| 在没有内侧前额叶皮层的情况下，行为的认知控制和海马信息处理 |
Park, E. |
PDF |
N/A |
Cognitive control of behavior and hippocampal information processing without medial prefrontal cortex |
| 硬皮病亚型中独特的T细胞染色质景观 |
Dou, D. R. |
PDF |
N/A |
Distinct T cell chromatin landscapes in scleroderma subtypes |
| 利用全基因组谱系估计扩散速率并定位遗传祖先 |
Osmond, M. |
PDF |
N/A |
Estimating dispersal rates and locating genetic ancestors with genome-wide genealogies |
| 个体在体验多样性方面的差异塑造了事件分割的粒度。 |
Hodgetts, C. J. |
PDF |
N/A |
Individual differences in experiential diversity shape event segmentation granularity |
| 光环：单细胞多组学数据的层次因果建模 |
Mao, H. |
PDF |
N/A |
HALO: Hierarchical Causal Modeling for Single Cell Multi-Omics Data |
| 人类线粒体基因组编码一种干扰素应答的宿主防御肽 |
Rice, M. C. |
PDF |
N/A |
The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide |
| 利用Renoir绘制空间配体-靶标活性图 |
Rao, N. |
PDF |
N/A |
Charting spatial ligand-target activity using Renoir |
| 柳雷鸟种群的长期趋势与短期动态 |
Willebrand, T. |
PDF |
N/A |
Long term trend and short-term dynamics of a willow grouse population |
| 磷脂酰肌醇和小热休克蛋白对NRF2的调控 |
Chen, C. |
PDF |
N/A |
Regulation of NRF2 by Phosphoinositides and Small Heat Shock Proteins |
| 罕见的neurexin-1杂合缺失的表型复杂性 |
Fernando, M. B. |
PDF |
N/A |
Phenotypic complexities of rare heterozygous neurexin-1 deletions |
| 中介亚基Med4在乳腺癌中强制执行转移性休眠 |
Bae, S.-Y. |
PDF |
N/A |
Mediator Subunit Med4 Enforces Metastatic Dormancy in Breast Cancer |
| 单细胞转录组图谱揭示了急性髓系白血病中异常分化的遗传和非遗传决定因素 |
Zeng, A. G. X. |
PDF |
N/A |
Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML |
| 高分辨率分子动力学模拟：丙酮酸激酶肌肉同工酶1和2（PKM1/2） |
Delobelle, Q. |
PDF |
N/A |
High-resolution Molecular Dynamics Simulations of the Pyruvate Kinase Muscle Isoform 1 and 2 (PKM1/2) |
| 一种用于建模蛋白质液-液相分离的变分图划分方法 |
Wang, G. |
PDF |
N/A |
A Variational Graph Partitioning Approach to Modeling Protein Liquid-liquid Phase Separation |
| 事件分割的神经基础：环境中的稳定特征通过神经状态得以反映 |
Oetringer, D. |
PDF |
N/A |
The Neural Basis of Event Segmentation:Stable Features in the Environment areReflected by Neural States |
| 通过双功能HSV载体治疗性疫苗清除慢性SIV感染猕猴中的病毒潜伏期 |
Wen, Z. |
PDF |
N/A |
Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques |
| 抑制间接通路活性导致在帕金森病冲动控制障碍小鼠模型中出现异常决策行为 |
Zhuang, X. |
PDF |
N/A |
Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson's Disease |
| 自动浮游生物监测表明，微型浮游动物和温度在预测浮游植物大小类群的动态变化中起着关键作用。 |
Merkli, S. |
PDF |
N/A |
Automated plankton monitoring suggests a key role of microzooplankton and temperature for predicting dynamics of phytoplankton size classes |
| 分子洞察：hERG激活剂对严重LQT2突变体的救援机制研究。 |
Kumawat, A. |
PDF |
N/A |
Molecular Insights into the Rescue Mechanism of an hERG Activator Against Severe LQT2 Mutations. |
| 药物基因组学合成致死筛选揭示了NF1相关肿瘤的潜在脆弱性和新的治疗策略 |
Williams, K. B. |
PDF |
N/A |
Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors |
| 微切割肿瘤立方体：一种保留复杂肿瘤微环境的微尺度癌症模型，适用于大规模测试 |
Horowitz, L. F. |
PDF |
N/A |
Microdissected tumor cuboids: a microscale cancer model for large-scale testing that retains a complex tumor microenvironment |
| 在发病率高的地区，持续的跨物种传播系统主导了产志贺毒素大肠杆菌O157:H7的流行病学：一项基因组流行病学研究 |
Tarr, G. A. M. |
PDF |
N/A |
Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study |
| 串联重复蛋白为工程生物分子凝聚体引入了可调的特性。 |
Ng, T. L. C. |
PDF |
N/A |
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates |
| 人类在短暂先天视觉剥夺后视觉皮层兴奋/抑制比率的改变 |
Pant, R. |
PDF |
N/A |
Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans |
| 筛选大猩猩博物馆标本中的DNA病毒 |
Haemmerle, M. |
PDF |
N/A |
Screening great ape museum specimens for DNA viruses |
| 使用基于Shapley值的特征子集选择方法识别区分旁系同源蛋白的关键氨基酸类型 |
Machingal, P. |
PDF |
N/A |
Identifying key amino acid types that distinguish paralogous proteins using Shapley value based feature subset selection |
| LETSmix：一种空间感知且基于学习的领域自适应方法，用于空间转录组学中的细胞类型反卷积 |
Zhan, Y. |
PDF |
N/A |
LETSmix: a spatially informed and learning-based domain adaptation method for cell-type deconvolution in spatial transcriptomics |
| 前额叶5α-还原酶2介导雄性特异的急性应激反应 |
Cadeddu, R. |
PDF |
N/A |
