| 药物抗性感染的机械时空模型 |
Lee, T. E. |
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N/A |
A mechanistic spatiotemporal model for drug resistant infections |
| 普通豆（Phaseolus vulgaris L.）对土壤干燥的全株蒸腾响应：水通道蛋白与转录因子 |
Cordoba-Novoa, H. A. |
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N/A |
Whole Plant Transpiration Responses of Common Bean (Phaseolus vulgaris L.) to Drying Soil: Water Channels and Transcription Factors |
| 为什么作物多模型研究中存在如此大的差异性？ |
Wallach, D. |
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N/A |
Why is there so much variability in crop multi-model studies? |
| 克隆进化介导了KMT2A重排白血病中的Menin抑制剂耐药性。 |
Mahdavi, L. |
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Clonal evolution mediates Menin-inhibitor resistance in KMT2A-rearranged leukemias. |
| 心脏转录增强子在再生过程中被重新利用，以激活一种抗增殖程序 |
Rao, A. |
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A Cardiac Transcriptional Enhancer is Repurposed During Regeneration to Activate an Anti-proliferative Program |
| SNP分配用于估计遗传力（SAFE-h2）：一种探索表型基因组起源的工具，用于使用仅加性等位基因效应或加性和非加性等位基因效应估计SNP遗传力 |
Darbani, B. |
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SNP Allocation For Estimating Heritability (SAFE-h2): A tool to explore genomic origins of phenotypes for estimation of SNP heritability using additive-only allelic effects or additive and non-additive allelic effects |
| 炎症诱导的Claudin-2上调通过增强紧密连接调控的胰管运输来限制胰腺炎的进展。 |
Kesaraju, S. |
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Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport |
| 展望未来：利用双翅目-沃尔巴克氏体系统的转录组元分析来预测虫媒病毒策略的可持续性 |
Mejias, S. |
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N/A |
A look into the the future: using a transcriptomic meta-analysis of Diptera-Wolbachia systems to project sustainability of arboviral strategies |
| 腭部结构对中面部前后向生长的贡献 |
Welsh, I. C. |
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N/A |
Palatal segment contributions to midfacial anterior-posterior growth |
| TreePPL：一种适用于系统发育学的通用概率编程语言 |
Senderov, V. E. |
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TreePPL: A Universal Probabilistic Programming Language for Phylogenetics |
| 组合CRISPR筛选揭示FYN和KDM4为治疗三阴性乳腺癌的协同药物组合靶点 |
Kim, T. |
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Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer |
| 通过基于结构稳定性的筛选，利用易于获取的人工同源序列实现蛋白质结构的高精度预测 |
Tang, J. |
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N/A |
Effective High-Accuracy Prediction of Protein Structures from Easily Obtainable Artificial Homologous Sequences by Structure-Stability-Based Selection |
| 伊朗-安纳托利亚和高加索生物多样性热点地区的进化动力学：石竹科（Caryophyllaceae）中石竹属（Gypsophila）的进化辐射及其驱动因素 |
Madhani, H. |
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Evolutionary dynamics in Irano-Anatolian and Caucasus biodiversity hotspots: Evolutionary radiation and its drivers in Gypsophila (Caryophyllaceae) |
| 选择解释而非性能：基于机器学习的从脑连接预测人类智力的洞察 |
Thiele, J. A. |
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N/A |
Choosing explanation over performance: Insights from machine learning-based prediction of human intelligence from brain connectivity |
| 将梯度提升树应用于QTL定位，并结合Shapley加性解释 |
Ishibashi, T. |
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Applying gradient tree boosting to QTL mapping with Shapley additive explanations |
| 学习到的反应动力学反映了刺激的时序，并在小鼠初级视觉皮层（V1）的浅层编码了时间预期的违反。 |
Knudstrup, S. G. |
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Learned response dynamics reflect stimulus timing and encode temporal expectation violations in superficial layers of mouse V1 |
| BiaPy：生物图像上的可访问深度学习 |
Franco-Barranco, D. |
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N/A |
BiaPy: Accessible deep learning on bioimages |
| 致关节炎小鼠中致病性Th17细胞的TCR谱系向Treg样谱系偏移 |
Llamas-Covarrubias, M. A. |
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The TCRs of pathogenic Th17 cells in arthritogenic mice are shifted toward a Treg-like repertoire |
| 精细尺度的海洋学过程塑造了加拉帕戈斯群岛的海洋生物多样性模式。 |
Holman, L. E. |
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N/A |
Fine-scale oceanographic processes shape marine biodiversity patterns in the Galapagos Islands |
| Celldetective：一款利用人工智能增强的图像分析工具，用于揭示动态细胞相互作用 |
