| DAF-16/Foxo通过系统性小RNA途径抑制prg-1 piRNA突变体的跨代不育 |
Simon, M. |
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N/A |
DAF-16/Foxo suppresses the transgenerational sterility of prg-1 piRNA mutants via a systemic small RNA pathway |
| 当没有答案比错误的答案更好时：关于批次效应的因果视角 |
Bridgeford, E. W. |
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N/A |
When no answer is better than a wrong answer: a causal perspective on batch effects |
| 为什么棕色的幽灵在夜晚鸣叫 |
Oboti, L. |
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N/A |
Why the brown ghost chirps at night |
| 黄素二铁蛋白通过依赖pH值的方式与类囊体膜结合，以进行由铁氧还蛋白-1驱动的O2光还原反应。 |
Nikkanen, L. |
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N/A |
Flavodiiron proteins associate pH-dependently with the thylakoid membrane for ferrdoxin-1 powered O2 photoreduction |
| 由于不适当继承的组蛋白甲基化导致的异位转录可能会干扰终末分化细胞的正在进行的功能。 |
Rodriguez, J. D. |
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N/A |
Ectopic transcription due to inappropriately inherited histone methylation may interfere with the ongoing function of terminally differentiated cells |
| 在不同啮齿动物杂交中，不同的复杂调控表型是导致杂交雄性不育的潜在原因。 |
Hunnicutt, K. E. |
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N/A |
Different complex regulatory phenotypes underlie hybrid male sterility in divergent rodent crosses |
| 重新发现卵巢网：卵巢的分泌辅助结构 |
Anbarci, D. N. |
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N/A |
Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary |
| 使用基于聚类的排列检验来估计MEG/EEG起始时间：有多糟糕？ |
Rousselet, G. A. |
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N/A |
Using cluster-based permutation tests to estimate MEG/EEG onsets: how bad is it? |
| Celsr3突变小鼠中的刻板行为与纹状体D3多巴胺受体的改变有关。 |
Cadeddu, R. |
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N/A |
Tic-related behaviors in Celsr3 mutant mice are contributed by alterations of striatal D3 dopamine receptors |
| 低盐度会破坏糖海带（Saccharina latissima，褐藻门）的细菌群落。 |
Schenk, S. |
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N/A |
Low salinity destabilizes the bacterial community of sugar kelp, Saccharina latissima (Phaeophyceae) |
| 在感知决策过程中，猕猴大脑的大规模新皮层网络中分布式证据积累 |
Zou, L. |
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N/A |
Distributed evidence accumulation across macaque large-scale neocortical networks during perceptual decision making |
| Id 位点的共同祖先：染色体重排与多基因可能性 |
Sharma, A. |
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N/A |
Common Ancestry of the Id Locus: Chromosomal Rearrangement and Polygenic Possibilities |
| 控制斑马鱼内胚层形成和左右模式形成的重复SOX因子的功能分化分子基础 |
Johal, S. |
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N/A |
The molecular basis for functional divergence of duplicated SOX factors controlling endoderm formation and left-right patterning in zebrafish |
| 担子菌类真菌菌丝直径的瞬时变化 |
Mazheika, I. S. |
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N/A |
Instantaneous change in hyphal diameter in basidiomycete fungi |
| 探索基于OPM-MEG的多变量传递熵的有向连接模式 |
Pedersen, M. |
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N/A |
Exploring Directed Connectivity Patterns of OPM-MEG with Multivariate Transfer Entropy |
| 全基因组关联研究揭示了与杂交大鼠海洛因易感性相关的痛觉和阿片类药物消耗行为的多个基因位点 |
Kuhn, B. N. |
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N/A |
Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats |
| GDFold2：一个快速且可并行化的蛋白质折叠环境，具有自由定义的目标函数 |
Mi, T. |
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N/A |
GDFold2: a fast and parallelizable protein folding environment with freely defined objective functions |
| 轴突细胞器因AP-4复合体功能丧失而积聚，导致阿尔茨海默病小鼠模型中淀粉样斑块病理和胶质增生的加剧。 |
Orlowski, A. |
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N/A |
Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimers disease mouse model |
| 使用MIDAS v3和StrainPGC准确估计宏基因组数据中的种内微生物基因含量变异 |
Smith, B. J. |
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N/A |
Accurate estimation of intraspecific microbial gene content variation in metagenomic data with MIDAS v3 and StrainPGC |
| 急性髓系白血病线粒体通过水解ATP来抵抗化疗 |
Hagen, J. T. |
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N/A |
Acute myeloid leukemia mitochondria hydrolyze ATP to resist chemotherapy |
| 星形胶质细胞转谷氨酰胺酶2的药理学抑制作用有助于促进神经支持性星形胶质细胞反应表型的表达，这与组蛋白乙酰化水平升高有关。 |
Delgado, T. |
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N/A |
Pharmacological inhibition of astrocytic transglutaminase 2 facilitates the expression of a neurosupportive astrocyte reactive phenotype in association with increased histone acetylation |
| parafac4microbiome：使用平行因子分析对纵向微生物组数据进行探索性分析 |
van der Ploeg, G. R. |
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N/A |
parafac4microbiome: Exploratory analysis of longitudinal microbiome data using Parallel Factor Analysis |
| 利用铁羟基氧化铁增强的分层磁共振成像技术绘制灵长类大脑中的血管网络结构 |
Autio, J. A. |
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N/A |
Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI |
| 解析急性运动缺陷和由小脑输出丧失引起的适应性反应 |
Sinha, N. |
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N/A |
Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output |
| 一个用于系统性和可重复性研究结构-功能关系的连接组操作框架，通过模拟实现。 |
Pokorny, C. |
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N/A |
A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations |
| 从鼠标视觉皮层活动重建电影 |
Bauer, J. |
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N/A |
Movie reconstruction from mouse visual cortex activity |
| 海洋环节动物多室草苔虫的基因组资源 |
Mutemi, K. N. |
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N/A |
A genome resource for the marine annelid Platynereis dumerilii |
| 非自主性胰岛素信号传导可延缓秀丽隐杆线虫生殖系干细胞和祖细胞的有丝分裂进程。 |
Cheng, E. |
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N/A |
Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells |
| 计算建模揭示了纹状体亚区域特异性多巴胺动态的关键决定因素 |
Ejdrup, A. L. |
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N/A |
Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum |
| 在人类和恒河猴中，HIV-1的进化动力学与广泛中和抗体的产生 |
Shimagaki, K. S. |
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N/A |
Parallel HIV-1 evolutionary dynamics in humans and rhesus macaques who develop broadly neutralizing antibodies |
| 蛋白质-蛋白质相互作用对酪氨酸磷酸酶PTP1B的别构调控 |
Chartier, C. A. |
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N/A |
Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction |
| 韩国都湖组（中新世）中新发现的金枪鱼标本（属Auxis） |
Suh, D. |
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N/A |
A new tuna specimen (Genus Auxis) from the Duho Formation (Miocene) of South Korea |
| 在微流控芯片上利用人胚胎干细胞衍生的类器官模拟软骨内骨化初期的血管动力学 |
Kesharwani, A. |
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N/A |
Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid |
| 横断面的脑龄评估在预测未来脑部变化方面存在局限性。 |
Korbmacher, M. |
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N/A |
Cross-sectional brain age assessments are limited in predicting future brain change |
| 细胞衍生基质的纳米力学作为胶原蛋白VI相关先天性肌营养不良症的功能读数 |
White, T. |
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N/A |
Nanomechanics of cell-derived matrices as a functional read-out in Collagen VI-related Congenital Muscular Dystrophies |
| Evolvoid：一种用于塑造最佳细胞结构的遗传算法 |
Mancini, P. |
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N/A |
Evolvoid: A genetic algorithm for shaping optimal cellular constructs |
| 成年大鼠的多重情境辨别：性别差异及厌恶记忆的时间依赖性泛化动态 |
Alves, F. N. L. |
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N/A |
Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory |
| LipiDetective - 一种用于识别串联质谱中分子脂质种类的深度学习模型 |
Wuerf, V. |
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N/A |
LipiDetective - a deep learning model for the identification of molecular lipid species in tandem mass spectra |
| 多巴胺和皮质iPSC衍生的神经元在不同的帕金森病突变中显示出溶酶体和线粒体功能障碍的差异：这对蛋白质沉积与选择性细胞丢失的影响 |
Chedid, J. |
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N/A |
Dopamine and cortical iPSC-derived neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction: implications for protein deposition versus selective cell loss |
| 在刚地弓形虫入侵过程中，宿主细胞质膜的穿孔需要棒状体胞吐作用。 |
Male, F. |
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N/A |
Perforation of the host cell plasma membrane during Toxoplasma gondii invasion requires rhoptry exocytosis |
| 代谢物营养图谱指南 - 揭示与疾病病因相互作用的代谢物营养图谱 |
Wuerf, V. |
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N/A |
MeNu GUIDE - a metabolite nutrition graph to uncover interactions with disease etiology |
| 一种跨动物和环境的普遍海马记忆编码 |
Wirtshafter, H. S. |
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N/A |
A universal hippocampal memory code across animals and environments |
| 智能分布式数据工厂：面向主动学习驱动分子数据采集的志愿者计算平台 |
Ghukasyan, T. |
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N/A |
Smart Distributed Data Factory: Volunteer Computing Platform for Active Learning-Driven Molecular Data Acquisition |
| 洗牌：扩展合成生物学工具箱以适应类似洗牌重组系统 |
Katalinic, J. |
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N/A |
Do the shuffle: Expanding the synthetic biology toolkit for shufflon-like recombination systems |
| 使用多重竞争性等位基因特异性PCR（mxKASP）基因分型确定合子性 |
de Visser, M. C. |
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N/A |
Determining zygosity with multiplex Kompetitive Allele-Specific PCR (mxKASP) genotyping |
| 保守的基因内容和独特的系统发育历史特征了Triturus平衡致死系统背后的“bloopergene” |
de Visser, M. C. |
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N/A |
Conserved gene content and unique phylogenetic history characterize the 'bloopergene' underlying Triturus' balanced lethal system |
| NewtCap：一种高效的目标捕获方法，用于提升蝾螈科（真蝾螈和新蝾螈）基因组研究 |
de Visser, M. C. |
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N/A |
NewtCap: an efficient target capture approach to boost genomic studies in Salamandridae (True Salamanders and Newts) |
| PAV-spotter：利用信号互相关识别目标捕获数据中的存在/缺失变异 |
de Visser, M. C. |
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N/A |
PAV-spotter: using signal cross-correlations to identify Presence/Absence Variation in target capture data |
| 鲸鱼语言模型（WhaleLM）：利用机器学习在抹香鲸的声音和行为中寻找结构与信息 |
Sharma, P. |
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N/A |
WhaleLM: Finding Structure and Information in Sperm Whale Vocalizations and Behavior with Machine Learning |
| 基因组证据表明，Triturus蝾螈中的平衡致死系统起源于一次瞬间的物种形成事件。 |
France, J. M. |
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N/A |
Genomic evidence suggests the balanced lethal system in Triturus newts originated in an instantaneous speciation event. |
| 使用CSI-TME识别IDH突变型胶质瘤肿瘤微环境中预后细胞状态相互作用 |
Singh, A. |
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N/A |
Identifying Prognostic Cell State Interactions in the Tumor Microenvironment of IDH-Mutant Gliomas Using CSI-TME |
| 底物利用和交叉喂养协同作用决定微生物群对病原体入侵的抵抗力 |
Yang, X. |
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N/A |
Substrate utilization and cross-feeding synergistically determine microbiome resistance to pathogen invasion |
| BNT162b2 JN.1-和KP.2-适应型COVID-19疫苗的免疫学和生物物理特性 |
Chen, W. |
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N/A |
Immunologic and Biophysical Features of the BNT162b2 JN.1- and KP.2-Adapted COVID-19 Vaccines |
| 对两种稀有鲸类物种解剖学的贡献：沙漏海豚（Lagenorhynchus cruciger）与眼镜海豚（Phocoena dioptrica） |
Graic, J.-M. |
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N/A |
A Contribution To The Anatomy Of Two Rare Cetacean Species: The Hourglass Dolphin (Lagenorhynchus cruciger) And The Spectacled Porpoise (Phocoena dioptrica) |
| 通过泛基因组学鉴定和表征古菌假肽聚糖生物合成基因 |
Lupo, V. |
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N/A |
Identification and Characterization of Archaeal Pseudomurein Biosynthesis Genes through Pangenomics |
| 基于图像的低嵌合体体细胞移动元件插入检测的DNA测序编码 |
Tan, M. |
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N/A |
Image-based DNA Sequencing Encoding for Detecting Low-Mosaicism Somatic Mobile Element Insertions |
| 子宫内膜蜕膜化反应的停滞决定了流产的复发风险 |
Muter, J. |
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N/A |
Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage |
| ERP和神经振荡能否用于区分在生态学上有效的运动模型中熟练和不熟练玩家的表现？ |
Winstanley, M. |
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N/A |
Can ERPs and neural oscillations be used to differentiate skilled and unskilled player performance in an ecologically valid sporting model? |
| Tidyplots 赋予生命科学家通过简单代码实现数据可视化的能力。 |
Engler, J. B. |
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N/A |
Tidyplots empowers life scientists with easy code-based data visualization |
| 血管转录因子TMO5调控PIN1极性及器官发生：在芽分生组织中作为MONOPTEROS的下游因子 |
Kareem, A. |
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N/A |
