小鼠模型中强迫行为的梳理行为 Gattuso, J. J. PDF N/A Psilocybin Reduces Grooming in the SAPAP3 Knockout Mouse Model of Compulsive Behaviour
语言网络历久弥新:老年人脑中保留的选择性、侧化及网络内功能同步性 Billot, A. PDF N/A The language network ages well: Preserved selectivity, lateralization, and within-network functional synchronization in older brains
鉴定细胞周期蛋白L1作为调控乙型肝炎病毒复制的宿主因子 Owino, C. O. PDF N/A Identification of Cyclin L1 as a host factor regulating Hepatitis B Virus replication
结核菌噬菌体毒力比较研究 Rubino, I. PDF N/A Comparative study on the virulence of mycobacteriophages
比较基因组分析揭示了水体中拉氏菌属(Ralstonia spp.)致病性的降低 Liu, g. PDF N/A Comparative genomic analysis reveals reduced pathogenicity of Ralstonia spp. in water
SETD2促进PAF1C与延伸中的RNA聚合酶II的相互作用,并且对于神经分化是必需的。 Ambrosi, C. PDF N/A SETD2 promotes PAF1C interactions with the elongating RNA Pol II and is required for neuronal differentiation
RTL4是一种与自闭症谱系障碍相关的逆转录病毒衍生基因,是一种微胶质细胞基因,在出生后的大脑中对去甲肾上腺素产生反应。 Ishino, F. PDF N/A RTL4, a retrovirus-derived gene implicated in autism spectrum disorder, is a microglial gene that responds to noradrenaline in the postnatal brain
RTL4是一种与自闭症谱系障碍相关的逆转录病毒衍生基因,是一种对出生后大脑中的去甲肾上腺素产生反应的微胶质细胞基因。 Ishino, F. PDF N/A RTL4, a retrovirus-derived gene implicated in autism spectrum disorder, is a microglial gene that responds to noradrenaline in the postnatal brain
四棘刺鱼(Apeltes quadracus)具有XY性染色体系统,其X和Y染色体上均存在多态性倒位。 Liu, Z. PDF N/A The fourspine stickleback (Apeltes quadracus) has an XY sex chromosome system with polymorphic inversions on both X and Y chromosomes
使用分层变压器进行机制性的基因型-表型转换 Lee, I. PDF N/A Mechanistic genotype-phenotype translation using hierarchical transformers
LUNAR:一种利用综合基因组和临床数据预测胶质瘤复发的深度学习模型 Patricoski-Chavez, J. A. PDF N/A LUNAR: A Deep Learning Model to Predict Glioma Recurrence Using Integrated Genomic and Clinical Data
进化中新出现的脑结构的可变存在与特质冲动性相关 Willbrand, E. H. PDF N/A Variable Presence of an Evolutionarily New Brain Structure is Related to Trait Impulsivity
表示相似性分析、中心核对齐和典型相关分析之间的等价性 Williams, A. H. PDF N/A Equivalence between representational similarity analysis, centered kernel alignment, and canonical correlations analysis
BBSome亚基耗竭通过TGF-β信号通路改变受体内吞作用并促进上皮-间质转化 Solarat, C. PDF N/A Depletion of BBSome Subunits Alters Receptor Endocytosis and Promotes EMT via TGF-β Signaling
尿液生化生态学揭示了微生物组-代谢物相互作用和复发性尿路感染的代谢标志物 Neugent, M. L. PDF N/A Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection
毒力因子与信号分子的相互作用:白蛋白和钙介导的支气管败血博德特菌生物膜调控 Mugni, S. L. PDF N/A Interplay of Virulence Factors and Signaling Molecules: Albumin and Calcium-Mediated Biofilm Regulation in Bordetella bronchiseptica
丰富的环境需要对海马旁神经网进行重塑,以在阿尔茨海默病小鼠模型中触发记忆改善 Bouisset, G. PDF N/A Enriched environment requires remodeling of hippocampal perineuronal nets to trigger memory improvement in Alzheimer's mouse model
冲动的青少年在解码面部表情情绪时表现出处理效率低下和决策阈值较低的特点。 Schreiber, A. M. PDF N/A Impulsive adolescents exhibit inefficient processing and a low decision threshold when decoding facial expressions of emotions
新的治疗组合,以增强针对胶质母细胞瘤细胞中EGFR的抗体和核酸适体的内吞作用 Cruz Da Silva, E. PDF N/A New therapeutic combination to enhance endocytosis of antibodies and nucleic-acid aptamers targeting EGFR in glioblastoma cells
NINJ1在溶细胞死亡期间通过钙驱动的质膜脂质混杂而被激活。 Borges, J. P. PDF N/A NINJ1 is activated by calcium-driven plasma membrane lipid scrambling during lytic cell death
Nance-Horan综合征样1通过与内皮素和Ena/VASP蛋白相互作用,促进快速内皮素介导的内吞作用。 Cope, J. F. W. PDF N/A Nance-Horan Syndrome-like 1 interacts with endophilin and Ena/VASP proteins to promote fast endophilin-mediated endocytosis.
