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BioRxiv 2024-11-29 Papers

标题 作者 PDF链接 代码仓库 Title
撤回:利用物理信息元神经表示实现生物动力学的高保真、可泛化光场重构 Yi, C. PDF N/A WITHDRAWN: High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation
芯片感染:一种用于研究脑膜炎奈瑟菌定植和血管损伤的体外人血管模型 Pinon, L. PDF N/A Infection-on-Chip: an in vitro human vessel to study Neisseria meningitidis colonization and vascular damages
mbctools: 一个用户友好的宏条形码分析和跨平台管道,用于分析大量生物多样性中的多种扩增子测序数据 Barnabe, C. PDF N/A mbctools: A User-Friendly Metabarcoding and Cross-Platform Pipeline for Analyzing Multiple Amplicon Sequencing Data across a Large Diversity of Organisms
挑战反向传播:皮质中目标学习的证据 Aceituno, P. V. PDF N/A Challenging Backpropagation: Evidence for Target Learning in the Cortex
急性心理社会压力诱导的能量应激标志物GDF15 Huang, Q. PDF N/A The Energetic Stress Marker GDF15 is Induced by Acute Psychosocial Stress
灵活的海马体对抽象边界的表征支持记忆引导的选择。 Esposito, M. PDF N/A Flexible hippocampal representation of abstract boundaries supports memory-guided choice.
一项系统综述量化了负责病原体传播的库蠓属物种的宿主吸食模式 Fairbanks, E. L. PDF N/A A systematic review quantifying host feeding patterns of Culicoides species responsible for pathogen transmission
子宫肌瘤和宫颈癌中DEK表达的上调作为潜在的预后因素 Janiak, A. PDF N/A Upregulation of DEK Expression in Uterine Myomas and Cervical Cancer as a Potential Prognostic Factor
探索SNP过滤策略:严格核心与软核心的影响 Taouk, M. L. PDF N/A Exploring SNP Filtering Strategies: The Influence of Strict vs Soft Core
多聚磷酸盐比DNA更有效地区分蛋白质构象系综,促进多样化的组装和成熟行为。 Goyal, S. PDF N/A Polyphosphate Discriminates Protein Conformational Ensembles More Efficiently than DNA Promoting Diverse Assembly and Maturation Behaviors
撤回:miRBench:一个全面的微RNA结合位点预测训练和基准测试数据集 Sammut, S. PDF N/A WITHDRAWN: miRBench: A Comprehensive microRNA Binding Site Prediction Training and Benchmarking Dataset
人工智能建模能否区分传感器和辅助NLR免疫受体之间的蛋白质结构差异? Toghani, A. PDF N/A Can AI modelling of protein structures distinguish between sensor and helper NLR immune receptors?
从辣木(Moringa oleifera)种子中提取的纯化几丁质结合蛋白对小鼠伊立替康诱导的肠道黏膜炎的治疗效果 Ferreira, K. Q. PDF N/A Therapeutic effects of a purified chitin-binding protein from Moringa oleifera seeds on irinotecan-induced intestinal mucositis in mice
帕金森病影响快速视觉运动反应的上下文控制,但不影响其表达,该反应启动视觉引导的伸手动作:多重交互运动通路的证据及其对帕金森病运动症状的启示 Gilchrist, M. PDF N/A Parkinson's Disease affects the contextual control, but not the expression, of a rapid visuomotor response that initiates visually-guided reaching: Evidence for multiple, interacting motor pathways and implications for motor symptoms in Parkinson's Disease
静息状态下的阿尔法反应性在帕金森病中降低,并与步态变异性相关。 Lirani-Silva, E. PDF N/A Resting-state alpha reactivity is reduced in Parkinson disease and associated with gait variability
在自然音乐聆听过程中人类听觉皮层的多流预测 Robert, P. PDF N/A Multi-stream predictions in human auditory cortex during natural music listening
利用深度学习从大脑结构预测内化问题 Vandewouw, M. M. PDF N/A Using deep learning to predict internalizing problems from brain structure
