| YAP通过Rho-GTPase开关控制细胞迁移和侵袭 |
Shah, S. R. |
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N/A |
YAP controls cell migration and invasion through a Rho-GTPase switch |
| 益生菌治疗鼻腔金黄色葡萄球菌去定植的计算和体外评估 |
Tepekule, B. |
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N/A |
Computational and in vitro evaluation of probiotic treatments for nasal Staphylococcus aureus decolonization |
| 转录组数据揭示了食蚁兽和穿山甲在饮食趋同背景下几丁质酶进化的不同路径 |
Allio, R. |
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N/A |
Transcriptomic data reveal divergent paths of chitinase evolution underlying dietary convergence in anteaters and pangolins |
| 用于多重行为学和单细胞转录组学研究的确定性遗传条形码技术 |
Mendana, J. B. |
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N/A |
Deterministic Genetic Barcoding for Multiplexed Behavioral and Single-Cell Transcriptomic Studies |
| 最长命哺乳动物中的DNA修复与抗癌机制：弓头鲸 |
Firsanov, D. |
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N/A |
DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale |
| 活性粒子诱导的网络范围张力波动对脂质泡沫原组织进行重塑 |
Gu, A. A. |
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N/A |
Remodeling of lipid-foam prototissues by network-wide tension fluctuations induced by active particles |
| 解码视觉空间注意力控制 |
Meyyappan, S. |
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N/A |
Decoding Visual Spatial Attention Control |
| Tgfbr1 调控侧板中胚层和内胚层在躯干向尾部过渡期间的重组 |
Lozovska, A. |
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N/A |
Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition |
| 厘米级组织和胚胎中大量异质细胞群体的体积跨尺度成像 |
Ichimura, T. |
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N/A |
Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo |
| 免疫缺陷相关激活型PIK3R1变异的矛盾性显性负性活性 |
Tomlinson, P. R. |
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N/A |
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant |
| 脱轨细胞状态的联合表示与可视化：Decipher |
Nazaret, A. |
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N/A |
Joint representation and visualization of derailed cell states with Decipher |
| 脑网络动态在不同情境下预测惊讶时刻 |
Zhang, Z. |
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N/A |
Brain network dynamics predict moments of surprise across contexts |
| BRD4介导的内质网-线粒体接触位点的表观遗传调控受线粒体复合物III的调控。 |
Chen, B. |
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N/A |
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III |
| 在狨猴对中，性别和熟悉程度对社交凝视的动态调节 |
Xing, F. |
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N/A |
Dynamic modulation of social gaze by sex and familiarity in marmoset dyads |
| CTCF锚定的染色质环在人类减数分裂期间的动力学 |
Kaiser, V. B. |
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N/A |
CTCF-anchored chromatin loop dynamics during human meiosis |
| 从头检测高质量长读长单细胞RNA测序数据中的体细胞变异 |
Dondi, A. |
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N/A |
De novo detection of somatic variants in high-quality long-read single-cell RNA sequencing data |
| 水熊虫Hypsibius exemplaris中通过qRT-PCR比较相对转录水平的单动物、单管RNA提取方法。 |
Kirk, M. J. |
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N/A |
Single-animal, single-tube RNA extraction for comparison of relative transcript levels via qRT-PCR in the tardigrade Hypsibius exemplaris. |
| PIPETS：一种基于统计学原理、不依赖基因注释的分析方法，用于通过3'-端测序研究细菌终止机制。 |
Furumo, Q. |
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N/A |
PIPETS: A statistically informed, gene-annotation agnostic analysis method to study bacterial termination using 3'-end sequencing. |
| moPepGen：快速全面鉴定非规范肽 |
Zhu, C. |
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N/A |
moPepGen: Rapid and Comprehensive Identification of Non-canonical Peptides |
| 新胱氨酸摇篮家族中的一个典型成员是一种aECM蛋白，它在秀丽隐杆线虫中传递皮肤损伤的信号。 |
Sonntag, T. |
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N/A |
A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans |
| 优化系统发育特征向量回归中的变量选择以进行性状相关性分析 |
Chen, Z.-L. |
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N/A |
