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BioRxiv 2024-12-03 Papers

标题 作者 PDF链接 代码仓库 Title
不太本地化:玉米和类蜀黍趋同适应的群体遗传学。 Tittes, S. PDF N/A Not so local: the population genetics of convergent adaptation in maize and teosinte.
果蝇个体气味偏好的神经相关性 Churgin, M. PDF N/A A neural correlate of individual odor preference in Drosophila
在小鼠发育中的大脑皮层中,急性产前酒精暴露后DNA甲基化和转录组的即时扰动 DUCHATEAU, A. PDF N/A Immediate perturbation of DNA methylation and transcriptome upon acute prenatal alcohol exposure in the mouse developing brain cortex
雌性北棕林鸫(Troglodytes aedon)在对抗三种模拟捕食者时的风险评估 Eggleston, R. C. PDF N/A Risk assessment during nest defense against three simulated predators by female northern house wrens (Troglodytes aedon)
xTrimoPGLM:统一100亿规模预训练变压器,用于解读蛋白质语言 Chen, B. PDF N/A xTrimoPGLM: Unified 100B-Scale Pre-trained Transformer for Deciphering the Language of Protein
通过果蝇模型识别心血管疾病与失眠之间的新关联,该模型基于一个多效性全基因组关联研究位点的基因 Abou Daya, F. PDF N/A Identifying novel links between cardiovascular disease and insomnia by Drosophila modeling of genes from a pleiotropic GWAS locus
抑制NINJ1依赖的质膜破裂可防止炎症小体诱导的血液凝固和炎症 Wu, C. PDF N/A Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasomeinduced blood coagulation and inflammation
常染色体显性多囊肾病(ADPKD)是由多囊蛋白-1(Polycystin-1)中的错义变异引起的,这些变异破坏了细胞表面定位或多囊蛋白通道功能。 Ha, K. PDF N/A ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function
视觉和触觉持续时间再现中的准确性反馈和延迟适应效应 Chen, L. PDF N/A Accuracy Feedback and Delay Adaptation Effects in Visual and Tactile Duration Reproduction
通过体内注射和电穿孔裸露mRNA恢复患有少弱畸精子症小鼠的精子生育力 Vilpreux, C. PDF N/A Sperm fertility restoration in mice suffering from oligo-astheno-teratozoospermia by in vivo injection and electroporation of naked mRNA
DNA甲基组调控丁香假单胞菌的毒力和代谢 Huang, J. PDF N/A DNA Methylome Regulates Virulence and Metabolism in Pseudomonas syringae
真菌蛋白Jps1通过直接的磷脂酰肌醇相互作用促进非常规蛋白质分泌。 Dali, S. PDF N/A The fungal protein Jps1 facilitates unconventional protein secretion through a direct phosphoinositide interaction
细胞周期和年龄相关的小鼠染色体刚性调节 Liu, N. PDF N/A Cell-cycle and Age-Related Modulations in Mouse Chromosome Stiffness
果蝇科温度偏好行为的演变 Kafle, T. PDF N/A Evolution of temperature preference behaviour among drosophilids
基于宏转录组学的感染期间患者特异性尿液微生物组的代谢建模 Josephs-Spaulding, J. PDF N/A Metatranscriptomics-based metabolic modeling of patient-specific urinary microbiome during infection
自然行为中视觉运动协调的低维表示 Keshava, A. PDF N/A Low-Dimensional Representations of Visuomotor Coordination for Natural Behavior
一种可调且多功能的近红外荧光化学遗传报告器 El Hajji, L. PDF N/A A tunable and versatile chemogenetic near infrared fluorescent reporter
行走的果蝇中运动统计的抑制性控制 Gattuso, H. PDF N/A Inhibitory control of locomotor statistics in walking Drosophila
一种多状态捕获-重捕模型,用于估计北大西洋露脊鲸的繁殖情况。 Linden, D. W. PDF N/A A multistate capture-recapture model to estimate reproduction of North Atlantic right whales
基于能量的适应性免疫 repertoire 行为系统建模:细胞增殖与体细胞超突变过程研究 Chen, Y. PDF N/A Energy-Based Systematic Modeling of Adaptive Immune Repertoire Behavior: Study on Cell Proliferation & Somatic Hypermutation process
Q175亨廷顿病模型小鼠中mTOR抑制促进神经元自噬及突变亨廷顿蛋白清除 Stavrides, P. PDF N/A mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
斑马鱼肠道中的蛋白质吸收受到富含溶酶体的肠细胞与微生物群之间相互作用的调控。 Childers, L. PDF N/A Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome
分流细胞的瞬态和动态特性源自其行为。 Chaix-Echel, N. PDF N/A The transient and dynamic nature of splitter cells derive from behavior
结构变异对玉米表型变异有贡献 Catlin, N. S. PDF N/A Structural variants contribute to phenotypic variation in maize
在不增加训练或数据的情况下提高逆折叠模型在蛋白质稳定性预测中的表现 Dutton, O. PDF N/A Improving Inverse Folding models at Protein Stability Prediction without additional Training or Data
利用时间维度和光谱维度实现多样性热带森林中的综合单木树种制图 Ball, J. G. C. PDF N/A Towards comprehensive individual tree species mapping in diverse tropical forests by harnessing temporal and spectral dimensions
细胞拥挤会诱导TRPV4的抑制及其向质膜的重新定位,暗示了促进侵袭的细胞体积减少机械转导途径。 Bu, X. PDF N/A Cell crowding induces TRPV4 inhibition and its relocation to plasma membranes, implicating pro-invasive cell volume reduction mechanotransduction pathway
利用动力学信息提高基因组规模代谢模型的准确性 Lazaro Ibanez, J. PDF N/A Enhancing the accuracy of genome-scale metabolic models with kinetic information
错位视网膜轴突在白化小鼠的视觉丘脑中诱导出一种突触独立的子回路。 McCracken, S. PDF N/A Mistargeted retinal axons induce a synaptically independent subcircuit in the visual thalamus of albino mice.
