| 全基因组CRISPR筛选识别出由LRRK2调控的人类神经元摄取细胞外tau的途径 |
Evans, L. D. |
PDF |
N/A |
Whole genome CRISPR screens identify a LRRK2-regulated pathway for extracellular tau uptake by human neurons |
| 一个长达二十年的淡水湖泊微生物时间序列，介绍了limony和TYMEFLIES数据集。 |
Rohwer, R. R. |
PDF |
N/A |
A two-decade microbial time series from a freshwater lake, introducing the limony and TYMEFLIES datasets |
| 一种新的先验实用可辨识性方法 |
Thompson, P. A. |
PDF |
N/A |
A new method for a priori practical identifiability |
| 在清醒状态下通过致幻剂5-MeO-DMT诱导小鼠进入类似睡眠的状态 |
Breant, B. J. |
PDF |
N/A |
Sleep-like state during wakefulness induced by psychedelic 5-MeO-DMT in mice |
| 非转基因动物中非侵入性光学合成听觉感觉 |
Tamai, Y. |
PDF |
N/A |
Non-invasive optical synthetization of hearing sensation in non-genetically modified animal |
| 内胚层细胞通过运动接触抑制来实现斑马鱼原肠胚形成期间均匀的细胞分散。 |
LaBelle, J. |
PDF |
N/A |
Endodermal cells use contact inhibition of locomotion to achieve uniform cell dispersal during zebrafish gastrulation |
| 亲吻素纤维及其受体分布分析表明其在中枢感觉处理和行为状态控制中的潜在作用 |
Zhang, L. |
PDF |
N/A |
Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control |
| ATP爆发是耻垢分枝杆菌抗生素致死性的主要驱动力。 |
Lodhiya, T. |
PDF |
N/A |
ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis |
| 系统性4-1BB刺激在疟原虫感染期间增强了滤泡外记忆B细胞的形成和回忆反应。 |
Caloba, C. |
PDF |
N/A |
Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection. |
| bamSliceR：一个用于快速跨队列变异分析的Bioconductor包 |
Huang, Y. P. |
PDF |
N/A |
bamSliceR: a Bioconductor package for rapid, cross-cohort variant analysis |
| GFETM：基于基因组基础的嵌入式主题模型用于单细胞ATAC-seq建模 |
Fan, Y. |
PDF |
N/A |
GFETM: Genome Foundation-based Embedded Topic Model for scATAC-seq Modeling |
| 单分子直接RNA测序揭示了跨多个物种的表观转录组塑造 |
Xie, Y.-Y. |
PDF |
N/A |
Single-Molecule Direct RNA Sequencing Reveals the Shaping of Epitranscriptome Across Multiple Species |
| 利用适应度景观建模和强化学习加速蛋白质工程 |
Sun, H. |
PDF |
N/A |
Accelerating protein engineering with fitness landscape modeling and reinforcement learning |
| 细胞壁重塑和囊泡产生的维持在结核分枝杆菌中是相互关联的。 |
Salgueiro, V. |
PDF |
N/A |
Maintenance of cell wall remodeling and vesicle production are connected in Mycobacterium tuberculosis |
| 干扰抑制仅在视网膜坐标中运作。 |
Ilksoy, Y. A. |
PDF |
N/A |
Distractor suppression operates exclusively in retinotopic coordinates |
| Voronota-LT：高效、灵活且考虑溶剂的基于镶嵌分析的原子相互作用 |
Olechnovic, K. |
PDF |
N/A |
Voronota-LT: efficient, flexible and solvent-aware tessellation-based analysis of atomic interactions |
| 利用农畜的表观基因组数据注释和评估调控区域中的功能性变异 |
Ma, R. |
PDF |
N/A |
Annotation and assessment of functional variants in regulatory regions using epigenomic data in farm animals |
| 弯曲DNA会增加其螺旋重复 |
Chandrasekhar, S. |
PDF |
N/A |
Bending DNA increases its helical repeat |
| Hist2Cell：从组织学图像中解析细粒度的细胞结构 |
ZHAO, W. |
PDF |