Optimizing Variable Selection in Phylogenetic Eigenvector Regression for Trait Correlation Analysis |
| 斑马鱼作为研究PERK功能在发育性疾病中的作用的模式生物：对Wolcott-Rallison综合征的启示 |
Almeida, L. M. |
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N/A |
Zebrafish as a model to study PERK function in developmental diseases: implications for Wolcott-Rallison syndrome |
| 解决SARS-CoV-2系统发育中的大流行性系统错误 |
Hunt, M. |
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N/A |
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny |
| 新型酵母共生体的设计及其在酿酒发酵生态研究中的应用 |
Pourcelot, E. |
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N/A |
Design of a new model yeast consortium for ecological studies of enological fermentation |
| Ezrin通过EGFR-AKT信号通路在细胞内小泡区室中定义了TSC复合物的激活。 |
Giamundo, G. |
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N/A |
Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling. |
| 表皮胶原蛋白主动调节感觉神经元的衰老 |
Krishna, M. |
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N/A |
Epidermal Collagen Actively Regulates the Aging of Sensory Neurons |
| 线性感知运动转换解释了人类航向估计中与反应范围相关的偏差 |
Sun, Q. |
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N/A |
A linear sensorimotor transformation accounts for response range-dependent biases in human heading estimation |
| 消化和肠腔流动的昼夜变化决定了人类大肠微生物群落的动态变化。 |
Salari, A. |
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N/A |
Diurnal variations in digestion and luminal flow determine microbial population dynamics along the human large intestine |
| 发条猩猩：微小RNA、体温调节权衡与脑容量进化。 |
Fromm, B. |
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N/A |
Clockwork Orangutan: microRNAs, thermoregulatory tradeoffs, and the evolution of brain size. |
| RNA会根据需要调整其灵活性，以便高效折叠并抵抗展开。 |
Jang, S. S. |
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N/A |
RNA adapts its flexibility to efficiently fold and resist unfolding |
| 基于人工智能的新型药物-基因-疾病相互作用识别方法，利用蛋白质-蛋白质相互作用 |
Taguchi, Y.-h. |
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N/A |
Novel artificial intelligence-based identification of drug-gene-disease interaction using protein-protein interaction |
| 片段化DNA的“深度采样”PCR揭示了克氏锥虫在慢性感染宿主中的广泛负担范围，并允许在治疗后对寄生虫负荷进行准确监测。 |
White, B. E. |
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N/A |
Serial "deep-sampling" PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected hosts and allows accurate monitoring of parasite load following treatment |
| 与淀粉样变性、溶酶体不稳定和出血相关的病理性轴突增大是阿尔茨海默病中的主要缺陷。 |
Fu, H. |
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N/A |
Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in Alzheimer's disease |
| 在热带森林实验中，树木多样性增加了地上的碳储存和通量，但对地下的碳储存和通量没有影响。 |
Schnabel, F. |
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N/A |
Tree diversity increases carbon stocks and fluxes above- but not belowground in a tropical forest experiment |
| 通过细胞类型动态系统解析不同细胞类群的作用 |
Jha, A. |
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N/A |
Disentangling the Roles of Distinct Cell Classes with Cell-Type Dynamical Systems |
| 人类微生物组的综合生物合成分析揭示了多样化的保护性核糖体肽 |
ZHANG, J. |
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N/A |
Comprehensive Biosynthetic Analysis of Human Microbiome Reveals Diverse Protective Ribosomal Peptides |
| 在猕猴视觉注意过程中小脑齿状核神经元活动的编码 |
Flierman, N. A. |
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N/A |
Encoding of cerebellar dentate neuronal activity during visual attention in rhesus macaques |
| 个体间声道的多样性影响口语语言的语音多样化 |
Moran, S. |
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N/A |
Interindividual vocal tract diversity influences the phonetic diversification of spoken languages |
| 机器学习揭示关键糖蛋白突变并快速划分拉沙病毒谱系 |
Daodu, R. O. |
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N/A |
Machine Learning Reveals Key Glycoprotein Mutations and Rapidly Assigns Lassa Virus Lineages |
| 极性建立和中心体纺锤体独立性细胞分裂的最小数学模型 |
Maxian, O. |
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N/A |