失眠症患者静息态功能磁共振成像研究揭示脑动力学模型显示脑状态切换减少 Jespersen, K. V. PDF N/A Modelling of brain dynamics reveals reduced switching between brain states in insomnia disorder - a resting state fMRI study
未知来源的自发性炎症的成年患者在免疫表现上部分类似于斯蒂尔病。 Veiga, R. PDF N/A Adults patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still's disease
对伊拉克患者中鲍氏不动杆菌和索布雷菌医院感染的碳青霉烯酶编码基因的调查 Al-Ouqaili, M. T. S. PDF N/A An investigation of carbapenemase-encoding genes in Burkholderia cepacia and Aeromonas sobria nosocomial infections among Iraqi patients
拮抗细菌对不同军团菌种的抑制作用存在差异 Cavallaro, A. PDF N/A Variable inhibition of different Legionella species by antagonistic bacteria
大型建筑物饮用水系统中军团菌肺炎菌株的基因组分析,历时25年 Seth-Smith, H. M. PDF N/A Genomic Analysis of Legionella pneumophila in the Drinking Water System of a Large Building over 25 Years
MuMu:一种用于基于液滴的同时单细胞核RNA测序和ATAC测序系统的样本多路复用协议 Li, Z. PDF N/A MuMu: a sample multiplexing protocol for droplet-based simultaneous single nuclei RNA- and ATAC-seq systems
在预先使用硫芥子素结合物处理的树突状细胞中抑制NF-kappaB可诱导免疫耐受 Palomares, F. PDF N/A NF-kappaB inhibition in dendritic cells pre-treated with sulforaphane-conjugates induces immunotolerance
针对白纹伊蚊的不相容昆虫技术的发展:引入野生核背景恢复了人工感染沃尔巴克氏菌雄蚊的表现 Lejarre, Q. PDF N/A Development of the Incompatible Insect Technique targeting Aedes albopictus: introgression of a wild nuclear background restores the performance of males artificially infected with Wolbachia
液泡pH通过TORC1信号传导在酵母复制衰老过程中调节网格蛋白介导的内吞作用 Antenor, K. G. PDF N/A Vacuolar pH regulates clathrin-mediated endocytosis through TORC1 signaling during yeast replicative aging
成熟的簇细胞表型沿着肠道隐窝-绒毛轴在细胞因子诱导的簇细胞增生后依次表达。 des Amorie, J. R. B. PDF N/A Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia
突触线粒体的生物能量特征 Faria-Pereira, A. PDF N/A Bioenergetic signature of Synaptic mitochondria
GABRA1移码变异损害GABAA受体蛋白稳态 Williams, M. P. PDF N/A GABRA1 frameshift variants impair GABAA receptor proteostasis
动脉粥样易损血流激活SMAD-FOXO1驱动内皮间质转化及动脉粥样硬化 Knaus, P. PDF N/A Atheroprone Flow Activates SMAD-FOXO1 to drive Endothelial-to-Mesenchymal Transition and Atherosclerosis
TFEB/HLH-30介导的成年早期神经元溶酶体容量扩展在衰老过程中保护秀丽隐杆线虫树突的维持 Zhong, R. PDF N/A TFEB/HLH-30-mediated expansion of neuronal lysosomal capacity in early adulthood protects dendrite maintenance during aging in Caenorhabditis elegans
仿生多孔硅用于合理设计的联合疗法,以诱导免疫原性细胞死亡 Saarela, S. PDF N/A Biomimetic porous silicon for rationally engineered combination therapy to induce immunogenic cell death
用于空间飞行基因表达谱分析的Perturb-Seq数据机器学习模型 Johnson, L. F. PDF N/A A Machine Learning Model of Perturb-Seq Data for Use in Space Flight Gene Expression Profile Analysis
从综合AI和聚合物物理模型中得出的染色质结构 Schultz, E. R. PDF N/A Chromatin Structures from Integrated AI and Polymer Physics Model
电荷筛选和疏水性驱动反射蛋白的逐步组装和液-液相分离 Gordon, R. PDF N/A Charge screening and hydrophobicity drive progressive assembly and liquid-liquid phase separation of reflectin protein
含有糖脂的多分散寡层囊泡的小角和准弹性中子散射 Bange, L. PDF N/A Small-angle and quasi-elastic neutron scattering from polydisperse oligolamellar vesicles containing glycolipids