Vascular Transcription Factor TMO5 Regulates PIN1 Polarity andOrganogenesis Downstream of MONOPTEROS in the Shoot Meristem |
| 纠缠适应性景观通过外适应促进基因调控的进化 |
Westmann, C. A. |
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N/A |
Entangled adaptive landscapes facilitate the evolution of gene regulation by exaptation |
| 纠缠适应性景观通过外适应促进基因调控的进化 |
Westmann, C. A. |
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N/A |
Entangled adaptive landscapes facilitate the evolution of gene regulation by exaptation |
| 海马、纹状体和眶额皮质对时间信息的同步处理 |
Shimbo, A. |
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N/A |
Synchronous processing of temporal information across the hippocampus, striatum, and orbitofrontal cortex |
| 依赖于颗粒细胞的处理对于运动学习至关重要，但对于许多依赖小脑的行为来说却是可有可无的。 |
Lee, J.-H. |
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N/A |
Processing reliant on granule cells is essential for motor learning but dispensable for many cerebellar-dependent behaviors |
| 单细胞转录组学揭示埃及伊蚊中肠和脂肪体在吸血后的表达图谱 |
Vial, T. |
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N/A |
Single-cell transcriptional landscapes of Aedes aegypti midgut and fat body after a bloodmeal |
| 对比增强微型CT成像揭示了胎儿女性盆底解剖细节 |
Aaldijk, D. |
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N/A |
Contrast-Enhanced Micro-CT Imaging of a Foetal Female Pelvic Floor Reveals Anatomical Details |
| 长读RNA测序揭示了源自人类皮层神经元的转录本特异性调控 |
Xu, J. |
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N/A |
Long-Read RNA-sequencing reveals transcript-specific regulation in human-derived cortical neurons |
| 不同结合模式下的跨峰交联提示SARS-CoV-2抗体中和的补充机制 |
Nan, X. |
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N/A |
Distinct Binding Modes of Inter-Spike Cross-Linking Suggest a Supplementary Mechanism for SARS-CoV-2 Antibody Neutralization |
| ADP-MoA：一种用于筛选抗生素活性及其在铜绿假单胞菌中作用机制的平台 |
Valencia Morante, E. Y. |
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N/A |
ADP-MoA: a platform for screening antibiotic activity and their mechanism of action in Pseudomonas aeruginosa |
| 内质网对脂质代谢的感知驱动了PRA家族依赖的COPII囊泡运输调控 |
Nakazato, M. |
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N/A |
ER sensing of lipid metabolism drives PRA family-dependent regulation of COPII vesicle transport |
| 在秀丽隐杆线虫中进行的fat-2(wa17)抑制因子筛选揭示了适应多不饱和脂肪酸缺乏的遗传机制 |
Kaper, D. |
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N/A |
A fat-2(wa17) suppressor screen in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency |
| 健康人群的综合多组学分析 |
Visser, C. |
PDF |
N/A |
Comprehensive multi-omics profiling of a healthy human cohort |
| 极化剂AsymPolPOK在完整和裂解的哺乳动物细胞中的稳定性 |
Lacasga, D. |
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N/A |
Stability of the polarization agent AsymPolPOK in intact and lysed mammalian cells |
| 线粒体VDAC2的构象可塑性控制其与细胞质蛋白相互作用的动态过程 |
Rosencrans, W. M. |
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N/A |
Conformational plasticity of mitochondrial VDAC2 controls the kinetics of its interaction with cytosolic proteins |
| 五聚体尾管蛋白在SPR噬菌体中的组装结构 |
Zhu, H. |
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N/A |
Architecture of a pentameric assembly of the tail tube protein in SPR phages |
| 用于预测蛋白质pKa值和离子化状态的KaMLs：树结构是否足够？ |
Shen, M. |
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N/A |
KaMLs for Predicting Protein pKa Values andIonization States: Are Trees All You Need? |
| 成像活鼠、死鼠以及处于应激状态的植物的超微弱光子发射 |
SALARI, V. |
PDF |
N/A |
Imaging Ultraweak Photon Emission from Living and Dead Mice and from Plants under Stress |
| 基于细胞位置的多细胞系统中细胞力学特征评估 |
Koyama, H. |
PDF |
N/A |
Cell position-based evaluation of mechanical features of cells in multicellular systems |
| FRET和生物膜干涉技术揭示的NAD+核开关配体结合特性 |
Conoan Nieves, N. E. |
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N/A |
Ligand binding characteristics of an NAD+ riboswitch revealed by FRET and biolayer interferometry |
| Notch信号通路中二价异源三聚体结合的热力学 |
Cook, C. |
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N/A |
Thermodynamics of Bivalent Heterotrimer Association in the Notch Signaling Pathway |
| 泛紧密连接蛋白结合分子调节细胞旁屏障的生物物理基础 |
Ogbu, C. P. |
PDF |
N/A |
Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule |
| 通过液体振荡使转甲状腺素蛋白聚集 |
Ritsch, I. |
PDF |
N/A |
Aggregation of Transthyretin by Fluid Agitation |
| 人类和小鼠胰岛素中的一种翻译后半胱氨酸到丝氨酸的转化，产生了一种糖尿病相关的新表位。 |
Srivastava, N. |
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N/A |
A post-translational cysteine-to-serine conversion in human and mouse insulin generates a diabetogenic neoepitope |
| 人类活动而非环境因素是台湾地区斯克里普斯孢菌和洛门托孢菌分布的主要驱动力。 |
Wu, H.-M. |
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N/A |
Human activity, not environmental factors, drives Scedosporium and Lomentospora distribution in Taiwan |
| MAGE：异常基因表达的蒙特卡罗方法 |
Beltran, M. |
PDF |
N/A |
MAGE: Monte Carlo method for Aberrant Gene Expression |
| 使用少样本学习准确预测体细胞系和合子中CRISPR编辑结果 |
Zheng, W. |
PDF |
N/A |
Accurate prediction of CRISPR editing outcomes in somatic cell lines and zygote with few-shot learning |
| MOSAIC：微生物组研究分析整合与校正的管道 |
Fu, C. |
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N/A |
MOSAIC: A Pipeline for MicrobiOme Studies Analytical Integration and Correction |
| 人类着丝粒和近着丝粒区域中的类昆虫痘病毒长DNA序列 |
Hondo, E. |
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N/A |
Entomopoxvirus-like long DNA sequences in human centromeric and peri-centromeric regions |
| 通过计算机模拟识别针对四种感染性不动杆菌的新型共同药物靶点 |
Rahman, S. |
PDF |
N/A |
In silico Identification of Novel Common Drug Targets Against Four Infectious Acinetobacter Species |
| 结直肠癌III期单细胞空间图谱 |
Su, A. |
PDF |
N/A |
The single-cell spatial landscape of stage III colorectal cancers |
| 综合蛋白质组-基因组分析揭示了HER2阳性乳腺癌中拉帕替尼耐药的关键生物标志物 |
Steggall, J. |
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N/A |
Integrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer |
| 多巴胺D2受体激动剂可抑制神经内分泌肿瘤血管生成，从而抑制化疗耐药的小细胞肺癌进展 |
Alam, S. K. |
PDF |
N/A |
Dopamine D2 receptor agonists abrogate neuroendocrine tumour angiogenesis to inhibit chemotherapy-refractory small cell lung cancer progression |
| 视黄醇浸渍的纳米颗粒通过在小鼠体内对软骨内骨化的位点特异性调节，实现了对骨骼生长的控制。 |
Matsuoka, M. |
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N/A |
Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice |
| 活体木质部细胞编码大量负责维管汁液肽的保守基因家族 |
