| MIRAGE：一种结合变异功能信息的贝叶斯稀有变异关联分析方法 |
Han, S. |
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N/A |
MIRAGE: a Bayesian rare variant association analysis method incorporating functional information of variants |
| UFMTrack：下流迁移追踪器，能够在微流控设备中对跨越血脑屏障的整个多步骤免疫细胞渗出级联进行分析 |
Vladymyrov, M. |
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N/A |
UFMTrack: Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices |
| 基因组大小进化与毒蛙科（Dendrobatidae）的表型关联 |
Douglas, T. E. |
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N/A |
Genome size evolution and phenotypic correlates in the poison frog family Dendrobatidae |
| 古代和现代伊比利亚牛中野牛杂交的基因组遗产 |
Günther, T. |
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N/A |
The Genomic Legacy of Aurochs hybridization in ancient and modern Iberian Cattle |
| 人类额叶皮层的刺激表征支持工作记忆中的灵活控制 |
Shao, Z. |
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N/A |
Stimulus representation in human frontal cortex supports flexible control in working memory |
| 鞘脂调控的突触核蛋白-1包涵体的成熟与解毒作用 |
Cao, X. |
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N/A |
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids |
| 复杂性状的普遍多基因性会夸大转录组全关联研究中的假阳性率 |
Liang, Y. |
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N/A |
Pervasive polygenicity of complex traits inflates false positive rates in transcriptome-wide association studies |
| 行为药理学预测阿尔茨海默病风险基因斑马鱼突变体中的信号通路紊乱及候选治疗药物 |
Kroll, F. |
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N/A |
Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer's disease risk genes |
| 焦点粘附内整合素纳米簇的空间差异调控与激活 |
Keary, S. |
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N/A |
Differential spatial regulation and activation of integrin nanoclusters inside focal adhesions |
| TIPPo：一种用户友好的工具，用于利用HiFi数据从头组装细胞器基因组 |
Xian, W. |
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N/A |
TIPPo: A User-Friendly Tool for De Novo Assembly of Organellar Genomes with HiFi Data |
| 环境和种内及种间相互作用都会影响海洋捕食者的移动。 |
Mourier, J. |
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N/A |
Both environmental conditions and intra- and interspecific interactions influence the movements of a marine predator |
| 所有细菌基因组 - 已组装、可用且可搜索的所有细菌基因组 |
Hunt, M. |
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N/A |
AllTheBacteria - all bacterial genomes assembled, available and searchable |
| 一刀切不可取：确定远程相机陷阱实际视野范围的新方法 |
Carswell, B. M. |
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N/A |
One size does not fit all: a novel approach for determining the Realised Viewshed Size for remote camera traps |
| 协调印度各地的树木库存数据集可以填补热带生态学中的关键空白。 |
Anujan, K. |
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N/A |
Harmonising distributed tree inventory datasets across India can fill critical gaps in tropical ecology |
| 基于深度学习的细胞骨架分割技术，用于精确高效地测量细胞骨架密度 |
Horiuchi, R. |
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N/A |
Deep learning-based cytoskeleton segmentation for accurate high-throughput measurement of cytoskeleton density |
| 使用Zarr进行生物银行规模分析就绪的VCF |
Czech, E. A. |
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N/A |
Analysis-ready VCF at Biobank scale using Zarr |
| 紧密匹配的比较表明，可分离的过程介导了上下文大小错觉。 |
Schwarzkopf, D. S. |
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N/A |
Closely matched comparisons suggest that separable processes mediate contextual size illusions |
| 一个低活动性的皮层网络专门编码句法 |
Morgan, A. M. |
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N/A |
A low-activity cortical network selectively encodes syntax |
| 视觉隐性学习中的结构转移与巩固 |
Garber, D. |
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N/A |
Structure transfer and consolidation in visual implicit learning |
| 结合AI与MD模拟，发现猴痘病毒H3中的硫酸乙酰肝素结合域作为抗痘病毒药物靶点 |
Zheng, B. |
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N/A |
Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combing AI and MD Simulations |
| 新热带生物多样性指标的基因组学：两种蝴蝶辐射，伴随着广泛的染色体重排和杂交 |
van der Heijden, E. S. |
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N/A |
Genomics of Neotropical biodiversity indicators: two butterfly radiations with rampant chromosomal rearrangements and hybridisation |
| 共享环境使得利用菌株解析的宏基因组学来推断微生物群落传播变得复杂。 |
Debray, R. |
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N/A |
Shared environments complicate the use of strain-resolved metagenomics to infer microbiome transmission |
| HSPA2在卵裂球中的不对称表达决定了胚胎的第一次细胞命运决定。 |
Gao, J. |
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N/A |
The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision |
| 小脑浦肯野细胞直接输出到脑干的特征 |
Chen, C. H. |
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N/A |
Characterization of direct Purkinje cell outputs to the brainstem |
| 数据引导的人类成纤维细胞直接重编程为造血谱系 |
Stansbury, C. |
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N/A |
Data-guided direct reprogramming of human fibroblasts into the hematopoietic lineage |
| 是的，它们都是独立的个体：用于重复调查数据的层次模型能够改进对树木生长和尺寸的估计。 |
O'Brien, T. |
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N/A |
Yes, they're all individuals: Hierarchical models for repeat survey data improve estimates of tree growth and size |
| 细胞-细胞外基质（ECM）粘附的局部减弱通过细胞形态、肌动蛋白-肌球蛋白组织和E-钙粘蛋白水平的变化，触发了基底组织的折叠。 |
Valencia-Exposito, A. |
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N/A |
Local weakening of cell-ECM adhesion triggers basal tissue folding via changes in cell shape, actomyosin organization and E-cad levels |
| 饮食诱导的肥胖中，时间限制性进食对小胶质细胞代谢的改善有限 |
Jiao, H. |
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N/A |
Limited microglial metabolic improvement with time-restricted feeding in diet-induced obesity |
| 抑制去泛素化酶活性和炎症信号传导的分子胶 |
Chandler, F. |
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N/A |
Molecular glues that inhibit deubiquitylase activity and inflammatory signalling |
| 质子化/去质子化驱动的低电位铁氧还蛋白氧化还原稳定性开关 |
Wada, K. |
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N/A |
Protonation/deprotonation-driven switch for the redox stability of low-potential ferredoxin |
| 单细胞微藻生命周期中r策略与K策略的转变 |
Liu, L. |
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N/A |
A shift between r and K strategies in the life cycle of a unicellular microalga |
| 相机陷阱无法确定橡皮泥制作的毛毛虫模型是否能可靠地测量鸟类捕食情况。 |
SCHILLE, L. |
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N/A |
Camera traps unable to determine whether plasticine models of caterpillars reliably measure bird predation |
| 脂滴靶向ABHD5和PNPLA3 I148M是促进肝脏脂肪变性所必需的 |
Teskey, G. |
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N/A |
Lipid Droplet Targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosis |
| 光化学分析突触和突触外NMDA受体分子多样性 |
Sicard, A. |
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N/A |
Optochemical profiling of NMDA receptor molecular diversity at synaptic and extrasynaptic sites |
| 贫血和组织缺氧是疟疾低乳酸血症的主要决定因素。 |
Georgiadou, A. |
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N/A |
Anemia and tissue hypoxia are major determinants of malarial hypelactatemia |
| 撤回：MIRAGE：一种结合变异功能信息的贝叶斯稀有变异关联分析方法 |
Han, S. |
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N/A |
WITHDRAWN: MIRAGE: a Bayesian rare variant association analysis method incorporating functional information of variants |
| NACHO介导的五聚配体门控离子通道组装机制 |
Hooda, Y. |
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N/A |
Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels |
| 从单个词汇到句子生成：共享的皮层表征，但时间动态不同 |
Morgan, A. M. |
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N/A |
From single words to sentence production: Shared cortical representations but distinct temporal dynamics |
| 光流解析作为因果源分离：一种从光流中并行提取物体和自运动信息的计算模型 |