智能三维超分辨率显微镜揭示了核仁中RNA支架的结构 Berrevoets, E. S. PDF N/A Smart 3D super-resolution microscopy reveals the architecture of the RNA scaffold in a nuclear body
脂质纳米颗粒pH驱动相变的机理洞察 Trollmann, M. F. PDF N/A Mechanistic Insight into pH-Driven Phase Transition of Lipid Nanoparticles
利用傅里叶叠层散射光显微技术解析脑、关节和肌肉组织的结构复杂性 van Staalduine, S. E. PDF N/A Deciphering Structural Complexity of Brain, Joint, and Muscle Tissues Using Fourier Ptychographic Scattered Light Microscopy
遗传性痉挛性截瘫相关突变残基的结构和功能作用:从katanin螺旋到环状结构转变模拟中获得的见解 Kelly, M. S. PDF N/A Structural and functional role of residues undergoing hereditary spastic paraplegias-linked mutations: insights from a simulation of the spiral to ring transition in katanin
对细菌外膜脂质稳态中重要的马达-定子复合物力传导机制的结构洞察 Yeow, J. PDF N/A Structural insights into the force-transducing mechanism of a motor-stator complex important for bacterial outer membrane lipid homeostasis
解密Cav1中的Ca²⁺渗透与价态选择性:分子动力学模拟揭示三离子撞击机制 Xue, L. PDF N/A Deciphering Ca2+ Permeation and Valence Selectivity in Cav1: Molecular Dynamics Simulations Reveal the Three-Ion Knock-on Mechanism
对动力蛋白-动力蛋白激活蛋白-NuMA复合物的激活和调控的结构和功能见解 Aslan, M. PDF N/A Structural and functional insights into activation and regulation of the dynein-dynactin-NuMA complex
具有内在无序区域的转录因子设计原则 Ji, W. PDF N/A Design principles of transcription factors with intrinsically disordered regions
多组学分析揭示了溶瘤性寨卡病毒感染儿童脑肿瘤细胞所引发的关键免疫原性特征 Sherwood, M. PDF N/A Multiomics analysis reveals key immunogenic signatures induced by oncolytic Zika virus infection of paediatric brain tumour cells
空间通量平衡分析揭示了肾癌和结直肠癌的组织来源和空间依赖性代谢重编程 Maspero, D. PDF N/A Spatial Flux Balance Analysis reveals tissue-of-origin and spatially dependent metabolic rewiring in renal and colorectal cancer
来自EIAV疫苗的环境因素通过减弱NLRP3与NEK7的相互作用,精细调控NLRP3的激活。 Guo, x. PDF N/A Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction
在恒河猴中针对HIV包膜糖蛋白的保守融合肽进行免疫聚焦 Pratap, P. P. PDF N/A Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques
城市化与当地环境异质性对热带蛙类表型变异性的影响 Provete, D. B. PDF N/A The effect of urbanization and local environmental heterogeneity on phenotypic variability in a tropical frog
全球的山路显著改变了当地土壤的微气候。 Lejeune, R. PDF N/A Mountain roads across the globe significantly alter local soil microclimates
基因网络拓扑结构驱动基因表达的突变景观 Le Rouzic, A. PDF N/A Gene network topology drives the mutational landscape of gene expression
人类转录因子在跨组织中的异构体转换提示了一种广泛存在的调控机制。 Sidorov, S. PDF N/A Cross-tissue isoform switches by human transcription factors suggest a widespread regulatory mechanism
新型沙雷氏菌(Serratia sarumanii)菌株GBS19的农药降解能力及其基因组特征 Alatassi, G. PDF N/A Pesticide degradation capacity of a novel strain belonging to Serratia sarumanii (GBS19) with its genomic profile
利用纳米孔的马达蛋白辅助糖链转移和测序 Gao, Z. PDF N/A Motor protein-assisted glycan translocation and sequencing using nanopores
鉴定神经调节蛋白为SERCA2b调节蛋白样蛋白及其通过粗粒度模拟评估其聚集倾向。 Ben Mariem, O. PDF N/A Identification of neuronatin as a SERCA2b regulin-like protein and assessment of its aggregation propensity via coarse grained simulations.