Prefrontal 5α-reductase 2 mediates male-specific acute stress response |
| 一种新型进食机制：太阳鸟通过舌内吸吮的方式饮用花蜜 |
Cuban, D. |
PDF |
N/A |
A novel feeding mechanism: Sunbirds drink nectar via intralingual suction |
| 使用可穿戴、免手持系统对体外病原菌中卟啉特异性荧光进行成像 |
Sun, J. |
PDF |
N/A |
Imaging of porphyrin-specific fluorescence in pathogenic bacteria in vitro using a wearable, hands-free system |
| 使用可解释的非结构化元数据建模对公开可用的样本和研究进行标注 |
Yuan, H. |
PDF |
N/A |
Annotating publicly-available samples and studies using interpretable modeling of unstructured metadata |
| 水网络中的熵变促进蛋白质变性 |
Wang, Y. |
PDF |
N/A |
Entropy Changes in Water Networks Promote Protein Denaturation |
| 功能性适应的大脑结构基集：一种动态融合方法 |
Duda, M. |
PDF |
N/A |
Functionally Adaptive Structural Basis Sets of the Brain: A Dynamic Fusion Approach |
| 前额叶皮层和腹侧海马核伏隔核输入的奖励整合协同调节参与度 |
Iyer, E. S. |
PDF |
N/A |
Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement |
| 哈茨木霉T22诱导根瘤菌和类黄酮驱动的共生关系，促进豌豆对缺铁的耐受性。 |
Thapa, A. |
PDF |
N/A |
Trichoderma afroharzianum T22 induces rhizobia and flavonoid-driven symbiosis to promote iron deficiency tolerance in garden pea |
| 在成年功能连接网络中，大脑区域的一个子集在早期发育过程中表现出高度的可靠性。 |
Tu, J. C. |
PDF |
N/A |
A subset of brain regions within adult functional connectivity networks demonstrate high reliability across early development |
| plectin介导的细胞骨架串扰作为抑制肝细胞癌生长和转移的靶点。 |
Outla, Z. |
PDF |
N/A |
Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis. |
| 开发一种免疫分析方法用于检测和诊断由产甲烷古菌引起的微生物诱导腐蚀 |
Lahme, S. |
PDF |
N/A |
Development of an immunoassay for the detection and diagnosis of microbially-influenced corrosion caused by methanogenic Archaea |
| 使用深度学习在冷冻电镜和X射线图中识别配体 |
Karolczak, J. |
PDF |
N/A |
Ligand Identification in CryoEM and X-ray Maps Using Deep Learning |
| 生物学约束的脉冲神经网络用于脊髓损伤后运动功能恢复的神经调节 |
Chia, R. |
PDF |
N/A |
Biologically-Constrained Spiking Neural Network for Neuromodulation in Locomotor Recovery after Spinal Cord Injury |
| 结合骑行性高温与紫锥菊苷对胰腺癌细胞PANC-1产生协同治疗效果 |
Chen, W.-T. |
PDF |
N/A |
Combination of cycling hyperthermia and Echinacoside creates synergistic curing effect on pancreatic cancer PANC-1 cells |
| 针对牛繁殖失败相关病原体的靶向综合下一代测序面板，用于同时检测病原体。 |
Periyasamy, D. |
PDF |
N/A |
Targeted syndromic next-generation sequencing panel for simultaneous detection of pathogens associated with bovine reproductive failure |
| 不仅仅是果香：番荔枝科植物的花部生物学、香气和光谱反射率 |
Liu, M.-F. |
PDF |
N/A |
More than fruity scents: floral biology, scent and spectral reflectance of Annonaceae species |
| 使用HarmoDecon缓解空间分辨转录组学中细胞类型反卷积的多尺度偏差 |
Wang, Z. |
PDF |
N/A |
Mitigation of multi-scale biases in cell-type deconvolution for spatially resolved transcriptomics using HarmoDecon |
| 纹状体侧向抑制调节左旋多巴诱发运动障碍小鼠模型中的动作选择 |
Twedell, E. L. |
PDF |
N/A |
Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia |
| NAD的二核苷酸结构使其能够在矿物表面上进行特定的还原作用。 |
Pereira, D. P. H. |
PDF |
N/A |
The dinucleotide structure of NAD enables specific reduction on mineral surfaces |
| 阴离子脂质对阴离子交换蛋白1（AE1）构象转变能量景观的影响 |
Chen, T. |
PDF |
N/A |
Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1) |
| 鉴定和表征从淡水斑马贻贝（Dreissena bugensis）中提取的一种湿粘蛋白 |
Obille, A. R. |
PDF |
N/A |
Identification and characterization of a wet adhesive protein extracted from Dreissena bugensis, the freshwater quagga mussel |
| 丝裂霉素C与低剂量甲硝唑联合使用对艰难梭菌感染及其复发具有协同预防作用 |
Gong, J.-J. |
PDF |
N/A |
Combination of mitomycin C and low-dose metronidazole synergistically against Clostridioides difficile infection and recurrence prevention |
| 研究Huntingtin蛋白的Nt17结构域的曲率感应 |
Nanajkar, N. |
PDF |
N/A |
Investigating curvature sensing by the Nt17 domain of Huntingtin protein |
| TFAM作为UVC诱导的线粒体DNA损伤的传感器 |
King, D. E. |
PDF |
N/A |
TFAM as a sensor of UVC-induced mitochondrial DNA damage |
| 生长素-水杨酸跷跷板调控植物生长与食草动物防御之间的年龄依赖性平衡 |
Han, W.-H. |
PDF |
N/A |
Auxin-salicylic acid seesaw regulates the age-dependent balance between plant growth and herbivore defense |
| ProteinWeaver：一个用于可视化本体注释蛋白质网络的网络工具 |
Anderson, O. F. |
PDF |
N/A |