Torro, R. |
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N/A |
Celldetective: an AI-enhanced image analysis tool for unraveling dynamic cell interactions |
| 自然行为的视觉运动协调的低维表示 |
Keshava, A. |
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N/A |
Low-Dimensional Representations of Visuomotor Coordination for Natural Behavior |
| 凝聚素IDC、H4K20me1及核周锚定维持秀丽隐杆线虫X染色体的抑制状态 |
Trombley, J. |
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Condensin IDC, H4K20me1, and perinuclear tethering maintain X chromosome repression in C. elegans |
| 果蝇的背侧扇形体是一个神经化学成分异质的睡眠调节中心。 |
Jones, J. D. |
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The dorsal fan-shaped body is a neurochemically heterogeneous sleep-regulating center in Drosophila |
| 化学遗传学刺激膈肌运动输出和膈肌活动 |
Benevides, E. S. |
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Chemogenetic stimulation of phrenic motor output and diaphragm activity |
| 5-HT1A受体在斑马鱼对潜在威胁的反应及社交性中的作用 |
de Sousa, L. V. X. B. |
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Roles of the 5-HT1A receptor in zebrafish responses to potential threat and in sociality |
| 利用贝叶斯参数估计与条件变分自编码器识别肌肉中的机制与治疗靶点 |
Tune, T. C. |
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N/A |
Identifying mechanisms and therapeutic targets in muscle using Bayesian parameter estimation with conditional variational autoencoders |
| 在口头叙事理解中，大脑状态动态的三部分组织 |
Liu, L. |
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Tripartite organization of brain state dynamics underlying spoken narrative comprehension |
| 基于脑电图的连续语音包络重构的语音接收阈值估计 |
Borges, H. B. |
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N/A |
Speech-reception-threshold estimation via EEG-based continuous speech envelope reconstruction |
| 空转：缺乏线粒体DNA的线粒体表现出差异化的运动性和连接性 |
Chustecki, J. M. |
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Running on empty: Mitochondria without mtDNA exhibit differential motility and connectivity |
| 微生物种群几乎从未以逻辑斯蒂方式增长，也从未以亚线性方式增长。 |
Camacho-Mateu, J. |
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N/A |
Microbial populations hardly ever grow logistically and never sublinearly |
| 限时进食对饮食诱导的肥胖大鼠提供了有限的微胶质免疫代谢改善 |
Jiao, H. |
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Time-restricted feeding provides limited microglial immunometabolic improvements in diet-induced obese rats |
| 情感背景影响有蹄类动物的声纹特征 |
Osiecka, A. N. |
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Emotional contexts influence vocal individuality in ungulates |
| 一个用于筛选巨噬细胞外消化脂蛋白聚集体调节剂的高内涵显微镜药物筛选平台 |
Ma, C.-I. J. |
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N/A |
A high-content microscopy drug screening platform for regulators of the extracellular digestion of lipoprotein aggregates by macrophages |
| 基于模拟的TMEM16家族调查显示，强健的脂质翻转需要一个开放的沟槽 |
Stephens, C. A. |
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Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove |
| 利用二维和三维图像分析工具对成年小鼠脑样本中微胶质细胞形态复杂性进行的比较研究 |
Murray, C. J. |
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A comparison of microglial morphological complexity in adult mouse brain samples using 2-dimensional and 3-dimensional image analysis tools |
| BAK驱动的凋亡孔形成的脂质特征 |
Uren, R. T. |
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A lipid signature of BAK-driven apoptotic pore formation |
| 针对铜绿假单胞菌III型分泌系统PcrV组分的抗人单克隆抗体通过不同的机制发挥中和作用 |
Desveaux, J.-M. |
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N/A |
Neutralizing human monoclonal antibodies that target the PcrV component of the Type III Secretion System of Pseudomonas aeruginosa act through distinct mechanisms |
| 冷冻区动力学的数学建模：向在冷冻疗法中使用热成像仪迈进 |
Ivakhnenko, O. V. |
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N/A |
Mathematical modeling of the frozen zone dynamics: towards using thermal imagers in cryotherapy |
| RSV基因组中的G-四链体：潜在的抗病毒靶点。 |
Bose, D. |
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G-quadruplexes in the RSV genome: potential anti-viral targets. |
| 背内侧纹状体中的神经炎症通过破坏稳态星形胶质细胞功能，导致目标导向行为控制过度。 |
Abiero, A. R. |
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Neuroinflammation in the dorsomedial striatum causes excessive goal-directed action control by disrupting homeostatic astrocyte function |
