| 多能干细胞的多谱系分化图谱揭示了TMEM88作为哺乳动物血压发育调节因子的作用 |
Shen, S. |
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N/A |
A pluripotent stem cell atlas of multilineage differentiation reveals TMEM88 as a developmental regulator of mammalian blood pressure |
| 进化上多样化的穴样内陷蛋白共享一个围绕两亲性盘状结构构建的共同结构框架 |
Han, B. |
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N/A |
Evolutionarily diverse caveolins share a common structural framework built around amphipathic discs |
| 利用神经风格迁移研究动物信号设计的演变：以一种装饰性鱼类为例 |
Hejja-Brichard, Y. |
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N/A |
Using Neural Style Transfer to study the evolution of animal signal design: A case study in an ornamented fish |
| 动粒蛋白KNL-1调控肌动蛋白细胞骨架以控制树突分支 |
Domingos, H. A. |
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N/A |
The Kinetochore Protein KNL-1 Regulates the Actin Cytoskeleton to Control Dendrite Branching |
| 图拉普拉斯谱、拓扑性质以及结构脑网络的高阶相互作用具有个体特异性、可重复性，但高度依赖于图构建方案。 |
Dimitriadis, S. I. |
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N/A |
Graph Laplacian Spectrum, topological properties, and high-order interactions of Structural Brain Networks are Subject-Specific, Repeatable but Highly Dependent on Graph Construction Scheme |
| 从足月人胎盘中发现的多能细胞类型 |
Vadakke-Madathil, S. |
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N/A |
Discovery of a multipotent cell type from the term human placenta |
| 利用动态因果推断识别促进癌症进展的合作基因 |
Cifuentes Bernal, A. |
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N/A |
Identifying cooperative genes causing cancer progression with dynamic causal inference |
| 神经纤毛蛋白-1通过旁分泌调节内皮粘附连接来控制血管通透性 |
Pal, S. |
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N/A |
Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions |
| 用于肝毒性检测的再生人肝类器官（HLOs）在柱状/灌流板中 |
Shrestha, S. |
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N/A |
Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assays |
| 演变为混沌——传播性与免疫逃逸之间权衡的含义 |
Sayyar, G. |
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N/A |
Evolution into chaos - implications of the trade-off between transmissibility and immune evasion |
| 蛋白质序列和结构的标记化和连续嵌入压缩 |
Lu, A. X. |
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N/A |
Tokenized and Continuous Embedding Compressions of Protein Sequence and Structure |
| 异戊二烯通过启动植物激素反应来驱避植食性昆虫。 |
Sahu, A. |
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N/A |
Isoprene deters insect herbivory by priming plant hormone responses |
| 从共进化动态耦合的图分析中提取的功能重要残基 |
Xu, M. |
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N/A |
Functionally Important Residues from Graph Analysis of Coevolved Dynamic couplings |
| 酵母线粒体中COX1 mRNA翻译激活机制的深入研究 |
Zamudio-Ochoa, A. |
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N/A |
Insights into the Translational Activation Mechanisms of the COX1 mRNA in Yeast Mitochondria |
| Clytia的口面细胞类型与珊瑚幼虫具有共同特征，并将牛磺酸与定殖的调控联系起来。 |
Ramon-Mateu, J. |
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N/A |
Aboral cell types of Clytia and coral larvae have shared features and link taurine to the regulation of settlement |
| 通过体内mRNA递送实现抗原特异性T细胞免疫疗法 |
Su, F.-Y. |
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N/A |
Antigen-specific T cell immunotherapy by in vivo mRNA delivery |
| 蛋白质亚细胞定位预测的深度生成模型 |
Yang, L. |
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N/A |
Deep generative model for protein subcellular localization prediction |
| 蛋白质亚细胞定位预测的深度生成模型 |
Yuan, G.-H. |
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N/A |
Deep generative model for protein subcellular localization prediction |
| 使用Pythia-PPI可靠地预测蛋白质-蛋白质结合亲和力在突变后的变化 |
Tao, F. |
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N/A |
Reliable prediction of protein-protein binding affinity changes upon mutations with Pythia-PPI |
| 畸变校正拼接器：集成光学畸变校正的显微图像拼接 |
Cang, H. |
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N/A |
DistortCorrect Stitcher: Microscopy Image Stitching with Integrated Optical Distortion Correction |
| RvD1 和 LXA4 对心脏电压门控钾通道的抑制作用 |
de la Cruz, A. |
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N/A |
RvD1 and LXA4 inhibitory effects on cardiac voltage-gated potassium channels |
| 具有高级基因组特征的自我认证基因组材料 |
Wang, Z. |
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N/A |
Self-Authenticating Genomic Materials with Advanced Genome Signatures |
| 沙门氏菌效应蛋白SseL通过β-连环蛋白信号轴诱导PD-L1上调和T细胞失活 |
Chopra, U. |
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N/A |
Salmonella effector SseL induces PD-L1 up-regulation and T cell inactivation via beta-catenin signalling axis |
| SloR-SRE与S. mutans mntH启动子的结合具有协同性。 |
Ziogas, M. |
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N/A |
SloR-SRE binding to the S. mutans mntH promoter is cooperative. |
| 一种高通量蛋白质标记工具包，保留了内源性UTR，用于研究动质体中的基因调控。 |
Carbajo, C. G. |
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N/A |
A high-throughput protein tagging toolkit that retains endogenous UTRs for studying gene regulation in Kinetoplastids. |
| 牙形石牙齿基质蛋白1指导石鳖牙齿中的氧化铁沉积 |
Nemoto, M. |
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N/A |
Radular teeth matrix protein 1 directs iron oxide deposition in chiton teeth |
| 小鼠粗线期piRNA切割数百个转录本，但仅改变少数靶标的稳态丰度 |
Cecchini, K. |
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N/A |
Mouse Pachytene piRNAs Cleave Hundreds of Transcripts,But Alter the Steady-State Abundance of Only a Minority of Targets |
| CELF2通过铰链域介导的核凝聚促进tau外显子10的包含 |
Li, X. |
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N/A |
CELF2 promotes tau exon 10 inclusion via hinge domain-mediated nuclear condensation |
| 秋水仙碱抑制小鼠平滑肌细胞表型转换及主动脉夹层 |
Jiang, H. |
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N/A |
Colchicine Inhibits Smooth Muscle Cell Phenotypic Switch and Aortic Dissection in Mice |
| 发育中的小鼠腭单细胞图谱揭示了表皮细胞命运的细胞和分子转变 |
Huang, W. |
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N/A |
Single-cell atlas of developing mouse palates reveals cellular and molecular transitions in periderm cell fate |
| CCR9信号终止受一种不依赖于arrestin的磷酸化机制调控。 |
Lamme, T. D. |
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N/A |
CCR9 signal termination is governed by an arrestin-independent phosphorylation mechanism |
| 模拟膜热蛋白质组分析（MM-TPP）用于绘制膜蛋白-配体动力学图谱 |
Jandu, R. S. |
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N/A |
Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamics |
| 通过生化重建揭示的DNA复制叉稳定和重启机制 |
Canal, B. |
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N/A |
DNA replication fork stabilization and restart mechanisms revealed by biochemical reconstitution |
| 通过增强Wnt/β-catenin信号通路和下调TGF-β/Samd/BMP信号通路，硝酸盐促进C57BL/6小鼠毛发生长 |
Lan, Y. |
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N/A |
Nitrate Promoting Hair Growth Through Enhancing Wnt/β-catenin and Downregulating TGF-β/Samd/BMP signaling pathway in C57BL/6 Mice |
| 一种评估癌症多药耐药性的定量方法 |
Ray, A. E. |
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N/A |
A Quantitative Approach for Assessing Multidrug Resistance in Cancer |
| 使用工程化重组酶将特定DNA插入人类基因组 |
Fanton, A. |
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N/A |
Site-specific DNA insertion into the human genome with engineered recombinases |
| BC-设计：一种高精度逆蛋白质折叠的生物化学感知框架 |
Tang, X. |
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N/A |
BC-Design: A Biochemistry-Aware Framework for High-Precision Inverse Protein Folding |
| 衰老生物标志物的公开竞赛 |
Ying, K. |
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N/A |
An Open Competition for Biomarkers of Aging |
| 代谢调控RNA甲基化由m6A阅读器IGF2BP3介导 |
Sharma, G. |
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N/A |
Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3 |
| 核仁中前rRNA的空间分布与功能组织 |
Pan, Y.-H. |
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N/A |
Pre-rRNA spatial distribution and functional organization of the nucleolus |
| 由HSF1调控的蛋白质稳态网络增强的显性负性TP53突变 |
Sebastian, R. M. |
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N/A |
Dominant-negative TP53 mutations potentiated by the HSF1-regulatedproteostasis network |
| 纽蛋白Y822磷酸化调控心肌细胞粘附动力学及心脏中粘着连接的成熟过程 |
Li, X. |