ProteinWeaver: A Webtool to Visualize Ontology-Annotated Protein Networks |
| Neuroligin 3 突显了果蝇社交距离中的性别二态性电路 |
Robinson, J. W. |
PDF |
N/A |
Neuroligin 3 highlights sexually dimorphic circuitry in Drosophila social spacing |
| CFC-seq：全长加帽RNA的鉴定揭示增强子来源的转录 |
Yip, C. W. |
PDF |
N/A |
CFC-seq: identification of full-length capped RNAs unveil enhancer-derived transcription |
| TIPP3 和 TIPP3-fast：改进的宏基因组丰度分析 |
Shen, C. |
PDF |
N/A |
TIPP3 and TIPP3-fast: Improved Abundance Profiling in Metagenomics |
| 小鼠、猕猴和人类中一致的单神经元时间尺度层次结构 |
Zeisler, Z. R. |
PDF |
N/A |
Consistent hierarchies of single-neuron timescales in mice, macaques and humans |
| 基底神经节和小脑回路在运动学习期间丘脑的整合作用 |
Roth, R. H. |
PDF |
N/A |
Thalamic integration of basal ganglia and cerebellar circuits during motor learning |
| 在假定的敏感期，青少年的前额叶皮层比成年人表现出更强的群体水平信息编码能力。 |
Klinger, M. |
PDF |
N/A |
The adolescent frontal cortex shows stronger population-level encoding of information than the adult during a putative sensitive period |
| 产前应激通过损害胎盘的糖皮质激素屏障功能，增加了后代皮质酮的水平。 |
Liu, C. |
PDF |
N/A |
Prenatal stress increases corticosterone levels in offspring by impairing placental glucocorticoid barrier function |
| 预测的受限可及区域标记调控元件和因果变异 |
Tomizuka, K. |
PDF |
N/A |
Predicted constrained accessible regions mark regulatory elements and causal variants |
| 齿状回去甲肾上腺素渐增促进厌恶情境加工 |
Zhang, E. T. |
PDF |
N/A |
Dentate Gyrus Norepinephrine Ramping Facilitates Aversive Contextual Processing |
| 新环境暴露驱动了海马体中时间定义和区域特异性的染色质可及性和基因表达变化 |
Duffy, E. E. |
PDF |
N/A |
Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus |
| 三重标记通过三色单分子FRET解析GPCR的中间状态 |
Bonhomme, L. |
PDF |
N/A |
Triple labeling resolves a GPCR intermediate state by 3-color single molecule FRET |
| 内在无序蛋白质内部基于电荷的瞬时相互作用的结构和功能相关性 |
Wohl, S. |
PDF |
N/A |
Structural and Functional Relevance of Charge Based Transient Interactions inside Intrinsically Disordered Proteins |
| H1和H3血凝素跨膜结构域以不同方式参与膜融合 |
Borkowska, P. |
PDF |
N/A |
Transmembrane domains of H1 and H3 hemagglutinin contribute to membrane fusion in a different manner |
| 从分子动力学模拟中学习Gα蛋白的变构相互作用 |
Yu, Y. |
PDF |
N/A |
Learning allosteric interactions in Gα proteins from molecular dynamics simulations |
| COCOMO2：一种用于相互作用的折叠和无序蛋白质的粗粒度模型 |
Jussupow, A. |
PDF |
N/A |
COCOMO2: A coarse-grained model for interacting folded and disordered proteins |
| 通过质谱和反相蛋白阵列分析的全蛋白质组、磷酸蛋白质组和糖蛋白质组的泛癌细胞系全景图 |
Shi, W. |
PDF |
N/A |
The Whole Proteome, Phosphoproteome, and Glycoproteome Landscape of Pan-Cancer Cell Lines Profiled by Mass Spectrometry and Reverse Phase Protein Array |
| 一种针对RSV和hMPV融合糖蛋白抗原位点V的中和性和保护性人类抗体 |
Abu-Shmais, A. A. |
PDF |
N/A |
A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein |
| mGluR6先天性静止性夜盲突变体的糖基化缺陷及与ELFN1的结合异常 |
Pindwarawala, M. |
PDF |
N/A |
Defective glycosylation and ELFN1 binding of mGluR6 congenital stationary night blindness mutants |
| 代谢调控糖基化形式以建立糖基依赖的蛋白质相互作用网络 |
Liu, X. |
PDF |
N/A |
Metabolic Control of Glycosylation Forms for Establishing Glycan-Dependent Protein Interaction Networks |
| 通过引导AlphaFold2利用距离分布建模蛋白质构象。应用于双电子电子共振（DEER）光谱学。 |
Wu, T. |
PDF |
N/A |
Modeling Protein Conformations by Guiding AlphaFold2 with Distance Distributions. Application to Double Electron Electron Resonance (DEER) Spectroscopy. |
| 结构环境调节α-突触核蛋白内在无序氨基末端的构象集合 |
Dumarieh, R. |
PDF |
N/A |
Structural context modulates the conformational ensemble of the intrinsically disordered amino terminus of α-synuclein |
| 在认知需求增加时，齿状回的局部活动会增强。 |
Castillon, C. |
PDF |
N/A |
Subregional activity in the dentate gyrus is amplified during elevated cognitive demands |
| 细菌中一种非常规G蛋白复合物对细胞极性的调控 |
Mignot, T. |
PDF |
N/A |
Cell polarity control by an unconventional G-protein complex in bacteria |
| 巴基斯坦旁遮普省生产的面包废料对罗非鱼幼鱼的表观消化率和营养表现 |
Hussain, S. S. |
PDF |
N/A |
Apparent digestibility and nutritional performance of bakery waste produced in Punjab Pakistan for Labeo rohita fingerlings |
| 脂质运输Mla Pqi嵌合系统对布鲁氏菌在巨噬细胞中的生存至关重要 |
Lannoy, A. |
