| 解决方案结构和突触分析揭示了双特异性T细胞衔接子效力的决定因素 |
Leithner, A. |
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N/A |
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency |
| 解构富营养化与自然变异对法国沿海潟湖大型底栖生物群落的影响 |
Jones, A. G. |
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N/A |
Disentangling the effects of eutrophication and natural variability on macrobenthic communities across French coastal lagoons |
| 患者差异对肾素-血管紧张素系统影响的数学建模及其在COVID-19肺纤维化结果中的应用 |
Islam, M. A. |
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Mathematical Modeling of Impacts of Patient Differences on Renin-Angiotensin System and Applications to COVID-19 Lung Fibrosis Outcomes |
| 在转基因烟草植物从烟草蚀纹病毒感染中恢复期间，胼胝质在胞间连丝处的沉积表明其在病毒移动限制中起作用。 |
Vargas-Mejia, P. |
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Callose deposition at plasmodesmata suggests a role in viral movement restriction in transgenic tobacco plants during recovery from Tobacco etch virus infection |
| 轻度多动症有益吗？在整个人口中，大脑的临界性在多动症症状评分处于中间水平时达到峰值。 |
Haque, H. |
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N/A |
Is mild ADHD beneficial? Brain criticality peaks at intermediate ADHD symptom scores across the population |
| 复杂性状遗传学中建模上下文依赖性的权衡 |
Weine, E. |
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N/A |
Tradeoffs in Modeling Context Dependency in Complex Trait Genetics |
| 多巴胺能神经元中食欲素受体1型缺乏增加新奇诱导的 locomotion 和探索 |
Xiao, X. |
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Deficiency of Orexin Receptor Type 1 in Dopaminergic Neurons Increases Novelty-Induced Locomotion and Exploration |
| 肿瘤相关巨噬细胞的抗原呈递促使肿瘤浸润T细胞从原初耗竭状态转变为终末耗竭状态。 |
Waibl Polania, J. |
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Antigen presentation by tumor-associated macrophages drives tumor-infiltrating T cells from a progenitor exhaustion state to terminal exhaustion |
| bamSliceR：一个用于快速跨队列变异分析的Bioconductor包 |
Huang, Y. P. |
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bamSliceR: a Bioconductor package for rapid, cross-cohort variant analysis |
| 贴纸-间隔物能量的分离控制了亚稳态凝聚物的聚结 |
Chattaraj, A. |
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Separation of sticker-spacer energetics governs the coalescence of metastable condensates |
| 肝窦内皮细胞构成了血红蛋白清除的主要途径。 |
Zurawska, G. |
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Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance |
| 解析NAP-CNB机器学习增强型肿瘤新抗原预测的力量 |
Mendez-Perez, A. |
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N/A |
Unraveling the Power of NAP-CNB's Machine Learning-enhanced Tumor Neoantigen Prediction |
| 研究地钱（Marchantia polymorpha）中的顶端切口、顶端优势及分生组织再生的现象。 |
Marron, A. O. |
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Investigating the apical notch, apical dominance and meristem re-emergence in Marchantia polymorpha. |
| ELF3-BBX24/BBX25-PIF4模块控制拟南芥的热感应生长 |
Malakar, B. C. |
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The ELF3-BBX24/BBX25-PIF4 module controls thermosensory growth in Arabidopsis |
| 时间注意在中间处理阶段增强了前扣带回皮层的刺激信息 |
Zhu, J. |
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Temporal attention amplifies stimulus information in fronto-cingulate cortex at an intermediate processing stage |
| 投射至腹侧CA1区的内梨状神经元是识别记忆的关键节点。 |
Yamawaki, N. |
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Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory |
| 自噬蛋白ATG14通过防止非计划性的细胞焦亡激活，从而在早期妊娠期间保障胚胎运输。 |
POPLI, P. |
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The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy |
| 开发无细胞平台以发现、表征和工程化翻译后修饰 |
Wong, D. A. |
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N/A |
Development of cell-free platforms for discovering, characterizing, and engineering post-translational modifications |
| 呼吸暂停突显了小鼠的睡眠结构 |
Casali, G. |
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N/A |
Respiratory pauses highlight sleep architecture in mice |
| 通过物种相互作用在生物多样性实验中划分生态系统生产力的变化 |
Tao, J. |
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N/A |
Partitioning changes in ecosystem productivity by effects of species interactions in biodiversity experiments |
| ROS诱导的压力促进抗生素抗性在传统活性污泥工艺中的富集和出现 |
Manna, B. |
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ROS-Induced Stress Promotes Enrichment and Emergence of Antibiotic Resistance in Conventional Activated Sludge Processes |
| RuBisCO的进化动力学：小亚基的出现及其随时间的演变影响 |
Amritkar, K. |
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Evolutionary Dynamics of RuBisCO: Emergence of the Small Subunit and its Impact Through Time |
| 撤回：揭示亲炎性巨噬细胞在先兆子痫母胎界面免疫网络失衡中的关键作用 |
Fei, H. |
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WITHDRAWN: Unveiling the Crucial Role of Pro-inflammatory Macrophages in the Immune Network Imbalance of the maternal-fetal interface with Preeclampsia |
| 溶酶体信号通路影响心脏节律，并调节心房功能。 |
Capel, R. A. |
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N/A |
Lysosomal signalling pathways influence heart rhythm, and regulate atrial function |
| 多组学分析与机器学习预测：在存在配子和胚胎的情况下输卵管的反应 |
Finnerty, R. M. |
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N/A |
Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos |
| 成人颞叶新皮层第1层兴奋性突触小体的超微结构亚层特异性多样性 |
Rollenhagen, A. |
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Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex |
| 脂肪组织中的芳香化酶通过磷酸盐调节在雄性小鼠中发挥骨保护作用。 |
Ikedo, A. |
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N/A |
Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation |
| 果蝇（Drosophila melanogaster）中的化学配偶选择模仿 |
Mitchell, B. |
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Chemical mate choice copying in Drosophila melanogaster |
| 发现了一种新型鞭虫物种，即T. incognita，其在科特迪瓦患者中对阿苯达唑-伊维菌素治疗的敏感性较低，通过粪便DNA代谢条形码技术鉴定。 |
Venkatesan, A. |
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N/A |
Discovery of a novel Trichuris species, T. incognita, with low sensitivity to albendazole-ivermectin treatment in Cote d'Ivoire patients, identified through fecal DNA metabarcoding |
| 细胞分裂素作为系统信号，协调拟南芥的生殖努力。 |
Volkava, D. |
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N/A |
Cytokinin acts as a systemic signal coordinating reproductive effort in Arabidopsis |
| 一个动力学简单行走模型修正了恢复速率的定义 |
Hosseini-Yazdi, S.-S. |
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A Powered Simple Walking Model Modifies the Rate of Recovery Definition |
| 小鼠脑中七个kisspeptin能神经元群体的综合化学分型和性腺调控 |
Hernandez, V. S. |
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A comprehensive chemotyping and gonadal regulation of seven kisspeptinergic neuronal populations in the mouse brain |
| HIV-1 Vif破坏了动粒处的磷酸酶反馈调节，导致明显的伪中期停滞 |
Ghone, D. |
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HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest |
| 大西洋沟虾（Palaemon varians Leach, 1814）的蜕皮周期与刚毛发育（十足目：真虾下目：长臂虾科） |
Kim, K. |
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N/A |
Moult cycle and setal development of the Atlantic ditch shrimp Palaemon varians Leach, 1814 (Decapoda: Caridea: Palaemonidae) |
| 胆碱能信号对鸣禽的鸣唱前运动回路进行差异化调控，以稳定鸣唱。 |
Xu, N. |
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N/A |
Cholinergic signaling differentially regulates song premotor circuits to stabilize songs in songbirds |
| 人类CCR4-NOT全局调控基因表达，是一种新型逆转录转座子激活的沉默因子。 |
Kulkarni, S. |
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Human CCR4-NOT globally regulates gene expression and is a novel silencer of retrotransposon activation |
| 调控因子的反相聚集塑造基因爆发 |
Li, B. |
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Anti-phase clustering of regulatory factors shapes gene bursting |
| 化石多样化速率的明显时间尺度变化是由抽样偏差引起的。 |
Reijenga, B. R. |
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N/A |
Apparent timescaling of fossil diversification rates is caused by sampling bias |
| 海马结构中社会知识的自我中心锚定与调整 |
Rodriguez Aramendia, M. |
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Egocentric anchoring-and-adjustment of social knowledge in the hippocampal formation |
| 编码于自我扩增RNA中的广谱免疫抑制作用能够实现非细胞毒性、非免疫刺激性的可逆转基因表达。 |
Lim, T. K. Y. |
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Broad-spectrum immune suppression encoded inself-amplifying RNA enables non-cytotoxic, non-immunostimulatory, reversible transgene expression |
| 编码于自我扩增RNA中的广谱免疫抑制作用能够实现非细胞毒性、非免疫刺激性的可逆转基因表达。 |
Lim, T. K. Y. |
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Broad-spectrum immune suppression encoded in self-amplifying RNA enables non-cytotoxic, non-immunostimulatory, reversible transgene expression |
| 疟原虫裂殖子单细胞RNA测序揭示，寄生虫通过激活基因网络为进入红细胞做准备。 |
Piel, L. |
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N/A |
Single cell RNA-sequencing of malaria merozoites reveals that the parasite prepares for life within the red blood cell by activating a gene network |
| 撤回：来自登革病毒2型感染的血管内皮细胞的灭活条件培养基对上皮细胞愈合的影响：活细胞成像分析。 |
Hincapie, V. |
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N/A |
WITHDRAWN: Effect of inactivated conditioned media from DENV-2-infected endothelial cells on epithelial cell healing: live cell imaging analysis. |
| 芜菁黄化病毒颗粒的结构。读取穿透域是如何暴露在衣壳表面的？ |
Lai-Kee-Him, J. |
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N/A |
Structure of the turnip yellows virus particles. How is the readthrough domain exposed on the capsid surface? |
| 前膜和包膜蛋白对蜱传脑炎病毒结构、致病性和趋向性的影响 |
Rosendal, E. |
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N/A |
The influence of the pre-membrane and envelope proteins on structure, pathogenicity and tropism of tick-borne encephalitis virus |
| 非裂解性复制病毒递送IL15超级激动剂增强抗肿瘤免疫并延长胶质母细胞瘤生存期 |
Haddad, A. F. |
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N/A |
Non-lytic replicating viral delivery of an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma |
| 光流解析作为因果源分离：一种从光流中同时提取物体和自身运动信息的计算模型 |
Scherff, M. |
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N/A |
Flow parsing as causal source separation: A computational model for concurrent retrieval of object and self-motion information from optic flow |
| 细菌双组分信号传导网络中激酶和效应子信号传导逻辑的变化 |
Swingle, D. |
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N/A |
Variations in kinase and effector signaling logic in a bacterial two component signaling network |
| 大规模定量交联质谱技术揭示了细胞器、细胞和组织中蛋白质构象可塑性的新见解 |
Keller, A. |
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N/A |
Large-Scale Quantitative Cross-Linking and Mass Spectrometry Provides New Insight on Protein Conformational Plasticity within Organelles, Cells, and Tissues |
| SARM1激活通过两步液-固相变促进轴突退化 |
Zhang, W. |
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SARM1 Activation Promotes Axonal Degeneration Via a Two-Step Liquid-to-Solid Phase Transition |
