| 序列和化学特异性定义了固有无序区域的功能景观 |
Langstein-Skora, I. |
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Sequence- and chemical specificity define the functional landscape of intrinsically disordered regions |
| 一种校正转录组关联研究中预测表达不确定性的方法 |
Majumdar, A. |
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A method to adjust for the uncertainty of predicted expression in transcriptome-wide association study |
| DnaB-复制解旋酶-噬菌体{lambda}P装载复合物的自抑制构象 |
Brown, D. |
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An Autoinhibited Conformation of the DnaB-Replicative Helicase - phage {lambda}P Loader Complex |
| 探究数学学习困难儿童的前额叶-顶叶网络及激活情况：不同缺陷特征的案例研究 |
Wang, F. |
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Investigating Frontoparietal Networks and Activation in Children with Mathematics Learning Difficulties: Cases with Different Deficit Profiles |
| 小脑浦肯野细胞控制斑马鱼（Danio rerio）幼体的姿势 |
Auer, F. |
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Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (Danio rerio) |
| 种群大小与生殖寿命相互作用，共同塑造了种系突变率。 |
Zhu, L. |
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Population size interacts with reproductive longevity to shape the germline mutation rate |
| 未配对和异质性临床流式细胞术数据的整合 |
Phuycharoen, M. |
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Integration of Unpaired and Heterogeneous Clinical Flow Cytometry Data |
| 组合预训练提高了计算效率，并在复杂任务上与动物行为相匹配。 |
Hocker, D. L. |
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Compositional pretraining improves computational efficiency and matches animal behavior on complex tasks |
| 通过随机连接的前馈网络中的树突计算来区分神经集合模式 |
Somashekar, B. P. |
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Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks |
| HistoGWAS：一种用于组织学队列中组织表型自动化遗传分析的AI驱动框架 |
Chaudhary, S. |
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HistoGWAS: An AI-enabled Framework for Automated Genetic Analysis of Tissue Phenotypes in Histology Cohorts |
| 新热带生物多样性指标的基因组学：两种蝴蝶辐射具有猖獗的染色体重排和杂交现象 |
van der Heijden, E. S. |
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Genomics of Neotropical biodiversity indicators: two butterfly radiations with rampant chromosomal rearrangements and hybridisation |
| 质心工作组件可能为任何行走条件下的首选行走速度提供估计 |
Hosseini-Yazdi, S.-S. |
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Center of Mass Work Components May Offer Estimates for Preferred Walking Speeds for Any Walking Conditions |
| 线粒体直接重复序列减少作为增强人类长寿的策略：常见重复序列的案例 |
Shamanskiy, V. A. |
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Mitochondrial direct repeat reduction as a strategy for enhancing human longevity: the case of the common repeat |
| 空间转录组学基因表示框架 |
Cao, S. |
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A framework for gene representation on spatial transcriptomics |
| 少突胶质细胞利用突触后蛋白来协调在不同神经递质类别轴突上的髓鞘形成。 |
Carey, N. |
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Oligodendrocytes use post-synaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes |
| 解码空间组织结构：一种可扩展的多重成像分析贝叶斯主题模型 |
Peng, X. |
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Decoding Spatial Tissue Architecture: A Scalable Bayesian Topic Model for Multiplexed Imaging Analysis |
| MMP21作为一种流体流动输送的形态发生素，在发育过程中赋予生物体左右对称性。 |
Ott, T. |
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MMP21 behaves as a fluid flow transported morphogen to impart laterality during development |
| 冰川消退后，全浮游栉水母Mnemiopsis的快速物种形成 |
Ketchum, R. N. |
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Rapid speciation in the holopelagic ctenophore Mnemiopsis following glacial recession |
| FoldMark：通过水印技术保护蛋白质生成模型 |
ZHANG, Z. |
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FoldMark: Protecting Protein Generative Models with Watermarking |
| 细胞类型特异性表观基因组编辑在发育中的小鼠皮层中促进中间祖细胞增殖，通过在lncSox1启动子处靶向H3K9乙酰化 |
Sokpor, G. |