Lu, M. R. |
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N/A |
Living xylem cells encode a large number of conserved gene families responsible for vascular sap peptides |
| 偏移质量载体蛋白质组提高多重单细胞蛋白质组学定量 |
Cheung, T. |
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N/A |
Offset mass carrier proteome improves quantification of multiplexed single cell proteomics |
| 通过DBiTplus技术在同一组织切片上整合基于成像和基于测序的空间组学图谱 |
Enninful, A. |
PDF |
N/A |
Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus |
| iPAR：一种在风险人群未知情况下，用于建模和推断疾病传播信息的框架 |
Catterall, S. |
PDF |
N/A |
iPAR: A framework for modelling and inferring information about disease spread when the populations at risk are unknown |
| 白芷及其根际微生物对空心莲子草处理的生态响应 |
Huang, Y. |
PDF |
N/A |
Ecological response of Angelica dahurica and its rhizosphere microorganisms to treatments of Alternanthera philoxeroides |
| 描述指猴（Daubentonia madagascariensis）中新种系突变的速率和模式 |
Versoza, C. J. |
PDF |
N/A |
Characterizing the rates and patterns of de novo germline mutations in the aye-aye (Daubentonia madagascariensis) |
| 指猴（Daubentonia madagascariensis）的结构变异景观 |
Versoza, C. J. |
PDF |
N/A |
The landscape of structural variation in aye-ayes (Daubentonia madagascariensis) |
| 基于谱系的指猴（Daubentonia madagascariensis）交叉与非交叉图谱 |
Versoza, C. J. |
PDF |
N/A |
A pedigree-based map of crossovers and non-crossovers in aye-ayes (Daubentonia madagascariensis) |
| 疾病相关调控DNA变异与表皮稳态转录因子 |
Porter, D. F. |
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N/A |
Disease-Linked Regulatory DNA Variants and Homeostatic Transcription Factors in Epidermis |
| 研究管理决策在野生火鸡分布范围内亚种杂交中的作用 |
Beckman, A. K. |
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N/A |
Investigating the Role of Management Decisions in Subspecies Hybridization Across the Wild Turkey's Range |
| 烟酰胺腺嘌呤二核苷酸、三磷酸腺苷及氧化剂诱导的甘油醛-3-磷酸脱氢酶高阶构象变化的分析 |
Suzuki, H. |
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N/A |
Analysis of the high-order conformational changes in glyceraldehyde-3-phosphate dehydrogenase induced by nicotinamide adenine dinucleotide, adenosine triphosphate, and oxidants |
| 多样化的膜结合酰基转移酶的结构统一揭示了一种保守的折叠结构，这种结构定义了跨膜酰基转移酶（Transmembrane Acyl Transferase, TmAT）超家族。 |
Kinniment-Williams, B. E. |
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N/A |
Structural unification of diverse membrane-boundacyltransferases reveals a conserved fold that defines the Transmembrane Acyl Transferase (TmAT) superfamily |
| 超声组织消融术和人类多能干细胞衍生的肝球植入术作为先天性代谢性肝病潜在治疗手段的安全性和有效性：在免疫健全的啮齿动物模型中的评估。 |
Rashidi, H. |
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N/A |
The safety and efficacy of Ultrasound Histotripsy and human pluripotent stem cell-derived hepatic spheroid implantation as a potential therapy for treatment of congenital metabolic liver disease: assessment in an immunocompetent rodent model. |
| 人体器官尺度上的物理玻璃化和纳米升温技术，以实现冷冻保存 |
Gangwar, L. |
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N/A |
Physical vitrification and nanowarming at human organ scale to enable cryopreservation |
| 从人类肠道类器官实时测量血清素动态 |
Bohl, B. |
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N/A |
Measurement of Real Time Serotonin Dynamics from Human Derived Gut Organoids |
| 儿童唾液DNA甲基化分析中细胞类型异质性的考量：参考面板比较与按估算细胞类型比例的分层 |
Chan, M. H.-M. |
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N/A |
Considerations for Cell Type Heterogeneity in Pediatric Salivary DNA Methylation Analyses: Comparison of Reference Panels & Stratification by Estimated Cell TypeProportion |
| 通过序列嵌入进行RNA-蛋白质相互作用分类 |
Matus, D. |
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N/A |
RNA-Protein Interaction Classification via Sequence Embeddings |
| 基于类固醇代谢途径的新型深度神经网络模型的生物年龄预测 |
Wang, Q. |
PDF |
N/A |
Biological age prediction using a novel DNN model based on steroid metabolic pathways |
| NOODAI：面向网络的多组学数据分析与整合管道的网络服务器 |
Totu, T. |
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N/A |
NOODAI: A webserver for network-oriented multi-omics data analysis and integration pipeline |
| 苯并尼达唑抗性克氏锥虫克隆的转录组分析揭示了硝基还原酶I非依赖性抗性机制 |
Mejia-Jaramillo, A. M. |
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N/A |
Transcriptomic analysis of benznidazole-resistant Trypanosoma cruzi clone reveals nitroreductase I-independent resistance mechanisms |
| 迁移学习和DNA语言模型提升转录因子结合预测 |
Aksu, E. D. |
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N/A |
Transfer learning and DNA language models enhance transcription factor binding predictions |
| 系统识别和表征病毒长链非编码RNA（lncRNA）表明，病毒lncRNA广泛模拟宿主lncRNA的结构。 |
Fu, P. |
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N/A |
Systematic identification and characterization of virus lncRNAs suggests extensive structural mimicry of host lncRNAs |
| 一个稳健的工作流程用于基准测试多组学数据的反卷积 |
Amblard, E. |
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N/A |
A robust workflow to benchmark deconvolution of multi-omic data |
| 通过双聚类分析揭示英国生物银行中的隐性基因-性状模式 |
Pividori, M. |
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N/A |
Uncovering hidden gene-trait patterns through biclustering analysis of the UK Biobank |
| 将结构表示提取到蛋白质序列模型中 |
Ouyang-Zhang, J. |
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N/A |
Distilling structural representations into protein sequence models |
| 针对急性髓系白血病干细胞治疗后复发中的IL-1/IRAK1/4信号传导 |
Ho, T.-C. |
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N/A |
Targeting IL-1/IRAK1/4 signaling in Acute Myeloid Leukemia Stem Cells Following Treatment and Relapse |
| 健康B细胞：CAR-T细胞免疫疗法的盟友还是对手？ |
Paixao, E. A. |
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N/A |
Healthy B cells: allies or adversaries of CAR-T cell immunotherapy? |
| 骨髓微环境特征与HMA耐药MDS患者接受吉达西他滨和阿替利珠单抗治疗后的患者生存相关 |
Jang, H. J. |
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N/A |
Bone marrow microenvironment signatures associate with patient survival after guadecitabine and atezolizumab therapy in HMA-resistant MDS |
| HHLA2介导的配体非依赖性c-Met激活驱动肝细胞癌并预测c-MET抑制剂疗效 |
huang, x. |
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N/A |
Ligand-independent c-Met activation by HHLA2 drives hepatocellular carcinoma and predicts c-MET inhibitor efficacy |
| 单细胞视频追踪以识别聚集行为 |
Korsnes, M. S. |
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N/A |