两个相互作用细胞之间对齐机制的动力学分析 Leech, V. PDF N/A A dynamical analysis of the alignment mechanism between two interacting cells
基于结构的RyR通道操作机制:钙离子和镁离子的作用 Zahradnikova, A. PDF N/A Structure-based mechanism of RyR channel operation by calcium and magnesium ions
基因组数据显示,非洲各地的血吸虫(Schistosoma haematobium)种群存在南北分化及基因渐渗历史。 Platt, R. N. PDF N/A Genomic data reveal a north-south split and introgression history of blood fluke (Schistosoma haematobium) populations from across Africa
解决功能神经影像学中的不一致性:一种可复制的、数据驱动的多尺度功能图谱,用于标准脑网络 Jensen, K. M. PDF N/A Addressing inconsistency in functional neuroimaging: A replicable data-driven multi-scale functional atlas for canonical brain networks
一种综合方法,用于提取经历液-液相分离的球状蛋白质的旋转动力学 Gendreizig, D. PDF N/A A combined approach to extract rotational dynamics of globular proteins undergoing liquid-liquid phase separation
纤维化中异位肺泡基底细胞相对于气道基底细胞的特征 Blumer, S. PDF N/A Characteristics of ectopic alveolar basal cells relative to airway basal cells in fibrosis
inPhase - 一种简单、准确且快速的方法来确定蛋白质凝聚相图 Fritsch, A. W. PDF N/A inPhase - A simple, accurate and fast approach to determine phase diagrams of protein condensates
有丝分裂后依赖PP2A-Ankle2的核重构机制 Li, J. PDF N/A Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis
一种肿瘤胚胎学方法揭示了SoxC驱动的结肠发育和癌症调控机制 Dalessi, T. PDF N/A An oncoembryology approach uncovers SoxC-driven regulation of colon development and cancer
淀粉样前体蛋白(Amyloid Beta Precursor Protein)有助于短命的绿松石鳉鱼(Nothobranchius furzeri)的脑老化和学习能力下降。 de Bakker, D. E. M. PDF N/A Amyloid Beta Precursor Protein contributes to brain aging and learning decline in short-lived turquoise killifish (Nothobranchius furzeri)
由祖先SARS-CoV-2印记的B细胞在免疫回忆中产生广谱的沙贝病毒中和能力 Chen, X. PDF N/A B cells imprinted by ancestral SARS-CoV-2 develop pan-sarbecovirus neutralization in immune recalls
TreeFormer:一种基于Transformer的树重排操作,用于系统发育重建 Ly-Trong, N. PDF N/A TreeFormer: A transformer-based tree rearrangement operation for phylogenetic reconstruction
基于片段的小分子抑制剂开发,靶向结核分枝杆菌胆固醇代谢 Kavanagh, M. E. PDF N/A Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism
ERP和神经振荡能否用于在一个生态有效的运动模型中区分熟练和非熟练玩家的表现? Winstanley, M. PDF N/A Can ERPs and neural oscillations be used to differentiate skilled and unskilled player performance in an ecologically valid sporting model?
