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arXiv

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bioRxiv

标题 作者 PDF链接 代码仓库 Title
惩罚风险任务:在小鼠进行目标导向行为时监测其焦虑状态 Parker, K. E. PDF N/A Punishment Risk Task: Monitoring anxiogenic states during goal directed actions in mice
肿瘤相关巨噬细胞的抗原呈递促使肿瘤浸润T细胞从原始的耗竭状态转变为终末耗竭状态。 Waibl Polania, J. PDF N/A Antigen presentation by tumor-associated macrophages drives tumor-infiltrating T cells from a progenitor exhaustion state to terminal exhaustion
diplo-locus:一个轻量级的工具包,用于在一般二倍体选择下进行时间序列遗传数据的推断和模拟 Cheng, X. PDF N/A diplo-locus: A lightweight toolkit for inference and simulation of time-series genetic data under general diploid selection
映射人类特异性缺失的顺式和反式调控靶基因 Fair, T. PDF N/A Mapping cis- and trans-regulatory target genes of human-specific deletions
不同扰动下转录变异性的遗传基础 Tsuru, S. PDF N/A Genetic properties underlying transcriptional variability across different perturbations
雄性小鼠对口腔内辣椒素引发的先天喜好和厌恶反应 Han, Y. PDF N/A Innate liking and disgust reactions elicited by intraoral capsaicin in male mice
雌二醇的细胞内滞留由乳腺癌细胞中的含GRAM结构域蛋白ASTER-B介导 Kim, H. B. PDF N/A Intracellular Retention of Estradiol is Mediated by GRAM Domain Containing Protein ASTER-B in Breast Cancer Cells
全国范围内的鸟类生物多样性和迁徙声学监测 Bick, A. PDF N/A National-scale acoustic monitoring of avian biodiversity and migration
生物分子凝聚体在相分离的质量守恒反应-扩散系统的实验与理论之间架起了桥梁。 Li, C. PDF N/A Biomolecular condensates bridge experiment and theory of mass-conserving reaction-diffusion systems in phase separation
环状RNA与人类胎盘组织老化和死产中的DNA损伤有关 Arthurs, A. L. PDF N/A Circular RNAs correlate with DNA damage in ageing human placental tissue and in stillbirth
基于人工智能的发现与低温电子显微镜结构阐明的一种KATP通道药物伴侣蛋白 Elsheikh, A. PDF N/A AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone
通过HiCapR映射HIV-1 RNA结构、同源二聚体、长程相互作用及持久性域 Zhang, Y. PDF N/A Mapping HIV-1 RNA Structure, Homodimers, Long-Range Interactions and persistent domains by HiCapR
神经肌肉骨骼建模揭示了感觉运动皮层中适应性学习的肌肉水平神经动力学 DeWolf, T. PDF N/A Neuro-musculoskeletal modeling reveals muscle-level neural dynamics of adaptive learning in sensorimotor cortex
各向异性拉伸使多细胞水螅聚集体中的肌动纤维自组织产生偏倚 Bailles, A. PDF N/A Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates
共享和独特的终身压力源特征及网络连接性预测青少年的焦虑和抑郁 Qu, Y. PDF N/A Shared and unique lifetime stressor characteristics and network connectivity predict adolescent anxiety and depression
基于Transformer的生存结果预测方法 Mellors, T. PDF N/A A Transformer-Based Approach to Survival Outcome Prediction
折叠稀释和稀释液体积对细菌培养中菌落形成单位估计的影响 Jain, M. PDF N/A The impact of fold-dilution and diluent volume on the estimation of colony forming units in a bacterial culture