Scherff, M. |
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N/A |
Flow parsing as causal source separation: A computational model for concurrent retrieval of object and self-motion information from optic flow |
| 多维社会关系塑造了猴子的社会关注 |
Liu, S. |
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N/A |
Multi-dimensional social relationships shape social attention in monkeys |
| QT-WEAVER：纠正四重分布尽管基因树估计错误，仍能提高系统基因组学分析 |
Hasan, N. B. |
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N/A |
QT-WEAVER: Correcting quartet distribution improves phylogenomic analyses despite gene tree estimation error |
| 杨树：一种系统发育分析流程 |
Koning, E. |
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N/A |
Poplar: A Phylogenetics Pipeline |
| 影响贝宁北部被忽视和未充分利用物种消费趋势的食品环境因素 |
BANKOLE, B. M. V. |
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N/A |
Food environment components influencing consumption trends of neglected and underutilized species in northern Benin |
| 长春新碱治疗逆转局灶节段性肾小球硬化中的足细胞损伤 |
Mason, W. J. |
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N/A |
Vincristine treatment reverses podocyte damage in focal segmental glomerulosclerosis |
| 确认气候变化对生物多样性的影响：全球调查结果 |
Alshehab, E. A. |
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N/A |
Confirming the Impact of Climate Change on Biodiversity: Results from a Global Survey |
| AGAPE（计算G四链体亲和力预测）：首个用于G四链体结合亲和力预测的AI体内工作流程。 |
D'Anna, L. |
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N/A |
AGAPE (computAtional G-quadruplex Affinitiy PrEdiction): The first AI In-silico workflow for G-quadruplex binding affinity prediction. |
| CPSM：用于预测单个癌症患者生存概率的自动化机器学习管道的R包 |
Kaur, H. T. |
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N/A |
CPSM: R-package of an Automated Machine Learning Pipeline for Predicting the Survival Probability of Single Cancer Patient |
| 分层糖酵解途径调控人类肠道拟杆菌中碳水化合物利用调节因子 |
Kabonick, S. G. |
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N/A |
Hierarchical glycolytic pathways control the carbohydrate utilization regulator in human gut Bacteroides |
| ABA通过提高苹果根系中的脂肪酸水平，促进丛枝菌根真菌的定殖。 |
Jing, S. |
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N/A |
ABA increases fatty acids levels in apple roots to boost colonization by arbuscular mycorrhizal fungi |
| 非模式纤毛虫奇洛顿内拉·翁西纳塔（Chilodonella uncinata）的基因组内容：对其核结构、发育过程中体细胞大核内总DNA中基因大小染色体的见解 |
Ahsan, R. |
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N/A |
Genome content in the non-model ciliate Chilodonella uncinata: insights into nuclear architecture, gene-sized chromosomes among the total DNA in their somatic macronuclei during their development |
| 在典型的“活化石”谱系中，表型进化的变异模式 |
Rivero-Vega, R. A. |
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N/A |
Variable patterns of phenotypic evolution among canonical 'living fossil' lineages |
| 靶向降解易凝结的内源蛋白质可提高作物性能 |
Xu, G. |
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N/A |
Targeted degradation of endogenous condensation-prone proteins improves crop performance |
| 叶面积大小决定了玉米在受损和植食性昆虫诱导下挥发性物质的释放量。 |
Waterman, J. M. |
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N/A |
Leaf size determines damage- and herbivore-induced volatile emissions in maize |
| 大海捞针：从植物根部培养对植物有益的柔膜菌目菌株 |
Bruyant, P. |
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N/A |
Needle in a haystack: culturing plant-beneficial Helotiales lineages from plant roots |
| 野猪源微生物移植对仔猪微生物群、代谢物谱及肠道促炎细胞因子产生的影响与母猪源微生物移植不同。 |
Willing, B. P. |
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N/A |
The impact of wild-boar derived microbiota transplantation on piglet microbiota, metabolite profile and gut proinflammatory cytokine production differs from sow-derived microbiota |
| 从初始多能性到人类神经类器官：通过三维形态发生连续体 |
Laterza, C. |
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N/A |
From naïve pluripotency to human neural organoids through a three-dimensional morphogenetic continuum |
| 特瓦坎谷的种子传播效果及植物-鸟类相互作用网络 |
Contreras-Gonzalez, A. M. |
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N/A |
Seed dispersal effectiveness and plant-bird interaction networks in the Tehuacan Valley |
| 地中海植物物种与食草性节肢动物的关联及其对有机葡萄园中害虫数量的影响 |
Santos, R. |
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N/A |
The association of Mediterranean plant species with herbivorous arthropods and its effect on pest abundance in organic vineyards |
| 通过结构建模和分化时间估算，理解植物和真菌病毒中RNA聚合酶的进化和功能关系 |
Gracy, J. |
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N/A |
Understanding evolutionary and functional relationships of RNA polymerases in plant and fungal viruses through structural modeling and divergence date estimations |
| 斑胸草雀对鸣叫类型的分类和语义感知 |
Elie, J. E. |
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N/A |
Categorical and semantic perception of the meaning of call-types in zebra finches |
| 玩还是不玩？玩伴熟悉度和社会隔离对三种实验室大鼠社交玩耍参与度的影响 |
Orsucci, I. C. |
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N/A |
To Play or Not to Play? Effects of Playmate Familiarity and Social Isolation on Social Play Engagement in Three Laboratory Rat Strains |
| 光捕获复合物II通过脂质再分配抵抗植物类囊体膜中非双层脂质诱导的多态性 |
Garg, A. |
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N/A |
Light Harvesting Complex II Resists Non-Bilayer Lipid-Induced Polymorphism in Plant Thylakoid Membranes via Lipid Redistribution |
| 双子叶植物茎对低红光：远红光的响应中的皮层细胞反应 |
Li, L. |
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N/A |
Pith cell responses to low red: far-red light in dicot stems |
| 植物原生质体的动态皮层行为揭示了植物和动物细胞之间意想不到的相似性 |
Dickmann, J. E. M. |
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N/A |
Dynamic cortical behavior of plant protoplasts reveals unexpected similarities between plant and animal cells |
| 拟南芥I类成形蛋白AtFH5有助于幼苗抵抗盐胁迫。 |
Kollarova, E. |
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N/A |
The Arabidopsis Class I formin AtFH5 contributes to seedling resistance to salt stress. |
| 高可塑性增加了表型与环境的错配，导致未充分利用的作物物种表现不佳。 |
Alagarasan, G. |
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N/A |
High plasticity increases phenotype-environment mismatch leading to sub-optimal performance in underutilized crop species |
| 寡聚半乳糖醛酸，由甜菜副产品的酶促降解产生，对小麦白粉病具有部分保护作用。 |
Carton, C. |
PDF |
N/A |
Oligogalacturonides, produced by enzymatic degradation of sugar beet by-products, confer partial protection against wheat powdery mildew |
| 大豆胞囊线虫抗性蛋白AATRhg1影响氨基酸稳态和甜菜色素积累 |
Du, Y. |
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N/A |
Soybean Cyst Nematode-Resistant Protein AATRhg1 Affects Amino Acid Homeostasis and Betalain Accumulation |
| 内生蚯蚓提取物对“促植物生长真菌”的影响 |
Yakkou, L. |
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N/A |
Effect of endogenous earthworm's extracts on "plant growth-promoting fungi" |
| 晚分生组织身份2调控种子表面的角质层形成，并影响种子的寿命。 |
Oshima, Y. |
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N/A |
LATE MERISTEM IDENTITY2 regulates cuticle formation on the seed surface and influences seed longevity |
| 光系统II组装因子RBD1和HCF136的拮抗作用是植物叶绿体中光调控psbA翻译的基础 |
Rojas, M. |
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N/A |
Opposing action of photosystem II assembly factors RBD1 and HCF136 underlies light-regulated psbA translation in plant chloroplasts |
| 半冬性甘蓝型油菜品种中双11中FLOWERING LOCUS T相关基因的特征及其潜在的基因调控网络 |
Wang, J. K. |
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N/A |
Characterization of FLOWERING LOCUS T related genes and their putative gene regulatory network in semi-winter Brassica napus cultivar Zhongshaung11 |
| 在黑暗条件下，早期幼苗的发育直接受到质体通过GUN1依赖性质体逆行途径的调控。 |
Sajib, S. A. |
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N/A |