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N/A |
Vinculin Y822 phosphorylation regulates cardiomyocyte adhesion dynamics and adherens junction maturation in the heart |
| PNPLA3-I148M是一种新形态，干扰了两种主要的肝甘油三酯清除途径。 |
Sherman, D. J. |
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N/A |
PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways |
| 资源波动下多物种共存的一个统一原则 |
Richardson, J. A. |
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N/A |
A unifying principle for multispecies coexistence under resource fluctuations |
| PreDigs：一个针对消化细胞注释的特定上下文细胞类型标记和精确细胞亚型的数据库 |
Meng, J. |
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N/A |
PreDigs: a Database of Context-specific Cell-type Markers and Precise cell subtypes for Digestive Cell Annotation |
| 长读长纳米孔全基因组eDNA测序用于河流生物多样性、污染和环境健康监测 |
Nousias, O. |
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N/A |
Long-read nanopore shotgun eDNA sequencing for river biodiversity, pollution and environmental health monitoring |
| 将铁氧还蛋白-NADP+还原酶连接到光系统I上促进了光合循环电子传递 |
Emrich-Mills, T. Z. |
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N/A |
Tethering ferredoxin-NADP+ reductase to photosystem I promotes photosynthetic cyclic electron transfer |
| 核篮的解离会引发衰老酵母中的染色体丢失 |
Mirkovic, M. |
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N/A |
Dissociation of the nuclear basket triggers chromosome loss in aging yeast |
| 剪接体成分GAMETOPHYTIC FACTOR 1（GFA1）调控关键的光周期转换 |
Tiedemann, S. |
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N/A |
The spliceosomal component GAMETOPHYTIC FACTOR 1 (GFA1) regulates a key photoperiodic switch |
| 开发一种用于EV定量的ELISA检测方法，以辅助大规模EV生产 |
Zhou, X. |
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N/A |
Development of an ELISA assay for EV quantification to assist the large-scale EV manufacture |
| 微生物组使N-酰基脂质池多样化——包括由短链脂肪酸衍生的化合物。 |
Mannochio-Russo, H. |
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N/A |
The microbiome diversifies N-acyl lipid pools - including short-chain fatty acid-derived compounds |
| 血小板在早期腹主动脉瘤形成中具有保护作用 |
Russell, H. M. |
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N/A |
Platelets are Protective in Early Abdominal Aortic Aneurysm Formation |
| 高温下植物亚细胞碳水化合物代谢 |
Seydel, C. |
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N/A |
Subcellular plant carbohydrate metabolism under elevated temperature |
| 叶黄素循环在海水藻类Nannochloropsis oceanica中平衡了光保护与光合效率 |
Michelberger, T. |
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N/A |
The Xanthophyll Cycle balances Photoprotection and Efficiency in the seawater alga Nannochloropsis oceanica |
| 许多转录因子家族在植物中具有进化上保守的结合基序 |
Zenker, S. |
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N/A |
Many transcription factor families have evolutionarily conserved binding motifs in plants |
| A型和C型响应调节基因对水稻生长和穗部结构有积极影响 |
Rong, C. |
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N/A |
Positive impact of Type-A and -C response regulator genes on growth and panicle architecture in rice |
| 一种新型顺铂类前药抑制赖氨酸去乙酰化酶，抑制核苷酸切除修复，并克服耐药性 |
Negev Korem, Y. |
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N/A |
A Novel Cisplatin-Based Prodrug Inhibits Lysine Deacetylases, Suppresses Nucleotide Excision Repair, and Overcomes Resistance |
| 草莓（Fragaria x ananassa）中抗疫霉菌2（RPc2）位点的基因组结构 |
Han, H. |
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N/A |
Genomic Architecture of the Resistance to Phytophthora Cactorum 2 (RPc2) Locus in Strawberry (Fragaria x ananassa) |
| 草莓（Fragaria x ananassa）中抗疫霉菌2（RPc2）位点的基因组结构 |
Han, H. |
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N/A |
Genomic Architecture of the Resistance to Phytophthora Cactorum 2 (RPc2) Locus in Strawberry (Fragaria x ananassa) |
| 肾小管上皮细胞中的DNA损伤反应需要nephronophthisis蛋白GLIS2/NPHP7 |
Ebert, L. K. |
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N/A |
The nephronophthisis protein GLIS2/NPHP7 is required for the DNA damage response in kidney tubular epithelial cells |
| 肠道干细胞通过凋亡小体吞噬作用增强局部黏膜免疫 |
Zhou, J. Y. |
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N/A |
Intestinal stem cells enhance local mucosal immunity through apoptotic body phagocytosis |
| 半合成铁蛋白纳米笼用于灵活、位点特异性靶向、簇形成及膜受体激活 |
Neusch, A. |
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N/A |
Semisynthetic Ferritin Nanocages for Flexible, Site-specific Targeting, Cluster-formation and Activation of Membrane Receptors |
| 人类细胞中依赖于检查点的DNA复制叉稳定机制 |
Bertolin, A. P. |
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N/A |
The mechanism of checkpoint-dependent DNA replication fork stabilization in human cells |
| 突触间隙的几何结构通过调节神经递质停留时间来影响NMDAR开放概率 |
Hernandez Mesa, M. |
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N/A |
Synaptic cleft geometry modulates NMDAR opening probability by tuning neurotransmitter residence time |
| 一种协调的激酶和磷酸酶网络调控Stu2招募至酵母动粒 |
Stewart, M. G. |
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N/A |
A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores |
| 在3D BCI控制的伸手适应过程中，猴子的前额叶和顶叶皮层中的运动参考框架内的计划和运动活动共同适应 |
Ferrea, E. |
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N/A |
Planning and movement activities co-adapt in a motor-reference frame during 3D BCI-controlled reach adaptation in monkey frontal and parietal cortices |
| 两种视觉运动适应的学习方式 |
Zhang, Y. |
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N/A |
Two ways to learn in visuomotor adaptation |
| 抑制α7 nAChR活性在脆性X综合征小鼠模型中导致听源性癫痫发作和过度活跃 |
Goebel, S. |
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N/A |
Dampened α7 nAChR activity contributes to audiogenic seizures and hyperactivity in a mouse model of Fragile X Syndrome |
| 研究在轻微足底电击应激后，基因标记的杏仁核神经元中c-Fos的变化 |
Dong, H. |
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N/A |
Investigate c-Fos changes in genetically identified amygdala neurons after mild footshock stress |
| CX3CR1-BAC-Cre的组成型表达在微胶质细胞中引入最小的脱靶效应 |
Mroue-Ruiz, F. H. |
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N/A |
Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects in microglia |
| 产前接触δ-9-四氢大麻酚对小鼠大脑发育的影响：一项从胎儿到成年的磁共振成像研究 |
Cupo, L. |
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N/A |
Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study |
| 睡眠中断改善了简单嗅觉和视觉决策任务中的表现 |
Pflitsch, P. |
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N/A |
Sleep Disruption Improves Performance in Simple Olfactory and Visual Decision-Making Tasks |
| 策略优化源于噪声表示学习 |
Brenner, J. W. |
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N/A |
Policy optimization emerges from noisy representation learning |
| 快速眼动睡眠在海马体中记忆的神经分化过程中所起的作用 |
McDevitt, E. A. |
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N/A |
The role of REM sleep in neural differentiation of memories in the hippocampus |
| 轻度局部冷却可选择性地影响树突树中的计算过程 |
Matin, M. H. |
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N/A |
Mild focal cooling selectively impacts computations in dendritic trees |
| 计算建模显示了支持意识的感觉和前额叶理论的证据。 |
Bandara, K. H. |
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N/A |
Computational modelling shows evidence in support of both sensory and frontal theories of consciousness |
| 关于心智游移和动态思维的神经基础：一项药物和脑刺激研究 |
Rasmussen, T. |
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N/A |
On the neural substrates of mind wandering and dynamic thought: A drug and brain stimulation study |
| 外侧缰核中的神经元-星形胶质细胞耦合介导了抑郁样行为 |
Xin, Q. |
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N/A |
Neuron-astrocyte Coupling in Lateral Habenula Mediates Depressive-like Behaviors |
| 一种双向的脑-脂肪体轴用于病原体规避 |
Wang, Y. |
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N/A |
A Bidirectional Brain-Fat Body Axis for Pathogen Avoidance |
| 新生儿脑室内出血后侧脑室纤毛功能障碍不会导致基于纤毛的脑脊液流动网络的功能变化。 |
Pan, S. |
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N/A |
Cilia dysfunction in the lateral ventricles after neonatal intraventricular hemorrhage does not lead to functional changes in cilia-based CSF flow networks |
| 锥体细胞类型和5-HT2A受体对于赛洛西宾持久药效的发挥至关重要 |
Shao, L.-X. |
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N/A |
Pyramidal cell types and 5-HT2A receptors are essential for psilocybin's lasting drug action |