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Targeted H3K9 acetylation at lncSox1 promoter by cell type-specific epigenome editing promotes intermediate progenitor proliferation in developing mouse cortex |
| 使用PANDORA进行MHC II类分子的双向肽构象预测 |
Rademaker, D. T. |
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Bidirectional Peptide Conformation Prediction for MHC Class II using PANDORA |
| 建模溶瘤痘苗病毒疗法突显了中性粒细胞对肿瘤抑制的影响 |
Satani, S. |
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Modeling Oncolytic Vaccinia Virus Therapy Highlights Neutrophil Impact on Tumor Suppression |
| OsMORF蛋白特异性地促进双定位RNA编辑因子OsPGL1与其目标RNA的结合。 |
Xiao, H. |
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OsMORF protein selectively promotes the dual-localized RNA editing factor OsPGL1 binding to its target RNA |
| RBPMS和RBPMS2协同作用以保护心脏剪接 |
Wu, T. |
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RBPMS and RBPMS2 Cooperate to Safeguard Cardiac Splicing |
| 比较留尼汪岛上的白纹伊蚊和致倦库蚊的病毒群落 |
Francois, S. |
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Contrasted viral communities between Aedes albopictus and Culex quinquefasciatus in La Reunion Island |
| 一种多价适配机制驱动蛋白酶体的核输入 |
Brunner, H. L. |
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A multivalent adaptor mechanism drives the nuclear import of proteasomes |
| 早发性骨关节炎诱导的COL2A1 p.Arg719Cys人类软骨模型揭示了病理驱动性基质缺陷及内质网蛋白质稳态网络未能识别缺陷型前胶原-II |
Yammine, K. M. |
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Human cartilage model of the precocious osteoarthritis-inducing COL2A1 p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II |
| 细胞命运决定与人类GATA1和GATA2谱系决定转录因子中竞争性转录单元的变化相关联。 |
Anderson, E. M. |
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Cell fate determination is associated with changes in competing transcriptional units in the human GATA1 and GATA2 lineage-determining transcription factors |
| 对具有多个等位基因的位点进行选择的综合表示，允许复杂的基因型适应性形式 |
Vellnow, N. |
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A comprehensive representation of selection at loci with multiple alleles that allows complex forms of genotypic fitness |
| 小分子奥昔布宁可挽救复杂III缺陷型MPCs的增殖能力 |
Qu, Y. |
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Small molecule oxybutynin rescues proliferative capacity of complex III-defective MPCs |
| 从嗅球局部场电位推断呼吸节律的挑战 |
Rafilson, S. E. |
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Challenges in inferring breathing rhythms from olfactory bulb local field potentials |
| 针对促肾上腺皮质激素释放激素受体1型（CRHR1）神经元：验证新型转基因Crhr1-FlpO小鼠的特异性 |
Hardy, M. |
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Targeting Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Neurons: Validating the Specificity of a Novel Transgenic Crhr1-FlpO Mouse |
| 苍白球外侧部与皮层之间的投射涉及运动和非运动区域。 |
Ferenczi, E. A. |
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Projections between the globus pallidus externa and cortex span motor and non-motor regions |
| 通过单肽能神经元中频率依赖性递质切换编码对立效价 |
Kim, D.-I. |
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Encoding opposing valences through frequency-dependent transmitter switching in single peptidergic neurons |
| 双色外显子报告系统揭示了果蝇神经元中电压门控钙离子通道剪接异构体的多样性 |
Macleod, G. T. |
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Bichromatic exon-reporters reveal voltage-gated Ca2+-channel splice-isoform diversity across Drosophila neurons in vivo |
| 不同的脑电图预处理流程可能导致关于皮层兴奋/抑制比率的结论相互矛盾。 |
Racz, F. S. |
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Alternative EEG pre-processing pipelines can lead to conflicting conclusions regarding cortical excitation/inhibition ratio |
| 人脑中非周期性神经活动的发展 |
Cross, Z. R. |
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The development of aperiodic neural activity in the human brain |
| ERP和神经振荡能否用于区分生态有效运动模型中熟练和非熟练选手的表现？ |
Winstanley, M. |
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Can ERPs and neural oscillations be used to differentiate skilled and unskilled player performance in an ecologically valid sporting model? |