| 斑马鱼中个体保守神经元微外显子及其主调控因子的表型影响 |
Lopez-Blanch, L. |
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N/A |
Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish |
| FoldMark：通过水印保护蛋白质生成模型 |
ZHANG, Z. |
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N/A |
FoldMark: Protecting Protein Generative Models with Watermarking |
| 评估人类祖先颅牙特征的系统发育信息含量和冗余性 |
Raskin, L. Y. |
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N/A |
Assessing phylogenetic information content and redundancy in hominin craniodental traits |
| Aramchol减轻了小鼠胆道纤维化模型中的纤维化，并阻断了TGFβ诱导的胆管细胞中的纤维炎症介质。 |
Aseem, S. O. |
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N/A |
Aramchol attenuates fibrosis in mouse models of biliary fibrosis and blocks the TGFβ-induced fibroinflammatory mediators in cholangiocytes |
| 人类行为中逐次试验学习后继表征 |
Kahn, A. E. |
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N/A |
Trial-by-trial learning of successor representations in human behavior |
| 基于捕获离子迁移支持的MALDI MS/MS成像的空间蛋白质组学：多重和空间肽鉴定的初步观察 |
Li, M. J. |
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N/A |
Spatial Proteomics by Trapped Ion Mobility supported MALDI MS/MS Imaging: A First Glance into Multiplexed and Spatial Peptide Identification |
| 夜行土豚（Orycteropus afer，管齿目）的眼部特征与视网膜光感受器 |
Peichl, L. |
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N/A |
Eye features and retinal photoreceptors of the nocturnal aardvark (Orycteropus afer, Tubulidentata) |
| 跨平台DNA基序发现与基准测试：探索研究不足的人类转录因子结合特异性 |
Vorontsov, I. E. |
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N/A |
Cross-platform DNA motif discovery and benchmarking to explore binding specificities of poorly studied human transcription factors |
| ER Ca2+水平通过调节STIM1和L型Ca2+通道活性来控制神经调质的分泌。 |
Hoogstraaten, R. I. |
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N/A |
ER Ca2+-levels control neuromodulator secretion by regulating STIM1 and L-type Ca2+-channel activity |
| 溶酶体自主调节髓系细胞状态和免疫反应 |
Tejwani, L. |
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N/A |
Lysosomes cell autonomously regulate myeloid cell states and immune responses |
| 空间限制诱导表皮角质形成细胞的往复迁移，并形成三相上皮 |
Nohara, T. |
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N/A |
Spatial confinement induces reciprocating migration of epidermal keratinocytes and forms triphasic epithelia |
| 在小鼠下呼吸道中进行靶向预处理和细胞移植 |
Kohn, A. |
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N/A |
Targeted pre-conditioning and cell transplantation in the murine lower respiratory tract |
| TMEM55B的丢失通过失调的脂噬作用和线粒体功能调节脂质代谢 |
Qin, Y. |
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N/A |
Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function |
| CEP152与PLK4的结合刺激了激酶活性，从而促进中心粒的组装。 |
Hoffmann, I. |
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N/A |
Binding of CEP152 to PLK4 stimulates kinase activity to promote centriole assembly |
| 信号素4A维持造血干细胞池的功能多样性 |
Toghani, D. |
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N/A |
Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool |
| βTrCP1的过度表达可诱导顺铂诱导的衰老细胞发生细胞死亡。 |
Belmonte-Fernandez, A. |
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N/A |
Overexpression of betaTrCP1 elicits cell death in cisplatin-induced senescent cells |
| 一种与Rett综合征相关的KCNC1变异体破坏了Kv3.1通道从内质网到高尔基体的运输 |
Maureira, D. |
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N/A |
A KCNC1 Variant Linked to Rett Syndrome Disrupts ER to Golgi Trafficking of Kv3.1 Channel |
| NG497对脂肪甘油三酯脂肪酶的急性抑制作用扰乱了人胰岛中胰岛素和胰高血糖素的分泌 |
Kim, L. |
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N/A |
Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion from Human Islets |
| 从在线模式回归线下生物化学顶点实验室：从新冠疫情在线教学模式中汲取的经验教训，以提升基于课程的本科生科研体验 |
Rascon, A. A. |
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N/A |
Pivoting Back to the In-Person Capstone Biochemistry Lab: Lessons Learned from the COVID-19 Online Modality to Improve the Course-based Undergraduate Research Experience |
| 评估生成式人工智能在环境研究科学传播中的质量 |
Worden, D. |
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N/A |
Assessing the quality of generative artificial intelligence for science communication in environmental research |