药物的环境影响:对近期关于水生浓度及可预测效应数据的证据映射回顾 Renda, F. PDF N/A The environmental impact of pharmaceuticals: an evidence-mapping review of recent data on aquatic concentrations and predictable effects
甲型流感病毒的转录产生加帽的cRNA,这些cRNA能够激活RIG-I。 Elshina, E. PDF N/A Influenza A virus transcription generates capped cRNAs that activate RIG-I
一种简单的新替代线性-二次模型(以及LQ模型的来源) Bilinsky, L. PDF N/A A simple new alternative to the linear-quadratic model (and where the LQ model comes from)
对Diversity Outbred小鼠研究中寿命的分析确定了多个与长寿相关的位点 Mullis, M. N. PDF N/A Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci
原位整合多孔聚乙烯纳米膜与伤口渗出液以实现无痕愈合 Yuan, S. PDF N/A In Situ Integration of Porous Polyethylene Nanomembrane with Wound Exudates for Scarless Healing
高分辨率分析揭示了转基因的转录和翻译调控的耦合关系 Peterman, E. L. PDF N/A High-resolution profiling reveals coupled transcriptional and translational regulation of transgenes
广泛存在的肠杆菌过氧化物酶封装体的结构和生化特性 Ubilla-Rodriguez, N. C. PDF N/A Structural and biochemical characterization of a widespread enterobacterial peroxidase encapsulin
对动力蛋白-动力蛋白激活蛋白-NuMA复合物的激活和调控的结构与功能解析 Aslan, M. PDF N/A Structural and functional insights into activation and regulation of the dynein-dynactin-NuMA complex
过度活跃的神经网络促进阿尔茨海默病小鼠模型中的tau蛋白扩散 Barbour, A. J. PDF N/A Hyperactive neuronal networks facilitate tau spread in an Alzheimer's disease mouse model
果蝇对细菌肽聚糖的感知反应整合了正向和负向信号 Montanari, M. PDF N/A Drosophila's sensory responses to bacterial peptidoglycan integrates positive and negative signals
哺乳动物增强子和全基因组关联研究(GWASs)主要在基因附近发挥作用,很少跨越活跃基因。 Choudhary, C. PDF N/A Mammalian enhancers and GWASs act proximally and seldom skip active genes
玉米裸粒的古老起源 Fairbanks, R. A. PDF N/A An ancient origin of the naked grains of maize
玉米及相关物种中生殖屏障的分子进化 Cryan, E. PDF N/A Molecular evolution of a reproductive barrier in maize and related species
根癌农杆菌A4衍生菌株在烟草和其它茄科植物中实现超高效瞬时基因表达 Lopez-Agudelo, J. C. PDF N/A Rhizobium rhizogenes A4-derived strains mediate hyper-efficient transient gene expression in Nicotiana benthamiana and other solanaceous plants
机械应力引导气孔分裂,形成组织尺度的排列。 Serra, L. PDF N/A Mechanical stress orients stomata division to form tissue scale alignments.
番茄疫霉病潜在生物防治剂的时空化学研究 Robinson, J. Y. PDF N/A Spatiochemical Investigation of Potential Biocontrol Agents Against Phytophthora capsici Infection in Tomato
由亚麻锈病菌Melampsora lini介导的效应蛋白向植物细胞的转运 Zhang, X. PDF N/A Translocation of effector proteins into plant cells by the flax rust pathogen Melampsora lini
通过宿主到群体的计算机病毒进化,利用深度学习实现生成式流行突变预测 Liu, X. PDF N/A Deep-learning-enabled generative prevalent mutation prediction through host-to-herd in silico virus evolution
MAAPE:一种模块化蛋白质嵌入进化分析方法 Wang, X. PDF N/A MAAPE: A Modular Approach to Evolutionary Analysis of Protein Embeddings
昆虫对植物挥发性物质的气相色谱-耦合电位图检测(GC-EAD)的定量分析 Byers, K. J. R. P. PDF N/A Quantitative analysis of gas chromatography-coupled electroantennographic detection (GC-EAD) of plant volatiles by insects
植物机械应答中细胞骨架和质体骨架蛋白的功能、生物素化蛋白质组学和生物信息学分析 WU, K. PDF N/A Functional, Biotinylproteomic and Bioinformatic Analysis of Both Cytoskeletal and Plastoskeletal Proteins in Plant Mechanoresponse
保守效应因子支撑了从苔藓中分离出的假单胞菌在不同植物中的致病性 Robinson, K. PDF N/A Conserved effectors underpin the virulence of liverwort-isolated Pseudomonas in divergent plants
性别偏倚基因表达在性对抗选择和性限制选择下的表现 Wiberg, R. A. W. PDF N/A Sex-biased gene expression under sexually antagonistic and sex-limited selection
可解释人工智能引导的植物中选择性siRNA积累的新型蛋白质-RNA相互作用框架的鉴定 Enoki, N. PDF N/A Explainable AI-guided identification of a novel protein-RNA interactive frame for selective siRNA accumulation in plants
生成式人工智能的分化:大学生背景如何影响其生成式AI素养 Jiang, J. PDF N/A Generative AI divide: How College Students' Backgrounds Affect Their Gen AI Literacy
TET敲除细胞在多能态之间转换,并表现出过早的生殖系进入。 Chambers, I. PDF N/A TET knockout cells transit between pluripotent states and exhibit precocious germline entry
性二态性与间性关联:模型是否支持直觉? Puixeu, G. PDF N/A The relationship between sexual dimorphism and intersex correlation: do models support intuition?
解开适应性与非适应性过程在Coenonympha蝴蝶生殖隔离进化中的贡献。 Capblancq, T. PDF N/A Untangling the contribution of adaptive versus non-adaptive processes in the evolution of reproductive isolation between Coenonympha butterflies.