| 前扣带回神经元显示出与前额叶眼区的亚区特异性相互作用，这一发现是通过结合逆向刺激和静息态成像技术揭示的。 |
Babapoor-Farrokhran, S. |
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Anterior cingulate neurons display subregion-specific interaction with frontal eye fields as revealed by combined antidromic stimulation and resting state imaging |
| 中央杏仁核谷氨酸对降钙素基因相关肽反应的性别差异 |
Lorsung, R. |
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Sex differences in central amygdala glutamate responses to calcitonin gene-related peptide |
| 回顾性注意可以触发视觉感知，而不依赖于线索意识或目标报告。 |
Li, Y. |
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Retrospective Attention Can Trigger Visual Perception Without Dependence on Either Cue Awareness or Target Reporting |
| 经过训练自我给药可卡因或酒精的大鼠中，内侧前额叶皮质神经递质对促进复发和抑制复发的线索的反应 |
Nedelescu, H. |
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Medial prefrontal cortical neurotransmitters reactive to relapse-promoting and relapse-suppressing cues in rats trained to self-administer cocaine or alcohol |
| 循环事件的神经上下文恢复 |
Broitman, A. W. |
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Neural Context Reinstatement of Recurring Events |
| 一种整合了偏向竞争和强化学习的视觉注意力神经网络模型 |
Morgan, J. M. |
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A Neural Network Model of Visual Attention Integrating Biased Competition and Reinforcement Learning |
| 自然猪宿主中呼吸道冠状病毒的发病机制和免疫反应 |
Sedaghat-Rostami, E. |
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Pathogenesis and immune response to respiratory coronaviruses in their natural porcine host |
| 真菌感染风险条件下常用药物促进白色念珠菌耐药性或抗药性 |
Obermeier, M. |
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Drugs Commonly Used in Fungal Infection Risk Conditions Promote Drug Tolerance or Resistance in Candida albicans |
| Drospondin是一种新发现的由神经胶质细胞分泌的糖蛋白，它调控果蝇神经系统的发育和功能。 |
Rojo-Cortes, F. |
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Drospondin, a novel glial-secreted glycoprotein, controls the development and function of the Drosophila nervous system |
| 进化保守的DNA甲基化的遗传基础、定量性质及功能相关性 |
Dong, Z. |
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Genetic Basis, Quantitative Nature, and Functional Relevance of Evolutionarily Conserved DNA Methylation |
| 基于纳米孔检测DNA甲基化的工具综合基准测试 |
Kulkarni, O. |
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Comprehensive benchmarking of tools for nanopore-based detection of DNA methylation |
| 人类26S蛋白酶体中AAA+ ATP酶马达状态的结构景观揭示了TXNL1的构象特异性结合 |
Martin, A. |
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Structural landscape of AAA+ ATPase motor states in the substrate-degrading human 26S proteasome reveals conformation-specific binding of TXNL1 |
| DnaB 和 DciA：解旋酶在单链 DNA 上的装载和迁移机制 |
Gao, N. |
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DnaB and DciA: Mechanisms of Helicase Loading and Translocation on ssDNA |
| 植物γ-谷氨酰肽酶1的晶体结构及其在硫代谢中的双重作用和对氧化应激调控的启示 |
Sone, K. |
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Crystal structure of plant γ-glutamyl peptidase 1 with dual roles in sulfur metabolism and implications for oxidative stress regulation |
| 语言模型在原核生物中生成顺式调控元件 |
Xia, Y. |
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Language model generates cis-regulatory elements across prokaryotes |
| RIBOSS通过结合长读长和短读长转录组及翻译组分析，检测新的翻译事件。 |
Lim, C. S. |
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RIBOSS detects novel translational events by combining long- and short-read transcriptome and translatome profiling |
| 转化生长因子-β诱导的ERK和SMAD通路的计算建模与分析 |
Chung, S. |
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Computational Modeling and Analysis of the TGF-β-induced ERK and SMAD Pathways |
| 肠道粪肠球菌的易位通过C型凝集素受体Mincle训练骨髓髓系祖细胞 |
Robles-Vera, I. |
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Translocation of gut Enterococcus faecalis trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle |
| 表型高通量筛选鉴定出肠道微生物胆碱代谢的调节因子 |
Woo, A. Y. M. |
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Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism |
| 原生动物和哺乳动物吞噬细胞对新生隐球菌吞噬反应的共性与差异表明，宿主细胞代谢是其在细胞内生存的目标。 |
Dragotakes, Q. |
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Commonalities and differences in the Cryptococcus neoformans response to ingestion by protozoal and mammalian phagocytic cells suggests host cell metabolism as a target for intracellular survival |
| 微生物差异能准确识别小鼠中的全球SERT KO表型 |
Leitman, M. |
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Microbial Differences Accurately Identifies Global SERT KO Phenotype in Mice |
| 评估未充分表征环境中的宏基因组分析：点亮微生物暗物质需要什么？ |
Nickols, W. A. |
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Evaluating metagenomic analyses for undercharacterized environments: what's needed to light up the microbial dark matter? |
| 从孙德尔本斯采集的银叶树根际中固氮细菌的分离、鉴定与鉴定 |
Rimi, A. A. |
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N/A |
Isolation, Characterization, and Identification of Nitrogen Fixing Bacteria from Rhizosphere of Sonneratia apetala Collected from Sundarbans |
| 评估qPCR、dPCR和ddPCR在估算鸣禽血液和精子细胞中线粒体DNA拷贝数的可靠性和准确性 |
Bagdonaite, L. |
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N/A |
Assessing reliability and accuracy of qPCR, dPCR and ddPCR for estimating mtDNA copy number in songbird blood and sperm cells |
| perilipin 5 磷酸化对于禁食状态下肝脏脂质代谢基因的上调并非必需，但在雄性小鼠中对胰岛素受体底物2的表达是必需的。 |
Bovee, C. |
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Perilipin 5 Phosphorylation is Dispensable for Upregulation of Hepatic Lipid Metabolism Genes upon Fasting but Required for Insulin Receptor Substrate 2 Expression in Male Mice |
| 在多物种背景下解构两种入侵者之间的适应性差异 |
Freire, T. F. A. |
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N/A |
Unpacking fitness differences between two invaders in a multispecies context |
| 使用分子条形码进行精确谱系追踪显示了伊维菌素抗性在线虫中的适应性权衡 |
Stevenson, Z. C. |
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Precise Lineage Tracking Using Molecular Barcodes Demonstrates Fitness Trade-offs for Ivermectin Resistance in Nematodes |
| 一种共识的变异到功能评分，用于为疾病优先考虑功能变异 |
Fabiha, T. |
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N/A |
A consensus variant-to-function score to functionally prioritize variants for disease |
| 新型组成型平滑肌细胞特异性Myh11驱动Cre小鼠模型的生成 |
Dong, K. |
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Generation of a novel constitutive smooth muscle cell-specific Myh11-driven Cre mouse model |
| TissueMosaic 通过自监督表示学习，实现了空间转录组学数据集的跨样本差异分析。 |
Kambhampati, S. |
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TissueMosaic enables cross-sample differential analysis of spatial transcriptomics datasets through self-supervised representation learning |
| 苯乙酸在陆地植物中的代谢：新途径与代谢物 |
Hladik, P. |
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N/A |
Phenylacetic acid metabolism in land plants: novel pathways and metabolites |
| 使用噬菌体展示技术鉴定靶向蛋白质-蛋白质相互作用共价环状肽抑制剂的鉴定 |
Wang, S. |
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Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein-Protein Interactions Using Phage Display |
| 类胡萝卜素色素通过光捕获和光循环加速，增强了视紫红质介导的光合作用。 |
Fujiwara, T. |
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Carotenoid pigments enhance rhodopsin-mediated phototrophy by light-harvesting and photocycle-accelerating |
| 一种细菌细胞壁修复和修饰系统，以抵抗宿主抗菌因子 |
Burnier, J. |
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A bacterial cell wall repair and modification system to resist host antibacterial factors |
| GpsB相关调节因子对PBP1a的表征揭示了肺炎链球菌细胞壁重塑复合体的组织结构 |
Millat, H. |
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Characterization of a GpsB-associated regulator of PBP1a reveals the organization of the cell wall remodeling complex of Streptococcus pneumoniae |
| 分子动力学模拟中蛋白质-脂质相互作用的驻留时间的贝叶斯非参数分析 |
Sexton, R. C. |
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N/A |
Bayesian nonparametric analysis of residence times for protein-lipid interactions in Molecular Dynamics simulations |