Nance-Horan综合征样1与内菲林和Ena/VASP蛋白相互作用,促进快速内菲林介导的内吞作用。 Cope, J. F. W. PDF N/A Nance-Horan Syndrome-like 1 interacts with endophilin and Ena/VASP proteins to promote fast endophilin-mediated endocytosis.
极端干旱期间的进化救援 Anstett, D. N. PDF N/A Evolutionary rescue during extreme drought
Pipeasm:一种用于自动化大型染色体规模基因组组装和评估的工具 Silva, B. M. PDF N/A Pipeasm: a tool for automated large chromosome-scale genome assembly and evaluation
E3泛素连接酶NEDD4L通过降解PRMT5来抑制AKT/mTOR信号通路,从而防止结直肠癌肝转移。 Dong, Z. PDF N/A The E3 ligase NEDD4L prevents colorectal cancer liver metastasis via degradation of PRMT5 to inhibit the AKT/mTOR signaling pathway
身体不满塑造了时间感知与内感受的相互作用 Rusinova, A. PDF N/A Body dissatisfaction shapes time perception and interoception interplay
基因变异的相互作用激活酵母中潜在的代谢途径 Sasikumar, S. PDF N/A Interaction of Genetic Variants Activates Latent Metabolic Pathways in Yeast
组织适应性Tregs利用炎症信号促进肠道从治疗相关损伤中修复 Fischer, J. C. PDF N/A Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury
鸟类沿经线方向迁徙,以响应青藏高原隆升所导致的亚洲季风效应。 Zhang, W. PDF N/A Birds migrate longitudinally in response to the resultant Asian monsoons of the Qinghai-Tibet Plateau uplift
快速寿命的脊椎动物宿主具有更高的蚊媒寄生虫传播潜力 Dahlin, K. J.- M. PDF N/A Fast-lived Vertebrate Hosts Exhibit Higher Potential for Mosquito-borne Parasite Transmission
果蝇翅膀上的性选择目标 De Lisle, S. P. PDF N/A Targets of sexual selection on the Drosophila wing
病原体启动改变了野生鸣禽宿主的传播潜力和传播能力预测因子 Leon, A. E. PDF N/A Pathogen priming alters host transmission potential and predictors of transmissibility in a wild songbird species
双trxG/PcG蛋白ULTRAPETALA1调控H3K27me3,并直接增强POLYCOMB抑制复合物2的活性,以实现精细调控的生殖转换 Geshkovski, V. PDF N/A The dual trxG/PcG protein ULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions
Bur1驱动的G1到S期转变诱导了酵母检查点突变体的羟基脲敏感性 da Silva, S. C. R. PDF N/A Bur1-driven G1-to-S phase transition induces hydroxyurea sensitivity in yeast checkpoint mutants
Hippo-vgll3信号可能通过不同的脂肪动态影响大西洋鲑鱼成熟年龄的性别差异。 Ahi, E. P. PDF N/A Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics
许多实验室血吸虫种群中保留了丰富的遗传变异。 Jutzeler, K. S. PDF N/A Abundant genetic variation is retained in many laboratory schistosome populations
查尔酮异构酶的自然变异定义了控制黑杨种群间生长变异的主要位点 Durufle, H. PDF N/A Natural variation in chalcone isomerase defines a major locus controlling growth variation between Populus nigra populations
香烟烟雾成分对-苯醌对人红细胞结构与功能的影响 Yadav, N. PDF N/A Effect of p-benzoquinone, a cigarette smoke-derived component, on the architecture and function of human RBC
工程化细菌微室壳中的受控酶货物装载 Tefft, N. M. PDF N/A Controlled enzyme cargo loading in engineered bacterial microcompartment shells
