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BioRxiv 2024-10-30 Papers

标题 作者 PDF链接 代码仓库 Title
撤回:呼吸道合胞病毒感染细胞中形成的一种含有病毒RNA和G蛋白的膜性细胞器的超微结构特征 Vijayakrishnan, S. PDF N/A WITHDRAWN: Ultrastructural characterization of a viral RNA and G-protein containing, membranous organelle formed in respiratory syncytial virus infected cells
黏多糖贮积症III型A、B和C的小鼠模型显示出过度活跃以及少突胶质细胞状态的改变。 Gerken, E. PDF N/A Zebrafish models of Mucopolysaccharidosis types IIIA, B, & C show hyperactivity and changes in oligodendrocyte state
通过活细胞单分子成像揭示的核受体相互作用网络的惊人特征 Dahal, L. PDF N/A Surprising Features of Nuclear Receptor Interaction Networks Revealed by Live Cell Single Molecule Imaging
皮层-丘脑通信在熟练运动序列中的动作协调 Li, Y. PDF N/A Cortico-thalamic communication for action coordination in a skilled motor sequence
从大脑频谱特征预测主体特质:应用于大脑衰老的研究 Jarne, C. G. PDF N/A Predicting subject traits from brain spectral signatures: an application to brain ageing
从头注释小麦泛基因组揭示了六倍体小麦泛转录组的复杂性和多样性 White, B. PDF N/A De novo annotation of the wheat pangenome reveals complexity and diversity of the hexaploid wheat pan-transcriptome
数据驱动的AI系统,用于学习如何运行转录组装器 Shen, Y. PDF N/A Data-driven AI system for learning how to run transcript assemblers
一种通用且有效的去条纹变分方法:应用于光片显微镜、聚焦离子束扫描电镜和遥感图像 Rottmayer, N. PDF N/A A universal and effective variational method for destriping: application to light-sheet microscopy, FIB-SEM and remote sensing images
腹侧被盖区和黑质致密部神经递质定义的细胞类型的比例和分布 Conrad, W. S. PDF N/A Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta
基于精度的因果推断调节视听时间重校准 Li, L. PDF N/A Precision-based causal inference modulates audiovisual temporal recalibration
在9.4 T磁场下使用pCASL技术对啮齿动物进行高分辨率灌注成像 Pires Monteiro, S. PDF N/A High-resolution perfusion imaging in rodents using pCASL at 9.4 T
导航范围扩展促进迁徙性狩猎 Zhang, Y. PDF N/A Navigated range expansion promotes migratory culling
Foldclass 和 Merizo-search:基于嵌入的深度学习工具,用于蛋白质结构域分割、折叠识别和比较 Kandathil, S. M. PDF N/A Foldclass and Merizo-search: embedding-based deep learning tools for protein domain segmentation, fold recognition and comparison
自上而下起源的捕食者-猎物幂律的一般机制 Mazzarisi, O. PDF N/A General mechanisms for a top-down origin of the predator-prey power law
马尔可夫场网络整合多模态数据预测免疫系统扰动对猕猴静脉BCG疫苗接种的影响 Wang, S. PDF N/A Markov Field network integration of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques
疟原虫感染的红细胞的细胞粘附改变了脑内皮细胞中细胞因子、组蛋白和抗病毒蛋白编码基因的表达。 Allweier, J. PDF N/A Cytoadhesion of Plasmodium falciparum-infected red blood cells changes the expression of cytokine-, histone- and antiviral protein-encoding genes in brain endothelial cells
当常微分方程(ODEs)不可行时,信号传导途径的动态建模 Rachel, T. J. PDF N/A Dynamic modelling of signalling pathways when ODEsare not feasible
皮质对分层节奏的追踪协调了生物运动的多感官处理 Shen, L. PDF N/A Cortical tracking of hierarchical rhythms orchestrates the multisensory processing of biological motion
22q11.2缺失突变小鼠海马CA1区的抑制性动力学紊乱 Herrlinger, S. A. PDF N/A Disorganized Inhibitory Dynamics in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice
利用转录因子结合和启动子表观基因组模式的可解释模型揭示了在细胞类型背景下与疾病相关的基因及其调控因子。 Chandra, O. PDF N/A Explainable models using transcription factor binding and epigenome patterns at promoters reveal disease-associated genes and their regulators in the context of cell-types
使用Lamin B受体实现内质网膜接触位点的非破坏性可诱导标记 Downie, L. PDF N/A Non-disruptive inducible labeling of ER-membrane contact sites using the Lamin B Receptor
埃及伊蚊的VLG-1基因挑战了Vago基因被认为具有抗病毒特性的假设。 Couderc, E. PDF N/A Aedes aegypti VLG-1 challenges the assumed antiviral nature of Vago genes.