PDF |
N/A |
A lipid transport Mla Pqi Chimeric system is essential for Brucella abortus survival in macrophages |
| 全基因组研究大肠杆菌外膜蛋白家族在马赛克进化中的情况 |
Cao, X. |
PDF |
N/A |
Genome-wide investigation of outer membrane protein families under mosaic evolution in Escherichia coli |
| 合成磁性纳米颗粒的生物功能化涂层能够实现对细胞内蛋白质功能的磁遗传控制。 |
Kappen, M. |
PDF |
N/A |
Biofunctional coating of synthetic magnetic nanoparticles enables magnetogenetic control of protein functions inside cells |
| cryoMDM：基于噪声冷冻电镜单颗粒图像的分子模拟驱动结构匹配方法，用于估计多种原子三维模型。 |
Tokuhisa, A. |
PDF |
N/A |
cryoMDM; Molecular simulation Driven structural Matching Approach to Estimate Variety of Atomic Three-dimensional Model Based on Noisy cryoEM Single Particle Images. |
| 全原子模拟阐明了RNA与膜相互作用的分子机制 |
Di Marco, S. |
PDF |
N/A |
All-atom simulations elucidate the molecular mechanismunderlying RNA-membrane interactions |
| 系统性抑制从头嘌呤生物合成通过增加产热和减少食物摄入，防止体重增加并改善代谢健康。 |
Myers, J. W. |
PDF |
N/A |
Systemic inhibition of de novo purine biosynthesis prevents weight gain and improves metabolic health by increasing thermogenesis and decreasing food intake |
| 软X射线断层扫描的自动分割：在酵母全细胞定量成像中实现高通量下亚微米分辨率的天然细胞结构 |
Chen, J.-H. F. |
PDF |
N/A |
Automated segmentation of soft X-ray tomography: native cellular structure with sub-micron resolution at high throughput for whole-cell quantitative imaging in yeast |
| 直接胰岛素分泌发生在具有最佳ELKS含量的精确皮层区域，这些区域缺乏微管结构。 |
Fye, M. A. |
PDF |
N/A |
Directed insulin secretion occurs at precise cortical regions with optimal ELKS content that are devoid of microtubules |
| 有机组织结构是预测气道模型中全氟碳化合物暴露结果的必要条件。 |
Liu, S. W. |
PDF |
N/A |
Organotypic tissue architecture is a requisite for predictive outcomes of perfluorocarbon exposure in airway models |
| 来自组织微环境的Tenascin-C通过Annexin A2促进肌肉干细胞自我更新。 |
Loreti, M. |
PDF |
N/A |
Tenascin-C from the tissue microenvironment promotes muscle stem cell self-renewal through Annexin A2 |
| 改变肾脏血管模式可减轻缺血性肾损伤，并限制与衰老相关的血管损失 |
McLarnon, S. R. |
PDF |
N/A |
Altered renal vascular patterning reduces ischemic kidney injury and limits vascular loss associated with aging |
| 最佳竞争者：互利共生者（如传粉者）的吸引力与选择之间的平衡推动了促进作用，并可能促进作物传粉。 |
Dornhaus, A. |
PDF |
N/A |
Optimal competitors: the balance of attraction and choices of mutualists, like pollinators, drives facilitation and may promote crop pollination |
| 通过微调蛋白质和小分子语言模型学习结合亲和力 |
Gorantla, R. |
PDF |
N/A |
Learning Binding Affinities via Fine-tuning of Protein and Ligand Language Models |
| 波形蛋白与nesprin-3的分子连接通过细胞几何约束增强了细胞核的变形 |
Swoger, M. |
PDF |
N/A |
Vimentin molecular linkages with nesprin-3 enhance nuclear deformation by cell geometric constraints |
| 单个细胞能够感知分等级的刺激 |
Kramar, M. |
PDF |
N/A |
Single cells can resolve graded stimuli |
| 通过K函数分析揭示的细胞竞争的空间和时间特征 |
Day, N. |
PDF |
N/A |
Spatial and temporal signatures of cell competition revealed by K-function analysis |
| 壳聚糖纳米胶囊与非洲鸭脚木提取物对Wistar大鼠的免疫系统具有调节作用 |
Nyuyfoni, G. F. |
PDF |
N/A |
Chitosan nanocapsules with Alstonia boonei extract modulate the immune system in Wistar rats |
| 纳米生理学方法揭示了斑马鱼视网膜双极带状突触中钙微域的多样性 |
Rameshkumar, N. |
PDF |
N/A |
Nanophysiology Approach Revealed Diversity in Calcium Microdomains in Zebrafish Retinal Bipolar Ribbon Synapses |
| 铜宫内节育器对减少母马子宫感染的测试：一项初步研究 |
Gradil, C. |
PDF |
N/A |
The Testing of Copper Intrauterine Devices to Mitigate Uterine Infections in Mares: A Preliminary Study |
| 用于细胞表面交叉光学和化学标记的工具 |
Innes-Gold, S. |
PDF |
N/A |
Tools for intersectional optical and chemical tagging on cell surfaces |
| 可变剪接调节染色质互作组及RIF1 C端结构域的相分离 |
Koo, A. S.-H. |
PDF |
N/A |
Alternative splicing modulates chromatin interactome and phase separation of the RIF1 C-terminal domain |
| LARP4的短保守区域-2与核糖体相关蛋白RACK1相互作用，并促进翻译过程。 |
Ranjan, A. |
PDF |
N/A |
The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation |
| 复制体通过黏连蛋白环的过程 |
Glaser, S. |
PDF |
N/A |
Replisome passage through the cohesin ring |
| 一种新型微型丝状噬菌体作为基因递送载体靶向哺乳动物细胞 |
Wong, S. |
PDF |
N/A |