刺皮动物中顺式调控元件和染色质组织的深度保守揭示了动物基因组的祖先调控特征 Magri, M. S. PDF N/A Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes
肿瘤乳酸脱氢酶C(LDHC)在乳腺癌中的免疫调节作用 Naik, A. PDF N/A Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer
个性化治疗脑膜瘤:肿瘤类器官药物筛选揭示对HDAC1/2i帕比司他的治疗脆弱性 Jungwirth, G. PDF N/A Personalized Medicine for Meningiomas: Drug Screening on Tumor Organoids Exposes Therapeutic Vulnerabilities to HDAC1/2i Panobinostat
DGKα和ζ缺乏导致调节性T细胞功能失调、不稳定及转化为致病性T滤泡辅助细胞,从而触发以IgG1为主的自身免疫反应。 Li, L. PDF N/A DGKα and ζ Deficiency Causes Regulatory T-Cell Dysregulation, Destabilization, and Conversion to Pathogenic T-Follicular Helper Cells to Trigger IgG1-Predominant Autoimmunity
非洲慈鲷鱼肠道中适应性细胞进化的超多样性 Fages, A. PDF N/A Adaptive cellular evolution in the intestinal tracts of hyperdiverse African cichlid fishes
性及应激依赖的基底外侧杏仁核至伏隔核皮质酮释放激素/GABA投射的可塑性,该投射介导奖赏行为 Taniguchi, L. PDF N/A Sex-and Stress-Dependent Plasticity of a Corticotropin Releasing Hormone / GABA Projection from the Basolateral Amygdala to Nucleus Accumbens that Mediates Reward Behaviors
昼夜活动预测亚洲埋葬甲虫Nicrophorus nepalensis的繁殖物候 Chen, H. PDF N/A Circadian Activity Predicts Breeding Phenology in the Asian Burying Beetle Nicrophorus nepalensis
可卡因和安非他明调节的转录本在外侧隔核中的厌食和焦虑作用 Shankhatheertha, A. PDF N/A Anorectic and anxiogenic actions of cocaine- and amphetamine-regulated transcript in the lateral septum
连接梯度的个体独特性是由嵌入网络的复杂性和它们的分散性所驱动的。 Serhan, Y. PDF N/A Individual uniqueness of connectivity gradients is driven by the complexity of the embedded networks and their dispersion
利用钙成像技术对单个神经元对不同任务相关行为状态的选择性进行稳健表征 Huang, H. PDF N/A Robust characterization of selectivity of individual neurons to distinct task-relevant behavioral states using calcium imaging
一种用于自动化评估神经退行性疾病小鼠模型中区域性脑萎缩的工具 Moldenhauer, S. PDF N/A A tool to automate assessment of regional brain atrophy in mouse models of neurodegenerative disease
与肌萎缩侧索硬化症(ALS)相关的共伴侣蛋白DNAJC7通过调节HSF1活性,介导了对蛋白质毒性应激的神经保护作用。 Fleming, A. C. PDF N/A The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity
在知觉决策任务的学习初期,内部状态便开始显现。 Cuturela, L. I. PDF N/A Internal states emerge early during learning of a perceptual decision-making task
戒断初期阻断下丘脑泌素受体1可预防可卡因觅药行为的潜伏,并使多巴胺传递恢复正常 Clark, P. J. PDF N/A Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission
MortX:一个用于小鼠皮质分割和配准的领域泛化基准 Iqbal, A. PDF N/A MortX: A Domain Generalization Benchmark for Mouse Cortex Segmentation and Registration
改造Barnes迷宫用于STARR FIELD痴呆小鼠模型:一个为期4天的实验方案,探究学习速率、记忆保持和认知灵活性。 Bertolli, A. PDF N/A Renovating the Barnes maze for mouse models of Dementia with STARR FIELD: A 4-day protocol that probes learning rate, retention and cognitive flexibility.