代谢驱动的氧化还原状态对线粒体网络形态的主动调控 Singh, G. PDF N/A Active control of mitochondrial network morphology by metabolism driven redox state
运输蛋白中最低能量路径的计算。 Yorke, B. A. PDF N/A Calculation of minimum energy pathways in transport proteins.
Cell Ranger版本对Chromium基因表达数据的影响 Abugessaisa, I. PDF N/A Impacts of Cell Ranger versions on Chromium gene expression data
chrna3 调节斑马鱼对酒精的反应 Raine, J. PDF N/A chrna3 modulates alcohol response in zebrafish
水体积、生物学重复和PCR重复影响深海浮游鱼类群落的特征化。 Peres, P. A. PDF N/A Water volume, biological and PCR replicates influence the characterization of deep-sea pelagic fish communities.
高分辨率活体内运动学追踪与可注射荧光纳米颗粒 Ulutas, E. Z. PDF N/A High-resolution in vivo kinematic tracking with injectable fluorescent nanoparticles
用泛扩展显微镜可视化核孔复合物的可塑性 Morgan, K. J. PDF N/A Visualizing nuclear pore complex plasticity with Pan-Expansion Microscopy
母体脂联素恢复了暴露于宫内母体肥胖的成年后代阻力血管中的胆碱能血管舒张 Murphy, M. PDF N/A Maternal adiponectin restores cholinergic vasodilation in resistance vessels from adult offspring exposed to maternal obesity in utero
凝聚素介导的染色质重塑调控传统树突状细胞的分化和功能 Adams, N. M. PDF N/A Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells
一种宿主导向的佐剂能够复苏并增强抗生素对胞内细菌持留菌的敏感性。 Lu, K.-Y. PDF N/A A host-directed adjuvant resuscitates and sensitizes intracellular bacterial persisters to antibiotics
鉴定单性异体和雌雄同体海洋鱼类物种中性二型循环微小RNA。 Geffroy, B. PDF N/A Identifying sexually dimorphic circulating microRNAs in gonochoristic and hermaphroditic marine fish species.
Prefoldin 5 是一种与微管相关的蛋白质,能够抑制Tau蛋白的聚集及其引发的神经毒性。 Bisht, A. PDF N/A Prefoldin 5 is a microtubule-associated protein that suppresses Tau-aggregation and neurotoxicity
在古菌中由机械压缩触发的类组织多细胞发育 Rados, T. PDF N/A Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea
在自然视觉过程中,人类视觉皮层早期的反应最好由扫视(saccade)的开始而不是注视(fixation)的开始来解释。 Amme, C. PDF N/A Saccade onset, not fixation onset, best explains early responses across the human visual cortex during naturalistic vision
热中性环境对小鼠MASLD严重程度、肝基因表达及β3-肾上腺素能刺激下BAT激活的影响 Martin, C. M. PDF N/A Effect of thermoneutral housing on MASLD severity, hepatic gene expression, and BAT activation during β3-adrenergic stimulation in mice
HP1/Swi6的磷酸化减轻了其与Suv39/Clr4在核小体上的竞争,并促进了H3K9三甲基化的扩展。 Kennedy, D. R. PDF N/A Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading.