A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis |
| 通过单胺能核团内固有调制对功能上不同的输入进行多路复用，以调节放电时序 |
Lynn, M. B. |
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N/A |
Multiplexing of functionally distinct inputs by intrinsic modulation of spike timing in a monoaminergic nucleus |
| 消除常见的神经选择信号并不会使它们成为人工产物。对Frömer等人（2024年，《自然·人类行为》）的评论。 |
O'Connell, R. G. |
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N/A |
Regressing Away Common Neural Choice Signals does not make them Artifacts. Comment on Frömer et al (2024, Nature Human Behaviour) |
| 气候变化与病原体多样性之间的相互作用塑造了农业环境中地方性疾病的动力学 |
Bhandari, R. |
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N/A |
Interaction between climatic variation and pathogen diversity shape endemic disease dynamics in the agricultural settings |
| 空间转录组学的基因表达框架 |
Cao, S. |
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N/A |
A gene representation framework for spatial transcriptomics |
| 体内T细胞共调节因子B7-H4的成像揭示了前列腺癌中的促肿瘤巨噬细胞状态 |
Kumar, M. |
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N/A |
In vivo imaging of T-cell coregulator B7-H4 reveals protumor macrophage status in prostate cancer |
| 一种综合的蛋白质组学和转录组学方法揭示了新的ADAM9底物及其下游通路 |
Lu, C. |
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N/A |
An integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways |
| 模块化噬菌体T4纳米颗粒平台助力快速设计双效COVID-19-流感黏膜疫苗 |
Zhu, J. |
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N/A |
A Modular Bacteriophage T4 Nanoparticle Platform Enables Rapid Design of Dual COVID-19-Flu Mucosal Vaccines |
| 代谢微调与心脏细胞因子分泌是果蝇对高脂肪和高糖饮食的适应性反应。 |
Khamvongsa-Charbonnier, L. |
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N/A |
Metabolism fine tuning and cardiokines secretion represent adaptative responses of the heart to High Fat and High Sugar Diets in flies |
| 食物摄入增强了海马体的锋电位波纹复合体。 |
Kaya, E. |
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N/A |
Food intake enhances hippocampal sharp wave-ripples |
| EphA2 和磷酸抗原介导的 γδT 细胞对髓母细胞瘤的选择性杀伤保护了神经元和干细胞的完整性 |
Boutin, L. |
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N/A |
EphA2 and Phosphoantigen-Mediated Selective Killing of Medulloblastoma by γδT Cells Preserves Neuronal and Stem Cell Integrity |
| β-肾上腺素能阻滞剂通过胰腺β细胞中的PKA/RYR2/TRPM5途径增加cAMP并刺激胰岛素分泌，此过程在体外实验中得到验证。 |
Murao, N. |
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N/A |
β-adrenergic blockers increase cAMP and stimulate insulin secretion through a PKA/RYR2/TRPM5 pathway in pancreatic β-cells in vitro |
| 发现广谱细菌多胺解毒抑制剂作为潜在的抗毒力剂和抗生素佐剂 |
Moulding, P. B. |
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N/A |
Discovery of broad-spectrum bacterial polyamine detoxification inhibitors as potential antivirulence agents and antibiotic adjuvants |
| 人类在空间导航过程中前额叶Theta波和顶叶Alpha波振荡事件的单次试验特征 |
Cuello, M. T. |
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N/A |
Single trial characterization of frontal Theta and parietal Alpha oscillatory episodes during Spatial Navigation in humans |
| 经典的统计方法在识别乳腺癌患者生存的新靶点方面具有强大的作用。 |
Insawang, B. |
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N/A |
Classical statistical methods are powerful for the identification of novel targets for the survival of breast cancer patients |
| 利用智能手机RGB图像和LiDAR点云进行增强的叶片氮素和地上生物量评估——以中国菠菜为案例研究 |
Harikumar, A. |
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N/A |
Harnessing Smartphone RGB Imagery and LiDAR Point Cloud for Enhanced Leaf Nitrogen and Shoot Biomass Assessment - Chinese Spinach as a Case Study |
| 比较时空单细胞转录组揭示了C4草类Kranz解剖结构出现过程中预存调控的重塑 |
Zhao, C. |
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N/A |
Comparative spatiotemporal single cell transcriptomes reveal rewiring of pre-existing regulations during emergence of Kranz anatomy in C4 grasses |
| 一种组合域筛选平台揭示了表观遗传效应因子与转录扰动之间的相互作用 |
Moon, H. C. |
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N/A |