基因移动元件在体内介导细胞类型特异的基因组组织和径向基因移动 Lucas, T. PDF N/A Gene mobility elements mediate cell type specific genome organization and radial gene movement in vivo
小鼠和大鼠尾部附器发育过程中Edar和Xedar的差异表达 Wisniewski, S. A. PDF N/A Differential Expression of Edar and Xedar During Mouse and Rat Tail Appendage Development
时间不确定性对标志追踪行为的影响 Kaneko, R. PDF N/A Impact of Temporal Uncertainty on Sign-tracking Behavior
反社会盲穴鱼(Astyanax mexicanus)社会行为的机制 Sekulovski, B. PDF N/A Mechanisms of Social Behavior in the Anti-Social Blind Cavefish (Astyanax mexicanus)
优化镍钛诺导管的超短脉冲激光制备策略以用于血管介入手术 Song, Y. PDF N/A Optimizing femtosecond laser fabricating strategy of Nitinol hypotube for vascular interventional surgery
大肠杆菌可溶性polyA聚合酶生产条件的优化 Oscorbin, I. P. PDF N/A Optimization of conditions for production of soluble E. coli polyA-polymerase
ZBP1与ADAR Z-Alpha结构域的染色质相互作用图谱:基于ChIP-Seq的比较研究 Hamrick, D. PDF N/A Mapping Chromatin Interactions of ZBP1 and ADAR Z-Alpha Domains: A ChIP-Seq Based Comparison
鉴定感染印度奶牛泰勒虫属中与布帕伐醌抗性相关的基因变异。 Musale, P. PDF N/A Identification of genetic variation in genes linked to buparvaquone resistance in Theileria sp infecting dairy cattle in India.
使用片段连接排他性甲基化测序(FLEXseq)富集低输入和片段化DNA的甲基化组 Yu, J. PDF N/A Enriched Methylomes of Low-input and Fragmented DNA Using Fragment Ligation EXclusive Methylation Sequencing (FLEXseq)
在真核生物蛋白质组中发现多种嵌合肽,为镶嵌翻译假说的实验验证奠定了基础 Cakir, U. PDF N/A Discovery of diverse chimeric peptides in a eukaryotic proteome sets the stage for the experimental proof of the mosaic translation hypothesis
使用分子动力学模拟对修饰寡核苷酸进行热力学参数估计 Park, S. W. PDF N/A Thermodynamic Parameter Estimation for Modified Oligonucleotides Using Molecular Dynamics Simulations
影响复合物I功能的mtDNA点突变m.10191T>C的发病机制是一个多因素过程,导致线粒体代谢重塑。 Ahmadi, Z. A. PDF N/A Pathogenesis of mtDNA point mutation m.10191T>C affecting complex I function is a multifactorial process leading to metabolic remodeling of mitochondria
G-四链体拓扑结构决定了富含鸟嘌呤的生物活性寡核苷酸的功能结果 Kharel, P. PDF N/A G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides
新型2-花生四烯酰甘油类似物诱导的两步细胞死亡及其在人乳腺癌细胞中受溶血磷脂酰肌醇调节的作用 Akimov, M. G. PDF N/A The Two-Step Cell Death Induction by the New 2-Arachidonoyl Glycerol Analog and its Modulation by Lysophosphatidylino-sitol in Human Breast Cancer Cells
烟草中环肽的出现与消失揭示了植物代谢演化的动态与机制 Suh, E. M. PDF N/A The emergence and loss of cyclic peptides in Nicotiana illuminate dynamics and mechanisms of plant metabolic evolution
通过无监督随机森林实现蛋白质构象表示的无偏学习 Sahil, M. PDF N/A Unbiased learning of protein conformational representation via unsupervised random forest
通过靶向神经氨酸酶活性位点,人类抗体广泛保护流感病毒的结构基础:CDR H3中重复模体的应用 Jo, G. PDF N/A Structural basis of broad protection against influenza virus by a human antibody targeting the neuraminidase active site via a recurring motif in CDR H3
节俭的B细胞受体体细胞超突变广义模型 Sung, K. PDF N/A Thrifty wide-context models of B cell receptor somatic hypermutation