在视觉引导的运动过程中,细胞类型特异性纹状体集合活动的动态失衡。 Fearey, B. PDF N/A Dynamic imbalances in cell-type specific striatal ensemble activity during visually guided locomotion.
利用表达引导性抗菌肽(gAMP)的生物工程益生菌对肿瘤相关微生物F. nucleatum进行靶向治疗 Choudhury, A. PDF N/A Targeted therapy of oncomicrobe F. nucleatum with bioengineered probiotic expressing guided antimicrobial peptide (gAMP)
针对肿瘤相关微生物具核梭杆菌(F. nucleatum)的靶向治疗:利用生物工程益生菌表达引导性抗菌肽(gAMP) Choudhury, A. PDF N/A Targeted therapy of oncomicrobe F. nucleatum with bioengineered probiotic expressing guided antimicrobial peptide (gAMP)
网格蛋白非依赖性内吞作用和癌细胞中的逆向运输促进了细胞毒性CD8 T细胞的激活。 Xu, S. PDF N/A Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation
对纯种赛马髁部应力骨折风险评估的虚拟力学测试流程进行调整与验证 Irandoust, S. PDF N/A Tuning and validation of a virtual mechanical testing pipeline for condylar stress fracture risk assessment in Thoroughbred racehorses
LIMPACAT:利用全切片成像的肝癌免疫预测多组学注意力变压器 Chiu, Y. J. PDF N/A LIMPACAT:Multi-Omics Attention Transformer for Immune Prediction in Liver Cancer Using Whole-Slide Imaging
渴望联系:探索印度家庭中孕期渴望、母亲健康与儿童偏好之间的关系 Kruthi, M. N. PDF N/A Craving Connections: Exploring the Relationship Between Pregnancy Cravings, Maternal Health, and Child Preferences in Indian Families
评估尼日利亚技术学院学生生物学能力与性别及生物学成绩的关系 Sowunmi, K. PDF N/A Assessing Technical College Students' Biology Proficiency as Related to Gender and Performance in Biology in Nigeria
肺腺癌患者肿瘤引流静脉中循环细胞外囊泡的新型蛋白质组学特征 Tricard, J. PDF N/A New proteomic signature in circulating extracellular vesicles from tumor-draining vein of lung adenocarcinomas patients
肝病变动态的个体患者数据分析:泛癌分析 Dickinson, J. PDF N/A Individual Patient Data Analysis of Liver Lesion Dynamics: A Pan Cancer Analysis
双侧初级运动皮层上的双站点经颅交流电刺激增加半球间抑制并改善双手灵巧性:一项三盲、随机、假刺激对照研究 Lebihan, B. PDF N/A Dual-site transcranial alternating current stimulation over the primary motor cortices increases interhemispheric inhibition and improves bimanual dexterity: A triple-blind, randomised, sham-controlled study
小脑性伸臂共济失调对运动学和动力学需求的敏感性 Oh, K. PDF N/A Sensitivity of Cerebellar Reaching Ataxia to Kinematic and Dynamic Demands
CYK-4 GAP结构域调节中心纺锤体向皮质区的定位,以促进收缩环的组装并促进环的溶解 Schlientz, A. J. PDF N/A The CYK-4 GAP domain regulates cortical targeting of centralspindlin to promote contractile ring assembly and facilitate ring dissolution
探索外泌体的粘附特性以用于功能性检测 Pachane, B. C. PDF N/A Exploring the adhesion properties of extracellular vesicles for functional assays
野生捕获的洞穴鱼睡眠损失的系统发育图谱 North, O. PDF N/A Phylogenetic mapping of sleep loss in wild-caught cavefish
双目竞争的意象启动并不是衡量个体在视觉化主观生动性方面差异的可靠指标。 Bouyer, L. PDF N/A Imagery priming of binocular rivalry is not a reliable metric of individual differences in the subjective vividness of visualisations.