解码糖基转移酶-B酶中决定底物特异性的因素——来自机器学习模型的见解 Hennen, S. PDF N/A Decoding substrate specificity determining factors in glycosyltransferase-B enzymes - Insights from machine learning models
利用系统免疫学方法连接免疫型和肠型 Affaticati, F. PDF N/A Bridging immunotypes and enterotypes using a systems immunology approach
肠道微生物群中细菌丰度的时间波动生态尺度取决于个体微生物物种和细菌群落的功能特性 Su, P. PDF N/A Ecological Scaling of Temporal Fluctuations with Bacterial Abundance in Gut Microbiota Depends on Functional Properties of Individual Microbial Species and Bacterial Communities
对八种人类呼吸道病毒的污水监测:浓度法与直接提取法的基准测试及其对新型病原体快速应用的启示 Jiang, M. PDF N/A Benchmarking concentration and direct extraction methods for wastewater-based surveillance of eight human respiratory viruses: implications for rapid application to novel pathogens
血浆蛋白酶-哌喹悖论持续存在 Walsh, B. PDF N/A The Plasmepsin-Piperaquine Paradox Persists
在热应激期间小鼠胚胎干细胞中RNA聚合酶III转录的动态调节 Nguyen, T. F. PDF N/A Dynamic regulation of RNA Polymerase III transcription in mouse embryonic stem cells during heat shock stress
AEGIS:基于个体的生命史进化模型 Bagic, M. PDF N/A AEGIS: individual-based modeling of life history evolution
通过自然转化在人类肠道微生物组中测量微生物群落范围内的抗生素抗性传播 Chowdhury, N. N. PDF N/A Measuring Microbial Community-Wide Antibiotic Resistance Propagation via Natural Transformation in the Human Gut Microbiome
使用对称多项逻辑回归增强单核苷酸多态性基因分型 Nielsen, M. B. PDF N/A Enhanced SNP Genotyping with Symmetric Multinomial Logistic Regression
使用DNBSEQ全基因组测序进行结构变异检测的性能评估 Rao, J. PDF N/A Performance evaluation of structural variation detection using DNBSEQ whole-genome sequencing
对Lasius蚁属的基因组数据进行去污染,以实现准确的物种划分和杂交检测 Jecha, K. PDF N/A Decontaminating genomic data for accurate species delineation and hybrid detection in the Lasius ant genus
来自Thermococcus onnurineus的热稳定CAS-Cas4对分支DNA的处理:扩展核酸酶活性的生化景观 Jain, M. PDF N/A Branched DNA Processing by a Thermostable CAS-Cas4 from Thermococcus onnurineus: Expanding Biochemical Landscape of Nuclease Activity
基于mTurquoise2的葡萄糖生物传感器 Botman, D. PDF N/A An mTurquoise2-based glucose biosensor
通过超解旋酶介导的等温扩增,实现了对高度重复或低复杂度序列DNA的可靠扩增。 Kang, J. PDF N/A Reliable amplification of highly repetitive or low complexity sequence DNA enabled by superhelicase-mediated isothermal amplification
从头功能发现来自重组酶构建的大多样性单克隆T细胞库中的肽-MHC限制性CARs Wang, Z. PDF N/A De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries
用于RNA功能和结构预测的大规模基础模型 Zou, S. PDF N/A A Large-Scale Foundation Model for RNA Function and Structure Prediction