N/A |
Hist2Cell: Deciphering Fine-grained Cellular Architectures from Histology Images |
| 一种混合效应相似性矩阵回归模型（SMRmix），用于在群落水平上整合多个微生物组数据集 |
He, M. |
PDF |
N/A |
A Mixed Effect Similarity Matrix Regression Model (SMRmix) for Integrating Multiple Microbiome Datasets at Community Level |
| 使用蛋白质三维二级结构预测转录因子 |
Liebold, J. |
PDF |
N/A |
Transcription factor prediction using protein 3Dsecondary structures |
| 次优的再喂养补偿了幼年营养不良小鼠模型中的生长迟缓 |
Thoumas, J.-L. |
PDF |
N/A |
Suboptimal refeeding compensates stunting in a mouse model of juvenile malnutrition |
| 睫状蛋白IFT88的时间性消融改变了正常的脑波模式 |
Strobel, M. R. |
PDF |
N/A |
Temporal Ablation of the Ciliary Protein IFT88 Alters Normal Brainwave Patterns |
| 评估在快速并行视觉呈现后形态-正字法、词汇和语法处理的时间进程：一项针对英语的脑电图研究。 |
Dunagan, D. |
PDF |
N/A |
Evaluating the timecourses of morpho-orthographic, lexical, and grammatical processing following rapid parallel visual presentation: an EEG investigation in English. |
| 肠道菌群失调不可避免，但耐受性并非如此：小鼠微生物群在维持其丁酸盐生产能力的时间反应与对慢性吗啡的持续抗痛觉相关。 |
Sall, I. J. |
PDF |
N/A |
Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine |
| Tol-Pal复合体在细菌外膜脂质稳态中的主要作用 |
Tan, W. B. |
PDF |
N/A |
Primary role of the Tol-Pal complex in bacterial outer membrane lipid homeostasis |
| 在高风险乳腺癌中，通过甘草查尔酮A重新编程SREBP1依赖的脂质生成和炎症：癌症预防的新途径 |
Hajirahimkhan, A. |
PDF |
N/A |
Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: a novel path to cancer prevention |
| 可溶性免疫介质协调了结核分枝杆菌复合群各系之间保护性的体外肉芽肿反应。 |
Arbues, A. |
PDF |
N/A |
Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages |
| 解决分布不匹配问题以实现有效的半监督神经元分割 |
Zhang, Y. |
PDF |
N/A |
Addressing Distribution Mismatch for Effective Semi-Supervised Neuron Segmentation |
| 神经影像去噪器，用于去除功能成像中瞬时荧光信号的噪声。 |
Weissbach, S. |
PDF |
N/A |
Neuroimage Denoiser for removing noise from transient fluorescent signals in functional imaging. |
| 无损时空分辨率的多光谱活细胞成像 |
Kumar, A. |
PDF |
N/A |
Multispectral live-cell imaging with uncompromised spatiotemporal resolution |
| 自适应渐渗分类方法的性能评估 |
Romieu, J. |
PDF |
N/A |
Performance evaluation of adaptive introgression classification methods |
| 同化型NADPH依赖性亚硫酸盐还原酶的二聚化揭示了在最小界面上结合双黄素还原酶的元素 |
Ghazi Esfahani, B. |
PDF |
N/A |
Dimerization of assimilatory NADPH-dependent sulfite reductase reveals elements for diflavin reductase binding at a minimal interface |
| 二聚化同化NADPH依赖性亚硫酸盐还原酶的结构揭示了双黄素还原酶结合的最小界面 |
Ghazi Esfahani, B. |
PDF |
N/A |
Structure of dimerized assimilatory NADPH-dependent sulfite reductase reveals the minimal interface for diflavin reductase binding |
| 发现猴痘病毒H3中的硫酸乙酰肝素结合域作为抗痘病毒药物靶点：结合AI与MD模拟 |
Zheng, B. |
PDF |
N/A |
Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combining AI and MD Simulations |
| 多样本非负空间分解 |
Wang, Y. |
PDF |
N/A |