A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation |
| 有机和无机污染物及其混合物对发育期暴露斑马鱼代谢健康和基因表达的影响 |
Berube, R. |
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N/A |
Effects of organic and inorganic contaminants and their mixtures on metabolic health and gene expression in developmentally exposed zebrafish |
| 利用多环境试验育种数据优化基因型特异性参数评估木薯作物生长模型 |
Okoma, P. M. |
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N/A |
Evaluating a Cassava Crop Growth Model by Optimizing Genotypic-Specific Parameters Using Multi-environment Trial Breeding Data |
| C3-C3aR轴调控肺泡巨噬细胞的训练免疫 |
Earhart, A. P. |
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N/A |
The C3-C3aR axis modulates trained immunity in alveolar macrophages |
| Squeakuences：一种便携式工具，用于格式化无瑕疵的序列，以消除生物信息学软件的不兼容性 |
Lane, L. E. |
PDF |
N/A |
Squeakuences: a portable tool for formatting squeaky-clean sequences to eliminate bioinformatic software incompatibilities |
| 探索恶性疟原虫二氢叶酸还原酶的适应性景观：抗叶酸耐药性的进化见解 |
Muzata, D. |
PDF |
N/A |
Navigating the Fitness Landscapes of Plasmodium falciparum Dihydrofolate Reductase: Evolutionary Insights into Antifolate Resistance |
| 一种全球性的多巴胺能学习率能够使适应性觅食在众多选择中进行。 |
Grima, L. L. |
PDF |
N/A |
A global dopaminergic learning rate enables adaptive foraging across many options |
| 验证DXS作为分枝杆菌中具有吸引力的药物靶点 |
Maila, T. |
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N/A |
Validation of DXS as an attractive drug target in mycobacteria |
| 神经溶酶体定位与功能的小分子调节剂可解决培养的人类神经元中与阿尔茨海默病相关的病理 |
Snead, A. M. |
PDF |
N/A |
Small molecule modulator of neuronal lysosome positioning and function resolves Alzheimers Disease-linked pathologies in cultured human neurons |
| 小鼠新皮层深层6层兴奋性神经元的共识定义 |
Kim, S.-J. |
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N/A |
A consensus definition for deep layer 6 excitatory neurons in mouse neocortex |
| 皮质纹状体投射招募黑质外侧部多巴胺能神经元用于听觉威胁记忆 |
Sansalone, L. |
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N/A |
Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories |
| 保守开花基因的顺式调控元件的拮抗作用介导了发育的稳健性。 |
Lanctot, A. |
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N/A |
Antagonizing cis-regulatory elements of a conserved flowering gene mediate developmental robustness |
| 对蝾螈Y染色体转换的鉴定未能支持Triturus平衡致死系统起源于性染色体的观点 |
France, J. M. |
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N/A |
Identification of Y-chromosome turnover in newts fails to support a sex chromosome origin for the Triturus balanced lethal system |
| xIV-LDDMM工具包：一套基于图像-变分技术的工具，用于在多尺度上同时表示和映射三维成像和空间组学数据 |
Stouffer, K. |
PDF |
N/A |
xIV-LDDMM Toolkit: A Suite of Image-Varifold Based Technologies for Representing and Mapping 3D Imaging and Spatial-omics Data Simultaneously Across Scales |
| 一种高山植物在冰川后迅速扩张的范围内没有表现出遗传多样性的下降。 |
Urquhart-Cronish, M. |
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N/A |
An alpine plant shows no decrease in genetic diversity associated with rapid post-glacial range expansion |
| 丛枝菌根真菌中转座元件的分析支持其与植物病原真菌在进化上的相似性 |
Oliveira, J. I. |
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N/A |
Analyses of transposable elements in arbuscular mycorrhizal fungi support evolutionary parallels with fungal plant pathogens |
| 对丛枝菌根真菌中转座子元素的分析支持其与丝状植物病原体在进化上的平行性。 |
Oliveira, J. I. |
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N/A |
Analyses of transposable elements in arbuscular mycorrhizal fungi support evolutionary parallels with filamentous plant pathogens |
| SeedMatExplorer：拟南芥种子成熟转录组图谱 |
Artur, M. A. S. |
PDF |
N/A |
SeedMatExplorer: The transcriptome atlas of Arabidopsis seed maturation |
| PII蛋白与BADC和BCCP蛋白的相互作用共同调控拟南芥中的脂质和氮代谢 |
Garneau, M. G. |
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N/A |
PII interactions with BADC and BCCP proteins co-regulate lipid and nitrogen metabolism in Arabidopsis |
| 5-甲基胞嘧啶DNA糖基化酶ROS1对抗拟南芥胚乳中亲本特异性DNA甲基化 |
Hemenway, E. A. |
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N/A |