麦角固醇和7-脱氢胆固醇及其内过氧化物的比较研究:生成、鉴定及其对磷脂膜和黑色素瘤细胞的影响 Yukuyama, M. N. PDF N/A Comparative study of Ergosterol and 7-dehydrocholesterol and their Endoperoxides: Generation, Identification and Impact in Phospholipid Membranes and Melanoma Cells
ConvNTC:用于预测疾病相关miRNA对和细胞相关药物对的卷积神经张量补全 Liu, P. PDF N/A ConvNTC: Convolutional neural tensor completion for predicting the disease-related miRNA pairs and cell-related drug pairs
揭示表位特异性TCR库的隐藏序列分布及其对机器学习模型性能的影响 Gielis, S. PDF N/A Revealing the hidden sequence distribution of epitope-specific TCR repertoires and its influence on machine learning model performance
ProteoSeeker:一款功能丰富的宏基因组分析工具,用于便捷且全面的宏基因组探索 Filis, G. PDF N/A ProteoSeeker: A Feature-Rich Metagenomic Analysis Tool for Accessible and Comprehensive Metagenomic Exploration
通过互补的综合结构生物学方法解析GPCR-G蛋白受体相互作用的分子决定因素 Castel, J. PDF N/A Deciphering molecular determinants of GPCR-G protein receptor interactions by complementary integrative structural biology methods
多聚磷酸盐比DNA更有效地区分蛋白质构象系综,促进多样化的组装和成熟行为。 Goyal, S. PDF N/A Polyphosphate Discriminates Protein Conformational Ensembles More Efficiently than DNA Promoting Diverse Assembly and Maturation Behaviors
时空谱系追踪揭示了肿瘤生长和转移的动态空间结构 Jones, M. G. PDF N/A Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis
周期素G相关激酶(GAK)是一种新型的有丝分裂激酶,也是弥漫性大B细胞淋巴瘤的治疗靶点。 Lightfuss, O. B. PDF N/A The cyclin-G associated kinase (GAK) is a novel mitotic kinase and therapeutic target in diffuse large B-cell lymphoma
NSD2通过整合素/FAK/AKT信号传导促进细胞硬度趋向性,并驱动从多囊肾病向囊性肾细胞癌的转变 Feng, W. PDF N/A NSD2 promotes cell durotaxis and drives the transition from PKD to tubulocystic renal cell carcinoma through integrin/FAK/AKT signaling
抑制肿瘤相关巨噬细胞中的PIM激酶可抑制炎症小体1的激活,并增强前列腺癌对免疫治疗的敏感性。 Clements, A. N. PDF N/A Inhibition of PIM kinase in tumor associated macrophages suppresses inflammasome 1 activation and sensitizes prostate cancer to immunotherapy
富集于突触信号传导的转录模式与高级别浆液性卵巢癌患者较短的生存期相关 Bhattacharya, A. PDF N/A Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
高级别浆液性卵巢癌中肿瘤-免疫动态的时间模型 Egan, D. PDF N/A A TEMPORAL MODEL OF TUMOR-IMMUNE DYNAMICS IN HIGH GRADE SEROUS OVARIAN CANCER
羟基聚乙二醇:一种有效规避人体预存抗PEG抗体的解决方案,以实现高效递送 Ding, T. PDF N/A Hydroxy polyethylene glycol: a solution to evade human pre-existing anti-PEG antibodies for efficient delivery
血压变异性损害中年小鼠的血管功能 Mendiola, P. J. PDF N/A Blood pressure variability compromises vascular function in middle-aged mice
有氧能力与运动通过增强胆汁酸代谢来介导对肝脏脂肪变性的保护作用。 Kugler, B. A. PDF N/A Aerobic capacity and exercise mediate protection against hepatic steatosis via enhanced bile acid metabolism.