利用运动学时间序列数据的神经网络分析识别中风后和神经正常步态行为的独特亚型 Kuch, A. PDF N/A Identification of distinct subtypes of post-stroke and neurotypical gait behaviors using neural network analysis of kinematic time series data
军事野外训练前后手部和前臂皮肤细菌群落动态变化 Glenna, S. PDF N/A Skin bacterial community dynamics of hands and forearms before and after military field exercise
白细胞通过内皮膜隧道渗出血管 van der Meer, W. PDF N/A Leukocytes use endothelial membrane tunnels to extravasate the vasculature
N-Myc下游调控基因-1调控整合素表达以抑制胃癌转移的机制 Wang, T. PDF N/A Mechanism of N-Myc Downstream Regulated Gene-1 regulating Integrin expression to inhibit gastric cancer metastasis
PET微塑料增加了胰岛素抵抗和胰腺炎的风险 Mierzejewski, K. PDF N/A PET microplastics increase the risk of insulin resistance and pancreatitis
苯并噁嗪途径与玉米硼稳态的关联 Chu, L. PDF N/A Association of the benzoxazinoid pathway with boron homeostasis in maize
向日葵HaHB4基因在现代小麦中的渐渗:应对气候变化抗逆性提升的一项进展 Ayala, F. PDF N/A Introgression of the sunflower HaHB4 gene in modern wheat: An advancement in resilience to deal with climate change
双侧颅内电磁刺激顶下小叶-海马网络增强人类长期记忆 Borghi, I. PDF N/A Dual transcranial electromagnetic stimulation of the precuneus-hippocampus network boosts human long-term memory
一种新型早发性脊髓小脑共济失调13号BAC小鼠模型,具有小脑发育不全、震颤和共济失调步态 Yin, J. PDF N/A A Novel Early Onset Spinocerebellar Ataxia 13 BAC Mouse Model with Cerebellar Hypoplasia, Tremor, and Ataxic Gait
系统性炎症和淋巴细胞活化先于类风湿性关节炎 He, Z. PDF N/A Systemic inflammation and lymphocyte activation precede rheumatoid arthritis
灭绝涡旋的驱动更多地源于有益突变的匮乏,而非有害突变的积累。 Mawass, W. PDF N/A Extinction vortices are driven more by a shortage of beneficial mutations than by deleterious mutation accumulation
病毒感染中祖细胞的基因组分析表明,糖皮质激素抑制了浆细胞样树突状细胞的生成 Jo, Y. PDF N/A Genomic Analysis of Progenitors in Viral Infection Implicates Glucocorticoids as Suppressors of Plasmacytoid Dendritic Cell Generation
中等剂量辐射会损害长期造血干细胞功能,并影响对细胞毒性应激的造血恢复。 Zhang, Q. PDF N/A Medium-dose irradiation impairs long-term hematopoietic stem cell functionality and hematopoietic recovery to cytotoxic stress
Ta3N5诱导U2OS人类癌细胞凋亡 Nozaki, T. PDF N/A Induction of cell death in U2OS human cancer cells by Ta3N5
硅胶表面上的免疫细胞死亡会驱动生物膜的形成。 Jagirdar, S. K. PDF N/A Immune cell death on silicone surfaces drives biofilm formation
探索胶质瘤细胞和细胞外囊泡中的N6-甲基腺苷及长链转录本。 Batool, S. M. PDF N/A Exploring N6-Methyladenosine and long transcripts in glioma cells and extracellular vesicles.
比较时空单细胞转录组揭示了C4禾本科植物中克朗兹解剖结构出现期间现有调控的重塑 Zhao, C. PDF N/A Comparative spatiotemporal single cell transcriptomes reveal rewiring of pre-existing regulations during emergence of Kranz anatomy in C4 grasses
受影响力数据驱动的科学推理:重振dfstat! Spiess, A. N. PDF N/A Scientific reasoning driven by influential data: resuscitate dfstat!