Video tracking of single cells to identify clustering behaviour |
| 晚更新世巴西东南部灰侏儒鹿摄食策略的千年尺度稳定性。 |
Hubbe, A. |
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N/A |
Late Quaternary millennial-scale stability of the feeding strategy of the gray brocket deer in Southeastern Brazil. |
| 绿合成、表征及以Talinum triangulare叶提取物为媒介的Ag-MgO纳米复合材料的潜在抗菌研究 |
Fonye Nyuyfoni, G. |
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N/A |
Green synthesis, characterization, and potential antimicrobial studies of Ag-MgO nanocomposites mediated from Talinum triangulare leaf extract |
| 高强度间歇运动对心肺和神经肌肉反应的性别差异 |
Wilson, H. |
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N/A |
Sex differences in the cardiopulmonary and neuromuscular response to high-intensity interval exercise |
| 质外体代谢组学揭示了植物-病原体相互作用受氮素供应的调控 |
Jeridi, R. |
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N/A |
Apoplast metabolomics reveals that plant-pathogen crosstalk is modulated by nitrogen supply |
| 海生被子植物大叶藻（Zostera marina）中，成花素和抗成花素基因的表达与生殖状态相关。 |
Nolan, C. T. |
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N/A |
Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm, Zostera marina |
| 预测化合物在Reactome知识库中的路径参与情况 |
Huckvale, E. D. |
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N/A |
Predicting the Pathway Involvement of Compounds Annotated in the Reactome Knowledgebase |
| 密度依赖性如何调节害虫的种群控制：遗传生物防治的视角 |
Butler, C. D. |
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N/A |
How population control of pests is modulated by density dependence: The perspective of genetic biocontrol |
| 里海海平面快速下降需要动态时空保护规划，以保持生物多样性保护措施的相关性。 |
Court, R. |
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N/A |
Rapid Caspian sea level decline requires dynamic spatio-temporal conservation planning to keep biodiversity protection measures relevant |
| 从高质量的全基因组群体水平数据推断指猴（Daubentonia madagascariensis）的种群历史 |
Terbot, J. W. |
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N/A |
Inferring the demographic history of aye-ayes (Daubentonia madagascariensis) from high-quality, whole-genome, population-level data |
| 暗翅蕈蚊Lycoriella ingenua的初级性别比例的母系遗传 |
Shlyakonova, M. |
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N/A |
Maternal inheritance of primary sex ratios in the dark-winged fungus gnat Lycoriella ingenua |
| 利用一个拟合良好的进化基准模型，对指猴（Daubentonia madagascariensis）进行全基因组扫描，以寻找近期正选择和平衡选择的证据。 |
Soni, V. |
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N/A |
A whole-genome scan for evidence of recent positive and balancing selection in aye-ayes (Daubentonia madagascariensis) utilizing a well-fit evolutionary baseline model |
| 冬小麦产量及产量表型可塑性的遗传调控 |
Giordano, N. |
PDF |
N/A |
Genetic modulation of yield and phenotypic plasticity of yield in winter wheat |
| 秀丽隐杆线虫中RNA结合与调控蛋白的全景图 |
Laver, J. D. |
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N/A |
A global view of the RNA-binding and regulatory protein landscape in Caenorhabditis elegans |
| 基于无细胞RNA中可转座元件特征的子痫前期早期预测 |
Patel, M. |
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N/A |
Early Prediction of Preeclampsia Based on Transposable Elements signature in cell-free RNA |
| 巨型鞭蠹（Mastigoproctus giganteus）染色体水平基因组显示出前志留纪全基因组复制的特征。 |
Kulkarni, S. |
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N/A |
A chromosome-level genome of the giant vinegaroon Mastigoproctus giganteus exhibits the signature of pre-Silurian whole genome duplication |
| 通过细胞表面和病毒包膜工程的配对增强了对哺乳动物细胞的慢病毒基因递送 |
Tannir, R. |
PDF |
N/A |
Enhanced lentiviral gene delivery to mammalian cells via paired cell surface and viral envelope engineering |
| 胶质母细胞瘤驱动蛋白酶非依赖性的微胶质细胞外基质侵袭 |
Chang, C.-W. |
PDF |
N/A |
Glioblastoma Drives Protease-Independent Extracellular Matrix Invasion of Microglia |
| 从单细胞数据推断细胞类型特异性共表达基因 |
Shan, X. |
PDF |
N/A |
Inferring Cell-Type-Specific Co-Expressed Genes from Single Cell Data |
| 一种适用于深度自上而下蛋白质组学的全窗口数据独立采集方法 |
Sun, C. |
PDF |
N/A |
A Full Window Data Independent Acquisition Method for DeeperTop-down Proteomics |
| CelLink：整合具有少量关联特征和不平衡细胞群体的单细胞多组学数据 |
Luo, X. |
PDF |
N/A |
CelLink: Integrate single-cell multi-omics data with few linked features and imbalanced cell populations |
| ScisTree2：一种改进的大规模推断细胞谱系树和从噪声单细胞数据进行基因型调用的方法 |
Zhang, H. |
PDF |
N/A |
ScisTree2: An Improved Method for Large-scale Inference of Cell Lineage Trees and Genotype Calling from Noisy Single Cell Data |
| 来自海洋水柱中全海洋深度原核生物的小蛋白 |
Wang, Y. |
PDF |
N/A |
Small proteins from prokaryotes in marine water column at full ocean depth |
| 慢性间歇性乙醇通过内源性大麻素非依赖性机制在小鼠中产生痛觉 |
Miliano, C. |
PDF |
N/A |
Chronic intermittent ethanol produces nociception through endocannabinoid-independent mechanisms in mice |
| 使用氯胺酮作为潜在抗抑郁剂后对两性青春期大鼠的安全性担忧 |
Jornet-Plaza, J. |
PDF |
N/A |
Safety concerns following the use of ketamine as a potential antidepressant for adolescent rats of both sexes |
| 铜绿假单胞菌吡咯喹啉醌和1-羟基吩嗪对人类鼻上皮细胞内钙离子、线粒体功能及存活率的影响 |
Thompson, J. C. |
PDF |
N/A |
Effects of Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on intracellular calcium, mitochondrial function, and viability in human nasal epithelial cells |
| 长期存在于肝脏中的记忆T细胞，其特异性偏向于丰富的子孢子抗原，通过辐射减毒子孢子疫苗驱动疟疾保护作用。 |
de Menezes, M. N. |
PDF |
N/A |
Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination |
| 长期存活的肝驻留记忆T细胞，其特异性偏向于丰富的子孢子抗原，通过辐射减毒子孢子疫苗驱动疟疾保护作用。 |
de Menezes, M. N. |
PDF |
N/A |
Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination |
| 鉴定和表征具有高亲和力和强效抗白血病活性的血管活性肠肽受体拮抗剂 |
Wang, Y. |
PDF |
N/A |
Identification and characterization of vasoactive intestinal peptide receptor antagonists with high-affinity and potent anti-leukemia activity |
| 理解城市食品生产中的授粉：公民科学项目设计中数据验证和参与者反馈的重要性 |
Nicholls, E. |
PDF |
N/A |
Understanding pollination in urban food production: the importance of data validation and participant feedback for citizen science project design |
| 在气候变化背景下人类改造景观中的生态同步性 |
Song, Y. |
PDF |
N/A |
Ecological synchrony in human-modified landscapes under a changing climate |
| 环境与个体变异对小型实验种群灭绝时间模式的影响。 |
Bakker, S. |
PDF |
N/A |
Effects of environmental and individual variation on time patterns of extinction in small experimental populations. |
| 评估密西西比湾（美国）搁浅的大西洋宽吻海豚（Tursiops truncatus）的遗传多样性 |
Arick, M. |
PDF |
N/A |
Assessment of the Genetic Diversity of Atlantic Bottlenose Dolphin (Tursiops truncatus) Strandings in the Mississippi Sound (USA) |