数字DNA系统揭示了单向遗传相对于“拉马克式”遗传的优越性 Shiju, A. PDF N/A A digital DNA system reveals the superiority of unidirectional inheritance over 'Lamarckian' inheritance
通过mitology R包解析转录组数据中的线粒体活性 Pirrotta, S. PDF N/A Dissect mitochondrial activity by transcriptome data with mitology R package
人类糖皮质激素受体变异体rs6190促进血液胆固醇水平和动脉粥样硬化的发生。 Durumutla, H. B. PDF N/A The human glucocorticoid receptor variant rs6190 promotes blood cholesterol and atherosclerosis
雌激素信号在Reprimo谱系细胞中的性别特异性体温调节作用 Park, J. W. PDF N/A Sex-specific thermoregulatory effects of estrogen signaling in Reprimo lineage cells
光量影响拟南芥幼叶对寒冷的早期反应和冷适应 Luklova, M. PDF N/A Light quantity impacts early response to cold and cold acclimation in young leaves of Arabidopsis
拟南芥花粉管向性调控因子PCP-B与RALF23/33竞争结合的结构基础 Bhalla, H. PDF N/A Structural Insights into Competitive Binding Dynamics between RALF23/33 and PCP-B in Brassicaceae Pollination
单核测序揭示了Moricandia arvensis中束鞘细胞在C3-C4中间型十字花科植物光呼吸穿梭中的功能 Triesch, S. PDF N/A Single-nuclei sequencing of Moricandia arvensis reveals bundle sheath cell function in the photorespiratory shuttle of C3-C4 intermediate Brassicaceae
从头设计的pMHC结合剂促进T细胞介导的癌细胞杀伤 Johansen, K. H. PDF N/A De novo designed pMHC binders facilitate T cell induced killing of cancer cells
一个评分统治所有:基于GWAS汇总统计的正则化集成多基因风险预测 Zhao, Z. PDF N/A One score to rule them all: regularized ensemble polygenic risk prediction with GWAS summary statistics
犬持续性苗勒管综合征:对AMH和AMHR2基因组织的新见解 Krzeminska, P. PDF N/A Persistent Mullerian duct syndrome in dogs: a new insight into organization of AMH and AMHR2 genes
移植后间充质细胞的单细胞多组学分析揭示了肺纤维化的分子特征及潜在调控因子 Lu, L. PDF N/A Single-cell multi-omic analysis of post-transplant mesenchymal cells reveals molecular signatures and putative regulators of lung fibrosis
移植后间充质细胞的单细胞多组学分析揭示了肺纤维化的分子特征及潜在调控因子 Lu, L. PDF N/A Single-cell multi-omic analysis of post-transplant mesenchymal cells reveals molecular signatures and putative regulators of lung fibrosis
中性粒细胞在实验性牙周炎中驱动性别二态性 Martin, K. PDF N/A Neutrophils drive sexual dimorphism in experimental periodontitis
环境毒素衍生的α-突触核蛋白对肠神经-上皮相互作用的性别特异性影响 Templeton, H. N. PDF N/A Sex specific effects of environmental toxin-derived alpha synuclein on enteric neuronal-epithelial interactions
早期接触西方饮食会加剧雌性小鼠的视觉结果。 Meseguer, D. PDF N/A Early exposure to Western diet exacerbates visual outcomes in female mice.
探索类胡萝卜素对致病性尖孢镰刀菌(Fusarium oxysporum f.sp. lini)和内生菌Fo47菌株的影响 Kochneva, Y. PDF N/A Exploring the Impact of Apocarotenoids on Pathogenic Fusarium oxysporum f.sp. lini and Endophytic Fo47 strains
调节APC/C调控因子SlSAMBA的活性可提高番茄果实的糖分和抗氧化物质含量 de Oliveira, P. N. PDF N/A Modulating activity of the APC/C regulator SlSAMBA improves the sugar and antioxidant content of tomato fruits
去除表皮蜡质对角质层蜡质沉积速率没有影响,成熟桂樱叶的角质层蜡质沉积速率是恒定的。 Janova, J. PDF N/A Removal of epicuticular wax has no effect on the rate of cuticular wax deposition, which is constant in mature cherry laurel leaves
多功能的IL-21+ IFNg+ T滤泡辅助细胞有助于检查点抑制剂糖尿病的发生,并可通过JAK抑制剂疗法进行靶向治疗。 Huang, N. PDF N/A Polyfunctional IL-21+ IFNg+ T follicular helper cells contribute to checkpoint inhibitor diabetes mellitus and can be targeted by JAK inhibitor therapy
改进人工智能与现有生态推断工作流程的整合 Cowans, A. PDF N/A Improving the integration of AI into existing ecological inference workflows
伊朗希尔卡尼亚森林中丛林猫的车辆碰撞风险建模:车辆碰撞预防指南 Ashoori, A. PDF N/A Modeling vehicle collision risk for the jungle cat in the Hyrcanian forests of Iran: A guide for vehicle collision prevention
量化单细胞数据中的病理进展 Khan, S. R. PDF N/A Quantifying Pathological Progression from Single-Cell Data
C2AM-Unet:用于视网膜血管分割的坐标与通道注意力混合灵活架构 Zhang, J. PDF N/A C2AM-Unet: Coordinate and Channel Attention Mixing Flexible Architecture for Retinal Vessel Segmentation