早期职业研究(ECR)中导师-学员关系的调查:对STEMM学科发表和职业发展的启示 Lordan, R. PDF N/A A survey of the mentor-mentee relationship in early career research (ECR): Implications for publishing and career advancement in the STEMM disciplines
将产前和围产期风险因素与儿童皮质结构的多变量融合联系起来 Lindseth, L. R. PDF N/A Linking Pre- and Perinatal Risk Factors to a Multivariate Fusion of Child Cortical Structure
Salinispora中酮霉素类似物的结构解析、生物合成基因簇分布及生物活性 Castro-Falcon, G. PDF N/A Structure elucidation, biosynthetic gene cluster distribution, and biological activities of ketomemicin analogs in Salinispora
生物衰老的标志、机制和指标:范围综述 Ziesel, A. PDF N/A Markers, Mechanisms and Metrics of Biological Aging: A Scoping Review
分层分析将HIF-2α确定为高度免疫浸润性黑色素瘤的治疗靶点。 Huang, A. Y. PDF N/A Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas
针对SARS-CoV-2变种的中和纳米抗体的深度生成设计 Huo, L. PDF N/A Deep generative design of neutralizing nanobodies againstSARS-CoV-2 variants
从菠萝(Ananas comosus)中分离出的果胶酶细菌,命名为Dickeya ananae sp. nov. Dobhal, S. PDF N/A Dickeya ananae sp. nov., pectinolytic bacterium isolated from pineapple (Ananas comosus)
奈妥匹坦对结核分枝杆菌持留菌表现出强效活性 Eldesouky, H. E. PDF N/A Netupitant Exhibits Potent Activity on Mycobacterium tuberculosis Persisters
一种垂直和水平传播的RNA病毒促进寄生蜂卵的孵化 Izraeli, Y. PDF N/A A Vertically and Horizontally Transmitted RNA Virus Facilitates Egg Hatching of a Parasitoid Wasp
在深海中,SAR11谱系的序列离散物种的形成基础是随机且无偏好的重组。 Zhao, J. PDF N/A Promiscuous and unbiased recombination underlies the sequence-discrete species of the SAR11 lineage in the deep ocean
鉴定JC多瘤病毒中的新型环状转录本 Iida, S. PDF N/A Identification of novel wraparound transcripts in JC polyomavirus
微管蛋白样蛋白CetZ1和CetZ2在古菌Haloferax volcanii的细胞形态发生中起协调作用 Brown, H. J. PDF N/A Tubulin-like proteins CetZ1 and CetZ2 coordinate cellular morphogenesis in the archaeon Haloferax volcanii
由以厌氧甲烷氧化古菌(ANME archaea)为主导的共生体从烃类物质中产生甲烷 Sarno, N. PDF N/A Methane production from hydrocarbons by consortia dominated by ANME archaea
RNA外切体通过调控大脑中转录本的丰度来维持细胞RNA稳态。 Higginson, L. A. PDF N/A The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain
蜻蜓分子系统发育研究的新标记,包括保守组蛋白H3和H4基因的部分及它们之间的间隔区 Mglinets, A. V. PDF N/A A new marker for molecular phylogenetic studies in Odonata including parts of conservative histone H3 and H4 genes and spacer between them
组蛋白乙酰转移酶p300对RORβ的乙酰化以及SIRT1的去乙酰化作用,调节了受体的稳定性、更新速率及转录活性。 O'Leary, T. R. PDF N/A Acetylation of RORβ by lysine acetyltransferase p300 and deacetylation by SIRT1 modulates receptor stability, turnover and transcriptional activity.