| 结合便携式样品制备和逆转录环介导等温扩增的柑橘衰退病毒快速比色检测 |
Liu, C.-W. |
PDF |
N/A |
Rapid colorimetric detection of citrus tristeza virus combining portable sample preparation and reverse transcription-loop mediated isothermal amplification |
| 扩张型心肌病中TITIN变异的含义：整合全外显子测序与分子动力学模拟研究 |
Mukhopadhyay, A. |
PDF |
N/A |
Implication of TITIN Variations in Dilated Cardiomyopathy: Integrating Whole Exome Sequencing With Molecular Dynamics Simulation Study |
| 综合多组学分析揭示巨噬细胞如何驱动乳腺癌中的免疫抑制并影响临床结果 |
Azimzade, Y. |
PDF |
N/A |
Integrated multiomics analysis unveils how macrophages drive immune suppression in breast tumors and affect clinical outcomes |
| scLong：用于捕捉单细胞转录组学中长程基因背景的十亿参数基础模型 |
Bai, D. |
PDF |
N/A |
scLong: A Billion-Parameter Foundation Model for Capturing Long-Range Gene Context in Single-Cell Transcriptomics |
| 产前砷暴露与胎儿肝脏、心脏、肺和胎盘中基因表达的关系 |
Rychlik, K. A. |
PDF |
N/A |
Prenatal Arsenic Exposure and Gene Expression in Fetal Liver, Heart, Lung, and Placenta |
| 芹菜油（Apium graveolens）-肉豆蔻酸基微乳体系的体外抗癌、抗炎和抗氧化活性：表征与生物医学应用 |
Govindaswamy, B. |
PDF |
N/A |
In vitro anti cancer, anti inflammatory and anti oxidant activity of Celery oil (Apium graveolens)-Myristic acid based microemulsion system: Characterization and Biomedical application |
| 多扎格列汀和肠促胰岛素在胰岛素分泌中的性别依赖性加性效应：一种新型GCK-MODY小鼠模型的研究 |
Salazar, S. |
PDF |
N/A |
Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of GCK-MODY |
| 预印本与期刊文章：COVID-19研究中的引用影响 |
Tsunoda, H. |
PDF |
N/A |
Preprints vs. Journal Articles: Citation Impact in COVID-19 Research |
| 能够选择性靶向RAS驱动型癌症的合成基因电路 |
Senn, G. V. |
PDF |
N/A |
Synthetic gene circuits that selectively target RAS-driven cancers |
| 多组学分析揭示了来自海鞘Botryllus schlosseri的微生物衍生代谢物在金属相互作用中的重要作用 |
Matus, D. G. G. |
PDF |
N/A |
Multi-omics Analysis Reveals Important Role for Microbial-derived Metabolites from Botryllus schlosseri in Metal Interactions |
| 植物高度动态杂种优势的代谢途径在水稻中是稳健的生物标志物。 |
Dan, Z. |
PDF |
N/A |
The metabolic pathways underlying dynamic heterosis for plant height are robust biomarkers in rice |
| 夜行性土豚（Orycteropus afer，管齿目）的眼部特征与视网膜感光细胞 |
Peichl, L. |
PDF |
N/A |
Eye features and retinal photoreceptors of the nocturnal aardvark (Orycteropus afer, Tubulidentata) |
| 老化大脑的自由水消除径向测量法 |
Chang, K. H. |
PDF |
N/A |
Free water elimination tractometry for aging brains |
| 超越字母：最优传输作为亚字母正字法处理的模型 |
Taylor, J. E. |
PDF |
N/A |
Beyond Letters: Optimal Transport as a Model for Sub-Letter Orthographic Processing |
| 皮层内微刺激导致脑血流与神经活动空间错配 |
Yonza, A. K. I. |
PDF |
N/A |
Spatially mismatched cerebral blood flow and neuronal activity by intracortical microstimulation |
| 个性化fMRI引导rTMS目标的分水岭算法图形用户界面 |
Feng, Z.-j. |
PDF |
N/A |
A Watershed Algorithm GUI for Personalized fMRI-guided rTMS Target |
| 系统性自身免疫病中常见罕见和新奇的RELA变异 |
Downes, M. B. |
PDF |
N/A |
Rare and novel RELA variants are common in systemic autoimmunity |
| 在两匹患有急性呼吸综合征的马的淋巴结和肺组织中发现的昆虫特异性阿尔法介体病毒1（Mesoniviridae科） |
Jurisic, L. |
PDF |
N/A |
Insect-specific Alphamesonivirus-1 (Mesoniviridae) in lymph node and lung tissues from two horses with acute respiratory syndrome |
| 蛇纹岩的微生物生态学 |
Colman, D. R. |
PDF |
N/A |
The Microbial Ecology of Serpentinites |
| 圈养繁殖的墨西哥钝口螈在恢复和人工湿地中的运动生态学：两栖动物再引入和迁徙的保育启示 |
Ramos, A. G. |
PDF |
N/A |
Movement ecology of captive-bred axolotls in restored and artificial wetlands: conservation insights for amphibian reintroductions and translocations |
| 野生动物贸易的过度监管 |
Challender, D. |
PDF |
N/A |
Disproportionate regulation of wildlife trade |
| 大规模遥感数据显示，德国的树木死亡率似乎高于之前的预期。 |
Schiefer, F. |
PDF |
N/A |
Large-scale remote sensing reveals that tree mortality in Germany appears to be greater than previously expected |
| 与火灾后的模式相比，在皆伐和抢救性采伐后的土壤群落具有不同的早期演替动态。 |
Porter, T. M. |
PDF |
N/A |
Soil communities following clearcut and salvage harvest have different early successional dynamics compared with post-wildfire patterns |
| 多源摄影证据评估亚洲象的走廊使用情况、作物侵袭行为及身体伤害 |
NR, A. |
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N/A |
Multi-source photographic evidence to assess corridor use, crop-raiding behaviour, and body injuries in Asian elephants |
| 大量开花和花期不同步是西高止山脉一个季节性草本植物群落的特征。 |
Shrotri, S. |
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N/A |
Mass flowering and flowering asynchrony characterise a seasonal herbaceous community in the Western Ghats |
| 通过扩展的DEST 2.0基因组资源，在结构化种群的D. melanogaster中全球适应的足迹 |
Nunez, J. C. B. |
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N/A |
Footprints of worldwide adaptation in structured populations of D. melanogaster through the expanded DEST 2.0 genomic resource |
| 被子植物中葡萄性别决定区域的演化历史及葡萄科中雌雄异株的出现 |
Massonnet, M. |
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N/A |
Evolutionary history of the grape sex-determining region in angiosperms and emergence of dioecy in Vitaceae |
| mRNP组成的各种改变会引发有害R-loop的增加 |
Merida-Cerro, J. A. |
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N/A |
Different alterations in mRNP composition trigger an increase in harmful R-loops |
| 大鼠单核多器官染色质可及性图谱 |
Li, R. |
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N/A |
Single-nucleus multiple-organ chromatin accessibility mapping in the rat |
| 蜜蜂嗅觉行为的机器学习在野外自由飞行的蜜蜂中识别出排斥性气味物质 |
Kowalewski, J. |
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N/A |
Machine learning of honey bee olfactory behavior identifies repellent odorants in free flying bees in the field |
| 人类行走的能量消耗作为不平坦地形幅度的函数 |
Hosseini-Yazdi, S.-S. |
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N/A |
The energetic cost of human walking as a function of uneven terrain amplitude |
| 可编程蛋白质降解剂能够在体外和体内选择性敲低致病性β-连环蛋白亚群 |
Ye, T. |
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N/A |
Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo |
| 评估深度学习生成的三维分子的构象有效性和合理性 |
Fan, F. |
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N/A |
Assessing Conformation Validity and Rationality of Deep Learning-Generated 3D Molecules |
| 利用进化尺度建模的深度学习方法发现针对肺炎克雷伯菌的抗生素耐药药物 |
Jin, L. |
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N/A |
Deep Learning with Evolutionary Scale Modeling to discover Antibiotic-Resistance Drug against Klebsiella Pneumoniae |
| Diverse-Seq：一种用于无对齐选择和聚类生物序列的应用程序 |
Huttley, G. A. |
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N/A |