亚马逊药用植物中潜在的抗病毒和免疫调节化合物 Napoleao, S. M. d. S. PDF N/A Potential antiviral and immunomodulatory Amazonian medicinal plant compounds
结构趋同和水介导的底物模拟使人类抗体能够广泛抑制神经氨酸酶 Lederhofer, J. PDF N/A Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies
健康人体免疫系统和微生物群的协调变化与持续性干扰素状态有关。 Babdor, J. PDF N/A Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states
单细胞基因表达的动力学模式可区分小鼠对减毒活疫苗和灭活黄热病疫苗的细胞反应 Chatterjee, B. PDF N/A Kinetic patterns of single cell gene expression discriminate between the murine cellular responses to live attenuated and inactivated Yellow Fever vaccines
从公民科学和深度学习对珊瑚礁进行大规模勘察 Lawson, C. L. PDF N/A Broadscale reconnaissance of coral reefs from citizen science and deep learning
波卡:一只负载比高达6847%的死灵机器人甲虫 Tsvetkov, Y. PDF N/A Poka: a necro-robot beetle with a measured payload ratio of 6847%
核苷酸GPT:基于序列的深度学习预测核亚区室相关基因组结构 Mclaughlin, S. M. PDF N/A Nucleotide GPT: Sequence-Based Deep Learning Prediction of Nuclear Subcompartment-Associated Genome Architecture
重塑乳腺癌肝转移局部治疗格局:一种新型瘤内p21靶向经皮疗法可提高BALB/c小鼠接种4T1三阴性乳腺癌细胞后的生存率。 Margulies, B. S. PDF N/A Reshaping the Landscape of Locoregional Treatments for Breast Cancer Liver Metastases: A novel, intratumoral, p21-targeted percutaneous therapy increases survival in BALB/c mice inoculated with 4T1 triple negative breast cancer cells in the liver.
TLR7/8激动剂INI-4001增强了Powassan病毒样颗粒疫苗的免疫原性。 Crawford, M. W. PDF N/A The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine
浮游牡蛎幼虫在复杂的感官环境中优化定居决策 Schmidlin, S. PDF N/A Planktonic oyster larvae optimize settlement decisions in complex sensory landscapes
新型Hybprinter-SAM的开发:用于具有图案化和局部生化信号的功能梯度组织工程构建体 Li, J. PDF N/A Development of a Novel Hybprinter-SAM for Functionally Graded Tissue Engineering Constructs with Patterned and Localized Biochemical Signals
体内在线无标记监测光疗过程中异质性氧利用率,实时超声引导光声成像 Langley, A. PDF N/A In vivo Online label-free monitoring of heterogenous oxygen utilization during phototherapy with real-time ultrasound guided photoacoustic imaging
ReSCU-Nets:用于多维显微镜数据分割的递归U-Nets Hawkins, R. PDF N/A ReSCU-Nets: recurrent U-Nets for segmentation of multidimensional microscopy data
AlphaPulldown2 - 一种用于高通量结构建模的通用流程 Molodenskiy, D. PDF N/A AlphaPulldown2 - A General Pipeline for High-Throughput Structural Modeling
在单细胞和空间组学数据中检测亚群的度量标准 Luo, S. PDF N/A On metrics for subpopulation detection in single-cell and spatial omics data
针对G蛋白偶联受体的特定状态多肽设计 Xue, Y. PDF N/A State-specific Peptide Design Targeting G Protein-coupled Receptors
深度学习方法在RNA三级结构预测中的比较综述 Martinovic, I. PDF N/A A Comparative Review of Deep Learning Methods for RNA Tertiary Structure Prediction
ACE:一种用于单细胞镶嵌整合的多功能对比学习框架 Yan, X. PDF N/A ACE: a versatile contrastive learning framework for single-cell mosaic integration
VBayesMM:用于优先处理高维微生物组多组学数据重要关系的变化贝叶斯神经网络 Dang, T. PDF N/A VBayesMM: Variational Bayesian neural network to prioritize important relationships of high-dimensional microbiome multiomics data
细胞类型特异性表观基因组亚型分类提高了癌症预后分层的准确性。 Luo, Q. PDF N/A Cell-type specific subtyping of epigenomes improves prognostic stratification of cancer
通过内部驱动的定向力实现细胞片层形状转变 Huang, J. PDF N/A Cell-sheet shape transformation by internally-driven, oriented forces
利用大型语言模型解决空间转录组学数据解读的复杂性 Khan, T. PDF N/A Tackling the Complexity of Spatial Transcriptomics Data Interpretation with Large Language Models
通过机械疗法和超声波穿透技术优化实体瘤的治疗效果 Koutsi, M. PDF N/A Optimizing therapeutic outcomes with Mechanotherapy and Ultrasound Sonopermeation in solid tumors
人胰腺肿瘤和小肠微生物群的分离与鉴定 Awad, D. PDF N/A Isolation and characterization of microbiota from human pancreatic tumors and small intestine