| 睾丸中体细胞性别认同的转变会引发体细胞中雌性特异性的细胞行为，并在生殖细胞中诱导早期卵母细胞的特化。 |
Roach, T. V. |
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N/A |
Conversion of somatic sex identity in the testis induces female-specific cellular behaviors in the soma and early oocyte specification in the germline |
| 量化生物模式形成的复杂性：通过复杂性度量的新视角 |
Riedel, J. H. R. |
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N/A |
Quantifying the intricacies of biological pattern formation: A new perspective through complexity measures |
| 长寿保障基因LAG1和LAC1在调节酿酒酵母内质网应激和脂质稳态中的不同作用 |
MATHIVANAN, A. |
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N/A |
Differential Roles of Longevity Assurance Genes LAG1 and LAC1 in Regulating Endoplasmic Reticulum stress and Lipid Homeostasis in Saccharomyces cerevisiae |
| 相分离解决与生长相关的电路故障 |
Zhang, R. |
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N/A |
Phase Separation to Resolve Growth-Related Circuit Failures |
| 高通量开发和表征用于人细胞基因调控和表观遗传控制的新型功能性纳米抗体 |
Wan, J. |
PDF |
N/A |
High-throughput development and characterization of new functional nanobodies for gene regulation and epigenetic control in human cells |
| 纹状体胆碱能中间神经元的同步激活可诱导局部血清素释放 |
Matityahu, L. |
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N/A |
Synchronous activation of striatal cholinergic interneurons induces local serotonin release |
| 小鼠血吸虫病中的血小板减少症与肝脏巨噬细胞摄取血小板有关，这些巨噬细胞具有独特的激活表型。 |
Greenman, J. H. |
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N/A |
Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype |
| 神经毒性和非神经毒性HIV-1菌株及其Tat蛋白诱导不同的细胞因子-趋化因子谱 |
Rao, V. R. |
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N/A |
Neurovirulent and non-neurovirulent strains of HIV-1 and their Tat proteins induce differential cytokine-chemokine profiles |
| 评估鞋类作为媒介传播意外感染源给小鼠的生物安全风险 |
Palillo, M. B. |
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N/A |
Assessing the Biosecurity Risk of Footwear as a Fomite for Transmission of Adventitious Infectious Agents to Mice |
| 在感染过程中，巨噬细胞会产生一种名为甲基乙二醛的抗菌效应分子。 |
Anaya-Sanchez, A. |
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N/A |
Methylglyoxal is an antibacterial effector produced by macrophages during infection |
| Progerin的积累导致了Hutchinson-Gilford早衰综合征中主动脉平滑肌细胞的丧失 |
Kim, P. H. |
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N/A |
The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome |
| 慢性压力会阻碍应激颗粒的形成 |
Adachi, Y. |
PDF |
N/A |
Chronic stress antagonizes formation of Stress Granules |
| 解释不同分类水平上土壤细菌群落结构的非生物和生物因素的相对影响 |
Mayjonade, B. |
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N/A |
The relative effects of abiotic and biotic factors in explaining the structure of soil bacterial communities at diverse taxonomic levels |
| 同域分布的Stichopus cf. horrens（棘皮动物门：刺参科）种群基因组分化：基于SNP标记对生殖隔离的见解 |
Kim, K. M. |
PDF |
N/A |
Genomic divergence of sympatric lineages within Stichopus cf. horrens (Echinodermata: Stichopodidae): Insights on reproductive isolation inferred from SNP markers |
| 野生鸟类中的卵激素是否具有适应性后果？一项系统综述与元分析 |
Mentesana, L. |
PDF |
N/A |
Do egg hormones have fitness consequences in wild birds? A systematic review and meta-analysis |
| 物种共存性在占用模型中能被可靠地推断出来吗？ |
Louvrier, J. |
PDF |
N/A |
How reliably can species co-occurrence be inferred from occupancy models? |
| FIGNL1通过解离RAD51纤维，在BRCA2缺陷细胞中抑制同源重组 |
Kuthethur, R. |
PDF |
N/A |
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments |
| 使用原始模板定向扩增技术对胚泡活检标本进行精确的全外显子组分析 |
Samitova, A. |
PDF |
N/A |
PRECISE EXOME ANALYSIS OF BLASTOCYST BIOPSY SCALE SAMPLES USING PRIMARY TEMPLATE-DIRECTED AMPLIFICATION |
| 将编码变异等位基因系列测试扩展到汇总统计数据 |
McCaw, Z. R. |
PDF |
N/A |
Extending the Coding-variant Allelic Series Test to Summary Statistics |
| JNK的阈值水平通过JAK/STAT激活损伤响应增强子，促进组织再生 |
Quinn, J. W. |
PDF |
N/A |
A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration |
| 细菌工程活体材料调节哺乳动物细胞的力学信号传导 |
Ostmann, K. |
PDF |
N/A |
Bacterial Engineered Living Materials modulate Mechanosignaling in Mammalian Cells |
| 使用isONclust3对大规模长读长转录组数据进行从头聚类 |
Petri, A. J. |
PDF |
N/A |
De novo clustering of extensive long-read transcriptome datasets with isONclust3 |
| MARVEL：通过监督图对比学习进行微环境注释 |
CUI, Y. |
PDF |
N/A |
MARVEL: Microenvironment Annotation by Supervised Graph Contrastive Learning |
| 通过热点引导的生成式深度学习进行类药物PPI抑制剂的靶向设计 |
Sun, H. |
PDF |
N/A |
Target-specific design of drug-like PPI inhibitors via hot-spot-guided generative deep learning |
| drMD：面向实验学家的分子动力学 |
Shrimpton-Phoenix, E. |
PDF |
N/A |
drMD: Molecular Dynamics for Experimentalists |
| Kaizen：使用VQ-VAE分解细胞图像 |
Majoral, D. |
PDF |
N/A |
Kaizen: Decomposing cellular images with VQ-VAE |
| 使用机器学习预测延长小鼠寿命的化学化合物 |
Belikov, A. V. |
PDF |
N/A |
Predicting Mouse Lifespan-Extending Chemical Compounds with Machine Learning |
| 多上下文种子能够实现快速且高精度的读取映射 |
Tolstoganov, I. |
PDF |
N/A |
Multi-context seeds enable fast and high-accuracy read mapping |
| IPMN的空间转录组学揭示了不同惰性和恶性谱系 |
Iyer, M. K. |
PDF |
N/A |
Spatial Transcriptomics of IPMN Reveals Divergent Indolent and Malignant Lineages |
| TACSTD2表达标志着结肠腺瘤的早期转变 |
Siskova, A. |
PDF |
N/A |
TACSTD2 expression marks the early transition to colon adenomas |
| 使用CSI-TME识别IDH突变型胶质瘤肿瘤微环境中具有预后意义的细胞状态相互作用 |
Singh, A. |
PDF |
N/A |
Identifying Prognostic Cell State Interactions in the TumorMicroenvironment of IDH-Mutant Gliomas Using CSI-TME |
| 单细胞AML图谱揭示了t(8;21) AML中与年龄相关的基因调控网络 |
Whittle, J. |
PDF |
N/A |
Single-Cell Atlas of AML Reveals Age-Related Gene Regulatory Networks in t(8;21) AML |
| 在一组新型的EGFR酪氨酸激酶抑制剂适应性非小细胞肺癌细胞系中的表型可塑性 |
Nanthaprakash, T. |
PDF |
N/A |
Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor-adapted non-small cell lung cancer cell lines |
| 外源性ephrin-A3给药恢复了孕激素处理小鼠的阴道上皮屏障功能 |
Liu, M. |
PDF |
N/A |
Exogenous ephrin-A3 administration restores vaginal epithelial barrier function in progestin-treated mice |
| 金雕定期利用重力波在阿尔卑斯山翱翔：高分辨率气象数据带来的新见解 |
Carrard, T. |
PDF |
N/A |
Golden eagles regularly use gravity waves to soar in the Alps: new insights from high-resolution weather data |
| 巢或不巢：印度奥里萨邦橄榄海龟大规模筑巢事件的环境提示 |
Srikanthan, P. |
PDF |
N/A |
To nest or not to nest: environmental cues for olive ridley mass nesting events in Odisha, India |
| 一种简易且经济高效的微流控装置，采用三维交叉流T型接头生成脱细胞的细胞外基质衍生微载体 |
Kamar, F. |
PDF |
N/A |
A simple, cost-effective microfluidic device using a 3D cross-flow T-junction for producing decellularized extracellular matrix-derived microcarriers |
| 基于聚酮合成的多元醇、氨基醇和羟基酸生物合成平台 |
Dan, Q. |
PDF |
N/A |
A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxyacids |
| HMGB1介导了巨噬细胞的招募，并在损伤后导致区域性椎间盘组织的生理和力学特性发生改变。 |
Burt, K. G. |
PDF |
N/A |
HMGB1 mediates macrophage recruitment and regional intervertebral disc tissue functional and mechanical property changes following injury. |
| BLOC：可构建和可连接的芯片上器官 |
Kimura, Y. |
PDF |
N/A |
BLOC: buildable and linkable organ on a chip |
| 从多能干细胞中可调的人CD4+和CD8+ T细胞的差异化 |
Jones, R. D. |
PDF |
N/A |
Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells |
| 综合无偏分析加速动脉粥样硬化中血管组织变化的高分辨率超声结合光声成像技术 |
de Jong, A. |
PDF |
N/A |
Comprehensive Unbiased Analysis of Vascular Tissue Changes in Accelerated Atherosclerosis Using High-Resolution Ultrasound combined with Photoacoustic Imaging |
| GeneCover：一种无标签标记基因选择的组合方法 |
Wang, A. |
PDF |
N/A |
GeneCover: A Combinatorial Approach for Label-free Marker Gene Selection |
| 从超级字符串到索引：利用掩码Burrows-Wheeler变换（MBWT）为无约束k-mer集合构建空间高效索引 |
Sladky, O. |
PDF |
N/A |
FroM Superstring to Indexing: a space-efficient index for unconstrained k-mer sets using the Masked Burrows-Wheeler Transform (MBWT) |
| 通过单细胞和空间转录组学在轻度IgA肾病肾小球内皮细胞中鉴定的炎症分子 |
Hasegawa, K. |
PDF |
N/A |
Inflammatory molecules in the glomerular endothelium in mild IgA-Nephropathy identified by single-cell and spatial transcriptome |
| cOmicsArt - 一个可定制的组学分析与报告工具 |
Seep, L. |
PDF |
N/A |
cOmicsArt - a customizable Omics Analysis and reporting tool |
| 病理学中人工智能模型的反事实扩散模型用于机制可解释性 |
Zigutyte, L. |
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N/A |
Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology |
| 在连锁不平衡不匹配的情况下进行稳健的精细定位 |
Zhang, W. |
PDF |
N/A |
Robust fine-mapping in the presence of linkage disequilibrium mismatch |