diverse-seq: an application for alignment-free selecting and clustering biological sequences |
| 通过局部治疗克服乳腺癌耐药性的多靶点天然配体及高效siRNA设计的计算机发现 |
Hashemi, S. M. J. |
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N/A |
In Silico Discovery of Multi-Target Natural Ligands and Efficient siRNA Design for Overcoming Drug Resistance in Breast Cancer via Local Therapy |
| ROSIE：从组织病理学图像生成多重免疫荧光染色的人工智能技术 |
Wu, E. |
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N/A |
ROSIE: AI generation of multiplex immunofluorescence staining from histopathology images |
| CYP2E1对肾脏的性别依赖性影响及4MP对顺铂诱导肾毒性的保护潜力 |
Akakpo, J. Y. |
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N/A |
Sex-dependent effects of CYP2E1 on the kidney and the protective potential of 4MP against cisplatin-induced nephrotoxicity |
| 根木质部面积通过土壤质地依赖的方式影响珍珠粟的耐旱性和蒸腾作用 |
Affortit, P. |
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N/A |
Root metaxylem area influences drought tolerance and transpiration in pearl millet in a soil texture dependent manner |
| 聚苯乙烯纳米塑料通过催化TDP43的过度磷酸化促进神经退行性变。 |
Winanto, W. |
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N/A |
Polystyrene nanoplastics promote neurodegeneration by catalyzing TDP43 hyperphosphorylation |
| 基底节颤抖症中丘脑、小脑和运动皮层之间的振荡耦合 |
Steina, A. |
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N/A |
Oscillatory coupling between thalamus, cerebellum and motor cortex in essential tremor |
| 以少胜多：基于模拟的推断使得在极短的采集时间内也能获得准确的扩散加权磁共振成像 |
Eggl, M. F. |
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N/A |
More with less: Simulation-based inference enables accurate diffusion-weighted MRI with minimal acquisition time |
| 持续的感觉运动转换增强了猕猴运动皮层神经动力学对扰动的鲁棒性 |
Cui, H. |
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N/A |
Continuous sensorimotor transformation enhances robustness of neural dynamics to perturbation in macaque motor cortex |
| 人类对基因减毒疟原虫的相关体液和细胞免疫 |
Colstrup, E. |
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N/A |
Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humans |
| 一种调节因子在莫拉氏菌科中同时调控DNA损伤应答与抗噬菌体防御网络 |
Song, S. |
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N/A |
A regulator controls both DNA damage response and anti-phage defense networks in Moraxellaceae |
| 卵母细胞中CDK12的缺失导致女性不孕 |
Jansova, D. |
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N/A |
Absence of CDK12 in oocyte leads to female infertility |
| SARS-CoV-2 BA.2.86变异株及其亚系在刺突蛋白中对赖氨酸的偏好增加，而对精氨酸的偏好减少。 |
Bozic, A. |
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N/A |
Increased preference for lysine over arginine in spike proteins of SARS-CoV-2 BA.2.86 variant and its sublineages |
| Src抑制对人类膀胱癌临床前模型中转移决定因素的异质性效应 |
Aragaki, K. |
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N/A |
Heterogeneous Effects of Src Inhibition on Determinants of Metastasis in Preclinical Models of Human Bladder Cancer |
| ELOVL6作为治疗靶点：破坏c-MYC驱动的脂质代谢以增强胰腺癌化疗 |
Garcia Garcia, A. |
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N/A |
ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic Cancer |
| 活细胞磁性显微操作回收内体揭示其对促进侵袭性迁移的肌动蛋白基突起的直接影响 |
Gemperle, J. |
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N/A |
Live-cell magnetic micromanipulation of recycling endosomes reveals their direct effect on actin-based protrusions to promote invasive migration |
| 心脏修复中纤维化生态位的时空动力学 |
Grün, D. |
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N/A |
Spatio-temporal dynamics of the fibrotic niche in cardiac repair |
| 家蚕茧的抗刺穿性能 |
Rehman, A. U. |
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N/A |
The stab resistance of Bombyx mori silk cocoons |
| 新发现的脊椎动物早期抗病毒感染中IgM的保守作用 |
Kong, W. |
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N/A |
Newly discovered and conserved role of IgM against viral infection in an early vertebrate |
| 胆固醇代谢与结核分枝杆菌内部的钾离子稳态之间存在内在关联。 |
Chen, Y. |
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N/A |
Cholesterol metabolism and intrabacterial potassium homeostasis are intrinsically related in Mycobacterium tuberculosis |
| 用于研究COVID感染后遗症的适应小鼠的SARS-CoV-2模型 |
Zhao, Z. |
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N/A |
A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection |
| 模拟近海油田环境：双厌氧生物膜反应器对微生物诱导腐蚀的见解 |
Jones, L. M. |
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N/A |
Simulating Offshore Oilfield Conditions: Insights into Microbiologically Influenced Corrosion from a Dual Anaerobic Biofilm Reactor |
| 在细胞间传播过程中，志贺氏菌（Shigella flexneri）需要一个具有易位能力的孔道来逃逸双层膜液泡。 |
Raab, J. E. |
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N/A |
A translocation-competent pore is required for Shigella flexneri to escape from the double membrane vacuole during intercellular spread |
| 微管结合诱导了动力蛋白-1中一种类似于Mg-free的ADP预释放构象，这种构象不受其自抑制尾的影响。 |
Atherton, J. |
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N/A |
Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail |
| 食品级植物抗氧化剂配方抑制肌红蛋白氧化 |
Vergara-Stange, V. |
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N/A |
Inhibition of Myoglobin Oxidation by Food Grade Botanical Antioxidant Formulations |
| UniOP：一种利用基因间距离对高通量原核生物（元）基因组数据进行通用操纵子预测的方法 |
Su, H. |
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N/A |
UniOP: a universal operon prediction for high-throughput prokaryotic (meta-)genomic data using intergenic distance |
| AlphaBind，一种特定领域的模型，用于预测和优化抗体-抗原结合亲和力 |
Agarwal, A. A. |
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N/A |
AlphaBind, a Domain-Specific Model to Predict and Optimize Antibody-Antigen Binding Affinity |
| 使用条件最优传输在单细胞水平建模CAR响应 |
Driessen, A. |
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N/A |
Modeling CAR Response at the Single-Cell Level Using Conditional Optimal Transport |
| 从人诱导多能干细胞生成形态不同的星形胶质细胞亚型揭示了胶质形态、功能和反应性之间的联系 |
O'Toole, K. |
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N/A |
Generation of morphologically distinct astrocyte subtypes from human iPSCs reveals a link between glial shape, function and reactivity |
| 极光激酶A通过调节内源性S-腺苷甲硫氨酸代谢促进训练免疫 |
Li, M. |
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N/A |
Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism |
| 单分子成像技术在T细胞转录动力学、RNA定位及命运研究中的应用 |
Lattanzio, M. V. |