推进白细胞检测:形态学分析的多领域数据集及应对稀疏标注挑战 Rehman, A. PDF N/A Advancing White Blood Cell Detection: A Multi-Domain Dataset for Morphological Analysis and Addressing Sparse Annotation Challenges
SS-31可预防博来霉素诱导的肺损伤和纤维化。 Gu, Q. PDF N/A SS-31 protects against bleomycin-induced lung injury and fibrosis
面向营养不良的综合解决方案:新型即用型治疗食品测试的综合临床前协议 Utume, L. PDF N/A Toward Holistic Solutions to Undernutrition: A Comprehensive Preclinical Protocol for Novel Ready-to-Use Therapeutic Foods Testing
拟南芥生殖阶段莲座叶的年龄依赖性缺铁差异响应 Ngigi, M. PDF N/A Age-dependent differential iron deficiency responses of rosette leaves during reproductive stages in Arabidopsis thaliana
瞬时转录因子耗竭解释了LexA目标启动子对轻度DNA损伤的多样性单细胞响应 Galbusera, L. PDF N/A Transient transcription factor depletions explain diverse single-cell responses of LexA target promoters to mild DNA damage
ST6GAL1介导的肿瘤相关巨噬细胞唾液酸连接转换促进抗炎细胞中携带α2,6-唾液酸化的促癌纳米管形成 Dipta, P. PDF N/A ST6GAL1-mediated sialyl linkage switching in tumor-associated macrophages drives cancer-promoting nanotubes carrying α2,6-sialylation in anti-inflammatory cells
静脉注射猪血浆胞外颗粒对大鼠的可行性——一项急性研究 Chernavsky, N. PDF N/A Feasibility of intravenous injections of pig plasma extracellular particles into rats -- an acute study
结合13C、15N和2H测量海洋浅水海绵的摄食和代谢活动——一项试点研究 Stratmann, T. PDF N/A Combining 13C, 15N, and 2H to measure feeding and metabolic activity in marine, shallow-water sponges - A pilot study
利用多时相和多传感器遥感数据预测林地鸟类物种栖息地 Kuzmich, R. J. PDF N/A Predicting woodland bird species habitat with multi-temporal and multisensor remote sensing data
大规模信息先验以更好地预测稀有树相关微生境的局部发生率 Cottais, P. PDF N/A Large-scale informative priors to better predict the local occurrence rate of a rare tree-related microhabitat
深层土壤微生物群落的功能组成随橡树死亡而变化 Goodman, A. C. PDF N/A Functional composition of deep soil microbial communities changes with oak mortality
在自然啮齿动物种群中,超级传播者具有较低的肠道微生物α多样性以及独特的肠道微生物组成。 Wanelik, K. M. PDF N/A Superspreaders have lower gut microbial alpha-diversity and distinct gut microbial composition in a natural rodent population
由凝聚蛋白和CTCF调控的基因表达统一模型 Choudhary, C. PDF N/A A unified model of gene expression control by cohesin and CTCF
使用空间分子成像技术对固定在福尔马林固定石蜡包埋(FFPE)组织上的整个蛋白质编码人类转录组(18933-plex)进行亚细胞成像 Khafizov, R. PDF N/A Sub-cellular Imaging of the Entire Protein-Coding Human Transcriptome (18933-plex) on FFPE Tissue Using Spatial Molecular Imaging
稳态和刺激下人类骨骼肌细胞代谢性状相关基因调控的功能性解析 Nishino, K. PDF N/A Functional dissection of metabolic trait-associated gene regulation in steady state and stimulated human skeletal muscle cells
在外部机械刺激下,悬浮成纤维细胞片中的力学感应复合物发生动态重塑 Suzuki, M. PDF N/A Dynamic remodeling of mechano-sensing complexes in suspended fibroblast cell-sheets under external mechanical stimulus
gplasCC:从任何细菌物种的短读测序数据中对质粒进行分类和重建 Paganini, J. A. PDF N/A gplasCC: classification and reconstruction of plasmids from short-read sequencing data for any bacterial species
一个强大的通用风险因素差异共表达分析框架 Bass, A. J. PDF N/A A powerful framework for differential co-expression analysis of general risk factors
使用转录组规模上下文扩展单细胞的密集表示 Ho, N. PDF N/A Scaling Dense Representations for Single Cell with Transcriptome-Scale Context
RCVT:一种用于量化系统基因组学中分类群间组成偏倚的新型诊断方法 Steenwyk, J. L. PDF N/A RCVT: a novel diagnostic to quantify compositional biases among taxa for phylogenomics
使用Deconomix在Python中对组学数据进行反卷积——细胞组成、细胞类型特异性基因调控及背景贡献 Altenbuchinger, M. C. PDF N/A Deconvolution of omics data in Python with Deconomix -- cellular compositions, cell-type specific gene regulation, and background contributions
Martini 3力场中优化的蛋白质-辅料相互作用 Prass, T. M. PDF N/A Optimized Protein-Excipient Interactions in theMartini 3 Force Field