| 多组学分析揭示了CMTR1在癌症中的上调及其在核糖体蛋白基因表达和肿瘤生长中的作用 |
Campeanu, I. J. |
PDF |
N/A |
Multi-omics analysis reveals CMTR1 upregulation in cancer and roles in ribosomal protein gene expression and tumor growth |
| 一种新型体外AML骨髓微环境模型揭示CD44和粘着斑激酶为逆转细胞粘附介导的药物抵抗的治疗靶点 |
Ladikou, E. E. |
PDF |
N/A |
A novel in-vitro model of the bone marrow microenvironment in AML identifies CD44 and Focal Adhesion Kinase as therapeutic targets to reverse cell adhesion-mediated drug resistance |
| 关键的分析参数有助于在从组织中提取的RNA中自信地检测表达变化、融合和短变异 |
Kubik, S. |
PDF |
N/A |
Critical assay parameters facilitating confident detection of expression changes, fusions and short variants in RNA isolated from tissue |
| 选择具有高生产潜力且对黑果病（BPR）和霜冻果病（FPR）具有耐受性的可可克隆品种。 |
Lopez, M. |
PDF |
N/A |
Selecting cacao clones with high productivity potential and tolerance to Black Pod Rot (BPR) and Frosty Pod Rot (FPR). |
| 人类肾小球中拓扑结构不同但功能等效的多条出球小动脉 |
Li, J. J. X. |
PDF |
N/A |
Topologically distinct and equivalent multiple efferent arterioles in the human glomeruli |
| 山鸡椒叶甲醇粗提物在动物模型中对抗氧化应激、血栓形成、炎症及大便频率的影响 |
Arifuzzaman, S. |
PDF |
N/A |
Methanol Crude Extract of Litsea Monopetala Leaves combats oxidative stress, clot formation, inflammation and stool frequency in Animal Model |
| 慢性给予氟乙基诺美胺（FENM）在小鼠阿尔茨海默病模型中的神经保护作用 |
Carles, A. |
PDF |
N/A |
Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease |
| 转录组分析揭示了尼达尼布治疗在大鼠博来霉素模型中与脂质代谢和巨噬细胞参与相关的机制 |
Bonatti, M. |
PDF |
N/A |
Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model |
| 比较Ocimum gratissimum和Jatropha tanjorensis的抗氧化活性 2024。 |
Ike, E. C. |
PDF |
N/A |
Comparative antioxidant activity of Ocimum gratissimum and Jatropha tanjorensis 2024. |
| 计算机模拟靶向磷酸二酯酶5及阿赞那加果的催情效果体内评估 |
Ejiofor, I. I. |
PDF |
N/A |
In-silico Targeting Phosphodiesterase 5 and In-vivo Evaluation of the Aphrodisiac Effect of Azanza garckeana Fruit |
| 真菌毒素白色念珠菌素在肠道芯片模型中破坏上皮屏障完整性并引发炎症 |
Morelli, M. |
PDF |
N/A |
Mycotoxin candidalysin impairs epithelial barrier integrity and initiates inflammation in a gut-on-chip model |
| 发现和分离新型辣椒素及其与TRPV1相关活性 |
Smith, J. |
PDF |
N/A |
Discovery and isolation of novel capsaicinoids and their TRPV1-related activity |
| 环境相关铅暴露对SH-SY5Y细胞在整个神经元分化过程中的基因表达产生影响 |
Morgan, R. K. |
PDF |
N/A |
Environmentally Relevant Lead Exposure Impacts Gene Expression in SH-SY5Y Cells Throughout Neuronal Differentiation |
| REDD1是决定肾细胞癌对自噬抑制敏感性的一个因素，通过靶向PIM激酶活性可以实现治疗利用。 |
Carew, J. S. |
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N/A |
REDD1 is a determinant of the sensitivity of renal cell carcinoma cells to autophagy inhibition that can be therapeutically exploited by targeting PIM kinase activity |
| 经皮迷走神经刺激可减轻创伤后骨关节炎小鼠模型的疼痛和病情进展 |
Yadav, S. |
PDF |
N/A |
Transcutaneous Vagus Nerve Stimulation Reduces Pain and OA Progression in Mouse Models of Post-Traumatic Osteoarthritis |
| ATGL介导的脂解作用对肌细胞线粒体功能至关重要，并能增强PPARδ诱导的线粒体呼吸功能的改善。 |
Gemmink, A. |
PDF |
N/A |
ATGL-mediated lipolysis is essential for myocellular mitochondrial function and augments PPARδ-induced improvements in mitochondrial respiration |
| LPS与志贺毒素暴露对培养的人脐静脉内皮细胞RNA表达程序的协同作用。 |
Svilar, D. |
PDF |
N/A |
Synergy of LPS and Shiga-toxin exposure on the RNA expression program of cultured human umbilical vein endothelial cells. |
| 真空干燥的公羊精子在室温下保存四年后，其生育力得以保存。 |
Moncada, M. |
PDF |
N/A |
Fertility Preservation of Vacuum-Dried Ram Spermatozoa Stored for Four Years at Room Temperature |
| 番茄果实中碳代谢的组织特异性响应对低氧胁迫的反应 |
Li, X. |
PDF |
N/A |
Tissue-specific responses of the central carbon metabolism in tomato fruit to low oxygen stress |
| 在耐寒的蟋蟀Gryllus veletis中，HSP70在热应激后上调，但在冷冻应激后并未上调。 |
Adams, V. E. |
PDF |
N/A |
HSP70 is upregulated after heat but not freezing stress in the freeze-tolerant cricket Gryllus veletis |
| 蜜蜂对饮食中长期存在的酒精具有抵抗力。 |
Ostap-Chec, M. |
PDF |
N/A |
Honey bees are resilient to the long-term presence of alcohol in their diet |
| 豚鼠胎盘hIGF1纳米颗粒基因治疗以胎儿性别特异性的方式改善了胎儿生长受限相关的肝脏脂质和葡萄糖代谢相关信号通路的变化。 |
Davenport, B. N. |
PDF |
N/A |
Placental hIGF1 nanoparticle gene therapy in guinea pigs ameliorates fetal growth restriction-associated changes in hepatic lipid and glucose metabolism-related signaling pathways in a fetal sex-specific manner |
| 使用Nav1.5的N端片段进行基因治疗以治疗心脏通道病：一种增强心脏钠电流的新型反式互补机制 |
Gizon, M. |
PDF |
N/A |
Gene Therapy with the N-terminal Fragment of Nav1.5 for Cardiac Channelopathies: A Novel Transcomplementation Mechanism Potentiating the Cardiac Sodium Current |
| COSMOS：社区与单微生物优化系统 |
Raajaraam, L. |
PDF |
N/A |
COSMOS: COmmunity and Single Microbe Optimisation System |
| 通过同步给药方案来调控癌症免疫周期 |
Newton, P. K. |
PDF |
N/A |
Gaming the cancer-immunity cycle by synchronizing the dose schedules |
| MethylGPT：一种用于DNA甲基化组的基础模型 |
Ying, K. |
PDF |
N/A |
MethylGPT: a foundation model for the DNA methylome |
| 预测在MetaCyc知识库中注释的代谢物参与的代谢途径 |
Huckvale, E. D. |
PDF |
N/A |
Predicting the pathway involvement of metabolites annotated in the MetaCyc knowledgebase |
| C3-C3aR轴调节肺泡巨噬细胞的训练免疫 |
Earhart, A. P. |
PDF |
N/A |
The C3-C3aR axis modulates trained immunity in alveolar macrophages |
| 雷帕霉素增强CAR-T细胞在体内控制HIV复制和清除储藏库的作用。 |
Zhen, A. |
PDF |
N/A |
Rapamycin Enhances CAR-T Control of HIV Replication and Reservoir Elimination in vivo. |
| KDM6A介导的基因组不稳定性和代谢重编程的丧失，在膀胱癌中对免疫检查点治疗和化疗的反应存在差异性调控。 |
Singh, P. |
PDF |
N/A |
Loss of KDM6A-mediated genomic instability and metabolic reprogramming differentially regulates responses to immune checkpoint therapy and chemotherapy in bladder cancer. |
| 抗原流动性调节B细胞免疫突触中抗原捕获的动力学和精确性 |
McArthur, H. C. W. |
PDF |
N/A |
Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse |
| 综合应激反应促进巨噬细胞在自身免疫性糖尿病中的炎症和迁移 |
Wang, J. E. |
PDF |
N/A |
The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes |
| 儿童骨髓的单细胞多组学研究揭示了与基质细胞异质性相关的年龄依赖性谱系分化差异 |
Hanemaaijer, E. S. |
PDF |
N/A |
Single-cell multiomics of pediatric BM reveals age-dependent differences in lineage differentiation linked to stromal cell heterogeneity |
| 基底膜水凝胶抑制CAR-T细胞激活：纳米纤维素凝胶作为替代品以在三维细胞培养中保持T细胞功能。 |
Revilla, S. A. |
PDF |
N/A |
Basement membrane hydrogels dampen CAR-T cell activation: nanofibrillar cellulose gels as alternative to preserve T cell function in 3D cell cultures. |
| 利用血液单细胞转录组学整合内在和系统性免疫衰老 |
Tomusiak, A. |
PDF |
N/A |
Utilizing blood single-cell transcriptomics to integrate intrinsic and systemic immune aging |
| 弓形虫感染脑炎模型中不同CD8记忆T细胞亚群 |
Moretto, M. M. |
PDF |
N/A |
Divergent CD8 memory T cell subsets in an encephalitis model of Toxoplasma gondii infection |
| 揭示外分泌腺中由ILC2衍生的GM-CSF维持的独特巨噬细胞群体 |
Westermann, F. |
PDF |
N/A |
Unveiling a unique macrophage population in exocrine glands sustained by ILC2-derived GM-CSF |
| 脂肪来源基质细胞与人及大鼠胰岛共培养的分泌组分析揭示了具有增强再生能力的特征 |
Pinheiro-Machado, E. |
PDF |
N/A |
Secretome analysis of human and rat pancreatic islets co-cultured with adipose-derived stromal cells reveals a signature with enhanced regenerative capacities |
| TET2介导的表观遗传修饰促进2型糖尿病中胰腺β细胞的压力性衰老 |
Cai, W. |
PDF |
N/A |
TET2-mediated epigenetic modification promotes stress senescence of pancreatic β cells in type 2 diabetes mellitus |
| 通过培养条件调节脂肪来源基质细胞的分泌组：对血管生成、胶原沉积和免疫调节的影响。 |
Pinheiro-Machado, E. |
PDF |
N/A |
Modulating adipose-derived stromal cells' secretomes by culture conditions: effects on angiogenesis, collagen deposition, and immunomodulation. |
| 纤维化肝脏疾病中蛋白质毒性应激的蛋白质组学图谱 |
Rosenberger, F. A. |
PDF |
N/A |
The proteomic landscape of proteotoxic stress in a fibrogenic liver disease |
| 微管正端动力学与MOR1聚合酶的周转过程紧密耦合。 |
Eng, R. C. |
PDF |
N/A |
Microtubule plus-end dynamics are tightly coupled to the turnover of the MOR1 polymerase |
| 人类苦味受体在人类主动脉和冠状动脉内皮细胞中的表达谱 |
Kochany, P. |
PDF |
N/A |
Expression Profile of Human Bitter Taste Receptors in Human Aortic and Coronary Artery Endothelial Cells |
| 等渗介质处理可限制烧伤伤口微生物定植，并促进组织修复。 |
Horn, A. |
PDF |
N/A |
Isotonic medium treatment limits burn wound microbial colonization and improves tissue repair |
| 利用慢性胰腺炎患者来源的类器官模型鉴定分子和功能亚型 |
Osorio-Vasquez, V. |
PDF |
N/A |
Identification of molecular and functional subtypes using chronic pancreatitis patient-derived organoid models |
| 使用开源软件对全切片脂肪组织图像进行高通量脂肪细胞大小测量 |
Ramalho, A. C. |
PDF |
N/A |