A novel miniaturized filamentous phagemid as a gene delivery vehicle to target mammalian cells |
| 链球菌噬菌体基因组揭示了广泛的多样性、新的分类学见解以及源自内溶素的全新抗菌肽 |
Mondal, S. I. |
PDF |
N/A |
Streptococcus Phage Genomes Reveal Extensive Diversity, New Taxonomic Insights, and Novel Endolysin-Derived Antimicrobial Peptides |
| 新见解：洛蒙丝孢菌（Lomentospora prolificans）黑色素结构 |
Liporagi Lopes, L. |
PDF |
N/A |
New Insights Into The Melanin Structure Of Lomentospora prolificans |
| EasyAb：一种基于抗体的高通量工作流程，用于与质谱联用的PTM肽富集方法 |
Jayavelu, A. K. |
PDF |
N/A |
EasyAb: A High-Throughput Workflow for Antibody-Based PTM Peptide Enrichment Method Coupled to Mass Spectrometry |
| 高吞吐量活细胞单细胞蛋白质组学 |
Karagach, S. |
PDF |
N/A |
High throughput single-cell proteomics of in-vivo cells |
| 由脂质过氧化产生的N-醛基修饰磷脂酰乙醇胺是N-酰基磷脂酰乙醇胺磷脂酶D的强效底物。 |
Fadaei, R. |
PDF |
N/A |
N-Aldehyde-Modified Phosphatidylethanolamines generated by lipid peroxidation are robust substrates of N-Acyl Phosphatidylethanolamine Phospholipase D |
| 非经典GPCR信号转导在Hedgehog通路中的结构机制 |
Steiner, W. P. |
PDF |
N/A |
A Structural Mechanism for Noncanonical GPCRSignal Transduction in the Hedgehog Pathway |
| 一种定量细胞内肽结合分析揭示了短线性基序的识别决定因素及其上下文依赖性 |
Subbanna, M. S. |
PDF |
N/A |
A quantitative intracellular peptide binding assay reveals recognition determinants and context dependence of short linear motifs |
| 伪GTP酶介导的蛋白质-蛋白质相互作用的结构基础 |
Wang, B. |
PDF |
N/A |
Structural basis of pseudoGTPase-mediated protein-protein interactions |
| 哺乳动物黑视蛋白与拮抗剂AA92593特异性相互作用的分子基础 |
Obayashi, K. |
PDF |
N/A |
Molecular basis underlying specific interaction of mammalian melanopsins with an antagonist AA92593 |
| 通过魔角旋转核磁共振技术获得的噬菌体P22衣壳蛋白在原衣壳中的结构模型 |
Guo, C. |
PDF |
N/A |
Structural Model of Bacteriophage P22 Scaffolding Protein in a Procapsid by Magic-Angle Spinning NMR |
| Notch信号阻断将静息神经干细胞的转录组异质性与它们的再激活途径及潜能联系起来。 |
Morizet, D. |
PDF |
N/A |
Notch signaling blockade links transcriptome heterogeneity in quiescent neural stem cells with their reactivation routes and potential |
| 在物体处理过程中，反馈信号中的高阶和低阶特征具有不同的目标、动态变化和功能 |
Hou, W. |
PDF |
N/A |
Differential destinations, dynamics, and functions of high- and low-order features in the feedback signal during object processing |
| 通过通信子空间在大规模新皮层模型中进行认知网络交互 |
Pereira-Obilinovic, U. |
PDF |
N/A |
Cognitive networks interactions through communication subspaces in large-scale models of the neocortex |
| 病毒载体介导的SLC9A6基因替代减少了Christianson综合征摇晃大鼠模型中的小脑功能障碍 |
Anderson, C. J. |
PDF |
N/A |
Viral vector-mediated SLC9A6 gene replacement reduces cerebellar dysfunction in the shaker rat model of Christianson syndrome |
| 大脑功能连接，而非神经解剖结构，捕捉到了青春期前性别与性别的相互关系。 |
Metoki, A. |
PDF |
N/A |
Brain functional connectivity, but not neuroanatomy, captures the interrelationship between sex and gender in preadolescents |
| 同时对小鼠皮层活动进行介观测量与操控 |
Matveev, P. |
PDF |
N/A |
Simultaneous mesoscopic measurement and manipulation of mouse cortical activity |
| 顺序规划的整合 |
Vikbladh, O. M. |
PDF |
N/A |
Consolidation of Sequential Planning |
| 在SH-SY5Y细胞中DJ-1缺陷揭示了涉及神经功能和疾病的基因和通路网络失调 |
Gock, N. |
PDF |
N/A |
DJ-1 deficiency in SH-SY5Y cells reveals dysregulated networks of genes and pathways involved in neuronal function and disease |
| 线粒体NADK2依赖的NADPH调控人类神经元中Tau寡聚体的摄取 |
Pardo, E. C. |
PDF |
N/A |
Mitochondrial NADK2-dependent NADPH controls Tau oligomer uptake in human neurons |
| 伦敦出租车司机利用区域边界来优化路线选择，并在三十年的时间内提升他们的导航技能。 |
Gahnstrom, C. J. |
PDF |
N/A |
London taxi drivers leverage regional boundaries to optimise route choices and improve their navigation skill across three decades |
| DJ-1 介导帕金森病星形胶质细胞和胶质母细胞瘤细胞中代谢和免疫反应的调控 |
Mencke, P. |
PDF |
N/A |
DJ-1 mediates regulation of metabolism and immune response in Parkinsons disease astrocytes and Glioblastoma cells |
| 急性及早期应激轴调节在关节疾病中能永久性地减轻疼痛和情感共病 |
Hestehave, S. |
PDF |
N/A |
Acute and early stress axis modulation in joint disease permanently reduces pain and emotional comorbidities |
| 两种方法和时间尺度表明，水中珊瑚疾病治疗并未促进抗生素抗性的发展。 |