| 网格蛋白通过共同维持高尔基体的结构-功能关系来支持细胞外基质分泌。 |
Thompson, G. |
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N/A |
Golgins support extracellular matrix secretion by collectively maintaining the Golgi structure-function relationship |
| 溶组织内阿米巴中富含谷氨酸-赖氨酸（EK）的RabD2基序通过自相互作用及多泡体途径调控病原体的发病机制 |
Navyaka, P. |
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N/A |
Glutamic acid-lysine (EK) rich motif of RabD2 self-associates and regulates pathogenesis through multivesicular bodies pathway in E. histolytica |
| ALS和FTD相关蛋白Annexin A11和CHMP2B在膜修复中依次发挥作用 |
Heffner, C. M. |
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The ALS- and FTD-associated proteins Annexin A11 and CHMP2B act sequentially in membrane repair |
| 迈向鲁棒机器嗅觉：去偏GC-MS数据提升前列腺癌从尿液挥发性物质中的诊断 |
Rotteveel, A. |
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N/A |
Towards robust machine olfaction: debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles |
| 细菌类泛素蛋白的结构多样性与寡聚化 |
Gong, M. |
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N/A |
Structural diversity and oligomerization of bacterial ubiquitin-like proteins |
| 微生物物种树重建的系统评估方法 |
Weiner, S. |
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N/A |
A systematic assessment of phylogenomic approaches for microbial species tree reconstruction |
| Ezh2在正常小脑颗粒神经元发育过程中延迟分化基因的激活，并在髓母细胞瘤中发挥类似作用。 |
Purzner, J. |
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N/A |
Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma |
| 在一种分化的细菌泛素化途径中蛋白质共轭的机制基础 |
Ye, Q. |
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N/A |
Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway |
| 计算分析以评估降主动脉瘤中的血流动力学力 |
Duca, F. |
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N/A |
Computational analysis to assess hemodynamic forces in descending thoracic aortic aneurysms |
| 在非常罕见的祖B细胞条件下，多样化的启动结果 |
Madden, P. J. |
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N/A |
Diverse priming outcomes under conditions of very rare precursor B cells |
| 成对相互作用和连续瓶颈效应有助于解释多物种微生物群落中的物种组成 |
Lele, K. |
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N/A |
Pairwise interactions and serial bottlenecks help explain species composition in a multi-species microbial community |
| 具有两种不同DNA结合模式的保守ComP结构——使用AlphaFold3、RoseTTAFold2NA、Chai-1进行系统建模及在HADDOCK中重新对接 |
Helsem, S. A. |
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N/A |
The conserved ComP structure with two distinct DNA binding modes - systematic modeling with AlphaFold3, RoseTTAFold2NA, Chai-1 and re-docking in HADDOCK |
| 一种偏好腺嘌呤碱基编辑器，具有最小的旁观者效应和脱靶编辑 |
Shang, M. |
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N/A |
A motif preferred adenine base editor with minimal bystander and off-targets editing |
| 抗生素治疗和微生物群减少会减缓刺胞动物的再生过程。 |
Da-Anoy, J. |
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N/A |
Antibiotic treatment and microbiome depletion slow cnidarian regeneration |
| 网络共同体：连接数据、知识和方法，构建和评估特定情境下的生物网络 |
Paton, V. |
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N/A |
NetworkCommons: bridging data, knowledge and methods to build and evaluate context-specific biological networks |
| 复制压力标志物磷酸化-RPA2预测同源重组功能正常的卵巢癌对铂类和PARP抑制剂的反应 |
Schab, A. |
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N/A |
Replication stress marker phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer |
| 乙型肝炎核心相关抗原在既往乙型肝炎病毒感染患者病毒基因组整合中的作用 |
Saito, T. |
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N/A |
Involvement of Hepatitis B Core-Related Antigen in Viral Genome Integration in Patients With Prior Hepatitis B Virus Infection |
| S-1生物标志物对接受辅助S-1化疗的老年肺癌患者衰老和预后的影响：Setouchi肺癌研究组1201研究的伴随结果 |
Soh, J. |
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N/A |
Implication of S-1 biomarkers on aging and prognosis in elderly patients with lung cancer treated by adjuvant S-1 chemotherapy: Accompanying results of the Setouchi Lung Cancer Group Study 1201 |
| 细胞代谢通量分布的深度学习预测寿命 |
Hilsabeck, T. A. |
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N/A |
Deep Learning of Cellular Metabolic Flux Distributions Predicts Lifespan |
| 多巴胺在有无反馈的情况下都会影响运动学习表现。 |
Leow, L.-A. |
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N/A |
Dopamine alters motor learning performance in the presence and absence of feedback |
| GRNIX：一种基于图神经网络的可解释基因调控网络推断框架，用于自身免疫性疾病中的XAI |
Manai, M. M. |
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N/A |
GRNIX: A Graph Neural Network Framework for Explainable Gene Regulatory Network Inference in Autoimmune Diseases Using XAI |
| 改进的深度学习预测TCR-HLA关联 |
Li, F. |
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N/A |
Improved Deep Learning Prediction of TCR-HLA Association |
| 间隙DNA的序列依赖性液晶有序化 |
Kodikara, S. |
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N/A |
Sequence-Dependent Liquid Crystalline Ordering of Gapped DNA |
| 高度有序脂质双层中玻璃态动力学的特征及软动态通道的出现 |
Sureshkumar, H. |
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N/A |
Signatures of glassy dynamics in highly ordered lipid bilayers with emergence of soft dynamic channels |
| 基于荧光技术的活细胞成像识别出跳过第14外显子的肝细胞生长因子受体（MET）降解剂 |
Mallareddy, J. R. |
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N/A |
Fluorescence based live cell imaging identifies exon 14 skipped hepatocyte growth factor receptor (MET) degraders |