从转录组数据驱动的布尔网络推断以预测细胞分化与重编程 Chevalier, S. PDF N/A Data-driven inference of Boolean networks from transcriptomes to predict cellular differentiation and reprogramming
通过单细胞RNA测序解析强直性脊柱炎中的代谢途径及蛋白质相互作用网络 Yarici, M. PDF N/A Deciphering Metabolic Pathways and Protein-Protein Interaction Networks in Ankylosing Spondylitis through Single-Cell RNA Sequencing
基于核滤波的自适应控制器在网络遗传学应用中的应用 Smart, B. C. PDF N/A Kernel Filter-Based Adaptive Controllers For Cybergenetics Applications
口服耐受的系统效应改善了身体不同部位多个和同时发生的伤口的愈合 Nobrega, I. B. C. PDF N/A Systemic effects of oral tolerance improve the healing of several and concomitant wounds in different body parts
维生素E补充剂可防止老年小鼠圆形精子细胞发生铁死亡 Germeraad, J. PDF N/A Vitamin E supplementation prevents ferroptosis in round spermatids of aged mice
RDAforest:识别多基因适应的环境驱动因素。 Matz, M. V. PDF N/A RDAforest: identifying environmental drivers of polygenic adaptation.
解析遗传性和可塑性对弗里蒙特杨树叶反射率在温度梯度上的影响 Seeley, M. M. PDF N/A Disentangling the effect of heritability and plasticity on Populus fremontii leaf reflectance across a temperature gradient
CADET:利用eQTL汇总数据在混合样本中增强转录组范围的关联分析 Head, S. T. PDF N/A CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data
GL15与FDL1之间的遗传相互作用调节了玉米幼苗角质层的沉积和叶片通透性 Castorina, G. PDF N/A Genetic interaction between GL15 and FDL1 modulates juvenile cuticle deposition and leaf permeability in maize
猕猴桃病原菌丁香假单胞菌猕猴桃致病变种3型的基因组生物监测揭示了其在新西兰果园中对选择压力的适应性 Hemara, L. M. PDF N/A Genomic biosurveillance of the kiwifruit pathogen Pseudomonas syringae pv. actinidiae biovar 3 reveals adaptation to selective pressures in New Zealand orchards
估计并纠正单细胞RNA测序数据中的索引跳跃误分配 Miao, L. PDF N/A Estimating and correcting index hopping misassignments in single-cell RNA-seq data
5-氟尿嘧啶处理下人细胞培养中RNA修饰的时间定位 Berg, M. PDF N/A Temporal placement of RNA modifications under 5-fluorouracil treatment in human cell culture
四个结构区域的流动性驱动植物LPOR的同工型特异性 Gabruk, M. PDF N/A Mobility of Four Structural Regions Drives Isoform-Specific Properties of Plant LPOR
发育中的哺乳动物视网膜中机械性能的尺度不变性 Shelton, E. R. PDF N/A Scale invariance of mechanical properties in the developing mammalian retina
通过信号分解和多尺度注意力克服分辨率增强Hi-C数据中的人工结构 Li, Q. PDF N/A Overcoming artificial structures in resolution-enhanced Hi-C data by signal decomposition and multi-scale attention
优化神经诱导中的信息传递限制了海鞘胚胎的细胞表面接触 Bettoni, R. PDF N/A Optimizing information transmission in neural induction constrains cell surface contacts of ascidian embryos
通过聚合物建模探索早衰症中的核纤层结构与解离 Hameed, H. A. PDF N/A Exploring Nuclear Lamina Structure and Lamin Dissociation in Progeria through Polymer Modeling