The 5-methylcytosine DNA glycosylase ROS1 antagonizes parent-of-origin specific DNA methylation in Arabidopsis endosperm |
| 高温和微生物群落条件影响大豆基因表达 |
Van der Laan, L. |
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N/A |
High Temperature and Microbiome Conditions Affect Gene Expression in Soybean |
| 红藻Galdieria sulphuraria NIES-3638中PSI-LHCI复合物的LHCI蛋白多样性的生化证据 |
Nagao, R. |
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N/A |
Biochemical evidence for the diversity of LHCI proteins in PSI-LHCI from the red alga Galdieria sulphuraria NIES-3638 |
| 衰老促使植物器官中DNA甲基化衰减的程序启动 |
Dai, D. |
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N/A |
Aging drives a program of DNA methylation decay in plant organs |
| PATROL1介导的H+-ATP酶转运通过优化根和叶的功能，在干旱条件下促进植物生长。 |
Katsuhama, N. |
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N/A |
PATROL1-mediated H+-ATPase translocation boosts plant growth under drought by optimizing root and leaf functions |
| 番茄根系对细菌来源的肽表现出明显的、与发育阶段相关的反应 |
Leuschen-Kohl, R. L. |
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N/A |
Tomato roots exhibit distinct, development-specific responses to bacterial-derived peptides |
| 压缩力通过ERK信号通路诱导衰老的人类真皮成纤维细胞的表观遗传激活 |
Liu, H. |
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N/A |
Compressive forces induce epigenetic activation of aged human dermal fibroblasts through ERK signalling pathway |
| KLF7调控的ITGA2作为抑制口腔癌干细胞的治疗靶点 |
QI, X. |
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N/A |
KLF7-Regulated ITGA2 as a Therapeutic Target for Inhibiting Oral Cancer Stem Cells |
| 靶向黑色素瘤细胞的能量代谢：FX-11作为线粒体解偶联剂 |
Preis, J. R. |
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N/A |
Targeting the energy metabolism of melanoma cells: FX-11 acts as a mitochondrial uncoupler |
| 一种罕见的造血干细胞来源的巨核细胞祖细胞通过增强的存活而积累，并在衰老时促进血栓形成加剧 |
Manso, B. A. |
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N/A |
A rare HSC-derived megakaryocyte progenitor accumulates via enhanced survival and contributes to exacerbated thrombopoiesis upon aging |
| 草酸铁钾纳米颗粒在小鼠模型中可预防人类血液凝固和血栓形成 |
Yenurkar, D. |
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N/A |
Potassium ferric oxalate nanoparticles prevent human blood clotting and thrombosis in a mouse model |
| 基于EEG连接组的健康受试者非言语智力水平的预测建模 |
Pashkov, A. A. |
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N/A |
EEG connectome-based predictive modeling of nonverbal intelligence level in healthy subjects |
| 通过Sac1依赖的PI(4)P和胆固醇的共同调控来控制高尔基体V-ATPase |
Zhou, X. |
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N/A |
Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol |
| TFG环复合体在神经元货物运输中具有多种作用 |
Zhang, Z. |
PDF |
N/A |
Multiple roles for TFG ring complexes in neuronal cargo trafficking |
| 微管锚定因子NEDD1与γ-微管蛋白环复合物结合的结构 |
Munoz Hernandez, H. |
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N/A |
Structure of the microtubule anchoring factor NEDD1 bound to the γ-tubulin ring complex |
| 用于冷冻电镜断层成像颗粒挑选机器学习竞赛的开源工具 |
Harrington, K. I. |
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N/A |
Open-source Tools for CryoET Particle Picking Machine Learning Competitions |
| 中和抗体对SARS-CoV-2 JN.1变种KP.3、KP.3.1.1、LB.1和XEC的逃逸 |
Sano, K. |
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N/A |
Neutralizing antibody evasion of SARS-CoV-2 JN.1 derivatives KP.3, KP.3.1.1, LB.1, and XEC |
| 两种致病真菌中将单倍体染色体分配到不同细胞核的过程 |
Li, X. |
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N/A |
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi |
| 通过额外结合髓鞘少突胶质细胞糖蛋白（一种中枢神经系统特异性蛋白），延长抗体在大脑中的半衰期 |
Cuypers, M.-L. |
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N/A |
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein |
| 用于DNA数据存储中无PCR随机访问的纳米孔测序自适应采样 |
Sokolovskii, R. |
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N/A |
Adaptive sampling in nanopore sequencing for PCR-free random access in DNA data storage |
| DNA-SaM是一种用于大规模数据存储的强大系统。 |