High-throughput measurement of adipocyte size with open-source software using whole-slide adipose tissue images |
| BBS/CCT伴侣蛋白复合物确保粘附性G蛋白偶联受体ADGRV1定位于初级纤毛 |
Linnert, J. |
PDF |
N/A |
The BBS/CCT chaperonin complex ensures the localization of the adhesion G protein-coupled receptor ADGRV1 to primary cilia |
| 免疫抑制药物对内皮细胞功能表现出不同的影响。 |
Elezaby, A. |
PDF |
N/A |
Immunosuppression Drugs Exhibit Differential Effects on Endothelial Cell Function |
| H2S 重塑线粒体超微结构并破坏呼吸超级复合体 |
Hanna, D. A. |
PDF |
N/A |
H2S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes |
| 一项细胞生物学研究揭示了卵菌效应子运输机制的新见解 |
Tomczynska, I. |
PDF |
N/A |
A CELL BIOLOGY STUDY REVEALS NEW INSIGHTS INTO THE TRANSPORT MECHANISMS OF OOMYCETE EFFECTORS |
| 核糖核苷酸还原酶的细胞质定位对于基因组稳定性至关重要 |
Andreadis, C. |
PDF |
N/A |
Cytoplasmic localization of ribonucleotide reductase is essential for genome stability |
| 多组学揭示了伤口床微环境分泌信号对巨噬细胞的年龄依赖性代谢重编程 |
Forni, M. F. |
PDF |
N/A |
Multiomics reveals age-dependent metabolic reprogramming of macrophages by wound bed niche secreted signals |
| 增强人类诱导多能干细胞的冷冻保存：自下而上与传统冷冻几何形状 |
Teodoro, F. |
PDF |
N/A |
Enhancing cryopreservation of human iPSCs: Bottom-up vs Conventional freezing geometry |
| 景观复杂性的生态记忆塑造了淡水群落的多样性。 |
Tabi, A. |
PDF |
N/A |
The ecological memory of landscape complexity shapes diversity of freshwater communities |
| 量化猎物在避免鸟类捕食者攻击中，隐蔽、警戒和逃避策略的成功率 |
Linke, D. |
PDF |
N/A |
Quantifying the success of prey crypsis, aposematism and evasiveness in avoiding avian predators attack |
| 在鸟类属中，源振幅随着体重的增加而增加。 |
Ziegenhorn, M. A. |
PDF |
N/A |
Source amplitude increases with body mass across avian genera |
| 首次尝试使用性标记SSM4和ALLWSex2对长期保存的东北美短吻鲟（Acipenser brevirostrum）血液样本进行多重PCR验证。 |
Pozveh, H. S. T. |
PDF |
N/A |
First attempt to validate multiplex PCR with sex markers SSM4 and ALLWSex2 in long-term stored blood samples of eastern North American shortnose sturgeon (Acipenser brevirostrum). |
| 利用时空子采样建模美洲隼下降情况以提高eBird数据可靠性 |
Sharma, A. |
PDF |
N/A |
Modeling American Kestrel Decline Using Spatiotemporal Subsampling to Improve eBird Data Reliability |
| 环境DNA揭示了干旱地区临时水体中无脊椎动物群落的时间和空间变异性 |
Hedges, B. A. |
PDF |
N/A |
Environmental DNA reveals temporal and spatial variability of invertebrate communities in arid-lands ephemeral water bodies |
| 气候变化对物种生态位概念及分布的影响 |
Berti, E. |
PDF |
N/A |
The impacts of climate variability on the niche concept and distributions of species |
| 蜘蛛为理解节肢动物体型变异和性二型性的生态进化驱动因素提供了新的见解。 |
Ameline, C. |
PDF |
N/A |
Spiders bring new insight into the eco-evolutionary drivers of body size variation and sexual size dimorphism in arthropods |
| 全骨鱼类基因组揭示了脊椎动物免疫蛋白酶体的进化新奇性，这对MHCI功能具有重要意义。 |
Barker, A. V. |
PDF |
N/A |
Holostean genomes reveal evolutionary novelty in the vertebrate immunoproteasome that have implications for MHCI function |
| 综合分析CAM光合作用揭示其对丝兰初级代谢的影响 |
Wickell, D. A. |
PDF |
N/A |
Integrative analysis of CAM photosynthesis reveals its impact on primary metabolism in Yucca |
| 尤卡坦半岛咸水洞穴中海绵（多孔动物门，普通海绵纲）的物种多样性与线粒体DNA分析 |
Suarez-Moo, P. d. J. |
PDF |
N/A |
Species Diversity and Mitochondrial DNA Analysis of Sponges (Porifera, Demospongiae) in an Anchialine Cave on the Yucatan Peninsula |
| 在慈鲷鱼快速适应辐射过程中的环形物种形成平行案例 |
Gautier, G. |
PDF |
N/A |
Parallel cases of ring speciation within a rapid adaptive radiation of cichlid fishes |
| 基因表达和花粉表现表明，在具有不同交配系统的茄属物种之间，交配后选择发生了改变。 |
Biewer-Heisler, T. J. |
PDF |
N/A |
Gene expression and pollen performance indicate altered postmating selection between Solanum species with different mating systems |
| 欺骗者在合作持久性中的关键作用 |
Babajanyan, S. |
PDF |
N/A |
The key role of cheaters in the persistence of cooperation |
| 英国欧洲貂种群历史性人口下降的特征 |
Shaw, R. L. |
PDF |
N/A |
Characterisation of the historic demographic decline of the British European polecat population |
| 病毒和细胞蛋白质组结构域中内在无序性的演变 |
Mughal, F. |
PDF |
N/A |
Evolution of intrinsic disorder in the structural domains of viral and cellular proteomes |
| 适应性峰值的反应规范追踪可能解释化石记录中的时间序列 |
Ergon, R. |
PDF |
N/A |
Reaction norm tracking of fitness peaks may explain time series in the fossil record |
| 有害藻华形成性浮游藻类中的泛基因组生物学与进化 |
Sibbald, S. J. |
PDF |
N/A |
Pangenome biology and evolution in harmful algal-bloom-forming pelagophyte algae |
| 超越体型二态性：Rensch法则的过去、现在与未来 |
Toyama, K. S. |
PDF |
N/A |
Beyond size dimorphism: the past, present, and future of Rensch's Rule |
| 用于豹（Panthera pardus）非侵入性基因分型的SNP面板 |
Spong, G. |
PDF |
N/A |
SNP panel for non-invasive genotyping of leopard (Panthera pardus) |
| 同义密码子使用定义功能基因家族 |
Ghanegolmohammadi, F. |
PDF |
N/A |
Synonymous codon usage defines functional gene families |
| 辣椒（Capsicum annum L.）耐热性遗传多样性分析 |
Usmani, S. F. |
PDF |
N/A |
Genetic Diversity Analysis for Heat Stress Tolerance in Chili (Capsicum annum L.) |
| 研究R3HCC1L在胚胎发育和眼科疾病中可能的作用 |
Fischer, M. C. |
PDF |
N/A |
Investigating a possible role of R3HCC1L in embryonic development and ocular disease |
| 具有MYT1L杂合突变的小鼠寿命 |
Schreiber, A. |
PDF |
N/A |
Lifespan in rodents with MYT1L heterozygous mutation |
| JG2：日本人群特异性参考基因组的更新版本 |
Sriwichaiin, S. |
PDF |
N/A |
JG2: an updated version of the Japanese population-specific reference genome |
| StableLift：优化跨基因组构建的种系和体细胞变异检测 |
Wang, N. K. |
PDF |
N/A |
StableLift: Optimized Germline and Somatic Variant Detection Across Genome Builds |
| 表观遗传沉默和宿主基因组进化决定了病毒插入在棘阿米巴中的命运 |
Blais, C. |
PDF |
N/A |
Epigenetic silencing and host genome evolution determine fate of viral insertions in Acanthamoeba |
| 新兴的特比萘芬耐药性毛癣菌的基因组流行病学 |
Rhodes, J. |
PDF |
N/A |
Genomic epidemiology of emerging terbinafine-resistant Trichophyton indotineae |
| 一种用于造血祖细胞和干细胞靶向的模块化逐层纳米颗粒平台 |
Dacoba, T. G. |
PDF |
N/A |
A Modular Layer-by-Layer Nanoparticle Platform for Hematopoietic Progenitor and Stem Cell Targeting |
| 主肺动脉的构成性神经网络：发现未被发现的部分 |
Vervenne, T. |
PDF |
N/A |
Constitutive neural networks for main pulmonary arteries: Discovering the undiscovered |
| 使用氨基酸进行蛋白质分类的混合Transformer与神经网络配置 |
Labiosa, N. |
PDF |
N/A |
Hybrid Transformer and Neural NetworkConfiguration for Protein Classification UsingAmino Acids |
| 低压等容冷冻作为一种可扩展技术用于新鲜食品保存 |
Maida, A. |
PDF |
N/A |
Low-pressure Isochoric Freezing as a scalable technique for fresh food preservation |
| 重构mRNA脂质纳米颗粒以实现向胰腺的全身递送 |
Isaac, I. |
PDF |
N/A |
Reengineering mRNA lipid nanoparticles for systemic delivery to pancreas |
| 体外骨骼肌构建物的三维生物打印用生物墨水的开发与表征 |
Kado Abdalkader, R. |
PDF |
N/A |
Development and characterization of bioinks for 3D bioprinting of in vitro skeletal muscle constructs |
| 基于低RT的鼠肝细胞基因组编辑保真性：挑战与解决方案 |
Dunyak, M. T. |
PDF |
N/A |
Low RT-based Genome Editing Fidelity in Mouse Hepatocytes: Challenges and Solutions |
| 通过非内体途径向免疫细胞体外递送mRNA，无需进行核苷修饰。 |
Ghoshal, B. |
PDF |
N/A |
Ex Vivo Delivery of mRNA to Immune Cells Via a Non-Endosomal Route Obviates the Need for Nucleoside Modification |
| 免疫学比较：改良小鼠子宫内纤维化模型中菌株与诱导方法的差异 |
Hernandez, J. L. |
PDF |
N/A |
Immunologic comparisons of strain and induction method in an improved mouse model of intrauterine fibrosis |
| 在无意中不当处理婴儿时的高重力加速度：对婴儿摇晃综合征诊断的影响 |
Lee-Confer, J. S. |
PDF |
N/A |
High G-Forces in Unintentionally Improper Infant Handling: Implications for Shaken Baby Syndrome Diagnosis |
| 基于肌肉的生物混合装置用低成本打印机的可打印树脂的细胞毒性和特性 |
Liao, A. S. |
PDF |
N/A |
Cytotoxicity and Characterization of 3D-Printable Resins Using a Low-Cost Printer for Muscle-based Biohybrid Devices |
| 利用水和其自由基进行碰撞诱导和氧附着解离的双重碎裂，实现C=C位点解析的脂质组学 |
Takeda, H. |
PDF |
N/A |
Dual fragmentation via collision-induced and oxygen attachment dissociations using water and its radicals for C=C position-resolved lipidomics |
| 一种快速、肌肉驱动的生物混合游泳机器人 |
Drennan, W. C. |
PDF |
N/A |
A fast, muscle-actuated biohybrid swimming robot |
| 神经肌肉骨骼建模流程：基于MATLAB的OpenSim模型个性化与治疗优化功能 |
Hammond, C. V. |
PDF |
N/A |
The Neuromusculoskeletal Modeling Pipeline: MATLAB-based Model Personalization and Treatment Optimization Functionality for OpenSim |
| 基因表达的多重超声成像 |
Nystrom, N. N. |
PDF |
N/A |
Multiplexed ultrasound imaging of gene expression |
| 使用基于贝叶斯优化的迭代实验设计加速细胞培养基开发 |
Narayanan, H. |
PDF |
N/A |
Accelerating Cell Culture Media Development Using Bayesian Optimization-Based Iterative Experimental Design |
| RCANE：一种利用RNA-seq数据进行全基因组泛癌种体细胞拷贝数变异预测的深度学习算法 |
Ge, C. |