| 在捕食飞行过程中，蜻蜓目标探测神经元的无线记录 |
Lin, H.-T. |
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N/A |
Wireless recordings from dragonfly target detecting neurons during prey interception flight |
| 慢性可变轻度应激以性别依赖的方式改变了终纹床核前背侧核的转录组和信号传导特性 |
Degroat, T. J. |
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N/A |
Chronic variable mild stress alters the transcriptome and signaling properties of the anterodorsal bed nuceleus of the stria terminalis in a sex-dependent manner |
| 利用蛋白质组学分析和配体结合实验探索神经退行性疾病的新型生物标志物 |
Kenzelmann, A. |
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N/A |
Exploration of novel biomarkers for neurodegenerative diseases using proteomic analysis and ligand-binding assays |
| 非临床和临床环境中的优柔寡断与近期加权证据整合 |
del Rio, M. |
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N/A |
Indecision and recency-weighted evidence integration in non-clinical and clinical settings |
| 血清代谢组学分析显示，轻度认知障碍患者在脂质代谢方面存在性别差异。 |
Diaz Escarcega, R. |
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N/A |
Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism |
| 用于检测盐杆菌慢性感染病毒的优化噬菌斑检测法 |
Navok, S. |
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N/A |
Optimized Plaque Assay for Detecting Chronically Infecting Viruses of Haloarchaea |
| 坏死性凋亡向凋亡信号轴是炎症性肠病的基础 |
Pang, J. |
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N/A |
A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease |
| 异染色质表观突变通过引发线粒体功能障碍，从而赋予抗真菌抵抗力。 |
Fellas, A. |
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N/A |
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance |
| 三种全球大肠杆菌转录调节因子的适应性景观 |
Antunes Westmann, C. |
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N/A |
The adaptive landscapes of three global Escherichia coli transcriptional regulators |
| 温室马铃薯蚜虫（Aulacorthum solani）的初步基因组序列 |
Torres, J. |
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N/A |
Draft genome sequence of the glasshouse-potato aphid Aulacorthum solani |
| invertiaDB：一个跨物种基因组倒位重复数据库 |
Provatas, K. |
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N/A |
invertiaDB: A Database of Inverted Repeats Across Organismal Genomes |
| 多细胞整体控制器代谢负担效应的计算机模拟分析 |
Campanile, G. |
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N/A |
In silico analysis of metabolic burden effects on a multicellular integral controller |
| 多模态状态依赖性连接分析：脑干和基底前脑中的觉醒与自主神经中枢 |
Pourmotabbed, H. |
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N/A |
Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain |
| Srs2/PARI DNA解旋酶介导了酵母和人细胞中染色质桥响应的细胞分离抑制 |
Dam, M. |
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N/A |
Srs2/PARI DNA helicase mediates abscission inhibition in response to chromatin bridges in yeast and human cells |
| 城市共居景观：在ECOLOPES框架下探索欧洲共居土地景观的多样性。 |
Oneto, G. |
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N/A |
Urban Cohabscapes: exploring European Co-Habitative landScapes diversity, in the ECOLOPES framework. |
| 通过mRNA实现人类皮肤再生 |
Li, L. |
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N/A |
Human skin rejuvenation via mRNA |
| 结合细胞学和蛋白质组学的方法表明，海绵Halichondria panicea对本地和外来弧菌的处理存在差异。 |
Marulanda-Gomez, A. M. |
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N/A |
Combined cellular and proteomics approach suggest differential processing of native and foreign vibrios in the sponge Halichondria panicea |
| 不同SARS-CoV-2病毒变种（武汉株、Delta株、Omicron株）在模型动物器官中积累的比较特征 |
Chernov, A. |
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N/A |
COMPARATIVE CHARACTERISTICS OF THE ACCUMULATION OF DIFFERENT VARIANTS OF THE SARS-COV-2 VIRUS (WUHAN, DELTA, OMICRON) IN THE ORGANS OF MODEL ANIMALS |
| 一种伴侣蛋白复合物调控疟原虫细胞器的蛋白质稳态 |
Tissawak, A. |
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N/A |
A Chaperonin Complex Regulates Organelle Proteostasis in Malaria Parasites |
| 植物病原菌红球菌中发现利迪霉素A生物合成基因簇，指导结构修正和分子靶点鉴定 |
Ford, J. J. |
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N/A |
Discovery of lydiamycin A biosynthetic gene cluster in the plant pathogen Rhodococcus fascians guides structural revision and identification of molecular target |
| SARS-CoV-2 EndoU核糖核酸酶调控RNA重组并影响病毒适应性。 |