有机和无机氮的协同转化促进了土壤微生物的繁殖,并在融雪期间增加了氮的保留。 Sorensen, P. PDF N/A Coordinated organic and inorganic nitrogen transformations fuel soil microbial blooms and increase nitrogen retention during snowmelt
CpoS四聚体的形成促进了沙眼衣原体感染期间Inc-Inc相互作用。 Tijerina, X. PDF N/A Tetramer formation of CpoS facilitates Inc-Inc interactions during Chlamydia trachomatis infection
评估oxathiapiprolin作为治疗贝壳杉枯死病潜在药物的植物内效力 Robinson, H. F. PDF N/A Assessing the in planta efficacy of oxathiapiprolin as a potential treatment for kauri dieback disease
miRNAs在调节Nrf1和Nrf2在肝细胞癌上皮-间质转化中不同作用的关键机制 Chen, J. PDF N/A The mechanisms by which miRNAs critically contribute to differential roles of Nrf1 and Nrf2 in modulating the epithelial-mesenchymal transformation of hepatocellular carcinoma
NuMA机械性地独立于其伙伴动力蛋白(dynein)强化纺锤体。 Cho, N. H. PDF N/A NuMA mechanically reinforces the spindle independently of its partner dynein
高质量的中国白松露基因组和新颖的基于化石校准的盘菌纲分歧估计揭示了真松露基因组进化的速度和模式 Martelossi, J. PDF N/A The high quality Chinese white truffle genome and novel fossil-calibrated estimate of Pezizomycetes divergence reveal the tempo and mode of true truffles genome evolution
CRISPRa介导的与遗传性视网膜营养不良相关的基因在急性分离的人类细胞中的激活,用于诊断目的 Weber, V. J. PDF N/A CRISPRa-mediated activation of genes associated with inherited retinal dystrophies in acutely isolated human cells for diagnostic purposes
TEAL-seq:目标表达分析测序 Doing, G. PDF N/A TEAL-seq: Targeted Expression Analysis Sequencing
利用深度神经网络全面枚举癌症干细胞样细胞的异质性 Chowdhury, D. PDF N/A Comprehensive Enumeration of Cancer Stem-like Cell Heterogeneity Using Deep Neural Network
来自毛里求斯食蟹猕猴的多条全长纯合IGH单体型 Olubo, S. PDF N/A Multiple full-length homozygous IGH haplotypes from Mauritian cynomolgus macaques
MultiPopPred:一种跨种族疾病风险预测方法,及其在南亚人群中的应用 Kamal, R. PDF N/A MultiPopPred: A Trans-Ethnic Disease Risk Prediction Method, and its Application to the South Asian Population
长读长宏基因组样本中微生物污染读段的鉴定与缓解 Ayala Montano, S. PDF N/A Identification and Mitigation of microbial contaminant reads from long-read metagenomic samples
通过重建亲代和子代链信息来纠正用于稀有等位基因检测的PCR衍生文库中的错误 Lim, H. PDF N/A Correcting errors in PCR-derived libraries for rare allele detection by reconstructing parental and daughter strand information
HyperMPNN - 一种从嗜热菌中学习到的设计耐热蛋白质的通用策略 Ertelt, M. PDF N/A HyperMPNN - A general strategy to design thermostable proteins learned from hyperthermophiles
利用基因组数据进行多类型种群轨迹的贝叶斯系统发育动力学推断 Vaughan, T. G. PDF N/A Bayesian phylodynamic inference of multi-type population trajectories using genomic dat
靶向FAK和MEK的药物组合克服了胶质母细胞瘤的肿瘤异质性 Furqan, M. PDF N/A Drug combinations targeting FAK and MEK overcomes tumour heterogeneity in glioblastoma
LNS8801:一种适合临床开发的G蛋白偶联雌激素受体的对映体纯激动剂 Natale, C. A. PDF N/A LNS8801: An enantiomerically pure agonist of the G protein-coupled estrogen receptor suitable for clinical development
MUC5B启动子变异导致非纤维化肺中的蛋白质组变化 HERRERA, J. A. PDF N/A The MUC5B promoter variant results in proteomic changes in the non-fibrotic lung