| 中国上二叠统闹包沟组四足动物群：一种新的中型前棱蜥类——阴山龙属新种阴山龙及其对前棱蜥类系统发育关系的启示 |
Yi, J. |
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N/A |
The tetrapod fauna of the upper Permian Naobaogou Formation of China: a new mid-sized pareiasaur Yinshanosaurus angustus gen. et sp. nov. and its implication for the phylogenetic relationship of pareiasaurs |
| TGFbeta-LRRC15轴的关键调控元件预测了多种癌症类型的疾病进展及免疫治疗抵抗 |
Storey, C. M. |
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N/A |
Key Regulatory Elements of the TGFbeta-LRRC15 Axis Predict Disease Progression and Immunotherapy Resistance Across Cancer Types |
| 玉米黑粉菌（Ustilago maydis）通过破坏宿主细胞中的碳水化合物信号网络来诱导细胞肥大。 |
Lee, Y. J. |
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N/A |
Ustilago maydis disrupts carbohydrate signaling networks to induce hypertrophy in host cells |
| 适应性生物系统的累积剂量反应 |
Gupta, A. |
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N/A |
Cumulative dose responses for adapting biological systems |
| 鱼类微小RNA对热应激的响应：全球变暖背景下对水产养殖与保护的启示与影响 |
Lin, T. |
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N/A |
Fish MicroRNA Responses to Thermal Stress: Insights and Implications for Aquaculture and Conservation Amid Global Warming |
| 大脑-网格模型：神经同步、可塑性和一致性的统一框架 |
Ballus, A. |
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N/A |
THE BRAIN-MESH MODEL: A UNIFIED FRAMEWORK FORNEURAL SYNCHRONY, PLASTICITY, AND COHERENCE |
| 人类大脑区域脑熵（BEN）的细胞类型基础 |
Song, D. |
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N/A |
The cell-type underpinnings of regional brain entropy (BEN) in human brain |
| 通过纵向分子亚型分析揭示SARS-CoV-2宿主反应的异质性 |
Wang, K. |
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N/A |
Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping |
| 唐氏综合征中失调的气道上皮抗病毒免疫削弱了III型干扰素反应，并在呼吸道合胞病毒感染期间加剧了气道炎症。 |
Chorvinsky, E. |
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N/A |
Dysregulated airway epithelial antiviral immunity in Down Syndrome impairs type III IFN response and amplifies airway inflammation during RSV infection. |
| 肠道损伤的新型免疫标志物，指示HIV-1状态和/或亚临床动脉粥样硬化 |
Moreira Gabriel, E. |
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N/A |
Novel Immunological Markers of Intestinal Impairment Indicative of HIV-1 Status and/or Subclinical Atherosclerosis |
| Bin Chicken：针对目标宏基因组共组装，高效恢复新颖基因组 |
Aroney, S. T. N. |
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N/A |
Bin Chicken: targeted metagenomic coassembly for the efficient recovery of novel genomes |
| RetS通过感知神经递质去甲肾上腺素和肾上腺素来调节铜绿假单胞菌的毒力。 |
Zhou, Y. |
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N/A |
RetS senses neurotransmitter norepinephrine and adrenergic agents to regulate Pseudomonas aeruginosa virulence |
| 益生菌搅拌酸奶对大鼠代谢功能障碍相关脂肪肝疾病的预防作用 |
Sallam, M. S. |
PDF |
N/A |
Probiotic Stirred Yogurt Mediated the Prevention of Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats |
| 在GKAP支架蛋白与LC8枢纽蛋白之间拓扑约束的多价复合物中，存在残余的灵活性。 |
Nagy-Kanta, E. |
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N/A |
Residual flexibility in the topologically constrained multivalent complex between the GKAP scaffold and LC8 hub proteins |
| 细菌硫辛酰胺蛋白连接酶在哺乳动物中拯救硫辛酰化及呼吸缺陷 |
Hu, Z. |
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N/A |
Bacterial lipoate protein ligases rescue lipoylation and respiration deficiency in mammals |
| 全球微型浮游生物生物地理分布通过宏基因组和气候数据整合揭示 |
Salazar, V. W. |
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N/A |
Global picoplankton biogeography revealed by metagenomic and climatic data integration |
| 委内瑞拉三种空中捕食蝙蝠的饮食及其生态位划分 |
Azofeifa Romero, Y. |
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N/A |
Diet and trophic niche partitioning of three aerial hawking bat species in Venezuela |
| 使用堆叠模型和物种特征预测食物网中的缺失链接 |
Van Kleunen, L. B. |
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N/A |
Predicting missing links in food webs using stacked models and species traits |
| 基于三联体（triplet）的物种树估算方法对基因树根节点（或其缺失）的鲁棒性 |
Zaman, T. A. |
PDF |
N/A |
On the robustness to gene tree rooting (or lack thereof) of triplet-based species tree estimation methods |
| 单花蝇子草的染色体规模基因组组装和连锁图谱揭示了快速进化植物物种的重组景观 |
Osborne, O. G. |
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N/A |
Chromosome-scale genome assembly and linkage map for Silene uniflora reveal the recombination landscape in a rapidly evolving plant species |
| 果蝇（Drosophila melanogaster）中高度转录且具有性别偏向基因的非最优密码子选择的证据 |
Whittle, C. A. |
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N/A |
Evidence for non-optimal codon choice in highly transcribed sex-biased genes of Drosophila melanogaster |
| 综合方法优先考虑孤儿GPR61基因组区域在组织特异性调节生物钟类型中的作用 |
Tchio, C. |
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N/A |
An integrative approach prioritizes the orphan GPR61 genomic region in tissue-specific regulation of chronotype |
| 肌萎缩侧索硬化症中的性别特异性DNA甲基化差异 |
Grant, O. |
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N/A |
Sex-specific DNA methylation differences in Amyotrophic lateral sclerosis |
| 潜在抑制、发散思维与目击记忆的关系：一项关于对无关刺激注意的研究 |
Badiola-Lekue, I. |
PDF |
N/A |
The Relationship between Latent Inhibition, Divergent Thinking, and Eyewitness Memory: A Study on Attention to Irrelevant Stimuli |
| 通过活性位点半胱氨酸对SARS-CoV-2 NiRAN结构域进行共价抑制 |
Hernandez, G. |
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N/A |
Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine |
| 印楝油纳米乳剂对人类神经母细胞瘤SH-SY5Y细胞系中由淀粉样β1-40诱导的抗阿尔茨海默病效应 |
Govindaswamy, B. |
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N/A |
Anti Alzheimer's effects of Neem oil nanoemulsion against Amyloid β1-40 induced in human neuroblastoma SH-SY5Y cell line |
| 兔心生物人工组织：灌注去细胞化与特性分析 |
Seitzhaparova, B. |
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N/A |
Rabbit Heart Bioartificial Tissue: Perfusion Decellularization and Characterization |
| 评估用于病毒基因组学的长读长映射工具 |
Baudeau, T. |
PDF |
N/A |
Assessing Long-Read Mappers for Viral Genomics |
| CNV-Profile回归：一种新的全基因组测序数据拷贝数变异关联分析方法 |
Si, Y. |
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N/A |
CNV-Profile Regression: A New Approach for Copy Number Variant Association Analysis in Whole Genome Sequencing Data |
| 解剖区域特异性转录组特征及上皮细胞在翼状胬肉炎症中的作用：一项多组学分析 |
Song, C. |
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N/A |
Anatomical Region-Specific Transcriptomic Signatures and the Role of Epithelial Cells in Pterygium Inflammation: A Multi-Omics Analysis |
| 利用眼动持续同调性进行神经障碍筛查 |
He, D. |
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N/A |
Leveraging Persistent Homology of Eye Movements for Neural Disorder Screening |
| 通过计算机模拟和RBP结合的解释，揭示了m6A-RBP相互作用 |
Liu, J. |
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N/A |
In-silico modeling and interpretation of RBP binding disentangle m6A-RBP interaction |
| 用于通过光学控制跨膜离子通信的开关纳米孔 |
Wang, X. |
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N/A |
ON-OFF nanopores for optical control of transmembrane ionic communication |
| Tau聚集受其投影域突变的影响而发生改变 |
Mason-Chalmers, K. |
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N/A |
Tau Aggregation is Altered by Mutations in its Projection Domain |
| 腹水可防止铁死亡并促进卵巢癌的腹腔扩散 |
Setayeshpour, Y. |
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N/A |
Ascitic fluid protects against ferroptosis and enables the peritoneal spread of ovarian cancer |
| FAK抑制通过DNA甲基化介导的DAB2基因重新激活抑制乳腺癌进展 |
Lim, S. |
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N/A |
FAK inhibition suppresses breast cancer progression via DNA methylation-mediated DAB2 gene reactivation |
| 抑制Wnt通路效应因子TCF7L2可逆转小鼠肠道癌症中的致命恶病质 |
Leong, M. L. |
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N/A |
Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers |
| 定量磁共振成像测量捕捉到胰腺癌和基质对新型KRAS抑制剂的反应 |
Gupta, M. |
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N/A |
Quantitative MRI Measurements Capture Pancreatic Cancer and Stroma Reactions to New KRAS Inhibitor |
| 豌豆白粉菌（Erysiphe pisi）是一种专性寄生真菌，主要感染豌豆（Pisum sativus）和扁豆（Lathyrus sativus）。扁豆是一种重要的粮食和饲料作物，在亚洲和非洲部分地区广泛种植。然而，扁豆对豌豆白粉菌的抗性因品种而异，这限制了其在这些地区的可持续种植。为了更好地了解扁豆对豌豆白粉菌的抗性机制，我们进行了比较转录组学分析，比较了两个扁豆品种（Ls-1和Ls-2）在接种豌豆白粉菌后的转录组变化。我们发现，两个品种在接种豌豆白粉菌后表现出不同的转录组响应，表明它们对病原体的抗性机制存在差异。具体而言，Ls-1品种在接种豌豆白粉菌后上调了多个与防御相关的基因，包括几丁质酶、β-1,3-葡聚糖酶和抗病蛋白基因，而Ls-2品种则没有表现出类似的上调。此外，我们还发现Ls-1品种在接种豌豆白粉菌后下调了多个与生长和发育相关的基因，这可能有助于将资源重新分配给防御反应。我们的研究结果表明，扁豆对豌豆白粉菌的抗性是一个复杂的性状，涉及多个基因和途径的调控。未来的研究应进一步探索这些基因和途径在扁豆抗病性中的作用，以开发更有效的抗病品种。 |
Marques, R. M. |
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N/A |
Comparative transcriptomics of Lathyrus sativus reveals accession-specific resistance responses against Erysiphe pisi |
| 通过综合生态基因组学揭示全球栗树害虫入侵的由下而上和由上而下的控制机制 |
Zitoun, J.-l. |
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N/A |
Unravelling the bottom-up and top-down control of a worldwide chestnut tree pest invader through integrative ecological genomics |
| 细胞通过进入一种类似静止的状态，以高效率转化为神经元。 |
Beitz, A. M. |
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N/A |
Cells transit through a quiescent-like state to convert to neurons at high rates |
| 三级淋巴结构作为克罗恩病治疗靶点：TNFα阻断剂的调节作用 |
Nagase, Y. |
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N/A |
Tertiary lymphoid structure as a therapeutic target of Crohns disease: modulation by TNFα blockade |
| 利用受激辐射损耗显微技术揭示活体白色念珠菌的超微结构 |
Baxter, K. J. |
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N/A |
Revealing the Ultrastructure of Live Candida albicans using Stimulated Emission Depletion Microscopy |
| 深海冷泉中的微生物毒力组和抗性组对公共健康构成的风险极小。 |
Zhang, T. |
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N/A |
Microbial virulome and resistome in deep-sea cold seeps pose minimal public health risks |
| SARS-CoV-2 nsp1中自然发生的N端突变影响先天免疫调节，但不影响病毒毒力 |
Rani, R. |
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N/A |
Naturally occurring N-terminal mutations in SARS-CoV-2 nsp1 impact innate immune modulation but do not affect virus virulence |
| 慢性感染SARS-CoV-2患者体内遗传多样性的多种模式 |
Rutsinsky, N. |
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N/A |
Diverse patterns of intra-host genetic diversity in chronically infected SARS-CoV-2 patients |
| 多个线虫物种在整个神经系统中进化变化的分子模式 |
Toker, I. A. |
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N/A |
Molecular patterns of evolutionary changes throughout the whole nervous system of multiple nematode species |
| 解决斑纹蟾蜍（Bufonidae: Incilius marmoreus）的分类地位：基于2RAD的系统地理学研究，包括墨西哥韦拉克鲁斯州的一个孤立种群 |
Wang, K. |
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N/A |
Resolving the Taxonomic Status of the Marbled Toad (Bufonidae: Incilius marmoreus): 2RAD-based Phylogeography Including an Isolated Population in Veracruz, Mexico |