Multi-sample non-negative spatial factorization |
| 早期繁殖选择导致果蝇种群加速衰老和广泛代谢重塑 |
Hubert, D. L. |
PDF |
N/A |
Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster populations |
| DNA序列的二维表示显示，大多数转换是与复制滑移相关的错配核苷酸。 |
Erives, A. J. |
PDF |
N/A |
2D representations of DNA sequence show that most transversions are misaligned nucleotides associated with replication slippage. |
| 婴儿脑电微状态动力学与在自然情境下与照顾者玩耍时婴儿注意力的细微模式相关 |
Bagdasarov, A. |
PDF |
N/A |
Infant EEG microstate dynamics relate to fine-grained patterns of infant attention during naturalistic play with caregivers |
| 全面化学分型和七种kisspeptin能神经元群体在小鼠大脑中的性腺调节 |
Hernandez, V. S. |
PDF |
N/A |
Comprehensive chemotyping, and the gonadal regulation, of seven kisspeptinergic neuronal populations in the mouse brain |
| 在形成、迁移和融合过程中，对三维肿瘤球体结构变化的非破坏性原位监测 |
Ning, K. |
PDF |
N/A |
Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process |
| 厌氧消化菌群中的代谢分离与功能基因簇 |
Wang, Y. |
PDF |
N/A |
Metabolic Segregation and Functional Gene Clusters in Anaerobic Digestion Consortia |
| 土壤微生物群落的持久性遗留效应有助于植物适应干旱反应 |
Ginnan, N. A. |
PDF |
N/A |
Persistent legacy effects on soil microbiota facilitate plant adaptive responses to drought |
| 揭示Galectin-1与脂质膜结合的GM1特异性 |
Scollo, F. |
PDF |
N/A |
Unraveling the GM1 specificity of Galectin-1 binding to lipid membranes |
| 在语言产生和理解过程中，前颞叶皮层中与语音学相关的特定一致性脑信号。 |
Dmitrieva, X. |
PDF |
N/A |
Congruent brain signatures specific to phonology in fronto-temporal cortex during language production and understanding. |
| Unipept在2024年：扩展的宏蛋白质组学分析，支持遗漏切割、半胰蛋白酶和非胰蛋白酶肽段 |
Vande Moortele, T. |
PDF |
N/A |
Unipept in 2024: Expanding metaproteomics analysis with support for missed cleavages, semi-tryptic and non-tryptic peptides |
| 在基于模拟的历史人口遗传数据推断中，更优的置信区间 |
Rousset, F. |
PDF |
N/A |
Better confidence intervals in simulation-based inference of historical demography from population genetic data |
| 近北极地区的蝙蝠（Myotis bats）广泛的长寿与DNA病毒驱动的适应性 |
Vazquez, J. M. |
PDF |
N/A |
Extensive longevity and DNA virus-driven adaptation in nearctic Myotis bats |
| 非协变存储效应：平衡和正向定向选择对突变等位基因的影响，这些等位基因放大了随机适应性和人口波动 |
Kim, Y. |
PDF |
N/A |
Noncovarying storage effect: balancing and positive directional selection on mutant alleles that amplify random fitness and demographic fluctuations |
| 稳定性与灵活性：在计算机中重塑古菌膜 |
Amaral, M. |
PDF |
N/A |
Stability vs flexibility: reshaping archaeal membranes in silico |
| 先天抗病毒系统是鲍曼不动杆菌中驱动前噬菌体分布的主要防御系统组成部分。 |
Moreno-Rodriguez, A. |
PDF |
N/A |
Innate antiviral systems are major defensome components that drive prophage distribution in Acinetobacter baumannii |
| PSTP：通过迁移学习和注意力机制解码蛋白质相分离的潜在序列语法 |
Feng, M. |
PDF |
N/A |
PSTP: Decoding Latent Sequence Grammar for Protein Phase Separation through Transfer Learning and Attention |
| 一种定义细胞类型特异性CTCF结合和染色质组织的基因组范围代码 |
Do, C. |
PDF |
N/A |
A genome wide code to define cell-type specific CTCF binding and chromatin organization |
| 肿瘤缺氧细胞外囊泡为三阴性乳腺癌创造了一个保护性微环境 |
Pachane, B. C. |
PDF |
N/A |
Tumoral hypoxic extracellular vesicles create a protective microenvironment for triple-negative breast cancer |
| 全息显微镜揭示了在血管内皮化过程中，无需标记的内皮细胞定量动态变化。 |
Leineweber, W. D. |
PDF |
N/A |
Holotomographic microscopy reveals label-free quantitative dynamics of endothelial cells during endothelialization |
| PLM-interact：扩展蛋白质语言模型以预测蛋白质-蛋白质相互作用 |
Liu, D. |
PDF |
N/A |
PLM-interact: extending protein language models to predict protein-protein interactions |
| 线粒体的不均等分配在神经发生过程中促进不对称命运 |
Bunel, B. |
PDF |
N/A |
Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis |
| 晚更新世巴西东南部灰侏儒鹿摄食策略的千年尺度稳定性。 |
Hubbe, A. |
PDF |
N/A |
Late Quaternary millennial-scale stability of the feeding strategy of the gray brocket deer in Southeastern Brazil. |
| 稀疏矩阵分解能够稳健地处理全基因组关联研究（GWAS）中样本共享的问题，从而揭示出可解释的遗传成分。 |
Omdahl, A. R. |
PDF |
N/A |
Sparse matrix factorization robust to sample sharing across GWAS reveals interpretable genetic components |
| 发育阶段和细胞环境决定Ezh2Y641F突变在造血中的致癌和分子结果 |
Zimmerman, S. M. |
PDF |
N/A |
Developmental Stage and Cellular Context Determine Oncogenic and Molecular Outcomes of Ezh2Y641F Mutation in Hematopoiesis |
| AlphaFold 对全基因组的预测概览 |
Cazals, F. |
PDF |
N/A |
AlphaFold predictions on whole genomes at a glance |
| 通过原位多聚腺苷酸化和空间RNA测序实现微生物群-宿主相互作用的高分辨率空间映射 |
Ntekas, I. |
PDF |
N/A |
High Resolution Spatial Mapping of Microbiome-Host Interactions via in situ Polyadenylation and Spatial RNA Sequencing |
| 大肠杆菌细胞宽度稳态和膨胀动力学的力学机制：MreB和隔膜抑制的影响 |
Kale, T. |
PDF |
N/A |
Mechanics of E. coli cell width homeostasis and bulging dynamics from MreB and septum inhibition |
| 通过化学物质灌注去除兔心脏中的DNA含量，同时保持胶原蛋白和糖胺聚糖不变。 |
Seitzhaparova, B. |
PDF |
N/A |
Perfusion via chemicals removes the DNA content of rabbit hearts while keeping the collagen and glycosaminoglycan unaltered |
| 结核分枝杆菌中一种新型放线菌特异性核糖体休眠因子 |
Majumdar, S. |
PDF |
N/A |
A Novel Actinobacteria-Specific Ribosome Hibernation Factor in Mycobacterium tuberculosis |
| 汉密尔顿法则的一般版本 |
van Veelen, M. |
PDF |
N/A |
The general version of Hamilton's rule |
| 在人类细胞中表达重组人谷氨酰化TTLLs会导致不同的微管谷氨酰化模式，只有TTLL6会破坏微管动力学。 |
Al Kabbani, M. A. |
PDF |
N/A |
Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics |
| 量子自旋共振在工程化磁敏荧光蛋白中的应用，使得活细胞内的多模态传感成为可能 |
Abrahams, G. J. |
PDF |
N/A |
Quantum Spin Resonance in Engineered Magneto-Sensitive Fluorescent Proteins Enables Multi-Modal Sensing in Living Cells |
| 多个冗余的羧酸转运蛋白支持恶性疟原虫的线粒体代谢 |
Rajaram, K. |
PDF |
N/A |
MULTIPLE, REDUNDANT CARBOXYLIC ACID TRANSPORTERS SUPPORT MITOCHONDRIAL METABOLISM IN PLASMODIUM FALCIPARUM |
| 细菌RNA中假尿苷的定量图谱 |
Sharma, S. |
PDF |
N/A |
Quantitative mapping of pseudouridines in bacteria RNA |
| PyRID：一个用Python编写的反应性粒子和相互作用粒子的布朗动力学模拟器 |
Becker, M. |
PDF |
N/A |
PyRID: A Brownian dynamics simulator for reacting and interacting particles written in Python |
| NaviNIBS：一个全面且开源的软件工具箱，用于神经导航的无创脑刺激。 |
Cline, C. C. |
PDF |
N/A |
NaviNIBS: a comprehensive and open-source software toolbox for neuronavigated noninvasive brain stimulation. |
| 剥脱性青光眼中的线粒体和微管缺陷 |
Venkatesan, A. |
PDF |
N/A |
Mitochondrial and Microtubule Defects in Exfoliation Glaucoma |
| 血小板因子4（PF4）调节造血干细胞衰老 |
Zhang, S. |
PDF |
N/A |
Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging |
| 利用杆状病毒载体成功递送CRISPR-Cas9至昆虫脑部目标 |
Dogan, B. E. K. |
PDF |
N/A |
Successful delivery of CRISPR-Cas9 with a baculovirus vector for insect brain targets |
| TimeFlies：一种用于果蝇头部衰老时钟的snRNA-seq技术揭示了性别偏向的衰老现象 |
Tennant, N. |
PDF |
N/A |
TimeFlies: an snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging |
| 经过工程改造的CRISPR-碱基编辑器：家族性自主神经功能异常的永久性治疗方法 |
Yun, S. |
PDF |
N/A |
Engineered CRISPR-Base Editors as a Permanent Treatment for Familial Dysautonomia |
| 跑步机速度在步态周期内变化引起的四肢协调变化 |
Hall, B. L. |
PDF |
N/A |
Changes in interlimb coordination induced by within-stride changes in treadmill speed |
| 天生相连：婴儿是否已经具备与成人相似的多尺度连接网络？ |
Bajracharya, P. |
PDF |
N/A |
Born Connected: Do Infants Already Have Adult-Like Multi-Scale Connectivity Networks? |
| 快速语义处理：一项关于叙事文本阅读的MEG研究 |
Neklyudova, A. |
PDF |
N/A |
Rapid Semantic Processing: An MEG Study of Narrative Text Reading |
| 感觉运动同步经颅磁刺激（seTMS）能够增强运动皮层的兴奋性。 |
Ross, J. M. |
PDF |
N/A |
Sensory Entrained TMS (seTMS) enhances motor cortex excitability |
| 瞳孔大小变化揭示了认知算术中的贝叶斯推理 |
Zenon, A. |
PDF |
N/A |
Pupil size variations reveal Bayesian inference in cognitive arithmetic |
| Rac1抑制可预防转甲状腺素蛋白淀粉样变多发性神经病变中的轴突细胞骨架功能障碍 |
Magalhaes, J. |
PDF |
N/A |
Rac1 inhibition prevents axonal cytoskeleton dysfunction in Transthyretin Amyloid Polyneuropathy |
| 个体差异在音乐熟悉度和音乐特征对放松时大脑活动的影响中的作用 |
Scarratt, R. J. |
PDF |
N/A |
Individual differences in the effects of musical familiarity and musical features on brain activity during relaxation |
| 化学标记法：一种通过体内钙成像识别细胞类型的化学遗传学方法 |
Ko, B. |
PDF |
N/A |
Chemotagging: a chemogenetic approach for identifying cell types with in vivo calcium imaging |
| 不同他汀类药物对亚麻醉氯胺酮抗运动障碍活性的影响存在差异 |
Bartlett, M. J. |
PDF |
N/A |
Differential effects of statins on the anti-dyskinetic activity of sub-anesthetic ketamine |
| 通过长程连接在皮层区域之间建立动态共识 |
Javadzadeh, M. |
PDF |
N/A |
Dynamic consensus-building between neocortical areas via long-range connections |
| 利用功能性超声成像技术探索乌鸦听觉端脑中的神经动力学 |
Liao, D. A. |
PDF |
N/A |
Exploring Neural Dynamics in the Auditory Telencephalon of Crows using Functional Ultrasound Imaging |
| 白质高信号和小型塑料颗粒 |
Bearer, E. L. |
PDF |
N/A |
White matter hyperintensities and microplastics |
| 白质微观结构与青少年、中年和晚年的大脑、身体和遗传特征相关联。 |
Korbmacher, M. |
PDF |
N/A |
White matter microstructure links with brain, bodily and genetic attributes in adolescence, mid- and late life |
| 一个人类化的神经元模型系统揭示了锰在神经元内吞作用、钙离子通量和线粒体生物能量学中的关键作用 |
Budinger, D. |
PDF |
N/A |
A humanized neuronal model system reveals key roles for manganese in neuronal endocytosis, calcium flux and mitochondrial bioenergetics |
| 个体化神经生理特征的寿命演变 |
da Silva Castanheira, J. |
PDF |
N/A |
The Lifespan Evolution of Individualized Neurophysiological Traits |
| 胰岛素抵抗、认知功能与肥胖老年人的功能性脑网络拓扑结构 |
McIntyre, C. C. |
PDF |
N/A |
Insulin resistance, cognition, and functional brain network topology in older adults with obesity |
| 鉴定出一种源自SARS-CoV2 S1蛋白的肽段，该肽段具有类似超抗原的T细胞刺激特性。 |
Tu, T. H. |
PDF |
N/A |
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells |
| 不同微气候下土壤微生物群落的比较分析 |
Pall, T. |
PDF |
N/A |
Comparative analysis of microbial communities of soils under contrasting microclimates |
| 在妊娠早期乳腺腺泡增殖和分化的转录调控 |
Garcia-Lerena, J. |
PDF |
N/A |
Transcriptional Regulation of Mammary Alveolar Proliferation and Differentiation during Early Pregnancy |
| 小鼠十二指肠在全身致死剂量辐射后恢复期间的转录组 |
He, L. |
PDF |
N/A |
Transcriptome of the murine duodenum during recovery after a lethal dose of total body irradiation |
| 一个特定谱系驱动因子库将果蝇腹神经索中发育中的神经回路与行为联系起来。 |
Soffers, J. H. |
PDF |
N/A |
A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord. |
| 通过光调控激酶对内源标记蛋白进行体内调控 |
vigano, a. m. |
PDF |
N/A |
In vivo regulation of an endogenously-tagged protein by a light-regulated kinase |
| 一种在头部固定小鼠中探索虚拟现实的环境性恐惧条件化范式。 |
Krishnan, S. |
PDF |
N/A |
A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality. |
| 分枝杆菌蛋氨酸氨肽酶1c型在30S核糖体亚基上兼职作为抗关联因子 |
Banerjee, A. |
PDF |
N/A |
Mycobacterial methionine aminopeptidase type 1c moonlights as an anti-association factor on the 30S ribosomal subunit |
| 通过冷冻电镜结合构建和检索方法，阐明天然血小板膜中整合素αIIb3的动力学 |
Han, X. |
PDF |
N/A |
Elucidating the dynamics of Integrin αIIb3 from native platelet membranes by cryo-EM with build and retrieve method |
| 重新布线大肠杆菌以将甲酸盐转化为甲基基团 |
Mohr, M. K. F. |
PDF |
N/A |
Rewiring Escherichia coli to Transform Formate into Methyl Groups |
| 成功建立了基于病毒复制元件的莱茵衣藻叶绿体外源基因表达系统 |
Jiang, Y. |
PDF |
N/A |
Successful establishment of an exogenous gene expression system in Chlamydomnas chloroplast based on viral replication elements |
| 优化的大肠杆菌亮氨酰-tRNA合成酶定向进化能够将许多非标准氨基酸加入真核生物遗传密码中，包括鸟氨酸和Nε-乙酰甲基赖氨酸。 |
Ficaretta, E. D. |
PDF |
N/A |
Optimized directed evolution of E. coli leucyl-tRNA synthetase adds many noncanonical amino acids into the eukaryotic genetic code including ornithine and Nepsilon-acetyl-methyllysine |
| 在缺氧-缺血性脑病体外模型中，物理调控的间充质干细胞分泌组具有更高的能力来保护神经网络和翻译过程。 |
Caramelo, I. |
PDF |
N/A |
Physioxia-modulated mesenchymal stem cells secretome has higher capacity to preserve neuronal network and translation processes in hypoxic-ischemic encephalopathy in vitro model |
| UniSPAC：一种用于连接组学中校对和注释的统一分割框架 |
Deng, J. |
PDF |
N/A |
UniSPAC: A Unified Segmentation Framework for Proofreading and Annotation in Connectomics |
| 系统性暴露于新冠病毒样颗粒会调节活体小鼠大脑皮层神经元的放电模式。 |
Das, A. |
PDF |
N/A |
Systemic exposure to COVID-19 virus-like particles modulates firing patterns of cortical neurons in the living mouse brain |
| 视觉-前庭整合与自我运动：人类皮层区域V6偏好向前和对齐的刺激 |
Marchand, S. |
PDF |
N/A |
Visuo-Vestibular Integration for Self-Motion: Human Cortical Area V6 Prefers Forward and Congruent Stimuli |
| 青春期激素与青春期早期女性大脑：一项多模态脑部MRI研究 |
Khetan, M. |
PDF |
N/A |
Pubertal hormones and the early adolescent female brain: a multimodality brain MRI study |
| 纤毛病与新生儿麻醉相互作用，导致非凋亡性胱天冬酶介导的运动功能障碍 |
Saric, N. |
PDF |
N/A |
Ciliopathy interacts with neonatal anesthesia to cause non-apoptotic caspase-mediated motor deficits |
| 一种可编程的、无需选择的金黄色葡萄球菌CRISPR干扰系统 |
Miah, R. |
PDF |
N/A |
A programmable, selection-free CRISPR interference system in Staphylococcus aureus |
| 鉴定并基因表征了一种新型双节冠状病毒在小熊猫中的存在 |
chen, x. |
PDF |
N/A |
Identification and genomic characterization of a novel bisegmented coronavirus in the lesser panda |
| 对一个由宏基因组组装而成的基因组进行比较基因组分析，揭示了Mucoromycotina细根内生菌丛枝菌根真菌中独特的共生特征。 |
Cole, J. |
PDF |
N/A |
Comparative genomic analysis of a metagenome-assembled genome reveals distinctive symbiotic traits in a Mucoromycotina fine root endophyte arbuscular mycorrhizal fungus |
| 未被探索的种子微生物群中的酵母多样性 |
Marchi, M. |
PDF |
N/A |
Unexplored Yeast diversity in Seed Microbiota |
| 碳青霉烯类耐药高毒力肺炎克雷伯菌的分子流行病学：中国地区头孢他啶/阿维巴坦耐药的风险因素及耐药机制 |
Wang, N. |
PDF |
N/A |
Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae: Risk factors and resistance mechanism of ceftazidime/avibactam in China |
| 幽门螺杆菌孤儿ATTAAT特异性甲基转移酶M.Hpy99XIX在铁代谢相关基因的协调调控中起着核心作用。 |
Gottschall, W. |
PDF |
N/A |
The Helicobacter pylori orphan ATTAAT-specific methyltransferase M.Hpy99XIX plays a central role in the coordinated regulation of genes involved in iron metabolism |
| 弓形虫的代谢适应性与营养摄取：从摄入途径缺陷型突变体中获得的启示 |
Rimple, P. A. |
PDF |
N/A |
Metabolic Adaptability and Nutrient Scavenging in Toxoplasma gondii: Insights from Ingestion Pathway-Deficient Mutants |
| 采用新型多重qPCR技术，在唾液中鉴定出大量aliC和aliD基因，以提高特异性，对II组非荚膜肺炎球菌进行表征。 |