Huang, X. |
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N/A |
DNA-SaM, a robust system for large-scale data storage |
| A群链球菌碳水化合物生物合成基因的自然变异影响宿主-病原体相互作用 |
Tamminga, S. M. |
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N/A |
Natural variation of the streptococcal Group A carbohydrate biosynthesis genes impacts host-pathogen interaction |
| 粘附侵袭性大肠杆菌对环丙沙星的持久性表型，揭示了高持久性菌株 |
Perez-Villalobos, V. |
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N/A |
Persistence phenotype of adherent-invasive Escherichia coli in response to ciprofloxacin, revealing high-persistence strains |
| 临床环境中大肠埃希菌菌株的自动监测 |
Rodriguez Palomo, R. |
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N/A |
Automatic surveillance of Escherichia coli bacteriological strains within clinical settings |
| 单分子成像揭示了RNase E在埃希氏大肠杆菌中的定位和扩散过程中，膜结合基序和C端结构域的作用 |
Troyer, L. |
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N/A |
Single-molecule imaging reveals the role of membrane-binding motif and C-terminal domain of RNase E in its localization and diffusion in Escherichia coli |
| 直接脂质相互作用调控SARS-CoV-2 M蛋白的构象动态变化及病毒组装 |
Dutta, M. |
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N/A |
Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly |
| 疟原虫无性复制和热耐受性的关键作用依赖于HSP40 |
Roper, B. |
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N/A |
Essential role for HSP40 in asexual replication and thermotolerance of malaria parasites |
| PgtE蛋白酶使致病性沙门氏菌能够逃避C3介导的血清和嗜中性粒细胞杀伤作用。 |
Lee, M. H. |
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N/A |
PgtE protease enables virulent Salmonella to evade C3-mediated serum and neutrophil killing |
| 大肠杆菌中的硫化物响应转录调控 |
Hori, K. |
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N/A |
Sulfide-responsive transcription control in Escherichia coli |
| 23S rRNA螺旋69的远端核糖2'-O-甲基化预先确定了核糖体亚基界面处的缠霉素药物结合口袋 |
Nandi, S. |
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N/A |
Distant Ribose 2'-O-Methylation of 23S rRNA Helix 69 Pre-Orders the Capreomycin Drug Binding Pocket at the Ribosome Subunit Interface |
| 铜绿假单胞菌必需基因扰动，使其在哺乳动物宿主环境中变得脆弱 |
Prasad, N. K. |
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N/A |
Pseudomonas aeruginosa essential gene perturbations that confer vulnerability to the mammalian host environment |
| 慢性分枝杆菌感染会引发巨噬细胞衰老。 |
Scarpa, E. |
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N/A |
Chronic mycobacteria infection triggers macrophage senescence |
| 原核生物抗病毒防御中利他主义的生态决定因素 |
Biba, D. A. |
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N/A |
Ecological Determinants of Altruism in Prokaryote Antivirus Defense |
| 比较RT-qPCR和qPCR揭示了柑橘黄龙病菌（Candidatus Liberibacter asiaticus）的早期感染、低拷贝感染以及相对细胞活性。 |
Patterson, R. |
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N/A |
Comparative RT-qPCR and qPCR reveals early infection, low-titer infection, and relative cell activity of the HLB bacterium, Candidatus Liberibacter asiaticus |
| 通过高速原子力显微镜直接观察亨廷顿蛋白淀粉样形成中的二次成核现象 |
van Ewijk, C. |
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N/A |
Direct observation of secondary nucleation in huntingtin amyloid formation by High-Speed Atomic Force Microscopy |
| 在不同发育阶段，本地适应的内陆一年生和沿海多年生生态型之间的基因表达差异 |
Olsen, J. D. |
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N/A |
Gene expression divergence between locally adapted inland annual and coastal perennial ecotypes of Mimulus guttatus across developmental stages |
| 改进的分裂质粒编辑器能够实现高效的体内基因编辑 |
Wei, R. |
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N/A |
Improved split prime editors enable efficient in vivo genome editing |
| 鞭毛内运输蛋白IFT172含有一个C端泛素结合的U型盒样结构域，参与纤毛信号传导。 |
Zacharia, N. K. |
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N/A |
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling |
| Blm10的结构：13S蛋白酶体中间体揭示了蛋白酶体核心颗粒的并行组装途径 |
Kaur, M. |
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N/A |