Early seedling development in dark conditions is directly controlled by plastids through the GUN1-dependent plastid retrograde pathway |
| 通过机器学习解密植物复杂的表现型特征 |
Zdrazil, J. |
PDF |
N/A |
Decrypting the complex phenotyping traits of plants by machine learning |
| 乳酸片球菌在酸性胁迫下形态变化的计算分析 |
Venugopal, A. |
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N/A |
Computational analysis of morphological changes in Lactiplantibacillus plantarum under acidic stress |
| UCE系统发育基因组学揭示了收获蚁属（Pogonomyrmex）的系统分类学和地理分布范围的演化 |
Graber, L. C. |
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N/A |
UCE phylogenomics inform the systematics and geographic range evolution of the harvester ant genus Pogonomyrmex |
| 复合序列基序的信息论：复杂分子识别的突变和生物物理决定因素 |
Mascolo, E. |
PDF |
N/A |
Information Theory of Composite Sequence Motifs: Mutational and Biophysical Determinants of Complex Molecular Recognition |
| 植物类囊体膜边缘区域的脂质多态性 |
Böde, K. |
PDF |
N/A |
Lipid polymorphism of the marginal region of plant thylakoid membranes |
| SSNA1自组装及其微管结合在中心粒维持中的结构洞察 |
Agostini, L. |
PDF |
N/A |
Structural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance |
| 脂质翻转酶ATP9A和ATP9B形成复合体，并参与从高尔基体到分泌途径的贡献。 |
Yagi, T. |
PDF |
N/A |
Lipid flippases ATP9A and ATP9B form a complex and contribute to the secretory pathway from the Golgi apparatus |
| Smc5/6与微管的结合调控着动态的着丝粒周围染色质折叠 |
Carre-Simon, A. |
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N/A |
Smc5/6 association with microtubules controls dynamic pericentromeric chromatin folding |
| 上游开放阅读框在果蝇进化和发育过程中缓冲翻译变异性 |
Sun, Y. |
PDF |
N/A |
Upstream open reading frames buffer translational variability during Drosophila evolution and development |
| 昆虫在CENP-T蛋白家族中进化出了单体组蛋白折叠结构域 |
Sankaranarayanan, S. R. |
PDF |
N/A |
Insects evolved a monomeric histone-fold domain in the CENP-T protein family |
| 一种新型秀丽隐杆线虫Tau扩散模型揭示了内溶酶体完整性和种子Tau聚集的关键基因 |
Sandhof, C. A. |
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N/A |
A Novel C. elegans Model for Tau spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation |
| Pin4 链接：酵母中葡萄糖饥饿后的转录后和转录反应 |
Ristova, M. |
PDF |
N/A |
Pin4 Links Post-transcriptional and Transcriptional Responses to Glucose Starvation in Yeast |
| 跨物种类器官揭示了多巴胺能神经元发育和脆弱性的人类特异性分子特征 |
Nolbrant, S. |
PDF |
N/A |
Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability |
| 妊娠期长度驱动有胎盘哺乳动物的大脑尺寸和胎仔数量变化 |
Danis, T. |
PDF |
N/A |
Gestation length drives brain size and litter size variation in eutherian mammals |
| AI辅助成像筛查揭示了机械分子组织者和信号枢纽网络。 |
Bertocchi, C. |
PDF |
N/A |
AI-assisted imaging screening reveals mechano-molecular tissue organizers and network of signaling hubs. |
| TopLib：构建和搜索自上而下的质谱库，用于蛋白质变体鉴定 |
Li, K. |
PDF |
N/A |
TopLib: Building and searching top-down mass spectral libraries for proteoform identification |
| iModMix：多组学数据的综合模块分析 |
Narvaez-Bandera, I. Y. |
PDF |
N/A |
iModMix: Integrative Module Analysis for Multi-omics Data |
| VIRALpre：融合K-mer特征的病毒基因组基础模型嵌入用于病毒识别 |
Wang, Z. |
PDF |
N/A |
VIRALpre: Genomic Foundation Model Embedding Fused withK-mer Feature for Virus Identification |
| AlphaRING：通过蛋白质建模和残基相互作用网络分析进行错义变异分类 |
Logsdon, A. |
PDF |
N/A |
AlphaRING: Missense Variant Classification via Protein Modelling and Residue Interaction Network Analysis |
| 利用基因表达数据预测多发性骨髓瘤分期和MGUS进展的机器学习模型 |
Karathanasis, N. |
PDF |
N/A |
Machine Learning Models for Predicting Multiple Myeloma Staging and MGUS Progression Using Gene Expression Data |
| 肌球蛋白II细丝结构特性对力生成的影响 |
Ding, S. |
PDF |
N/A |
Impacts of Structural Properties of Myosin II Filaments on Force Generation |
| 在乳腺癌中，维持CDK4/6抑制剂并结合CDK2抑制剂超越进展的治疗益处 |
Armand, J. |
PDF |
N/A |
Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer |
| 昼夜节律基因Dec2通过调控肿瘤细胞抗原呈递促进免疫逃逸，从而促进胰腺癌休眠。 |
Harris, C. R. |
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N/A |
The circadian gene Dec2 promotes pancreatic cancer dormancy by regulating tumor cell antigen presentation to facilitate immune evasion |
| 啮齿动物的垂直袖状胃切除术：对母亲代谢、心血管和肝脏功能的影响及围产期后果 |
Payen, C. |
PDF |
N/A |
Vertical sleeve gastrectomy in rodents: impact on metabolic, cardiovascular and hepatic functions of mothers and perinatal consequences |
| 需要能力建设以充分利用获取生物多样性收藏的益处 |
Groom, Q. |
PDF |
N/A |
Capacity building needed to reap the benefits of access to biodiversity collections |
| T细胞介导的克罗恩病上皮完整性损害 |
Hamoudi, S. |
PDF |
N/A |
T cell mediated impairment of epithelial integrity in Crohn's disease |
| 慢性炎症驱动附睾三级淋巴结构形成和自身免疫性生育障碍 |
Elizagaray, M. L. |
PDF |
N/A |
Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders |
| ENTPD3特异性CAR调节性T细胞用于T1D的局部免疫控制 |
Pieper, T. |
PDF |
N/A |
ENTPD3-specific CAR Regulatory T cells for Local Immune Control in T1D |
| AIP56是由杀鱼气单胞菌（Photobacterium damselae subsp. piscicida）分泌的一种AB毒素，它对髓系细胞具有趋向性。 |
Freitas, I. L. |
PDF |
N/A |
AIP56, an AB toxin secreted by Photobacterium damselae subsp. piscicida, has tropism for myeloid cells |
| LTB4通过一种受体转激活机制被转化为一种强效的人类中性粒细胞NADPH氧化酶激活剂，其中BLT1受体激活游离脂肪酸受体2。 |
Wu, Y. |
PDF |
N/A |
LTB4 is converted into a potent human neutrophil NADPH oxidase activator via a receptor transactivation mechanism in which the BLT1 receptor activates the free fatty acid receptor 2 |
| 计算机生物群落区划方法 |
Sukhanov, V. |
PDF |
N/A |
Computer method of biocenotic zoning |
| 火灾后的幼苗更新：解开微生境条件和种子可获得性的作用 |
Beck, J. J. |
PDF |
N/A |
Seedling recruitment after fire: Disentangling the roles of microsite conditions and seed availability |
| 填补基因组空白：草类作物进化中的泛草类同源基因集 |
Dias, H. M. |
PDF |
N/A |
Bridging Genomic Gaps: The Pan-Grass Syntenic Gene Set in Grass Crop Evolution |
| DreaM：一种用于增强重复基因组区域短读序列分析的计算流程 |
Kumar, S. |
PDF |
N/A |
DreaM: A Computational Pipeline for Enhanced Short-Read Sequence Analysis in Repetitive Genomic Regions |
| 揭示与乳腺癌发展相关的表观遗传调控元件 |
Jardanowska-Kotuniak, M. |
PDF |
N/A |
Unveiling epigenetic regulatory elements associated with breast cancer development |
| 通过大量和单细胞RNA测序揭示的诺林在神经视网膜分化中的潜在作用 |
Maggi, K. |
PDF |
N/A |
Putative Role of Norrin in Neuroretinal Differentiation Revealed by bulk and scRNA Sequencing of Human Retinal Organoids |
| 在纳米尺度上，左旋多巴与脑部疾病蛋白质的相互作用 |
Bergaglio, T. |
PDF |
N/A |
On Levodopa interactions with brain disease proteins at the nanoscale |
| 人类肠神经胶质在急性脑损伤临床前模型中的再生潜力 |
Colitti, N. |
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N/A |
Regenerative potential of human enteric glia in a preclinical model of acute brain injury |
| 盲点填补是多感官的 |
Chan, A. |
PDF |
N/A |
Filling-in of the Blindspot is Multisensory |
| 人脑中的区域脑熵、脑网络及结构-功能耦合 |
Song, D. |
PDF |
N/A |
Regional Brain Entropy, Brain Network and Structural-Functional Coupling in Human Brain |
| 用于与神经退行性疾病研究界共享的额颞叶痴呆单MAPT敲入小鼠模型 |
Morito, T. |
PDF |
N/A |
Single MAPT knock-in mouse models of frontotemporal dementia for sharing with the neurodegenerative research community |
| 急性低氧性缺氧对大脑血流反应性的变异性 |
Johnson, H. R. |
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N/A |
Variable Cerebral Blood Flow Responsiveness to Acute Hypoxic Hypoxia |
| 睡眠剥夺后的注意力失误代表了脑脊液流动的瞬间。 |
Yang, Z. |
PDF |
N/A |
Attentional failures after sleep deprivation represent moments of cerebrospinal fluid flow |
| 单细胞分析显示，单核细胞基因表达谱影响急性治疗队列中HIV-1储库的大小 |
Ehrenberg, P. K. |
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N/A |
Single-cell analyses reveal that monocyte gene expression profiles influence HIV-1 reservoir size in acutely treated cohorts |
| 一种与侧位、心脏和肾脏缺陷相关的人类WNT11功能丧失型纯合变异 |
Berns, H. E. |
PDF |
N/A |
A homozygous human WNT11 loss-of-function variant associated with laterality, heart and renal defects |
| 骨形态发生蛋白信号通路与乙醇相互作用破坏了腭的形成，与gata3无关 |
Lovely, C. B. |
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N/A |
Bone Morphogenetic Protein signaling pathway - ethanol interactions disrupt palate formation independent of gata3 |
| 城市绿地连通性促使宿主群落变化及蜱传病原体感染转变 |
VanAcker, M. C. |
PDF |
N/A |
Urban greenspace connectivity drive shifts in host assemblages and tick-borne pathogen infection |
| 将机器学习与流式成像显微技术相结合，实现藻华的自动化监测 |
Khan, F. |
PDF |
N/A |
Integrating Machine Learning with Flow-Imaging Microscopy for Automated Monitoring of Algal Blooms |
| 长读测序揭示了在无脊椎动物-脊椎动物过渡阶段，细胞间信号传导的关键转录因子效应物中同工型多样性的增加 |
Torres-Aguila, N. P. |
PDF |
N/A |
Long-Read Sequencing Reveals Increased Isoform Diversity in Key Transcription Factor Effectors of Intercellular Signalling at the Invertebrate-Vertebrate Transition |
| 增强GPT模型在基因组学分析中的应用：通过RAG和微调生成可信的遗传变异注释与解读 |
Lu, S. |
PDF |
N/A |
Boosting GPT Models for Genomics Analysis: Generating Trusted Genetic Variant Annotations and Interpretations through RAG and fine-tuning |
| 组织微环境中的破坏性变化在肺癌发生不同阶段促进了致癌过程的启动。 |
Venkat, V. |
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N/A |
Disruptive changes in tissue microenvironment prime oncogenic processes at different stages of carcinogenesis in lung |
| 体积和扩散张量成像生物标志物表明，在轻度创伤性脑损伤的青年猪模型中，存在长期持续的脑震荡后异常。 |
Islam, S. |
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N/A |
Volumetric and Diffusion Tensor Imaging biomarkers indicating long lasting post-concussion abnormalities in a youth pig model of mild Traumatic Brain Injury |
| 多级混合制备核壳结构显著提升载DNA脂质纳米粒的转染效率，提升幅度达数量级。 |
Nong, J. |
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N/A |
Multi-stage-mixing to create a core-then-shell structure improves DNA-loaded lipid nanoparticles transfection by orders of magnitude |
| 通过多重电化学实时局部炎症追踪一氧化氮传感器（MERLIN）进行伤口状态监测 |
Wang, L. |
PDF |
N/A |
Wound state monitoring by multiplexed, electrochemical, real-time, localized, inflammation-tracking nitric oxide sensor (MERLIN) |
| HSPB5中的蛋白稳态相关变异破坏了αB-晶体蛋白结构域的稳定性 |
Khatun, M. S. |
PDF |
N/A |
Proteostasis Associated Variants in HSPB5 Destabilize the αB-crystallin Domain |
| 使用MMseqs2进行GPU加速的同源搜索 |
Kallenborn, F. |
PDF |
N/A |
GPU-accelerated homology search with MMseqs2 |
| 使用参数高效的迁移学习进行免疫蛋白的精确结构预测 |
Zhu, T. |
PDF |
N/A |
Accurate structure prediction of immune proteins using parameter-efficient transfer learning |
| 用于芽殖酵母无标记基因编辑的自动化质粒设计 |
Stojkovic, L. |
PDF |
N/A |
Automated plasmid design for marker-free genome editing in budding yeast |
| scMoE：通过稀疏专家混合实现单细胞多模态多任务学习 |
Yun, S. |
PDF |
N/A |
scMoE: single-cell Multi-Modal Multi-Task Learning via Sparse Mixture-of-Experts |
| 人类5' UTR序列的多目标计算优化 |
Yamada, K. |
PDF |
N/A |
Multi-objective computational optimization of human 5' UTR sequences |
| scTrace+：通过整合谱系追踪和多方面的转录组相似性信息来增强细胞命运推断 |
Guo, W. |
PDF |
N/A |
scTrace+: enhance the cell fate inference by integrating the lineage-tracing and multi-faceted transcriptomic similarity information |
| 中期染色单体表面凝聚的核内分区 |
Murugesan, V. |
PDF |
N/A |
Nuclear partitioning by surface condensation on metaphase chromatids |
| 评估NF1突变肿瘤细胞中治疗性自噬抑制的效果 |
Zahedi, S. |
PDF |
N/A |
The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cells |
| 针对SLC7A11介导的半胱氨酸代谢治疗曲妥珠单抗耐药的HER2阳性乳腺癌 |
Hua, Y. |
PDF |
N/A |
Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer |
| 精子甲基组对衰老和应激反应的分子基础 |
Arowolo, O. |
PDF |
N/A |
Molecular Basis of Sperm Methylome Response to Aging and Stress |
| 视觉系统中正向和反向α波段传播波的分层多尺度模型 |
Schwenk, J. C. B. |
PDF |
N/A |
A hierarchical multiscale model of forward and backward alpha-band traveling waves in the visual system |
| 高分辨率成像图谱揭示了胰腺交感神经支配在糖尿病小鼠中的情境依赖性作用 |
Xu, Q. |
PDF |
N/A |
High-resolution imaging atlas reveals context-dependent role of pancreatic sympathetic innervation in diabetic mice |
| 国际多队列分析揭示了量化重症疾病中免疫失调的新框架：SUBSPACE联盟研究结果 |
Moore, A. R. |
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N/A |
International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium |
| 肺泡巨噬细胞在纳米颗粒吸入过程中启动空间定向的中性粒细胞招募 |
Liu, Q. |
PDF |
N/A |
Alveolar macrophages initiate the spatially targeted neutrophil recruitment during nanoparticle inhalation |
| 年老的秀丽隐杆线虫（Caenorhabditis elegans）的抗病毒防御能力下降，这是由于DRH-1/RIG-I的去SUMO化作用通过ULP-4/SENP7的丧失所导致的。 |
Zhang, Y. |
PDF |
N/A |
Antiviral defense in aged Caenorhabditis elegans declines due to loss of DRH-1/RIG-I deSUMOylation via ULP-4/SENP7 |
| 通过近红外光谱和云端神经网络实现生物制剂的快速原位检测 |
Leseigneur, C. |
PDF |
N/A |
Rapid and In-situ Detection of Biological Agents via Near-Infrared Spectroscopy and Cloud-Powered Neural Networks |
| 一项针对肝脏染色体结构的全基因组图谱研究表明，性别决定了饮食诱导的核小体动力学。 |
ZHANG, Z. |
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N/A |
A genome-wide ATLAS of liver chromatin architecture reveals that sex dictates diet-induced nucleosome dynamics |
| 自发性高血压易卒中大鼠尿液蛋白质组特征分析 |
Meng, W. |
PDF |
N/A |
Urinary Proteome Characterization of Stroke-Prone Spontaneously Hypertensive Rats |
| 土耳其商业一品红中相关桃树植原体候选菌株的出现 |
Benlioglu, K. |
PDF |
N/A |
Occurrence of a Candidatus Phytoplasma pruni Related Strain Associated with Commercial Poinsettias in Turkey |
| 元基因组学洞察：氨回收生物反应器中参与N2O缓解和反硝化还原为氨的活性细菌 |
Phan, H. V. |
PDF |
N/A |
Meta-omic insights into active bacteria mediating N2O mitigation and dissimilatory nitrate reduction to ammonium in an ammonia recovery bioreactor |
| 顺应潮流：利用礁石尺度的水动力学进行基于幼虫的恢复的规模扩大 |
Gouezo, M. |
PDF |
N/A |
Going with the flow: leveraging reef-scale hydrodynamics for upscaling larval-based restoration |
| 蚊翅图像库：推进基于几何形态计量学和人工智能识别的研究 |
Nolte, K. |
PDF |
N/A |
Mosquito Wing Image Repository for Advancing Research on Geometric Morphometric- and AI-Based Identification |
| 更新世海平面波动塑造了濒危的洛德豪岛蟑螂（Panesthia lata）在整个群岛范围内的种群结构。 |
Adams, M. W. D. |
PDF |
N/A |
Pleistocene sea-level fluctuation shapes archipelago-wide population structure in the Endangered Lord Howe Island cockroach Panesthia lata |
| 首次为三种海葵（珊瑚纲：海葵目）宿主的克隆鱼物种生成了从头HiFi基因组组装 |
De Jode, A. |
PDF |
N/A |
The first de novo HiFi genome assemblies for three clownfish-hosting sea anemone species (Anthozoa: Actiniaria) |
| 具有自体组织驻留巨噬细胞的人类心脏类器官再现了生理性的免疫-心脏相互作用 |
O'Hern, C. |
PDF |
N/A |
Human heart assembloids with autologous tissue-resident macrophages recreate physiological immuno-cardiac interactions |
| 在临床质子治疗系统的同步回旋加速器室内，对A549肺癌细胞和IMR90健康人成纤维细胞进行体外FLASH辐照。 |
Zazpe, A. |
PDF |
N/A |
In vitro FLASH irradiation of A549 lung cancer cells and IMR90 healthy human fibroblasts in the synchrocyclotron room of a clinical proton therapy system |
| 用于狨猴神经科学设备的开放获取资源 |
Rollin, I. Z. |
PDF |
N/A |
An Open Access Resource for Marmoset Neuroscientific Apparatus |
| 使用CryFold改进冷冻电镜图的自动化模型构建 |
Su, B. |
PDF |
N/A |
Improved automated model building for cryo-EM maps using CryFold |
| scCompass：一个集成的跨物种单细胞RNA测序数据库，为AI准备就绪 |
Wang, P. |
PDF |
N/A |
scCompass: An integrated cross-species scRNA-seq database for AI-ready |
| 无膜细胞器的蛋白质稳态网络的组织 |
Lim, C. M. |
PDF |
N/A |
Organization of the Proteostasis Network of Membraneless Organelles |
| 超快弹性毛细管风扇控制波纹虫和机器人的敏捷机动 |
Ortega-Jimenez, V. |
PDF |
N/A |
Ultrafast elastocapillary fans control agile maneuvering in ripple bugs and robots |
| 动态捕获的凝聚融合创造出具有不同材料特性的复杂结构 |
Erkamp, N. A. |
PDF |
N/A |
Dynamically arrested condensate fusion creates complex structures with varying material properties |
| 由雄激素受体转录激活域与小分子药物形成共价加合物后仍保持无序状态。 |
Zhu, J. |
PDF |
N/A |
Covalent adducts formed by the androgen receptor transactivation domain and small molecule drugs remain disordered |
| 癌症相关突变对聚腺苷二磷酸核糖聚合酶1抑制作用的影响 |
Shanmugam, N. |
PDF |
N/A |
Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition |
| MR-ARFI在人体经颅聚焦超声中的优化 |
Mohammadjavadi, M. |
PDF |
N/A |
Optimization of MR-ARFI for Human Transcranial Focused Ultrasound |
| 起源的基底细胞解决了癌症中神经内分泌-丛状谱系可塑性 |
Ireland, A. S. |
PDF |
N/A |
Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer |
| 基于逻辑的机器学习预测艾司西酞普兰如何抑制心肌细胞肥大 |
Eggertsen, T. G. |
PDF |
N/A |
Logic-based machine learning predicts how escitalopram inhibits cardiomyocyte hypertrophy |
| 无偏倚地发现能够刺激巨噬细胞介导的B细胞淋巴瘤破坏的抗体疗法 |
Ribeiro, J. |
PDF |
N/A |
Unbiased discovery of antibody therapies that stimulate macrophage-mediated destruction of B-cell lymphoma |
| 酪蛋白2A2通过增强免疫突触内CD45磷酸酶活性促进T细胞免疫调节 |
Ali, S. |
PDF |
N/A |
Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse |
| RecN和RecA在埃希氏大肠杆菌中协调了环丙沙星暴露后有序的DNA超压缩反应。 |
Vikedal, K. |
PDF |
N/A |
RecN and RecA orchestrate an ordered DNA supercompaction response following ciprofloxacin exposure in Escherichia coli |
| 一种快速、经济高效的高产DNA从PCR产物和琼脂糖凝胶中纯化的方法。 |
Fatima, S. |
PDF |
N/A |
A Rapid, Cost-Effective Method for High-Yield DNA Purification from PCR Products and Agarose Gels. |
| 解密金黄色葡萄球菌中含Com_YlbF结构域蛋白质的功能。 |
Rozo, Z. L. C. |
PDF |
N/A |
Deciphering the function of Com_YlbF domain-containing proteins in Staphylococcus aureus. |
| Sla2 是网格蛋白轻链与 Pan1/End3/Sla1 复合体之间的核心相互作用枢纽。 |
Draper-Barr, G. |
PDF |
N/A |
Sla2 is a core interaction hub for Clathrin Light Chain and the Pan1/End3/Sla1Complex |
| 急性呼吸窘迫综合征肺部细胞外基质的组成变化 |
Fan, Y. |
PDF |
N/A |
Compositional changes of the lung extracellular matrix in acute respiratory distress syndrome |
| 将纳米孔MinION测序整合到国家动物健康抗菌素耐药性监测计划中：一项关于印尼鸡肉屠宰场废水和河流的试点研究 |
Telussa, R. |
PDF |
N/A |
Integrating Nanopore MinION Sequencing into National Animal Health AMR Surveillance Programs: An Indonesian Pilot Study of Chicken Slaughterhouse Effluent and Rivers |
| 利用绿色和近红外荧光蛋白的荧光交叉相关光谱技术，在活细胞中定量测定细胞周期蛋白-CDK的解离常数。 |
Toyama, A. |
PDF |
N/A |
Quantification of Cyclin-CDK dissociation constants in living cells using fluorescence cross-correlation spectroscopy with green and near-infrared fluorescent proteins. |
| 揭示珊瑚礁的普遍空间特性 |
Gimenez-Romero, A. |
PDF |
N/A |
Unravelling the universal spatial properties of coral reefs |
| 在珊瑚Montipora capitata中，遮蔽不会降低其热耐受性：对保护干预的启示 |
Ducret, H. |
PDF |
N/A |
Shading does not lower thermal tolerance in the coral Montipora capitata: implications for conservation intervention |
| 减去误差：在存在残留对齐错误的情况下估计dN/dS并测试自然选择 |
Selberg, A. |
PDF |
N/A |
Minus the Error: Estimating dN/dS and Testing for Natural Selection in the Presence of Residual Alignment Errors |
| 蜥蜴和喙头蜥（鳞龙类）中松果体非视觉视蛋白的演化 |
Romero, R. D. |
PDF |
N/A |
Evolution of pineal non-visual opsins in lizards and the tuatara (Lepidosauria) |
| 重新定义性传播寄生虫阴道毛滴虫及其在鸽形目鸟类中的近缘物种的剪接体内含子 |
Callejas-Hernandez, F. |
PDF |
N/A |
Redefining the spliceosomal introns of the sexually transmitted parasite Trichomonas vaginalis and its close relatives in columbid birds |
| 使用Takoyaki超声技术对深层组织中的细胞和分子进行实时体积成像 |
Lee, S. |
PDF |
N/A |
Real-time volumetric imaging of cells and molecules in deep tissues with Takoyaki ultrasound |
| 常见的AAV基因治疗载体表现出对活体人脑细胞类型的无差别转导 |
McGinnis, J. |
PDF |
N/A |
Common AAV gene therapy vectors show indiscriminate transduction of living human brain cell types |
| 优化VSV G骨架以实现与纳米抗体的氨基端融合，使其能够重新定向至治疗相关受体的受体。 |
Duquenois, I. |
PDF |
N/A |
Optimization of the VSV G backbone for amino terminal fusion with nanobodies allowing its retargeting to receptors of therapeutic interest. |
| 用于血友病B的通用碱基编辑 |
Baatartsogt, N. |
PDF |
N/A |
Universal base editing for hemophilia B |
| 高适应度路径可以连接序列重叠度低的蛋白质 |
Kantroo, P. |
PDF |
N/A |
High fitness paths can connect proteins with low sequence overlap |
| 从知识库、注册表和多组学数据生成生物医学知识图谱 |
Qin, G. |
PDF |
N/A |
Generating Biomedical Knowledge Graphs from Knowledge Bases, Registries, and Multiomic Data |
| 在优化后的Colab处理器上对GROMACS进行基准测试，以及云计算在分子动力学中的灵活性 |
Karagöl, T. |
PDF |
N/A |
Benchmarking GROMACS on Optimized Colab Processors and the Flexibility of Cloud Computing for Molecular Dynamics |
| DDA-BERT：利用基于数据依赖采集质谱的蛋白质组学中的Transformer架构预训练 |
A, J. |
PDF |
N/A |
DDA-BERT: leveraging transformer architecture pre-training for data-dependent acquisition mass spectrometry-based proteomics |
| 用于预测病毒-人类蛋白质相互作用的机器学习方法：对逆转录病毒相互作用网络的评估 |
Mahmoudi, O. |
PDF |
N/A |
Machine Learning Approaches for Predicting Virus-Human Protein-Protein Interactions: An Evaluation of Retroviral Interaction Networks |
| 一种用于从头设计抗菌肽的多属性优化生成对抗网络 |
Liu, J. |
PDF |
N/A |
A Multi-Property Optimizing Generative Adversarial Network for de novo Antimicrobial Peptide Design |
| 使用PhenoGeneRanker识别与阿尔茨海默病相关的基因 |
Rahman, M. T. |
PDF |
N/A |
Identifying Alzheimer's disease-associated genes using PhenoGeneRanker |
| 原子基本通量模式解释了大规模通量网络中代谢物的稳态流动 |
Chitpin, J. G. |
PDF |
N/A |
Atomic elementary flux modes explain the steady state flow of metabolites in large-scale flux networks |
| 脂质包装缺陷是α-突触核蛋白膜结合的必要且充分条件 |
Johnson, D. H. |
PDF |
N/A |
Lipid Packing Defects are Necessary and Sufficient for Membrane Binding of alpha-Synuclein |
| 人类线粒体复制解旋酶的实时动力学自动调节 |
Plaza G-A, I. |
PDF |
N/A |
Auto-regulation of the real-time kinetics of the human mitochondrial replicative helicase |
| 通过不对称纳米孔解析电流整流 |
Lin, Y. |
PDF |
N/A |
Dissecting current rectification through asymmetric nanopores |
| 利用染色质包装域在体内靶向化疗逃逸 |
Frederick, J. |
PDF |
N/A |
Leveraging chromatin packing domains to target chemoevasion in vivo |
| 空间排斥抵消了ER到脂滴的蛋白质运动 |
Damm, A. |
PDF |
N/A |
Steric Repulsion Counteracts ER-to-Lipid Droplet Protein Movement |
| 一个稳健的计算框架，用于优化CDK7抑制剂作为有前景的癌症疗法 |
Shi, Z. |
PDF |
N/A |
A Robust Computational Framework for the Optimization of CDK7 Inhibitors as Promising Cancer Therapy |
| 糖皮质激素受体凝聚物在转录调控中的标志 |
Benitez, B. |
PDF |
N/A |
Hallmarks of glucocorticoid receptor condensates involvement in transcription regulation |
| C1C2通道视紫红质开启机制的结构见解 |
Mulder, M. |
PDF |
N/A |
Structural insights into the opening mechanism of C1C2 channelrhodopsin |
| 波形蛋白中的单一半胱氨酸残基通过调控长链非编码RNA XIST，抑制乳腺癌中的上皮-间质转化及干细胞特性 |
Usman, S. |
PDF |
N/A |
A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial-mesenchymal transition and stemness in breast cancer |
| 代谢重编程与染料木黄酮和化疗在人乳腺癌细胞中的协同细胞毒性 |
Tobon-Cornejo, S. |
PDF |
N/A |
Metabolic reprogramming and synergistic cytotoxicity of genistein and chemotherapy in human breast cancer cells |
| 5q缺失型急性髓系白血病是一种表观遗传学上独特的亚群，其特征是KDM3B的杂合性缺失。 |
Kelly, K. |
PDF |
N/A |
Acute Myeloid Leukemia with deletion 5q is an epigenetically distinct subgroup defined by heterozygous loss of KDM3B |
| 古生态系统的选择、演化和持久性 |
Roopnarine, P. D. |
PDF |
N/A |
Selection, Evolution and Persistence of Paleoecological Systems |
| 表观遗传调节NLRP6炎症小体传感器作为一种治疗手段，以减少HIV/SIV感染中由坏死性凋亡驱动的胃肠道黏膜功能障碍 |
Premadasa, L. S. |
PDF |
N/A |
Epigenetic modulation of NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection |
| 激素诱导的血栓形成是通过非经典的纤维蛋白（原）聚集和斑马鱼中一种新的雌激素靶点介导的。 |
Yu, X. |
PDF |
N/A |
Hormone-induced thrombosis is mediated through non-canonical fibrin(ogen) aggregation and a novel estrogen target in zebrafish |
| 全动物表型药物筛选鉴定出抑制动脉粥样硬化脂蛋白的药物。 |
Kelpsch, D. J. |
PDF |
N/A |
A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins. |
| 量化环境传播和年龄特异性易感性的关键参数，针对鸟分枝杆菌副结核亚种（MAP） |
Gao, Y. |
PDF |
N/A |
Quantifying Key Parameters of Environmental Transmission and Age-Specific Susceptibility for Mycobacterium avium subspecies paratuberculosis (MAP) |
| 饮食限制增强CD8+ T细胞酮体代谢以限制衰竭并提升抗肿瘤免疫 |
Oswald, B. M. |
PDF |
N/A |
Dietary Restriction Enhances CD8+ T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity |
| 新发现的鼠CD103-树突状细胞是高度免疫活性的常规DC2亚群，与已知的鼠和人类树突状细胞亚群相对应。 |
Sawanobori, Y. |
PDF |
N/A |
Newly found rat CD103- dendritic cells are the highly immunogenic conventional DC2 subpopulation, corresponding to the known DC subsets in mice and humans. |
| 伴随文章：《嗜酸性食管炎中牛奶过敏原免疫识别的分子基础》 |
Dilollo, J. |
PDF |
N/A |
Companion to: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis |
| 利用核糖体图谱技术揭示新型保守的HIV-1开放阅读框，编码T细胞抗原。 |
Bertrand, L. |
PDF |
N/A |
Unveiling novel conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling. |
| 揭示流感A病毒中的重配现象：TreeSort的应用 |
Markin, A. |
PDF |
N/A |
Revealing reassortment in influenza A viruses with TreeSort |
| 多层次的生态相互作用决定了临床耐药菌株在人类微生物群中的生长 |
Leon-Sampedro, R. |
PDF |
N/A |
Multi-layered ecological interactions determine growth of clinical antibiotic-resistant strains within human microbiomes |
| 温度调节疟蚊共生体微孢子虫MB的传播潜力，该共生体可阻断疟疾传播 |
Otieno, F. G. |
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N/A |
Temperature modulates the dissemination potential of Microsporidia MB, a malaria-blocking endosymbiont of Anopheles mosquitoes |
| 利用包膜二聚体开发蜱传脑炎病毒纳米颗粒疫苗 |
Wang, B. |
PDF |
N/A |
Development of a tick-borne encephalitis virus nanoparticle vaccine utilizing envelope dimer |
| 促炎通路在小鼠模型中参与艰难梭菌感染的发病机制——一项空间转录组学研究 |
Ghahari, N. |
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N/A |
Pro-inflammatory Pathways Contribute to Pathogenesis of Clostridioides difficile Infection in a Murine Model - A Spatial Transcriptomics Study |
| 探索人类TSG101的UEV结构域的药物潜力，以寻找广谱抗病毒药物 |
Montero, F. |
PDF |
N/A |
Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrum antivirals |
| KPC-14的特性：一种KPC变异体，赋予广泛耐药的ST463铜绿假单胞菌临床分离株对头孢他啶-阿维巴坦的耐药性 |
Xiao, Y. |
PDF |
N/A |
Characteristic of KPC-14, a KPC Variant Conferring Resistance to Ceftazidime-Avibactam in the Extensively Drug-resistant ST463 Pseudomonas aeruginosa Clinical Isolate |
| 通过基于原位荧光杂交的光学筛选鉴定ALT途径的新型调节因子 |
Azeroglu, B. |
PDF |
N/A |
Identification of Novel Modulators of the ALT Pathway Through a Native FISH-Based Optical Screen |
| autoFISH - 一个用于连续单分子荧光原位杂交实验的模块化工具箱 |
Weber, C. |
PDF |
N/A |
autoFISH - a modular toolbox for sequential smFISH experiments |
| 外泌体中miRNAs分选的负调控：RNA结合蛋白PCBP2损害SYNCRIP介导的miRNAs外泌体装载 |
Marocco, F. |
PDF |
N/A |
Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading |
| 排斥性客户关机在Yb体内的短暂寄居在Piwi-piRISC生物发生和维持生育能力中起着关键作用。 |
Hirakata, S. |
PDF |
N/A |
Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility |
| ATR保护复制叉免受APOBEC3B诱导的有害PARP1捕获的影响 |
Ortega, P. |
PDF |
N/A |
ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping |
| 恢复PKM1通过调节PEP代谢改善人干细胞衍生的β细胞的功能成熟 |
Lin, H. |
PDF |
N/A |
Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism |
| 顶复门DedA超家族蛋白VMP1对于分泌器官的生物发生和功能至关重要 |
Reddy, G. S. |
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N/A |
The apicomplexan DedA superfamily protein VMP1 is crucial for the biogenesis and function of secretory organelles |
| Jagged1是一种在血管内皮细胞中独立于Notch的机械转导因子。 |
Suarez Rodriguez, F. |
PDF |
N/A |
Jagged1 is a Notch-independent mechanotransducer in endothelial cells |
| 通过体表碳氢化合物识别合适交配伴侣——一种具有极端同性二态性的物种 |
Moris, V. C. |
PDF |
N/A |
Recognition of an appropriate mating partner using cuticular hydrocarbons in a species with an extreme intra-sexual dimorphism |
| 吸引猎物但不被捕食者排斥表明在遭遇-躲避-逃脱序列中存在不对称的投资。 |
Ferry, N. |
PDF |
N/A |
Prey attracting but not repelled by predators suggests an asymmetric investment in the encounter-avoid-escape sequence. |
| 从恐惧到盛宴：响尾蛇在恐惧的景观中导航以优化觅食 |
Da Cunha, O. |
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N/A |
FROM FEAR TO FEAST: RATTLESNAKES NAVIGATE THE LANDSCAPE OF FEAR TO OPTIMIZE FORAGING |
| 恢复的生物标志物：生态修复后营养流动的特征化 |
Spindel, N. B. |
PDF |
N/A |
Biomarkers of recovery: characterizing trophic flow following ecological restoration |
| 大象应该吃草还是吃树叶？杂食性巨型草食动物饮食变化的养分和功能后果 |
Gautam, H. |
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N/A |
Should elephants graze or browse? The nutritional and functional consequences of dietary variation in a mixed-feeding megaherbivore |
| 来自较高羊膜动物的CGGBP1限制胞嘧啶甲基化，并在被抑制的启动子处驱动转录因子结合位点的GC偏向性 |
Kumar, P. |
PDF |
N/A |
CGGBP1 from higher amniotes restricts cytosine methylation and drives a GC-bias in transcription factor binding sites at repressed promoters |
| 扩展的“共同原因”：间断进化与沉积过程之间的因果联系 |
Polly, P. D. |
PDF |
N/A |
The extended 'common cause': causal links between punctuated evolution and sedimentary processes |
| 三刺鱼中的新生突变率 |
Zhang, C. |
PDF |
N/A |
Rate of de novo mutations in the three-spined stickleback |
| 热带岛屿特有鸟类的种群数量对气候的响应受到栖息地可用性和物种特性的调节。 |
Karjee, R. |
PDF |
N/A |
Tropical island endemic birds' demographic responses to climate are modulated by habitat availability and species traits |
| 通过连续不对称减数分裂实现的自我抑制性染色体驱动 |
Meng, X. |
PDF |
N/A |
Self-restrained sex chromosome drive through sequential asymmetric meiosis |
| 结合功能注释和多性状精细定位方法可提高血糖性状位点的精细定位分辨率 |
Soenksen, J. |
PDF |
N/A |
Combining functional annotation and multi-trait fine-mapping methods improves fine-mapping resolution at glycaemic trait loci |
| 在生物实验中使用逻辑回归和Cochran-Mantel-Haenszel检验对分类数据进行分析 |
Androwski, R. J. |
PDF |
N/A |
Analysis of Categorical Data with Logistic Regression and the Cochran-Mantel-Haenszel Tests in Biological Experiments |
| 苦味基因与口腔健康：加拿大老龄化纵向研究 |
Shafizadeh, M. |
PDF |
N/A |
Bitter taste genetics and oral health in Canadian Longitudinal Study on Aging |
| 多视角最佳线性无偏预测（Multi-view BLUP）：一种有前景的后组学数据整合预测方法 |
Wu, B. |
PDF |
N/A |
Multi-view BLUP: a promising solution for post-omics data integrative prediction |
| 端粒重复序列含RNA在老化的人类细胞中增加 |
Chu, H.-P. C. |
PDF |
N/A |
Telomeric Repeat-Containing RNA Increases in Aged Human Cells |
| CUT&RUN峰值调用方法的基准测试 |
Nooranikhojasteh, A. |
PDF |
N/A |
Benchmarking Peak Calling Methods for CUT&RUN |
| 对PeptideAtlas数据库的深入审计揭示了未注释编码基因和异常翻译的证据。 |
Rodriguez, J. M. |
PDF |
N/A |
A deep audit of the PeptideAtlas database uncovers evidence for unannotated coding genes and aberrant translation |
| DNA拓扑异构酶Top2的减少能够重新编程表观遗传景观，并在多个物种中延长健康和寿命。 |
Zhu, M. |
PDF |
N/A |
Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species |
| 来自L. meyenii Walp的脂质纳米颗粒通过多模态蛋白质冠形成减轻脓毒症 |
Sung, J. J. |
PDF |
N/A |
Lipid Nanoparticles from L. meyenii Walp Mitigate Sepsis through Multimodal Protein Corona Formation |
| 预测喉镜图像中的语义分割质量 |
Kist, A. M. |
PDF |
N/A |
Predicting semantic segmentation quality in laryngeal endoscopy images |
| 体积成像与计算技术在斑马鱼心脏收缩功能研究中的应用 |
Saberigarakani, A. |
PDF |
N/A |
Volumetric imaging and computation to explore contractile function in zebrafish hearts |
| 非角化颊部组织在负压冲击下的有限元模型 |
Klein Cerrejon, D. |
PDF |
N/A |
Finite element model of the non-keratinized buccal tissue under the impact of negative pressure |
| SMAC：利用SMRT CCS数据在单分子水平上鉴定DNA N6-甲基腺苷（6mA） |
Li, H. |
PDF |
N/A |
SMAC: identifying DNA N6-methyladenine (6mA) at the single-molecule level using SMRT CCS data |
| InterPLM：通过稀疏自编码器在蛋白质语言模型中发现可解释的特征 |
Simon, E. |
PDF |
N/A |
InterPLM: Discovering Interpretable Features in Protein Language Models via Sparse Autoencoders |
| 利用蛋白质语言模型对蛋白质-肽结合亲和力进行排序 |
Chalas, C. C. |
PDF |
N/A |
Ranking protein-peptide binding affinities with protein language models |
| 解密姜黄素对乳腺癌中组蛋白标记的表观遗传影响：基于3D网络的研究 |
Tang, T. |
PDF |
N/A |
Deciphering epigenetic influence of curcumin on histone signatures in breast cancer using 3D network |
| Fast-Part：用于生物序列分析的快速且准确的数据分区工具 |
Ahmed, S. |
PDF |
N/A |
Fast-Part: Fast and Accurate Data Partitioning for Biological Sequence Analysis |
| 评估肺炎链球菌中假定小RNA的保守性和目标 |
Eichelman, M. C. |
PDF |
N/A |
Assessing the conservation and targets of putative sRNAs in Streptococcus pneumoniae |
| IMMClock揭示了免疫老化和T细胞功能在单细胞分辨率下的表现 |
Schmidt, Y. G. |
PDF |
N/A |
IMMClock reveals immune aging and T cell function at single-cell resolution |
| 大规模定量交联与质谱技术为细胞器、细胞和组织内的蛋白质构象可塑性提供了新的见解 |
Keller, A. |
PDF |
N/A |
Large-Scale Quantitative Cross-Linking and Mass Spectrometry Provides New Insight on Protein Conformational Plasticity within Organelles, Cells, and Tissues |
| NERVE 2.0：通过人工智能和用户友好的网络界面提升新增强反向疫苗学环境 |
Conte, A. |
PDF |
N/A |
NERVE 2.0: boosting the New Enhanced Reverse Vaccinology Environment via artificial intelligence and a user-friendly web interface |
| 使用InMoose进行差异表达分析，InMoose是Python中的集成多组学开源环境 |
Colange, M. |
PDF |
N/A |
Differential Expression Analysis with InMoose, the Integrated Multi-Omic Open-Source Environment in Python |
| 通过X射线散射和坐标建模对细菌微区室壳体的结构表征：细胞质蛋白偶然捕获的证据 |
Zuo, X. |
PDF |
N/A |
Structure Characterization of Bacterial Microcompartment Shells via X-ray Scattering and Coordinate Modeling: Evidence for adventitious capture of cytoplasmic proteins |
| 肿瘤球体对荧光纳米金刚石的摄取受限于质量密度：一种四维光片检测法 |
Niora, M. |
PDF |
N/A |
Tumor Spheroid Uptake of Fluorescent Nanodiamonds is Limited by Mass Density: a 4D Light-Sheet Assay |
| 在三维空间中量化单个纤维尺度的细胞牵引力：基于可变形光聚合纤维阵列的新方法 |
Ucla, P. |
PDF |
N/A |
Quantifying Cell Traction Forces at the Individual Fiber Scale in 3D: A Novel Approach Based on Deformable Photopolymerized Fiber Arrays |
| 全片基质成像显示，密集纤维基质是II期结肠癌复发的高风险因素 |
Ravensbergen, C. |
PDF |
N/A |
Whole-Slide ECM Imaging Reveals Dense Fibrous Matrix as a High-Risk Factor for Recurrence in Stage II Colon Cancer |
| 发育阶段与细胞背景决定Ezh2Y641F突变在造血中的致癌与分子结果 |
Zimmerman, S. M. |
PDF |
N/A |
Developmental Stage and Cellular Context Determine Oncogenic and Molecular Outcomes of Ezh2Y641F Mutation in Hematopoiesis |
| 癌症细胞中p53对SOX2的转录抑制调控细胞身份和迁移 |
Lado-Fernandez, P. |
PDF |
N/A |
Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration |
| ecPath 通过组织病理学图像检测肿瘤中的ecDNA |
Choudhury, M. |
PDF |
N/A |
ecPath detects ecDNA in tumors from histopathology images |
| 鉴定Ephrin B型受体4为组织纤维化的关键介质 |
Wu, B. R.-L. |
PDF |
N/A |
Identification of Ephrin type-B receptor 4 as a critical mediator of tissue fibrosis |
| 成纤维细胞衍生的骨糖蛋白促进上皮细胞修复 |
van der Koog, L. |
PDF |
N/A |
Fibroblast-derived osteoglycin promotes epithelial cell repair |
| 腓肠肌俯卧撑对糖尿病前期患者血糖耐受性的影响 |
Elek, D. |
PDF |
N/A |
The effects of soleus push up on glucose tolerance among individuals with prediabetes |
| 源自生物衰老组织学特征的组织时钟能够从血液中进行组织特异性衰老预测 |
Abila, E. |
PDF |
N/A |
Tissue clocks derived from histological signatures of biological aging enable tissue-specific aging predictions from blood |
| OPN5和TRPV4在小鼠角膜上皮的内源性光敏感性中起作用。 |
Lapajne, L. |
PDF |
N/A |
OPN5 and TRPV4 subserve intrinsic photosensitivity in mouse corneal epithelium |
| 对哺乳动物分泌途径的重建揭示了调控抗体生产的机制 |
Masson, H. |
PDF |
N/A |
A reconstruction of the mammalian secretory pathway identifies mechanisms regulating antibody production |
| 一种新颖而简单的操作方法大大提高了大鼠肝脏移植的成功率。 |
Chen, Y. |
PDF |
N/A |
A novel and simple maneuver greatly improves rat liver transplantation |
| 单细胞图谱的描绘为川崎病冠状动脉病变的发展提供了新的见解：坏与好的信号分子 |
Lin, Q. |
PDF |
N/A |
Delineation of Single-cell Altas Provides New Insights for Development of Coronary Artery Lesions in Kawasaki Disease: Bad and Good Signaling Molecules |
| 规范的Notch2信号调节铁回收巨噬细胞的发育和铁稳态 |
Schroth, F. N. |
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Canonical Notch2 Signaling Regulates the Development of Iron-recycling Macrophages and Iron Homeostasis |
| 木制奶酪熟化板上的微生物群是产生抗李斯特菌单核细胞增生菌的抗菌细菌的丰富来源。 |
Chen, Y. |
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The microbiota of wooden cheese ripening boards is a rich source of antimicrobial-producing bacteria against Listeria monocytogenes |
| 综合蛋白质组和脂质组分析将OCIAD1定位于线粒体与过氧化物酶体的交汇处，平衡脂质代谢 |
Linke, V. |
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Integrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism |
| 抑制酸性神经酰胺酶作为一种治疗尼曼-皮克C病的治疗策略 |
Haynes, I. |
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N/A |
Inhibition of acid ceramidase as a therapeutic strategy for Niemann-Pick C disease |
| 通过两亲性螺旋在内核膜上感知脂质松动的参数 |
Lee, S. |
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N/A |
Parameters for sensing lipid loosening at the inner nuclear membrane by amphipathic helices |
| 在颗石藻生物矿化过程中富钙区室的动态变化 |
Triccas, A. |
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N/A |
Dynamic change of calcium-rich compartments during coccolithophore biomineralization |
| ATF4通过调节线粒体功能障碍、线粒体自噬和自噬，在Fuchs营养不良症中慢性内质网应激下促进角膜内皮细胞凋亡。 |
Qureshi, S. |
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N/A |
ATF4 regulates mitochondrial dysfunction, mitophagy, and autophagy, contributing to corneal endothelial apoptosis under chronic ER stress in Fuchs dystrophy |
| TUDCA通过调节药物生物利用度来调控酿酒酵母对急性内质网应激的抗性 |
Chadwick, S. R. |
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N/A |
TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae |
| PCMD-1稳定了PCM支架并促进了中心粒的分离 |
Schreiner, A. |
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PCMD-1 stabilizes the PCM scaffold and facilitates centriole separation |
| 人工结构中优化的凹槽设计显著提高了珊瑚的定居和生存率 |
Reichert, J. |
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Optimized recess design in artificial structures dramatically enhances coral settlement and survival |
| 评估数据驱动的捕食者-猎物模型的保真度：动力系统分析 |
Frank, A.-S. |
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Evaluating the Fidelity of Data-Driven Predator-Prey Models: A Dynamical Systems Analysis |
| 时间至关重要：H5N1病毒在奶牛场的控制效果受限于其快速传播。 |
DeWitt, M. E. |
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Time is of the essence: effectiveness of dairy farm control of H5N1 is limited by fast spread |
| 探索珠穆朗玛峰绒布河流域冰川补给河流沉积物中的产甲烷古菌及其热响应 |
Ma, W. |
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Exploring methanogenic archaea and their thermal responses in the glacier-fed stream sediments of Rongbuk River Basin, Mt. Everest |
| 澳大利亚无刺蜜蜂的视觉生理学 |
Penmetcha, B. |
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N/A |
Visual physiology of Australian stingless bees |
| 泛癌种有丝分裂DNA完整性检验点蛋白激酶的遗传特征 |
Rasteh, A. M. |
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Pan-Cancer Genetic Profiles of Mitotic DNA Integrity Checkpoint Protein Kinases |
| LIN-35和DREAM复合体促进温度应激诱导的秀丽隐杆线虫生殖细胞凋亡和胞质流动增加。 |
Petrella, L. N. |
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N/A |
LIN-35 and the DREAM complex promote temperature stress induced increases in germline apoptosis and cytoplasmic streaming in C. elegans |
| 类固醇受体辅助加载调控前列腺癌细胞的转录反应 |
Hiltunen, J. |
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Steroid receptor-assisted loading modulates transcriptional responses in prostate cancer cells |
| 不确定性感知基因组深度学习与知识蒸馏 |
Zhou, J. |
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Uncertainty-aware genomic deep learning with knowledge distillation |
| Illumina Complete Long Read Ass测定法能够从人类肠道宏基因组中生成连续的细菌基因组。 |
Maghini, D. G. |
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Illumina Complete Long Read Assay yields contiguous bacterial genomes from human gut metagenomes |
| 可点击的聚乙二醇-降冰片烯微凝胶支持悬浮生物打印和微血管组装 |
Zhang, I. W. |
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Clickable PEG-norbornene microgels support suspension bioprinting and microvascular assembly |
| 利用蛋白质结构图嵌入预测错义变异的致病性 |
Danner, M. |
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N/A |
Utilizing protein structure graph embeddings to predict the pathogenicity of missense variants |
| 使用穷尽蛋白质搜索和Alphafold2进行蛋白质搜索漂移的特征化 |
Buchan, D. W. |
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Characterising Protein Search Drift using exhaustive protein search and Alphafold2 |
| miRBench：一个全面的微RNA结合位点预测训练和基准测试数据集 |
Sammut, S. |
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miRBench: A Comprehensive microRNA Binding Site Prediction Training and Benchmarking Dataset |
| 阿努比斯：一种利用随机森林分类法对古代蛋白质进行多层次鉴定的方法 |
Chiang, Y. |
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Anubis: a multi-level authentication scale for ancient proteins using random forest classification |
| STABIX：基于摘要统计的全基因组关联分析索引与压缩 |
Schneider, K. |
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N/A |
STABIX: Summary statistic-based GWAS indexing and compression |
| TSniffer：在RNA-seq数据中无偏倚地从头鉴定RNA编辑位点并量化编辑活性 |
Herrmann, M. |
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TSniffer: Unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data |
| 语言模型引导的未知代谢物预测与发现 |
Qiang, H. |
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N/A |
Language model-guided anticipation and discovery of unknown metabolites |
| CLUEY 能够从单细胞组学数据中实现知识引导的聚类和细胞类型检测。 |
Kim, D. |
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CLUEY enables knowledge-guided clustering and cell type detection from single-cell omics data |
| 构建基于单细胞转录组的坐标系统用于细胞ID识别的SURE方法 |
Zeng, F. |
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Building a single cell transcriptome-based coordinate system for cell ID with SURE |
| 脂质组成在体外和体内系统之间的铁死亡敏感性上存在差异 |
Park, V. S. |
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Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems |
| 过氧化物酶表达在肿瘤内毛细血管和邻近透明细胞肾细胞癌的近端小管细胞中增加。 |
Pestana e Silva, R. N. |
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Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma. |
| 司美格鲁肽诱导的体重减轻改善了骨骼肌线粒体能量效率 |
Choi, R. H. |
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Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle |
| 数字免疫优化血凝素与纳米笼插接展示技术激发广泛中和的全H5流感亚型疫苗反应 |
Huang, C. Q. |
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Digitally immune optimised haemagglutinin with nanocage plug-and-display elicits broadly neutralising pan-H5 influenza subtype vaccine responses |
| 抗HIV-1 B细胞抗原受体信号传导与结构 |
Thakur, B. |
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Anti-HIV-1 B cell antigen receptor signaling and structure |
| 炎症相关单核细胞表达ACOD1以遏制炎症行为在IBD和实验性结肠炎中 |
Jones, G.-R. |
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Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis |
| 血吸虫食道腺因子MEG-8.2驱动宿主细胞裂解并与其免疫蛋白相互作用 |
Yadav, P. |
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N/A |
Schistosome esophageal gland factor MEG-8.2 drives host cell lysis and interacts with host immune proteins |
| 衣原体质粒编码蛋白Pgp2是一种复制起始蛋白，具有独特的β-发夹结构，对于与迭代子结合及质粒复制至关重要。 |
Wan, D. |
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N/A |
Chlamydia plasmid-encoded protein Pgp2 is a replication initiator with a unique beta-hairpin necessary for iteron-binding and plasmid replication |
| 利用蛋白质语言模型进行基于结构的发现，以获得高效且稳定的PET水解酶 |
Wu, B. |
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N/A |
Harnessing Protein Language Model for Structure-Based Discovery of Highly Efficient and Robust PET Hydrolases |
| 新型CRITR-seq方法揭示了流感转录受到NELF的调控，并且是引发干扰素反应的关键事件。 |
Vicary, A. C. |
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N/A |
Novel CRITR-seq approach reveals influenza transcription is modulated by NELF and is a key event precipitating an interferon response |
| 维生素E、高密度脂蛋白及B型1类清道夫受体对脂质氧化与铁死亡的生理调节作用 |
Rink, J. S. |
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Physiologic Regulation of Lipid Oxidation and Ferroptosis By Vitamin E, High-Density Lipoprotein, and Scavenger Receptor Class B Type 1 |
| 一类新型变构葡萄糖脑苷脂酶β1校正剂，可减轻细胞应激并增强溶酶体功能 |
Fregno, I. |
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N/A |
A novel class of allosteric glucosylceramidase beta 1 correctors that reduce cellular stress and enhance lysosomal function |
| 城市树木多样性促进了鸟类食虫性，尽管随着城市化进程，鸟类多样性有所下降。 |
Schille, L. |
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N/A |
Urban tree diversity fosters bird insectivory despite a loss in bird diversity with urbanization |
| 区分果蝇中轻度、重度及非典型过氧化物酶体生成障碍的PEX基因变异严重程度 |
Gomez, V. A. |
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N/A |
Distinguishing PEX gene variant severity for mild, severe, and atypical peroxisome biogenesis disorders in Drosophila |
| PRC1和CTCF介导的从预备状态到活跃状态的染色质环转变驱动双价基因激活 |
Hanafiah, A. |
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N/A |
PRC1 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation |
| mTORC1在溶酶体膜上整合生长因子和营养信号的结构基础 |
Cui, Z. |
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N/A |
Structural basis for growth factor and nutrient signal integration on the lysosomal membrane by mTORC1 |
| 受缺陷的SNARE拉链或硬质脂质脂肪酸组成限制的膜融合反应对Sec17、Sec18和腺苷酸有不同的需求。 |
Lopes, K. |
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Membrane fusion reactions limited by defective SNARE zippering or stiff lipid fatty acyl composition have distinct requirements for Sec17, Sec18, and adenine nucleotide |
| 炎症巨噬细胞分泌的细胞因子调节了水凝胶生物材料上瓣膜间质细胞的性别差异 |
Felix Velez, N. E. |
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N/A |
Secreted cytokines from inflammatory macrophages modulate sex differences in valvular interstitial cells on hydrogel biomaterials |
| Orthrus：一种基于人工智能、云端就绪且开源的混合方法，用于元蛋白质组学研究 |
Chiang, Y. |
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N/A |
Orthrus: an AI-powered, cloud-ready, and open-source hybrid approach for metaproteomics |
| 从Hi-C数据解读跨物种的三维基因组结构 |
Shkolikov, A. |
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N/A |
Deciphering the 3D genome organization across species from Hi-C data |
| 识别相互作用神经退行性蛋白质之间的铜配位环境：使用14N/15N同位素标记的脉冲EPR新方法 |
Smart, A. |
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N/A |
Identifying the Copper Coordination Environment Between Interacting Neurodegenerative Proteins: A New Approach Using Pulsed EPR with 14N/15N Isotopic Labelling |
| 上皮细胞中HKDC1的缺失减缓了细胞增殖，并损害了肿瘤性上皮细胞的线粒体功能，从而保护小鼠免受肠道癌变的影响。 |
Jaerke, L. |
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N/A |
Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis in mice |
| 过敏性肺炎中的T细胞受体共享 |
Sendama, W. |
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N/A |
T cell receptor sharing in hypersensitivity pneumonitis |
| 替代性cGAS信号传导促进单纯疱疹性脑炎 |
Shmuel-Galia, L. |
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N/A |
Alternative cGAS signaling promotes Herpes simplex encephalitis |
| 转录组学预测夜间人工光照（ALAN）对适应性的影响：夜间光照改变了摇蚊（Chironomus riparius，双翅目：摇蚊科）的基因表达模式，并对适应性成分产生负面影响 |
Eberhardt, L. |
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N/A |
Transcriptomics predicts Artificial Light at Night's (ALAN) impact on fitness: nightly illumination alters gene expression pattern and negatively affects fitness components in the midge Chironomus riparius (Diptera:Chironomidae) |
| 多聚核糖体和mRNA调控真核细胞胞质的生物物理特性 |
Gade, V. R. |
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N/A |
Polysomes and mRNA control the biophysical properties of the eukaryotic cytoplasm |
| 无序玻璃纳米线基底通过光学衍射断层成像揭示了类似体内星形胶质细胞的形态 |
Anantha, P. |
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N/A |
Disordered glass nanowire substrates produce in vivo-like astrocyte morphology revealed by optical diffraction tomography |
| TSSK同源物调控按蚊精氨酸和斯氏按蚊睾丸特异性基因的表达 |
Meghwanshi, K. K. |
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N/A |
TSSK homologue regulates the expression of protamine and mosquito testes specific genes in Anopheles stephensi |
| 泛基因组参考序列改善了从肿瘤测序数据中生物标志物的估计 |
Arslan, E. |
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N/A |
Pangenome References Improve Biomarker Estimation from Tumor Sequencing Data |
| 使用深度学习从基因表达预测泛癌药物敏感性 |
Ocasio, B. A. |
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N/A |
Pan-Cancer Drug Sensitivity Prediction from Gene Expression using Deep Learning |
| 预测的细胞粘附分子MPZL3的丢失促进了卵巢癌中的上皮-间质转化和化学抗性 |
Cheng, Y.-Y. |
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N/A |
Loss of the predicted cell adhesion molecule MPZL3 promotes EMT and chemoresistance in ovarian cancer |