Laxton, C. S. |
PDF |
N/A |
An abundance of aliC and aliD genes were identified in saliva using a novel multiplex qPCR to characterize group II non-encapsulated pneumococci with improved specificity |
| 基于人群的元蛋白质组学揭示了肠道微生物群与表型之间的功能关联 |
Liang, S. |
PDF |
N/A |
Population-based metaproteomics reveals functional associations between gut microbiota and phenotypes |
| 广泛存在的一类孔形成效应器扩大了沙雷氏菌VI型分泌系统的影响 |
Reglinski, M. |
PDF |
N/A |
A widely-occurring family of pore-forming effectors broadens the impact of the Serratia Type VI secretion system |
| 2022年来自谱系2.3.4.4b的禽流感H5N1病毒比2005年来自谱系2.3.2.1的H5N1病毒在人类呼吸道上皮细胞中更好地附着和复制。 |
Bauer, L. |
PDF |
N/A |
A 2022 avian H5N1 influenza A virus from clade 2.3.4.4b attaches to and replicates better in human respiratory epithelium than a 2005 H5N1 virus from clade 2.3.2.1 |
| 炎性间质基质细胞和IFN反应性T细胞是CHIP和MDS中人类骨髓微环境重塑的关键介质。 |
Prummel, K. D. |
PDF |
N/A |
Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDS |
| 通过瞬时递送CRISPR表观基因组编辑器核糖核蛋白实现可编程的表观基因组编辑 |
Nunez, J. K. |
PDF |
N/A |
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins |
| 使用多重Cas12a sgRNA实现体内基因敲除并消除脱靶效应 |
Port, F. |
PDF |
N/A |
Enhanced in vivo gene knockout with undetectable off-targets using multiplexed Cas12a sgRNAs |
| 配对CRISPR筛选以绘制顺式和反式基因调控 |
Xue, X. |
PDF |
N/A |
Paired CRISPR screens to map gene regulation in cis and trans |
| 氨基酸酰-RNA环闭合连接的立体选择性 |
Kim, S. |
PDF |
N/A |
Stereoselectivity of Aminoacyl-RNA Loop-closing Ligation |
| 通过促炎性S100A9和与神经退行性疾病相关的α-突触核蛋白形成异型液滴 |
Veiveris, D. |
PDF |
N/A |
Heterotypic droplet formation by pro-inflammatory S100A9 and neurodegenerative disease-related alpha-synuclein |
| 广泛存在的肠杆菌过氧化物酶包封体的结构和生化特性 |
Ubilla-Rodriguez, N. C. |
PDF |
N/A |
Structural and biochemical characterization of a widespread enterobacterial peroxidase encapsulin |
| 肽类凝聚体递送以在细胞内形成稳定的相互作用枢纽 |
Tu, W. |
PDF |
N/A |
Delivery of Peptide Coacervates to Form Stable Interaction Hubs In Cells |
| 使用3T fMRI区分脑干中相邻体感核团的活动 |
Howell, P. |
PDF |
N/A |
Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI |
| 紊乱的海马再激活可预测阿尔茨海默病小鼠模型中的空间记忆缺陷 |
Shipley, S. |
PDF |
N/A |
Disordered Hippocampal Reactivations Predict Spatial Memory Deficits in a Mouse Model of Alzheimer's Disease |
| 一种用于抗生素优化的生成式人工智能方法 |
Torres, M. D. T. |
PDF |
N/A |
A generative artificial intelligence approach for antibiotic optimization |
| PACT与ADAR1在防止自源双链RNA异常激活PKR中的协同作用 |
Manjunath, L. |
PDF |
N/A |
Cooperative Role of PACT and ADAR1 in Preventing Aberrant PKR Activation by Self-Derived Double-Stranded RNA |
| 色氨酸饥饿对包涵体膜组成及衣原体-宿主相互作用的影响 |
Riffaud-Widner, C. M. |
PDF |
N/A |
Effect of tryptophan starvation on inclusion membrane composition and chlamydial-host interactions |