Structure of Blm10:13S proteasome intermediate reveals parallel assembly pathways for the proteasome core particle |
| 缺乏多接头区域外限制位点的酿酒酵母极简整合穿梭载体 |
Scutteri, L. |
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N/A |
Minimal integrating shuttle vectors for Saccharomyces cerevisiae depleted of restriction sites outside the polylinker region |
| 谷氨酸棒杆菌系统代谢工程用于高效L-色氨酸生产 |
Dong, Y. |
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N/A |
Systems metabolic engineering of Corynebacterium glutamicum for efficient L-tryptophan production |
| ITD对于（有偏差的）人类听觉方位感知是充分的 |
Azevedo, A. C. P. F. O. d. |
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N/A |
Sufficiency of ITD for (biased) human auditory azimuthal perception |
| 腹侧苍白球-伏隔核壳核通路的化学遗传学操控可调节雌性大鼠的蔗糖摄入，且与动机无关。 |
Peroutka, M. M. |
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N/A |
Chemogenetic manipulation of the ventral pallidum-nucleus accumbens shell pathway modulates sucrose consumption independent of motivation in female rats. |
| Contactin-1 是周围神经网络结构的关键神经细胞表面受体。 |
Sinha, A. |
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N/A |
Contactin-1 is a critical neuronal cell surface receptor for perineuronal net structure |
| 特异性环状RNA circDS-1通过调控双态转变和毒力，促进塔罗霉菌（Talaromyces marneffei）的适应性进化 |
Hu, X. |
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N/A |
Species-specific circular RNA circDS-1 enhances adaptive evolution in Talaromyces marneffei through regulation of dimorphic transition and virulence |
| 多组学单细胞分析揭示了HIV-1早期感染中持续存在和宿主免疫反应异常的关键调控因子 |
Lee, D. |
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N/A |
Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early Infection |
| 金黄色葡萄球菌与铜绿假单胞菌之间的多微生物相互作用促进了生物膜的形成和在慢性伤口感染中的持久性。 |
Keim, K. C. |
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N/A |
Polymicrobial interactions between Staphylococcus aureus and Pseudomonas aeruginosa promote biofilm formation and persistence in chronic wound infections |
| 一种模型，源自脊髓损伤患者的混合物种尿道导管生物膜 |
Noorian, P. |
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N/A |
A model, mixed-species urinary catheter biofilm derived from spinal cord injury patients |
| 结构导向的突变分析揭示了小鼠胰岛素受体5'UTR IRES功能中一个关键的保守区域 |
Dahl, W. B. |
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N/A |
Structure-informed mutagenesis identifies a conserved region critical for mouse insulin receptor 5'UTR IRES function |
| 来自曲霉的疏水蛋白介导真菌与微塑料的相互作用 |
Klauer, R. R. |
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N/A |
Hydrophobins from Aspergillus mediate fungal interactions with microplastics |
| 大西洋鲑鱼对IPNV和ISAV病毒反应中宿主蛋白的不同泛素化 |
Stewart, R. |
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N/A |
Differential Ubiquitination of Host Proteins in Response to IPNV and ISAV viruses in Atlantic salmon |
| 维生素B12通过改善丙酸分解和一碳循环代谢途径，部分挽救了秀丽隐杆线虫Ephrin突变体胚胎细胞迁移缺陷。 |
Ganjawala, T. H. |
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N/A |
Vitamin B12 partially rescues embryonic cell migration defects in C. elegans ephrin mutants by improving both propionic acid breakdown and one-carbon cycle metabolic pathways |
| 气候和捕食压力驱动南非狒狒（Papio ursinus）昼夜活动模式的变异 |
Dzingwena, L. |
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N/A |
Climate and predation drive variation of diel activity patterns in chacma baboons (Papio ursinus) across southern Africa |
| 非尿素选择性GIRK通道激活剂的低剂量改善了由淀粉样β寡聚体破坏的海马依赖性突触可塑性和记忆 |
Mulero-Franco, J. |
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N/A |
Low dose of a non-urea selective GIRK channel activator improves hippocampal-dependent synaptic plasticity and memory disrupted by amyloid-β oligomers |
| 一种神经网络模型，能够在秀丽隐杆线虫中生成依赖于盐浓度记忆的趋化行为 |
Hironaka, M. |
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N/A |
A neural network model that generates salt concentration memory-dependent chemotaxis in Caenorhabditis elegans |
| 选择和结果的神经编码受到眶额皮层中不确定性的调节，但在次级运动皮层中则不受此影响。 |