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N/A |
Single molecule imaging of transcription dynamics, RNA localization and fate in T cells |
| 比较基因组学揭示粘细菌碳水化合物降解潜力及其生态影响。 |
Saraf, N. |
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N/A |
Comparative genomic insight into the myxobacterial carbohydrate-degrading potential and their ecological impact. |
| 抗病毒抗性进化揭示了基孔肯雅病毒包膜糖蛋白之间短暂的跨域功能相互作用 |
Battini, L. |
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N/A |
Evolution of antiviral resistance captures a transient interdomain functional interaction between chikungunya virus envelope glycoproteins |
| 在半高通量分析中评估青蒿素治疗后恶性疟原虫的生长、抗性和恢复情况 |
Sievert, M. A. |
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N/A |
Measuring Growth, Resistance and Recovery after Artemisinin Treatment of Plasmodium falciparum in a semi-high-throughput Assay |
| 乙醇胺诱导的微隔室组装是具核梭杆菌毒力所必需的 |
Franklin, D. |
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N/A |
Ethanolamine-induced assembly of microcompartments is required for Fusobacterium nucleatum virulence |
| 解析关键分类单元：门多塔湖微生物网络内的相互作用及环境动态 |
Yang, Q. |
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N/A |
Unraveling Keystone Taxa: Interactions Within Microbial Networks and Environmental Dynamics in Lake Mendota |
| NLRP1 被棕榈酸激活，并在人类代谢功能障碍相关性脂肪性肝炎中被诱导。 |
Pinilla, M. |
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N/A |
NLRP1 is activated by palmitic acid and induced in human metabolic dysfunction-associated steatohepatitis |
| 在卵子发生和早期胚胎发生过程中对bicoid mRNA的调控影响蛋白质梯度的形成。 |
Athilingam, T. |
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N/A |
Regulation of bicoid mRNA throughout oogenesis and early embryogenesis impacts protein gradient formation |
| 毛里求斯果蝇中交叉分布的模式需要重新思考着丝粒对交叉的影响 |
Hawley, R. S. |
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N/A |
Patterns of crossover distribution in Drosophila mauritiana necessitate a re-thinking of the centromere effect on crossing over |
| U1 snRNP特异性蛋白U1C在snRNP生物发生中充当运动神经元生存（SMN）复合体的守门员 |
Ngu, D. M. |
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N/A |
U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP Biogenesis |
| 通过定制的CRISPR-Cas9碱基编辑器治疗体内严重的血管疾病 |
Alves, C. R. R. |
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N/A |
In vivo Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor |
| 负链RNA病毒中的转录梯度提示了一种共同的RNA转录机制 |
King, C. R. |
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N/A |
The Transcriptional Gradient in Negative-Strand RNA Viruses Suggests a Common RNA Transcription Mechanism |
| 升高的I型干扰素信号定义了ARF和p53突变肿瘤细胞的增殖优势 |
Mabry, A. |
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N/A |
Elevated type I interferon signaling defines the proliferative advantage of ARF and p53 mutant tumor cells |
| Elovl1抑制减少了肾上腺脑白质营养不良小鼠模型中的极长链脂肪酸。 |
Huang, J. |
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N/A |
Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy |
| MdMPK6/02G介导的MdWRKY70L磷酸化调控活性氧合成以调节苹果果实衰老 |
Wang, H. |
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N/A |
Phosphorylation of MdWRKY70L by MdMPK6/02G mediates reactive oxygen synthesis to regulate apple fruit senescence |
| 自然语言提示指导新型功能性蛋白质序列的设计 |
Praljak, N. |
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N/A |
Natural Language Prompts Guide the Design of Novel Functional Protein Sequences |
| 固定石蜡包埋活检的单细胞空间转录组学揭示了与结肠炎相关的细胞网络 |
Mennillo, E. |
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N/A |
Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks |
| 艰难梭菌的抗菌药物敏感性测试：一项针对三种不同培养基和三种治疗性抗菌药物的双中心研究 |
Freeman, J. |
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N/A |
Antimicrobial susceptibility testing of Clostridioides difficile: a dual-site study of three different media and three therapeutic antimicrobials |
| 构象变化、过剩面积及Piezo蛋白-膜纳米穹顶的弹性：来自粗粒化和原子模拟的研究 |
Dixit, S. |
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N/A |
Conformational changes, excess area, and elasticity of the Piezo protein-membrane nanodome from coarse-grained and atomistic simulations |
| 共享住宅庭院中的生物多样性潜力 |
Livne, H. |
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N/A |
Potential for Biodiversity in Shared Residential Yards |
| 适应性蛋白质协同进化保持端粒完整性 |
Futeran, H. |
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N/A |
Adaptive protein coevolution preserves telomere integrity |
| 全面评估AlphaFold-Multimer、AlphaFold3和ColabFold在预测蛋白质-肽复合物结构中的表现及评分函数 |
Manshour, N. |
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N/A |
Comprehensive Evaluation of AlphaFold-Multimer, AlphaFold3 and ColabFold, and Scoring Functions in Predicting Protein-Peptide Complex Structures |
| 在慢性病毒感染小鼠期间，凝血酶原可预防致命的T细胞依赖性贫血 |
Cantrell, R. |
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N/A |
Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice |
| 饥饿通过抑制纹状体尾部多巴胺信号来调节探索行为 |
Kamath, T. |
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N/A |
Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum |
| 扩展杏仁核促肾上腺皮质激素释放激素神经元调控草原田鼠（Microtus ochrogaster）在社会挫败后配对结合形成的性别二态性变化 |
Tickerhoof, M. C. |
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N/A |
Extended amygdala corticotropin-releasing hormone neurons regulate sexually dimorphic changes in pair bond formation following social defeat in prairie voles (Microtus ochrogaster) |
| 呼吸网络中的非对称神经调制有助于节律和模式的生成。 |
Dhingra, R. R. |
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N/A |
Asymmetric neuromodulation in the respiratory network contributes to rhythm and pattern generation |
| 来自CDKL5缺陷症患者来源的皮质兴奋性神经元在早期表现出过度兴奋性，而这种过度兴奋性在由Neurogenin2诱导的神经元中未被发现。 |
Glass, M. R. |
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N/A |
Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons |
| 对性别偏向选择反应的表达分歧 |
Grieshop, K. |
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N/A |
Expression divergence in response to sex-biased selection |
| 中性粒细胞胞外陷阱促进肿瘤对蒽环类药物的化学耐药性 |
Lin, C. |
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N/A |
Neutrophil extracellular traps promote tumor chemoresistance to anthracyclines |
| 线粒体相关内质网膜对胆固醇稳态的贡献 |
Montesinos, J. |
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N/A |
The contribution of mitochondria-associated ER membranes to cholesterol homeostasis |