| 多个性状的协同进化使蝴蝶拥有了一个假头 |
Yumnam, T. |
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N/A |
Correlated evolution of multiple traits gives butterflies a false head |
| 全基因组关联研究确定了冬季和早春耐寒性的有希望的QTL，作为深入遗传分析和在冬蚕豆（Vicia faba L.）育种中实施的基础。 |
Windhorst, A. |
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N/A |
Genome-wide association studies identify promising QTL for freezing tolerance in winter and early spring as a basis for in-depth genetic analysis and implementation in winter faba bean (Vicia faba L.) breeding |
| 一种用于评估应用于野生海洋鱼类的基因组动物模型鲁棒性的新框架 |
Thia, J. A. |
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N/A |
A novel framework for assessing the robustness of genomic animal models applied to a wild marine fish |
| 苏门答腊猩猩母亲在母性行为的表现程度和轨迹上存在差异。 |
Revathe, T. |
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N/A |
Sumatran orangutan mothers differ in the extent and trajectory of their expression of maternal behaviour |
| 斑胸草雀社会网络多层结构的社会和空间驱动因素 |
Zhang, Y. |
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N/A |
Social and spatial drivers of the multitiered structure of zebra finch social networks |
| 对下丘脑表型的调查确定了雄性和雌性小鼠中MYT1L单倍体不足的分子和行为后果。 |
Dougherty, J. D. |
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N/A |
A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice. |
| 狐獴中的发声修饰：弱联结的从属者对支配者的回应中发出更多的叫声 |
Demartsev, V. |
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N/A |
Vocal grooming in meerkats: weakly bonded subordinatescall more in response to dominants |
| 衰老对黑猩猩使用石器工具的参与度和效率的影响因个体而异。 |
Howard-Spink, E. |
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N/A |
Old age variably impacts chimpanzee engagement and efficiency in stone tool use |
| 在体外高保真地将多种合成货物包装到封装蛋白笼中 |
Szyszka, T. N. |
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N/A |
High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages |
| 肝细胞癌的综合转录组分析：揭示不同病因中的共享与独特分子特征 |
Khorsand, B. |
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N/A |
Comprehensive Transcriptomic Analysis of Hepatocellular Carcinoma: Uncovering Shared and Unique Molecular Signatures Across Diverse Etiologies |
| 洛伦兹对基因集富集分析的看法：基因集富集分析与财富不平等衡量方法的相似性与差异 |
Pagnotta, S. M. |
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N/A |
The Lorenz's side of Gene Set Enrichment Analysis: Similarity and divergences of the Gene Set Enrichment Analysis from the measure of wealth inequality |
| NhaA中Na+/H+反向转运的分子机制 |
Xie, T. |
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N/A |
Molecular mechanism of Na+/H+ antiporting in NhaA |
| 雌激素受体信号转录程序与人类激素受体阳性乳腺癌中的免疫逃逸相关 |
Shimada, K. |
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N/A |
An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer |
| 同时抑制COX-1和COX-2不足以引发与长期使用非甾体抗炎药（NSAID）相关的肠病。 |
Barekat, K. |
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N/A |
Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use |
| 氧化性损伤对肺线粒体DNA是化学性肺损伤发展的关键因素 |
Dubey, S. |
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N/A |
Oxidative Injury to Lung Mitochondrial DNA is a Key Contributorfor the Development of Chemical Lung Injury |
| 可可基因组序列揭示了黄酮类生物合成的见解 |
Marin Recinos, M. F. |
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N/A |
Cacao genome sequence reveals insights into the flavonoid biosynthesis |
| DNA复制时序揭示了转录和脆弱性的全基因组特征 |
Berkemeier, F. |
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N/A |
DNA replication timing reveals genome-wide features of transcription and fragility |
| 评估单细胞基因表达动力学对联合抗生素生存能力的预测能力 |
Alnahhas, R. N. |
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N/A |
Evaluating the predictive power of combined gene expression dynamics from single cells on antibiotic survival |
| 区域特异性图片命名受益于焦点tDCS的效果取决于老年人的基线表现 |
Yucel, A. |
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N/A |
Regionally specific picture naming benefits of focal tDCS are dependent on baseline performance in older adults |
| 同种社交性受联想学习回路调节。 |
Lobato-Rios, V. |
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N/A |
Conspecific sociability is regulated by associative learning circuits |
| 叶酸可预防草原田鼠因发育期接触拟除虫菊酯而导致的自闭症相关表型。 |
Saferin, N. |
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N/A |
Folate prevents the autism-related phenotype caused by developmental pyrethroid exposure in prairie voles |
| 鼻内丹曲洛林纳米颗粒抑制5XFAD小鼠脑内炎症性细胞焦亡 |
Bhuiyan, P. |
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N/A |
Intranasal dantrolene nanoparticles inhibit inflammatory pyroptosis in 5XFAD mice brains |
| Parp1缺失可挽救xrcc1突变斑马鱼的小脑发育不良 |
Semenova, S. A. |
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N/A |
Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish |
| 使用基于定量MRI的水参考的2D 1H-MRSI对脑代谢物进行绝对定量 |
Thomas, D. C. |
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N/A |
Absolute quantification of cerebral metabolites using 2D 1H-MRSI with quantitative MRI-based water reference |
| 一种多用途的鼠标模型，用于推进神经退行性疾病中人源小胶质细胞移植研究 |
De Strooper, B. |
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N/A |
A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases |
| 基于多模态、多方面的成像人类大脑白质图谱 |
Zhou, J. |
PDF |
N/A |
Multimodal, multifaceted Imaging-based Human Brain White Matter Atlas |