Zhou, Y. |
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N/A |
SARS-CoV-2 EndoU-ribonuclease regulates RNA recombination and impacts viral fitness. |
| 大肠杆菌K12中tRNA修饰缺陷的协同效应。 |
Bacusmo, J. o. M. |
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N/A |
Synergistic effects of tRNA modification defects in Escherichia coli K12. |
| 同时考虑选择和微生物生成计数，为理解全生物体的进化和生态动态提供了独特的见解。 |
Pearman, W. S. |
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N/A |
Joint consideration of selection and microbial generation count provides unique insights into evolutionary and ecological dynamics of holobionts |
| 霍乱弧菌的谱系和泛基因组多样性在孟加拉国一年内呈现出地理上的变化。 |
Qin, C. |
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N/A |
Vibrio cholerae lineage and pangenome diversity varies geographically across Bangladesh over one year |
| 最近SARS-CoV-2变种被pemivibart谱系中基因和结构相关的单克隆抗体中和 |
Powers, C. |
PDF |
N/A |
Neutralization of recent SARS-CoV-2 variants by genetically and structurally related mAbs of the pemivibart lineage |
| 基于造血干细胞的抗HIV-1基因疗法，配备安全终止开关，以防御和攻击HIV-1感染 |
Guo, Q. |
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N/A |
Anti-HIV-1 HSPC-based gene therapy with safety kill switch to defend against and attack HIV-1 infection |
| 探究intimin/invasin在嗜水气单胞菌（Aeromonas hydrophila）对露比鱼（Labeo rohita）致病性中的潜在作用：宿主-微生物相互作用研究 |
Bhattacharyya, A. |
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N/A |
Investigating the potential role of intimin/invasin in Aeromonas hydrophila virulence in Labeo rohita: a host-microbe interaction study |
| 绘制按蚊雌蚊中疟原虫的转变与相互作用 |
Yan, Y. |
PDF |
N/A |
Mapping Plasmodium transitions and interactions in the Anopheles female |
| 元蛋白质组学揭示了仓鼠感染SARS-CoV-2后肠道微生物组的年龄特异性改变 |
Creskey, M. |
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N/A |
Metaproteomics reveals age-specific alterations of gut microbiome in hamsters with SARS-CoV-2 infection |
| 人类ClpXP的冷冻电镜结构揭示了其组装和蛋白水解激活的机制 |
Chen, W. |
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N/A |
Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation |
| 寄生线虫单细胞核分离与RNA测序的优化 |
Buddenborg, S. K. |
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N/A |
Optimisation of single-nuclei isolation and RNA sequencing of parasitic nematodes |
| 整合石莼功能基因组学：基因编辑与新型筛选系统 |
Blomme, J. |
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Consolidating Ulva functional genomics: Gene editing and new selection systems |
| 小分子抑制剂联合治疗能有效抑制弥漫性大B细胞淋巴瘤中的B细胞信号传导。 |
Witmond, M. |
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Small molecule inhibitor combination treatment effectively represses global B-cell signaling in diffuse large B-cell lymphoma |
| SARS-CoV-2 XEC变体的免疫逃逸、细胞融合及刺突蛋白稳定性：N端结构域糖基化突变的作用 |
Li, P. |
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N/A |
Immune Evasion, Cell-Cell Fusion, and Spike Stability of the SARS-CoV-2 XEC Variant: Role of Glycosylation Mutations at the N-terminal Domain |
| 细菌乙酰转移酶PatZ的催化及变构机制的结构基础 |
Park, J. B. |
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Structural basis of the catalytic and allosteric mechanism of bacterial acetyltransferase PatZ |
| 病毒感染期间ATP分配的动态代谢建模 |
Lu, A. |
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Dynamic metabolic modeling of ATP allocation during viral infection |
| 端粒转座子广泛存在于线性细菌基因组中。 |
Hsieh, S.-C. |
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N/A |
Telomeric transposons are pervasive in linear bacterial genomes |
| G蛋白偶联受体17通过Gi/o依赖机制抑制肠内分泌细胞中胰高血糖素样肽-1的分泌 |
Conley, J. M. |
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G protein-coupled receptor 17 inhibits glucagon-like peptide-1 secretion via a Gi/o-dependent mechanism in enteroendocrine cells |
| 有丝分裂中的CIP2A-TOPBP1轴促进MiDAS与MMEJ之间的有丝分裂途径选择。 |
Martin, P. R. |
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The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ |
| 由细菌微区室封装肽驱动的生物分子凝聚的蓝图 |
Trettel, D. |
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N/A |
A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides |
| 在不确定性下的遗传电路风险规避优化 |
Kobiela, M. |
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N/A |
Risk-averse optimization of genetic circuits under uncertainty |