实施梭菌属鲁氏菌基因组规模模型以提升合成气发酵 Scott, W. T. PDF N/A Implementation of a Clostridium luticellarii genome-scale model for upgrading syngas fermentations

medRxiv

标题 作者 PDF链接 代码仓库 Title
认知能力与心理健康之间的关系,表现为在神经和基因水平分析中的认知能力 Wang, Y. PDF N/A The relationship between cognitive abilities and mental health as represented by cognitive abilities at the neural and genetic levels of analysis
多性状全基因组分析发现了心力衰竭的新风险位点及候选药物 Yu, Z. PDF N/A Multi-trait genome-wide analysis identified novel risk loci and candidate drugs for heart failure
塑造年轻成年女性阴道微生物群长期群落动态的因素 Kamiya, T. PDF N/A Factors shaping vaginal microbiota long-term community dynamics in young adult women
通过组织学信息引导的体内扩散磁共振成像实现临床可行的肝肿瘤细胞大小测量 Grussu, F. PDF N/A Clinically feasible liver tumour cell size measurement through histology-informed in vivo diffusion MRI
跨平台临床蛋白质组学:使用夏里特开放标准血浆蛋白质组学(OSPP) Wang, Z. PDF N/A Cross-platform Clinical Proteomics using the Charite Open Standard for Plasma Proteomics (OSPP)
多发性骨髓瘤药物疗效分析 Matov, A. PDF N/A Analysis of Multiple Myeloma Drug Efficacy
用于肾病病程中生存预测和患者亚型分类的时间依赖性LSTM模型 Shi, P. PDF N/A Time-dependent LSTM for Survival Prediction and Patient Subtyping in Kidney Disease Trajectory
吡喹酮分发对学龄儿童并殖吸虫病流行病学的影响:一项在喀麦隆最严重疫区的横断面研究 Cheuyem, F. Z. L. PDF N/A Impact of Praziquantel Distribution on the Epidemiology of Paragonimiasis Among School-Aged Children: A Cross Sectional Study in the Most Endemic Focus in Cameroon
口腔健康问题的自我用药行为:一项基于斯里兰卡社区的横断面研究 Gammulle, K. A. PDF N/A Self-medication practices for oral health problems: A community-based cross-sectional study in Sri Lanka
对NMDA受体抗体脑炎和妊娠的临床数据及报告质量的系统性回顾 Harris, S. L. PDF N/A A systematic review of clinical data and reporting quality in NMDAR-antibody encephalitis and pregnancy
AI驱动的对话代理增强了精准医学研究中的临床和基因组数据整合 Yang, E.-W. PDF N/A AI-driven conversational agent enhances clinical and genomic data integration for precision medicine research
多音乐多领域干预,包括社区老年人合唱练习:脑源性神经营养因子(BDNF)唾液生物标志物、听力学和神经心理学参数的研究方案 Lippolis, M. PDF N/A The MultiMusic multidomain intervention including choral practice in community-dwelling older people: A study protocol for Brain-Derived Neurotrophic Factor (BDNF) salivary biomarkers, audiometric and neuropsychological parameters
南非接受抗逆转录病毒治疗(ART)的HIV患者在最初六个月内脱离护理的驱动因素:一项混合方法研究 Maskew, M. PDF N/A Drivers of disengagement from care during the first six months on antiretroviral therapy for HIV in South Africa: a mixed-methods study
FMT恢复复发性艰难梭菌感染患者的结肠蛋白质生物合成和细胞增殖 Moreau, G. B. PDF N/A FMT Restores Colonic Protein Biosynthesis and Cell Proliferation in Patients with Recurrent Clostridioides difficile Disease
澳大利亚成年人使用直接作用抗病毒药物治疗丙型肝炎的财务激励措施(早期丙型肝炎治疗获取目标激励措施的方法评估与优化:MOTIVATE-C):统计分析计划 Jones, M. PDF N/A Financial incentives to motivate treatment for hepatitis C with direct acting antivirals among Australian adults (The Methodical evaluation and Optimisation of Targeted IncentiVes for Accessing Treatment of Early-stage hepatitis C: MOTIVATE-C): Statistical Analysis Plan