PolSpec:基于偏振的光谱分类检测方法 Liu, H. PDF N/A PolSpec: polarisation-based detection for spectral classification of optical signals
结构鉴定出RyR1的RY12域为ADP传感器,并作为恶性高热治疗药物丹曲林的目标 Kim, K. PDF N/A Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene
3D-UHU-TU:健康尿路上皮环境中的三维膀胱癌模型 Murray, B. O. PDF N/A 3D-UHU-TU: A Three-Dimensional Bladder Cancer Model in a Healthy Urothelial Environment
线粒体功能障碍与内质网应激在人神经母细胞瘤SH-SY5Y细胞中CB1受体拮抗剂诱导的细胞凋亡中的作用 Mori, K. PDF N/A Mitochondrial Dysfunction and ER Stress in CB1 Receptor Antagonist-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells
基于成像质谱流式技术引导的多模态质谱成像的超分辨率单细胞空间代谢组学 Ozturk, E. PDF N/A Super Resolved Single-Cell Spatial Metabolomics from Multimodal Mass Spectrometry Imaging guided by Imaging Mass Cytometry
首次记录入侵的黄蜂(Vespa velutina nigrithorax Buysson, 1905)和雕刻切叶蜂(Megachile sculpturalis Smith, 1853)在斯洛伐克的出现(膜翅目:胡蜂科和切叶蜂科) Purkart, A. PDF N/A First records of invasive Vespa velutina nigrithorax Buysson, 1905 (Hymenoptera: Vespidae) and Megachile sculpturalis Smith, 1853 (Hymenoptera: Megachilidae) in Slovakia
AEA对TAT处理的人星形胶质细胞的拮抗活性识别出炎症衰老通路 Duraikannu, D. PDF N/A Antagonistic activity of AEA on TAT treated Human Astrocytes identify Inflammaging pathways
RBP4作为孤儿DR6的拮抗配体发挥功能 Kim, T. PDF N/A RBP4 functions as an antagonistic ligand of orphan DR6
寄生虫物种多样性的维持:时空生态位分区和聚集促进物种共存 Ramesh, A. PDF N/A Maintenance of parasite species diversity: Spatiotemporal niche partitioning and aggregation facilitate species coexistence
真菌孢子季节在美国因气候变化而提前了二十年 Wu, R. PDF N/A Fungal spore seasons advanced across the US over two decades of climate change
全球范围内对敌害释放假说的检验揭示了本地植物和外来植物在食草行为上的相似模式 Galman, A. PDF N/A Global test of the enemy release hypothesis reveals similar patterns of herbivory across native and non-native plants
利用大规模层次聚类分析表观基因组间的统计关系 Kim, A. PDF N/A Statistical relationships across epigenomes using large-scale hierarchical clustering
单细胞分辨率DESI质谱成像通过10倍样品扩展 Xie, C. PDF N/A Single-Cell Resolution DESI Mass Spectrometry Imaging through 10-Fold Sample Expansion
T细胞受体多样性、癌症与性别:来自30,000个TCRβ库的洞察 Zahid, H. J. PDF N/A T Cell Receptor Diversity, Cancer and Sex: Insights from 30,000 TCRβ Repertoires
WRAD核心扰动损害了DNA复制的保真度,促进了胰腺癌中的免疫编辑 Citron, F. PDF N/A WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer
通过FBXW11和CTNNB1热点突变的互斥激活Wnt/β-catenin信号传导驱动唾液腺基底细胞腺瘤的发生 Wong, K. PDF N/A Activation of Wnt/β-catenin signalling by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary gland basal cell adenoma
建立和分子表征源自原发性中枢神经系统淋巴瘤患者的类器官 Li, S. PDF N/A Establishment and Molecular Characterization of Patient-Derived Organoids for Primary Central Nervous System Lymphoma