PDF |
N/A |
RCANE: A Deep Learning Algorithm for Whole-genome Pan-Cancer Somatic Copy Number Aberration Prediction using RNA-seq Data |
| DSA-DeepFM：一种用于预测抗癌协同药物组合的双阶段注意力增强DeepFM模型 |
Gu, Y. |
PDF |
N/A |
DSA-DeepFM: A Dual-Stage Attention-Enhanced DeepFM Model for Predicting Anticancer Synergistic Drug Combinations |
| AnnSQL：一个基于Python SQL的包，用于在笔记本电脑上进行大规模单细胞基因组学分析 |
Pavan, K. |
PDF |
N/A |
AnnSQL: A Python SQL-based package for large-scale single-cell genomics analysis on a laptop |
| Limelight - 一个开源的基于网络的工具，用于可视化、分享和分析来自DDA管道的质谱数据 |
Riffle, M. |
PDF |
N/A |
Limelight - An open, web-based tool for visualizing, sharing, and analyzing mass spectrometry data from DDA pipelines |
| Squeakuences：一个便携工具，用于格式化干净无瑕的序列，以消除生物信息学软件的不兼容性 |
Forsythe, E. S. S. |
PDF |
N/A |
Squeakuences: a portable tool for formatting squeaky-clean sequences to eliminate bioinformatic software incompatibilities |
| CytoSpatio：利用多范围、多类型点过程模型学习细胞类型的空间关系 |
Chen, H. |
PDF |
N/A |
CytoSpatio: Learning cell type spatial relationships using multirange, multitype point process models |
| AlloPool：一种用于蛋白质系统中动态变构网络预测的自适应图神经网络 |
Barth, P. |
PDF |
N/A |
AlloPool: An Adaptive Graph Neural Network for Dynamic Allosteric Network Prediction in Protein Systems |
| KOnezumi-AID：一种利用Target-AID自动化设计多重基因敲除的软件 |
Taki, T. |
PDF |
N/A |
KOnezumi-AID: A Software to Automate the Design of Multiplex Knockouts Using Target-AID |
| SpaMTP：空间代谢组学和转录组学数据的整合统计分析与可视化。 |
Causer, A. |
PDF |
N/A |
SpaMTP: Integrative Statistical Analysis and Visualisation of Spatial Metabolomics and Transcriptomics data. |
| 使用残差神经网络对基因区域中可变剪接事件的差异分析 |
Ciccolella, S. |
PDF |
N/A |
Differential Analysis of Alternative Splicing Events in gene regions using Residual Neural Networks |
| DiCARN-DNase: 利用扩张级联ResNet结合自注意力和DNase-seq染色质可及性数据提升细胞间Hi-C分辨率 |
Olowofila, S. A. |
PDF |
N/A |
DiCARN-DNase: Enhancing Cell-to-Cell Hi-C Resolution Using Dilated Cascading ResNet with Self-Attention and DNase-seq Chromatin Accessibility Data |
| 克服公共数据库中脊椎动物硒蛋白基因注释的普遍缺陷 |
Tico, M. |
PDF |
N/A |
Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases |
| 利用空间蛋白质组学和少样本学习对原发组织进行高精度预测，以推断5年无进展黑色素瘤生存率 |
Moeller, A. |
PDF |
N/A |
High-accuracy prediction of 5-year progression-free melanoma survival using spatial proteomics and few-shot learning on primary tissue |
| 使用TemSOMap将单细胞RNA测序的谱系解析数据与空间转录组学数据进行映射 |
Pan, X. |
PDF |
N/A |
Mapping lineage-resolved scRNA-seq data with spatialtranscriptomics using TemSOMap |
| 量化荧光标记蛋白的核定位 |
Hurbain, J. |
PDF |
N/A |
Quantifying the nuclear localisation of fluorescently tagged proteins |
| scRNA-seq与网络传播的联合应用突显了泛癌肿瘤浸润T细胞的关键特征 |
MANGELINCK, A. |
PDF |
N/A |
The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells |
| 检测海洋共生体中的特殊基因：一种系统发育偏差方法识别出增强重组的变体 |
Zhou, X. |
PDF |
N/A |
Detecting Special Genes in Marine Symbionts: A Phylogeny-Deviation Approach Identifies Recombination-Enhancing Variants |
| CIWARS：一种基于纵向宏基因组数据的水传播抗生素抗性监测网络服务器 |
Emon, M. I. |
PDF |
N/A |
CIWARS: a web server for waterborne antibiotic resistance surveillance using longitudinal metagenomic data |
| BTS：可扩展的贝叶斯组织评分，用于在多组学数据中优先考虑GWAS变异及其功能背景 |
Kuksa, P. P. |
PDF |
N/A |
BTS: scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across omics data |
| AutoPM3：通过LLM驱动的PM3证据提取增强变体解读 |
Li, S. |
PDF |
N/A |
AutoPM3: Enhancing Variant Interpretation via LLM-driven PM3 Evidence Extraction from Scientific Literature |
| PEI促进高效基因递送至细胞的分子参数解析 |
Montano Gonzalez, P. A. |
PDF |
N/A |
Insight Into the Molecular Parameters of PEI Promoting an Efficient Gene Delivery into Cells |
| 溶酶体阳离子通道TMEM175的选择性通透性与门控机制 |
Schulze, T. |
PDF |
N/A |
Proton selective conductance and gating of lysosomal cation channel TMEM175 |
| 临床相关伯克霍尔德菌属产β-内酰胺酶的动态差异 |
Gu, J. |
PDF |
N/A |
Dynamic Differences in Clinically relevant Pen β-Lactamases from Burkholderia spp. |
| 探索恶性疟原虫二氢叶酸还原酶的适应性景观：抗叶酸耐药性的进化见解 |
Muzata, D. |
PDF |
N/A |
Navigating the Fitness Landscapes of Plasmodium falciparum Dihydrofolate Reductase: Evolutionary Insights into Antifolate Resistance |
| 异质性诱导的受限嵌段共聚物分相 |
Mohanta, D. |
PDF |
N/A |
Heterogeneity induced Block Copolymer Segregation in Confinement |
| 基于密度的无偏、可重复聚类优化应用于单分子定位显微镜 |
Hammer, J. L. |
PDF |
N/A |
Density-based optimization for unbiased, reproducible clustering applied to single molecule localization microscopy |
| 用于指导低温聚焦离子束铣削超越轴向衍射极限的光学干涉 |
Sica, A. V. |
PDF |
N/A |
Optical Interference for the Guidance of Cryogenic Focused Ion Beam Milling Beyond the Axial Diffraction Limit |
| 研究绿色方法合成铜纳米颗粒与电离辐射对乳酸脱氢酶（LDH）的影响 |
Sih, B. T. |
PDF |
N/A |
Study the Effect of Green Method Synthesis of Copper Nanoparticles with Ionization Radiation on Lactate Dehydrogenase (LDH) |
| 无模型光子分析扩散型单分子FRET实验 |
Terterov, I. |
PDF |
N/A |
Model-free photon analysis of diffusion-based single-molecule FRET experiments |
| Kauffman模型中闭合与开放式进化之间因果关系的证据 |
Faggian, M. F. |
PDF |
N/A |
Evidence of causality between Closure and Open-Ended Evolution in the Kauffman model |
| 内在的生物能量适应性变化补偿了HER2驱动的乳腺肿瘤中线粒体含量的减少。 |
Frangos, S. M. |
PDF |
N/A |
Intrinsic bioenergetic adaptations compensate for reduced mitochondrial content in HER2-driven mammary tumors |
| 自噬与外泌体途径的相互调控通过GABARAPL2和Alix介导，以促进细胞稳态 |
soni, N. |
PDF |
N/A |
Reciprocal regulation of autophagy and exosome pathway is mediated by GABARAPL2 and Alix to facilitate cellular homeostasis |
| 雄激素受体相互作用揭示了内分泌抵抗性乳腺癌中类固醇介导的代谢转变。 |
Bleach, R. |
PDF |
N/A |
Androgen receptor interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer. |
| TET1通过表观遗传重塑和免疫调节在肺腺癌中发挥肿瘤抑制作用 |
Rahim, A. |
PDF |
N/A |
TET1 Functions as a Tumor Suppressor in Lung Adenocarcinoma Through Epigenetic Remodeling and Immune Modulation |
| 在胶质母细胞瘤中进行原位单细胞空间分析，评估基质基因表达 |
De, A. |
PDF |
N/A |
In Situ Single-Cell Spatial Profiling of Matrisome Gene Expression in Glioblastoma |
| ADAT2/3介导的tRNA编辑促进癌细胞生长和肿瘤发生 |
Ramirez-Moya, J. |
PDF |
N/A |
ADAT2/3-mediated tRNA editing promotes cancer cell growth and tumorigenicity |
| XPO1抑制通过调节Wnt/β-连环蛋白信号通路来减少结直肠癌的肿瘤发生。 |
Evans, A. E. |
PDF |
N/A |
XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis. |
| 胰腺神经内分泌肿瘤综合RNA剪接图谱揭示了新的临床分子关联 |
Blazquez-Encinas, R. |
PDF |
N/A |
An integrative RNA spliceosomic landscape of pancreatic neuroendocrine tumors unveils novel clinicomolecular associations |
| 可遗传的细胞状态塑造了癌细胞中的药物持久性相关性和种群动态 |
Iyer, A. |
PDF |
N/A |
Inheritable cell-states shape drug-persister correlations and population dynamics in cancer cells |
| 使用化学合成约束双环肽条件性激活NK细胞功能，针对NKp46和肿瘤表达的抗原 |
Dufort, F. J. |
PDF |
N/A |
Conditional activation of NK cell function using chemically synthetic constrained bicyclic peptides directed against NKp46 and tumor-expressed antigens |
| 利用公民科学方法进行以研究为导向的进化论和古生物学教学 |
Lautenschlager, S. |
PDF |
N/A |
Using a citizen science approach for research-informed teaching of evolution and palaeontology |
| Nef在南非女性中复制能力强的HIV库长期维持中的作用 |
Ismail, S. D. |
PDF |
N/A |
The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women |
| 脂肪酸介导的HepaRG细胞中CYP2E1活性的诱导并不系统性地与对乙酰氨基酚的细胞毒性加剧相关。 |
Penhoat, C. |
PDF |
N/A |
Fatty acid-mediated induction of CYP2E1 activity in HepaRG cells is not systematically associated with exacerbated acetaminophen cytotoxicity |
| 黄嘌呤氧化还原酶的亚硝酸盐还原酶活性维持心血管健康 |
Dyson, N. |
PDF |
N/A |
The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health |
| 来自患有肠病的孟加拉国发育迟缓儿童的小肠细菌的代际传递的影响 |
Pruss, K. M. |
PDF |
N/A |
Effects of intergenerational transmission of small intestinal bacteria cultured from stunted Bangladeshi children with enteropathy |
| 昆虫识别软件AInsectID版本1.1：基于深度卷积神经网络迁移学习的昆虫物种识别软件 |
Sadia, H. |
PDF |
N/A |
AInsectID Version 1.1: an Insect Species Identification Software Based on the Transfer Learning of Deep Convolutional Neural Networks |
| 言论自由在全球范围内预示着动物福利保护 |
Montalcini, C. M. |
PDF |
N/A |
Freedom of speech predicts animal welfare protection across the globe |
| ImmunoStruct：整合蛋白质序列、结构和生化特性以进行免疫原性预测与解释 |
Givechian, K. B. |
PDF |
N/A |
ImmunoStruct: Integration of protein sequence, structure, and biochemical properties for immunogenicity prediction and interpretation |
| 未锚定的泛素链通过UBXN1促进非经典炎症小体 |
Yang, D. |
PDF |
N/A |
Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1 |