RNA聚合酶I转录起始效率及起始位点选择的决定因素 Parilova, O. PDF N/A Determinants of transcription initiation efficiency and start site selection by RNA polymerase I
静电相互作用决定了纳库巴坦对OXA-48样β-内酰胺酶的效能 Hoff, J. F. PDF N/A Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases
体内特定部位的UFMylome定量分析揭示了肌球蛋白在ALS中的修饰 Blazev, R. PDF N/A Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS
自文档化质粒 Peccoud, S. J. PDF N/A Self-Documenting Plasmids
长上下文蛋白质语言模型 Wang, Y. PDF N/A Long-context Protein Language Model
一种基于大肠杆菌染色体的动态三维聚合物模型,由光学组合筛选的数据驱动。 Schirman, D. PDF N/A A dynamic 3D polymer model of the Escherichia coli chromosome driven by data from optical pooled screening
噬菌体CRISPR样调控RNA抑制细菌的适应性和先天免疫 Liu, C. PDF N/A Phage CRISPR-like regulatory RNAs silence bacterial adaptive and innate immunity
全基因组抗生素-CRISPRi分析揭示了将LiaR激活作为恢复氟喹诺酮耐药性肺炎链球菌敏感性策略的发现 Sewgoolam, B. PDF N/A Genome-wide antibiotic-CRISPRi profiling identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant Streptococcus pneumoniae
可咀嚼的鼠李糖乳杆菌GG在鼻腔内定植,并促进过敏性鼻结膜炎患者的局部免疫益处 De Boeck, I. PDF N/A Lacticaseibacillus rhamnosus GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients
磷酸盐改良剂在土壤湿润后促使RNA病毒大量繁殖 Sieradzki, E. T. PDF N/A Phosphate amendment drives bloom of RNA viruses after soil wet-up
温和链球菌糖脂的生物合成及其在生理和抗生素敏感性中的作用 Wei, Y. PDF N/A Biosynthesis of mitis group streptococcal glycolipids and their roles in physiology and antibiotic susceptibility
外源性脂肪酸通过在磷脂合成中与内源性和外源性生成的底物之间的竞争,抑制了大肠杆菌中的脂肪酸合成。 van den Berg, S. P. H. PDF N/A Exogenous fatty acids inhibit fatty acid synthesis through competition between endogenously- and exogenously-generated substrates for phospholipid synthesis in Escherichia coli
增强型Nme2Cas9和Nme2SmuCas9核酸酶及碱基编辑器的合理设计 Bamidele, N. PDF N/A Rational Design of Enhanced Nme2Cas9 and Nme2SmuCas9 Nucleases and Base Editors
SeqTagger,一个快速且精准的工具,用于解复用直接RNA纳米孔测序数据集 Pryszcz, L. P. PDF N/A SeqTagger, a rapid and accurate tool to demultiplex direct RNA nanopore sequencing datasets
一种组合域筛选平台揭示了转录扰动中的表观遗传效应物相互作用 Moon, H. C. PDF N/A A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation
单纯疱疹病毒1型起源结合蛋白UL9通过分子内和分子间的方式将起源DNA和非起源DNA连接和环化。 Meier, A. F. PDF N/A Herpes simplex virus type 1 origin binding protein UL9 tethers and loops origin- and non-origin-DNA intra- and intermolecularly
在ORC缺陷细胞中选择性起源和MCM2-7功能的过度加载。 Shibata, Y. PDF N/A Specific origin selection and excess functional MCM2-7 loading in ORC-deficient cells.
滑膜成纤维细胞中的O-糖基化驱动软骨降解 Tran, L. S. PDF N/A ER O-glycosylation in synovial fibroblasts drives cartilage degradation
人类精子发生导致核孔结构和功能的减少 dos Santos, A. PDF N/A Human spermatogenesis leads to a reduced nuclear pore structure and function
复合素2在调节胰岛郎格汉斯细胞激素分泌中的作用 Ng, X. W. PDF N/A Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans
神经元和星形胶质细胞具有不同的细胞器特征和应激反应。 Rhoads, S. N. PDF N/A Neurons and astrocytes have distinct organelle signatures and responses to stress
AlphaFold 2,而非AlphaFold 3,能够预测出对重复蛋白质具有高度信心但不切实际的beta-螺旋结构。 Pratt, O. S. PDF N/A AlphaFold 2, but not AlphaFold 3, predicts confident but unrealistic beta-solenoid structures for repeat proteins
用于土壤真菌间细胞通讯多重筛选的综合平台 Schiesaro, G. PDF N/A A synthetic platform for multiplex screening of cell-cell communication between soil fungi
TXNIP通过介导LAT1/SLC7A5的内吞作用,减少进入静止状态的细胞对氨基酸的摄取。 Kahlhofer, J. PDF N/A TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence