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BioRxiv 2024-11-19 Papers

标题 作者 PDF链接 代码仓库 Title
将昆虫社会的基本概念适应于生物本体论的需求。 Silva, T. S. R. PDF N/A Adapting fundamental concepts from insect societies to the demands of bio-ontologies.
通过咽部神经元对黑腹果蝇的盐味行为进行活动和状态依赖性调节 Kaushik, S. PDF N/A Activity and state-dependent modulation of salt taste behavior via pharyngeal neurons in Drosophila melanogaster
语义控制的晚熟促进了概念的发展 Jackson, R. L. PDF N/A Late maturation of semantic control promotes conceptual development
气味表征表明,在整个嗅觉系统中存在非线性处理过程。 Olivares, J. PDF N/A Odorant representations indicate nonlinear processing across the olfactory system
有效的保护决策需要针对特定目的设计的模型:安大略省“火环”地区北美驯鹿的案例研究 Dyson, M. E. PDF N/A Effective conservation decisions require models designed for purpose: a case study for boreal caribou in Ontario's Ring of Fire
BATCH-SCAMPP:批量缩放的系统发育放置大型树 Wedell, E. PDF N/A BATCH-SCAMPP: Batch Scaled Phylogenetic Placement Large Trees
剖析咖啡因在裂殖酵母中的细胞周期调控、DNA损伤敏感性和寿命效应 Alao, J.-P. PDF N/A Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast
阿尔茨海默病和重度抑郁症中的比较基因调控网络分析揭示了共享的核心调控回路 Puype, H. PDF N/A Comparative gene regulatory network analysis in Alzheimer's disease and major depressive disorder identifies shared core regulatory circuits
帕金森病的分类及从皮脂挥发物组中描绘进展标志物 Walton-Doyle, C. PDF N/A Classification of Parkinson's Disease and Delineating Progression Markers from the Sebum Volatilome
经验生态网络推断的不一致性受统计方法和输入数据维度的考虑所支配。 Kusch, E. PDF N/A Inconsistencies of empirical ecological network inference are governed by considerations of statistical approaches and dimensions of input data
一种适用于慢性神经像素探针的可适应、可重复使用且轻便的植入物 Bimbard, C. PDF N/A An adaptable, reusable, and light implant for chronic Neuropixels probes
解码视觉空间注意力控制 Meyyappan, S. PDF N/A Decoding Visual Spatial Attention Control
评估不同突变发现方法之间的不一致体细胞变异,以最小化药物耐药性发现的假阴性结果 Lin, H.-F. PDF N/A Evaluating discordant somatic calls across mutation discovery approaches to minimize false negative drug-resistant findings
小鼠听觉皮层中的多模态失配反应 Solyga, M. PDF N/A Multimodal mismatch responses in mouse auditory cortex
使用扰动-观察对进行自动模型优化 Park, K. H. PDF N/A Automated Model Refinement Using Perturbation-Observation Pairs
一个热力学框架,用于分析非平衡自组装和分支肌动蛋白网络中的力形态权衡 Rennert, E. PDF N/A A thermodynamic framework for nonequilibrium self-assembly and force morphology tradeoffs in branched actin networks
活体成像揭示了哺乳动物原肠胚形成过程中协调的细胞迁移和心脏命运决定。 Abukar, S. PDF N/A Live-imaging reveals Coordinated Cell Migration and Cardiac Fate Determination during Mammalian Gastrulation.
单细胞多组学揭示了细胞周期中mRNA代谢和染色质可及性的振荡动力学 Nariya, M. K. PDF N/A Single-cell multiomics reveals the oscillatory dynamics of mRNA metabolism and chromatin accessibility during the cell cycle
重复的行为进化与洞巢鸣禽基因表达的定向趋同有关 Lipshutz, S. E. PDF N/A Repeated behavioral evolution is associated with targeted convergence of gene expression in cavity-nesting songbirds
双分病毒内体膜靶向中VP3-PI3P相互作用的作用 Zanetti, F. A. PDF N/A On the Role of VP3-PI3P Interaction in Birnavirus Endosomal Membrane Targeting
抗-B7H3 CAR-T结构的功能亲和力预测了触发效应功能的抗原密度阈值 Barisa, M. PDF N/A Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function
NAD+激活肾脏代谢,并在Alport综合征模型中保护免受慢性肾脏疾病的侵害。 Jones, B. A. PDF N/A NAD+ activates renal metabolism and protects from chronic kidney disease in a model of Alport syndrome
使用QCM-D解码新兴肌动肌球蛋白交叉对话的机械化学影响 Kerivan, E. M. PDF N/A Deciphering Mechanochemical Influences of Emergent Actomyosin Crosstalk using QCM-D
通过综合分析基因表达数据识别胶质母细胞瘤的潜在治疗靶点和生物标志物 Bautista, A. PDF N/A Identification of Potential Therapeutic Targets and Biomarkers for Glioblastomas Through Integrative Analysis of Gene Expression Data
通过函数分配的掩码超串实现高效的k-Mer集合操作 Sladky, O. PDF N/A Towards Efficient k-Mer Set Operations via Function-Assigned Masked Superstrings
嗜水气单胞菌CobQ是一种新型的不依赖NAD+和Zn2+的蛋白质赖氨酸去乙酰化酶。 Wang, Y. PDF N/A Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase
一段基因组复制跨越多个P450基因,有助于登革热蚊子埃及伊蚊的杀虫剂抗性 Bacot, T. PDF N/A A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti
体感诱发电位在啮齿动物中引起广泛的弥散度和峰度变化,这些变化与神经活动相关。 Hertanu, A. PDF N/A Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents
围产期结构丘脑皮质连接的发展 Oldham, S. PDF N/A Perinatal development of structural thalamocortical connectivity
持续的疫苗暴露能更快、更一致且更广泛地激发对多价流感疫苗的体液免疫反应。 Saouaf, O. M. PDF N/A Sustained vaccine exposure elicits more rapid, consistent, and broad humoral immune responses to multivalent influenza vaccines
大脑中双向网络核心与感知觉意识和认知的关联 Taguchi, T. PDF N/A Association of bidirectional network cores in the brain with perceptual awareness and cognition
96孔聚丙烯酰胺凝胶用于电泳和Western印迹 Birtwistle, M. R. PDF N/A A 96-Well Polyacrylamide Gel for Electrophoresis and Western Blotting
多结构域信号蛋白的深度突变扫描揭示了调控机制和致病性 Jiang, Z. PDF N/A Deep mutational scanning of a multi-domain signaling protein reveals mechanisms of regulation and pathogenicity
海马体在类别抽象过程中支持向新状态的插值 Schaefer, T. A. PDF N/A The hippocampus supports interpolation into new states during category abstraction
一种用于在低功耗神经形态硬件上监测癫痫发作的事件驱动神经网络 Bartels, J. PDF N/A An event-driven neural network for monitoring of epileptic seizures on low-power neuromorphic hardware
环二腺苷酸驱动沙眼衣原体发育周期的进展 Lee, J. PDF N/A Cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis
组成性激活的受体ADGRA3信号传导诱导脂肪组织产热 Zhao, Z. PDF N/A Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis
评估漂变和选择在沿海拔梯度特征丧失中的作用 Buysse, S. F. PDF N/A Evaluating the Roles of Drift and Selection in Trait Loss along an Elevational Gradient
特定的突触前功能需要不同的果蝇Cav2剪接异构体 Bell, C. PDF N/A Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms
通过抑制NLRP3炎症小体,被caspase-11/4切割的VgrG2b片段促进了铜绿假单胞菌的感染。 Qian, Y. PDF N/A A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome
基于模型的祖先比例更快速估算 Santander, C. PDF N/A Faster model-based estimation of ancestry proportions
一种全面的蛋白质组结构系统方法揭示了所有人疱疹病毒蛋白质家族的见解 Soh, T. K. PDF N/A A proteome-wide structural systems approach reveals insights into protein families of all human herpesviruses
桡足类化学信号对两种拟菱形藻属物种胞内和胞外毒素的影响 Pourdanandeh, M. PDF N/A Effects of copepod chemical cues on intra- and extracellular toxins in two species of Dinophysis
FuncFetch:一种由大型语言模型辅助的工作流程,能够从已发表的手稿中挖掘出数千种酶-底物相互作用 Smith, N. PDF N/A FuncFetch: An LLM-assisted workflow enables mining thousands of enzyme-substrate interactions from published manuscripts
多物种全基因组CRISPR筛选鉴定出冷诱导细胞死亡的保守抑制因子 Lam, B. PDF N/A Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
年龄相关的听觉脑干髓鞘缺陷会导致鸡尾酒会效应的缺陷。 Poleg, S. PDF N/A Age-related myelin deficits in the auditory brain stem contribute to cocktail party-deficits
高度可扩展的物理交联水凝胶用于高速3D生物打印 Song, Y. E. PDF N/A Highly extensible physically crosslinked hydrogels for high-speed 3D bioprinting
使用机器学习预测单克隆抗体的纯化工艺适用性 Maier, A. J. PDF N/A Predicting purification process fit of monoclonal antibodies using machine learning
可移动元件通过细胞类型特异性的表观基因组关联影响人类调控景观 Hyacinthe, J. PDF N/A Transposable elements impact the human regulatory landscape through cell type specific epigenomic associations
通过整合进化尺度和基于物理的建模来预测金属结合蛋白及其结构 Dai, X. PDF N/A Predicting metal-binding proteins and structures through integration of evolutionary-scale and physics-based modeling
蛋白质工程竞赛结果:蛋白质建模与设计的开放科学基准 Armer, C. PDF N/A Results of the Protein Engineering Tournament: An Open Science Benchmark for Protein Modeling and Design
内侧隔核和Broca斜带中的神经元异质性:类别与连续体 Kuhn, F. PDF N/A Neuronal heterogeneity in the medial septum and diagonal band of Broca: classes and continua
细胞-细胞外基质(ECM)粘附的局部减弱通过改变细胞形状、肌动蛋白-肌球蛋白组织和E-钙粘蛋白水平,触发了基底组织的折叠。 Valencia-Exposito, A. PDF N/A Local weakening of cell-ECM adhesion triggers basal tissue folding via changes in cell shape, actomyosin organization and E-cad levels
阿尔茨海默病突变型γ-分泌酶复合物阻碍了β-淀粉样肽的生成。 Arafi, P. PDF N/A Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production
根据实验室观察,成熟的大黄蜂蛹在夜间仍会继续鸣叫。 FUJIOKA, H. PDF N/A Mature larvae continue calling at night in Vespa mandarinia from laboratory observations
关于前向采样方案密度的近似严格下界 Kille, B. PDF N/A A near-tight lower bound on the density of forward sampling schemes
遗传性铜缺乏和儿童神经退行性变模型中的适应性蛋白质合成 Lane, A. R. PDF N/A Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
利用公开的数据非依赖采集数据集对人类组织中基线蛋白质表达的整合视图 Prakash, A. PDF N/A Integrated View of Baseline Protein Expression in Human Tissues using public Data Independent Acquisition datasets
不同的持续时间和饮食依赖性脂质谱及GCK-MODY中的肾并发症 Huang, Y. PDF N/A Distinct duration and diet dependent lipid profiles and renal complicationsin GCK-MODY
DiffPaSS - 使用软分数进行高性能可微蛋白质序列配对 Lupo, U. PDF N/A DiffPaSS - High-performance differentiable pairing of protein sequences using soft scores
多尺度光场显微镜平台,用于多功能动态体积生物成像 Bai, Y. PDF N/A Multiscale Light Field Microscopy Platform for Multi-purpose Dynamic Volumetric Bioimaging
CalTrig:一种基于图形用户界面的机器学习方法,用于解码自由活动啮齿动物中的神经元钙瞬变 Lange, M. A. PDF N/A CalTrig: A GUI-based Machine Learning Approach for Decoding Neuronal Calcium Transients in Freely Moving Rodents
基于系统发育的模拟表明,在真核生物起源时期,未采样的谱系对基因流推断的影响较小。 Bernabeu, M. PDF N/A Phylogeny-aware simulations suggest a low impact of unsampled lineages in the inference of gene flow during eukaryogenesis
用于高效遗传种群鉴定的特诺河大西洋鲑(Salmo salar)种群复合体的单核苷酸多态性基因分型面板 Johansson, H. PDF N/A A single nucleotide polymorphism genotyping panel for efficient genetic stock identification of the Teno river Atlantic salmon (Salmo salar) population complex
解读未开发古菌域中RiPPs的化学语言 Song, Z.-m. PDF N/A Decoding the chemical language of RiPPs from the untapped Archaea domain
Vispro 提升了 Visium 空间转录组学的成像分析 Ma, H. PDF N/A Vispro improves imaging analysis for Visium spatial transcriptomics
深度学习助力Pharos平台发现激酶药物靶点 Halasz, A. M. PDF N/A Deep Learning enabled discovery of kinase drug targets in Pharos
利用-配对目标的RF扩散改进蛋白质结合剂设计 Sappington, I. PDF N/A Improved protein binder design using -pairing targeted RFdiffusion
多站点研究中基于扩散MRI的结构连接组的协调 Shen, R. S. PDF N/A Harmonization of Diffusion MRI-based Structural Connectomes for Multi-site Studies
赋予抗真菌药物抗性的RNAi表观突变是可遗传的。 Perez-Arques, C. PDF N/A RNAi epimutations conferring antifungal drug resistance are inheritable
光照在弱电鱼的活动感知和控制中起着中介作用,能够调节其行为模式。 Yeh, H. PDF N/A Illumination mediates a switch in both active sensing and control in weakly electric fish
全球范围内对预测模型进行基准测试,揭示长期中风结果的机制多样性 Matsulevits, A. PDF N/A A global effort to benchmark predictive models and reveal mechanistic diversity in long-term stroke outcomes
SpotMAX:一种用于多维自动斑点检测和定量的通用框架 Padovani, F. PDF N/A SpotMAX: a generalist framework for multi-dimensional automatic spot detection and quantification
II型-B CRISPR-Cas9增强特异性的机制 Hibshman, G. N. PDF N/A Mechanism of type II-B CRISPR-Cas9 enhanced specificity
在人细胞培养中5-氟尿嘧啶处理下RNA修饰的时间定位 Berg, M. PDF N/A Temporal placement of RNA modifications under 5-fluorouracil treatment in human cell culture
一种跨越动物和环境的普遍海马体记忆编码 Wirtshafter, H. S. PDF N/A A universal hippocampal memory code across animals and environments
跨动物和环境的海马体通用记忆编码 Wirtshafter, H. S. PDF N/A A universal hippocampal memory code across animals and environments
使用多重竞争性等位基因特异性PCR(mxKASP)基因分型确定合子性 de Visser, M. C. PDF N/A Determining zygosity with multiplex Kompetitive Allele-Specific PCR (mxKASP) genotyping
保守的基因内容和独特的系统发育历史特征了Triturus平衡致死系统背后的“bloopergene” de Visser, M. C. PDF N/A Conserved gene content and unique phylogenetic history characterize the 'bloopergene' underlying Triturus' balanced lethal system
NewtCap:一种高效的目标捕获方法,用于提升蝾螈科(真蝾螈和新蝾螈)的基因组研究 de Visser, M. C. PDF N/A NewtCap: an efficient target capture approach to boost genomic studies in Salamandridae (True Salamanders and Newts)
普通狨猴的拉绳行为 Bertrand, M. PDF N/A String-pulling by the common marmoset
PAV-spotter:利用信号互相关识别目标捕获数据中的存在/缺失变异 de Visser, M. C. PDF N/A PAV-spotter: using signal cross-correlations to identify Presence/Absence Variation in target capture data
保守的转录因子通过抑制作用协调突触基因的表达 Kentro, J. A. PDF N/A Conserved transcription factors coordinate synaptic gene expression through repression
微生物转录对宿主饮食的反应维持了美洲大蠊肠道微生物群的稳态 DePoy, A. N. PDF N/A Microbial transcriptional responses to host diet maintain gut microbiome homeostasis in the American cockroach
mcRigor:一种用于增强单细胞数据分析中metacell划分严谨性的统计方法 Liu, P. PDF N/A mcRigor: a statistical method to enhance the rigor of metacell partitioning in single-cell data analysis
稀有物种并未过度贡献于亚高山植物群落的系统发育多样性 Veldhuisen, L. N. PDF N/A Rare species do not disproportionately contribute to phylogenetic diversity in a subalpine plant community
秋水仙碱抑制小鼠平滑肌细胞表型转换及主动脉夹层 Jiang, H. PDF N/A Colchicine Inhibits Smooth Muscle Cell Phenotypic Switch and Aortic Dissection in Mice
一种关于单细胞习惯化的受体失活模型,适用于蓝钟虫(Stentor coeruleus) Rajan, D. H. PDF N/A A receptor-inactivation model for single-celled habituation in Stentor coeruleus
全息层析显微镜揭示了在血管内皮化过程中,无需标记的血管内皮细胞定量动态变化。 Leineweber, W. D. PDF N/A Holotomographic microscopy reveals label-free quantitative dynamics of endothelial cells during endothelialization
调节注意力网络中与学习相关的可塑性 Conto, F. PDF N/A Modulation of learning-dependent plasticity in the attention network
基因重复后表达变异性的增加有助于基因的保留 Cai, H. PDF N/A Expression variability following gene duplication facilitates gene retention
ROSIE:从组织病理学图像中生成多重免疫荧光染色的人工智能技术 Wu, E. PDF N/A ROSIE: AI generation of multiplex immunofluorescence staining from histopathology images
有丝分裂CIP2A-TOPBP1轴促进有丝分裂途径在MiDAS和MMEJ之间的选择。 Martin, P. R. PDF N/A The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ
小窝蛋白-1和AQP4作为遗传性脑淀粉样血管病中纤维蛋白原驱动脑血管病理的介质 Singh, V. PDF N/A Caveolin-1 and Aquaporin-4 as Mediators of Fibrinogen-Driven Cerebrovascular Pathology in Hereditary Cerebral Amyloid Angiopathy
表观遗传调节NLRP6炎症小体传感器作为一种治疗手段,以减少HIV/SIV感染中由坏死性凋亡驱动的胃肠黏膜功能障碍 Premadasa, L. S. PDF N/A Epigenetic modulation of NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection
区分果蝇中轻度、重度及非典型过氧化物酶体生成障碍的PEX基因变异严重程度 Gomez, V. A. PDF N/A Distinguishing PEX gene variant severity for mild, severe, and atypical peroxisome biogenesis disorders in Drosophila
无序玻璃纳米线基底通过光学衍射断层成像揭示了类似体内的星形胶质细胞形态 Anantha, P. PDF N/A Disordered glass nanowire substrates produce in vivo-like astrocyte morphology revealed by optical diffraction tomography
一种伴有婴儿肠结肠炎的自发性炎症的动物模型 Wang, Y. PDF N/A An animal model for autoinflammation with infantile enterocolitis
一种伴有婴儿肠结肠炎的自发性炎症动物模型 Wang, Y. PDF N/A An animal model for autoinflammation with infantile enterocolitis
通过微活检皮肤样本在不同温度下的mRNA管家基因稳定性分析,推进远程和低资源医疗服务的提供 Nataren, N. PDF N/A Advancing Remote and Low-Resource Healthcare Delivery with Microbiopsy Skin Sample mRNA Housekeeping Gene Stability Analysis Across Various Temperatures
酶约束的梅毒螺旋体代谢模型鉴定出甘油-3-磷酸脱氢酶作为替代电子受体 Shahreen, N. PDF N/A Enzyme-constrained Metabolic Model of Treponema pallidum Identified Glycerol-3-phosphate Dehydrogenase as an Alternate Electron Sink
基质硬度决定人肺成纤维细胞中独特的阿霉素诱导的衰老相关分泌表型和转录组特征 Du, H. PDF N/A Substrate Stiffness Dictates Unique Doxorubicin-induced Senescence-associated Secretory Phenotypes and Transcriptomic Signatures in Human Pulmonary Fibroblasts
磷脂酰乙醇胺是一种吞噬性配体,参与微生物胞外囊泡的结合和清除。 Kavianpour, A. PDF N/A Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of microbial extracellular vesicles
补偿传感器运动延迟需要一个记忆缓冲区、一个状态观测器和一个预测器。 Maris, E. PDF N/A Compensating for a sensorimotor delay requires a memory buffer, a state observer, and a predictor
氯离子稳态的动态变化在奖励学习过程中协调中脑抑制性网络活动 Woo, J. PDF N/A Dynamic Changes in Chloride Homeostasis Coordinate Midbrain Inhibitory Network Activity during Reward Learning
使用多电极阵列对人类诱导多能干细胞衍生的感觉神经元进行分析,以用于镇痛药物筛选 Kuete, C. F. PDF N/A Profiling Human iPSC-Derived Sensory Neurons for Analgesic Drug Screening Using a Multi-Electrode Array
近红外光疗法治疗神经退行性疾病的效果评估:穿透深度有限,可能影响疗效 Tittelmeier, J. PDF N/A Evaluation of near-infrared light therapy for the treatment of neurodegenerative diseases: Limited penetration depth into the brain likely hinders efficacy
在刺激暴露期间,婴儿的大脑会迅速适应视觉统计规律。 Capparini, C. PDF N/A The infant brain rapidly entrains to visual statistical regularities during stimulus exposure
前庭信号到初级视觉皮层(V1)的半球间和半球内来源 Bouvier, G. PDF N/A Inter- and Intrahemispheric Sources of Vestibular Signals to V1
关于吸引力序列依赖背后的决策过程的神经证据 Shan, J. PDF N/A Neural evidence for decision-making underlying attractive serial dependence
在呼气末二氧化碳质量较低时,使用屏气BOLD fMRI进行脑血管反应性振幅和延迟的定量映射 Clements, R. G. PDF N/A Quantitative mapping of cerebrovascular reactivity amplitude and delay with breath-hold BOLD fMRI when end-tidal CO2 quality is low
优化肌萎缩侧索硬化症(ALS)患者脑室内人神经干细胞移植的非临床方案中的挑战与前景 Lombardi, I. PDF N/A Challenges and promises in optimising a non-clinical protocol of intracerebroventricular human neural stem cell transplantation in ALS
通过药理学和遗传学方法揭示阿尔茨海默病中依赖与不依赖小胶质细胞的脑脂质代谢调控 Xu, Z. PDF N/A Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion
行为风险模型解释了在虚拟高度行走时的运动和平衡变化 Seddighi, N. PDF N/A Behavioral risk models explain locomotor and balance changes when walking at virtual heights
绘制DUSP6在ADHD iPSC衍生的多巴胺能神经元模型中的影响 Namipashaki, A. PDF N/A Mapping the impact of DUSP6 in an ADHD iPSC derived-dopaminergic neuronal model
治疗朊病毒病的治疗窗口由朊蛋白的定时消耗定义 Bradford, B. M. PDF N/A Therapeutic window for treatment of prion disease defined by timed depletion of Prion protein
靶向激活小胶质细胞PPARδ可重编程免疫代谢并增强饮食诱导肥胖中的胰岛素敏感性。 Jiao, H. PDF N/A Targeted activation of microglial PPARdelta reprograms immunometabolism and enhances insulin sensitivity in diet-induced obesity.
顶叶经颅交流电刺激对时间预测的三角相位依赖性调制 Burke, R. PDF N/A Delta phase-dependent modulation of temporal predictions by parietal transcranial alternating current stimulation
基于连接组学的特征选择性皮质回路模型 Buendia, V. PDF N/A Connectome-based models of feature selectivity in a cortical circuit
沿着皮层层次对视觉区域进行多模态分层表征 Pizzuti, A. PDF N/A Multimodal laminar characterization of visual areas along the cortical hierarchy
在发作性偏头痛患者中,攻击想象期间疼痛网络的激活受到干扰 Perdigao, A. PDF N/A Disrupted activation of pain networks during attack imagery in patients with episodic migraine
GABA和甘氨酸在轴突切断的运动神经元细胞体上的突触释放,促进了运动轴突的再生。 Wood, R. L. PDF N/A GABA and glycine synaptic release on axotomized motoneuron cell bodies promotes motor axon regeneration
在类似体内状态下树突突触整合模式 Ceballos, C. C. PDF N/A Dendritic synaptic integration modes under in vivo-like states
生成网络模型未能准确捕捉到长程连接性。 Oldham, S. PDF N/A Coming up short: generative network models fail to accurately capture long-range connectivity
拓扑异构酶3A(TOP3A)依赖的端粒延长替代机制(ALT) KHANDAGALE, P. R. PDF N/A Topoisomerase 3A (TOP3A) Dependent Alternative Lengthening of Telomeres (ALT)
CD40交联诱导的ERK激活促进了自噬,从而增强了宫颈癌细胞的放射敏感性。 Liu, B. PDF N/A CD40 ligation-induced ERK activation promotes autophagy which leads to enhanced radiosensitivity in cervical carcinoma cells
抑制GEF-H1-RhoA信号通路在炎症中的作用:通过模拟RhoA67-78螺旋的钉合肽 Gathmann, C. PDF N/A Inhibition of GEF-H1-RhoA signaling in inflammation with a stapled peptide mimicry of the RhoA67-78 helix
血管壁细胞保护成年大脑免受出血,但在发育中的斑马鱼中并不控制血脑屏障。 Baltaci, O. F. PDF N/A Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish
动物社会网络分析中未测量变量的问题:基于边的多层次模型能否提供可靠的解决方案? Bonnell, T. PDF N/A The problem of unmeasured variables in animal social network analysis: can edge-based multilevel models provide a reliable solution?
阿尔茨海默病中的小胶质细胞状态易受衰老和胆固醇失调的影响 Li, B. PDF N/A Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease
优化的人类诱导多能干细胞衍生的肝细胞的开发,以改善体外代谢疾病建模和毒性研究中的肝脏功能 Lukasiak, M. PDF N/A Development of optimised human iPSC-derived hepatocytes with improved liver function for in vitro metabolic disease modelling and toxicity studies
体内人体子宫温度、pH值及子宫液成分分析 Tarahomi, M. PDF N/A In vivo human uterine temperature, pH, and uterine fluid composition analysis
在调整淋巴细胞后,帕金森病全血RNA分析中SNCA表达的降低 Xu, K. PDF N/A Decreased SNCA Expression in Whole-Blood RNA Analysis of Parkinson's Disease Adjusting for Lymphocytes
自闭症谱系障碍中的低代谢:来自脑部和血液转录组学的见解 Balasubramanian, R. PDF N/A Hypometabolism in Autism Spectrum Disorder: Insights from Brain and Blood Transcriptomics
对加纳北部黄热病暴发的昆虫学调查 Osei, J. H. N. PDF N/A Entomological investigations into yellow fever outbreak in northern Ghana
评估脑龄作为脑健康的特定标志 Tan, T. W. K. PDF N/A Evaluation of Brain Age as a Specific Marker of Brain Health
从生物技术角度对源于真菌的抗菌药物进行综合文献计量研究 Da Silva, L. L. PDF N/A A Comprehensive Bibliometric Investigation on Antimicrobials from Fungal Origins with a Biotechnological Perspective
埃塞俄比亚塔纳湖湖滨湿地综合湿地状况指数的开发与应用 Wondim, Y. K. PDF N/A Development and use of integrated wetland condition index for lacustrine fringe wetlands of Lake Tana, Ethiopia
在问题解决过程中,眼睛和手的协同发音揭示了层级组织的规划。 Eluchans, M. PDF N/A Eye and hand coarticulation during problem solving reveals hierarchically organized planning
在蛋白质组尺度上分析氨基酸替代揭示了癌症疾病中的新型蛋白质调控 Zhao, P. PDF N/A Profiling amino acid substitution on proteomic scale unveils novel protein regulation in cancer diseases
双时间尺度电机电路动力学是快速头部探索行为和高效运动的基础 Li, P. PDF N/A Dual-timescale motor circuit dynamics underlies fast head exploratory behavior and efficient locomotion
ELAVL3调控D1和D2纹状体中型多棘神经元中编码突触信号蛋白的RNA剪接。 Irmady, K. PDF N/A ELAVL3 regulates splicing of RNAs encoding synaptic signaling proteins in D1 and D2 striatal medium spiny neurons.
Pick病中tau聚集体的分子多态性 Liu, J. PDF N/A Molecular Polymorphism of tau aggregates in Pick's disease
CATSPERε的胞外域在发育过程中对CatSper的组装以及精子获能过程中的活性调节至关重要。 Hwang, J. Y. PDF N/A Extracellular domains of CATSPERε are essential for CatSper assembly during development and activity modulation in sperm capacitation
学术交流中的骗局趋势 Faulkes, Z. PDF N/A Trends in hoaxes of academic communication
病原体威胁的接近程度塑造了宿主在感染前反应中的胞外囊泡产生 Kolodziejska, K. PDF N/A Pathogen threat proximity shapes host extracellular vesicle production in pre-infection response
静纤毛高度的变化可以解释外毛细胞束静息状态对钙的依赖性。 Chatterjee, R. PDF N/A Stereocilium height changes can account for the calcium dependence of the outer-hair-cell bundle's resting state
利用临床试验数据和深度辅助学习优化三阴性乳腺癌新辅助治疗反应预测 Moon, C. I. PDF N/A Optimizing Neoadjuvant Treatment Response Prediction for Triple-Negative Breast Cancer Using Clinical Trial Data and Deep Auxiliary Learning
姜黄素和胡椒碱通过模拟和人工智能方法预防和治疗乳腺癌的分析 Sivakumar, A. PDF N/A Analysis of Curcumin and Piperine for Breast Cancer Prevention and Treatment via Simulation and Artificial Intelligence Methods
一种合成钾通道通过细胞自适应技术减轻氧化应激 Russo, A. PDF N/A A synthetic potassium channel reduces oxidative stress 1 via cellular adaptronics
病理性α-突触核蛋白截断和突变对相分离的不同影响 Ray, S. PDF N/A Divergent effects of pathological α-synuclein truncations and mutations on phase separation
通过体外重建揭示的染色质复制偶联对称组蛋白再循环的最小蛋白质列表 Nagae, F. PDF N/A Minimal protein list for chromatin replication-coupled symmetric histone recycling revealed through in vitro reconstitution
具有全局抑制的决策集成伊辛模型 Tapinova, O. PDF N/A Integrated Ising Model with global inhibition for decision making
PTK7靶向放射性核素治疗的临床前评估 Lindland, K. PDF N/A Preclinical Evaluation of PTK7-Targeted Radionuclide Therapy
线性-二次模型(以及LQ模型的来源)的一个简单新替代方案 Bilinsky, L. PDF N/A A simple new alternative to the linear-quadratic model (and where the LQ model comes from)
巴雷特食管和癌症的单细胞分析揭示了通过遗传易感性赋予风险的细胞类型 Wenzel, M. C. PDF N/A Single cell analysis of Barrett's esophagus and carcinoma reveals cell types conferring risk via genetic predisposition
自监督学习发现的3446张全切片图像中切除的间皮瘤组织形态学图谱 Seyedshahi, F. PDF N/A A histomorphological atlas of resected mesothelioma from 3446 whole-slide images discovered by self-supervised learning
mGluR同源和异源二聚体的独特药理学特性 McCullock, T. W. PDF N/A Unique Pharmacology of mGluR homo- and heterodimers
对玉米驯化过程中根系表型演变的硅基分析——以特瓦坎新石器时代土壤为例 Lopez-Valdivia, I. PDF N/A In silico analysis of the evolution of root phenotypes during maize domestication in Neolithic soils of Tehuacan
创新性突变筛选鉴定出TRANSPARENT TESTA7在种子油/蛋白质分配中的作用 Lecureuil, A. PDF N/A Innovative mutant screening identifies TRANSPARENT TESTA7 as a player in seed oil/protein partitioning
X射线计算机断层扫描技术的应用彻底改变了土壤病原体的检测方式。 Pereira, E. C. PDF N/A The use of X-ray Computed Tomography revolutionises soil pathogen detection
关于Farlowella colombiensis Retzer & Page 1997的分类地位及F. acus物种组(Loricariidae科:Loricariinae亚科)物种的评注。 Melo-Ortiz, O. E. PDF N/A The taxonomic status of Farlowella colombiensis Retzer & Page 1997 with comments on species of the F. acus species group (Loricariidae: Loricariinae).
情绪通过偏差学习奖励可能性来影响信心 Mason, L. PDF N/A Mood impacts confidence through biased learning of reward likelihood
健康成年和新生儿非裔美国人皮肤中IL1A/IRAK1轴及其下游促炎信号的激活 Trubetskoy, D. PDF N/A Activation of IL1A/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin
与干扰素相关的B细胞过度活跃在携带Sm/RNP抗体的系统性红斑狼疮患者中高度富集。 Van Dooren, H. J. PDF N/A IFN-associated B cell hyperactivity is highly enriched in SLE patients harboring Sm/RNP antibodies
囊性纤维化患者来源的铜绿假单胞菌菌株中噬菌体防御系统减少 van den Berg, D. F. PDF N/A Reduced prevalence of phage defense systems in Pseudomonas aeruginosa strains from Cystic Fibrosis Patients
模拟人类子宫pH值和液体成分的胚胎培养基中的人类囊胚形成 Zagers, M. S. PDF N/A Human blastocyst formation in an embryo culture medium mimicking human uterine pH and fluid composition
全球生物地理学与具叶绿体孢子蕨类的进化驱动力 Mellado-Mansilla, D. PDF N/A GLOBAL BIOGEOGRAPHY AND EVOLUTIONARY DRIVERS OF FERNS WITH CHLOROPHYLLOUS SPORES
使用简单二分类器在FlowCAM中进行碎屑识别 Garcia-Oliva, O. PDF N/A Detritus identification in FlowCAM using a simple binary classifier
互惠的主-沃尔巴克氏体相互作用塑造了单倍二倍体中细胞质不兼容性丧失后的感染持久性 KAUAI, F. PDF N/A Reciprocal host-Wolbachia interactions shape infection persistence upon loss of cytoplasmic incompatibility in haplodiploids
使用卷积神经网络检测种间正选择 West, C. PDF N/A Detecting interspecific positive selection using convolutional neural networks
鲸偶蹄目中上皮钠通道delta亚单位的进化路径表明其在钠感应中的作用 Zahnow, F. PDF N/A The evolutionary path of the epithelial sodium channel delta-subunit in Cetartiodactyla points to a role in sodium sensing
有害突变可以促进性染色体间重组抑制的进化。 Jay, P. PDF N/A Deleterious mutations can contribute to the evolution of recombination suppression between sex chromosomes
着丝粒附近的交叉会破坏减数分裂过程中同源染色体的正常分离。 Sen, S. PDF N/A Centromere-proximal crossovers disrupt proper homologous chromosome disjunction during meiosis
优化多样化碱基编辑器以进行单核苷酸变异的高通量研究 Schwartz, C. I. PDF N/A Towards optimizing diversifying base editors for high-throughput studies of single-nucleotide variants
时空T细胞追踪用于儿童癌症个性化TCR-T设计 Sentis, I. PDF N/A Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancer
Id1促进功能丧失型Tet2小鼠的克隆性造血 Singh, S. PDF N/A Id1 Promotes Clonal Hematopoiesis in Mice with Tet2 Loss of Function
准备用于核型分析和荧光原位杂交(FISH)的高质量番红花属植物染色体铺片 El-nagish, A. PDF N/A Preparing high-quality chromosome spreads from Crocus species for karyotyping and FISH
可扩展的无细胞生产活性T7 RNA聚合酶 Rezvani, R. N. PDF N/A Scalable cell-free production of active T7 RNA polymerase
哺乳动物大脑发育和进化中的双重计算系统 Imam, N. PDF N/A Dual Computational Systems in the Development and Evolution of Mammalian Brains
人类和狨猴在基于形状的视觉面孔辨别行为中表现出相似的面孔识别特征。 Jeon, Y.-N. PDF N/A Humans and marmosets share similar face recognition signatures in shape-based visual face discrimination behavior
利用扩散MRI中的基于模拟推理进行不确定性映射和概率性纤维束追踪:与经典贝叶斯方法的比较 Manzano-Patron, J. P. PDF N/A Uncertainty mapping and probabilistic tractography using Simulation-Based Inference in diffusion MRI: A comparison with classical Bayes
面向多模态纵向分析:利用神经影像生物标志物、认知评估及人口统计数据预测认知衰退 Ashish, R. M. PDF N/A Towards Multimodal Longitudinal Analysis for Predicting Cognitive Decline Using Neuroimaging Biomarkers, Cognitive Assessments, and Demographic Data
PIEZO2机械敏感性离子通道在脂肪感觉神经支配中起关键作用 Wang, Y. PDF N/A A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation
时间预期调节额叶与感觉脑区之间的耦合 Nagy, P. PDF N/A Temporal expectations modulate coupling between frontal and sensory brain areas
感觉丧失后关键期后的丘脑皮质连接的转录和生理适应 Iyer, L. PDF N/A Post-Critical Period Transcriptional and Physiological Adaptations of Thalamocortical Connections after Sensory Loss
通过浦肯野细胞特异性删除Scn1b建立的发育性和癫痫性脑病小鼠模型 Guillen, F. I. PDF N/A A novel mouse model for developmental and epileptic encephalopathy by Purkinje cell-specific deletion of Scn1b
脊椎动物的视觉起源于竞争的锥体电路。 Fornetto, C. PDF N/A Vertebrate vision is ancestrally based on competing cone circuits
由激励驱动的可卡因觅药习惯与纹状体星形胶质细胞中多巴胺转运体的下调有关。 Fouyssac, M. PDF N/A Compulsion derived from incentive cocaine-seeking habits is associated with a downregulation of the dopamine transporter in striatal astrocytes
敲低TTLL1可减轻Aβ诱导的人诱导多能干细胞衍生的皮层神经元中的TAU病理 Al Kabbani, M. A. PDF N/A Knockdown of TTLL1 reduces Aβ-induced TAU pathology in human iPSC-derived cortical neurons
用于编码和解码与眼球运动相关神经活动的“眼反应函数” Gehmacher, Q. PDF N/A The "Ocular Response Function" for encoding and decoding oculomotor related neural activity
第二/三层连接的同向性偏差:自发、视觉和光遗传驱动的第一视皮层动态的统一机制 Rozsa, T. PDF N/A Iso-orientation bias of layer 2/3 connections: the unifying mechanism of spontaneous, visually and optogenetically driven V1 dynamics
气味调节焦虑水平,但脑电图和心电图评估可能与主观报告存在差异 Morozova, M. PDF N/A Scents Modulate Anxiety Levels, but Electroencephalographic and Electrocardiographic Assessments Could Diverge from Subjective Reports
听觉注意对唤醒的全球性和选择性影响:来自瞳孔扩张的洞察 Grandjean, A. PDF N/A Global and selective effects of auditory attention on arousal: insights from pupil dilation
与骨关节炎相关的鞘脂类神经酰胺34:1在老鼠中引起炎症性疼痛 Rickman, R. H. PDF N/A The osteoarthritis associated sphingolipid sphingomyelin 34:1 causes inflammatory pain in mice
体内CRISPR筛选鉴定出影响多发性骨髓瘤中CAR T细胞功能的关键修饰因子 Korell, F. PDF N/A In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma
综合宏基因组学与血液生物标志物分析揭示了运动员和非运动员在有氧和无氧干预下的不同代谢反应 Zielinska, K. PDF N/A Integrative Metagenomic and Blood Biomarker Analysis Reveals Distinct Metabolic Responses to Aerobic and Anaerobic Interventions in Athletic and Non-Athletic Individuals
肠道微生物及其代谢产物介导阻塞性睡眠呼吸暂停诱发的动脉粥样硬化 Xue, J. PDF N/A Gut Microbiota and Derived Metabolites Mediate Obstructive Sleep Apnea Induced Atherosclerosis
基于结冷胶的营养培养基增加了土壤微生物培养群落的多样性 Kulikova, D. PDF N/A Gellan gum-based nutrient medium increases the diversity of cultivated groups of soil microorganisms
大规模半自动化病毒传播定量分析揭示了斑块形成的多相结构 Howell, L. M. PDF N/A Large scale semi-automated quantification of viral spread reveals multi-phasic structure of plaque formation
YTHDF1和YTHDC1 m6A阅读器蛋白调控HTLV-1 tax和hbz的活性 King, E. M. PDF N/A YTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity
RNA结合蛋白LIN28A在神经元分化过程中介导染色质动态变化 Piscitelli, S. PDF N/A The RNA binding protein LIN28A mediates chromatin dynamics during neuronal differentiation
肥胖相关的MRAP2变异损害了多个MC4R介导的信号通路 Wyatt, R. A. PDF N/A Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways
人类脊髓类器官揭示细胞插入作为次级神经胚形成的一种保守机制 Blanco-Ameijeiras, J. PDF N/A HUMAN SPINAL CORD ORGANOIDS REVEAL CELL INTERCALATION AS A CONSERVED MECHANISM FOR SECONDARY NEURULATION
白海沿岸寡毛纲动物Lumbricillus sp.作为环节动物发育研究的模型 Matveicheva, E. P. PDF N/A The White Sea littoral oligochaete Lumbricillus sp. as a model for annelid development studies
人类和小鼠造血干细胞的单细胞谱系偏向比较 Shamie, I. PDF N/A Comparative single-cell lineage bias in human and murine hematopoietic stem cells
RNA编辑是未修饰人体细胞中的分子钟 Ghareeb, A. E. PDF N/A RNA editing is a molecular clock in unmodified human cells
纳米孔测序技术在检测多种DNA修饰方面的关键评估 Kong, Y. PDF N/A Critical assessment of nanopore sequencing for the detection of multiple forms of DNA modifications
空间解析活体CRISPR筛选测序通过Perturb-DBiT Baysoy, A. PDF N/A Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT
从RNA-蛋白质相互作用预测RNA稳定性的细胞类型特异性 Saran, S. PDF N/A Cell-type specific prediction of RNA stability from RNA-protein interactions
构建一个互惠底物处理木质纤维二糖的共生假单胞菌菌群 Buryskova, B. PDF N/A Building a syntrophic Pseudomonas putida consortium with reciprocal substrate processing of lignocellulosic disaccharides
开发一种针对自噬靶向降解的p62生物降解剂 Thiel, Z. PDF N/A Development of a p62 biodegrader for autophagy targeted degradation
前外侧系统中表达生长抑素神经元的解剖学特征 Ma, W. PDF N/A Anatomical characterisation of somatostatin-expressing neurons belonging to the anterolateral system
早期生命免疫激活塑造小胶质细胞反应并减少5xFAD小鼠的Aβ病理 Yang, Y. PDF N/A Early-Life Immune Activation Shapes Microglial Responses and Reduces Abeta Pathology in 5xFAD mice
2024年5月老年人血清中针对SARS-CoV-2 KP.3.1.1和XEC的中和抗体水平较低 Fossum, E. PDF N/A Low levels of neutralizing antibodies against SARS-CoV-2 KP.3.1.1 and XEC in serum from seniors in May 2024
CRAGE-RB-PI-seq技术能够在植物根系定殖过程中对根际细菌进行转录组分析。 Honda, T. PDF N/A CRAGE-RB-PI-seq enables transcriptional profiling of rhizobacteria during plant-root colonization
微生物群的宿主起源驱动小鼠的功能恢复和艰难梭菌清除 Millard, S. A. PDF N/A Host origin of microbiota drives functional recovery and Clostridioides difficile clearance in mice
与越南H5N1分离株相比,牛源H5N1在小鼠中表现出增强的脑炎趋向性。 Goldin, K. PDF N/A Enhanced encephalitic tropism of bovine H5N1 compared to the Vietnam H5N1 isolate in mice
PTBP1通过HIF-1α信号被寨卡病毒感染上调,并劫持NS1蛋白以诱导NS1降解,从而抑制病毒复制。 Rao, M. PDF N/A PTBP1 is upregulated by Zika virus infection via HIF-1alpha signal and hijacks NS1 protein to induce NS1 degradation to restrain viral replication
一种无抗生素的抗菌组合:细菌素与肽聚糖水解酶的组合:体外和体内评估其功效 Kranjec, C. PDF N/A An antibiotic-free antimicrobial combination of bacteriocins and a peptidoglycan hydrolase: in vitro and in vivo assessment of its efficacy
一种高度保守的小RNA在百日咳博德特菌的毒力模式中下调多个基因,包括一个sigma54转录激活因子。 Sim, M. PDF N/A A highly conserved sRNA downregulates multiple genes, including a sigma54 transcriptional activator, in the virulence mode of Bordetella pertussis
小檗碱:一种兼具抗HIV和抗宫颈癌作用的化合物 Naushad, W. PDF N/A Berberine: A dual anti-HIV and anti- cervical cancer compound
eDNA复制、聚合酶和扩增子大小影响跨栖息地丰富度的推断 Anmarkrud, J. A. PDF N/A eDNA replicates, polymerase and amplicon size impact inference of richness across habitats
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