银(I)离子与氨基酸侧链之间的精确相互作用:基于12-6 Lennard-Jones势的从底向上参数化方法 Manciocchi, L. PDF N/A Accurate interaction between silver(I) ion and amino acid side chains with the 12-6 Lennard-Jones potential: a bottom-up parameterization approach
DNA错配修复蛋白MSH6是一种PD-L1表达的新型调节因子。 Brooksbank, K. PDF N/A The DNA Mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression
肝细胞癌相关的AXIN1突变驱动Wnt/β-连环蛋白通路活性降低,这种低水平的通路活性使得癌细胞能够在不依赖微环境的情况下生长,并激活YAP/TAZ信号传导。 Venhuizen, A. J. PDF N/A Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling
HIFα异构体特异性活性驱动与VHL相关的肿瘤发生的细胞类型特异性 Lima, J. D. C. C. PDF N/A HIFalpha isoform specific activities drive cell-type specificity of VHL-associated oncogenesis
IKZF2-ERBB4基因融合导致肛门鳞状细胞癌中ERBB4的过度表达,但对ERBB4的抑制并无益处。 RICHON, S. PDF N/A IKZF2-ERBB4 gene fusion leads to ERBB4 overexpression in Anal Squamous Cell Carcinoma but with no benefit for ERBB4 inhibition
microRNA-544a作为关节软骨和骨关节炎中Wnt信号网络的新调节因子 Heluany, C. S. PDF N/A microRNA-544a as a new modulator of the Wnt-signalling network in the articular cartilage and osteoarthritis
Mavacamten促进肌球蛋白头部从开启到关闭的转变,并在松弛的骨骼肌中缩短细丝长度。 Kuehn, M. N. PDF N/A Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed skeletal muscle
性依赖的潜在冷害改变了模型昆虫热耐受性的估计 El-Saadi, M. I. PDF N/A Sex-dependent latent chilling injury changes estimates of thermal tolerance in a model insect
股四头肌运动单元的放电特性及其随收缩水平的变化依赖于膝关节角度 Valencic, T. PDF N/A Motor unit discharge properties of the vastii muscles and their modulation with contraction level depend on the knee-joint angle
针对糖尿病心脏病的靶向糖吞噬ATG8疗法 Mellor, K. M. PDF N/A Targeted glycophagy ATG8 therapy for diabetic heart disease
PlantRing:一种用于解码植物生长、水分关系并创新灌溉技术的高通量可穿戴传感器系统 Sun, T. PDF N/A PlantRing: A high-throughput wearable sensor system for decoding plant growth, water relations and innovating irrigation
一种新的PGRL1旁系同源基因优化了草类光保护的调控,并促进了C4光合作用中的细胞特化。 Nix, S. J. PDF N/A A novel PGRL1 paralog refined the control of photoprotection in grasses and facilitated cell specialisation in C4 photosynthesis
编辑OsPHO1;2的顺式作用元件提高了水稻的磷酸盐转运和产量 Maurya, K. PDF N/A Editing cis-elements of OsPHO1;2 improved phosphate transport and yield in rice
人源间充质基质细胞衍生的线粒体在术后消化道瘘大鼠模型中的治疗潜力:迈向能量纳米生物疗法 Mariani, A. PDF N/A Therapeutic potential of human mesenchymal stromal cell-derived mitochondria in a rat model of post-surgical digestive fistula: towards an energetic nano-biotherapy
爆炸性同步的临近程度决定了神经和经济危机中的网络崩溃和恢复轨迹 Lee, U. PDF N/A Proximity to Explosive Synchronization Determines Network Collapse and Recovery Trajectories in Neural and Economic Crises
通过超解景观构建细胞命运决定的全面图谱 Zhang, X. PDF N/A Constructing a holistic map of cell fate decision by hyper solution landscape
增加的NFAT和NFκB信号传导有助于囊性纤维化患者对烟曲霉感染产生的过度炎症表型。 Bercusson, A. PDF N/A Increased NFAT and NFκB signalling contribute to the hyperinflammatory phenotype in response to Aspergillus fumigatus in cystic fibrosis
追踪癌症免疫治疗中抗原特异性T细胞反应 Shagina, I. A. PDF N/A Tracking antigen-specific T cell response to cancer immunotherapy
金黄色葡萄球菌通过NKG2A介导的天然杀伤细胞免疫调控 Davies, K. PDF N/A NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus
分类学变化对亚马逊棕榈植物区系的影响 Stropp, J. PDF N/A Impacts of taxonomic change on the Amazonian palm flora
选择增强了植物多样性与车前草代谢特征之间的关系 Medina-van Berkum, P. PDF N/A Selection strengthens the relationship between plant diversity and the metabolic profile of Plantago lanceolata
保护鬣蜥多样性:通过陆地环境DNA创新实现非本土鬣蜥的快速低成本追踪 Kuijk, J. PDF N/A Safeguarding Iguana diversity: Enabling rapid and low-effort tracking of non-native iguanas through terrestrial eDNA innovations
利用动物追踪进行大规模中毒事件的早期检测 Curk, T. PDF N/A Using animal tracking for early detection of mass poisoning events
线虫类寄生虫粪类圆线虫是否为犬类动物的动物传染病?——基于群体遗传学的方法。 :iu, Y. PDF N/A Is the nematode Strongyloides stercoralis a zoonosis from dogs? - a population genetics approach.