Romero-Sosa, J. L. |
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N/A |
Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex |
| 小胶质细胞通过胞外核苷酸酶CD39调节脑血流量和神经血管耦合 |
Fu, Z. |
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N/A |
Microglia modulate cerebral blood flow and neurovascular coupling through ectonucleotidase CD39 |
| HA1（一种普罗布考类似物）和ApoC3 siRNA对db/db小鼠脂蛋白-淀粉样蛋白代谢、神经血管完整性及认知功能的影响 |
Sharif, A. |
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N/A |
Effects of HA1 (a Probucol Analogue) and ApoC3 siRNA on Lipoprotein-Amyloid Metabolism, Neurovascular Integrity and Cognitive Function in db/db Mice |
| 尼古丁和吸烟暴露对发育期和成年期小鼠大脑的分子影响 |
Gonzalez-Padilla, D. |
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N/A |
Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain |
| 用于体外和体内神经应用的柔性3D剪纸探针 |
Jung, M. |
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N/A |
Flexible 3D kirigami probes for in vitro and in vivo neural applications |
| 口服Boldine可减轻小鼠神经损伤模型中的胶质细胞激活并预防神经性疼痛 |
Pan, J. |
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N/A |
Oral Boldine Administration Attenuates Glia Activation and Prevents Neuropathic Pain in a Murine Spared Nerve Injury Model |
| 线粒体功能障碍在帕金森病发病机制中损害核孔复合体 |
Riaz, Z. |
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N/A |
Mitochondrial dysfunction Impairs the Nuclear Pore Complex in Parkinson's Disease Pathogenesis |
| 通过GluN2C/GluN2D NMDA受体增强选择性增强中间神经元网络和伽马频段功率 |
Camp, C. R. |
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N/A |
Selective Enhancement of the Interneuron Network and Gamma-Band Power via GluN2C/GluN2D NMDA Receptor Potentiation |
| DNA复制叉速度在皮质神经发生中起到引擎作用 |
Wang, J. |
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N/A |
DNA replication fork speed Acts as an Engine in Cortical Neurogenesis |
| 细胞类型特异性表观基因组编辑在发育中的小鼠皮层中促进中间前体细胞增殖，通过在lncSox1启动子区域靶向H3K9乙酰化 |
Sokpor, G. |
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N/A |
Targeted H3K9 acetylation at lncSox1 promoter by cell type-specific epigenome editing promotes intermediate progenitor proliferation in developing mouse cortex |
| 跨物种神经解剖协变性别差异分析：人类与小鼠的研究 |
Pham, L. |
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N/A |
A cross-species analysis of neuroanatomical covariance sex difference in humans and mice |
| 空间单细胞图谱揭示了扣带-岛叶区域中神经元身份和兴奋性的关键调控因子 |
Fodoulian, L. |
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N/A |
A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability |
| 淀粉样蛋白-β抑制内皮细胞中β-连环蛋白信号通路，损害血管屏障完整性 |
Leasure, J. W. |
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N/A |
Inhibition of β-catenin signaling by Amyloid-β in endothelial cells impairs vascular barrier integrity |
| 在小鼠初级视觉皮层柱中，高效的层状分布相互作用和方向选择性 |
Zou, L. |
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N/A |
Efficient laminar-distributed interactions and orientation selectivity in the mouse V1 cortical column |
| 前注意转移不受扫视幅度的调节 |
Zimmermann Bortoluzzi, L. |
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N/A |
Presaccadic attentional shifts are not modulated by saccade amplitude |
| 解开眼球运动相关的耳膜振荡（EMREOs）：扫视方向和中耳特性如何塑造振幅和时间过程 |
Sotero Silva, N. |
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N/A |
Unraveling eye movement-related eardrum oscillations (EMREOs): how saccade direction and middle ear properties shape amplitude and time course |
| 通过多模态对比学习进行体内细胞类型和脑区分类 |
Yu, H. |
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N/A |
In vivo cell-type and brain region classification via multimodal contrastive learning |
| 一种依赖于CCDC112的新型精子中段形成和附睾成熟过程 |
O'Bryan, M. K. |
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N/A |
A novel CCDC112-dependent process of sperm midpiece formation and epididymal maturation |
| 化学感觉在果蝇中驱动不同的社会行为 |
Wu, B. |
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N/A |
Chemosensation drives divergent social behavior in Drosophila |