评估ICD-10编码方法用于追踪美国涉及赛拉嗪的过量死亡事件 Friedman, J. R. PDF N/A Assessing an ICD-10 Code Approach for Tracking Xylazine-Involved Overdose Deaths in the United States
炎症细胞因子、代谢物与心律失常之间的因果关系:一项孟德尔随机化研究 Xie, f. y. PDF N/A Causal relationship between inflammatory cytokines, metabolites and arrhythmia: a mendelian randomization study
基于机器学习的心房颤动消融结果高风险模式的识别 Oloko-Oba, M. PDF N/A Machine Learning-Based Identification of High-Risk Patterns in Atrial Fibrillation Ablation Outcomes
利用超声心动图人工智能对心包积液和心脏压塞进行自动评估 Chiu, I.-M. PDF N/A Automated Evaluation for Pericardial Effusion and Cardiac Tamponade with Echocardiographic Artificial Intelligence
量化和可视化急诊科医生工作流程:一项观察性时间-动作研究的结果 Henreid, A. J. PDF N/A Quantifying and Visualizing Emergency Physician Workflow: Results of an Observational Time-Motion Study
莱索托多药耐药性结核病的社会人口学决定因素:一项病例对照研究 Yahaya, J. Y. PDF N/A Sociodemographic Determinants of Multidrug-Resistant Tuberculosis in Lesotho: A Case-Control Study
疫情初期纬度、日照时长和维生素D水平与COVID-19发病率和死亡率的关联:187个国家的全球分析 Mogire, R. M. PDF N/A Early Pandemic Associations of Latitude, Sunshine Duration, and Vitamin D Status with COVID-19 Incidence and Fatalities: A Global Analysis of 187 Countries
GLP-1受体激动剂的替代给药方案可能降低成本并保持疗效 Cengiz, A. PDF N/A Alternative dosing regimens of GLP-1 receptor agonists may reduce costs and maintain efficacy
开发实践绩效提升工具,一项用于评估初级保健结构和流程的实践层面调查 Kwok, L. PDF N/A Development of the Tool for Advancing Practice Performance, a practice-level survey to assess primary care structures and processes
利用深度神经网络和语言模型预测精神分裂症长期住院风险 Bao, Y. PDF N/A Leveraging Deep Neural Network and Language Models for Predicting Long-Term Hospitalization Risk in Schizophrenia
精准肿瘤学研究机会:爱尔兰癌症患者对生物样本和基因组数据共享的看法 O'Grady, S. PDF N/A Research opportunities in precision oncology: Perspectives on biospecimen and genomic data sharing from adults with cancer in Ireland
马里巴马科在新冠疫情期间的家庭脆弱性与应对:评估与家庭困境相关的社会人口因素 Muir, J. A. PDF N/A Household Vulnerability and Coping Amid the COVID-19 Pandemic in Bamako, Mali: Assessing Sociodemographic Factors Associated with Household Hardships
基于推断的时间分辨皮质稳定性与混沌分析用于局灶性癫痫发作 Zhao, Y. PDF N/A Inference-based time-resolved cortical stability and chaos analysis for focal epileptic seizures
尼日利亚某大学医院门诊药房服务满意度:一项横断面研究 Agu, M. C. PDF N/A Clients Satisfaction With The Services Of An Outpatient Pharmacy At A University Hospital In Nigeria: A Cross-Sectional Study
乌干达社区对子痫前期的理解、经验、认知和意识。Mbale市的一项探索性研究。 Kawala, E. K. PDF N/A Community understanding, experiences, perceptions and awareness about preeclampsia in Uganda. A Exploratory study in Mbale city
尼日利亚5岁以下儿童中,比较季节性疟疾化学预防与含或不含维生素A补充的成本分析 Oresanya, O. B. PDF N/A A cost analysis comparing Seasonal Malaria Chemoprevention with and without Vitamin A Supplementation among under-5 children in Nigeria
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