| 一种新颖的开源培养系统助力建立了首个涉及巨型纤毛虫Zoothamnium niveum的全周期化学合成共生模型系统。 |
Contarini, P.-E. |
PDF |
N/A |
A novel open-source cultivation system helps establish the first full cycle chemosynthetic symbiosis model system involving the giant ciliate Zoothamnium niveum |
| 材料性质与细胞效应之间的相互作用驱动了氧化石墨烯与癌细胞和非癌细胞之间不同的相互作用模式。 |
Chen, Y. |
PDF |
N/A |
Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells |
| 转录因子聚类的特异性在基因组中被编码 |
Dongre, S. |
PDF |
N/A |
Specificity in transcription factor clustering is encoded in the genome |
| 父母谈判策略演变中替代后代抚养模式的涌现 |
Zheng, J. |
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N/A |
Emergence of alternative offspring care patterns from the evolution of parental negotiation strategies |
| 松鼠：从四叶网络或序列比对中重建半有向的系统发育一级网络 |
Holtgrefe, N. |
PDF |
N/A |
Squirrel: Reconstructing semi-directed phylogenetic level-1 networks from four-leaved networks or sequence alignments |
| 城市和农村白三叶草种群中选择性清除的特征 |
Santangelo, J. |
PDF |
N/A |
Signatures of selective sweeps in urban and rural white clover populations |
| 双相适应性进化抗菌药物耐药性 |
Das, S. G. |
PDF |
N/A |
Biphasic adaptive evolution of antimicrobial resistance |
| 在溯祖分化模型中分支大小的分布 |
Song, Y. |
PDF |
N/A |
The distribution of clade size in a coalescent diversification model |
| 跨拓扑关联域（TAD）边界的旁观者激活支持了一种依赖于凝聚蛋白的增强子功能枢纽模型 |
Williamson, W. I. |
PDF |
N/A |
Bystander activation across a TAD boundary supports a cohesin-dependent hub-model for enhancer function |
| 体内单细胞核糖体分析揭示了衰老过程中细胞类型特异性翻译程序 |
Dure, C. |
PDF |
N/A |
In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging |
| 创伤应激暴露后，随着时间和组织的变化，转录水平的改变为我们提供了分子层面的见解，揭示了治疗机会窗口的存在。 |
McKibben, L. A. |
PDF |
N/A |
Transcriptional changes across tissue and time provide molecular insights into a therapeutic window of opportunity following traumatic stress exposure |
| 通过FUNCODE量化人类和小鼠调控元件的功能保守性 |
Fang, W. |
PDF |
N/A |
Quantifying Functional Conservation of Human and Mouse Regulatory Elements via FUNCODE |
| 来自受污染宿主的Kudoa基因组显示出广泛的基因组顺序保守性和快速的序列进化。 |
Weber, C. C. |
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N/A |
Kudoa genomes from contaminated hosts reveal extensive gene order conservation and rapid sequence evolution |
| 人类皮下脂肪组织的单细胞DNA甲基组和三维基因组图谱 |
Chen, Z. J. |
PDF |
N/A |
Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue |
| 高通量制备胶原微球用于三维细胞培养及胞外囊泡生产 |
Ali, S. |
PDF |
N/A |
High-throughput Generation of Collagen Microbeads for 3D Cell Culture and Extracellular Vesicle Production |
| 基于Transformer的生存结果预测方法 |
Mellors, T. |
PDF |
N/A |
A Transformer-Based Approach to Survival Outcome Prediction |
| 基于组织学的微卫星不稳定性与免疫治疗反应预测的深度高斯过程及不确定性估计 |
Park, S. |
PDF |
N/A |
Deep Gaussian Process with Uncertainty Estimation for Microsatellite Instability and Immunotherapy Response Prediction Based on Histology |
| 评估从单细胞RNA测序数据中构建T细胞受体的方法 |
Tian, R. |
PDF |
N/A |
Evaluation of T Cell Receptor Construction Methods from scRNA-Seq Data |
| GenoSiS：一种用于创建动态患者匹配队列的生物库规模基因型相似性搜索架构 |
Schneider, K. |
PDF |
N/A |
GenoSiS: A Biobank-Scale Genotype Similarity Search Architecture for Creating Dynamic Patient-Match Cohorts |
| 揭开睡眠之谜：探索新近描述的洛基城堡附近洛基古菌门中的系统发生基因组睡眠信号 |
Pandi-Perumal, S. R. |
PDF |
N/A |
Unraveling the Mysteries of Sleep: Exploring Phylogenomic Sleep Signals in the Recently Characterized Archaeal Phylum Lokiarchaeota near Loki's Castle |
| 利用主题建模探索转录组数据的潜在空间 |
Valle, F. |
PDF |
N/A |
Exploring the latent space of transcriptomic data withtopic modeling |
| 疾病相关突变会扰乱神经凝聚物的物理性质、组成和RNA翻译。 |
Ahangama Liyanage, L. |
PDF |
N/A |
Disease-linked mutations dysregulate neuronal condensate physical properties, composition, and RNA translation |
| 修订的扩散定律允许对膜组织的纳米尺度进行定量表征 |
Svobodova, B. |
PDF |
N/A |
Revised diffusion law permits quantitative nanoscale characterization of membrane organization |
| GPCR-G蛋白预偶联与激活的结构基础：从CCR1-Gi复合物中获得的见解 |
Shao, Z. |
PDF |
N/A |
Structural Basis of GPCR-G Protein Pre-coupling and Activation: Insights from CCR1-Gi Complex |
| 局部离子条件调节α-突触核蛋白的聚集倾向，并影响其结构多态性。 |
Zacharopoulou, M. |
PDF |
N/A |
Local ionic conditions modulate the aggregation propensity and influence the structural polymorphism of alpha-synuclein |
| 一种新的99mTc-PSMA-HBED-CC标记方法 |
Phromphao, B. |
PDF |
N/A |
A New Labelling Method of 99mTc-PSMA-HBED-CC |
| β-羟基丁酸代谢的另一途径支持癌细胞中的脂肪酸合成 |
Kaluba, F. C. |
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N/A |
An alternative route for β-hydroxybutyrate metabolism supports fatty acid synthesis in cancer cells |
| 每个癌症细胞的转录组中都编码了患者肿瘤中一种独特的恶性细胞类型。 |
Saurty-Seerunghen, M. S. |
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N/A |
A unique malignant cell type per patient tumor is encoded in each cancer cell transcriptome. |
| 白血病对健康的造血干细胞和祖细胞具有持久的印记。 |
Chen, D.-W. |
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N/A |
Leukemia confers a durable imprint on healthy hematopoietic stem and progenitor cells |
| 利用斑鸠菊叶提取物进行生物银纳米颗粒的植物辅助合成：表征、抗菌、抗炎及急性毒性概况 |
Nyuyfoni, G. F. |
PDF |
N/A |
Phytoassisted synthesis of biogenic silver nanoparticles using Vernonia amygdalina leaf extract: characterization, antibacterial, anti-inflammatory, and acute toxicity profile |
| ABRpresto：一种利用子平均间的重采样互相关进行听觉脑干反应自动阈值设定的算法 |
Shaheen, L. A. |
PDF |
N/A |
ABRpresto: An algorithm for automatic thresholding of the Auditory Brainstem Response using resampled cross-correlation across subaverages |
| PGR5对于叶绿体和蓝细菌中依赖氧化还原的ATP合酶调控是必需的。 |
Nikkanen, L. |
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N/A |
PGR5 is needed for redox-dependent regulation of ATP synthase both in chloroplasts and in cyanobacteria |
| 结构变异有助于水稻的遗传多样性和杂种优势 |
Dan, Z. |
PDF |
N/A |
Structural variations contribute to genetic diversity and heterosis in rice |
| 线粒体效率决定酵母中的克鲁勃效应 |
Battjes, J. |
PDF |
N/A |
Mitochondrial efficiency determines Crabtree effect across yeasts |
| 突触和体细胞靶向的ArcLight，一种遗传编码的电压指示器 |
Zhong, S. |
PDF |
N/A |
Synaptic and Somatic Targeting of ArcLight, a Genetically Encoded Voltage Indicator |
| 非免疫人血清中的C1q对临床结核分枝杆菌复合体菌株具有非冗余的补体功能。 |
Duque, M. A. |
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N/A |
C1q in non-immune human serum has a non-redundant complement function towards clinical Mycobacterium tuberculosis complex strains |
| 成骨细胞和骨肉瘤中大规模染色体构象的差异调控 |
Bisht, M. |
PDF |
N/A |
Differential Regulation of Large-scale Chromosome Conformations in Osteoblasts and Osteosarcoma |
| AURKA通过磷酸化HEC1来控制卵母细胞纺锤体组装检验点和染色体对齐。 |
Blengini, C. S. |
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N/A |
AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation |
| SUV39H1介导的KLF4和KDM4A调控协同调节平滑肌细胞表型可塑性 |
Chatterjee, P. |
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N/A |
SUV39H1 mediated regulation of KLF4 and KDM4A coordinate smooth muscle cell phenotypic plasticity |
| 来自软骨中间带的CILP通过Keap1-Nrf2轴抑制早期骨关节炎运动疗法中的透明软骨纤维化和软骨细胞铁死亡 |
Jia, S. |
PDF |
N/A |
CILP from Cartilage Intermediate Zone Inhibits Hyaline Cartilage Fibrosis and Chondrocyte Ferroptosis via Keap1-Nrf2 Axis in Early Osteoarthritis Exercise Therapy |
| 使用染色质纤维分析和R-ODD-BLOBS程序建模DNA复制叉的稳定性和崩溃 |
Cheng, K. |
PDF |
N/A |
Modelling DNA replication fork stability and collapse using chromatin fiber analysis and the R-ODD-BLOBS program |
| 与选择性伐木和森林再生相关的系统发育和功能组成变化在刚果盆地的热带雨林中 |
Depecker, J. |
PDF |
N/A |
Phylogenetic and functional compositional shifts associated with selective logging and forest regrowth in tropical rainforests of the Congo Basin |
| 岛屿人口统计学：哥特兰岛标志性金雕的繁殖动态及驱动因素 |
Singh, N. J. |
PDF |
N/A |
Island population demography: Breeding dynamics and drivers of Gotland's iconic Golden Eagles |
| 利用代谢生物标志物绘制病毒分流在广泛分布的颗石藻藻华中的分布图 |
Kuhlisch, C. |
PDF |
N/A |
Mapping of the viral shunt across widespread coccolithophore blooms using metabolic biomarkers |
| 环境DNA和野生动物相机陷阱揭示了淡水花岗岩岩池中互补的脊椎动物访问模式 |
Hedges, B. A. |
PDF |
N/A |
Environmental DNA and wildlife camera traps uncover complimentary vertebrate visitation patterns at freshwater granite rock-holes |
| 合成基因驱动在种群抑制中的自然选择可以倾向于驱动的中等强度。 |
Beaghton, P. J. |
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N/A |
Natural selection of synthetic gene drives for population suppression can favour an intermediate strength of drive |
| 周期基因改变了亚洲玉米螟的昼夜和季节性时间调控 |