Neely, K. L. |
PDF |
N/A |
Two methodologies and timescales show no promotion of antibiotic resistance from in-water coral disease treatments |
| 适应性实验室进化产生的耐粘菌素铜绿假单胞菌菌株中，PmrB传感器激酶的适应性权衡及新错义突变的发现 |
Padhy, I. |
PDF |
N/A |
Fitness trade-off and the discovery of a novel missense mutation in the PmrB sensor kinase of a colistin-resistant Pseudomonas aeruginosa strain developed by adaptive laboratory evolution |
| 新型共生生物揭示阿米巴原虫是环境衣原体的重要宿主 |
Liu, F. |
PDF |
N/A |
Novel symbionts reveal amoebae as significant hosts for environmental chlamydiae |
| 利用基于活性的蛋白质谱分析筛选化疗诱导外周神经病变大鼠模型中的潜在生物标志物 |
Miao, H. |
PDF |
N/A |
Screening of potential biomarkers using activity-based protein profiling in a rat model of chemotherapy-induced peripheral neuropathy |
| 季风影响下的两条印度城市河流中抗生素抗性的驱动因素，这些河流接收未经处理的废水 |
Bagra, K. |
PDF |
N/A |
Drivers of antibiotic resistance in two monsoon-impacted Indian urban rivers receiving untreated wastewater |
| 小梁网单细胞分析鉴定出青光眼模型中的线粒体功能障碍，该功能障碍可通过维生素B3治疗得到保护 |
Tolman, N. |
PDF |
N/A |
Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment |
| 利用差示扫描量热法数据对两态蛋白质转变的标准拟合技术的显式推导 |
Priklopil, T. |
PDF |
N/A |
Explicit derivation of the standard fitting technique for two-state protein transitions using differential scanning calorimetry data |
| 动脉平滑肌细胞中自噬介质Parkin的缺乏会加剧腹主动脉瘤的形成。 |
Wang, H. |
PDF |
N/A |
Deficiency of mitophagy mediator Parkin in aortic smooth muscle cells exacerbates abdominal aortic aneurysm |
| 一种基于大肠杆菌的平台，用于环状病毒载体的生产和组装 |
Prakash, R. |
PDF |
N/A |
An E. coli-based platform for the production and assembly of anellovirus vectors |
| 心脏管形态发生受MEF2C调控的节段特异性基因调控网络的调节。 |
Muncie-Vasic, J. M. |
PDF |
N/A |
Heart tube morphogenesis is regulated by segment-specific gene regulatory networks controlled by MEF2C |
| 啮齿动物牙齿发育的多模态表征 |
Jiang, Y. |
PDF |
N/A |
Multi-modal characterization of rodent tooth development |
| 鸟类前肠的延长需要内在和外在细胞行为的协调。 |
Powell, O. |
PDF |
N/A |
Elongation of the nascent avian foregut requires coordination of intrinsic and extrinsic cell behaviors |
| TFAP2C是子宫内滋养层细胞侵袭和深部血绒毛膜胎盘形成的关键调节因子。 |
Dominguez, E. M. |
PDF |
N/A |
TFAP2C is a key regulator of intrauterine trophoblast cell invasion and deep hemochorial placentation |
| 稀疏动物社会网络分析 |
Mylne, H. K. |
PDF |
N/A |
Analysis of sparse animal social networks |
| 通过胞外囊泡非经典分泌自噬相关蛋白VMP1作为胰腺细胞损伤潜在生物标志物 |
Tadic, M. S. |
PDF |
N/A |
UNCONVENTIONAL SECRETION OF THE AUTOPHAGY-RELATED PROTEIN VMP1 VIA EXTRACELLULAR VESICLES AS A POTENTIAL BIOMARKER FOR PANCREATIC CELL INJURY |
| BamE的N端延伸区域协调BamA的β-桶域与BamD之间的相互作用，以实现高效组装。 |
Maruno, Y. |
PDF |
N/A |
The N-terminal extension region of BamE coordinates interaction between the β-barrel domain of BamA and BamD for efficient assembly |
| 基于去稳定剂的细菌微隔室壳体外快速组装与装载方法 |
Range, K. L. |
PDF |
N/A |
A chaotrope-based approach for rapid in vitro assembly and loading of bacterial microcompartment shells |
| 腹侧被盖区与人类的风险厌恶行为之间的功能耦合 |
Lin, W. |
PDF |
N/A |
Habenula-ventral tegmental area functional coupling and risk-aversion in humans |
| 灵长类视网膜输出中的功能多样性 |
Kling, A. |
PDF |
N/A |
Functional diversity in the output of the primate retina |
| 星形胶质细胞控制人类皮层网络中的UP状态和慢振荡周期性 |
Crowe, J. A. |
PDF |
N/A |
Astrocytes control UP state and slow oscillation periodicity in human cortical networks |
| 线粒体应激通过蛋白水解激活PKCδ和Lamin B1磷酸化，在神经元细胞中解构核结构：与年龄相关性神经退行性疾病发病机制的关联 |
Charli, A. |
PDF |
N/A |
Mitochondrial Stress Disassembles Nuclear Architecture through Proteolytic Activation of PKCδ and Lamin B1 Phosphorylation in Neuronal Cells: Implications for Pathogenesis of Age-related Neurodegenerative Diseases |
| 从果蝇连接组到精确的环吸引子动力学 |
Biswas, T. |
PDF |
N/A |
From the fly connectome to exact ring attractor dynamics |
| 雄性和雌性大鼠在精神兴奋剂自我给药行为方面的最显著差异与生物性别无关。 |
Showell, B. H. |
PDF |
N/A |
The most significant differences between male and female rats regarding psychostimulant self-administration behavior are unrelated to biological sex |
| 使用结合通道停用策略和可变数量动态聚焦通道的成人耳蜗植入者的噪音中言语表现 |