| 虚拟大脑将经颅磁刺激引发的电位与重度抑郁症中抑制性神经递质的变化联系起来。 |
Hofsähs, T. |
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N/A |
The Virtual Brain links transcranial magnetic stimulation evoked potentials and inhibitory neurotransmitter changes in major depressive disorder |
| 直观的物理推理并不通过语言进行中介，也不是仅依赖于领域通用的抽象表征。 |
Kean, H. H. |
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N/A |
Intuitive physical reasoning is not mediated by linguistic nor exclusively domain-general abstract representations |
| 使用量子点和去卷积技术的快速光稳定扩展显微镜 |
Gunawardhana, L. |
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N/A |
Fast Photostable Expansion Microscopy Using QDots andDeconvolution |
| 通过计算建模揭示了人类和猴子对三维和运动刺激的不同决策过程 |
Rangotis, R. |
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N/A |
Distinct decision processes for 3D and motion stimuli in both humans and monkeys revealed by computational modelling |
| 增加的不情愿囊泡通过GPR55在小脑浦肯野细胞轴突末梢中导致突触抑制 |
Inoshita, T. |
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N/A |
Increased reluctant vesicles underlie synaptic depression by GPR55 in axon terminals of cerebellar Purkinje cells |
| CRISPRa介导的2C样状态、全能性和细胞死亡中Dux-MERVL轴的解离 |
Chammas, P. |
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N/A |
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency and cell death |
| 糖基转移酶POGLUT1调控小鼠肌肉干细胞的发育和维持 |
Cho, S. |
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N/A |
The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice |
| 全面蛋白质组学、超微结构及功能分析：低温保存对海洋贻贝卵细胞的影响 |
Blanco, S. |
PDF |
N/A |
Comprehensive Proteomic, Ultrastructural and Functional Analysis of Cryopreservation Effects on Marine Mussel Oocytes |
| 城市化对芝加哥地区美洲知更鸟（Turdus migratorus）健康的影响 |
Riccardi, A. |
PDF |
N/A |
Impacts of urbanization on the health of American Robins (Turdus migratorus) in Chicagoland |
| 测试蜜蜂的峰终法则：当最终奖励令人失望时，蜜蜂对高奖励序列缺乏偏好 |
Armand, M. |
PDF |
N/A |
Testing the peak-end rule in bumblebees: lack of preference for a higher-reward sequence when the final reward is disappointing |
| 雌性小鼠超声波发声的频率较低，在与无声雄性互动时，其发声频率并不受发情状态的影响。 |
Malone, C. A. |
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N/A |
Rates of female mouse ultrasonic vocalizations are low and are not modulated by estrous state during interactions with muted males |
| 脊髓刺激模型中的频率依赖性和电容性组织电特性 |
Khadka, N. |
PDF |
N/A |
Frequency-dependent and capacitive tissue electrical properties in spinal cord stimulation models |
| ApoDock：用于柔性分子对接的配体条件侧链包装 |
Luo, D. |
PDF |
N/A |
ApoDock: Ligand-Conditioned Sidechain Packing for Flexible Molecular Docking |
| DeepAssembly2：基于域-域相互作用的蛋白质复合物结构组装网络服务器 |
Xia, Y. |
PDF |
N/A |
DeepAssembly2: A Web Server for Protein Complex Structure Assembly Based on Domain-Domain Interactions |
| 饥饿和荷尔蒙状态的整合调控着面向婴儿的攻击行为 |
Cao, M. |
PDF |
N/A |
Integration of hunger and hormonal state gates infant-directed aggression |
| 胚胎生成的中间神经元（EGINs）在嗅球中表现出独特的发展程序和分层结构。 |
Spence, N. J. |
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N/A |
Embryonically generated interneurons (EGINs) exhibit a distinctive developmental program and lamination in the olfactory bulb |
| H通道和m通道的过度表达通过损害抑制性神经元处理相关输入的能力，促进了类似癫痫事件的发生。 |
Rich, S. |
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N/A |
H- and m-channel overexpression promotes seizure-like events by impairing the ability of inhibitory neurons to process correlated inputs |
| 谷氨酰胺分解促进易患狼疮小鼠的滤泡辅助性T细胞功能 |
Choi, S. C. |
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N/A |
Glutaminolysis promotes the function of follicular helper T cells in lupus-prone mice |
| 从濒危的塔斯马尼亚恶魔（Sarcophilus harrisii）肿瘤细胞中分离出一种类似病毒的传染性哺乳动物病毒 |
Melade, J. |
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N/A |
Isolation of an infectious mammalian chu-like virus from tumor cells of the endangered Tasmanian devil (Sarcophilus harrisii) |
| 细菌菌落活检：通过细胞光谱指纹技术实现异质细胞类型的空间辨别 |
Abbaszade, G. |
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N/A |
Bacterial colony biopsies: spatial discrimination of heterogeneous cell types by cytometric fingerprinting |
| M66I衣壳变异体对Lenacapavir耐药的结构和机制基础 |
Briganti, L. |
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N/A |
Structural and Mechanistic Bases for Resistance of the M66I Capsid Variant to Lenacapavir |
| 毒力决定因子蛋白E是一种弗朗西斯菌VI型分泌系统效应蛋白，能够调节宿主细胞的死亡。 |
Adams, N. |
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N/A |
Pathogenicity determinant protein E is a Francisella type VI secretion system effector protein that modulates host death |
| 评估宽吻海龙（Syngnathus typhle）肠道微生物群组成中噬菌体的影响 |
Parker, J. |
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N/A |
Evaluating bacteriophage impact on gut microbiome composition in broad-nosed pipefish (Syngnathus typhle) |
| HsbA抑制铜绿假单胞菌静止期生物膜的形成。 |
Pulido Sanchez, M. |
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N/A |
HsbA represses stationary phase biofilm formation in Pseudomonas putida |
| Rigosertib可逆转与RAF1相关的努南综合征中的肥厚型心肌病 |
Legler, L. |
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N/A |
Rigosertib reverses hypertrophic cardiomyopathy in RAF1-associated Noonan syndrome |
| 从犬类脐带中非病毒诱导的多能干细胞的衍生 |
Yamazaki, A. |
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N/A |
Non-viral derivation of induced pluripotent stem cells from the canine umbilical cord |
| 内耳神经元的脱离时间决定了它们的空间分布和目标神经支配。 |