嵌入式极值搜索:一种生物合成优化器 Smart, B. C. PDF N/A Embedded Extremum Seeking: A Bio-synthetic Optimiser
利用自适应反馈控制工程细胞命运 Britto Bisso, F. PDF N/A Engineering cell fate with adaptive feedback control
在CD4结合位点映射关键体细胞超突变有助于HIV-1疫苗设计 Dam, K.-M. A. PDF N/A Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design
Raver1将Ripk1 RNA剪接与caspase-8介导的焦亡细胞死亡、炎症及病原体抵抗联系起来 Zhang, B. PDF N/A Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance
抗体反应的亲和力成熟是由不同浆细胞增殖介导的。 MacLean, A. J. PDF N/A Affinity maturation of antibody responses is mediated by differential plasma cell proliferation
从表型到受体:通过全面的受体分析验证大肠杆菌噬菌体的生理聚类 Kaneko, T. PDF N/A From phenotype to receptor: validating physiological clustering of Escherichia coli phages through comprehensive receptor analysis
鉴定临床碳青霉烯酶、478种新型β-内酰胺酶以及从受污染的高北极峡湾沉积物中推测出的七个新的细菌门类。 Marathe, N. P. PDF N/A Identification of clinical carbapenemases, 478 novel β-lactamases and putative seven new bacterial phyla from wastewater contaminated high arctic fjord sediments.
利用DeepCellMap这一结合深度学习和空间统计的深度学习方法,解析发育中人脑中微胶质细胞的空间组织结构。 Perochon, T. PDF N/A Unraveling Microglial Spatial Organization in the Developing Human Brain with DeepCellMap, a Deep Learning Approach Coupled to Spatial Statistics
单细胞RNA测序显示,三刺鱼中没有减数分裂性染色体失活的现象。 Shaw, D. PDF N/A Single cell RNA-sequencing reveals no evidence for meiotic sex chromosome inactivation in the threespine stickleback fish
一种药物分子伴侣稳定剂能够挽救G蛋白偶联受体中绝大多数致病变异体的表达。 Mighell, T. PDF N/A A pharmacological chaperone stabilizer rescues the expression of the vast majority of pathogenic variants in a G protein-coupled receptor
增强多基因适应性检测:基于模拟进化与重测序数据的机器学习与统计方法比较研究 Caliendo, C. PDF N/A Enhancing Detection of Polygenic Adaptation: A Comparative Study of Machine Learning and Statistical Approaches Using Simulated Evolve-and-Resequence Data
寄生蜂Nasonia vitripennis的发育性DNA甲基化 Thomas, C. L. PDF N/A Developmental DNA Methylation in the Parasitoid Wasp Nasonia vitripennis
用于肺炎链球菌监测的可移植可扩展基因组分析流程:GPS流程 Hung, H. C. H. PDF N/A A Portable and Scalable Genomic Analysis Pipeline for Streptococcus pneumoniae Surveillance: GPS Pipeline
CCA相关细菌对抗抗生素耐药性病原体的潜力:一项基因组调查 Lera-Lozano, D. PDF N/A The Potential of CCA-associated Bacteria to Fight Antimicrobial-Resistant Pathogens: a Genomic Survey
抗原-葡聚糖聚合物的开发用于检测和评估CAR T细胞 Friis, R. PDF N/A Development of antigen-dextramers for detection and evaluation of CAR T cells
药物抗性心脏重编程可缓解多柔比星诱导的小鼠和猪的心脏毒性 Zhang, Y. PDF N/A Cardiac Reprogramming with Drug Resistance Alleviates Doxorubicin-induced Cardiotoxicity in Mice and Pigs