Wohlbauer, D. M. |
PDF |
N/A |
Speech in noise performance in adults with cochlear implants using a combined channel deactivation strategy with a variable number of dynamic focused channels |
| 电休克疗法在发作后产生了一股隐秘的浪潮 |
Rosenthal, Z. |
PDF |
N/A |
Electroconvulsive therapy generates a hidden wave after seizure |
| 偏倚校正元分析克服了小脑忽视，以优化小脑行为地形图 |
Magielse, N. |
PDF |
N/A |
Bias-accounting meta-analyses overcome cerebellar neglect to refine the cerebellar behavioral topography |
| 侧化的结状神经节基因表达暗示了胆囊收缩素受体在体内奖励信号传导中的作用 |
Welch, H. F. |
PDF |
N/A |
Lateralized nodose ganglia gene expression implicates cholecystokinin receptors in interoceptive reward signaling |
| 在长期增强过程中，突触前囊泡簇从紧密组织转变为松散组织。 |
Garcia, G. C. |
PDF |
N/A |
The presynaptic vesicle cluster transitions from a compact to loose organization during long-term potentiation |
| Tcf4缺乏导致小鼠反复发作癫痫 |
Craciun, L. |
PDF |
N/A |
Tcf4 Deficiency Causes Recurrent Seizures in Mice |
| 每日电场治疗可改善大鼠胸椎挫伤脊髓损伤后的功能结果 |
Harland, B. |
PDF |
N/A |
Daily electric field treatment improves functional outcomes after thoracic contusion spinal cord injury in rats |
| 神经同步性对于语音理解来说是“足够好”的。 |
Rafferty, M. B. |
PDF |
N/A |
Neural synchrony is "good enough" for speech comprehension |
| 背景很重要：整合NMDA受体功能障碍揭示了在小鼠模型中携带人类患者GluN1变异的有效癫痫治疗方法 |
Venkatesan, S. |
PDF |
N/A |
Context matters: Integrative NMDA receptor dysfunction reveals effective seizure treatment in mice with a human patient GluN1 variant |
| 高效采样PROTAC诱导的三元复合物 |
Zhao, H. |
PDF |
N/A |
Efficient Sampling of PROTAC-Induced Ternary Complexes |
| 母体Med12保护滋养层多能性和胎盘发育 |
Halstead, M. M. |
PDF |
N/A |
Maternal Med12 safeguards trophoblast pluripotency and placental development |
| 钙瞬变调控多纤毛细胞在爪蟾皮肤发育中的上皮整合。 |
Christodoulou, N. |
PDF |
N/A |
Calcium transients regulate epithelial integration of multiciliated cells during Xenopus skin development. |
| RNA结合蛋白Khdrbs1通过剪接调控造血干细胞和祖细胞的出现 |
Karp, I. |
PDF |
N/A |
RNA Binding Protein Khdrbs1 Regulates Hematopoietic Stem and Progenitor Cell Emergence via Splicing |
| 小蜂Nasonia vitripennis中异常巨大的种系决定因子的结构与组成 |
Kemph, A. |
PDF |
N/A |
Novel structure and composition of the unusually large germline determinant of the wasp Nasonia vitripennis |
| 简化胎鼠影像中的不对称量化：基于专家指导的半自动化流程 |
Rolfe, S. M. |
PDF |
N/A |
Streamlining Asymmetry Quantification in Fetal Mouse Imaging: A Semi-Automated Pipeline Supported by Expert Guidance |
| 嗅觉系统中Prok2下游基因的时空调控：从发育到功能 |
Kim, B.-R. |
PDF |
N/A |
Spatiotemporal regulation by downstream genes of Prok2 in olfactory system: from development to function |
| 宿主遗传背景而非环境对扁卷螺（Bulinus truncatus）的微生物群构成具有更大影响，扁卷螺是血吸虫属物种的中间宿主。 |
Jaquet, M. J. |
PDF |
N/A |
Evidences that host genetic background more than the environment shapes the microbiota of the snail Bulinus truncatus, an intermediate host of Schistosoma species. |
| 鲸鱼语言模型：利用机器学习在抹香鲸的声音和行为中寻找结构与信息 |
Sharma, P. |
PDF |
N/A |
WhaleLM: Finding Structure and Information in Sperm Whale Vocalizations and Behavior with Machine Learning |
| 通过mRNA递送对人类造血干细胞进行体内基因编辑以治疗血液疾病 |
Xu, S. |
PDF |
N/A |
In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery |
| 系统性剖析正常乳腺组织中的表观遗传年龄加速现象，揭示其与雌激素信号传导及癌症风险的关联 |
Sehl, M. E. |
PDF |
N/A |
Systematic dissection of epigenetic age acceleration in normal breast tissue reveals its link to estrogen signaling and cancer risk |
| 抗寄生虫苯二氮卓类药物美克洛嗪对曼氏血吸虫转录表型的影响 |
Henthorn, C. R. |
PDF |
N/A |
Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke Schistosoma mansoni |
| 全鼠肾小球纳米级光学成像、重建与空间分析 |
Ali, A. |
PDF |
N/A |
Nanoscale Optical Imaging, Reconstruction, and Spatial Analysis of Whole Mouse Glomeruli |
| 拟议的普遍存在于超微细菌门Patescibacteriota phyl. nov.中的新属Patescibacterium danicum gen. nov., sp. nov. |
Dutkiewicz, Z. |
PDF |
N/A |
Proposal of Patescibacterium danicum gen. nov., sp. nov. in the ubiquitous ultrasmall bacterial phylum Patescibacteriota phyl. nov. |
| 精氨酸及其代谢在TGF-β诱导的肺成纤维细胞激活中的作用 |
Hamanaka, R. B. |
PDF |
N/A |