Saini, S. S. J. S. |
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N/A |
Timing of delamination of inner ear neurons specifies their topography and target innervation |
| 入侵型黄蜂Vespa velutina nigrithorax比另外两种膜翅目昆虫——普通黄蜂Vespa vulgaris和蜜蜂Bombus terrestris——更容易受到昆虫病原真菌的感染。 |
Lacombrade, M. |
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N/A |
Invasive Vespa velutina nigrithorax hornets are more susceptible to entomopathogenic fungus than two other hymenopteran species, the wasp Vespa vulgaris and the bumblebee Bombus terrestris. |
| 结构泛素有助于HECT连接酶Tom1的K48连接特异性 |
Warner, K. |
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Structural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1 |
| RalGAP肿瘤抑制复合物的结构与机制 |
Rasche, R. |
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N/A |
Structure and mechanism of the RalGAP tumor suppressor complex |
| 胆固醇在人类平滑受体中的感知和转运的能量学 |
Bansal, P. D. |
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N/A |
Energetics of cholesterol perception and translocation in the human Smoothened receptor |
| E3泛素连接酶TRIP12对氧化应激反应的动态调控 |
Ingersoll, A. J. |
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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12 |
| 接触图拓扑对RNA结构预测的影响 |
Faber, C. |
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Influence of Contact Map Topology on RNA Structure Prediction |
| 一种多功能的反CRISPR平台，用于光遗传学和化学遗传学控制广泛同源物中的CRISPR-Cas9和Cas12 |
Brenker, L. |
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A Versatile Anti-CRISPR Platform for Opto- and Chemogenetic Control of CRISPR-Cas9 and Cas12 across a Wide Range of Orthologs |
| 利用两阶段透明机器学习模型进行超高通量抗菌联合疗法筛选 |
Reuter, M. M. |
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N/A |
Ultra-high-throughput screening of antimicrobial combination therapies using a two-stage transparent machine learning model |
| 特异性导航决定了多隔间环境中鼠标CA1的表征结构 |
Pecirno, S. A. |
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N/A |
Idiosyncratic navigation determines mouse CA1 representational structure in a multicompartment environment |
| CRISPRi筛选揭示了lncRNA调控人类单核细胞生长的机制 |
Flores-Arena, C. |
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N/A |
CRISPRi Screen Uncovers lncRNA Regulators of Human Monocyte Growth |
| 糖细菌部署了两种不同的IV型菌毛，推动了共生、宿主竞争和滑行运动。 |
Grossman, A. S. |
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N/A |
Saccharibacteria deploy two distinct Type IV pili, driving episymbiosis, host competition, and twitching motility |
| 分泌性白细胞蛋白酶抑制剂影响伯氏疏螺旋体感染小鼠的关节周围炎症 |
Yu, Q. |
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N/A |
Secretory leukocyte protease inhibitor influences periarticular joint inflammation in B. burgdorferi-infected mice |
| 结核分枝杆菌中一种新型放线菌特异性核糖体休眠因子 |
Majumdar, S. |
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N/A |
A Novel Actinobacteria-Specific Ribosome Hibernation Factor in Mycobacterium tuberculosis |
| 温度，而非植物品种，影响杀虫双链RNA在科罗拉多马铃薯甲虫中的效果。 |
Darrington, M. |
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N/A |
Temperature, but not plant cultivar, influence the efficacy of insecticidal dsRNA in Colorado potato beetle |
| RNF20介导的H2B单泛素化保护停滞的复制叉并促进复制叉重启 |
Nagaraju, G. |
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RNF20-mediated H2B monoubiquitination protects stalled forks and promotes fork restart |
| 肾皮质细胞特异性氧化代谢 |
Feola, K. |
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N/A |
Cell-specific oxidative metabolism of the renal cortex |
| iPSC衍生的肾脏类器官和管状模型比较分析 |
Nunez Nescolarde, A. |
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Comparative analysis of iPSC-derived human kidney organoid and tubuloid models |
| 通过针对宿主特异性引物设计实现内生真菌的有效扩增子测序，适用于纳米孔长读长测序 |
He, T. |
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Effective metabarcoding of endophytic fungi through host-exclusive primer design for nanopore long-read sequencing |
| 太平洋牡蛎OSHV-1抗性标记存在于第8号染色体上，并不影响其对河口弧菌感染的易感性。 |
Surry, L. B. |
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The presence of the Pacific Oyster OSHV-1 resistance marker on chromosome 8 does not impact susceptibility to infection by Vibrio aestuarianus |
| 基于Tiled PCR扩增的全基因组测序与系统发育分类加速了呼吸道合胞病毒基因组监测在加拿大的实施，作为一项试点研究 |
Gao, R. |
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Tiled PCR amplification-based Whole Genome Sequencing and Phylogenetic Classification Accelerate the Implementation of Respiratory Syncytial Virus Genomic surveillance in Canada as a Pilot Study |
| 聚集蛋白聚糖的透明质酸结合活性对其特异性插入神经元周围网（perineuronal nets）是重要的，但并非必要条件。 |
Otsuka, M. Y. |
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The hyaluronan-binding activity of aggrecan is important, but not essential, for its specific insertion into perineuronal nets |
| 解析真菌中III型聚酮合酶的功能多样性 |
Sokolova, N. |
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N/A |
Unravelling the functional diversity of type III polyketide synthases in fungi |
| 利用生成式人工智能设计新型CAR-T细胞疗法 |
Mergen, M. |
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N/A |
Engineering de novo binder CAR-T cell therapies with generative AI |
| mei-P26突变体的功能缺失性分析揭示了发育过程中CO模式机制的调控 |
Berent, E. |
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Analysis of a hypomorphic mei-P26 mutation reveals developmental control of CO patterning mechanisms |