EFP分析器:一款快速、准确且易于教学的程序,用于分析由诱导多能干细胞衍生心肌细胞产生的外场电位 Patel, N. P. PDF N/A EFP Analyzer: A fast, accurate, and easy-to-teach program for analyzing Extracellular Field Potentials from iPSC-derived cardiomyocytes
hsa-miR-9-5p 在早发型子痫前期合体滋养层来源的细胞外囊泡中高表达,损害了脑微血管内皮细胞的促血管生成能力。 Logenthiran, P. V. PDF N/A hsa-miR-9-5p highly expressed in syncytiotrophoblast-derived extracellular vesicles from early-onset preeclampsia impairs cerebral microvascular endothelial cell pro-angiogenic capacity
T细胞表位图谱揭示了SARS-CoV-2蛋白质组中进化保守区域具有免疫优势。 Bozkus, C. C. PDF N/A T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.
DNA复制和修复机制之间的冲突会促进革兰氏阳性细菌的细胞死亡。 Gaimster, H. PDF N/A Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria
毒力调节并增强B群链球菌中的CRISPR-Cas9免疫 Pastuszka, A. PDF N/A Virulence regulates and boosts CRISPR-Cas9 immunity in Group B Streptococcus
FtsK 启动了在无 FtsZ 的沙眼衣原体中组装独特的分裂体复合物 Harpring, M. PDF N/A FtsK Initiates the Assembly of a Unique Divisome Complex in the FtsZ-less Chlamydia trachomatis
SARS-CoV-2在动物园老虎、狮子和鬣狗体内的种群扩张、多样化和适应 Bashor, L. PDF N/A SARS-CoV-2 within-host population expansion, diversification and adaptation in zoo tigers, lions and hyenas
通过完整组装揭示了不同小鼠亚种间端粒和着丝粒的结构多样性 Adams, D. PDF N/A The structural diversity of telomeres and centromeres across mouse subspecies revealed by complete assemblies
双工PCR检测法用于确定肩突硬蜱(蜱螨目:硬蜱科)的性别及交配状态,该蜱是莱姆病病原体的传播媒介。 Ronai, I. PDF N/A Duplex PCR assay to determine sex and mating status of Ixodes scapularis (Acari: Ixodidae), vector of the Lyme disease pathogen
去泛素化酶Rpn11作为一种变构泛素传感器,促进26S蛋白酶体与底物的结合。 Htet, Z. M. PDF N/A The deubiquitinase Rpn11 functions as an allosteric ubiquitin sensor to promote substrate engagement by the 26S proteasome
多花黄精根氟代聚磷酸-糖苷(NU2)通过靶向DNA拓扑异构酶I抑制多重耐药细菌和单细胞寄生虫 CHAKRABORTY, A. K. PDF N/A Suregada multiflora Root Fluro-PolyPhosphate-Glycoside (NU2) inhibits MDR Bacteria and Unicellular Parasites Targeting DNA Topoisomerase I
拓扑重排激活了HerA-DUF抗噬菌体防御系统 Rish, A. D. PDF N/A Topological rearrangements activate the HerA-DUF anti-phage defense system
利用光控开关鞘氨醇实现鞘脂生物合成的光学调控 Kol, M. PDF N/A Optical control of sphingolipid biosynthesis using photoswitchable sphingosines
从绿藻衣藻中高效分泌一种塑料降解酶 Molino, J. V. D. PDF N/A Efficient secretion of a plastic degrading enzyme from the green algae Chlamydomonas reinhardtii
利用纳米抗体与抗原相互作用调控铁氧还蛋白电子传递 Truong, A. PDF N/A Regulating ferredoxin electron transfer using nanobody and antigen interactions
基于CRISPRi的双功能逻辑门 Yao, Z. PDF N/A Dual-function logic gates based on CRISPRi
阐明异黄酮合酶介导的酵母蛋白质-蛋白质相互作用在代谢中的作用 Liu, C. PDF N/A Elucidating the metabolic roles of isoflavone synthase-mediated protein-protein interactions in yeast