Dayton, J. N. |
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N/A |
The period gene alters daily and seasonal timing in Ostrinia nubilalis |
| 社会家庭结构和生物地理学促进了唯一一种真社会性甲虫——Austroplatypus incompertus（象甲科：Platypodinae亚科）的基因组分化和隐秘物种形成。 |
Bickerstaff, J. |
PDF |
N/A |
Social family structure and biogeography contribute to genomic divergence and cryptic speciation in the only eusocial beetle species, Austroplatypus incompertus (Curculionidae: Platypodinae) |
| atad3-null斑马鱼胚胎的转录组分析揭示了可能的疾病机制 |
Ezer, S. |
PDF |
N/A |
Transcriptome analysis of atad3-null zebrafish embryos elucidates possible disease mechanisms |
| 多基因评分-罕见变异因果枢轴：复杂疾病遗传学发现的条件性方法 |
Shaw, C. A. |
PDF |
N/A |
The Polygenic Score - Rare Variant Causal Pivot: A Conditional Approach to Discovery in Complex Disease Genetics |
| 一个用于CADD评分生成的通用流程：鸡CADD和火鸡CADD |
Lensing, K. |
PDF |
N/A |
A generic pipeline for CADD score generation: chickenCADD and turkeyCADD |
| 探索基于微孔的单细胞RNA测序方法（HIVE），用于简化马支气管肺泡灌洗细胞的处理 |
Fegraeus, K. |
PDF |
N/A |
Exploring a pico-well based scRNA-seq method (HIVE) for simplified processing of equine bronchoalveolar lavage cells |
| 一种全基因组编码，用于定义细胞类型特异的CTCF结合和染色质组织 |
Do, C. |
PDF |
N/A |
A genome wide code to define cell-type specific CTCF binding and chromatin organization |
| 无标记鸟枪法蛋白质组学中监测宿主细胞蛋白质的MS/MS搜索算法比较分析，使用捕获离子迁移和ddaPASEF技术 |
Plisnier, M. |
PDF |
N/A |
Comparative analysis of MS/MS search algorithms in label-free shotgun proteomics for monitoring host-cell proteins using trapped ion mobility and ddaPASEF |
| 修饰肽、可编程的DNA四面体用于调节生物系统中的自噬 |
Naveena, H. A. |
PDF |
N/A |
Peptide modified, programmable DNA tetrahedra to modulate autophagy in biological systems |
| 利用声学报告基因进行基于细胞的非侵入性成像 |
Shivaei, S. |
PDF |
N/A |
Non-invasive imaging of cell-based therapies using acoustic reporter genes |
| qByte：开源等温荧光计，旨在普及核酸、蛋白质和细胞的分析 |
Lombardero, F. J. Q. |
PDF |
N/A |
qByte: Open-source isothermal fluorimeter for democratizing analysis of nucleic acids, proteins and cells |
| 长期大变形过程中三维多细胞动力学引起的应变软化和滞后现象 |
Tsubota, K.-i. |
PDF |
N/A |
Strain softening and hysteresis arising from 3D multicellular dynamics during long-term large deformation |
| 脉冲场消融过程中热侧效应的定量分析 |
Mercado Montoya, M. |
PDF |
N/A |
Quantification of thermal side effects during pulsed field ablation |
| 利用语言引导的视觉模型进行空间蛋白质组学的广义细胞表型分析 |
Wang, X. |
PDF |
N/A |
Generalized cell phenotyping for spatial proteomics with language-informed vision models |
| 数据驱动的基因表达特征富集分析优化 |
Wenzel, A. T. |
PDF |
N/A |
Data driven refinement of gene expression signatures for enrichment analysis |
| 通过Visium、GeoMx DSP和Chromium方法对存档肿瘤组织进行转录组分析，揭示了患者间和患者内的异质性 |
Dong, Y. |
PDF |
N/A |
Transcriptome Analysis of Archived Tumor Tissues by Visium, GeoMx DSP, and Chromium Methods Reveals Inter- and Intra-Patient Heterogeneity |
| 通过种子线性规划与逆折叠和蛋白质语言模型进行抗体库设计 |
Hayes, C. F. |
PDF |
N/A |
Antibody Library Design by Seeding LinearProgramming with Inverse Folding and ProteinLanguage Models |
| 使用深度学习方法进行蛋白质复合物物理感知模型精度估计 |
Wang, H. |
PDF |
N/A |
Physical-aware model accuracy estimation for protein complex using deep learning method |
| Smile-to-Bert：一种为物理化学性质预测和SMILES嵌入生成而训练的BERT架构 |
Barranco-Altirriba, M. |
PDF |
N/A |
Smile-to-Bert: A BERT architecture trained for physicochemical properties prediction and SMILES embeddings generation |
| 利用预训练视觉变换器和大型语言模型进行癫痫发作预测 |
Parani, P. |
PDF |
N/A |
Utilizing Pretrained Vision Transformers and LargeLanguage Models for Epileptic Seizure Prediction |
| 基于单基因的AI模型通过整合全基因组CRISPR和组学数据的生物学解释，识别核心及特定环境下的必需基因 |
Chou, C.-Y. |
PDF |
N/A |
A single-gene-based AI model to identify core and context-specific essential genes by biological interpretation from pooled genome-wide CRISPR and omics data |
| DGRNA：一种具有双向注意力机制的长上下文RNA基础模型 Mamba2 |
Yuan, Y. |
PDF |
N/A |
DGRNA: a long-context RNA foundation model with bidirectional attention Mamba2 |
| 在非结构化环境中导航：评估AlphaFold在预测蛋白质中缺失残基和结构无序方面的有效性 |
Zheng, S. |
PDF |
N/A |
Navigating the Unstructured by Evaluating AlphaFold's Efficacy in Predicting Missing Residues and Structural Disorder in Proteins |
| FIBOS：用于分析蛋白质包装和结构的R和Python包 |
Soares, H. H. M. |
PDF |
N/A |
FIBOS: R and Python packages for analyzing protein packing and structure |
| 细菌种群聚集模型中非指数反转时间的角色 |
Batista, M. |
PDF |
N/A |
Role of Non-Exponential Reversal times in Aggregation Models of Bacterial Populations |
| 评估阿尔茨海默病中淀粉样β和Tau寡聚体的联合神经毒性：一项新标准 |
Kuznetsov, A. V. |
PDF |
N/A |
Evaluating Combined Neurotoxicity of Amyloid Beta and Tau Oligomers in Alzheimer's Disease: A New Criterion |
| 上采样点扩散函数（PSF）实现了高精度的三维超分辨率成像，同时保持了稀疏的采样率。 |
Chen, J. |
PDF |
N/A |
Up sampled PSF enables high accuracy 3D super-resolution imaging with sparse sampling rate |
| 抑制H3K27M增强的ATM信号通路可提高弥漫中线胶质瘤的放疗效果 |
Peterson, E. R. |
PDF |
N/A |
Inhibition of H3K27M-enhanced ATM signaling increases radiation efficacy in diffuse midline glioma |
| HIRA-SETDB1-H3K9me3轴调控慢性髓系白血病细胞的染色质结构 |
Shirude, M. B. |
PDF |
N/A |
HIRA-SETDB1-H3K9me3 axis regulate chromatin architecture in chronic myeloid leukemia cells |
| IKAROS促进B细胞急性淋巴母细胞白血病在面对CD19和CD22靶向治疗时的抗原逃逸。 |
Domizi, P. |
PDF |
N/A |
IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell acute lymphoblastic leukemia |
| CT诊断颞下颌关节骨关节炎的准确性相对于组织病理学发现——一项针对41匹马的离体研究 |
Jasinski, T. |
PDF |
N/A |
Accuracy of computed tomography in diagnosing temporomandibular joint osteoarthritis relative to histopathological findings - an ex-vivo study of 41 horses |
| 针对CD38阳性血液系统恶性肿瘤的靶向阿尔法疗法：Ac-巨噬细胞-伊沙妥昔单抗 |
Herrero Alvarez, N. |
PDF |
N/A |
Targeted Alpha Therapy with Ac-Macropa-Isatuximab for CD38-positive Hematological Malignancies |
| 缺氧暴露微调海龟细胞的线粒体功能 |
Arango, B. G. |
PDF |
N/A |
Hypoxia exposure fine-tunes mitochondrial function in sea turtle cells |
| 着丝粒重复多样性导致啤酒花（Humulus lupulus）中非孟德尔分离模式 |
Horakova, L. |
PDF |
N/A |
Centromeric repeat diversity underlies non-Mendelian segregation pattern in hop (Humulus lupulus) |
| 通过信号输入和细胞间通讯调节胰腺β细胞的钙动力学 |
Shang, X. |
PDF |
N/A |
Tunability of calcium dynamics by signaling inputs and cell-cell communication in pancreatic beta cells |
| 跨多个数据集的复杂动作停止探索：对动作取消和重新编程机制的洞察 |
Salomoni, S. E. |
PDF |
N/A |
An exploration of complex action stopping across multiple datasets: Insights into the mechanisms of action cancellation and re-programming |
| 表达速激肽1的丘脑下核旁亚核神经元控制主动回避学习 |
Hu, R. |
PDF |
N/A |
Tachykinin1-expressing neurons in the parasubthalamic nucleus control active avoidance learning |
| 放射性核素疗法的低剂量辐射增强了GD2 TRAC-CAR T细胞在局部神经母细胞瘤中的疗效 |
Sodji, Q. H. |
PDF |
N/A |
Low Dose Radiation by Radiopharmaceutical Therapy Enhances GD2 TRAC-CAR T Cells Efficacy in Localized Neuroblastoma |
| 两亲分子工程化的DNA佐剂通过细胞质危险感应刺激淋巴结中强烈的I型干扰素产生，从而在小鼠和非人灵长类动物中诱导强大的细胞和体液免疫。 |
Steinbuck, M. P. |
PDF |
N/A |
Amphiphile-engineered DNA adjuvants stimulate strong type I IFN production in lymph nodes via cytosolic danger-sensing to induce potent cellular and humoral immunity in mice and non-human primates |
| 对Fc效应功能的要求可以通过广谱反应性抗α病毒抗体的结合效力来克服。 |
Callahan, V. |
PDF |
N/A |
Requirement for Fc effector function is overcome by binding potency for broadly reactive anti-alphavirus antibodies |
| 时空限制的Hippo信号传导指导肝胆细胞的命运和成熟 |
Wang, Y. |
PDF |
N/A |
Spatiotemporally restricted Hippo signalings instruct the fate and maturation of hepatobiliary cells |
| 利用成像光谱学在混合温带森林中绘制冠层叶片功能性状图 |
Gravel, A. |
PDF |
N/A |
Mapping canopy foliar functional traits in a mixed temperate forest using imaging spectroscopy |
| NANUQ+：一种用于网络估计的分治方法 |
Allman, E. S. |
PDF |
N/A |
NANUQ+: A divide-and-conquer approach to network estimation |
| 混合长度基因组测序（blend-seq）：结合短读长与低覆盖度长读长以最大化变异发现 |
Magner, R. |
PDF |
N/A |
Blended Length Genome Sequencing (blend-seq): Combining Short Reads with Low-Coverage Long Reads to Maximize Variant Discovery |
| 跨界基因组中人类睡眠相关基因直系同源基因的保守性：来自莱茵衣藻的系统基因组学证据 |
Pandi-Perumal, S. R. |
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N/A |
Cross-Kingdom Genomic Conservation of Human Sleep-Related Gene Orthologs: Phylogenomic Evidence from Chlamydomonas reinhardtii |
| 较长的内含子往往含有更多的串联重复序列，并且经历插入和删除的频率更高。 |
Homma, K. |
PDF |
N/A |
Longer Internal Exons Tend to Have More Tandem Repeats and Experience Insertions and Deletions More Frequently |