Role of Arginine and its Metabolism in TGF-β-Induced Activation of Lung Fibroblasts |
| 互养网络结构影响生长抑制压力下的微生物群落多样性 |
Newton, D. P. |
PDF |
N/A |
The network structure of cross-feeding impacts microbial community diversity under growth-inhibiting stresses |
| 结合系统发育和地理数据可以高度准确地预测植物-害虫相互作用 |
Hernandez-Gutierrez, E. |
PDF |
N/A |
Combined phylogenetic and geographic data can predict plant-pest interactions with high accuracy |
| 三萜环化酶的进化历史和现代多样性 |
McShea, H. |
PDF |
N/A |
The evolutionary history and modern diversity of triterpenoid cyclases |
| 古代二倍体栽培棉种草棉（Gossypium herbaceum L.）和亚洲棉（G. arboreum L.）的传播模式对比 |
Viot, C. R. |
PDF |
N/A |
Contrasting dissemination patterns of diploid cultivated cotton species Gossypium herbaceum L. and G. arboreum L. in Antiquity |
| 在宿主多样化的环境中克雷伯氏菌噬菌体的进化策略 |
Ferriol-Gonzalez, C. |
PDF |
N/A |
Evolutionary strategies of Klebsiella phages in a host-diverse environment |
| 基因组证据表明，蝾螈中的平衡致死系统起源于一次瞬间的物种形成事件。 |
France, J. M. |
PDF |
N/A |
Genomic evidence suggests the balanced lethal system in Triturus newts originated in an instantaneous speciation event. |
| 特质冗余和信息内容对人类系统发育推断的影响 |
Raskin, L. Y. |
PDF |
N/A |
The effects of trait redundancy and information content on hominin phylogenetic inference |
| 入侵阿根廷蚁（Linepithema humile）的群体基因组学——尽管遗传多样性低，引入的超群体中仍存在适应性进化 |
Holmberg, I. |
PDF |
N/A |
Population Genomics of the Invasive Argentine Ant (Linepithema humile) - Adaptive Evolution in the Introduced Supercolonies Despite Low Genetic Diversity |
| 巢寄生中的极端疲劳抗性类似于与宿主之间的乞食竞争中的消耗战 |
Antonson, N. D. |
PDF |
N/A |
Extreme fatigue-resistance in a brood parasite parallels a war of attrition in begging competition with hosts |
| 合成USC-093及其对映体前体USC-093D在体外及叙利亚仓鼠模型中对抗腺病毒的效果比较 |
Yang, J. |
PDF |
N/A |
Synthesis of USC-093 and comparison with its promoiety enantiomer USC-093D against adenovirus in vitro and in a Syrian hamster model |
| 吸收分子使活体小鼠的腹部和背部都变得透明 |
TIE, X. |
PDF |
N/A |
Absorbing molecules make both abdomen and back transparent in live mice |
| PMAIP1介导的葡萄糖代谢及其对乳腺癌肿瘤微环境的影响：多组学分析与实验验证的整合 |
Zhang, Y. |
PDF |
N/A |
PMAIP1-Mediated Glucose Metabolism and its Impact on the Tumor Microenvironment in Breast Cancer: Integration of Multi-Omics Analysis and Experimental Validation |
| 通过注意力增强的表征学习探索表型相关的单细胞 |
Wu, Q. |
PDF |
N/A |
Exploring phenotype-related single-cells through attention-enhanced representation learning |
| TeloSearchLR：一种利用长序列读取检测新端粒重复基序的算法 |
Chung, G. |
PDF |
N/A |
TeloSearchLR: an algorithm to detect novel telomere repeat motifs using long sequencing reads |
| FOXM1调控血小板诱导的胰腺癌细胞失巢凋亡抵抗 |
Ernesti, A. |
PDF |
N/A |
FOXM1 regulates platelet-induced anoikis resistance in pancreatic cancer cells |
| 细菌无细胞DNA分析显示，疑似败血症的新生马驹中多种细菌共同升高 |
Chen, L.-T. |
PDF |
N/A |
Bacterial cell-free DNA profiling reveals co-elevation of multiple bacteria in newborn foals with suspected sepsis |
| 基于微针的DNA提取实现无损种子基因型鉴定 |
Li, M. |
PDF |
N/A |
Nondestructive Seed Genotyping via Microneedle-Based DNA Extraction |
| DANGEROUS MIX 3（一种α/β水解酶）触发植物中NLR介导的遗传不相容性的结构决定因素 |
Kim, G. |
PDF |
N/A |
Structure determinants of DANGEROUS MIX 3, an alpha/beta hydrolase, for triggering NLR-mediated genetic incompatibility in plants |
| 基于基因的适应性和碳同化能力在不同大果栎种群间的变异 |
Rea, L. M. S. |
PDF |
N/A |
Genetically based variation in fitness and carbon assimilation among bur oak populations |
| NuclampFISH技术能够基于核RNA表达进行细胞分选，以用于染色质分析。 |
Liu, Y. |
PDF |
N/A |
NuclampFISH enables cell sorting based on nuclear RNA expression for chromatin analysis |
| 分享聚光灯：揭示跨物种的共同注意力动态 |
Glukhova, M. |
PDF |
N/A |
Sharing the Spotlight: Uncovering common attentional dynamics across species |
| SenSeqNet：一种基于深度学习的蛋白质序列细胞衰老检测框架 |
Jiang, H. |
PDF |
N/A |
SenSeqNet: A Deep Learning Framework for Cellular Senescence Detection from Protein Sequences |
| TILLCANN：一种用于大麻（Cannabis sativa）突变发现和作物改良的TILLING平台 |
Duarte-Delgado, D. |
PDF |
N/A |
TILLCANN: A TILLING platform in Cannabis sativa for mutation discovery and crop improvement |