用于单细胞分析的基因编码荧光条形码 Lu, X. PDF N/A Genetically-Encoded Fluorescence Barcodes for Single-Cell Analysis
将邻近标记酶展示于细胞外囊泡表面用于表面组及靶细胞的定位 ZHENG, W. PDF N/A Surface display of proximity labeling enzymes on extracellular vesicles for surfaceome and target cell mapping
I型干扰素诱导肝细胞中的GBPs和溶酶体防御,以控制疟疾 Marques-da-Silva, C. PDF N/A Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria
构建用于研究HIV-1复制及甲基苯丙胺影响的巨噬细胞嗜性亚型C HIV-1-mGreenLantern报告病毒 Mofed, D. PDF N/A Construction of a macrophage-tropic subtype C HIV-1-mGreenLantern reporter virus for studies on HIV-1 rep-lication and the impact of methamphetamine
脱氮微生物群落中协同作用的产生与破坏 Carr, A. V. PDF N/A Emergence and disruption of cooperativity in a denitrifying microbial community
非芳香化酶依赖的雌激素生成:Wood-Ljungdahl途径可能对生物圈中雌激素的出现有所贡献。 Wang, P.-H. PDF N/A Aromatase-independent estrogenesis: Wood-Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere
在土壤细菌向叶际过渡的早期阶段,确定性定殖现象便已出现,并受到植物与微生物相互作用的影响。 Mayer, T. PDF N/A Deterministic colonization arises early during the transition of soil bacteria to the phyllosphere and is shaped by plant-microbe interactions.
共生菌和致病菌附着于肠上皮细胞的肠道定殖动力学 Rivera, D. E. PDF N/A Dynamics of gut colonization by commensal and pathogenic bacteria that adhere to the intestinal epithelium
螺原体共生体减少宿主脂质合成及类Stomoxyn肽有助于舌蝇Glossina fuscipes抵抗锥虫 Awuoche, E. O. PDF N/A Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes
利用新型遗传方法进行端粒酶RNA的转运 Kirk, K. E. PDF N/A Trafficking of the Telomerase RNA using a Novel Genetic Approach
脑膜炎奈瑟菌B群荚膜多糖合成启动子的调控由HTH_XRE家族转录因子进行 Sofowora, I. PDF N/A Regulation of the Promoter for Capsular Polysaccharide Synthesis in Neisseria Meningitidis Serogroup B by HTH_XRE Family Transcription Factor
TFAM作为UVC诱导的线粒体DNA损伤的传感器 King, D. E. PDF N/A TFAM as a sensor of UVC-induced mitochondrial DNA damage
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针对与严重儿童癫痫和早逝相关的胎儿期富集钾通道的基因治疗 Golinski, S. PDF N/A Gene therapy for targeting a prenatally enriched potassium channel associated with severe childhood epilepsy and premature death
大规模突触成像揭示了视觉皮层神经元的突触输入结构,无需反向传播的动作电位 Kondo, S. PDF N/A Synaptic input architecture of visual cortical neurons revealed by large-scale synapse imaging without backpropagating action potentials
精神分裂症和健康个体在深部脑形态和不对称性方面存在性别差异:ENIGMA-精神分裂症工作组的元分析 Cimmino, D. PDF N/A Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group
树突图谱揭示纹状体D1/D2神经元形态的空间组织 Park, C. S. PDF N/A Dendritome Mapping Unveils Spatial Organization of Striatal D1/D2-Neuron Morphology
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