CGMFinder 从 3H scRNA-seq 数据中识别相关基因模块 Ma, W. PDF N/A CGMFinder Identifies Correlated Gene Modules from 3H scRNA-seq Data
超越运动皮层:对颅内语音神经假体目标位置的脑区评估 Verwoert, M. PDF N/A Moving beyond the motor cortex: a brain-wide evaluation of target locations for intracranial speech neuroprostheses
P4ward:一种用于Protac三元复合物自动建模的平台 Jofily, P. PDF N/A P4ward: an automated modelling platformfor Protac ternary complexes
专家混合模型助力高效且有效的蛋白质理解和设计 Sun, N. PDF N/A Mixture of Experts Enable Efficient and Effective Protein Understanding and Design
Semaglutide类似物增强GLP-1R激活:动态结构与静电学视角 Li, W. PDF N/A Semaglutide Analogues Enhancing GLP-1R Activation: A Dynamic Structural & Electrostatic Perspective
病毒模拟将免疫抑制的结直肠肿瘤微环境重定向为促炎性和CMS1样再生状态 Corry, S. M. PDF N/A Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state
错配修复缺陷对同基因小鼠模型中转移发生的影响 Laplante, P. PDF N/A Effect of MisMatch Repair Deficiency on metastasis occurrence modelized in a syngeneic mouse model
PAG通过与肌动蛋白结合,协调T细胞免疫突触的功能。 Moore, E. K. PDF N/A PAG orchestrates T cell immune synapse function by binding to actin
基于血液组学的系统特异性死亡风险评估模型 Fuentealba, M. PDF N/A Blood Omics Models for System-Specific Mortality Risk Estimation
单细胞转录组学揭示了人类肠道中肥大细胞的异质性 Hussein, H. PDF N/A Single cell transcriptomics reveal mast cell heterogeneity in the human gut
全球生物医学和生物技术重要真菌属曲霉的物种多样性和分布模式 Riedling, O. L. PDF N/A Global patterns of species diversity and distribution in the biomedically and biotechnologically important fungal genus Aspergillus
利用性别依赖的基因表达模式进行精确的混合单细胞RNA测序样本解卷积 Twa, G. M. PDF N/A Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns
利用金刚石中的氮-空位中心探测纳米尺度电化学现象 Fulton, S. PDF N/A Probing Nanoscale Electrochemical Phenomena with Nitrogen-Vacancy Centers inDiamond
柔软的3D打印肌肉超声仿体,具有结构可调的B模式回声强度 Gillespie, S. PDF N/A Soft, 3D printed muscle ultrasound phantom with structurally tunable B-mode echo intensity
使用InMoose进行批量转录组分析,InMoose是Python中的集成多组学开源环境 Colange, M. PDF N/A Bulk Transcriptomic Analysis with InMoose, the Integrated Multi-Omic Open-Source Environment in Python
解开细胞类型和状态转录程序的纠缠 Wang, J. PDF N/A Disentangling cell type and state transcriptional programs
不同条件下观察到的血栓蛋白质组含量:成功预测血栓淀粉样蛋白(原)性的作用 Kell, D. B. PDF N/A The proteome content of blood clots observed under different conditions: successful role in predicting clot amyloid(ogenicity)
芯片上流体诱导的血管重塑:对抗VEGF疗法的启示 Mirzapour-Shafiyi, F. PDF N/A Flow-Induced Vascular Remodeling On-Chip: Implications for Anti-VEGF Therapy
一个数学模型阐明了在增强子-基因预测中使用的ABC评分公式 Nasser, J. PDF N/A A mathematical model clarifies the ABC Score formula used in enhancer-gene prediction
PD-L1表达受微小RNA加工、Wnt/β-catenin信号通路及化疗在Wilms瘤中的调控。 Desai, K. PDF N/A PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
白血病突变蛋白PHF6和PHIP形成一个染色质复合物,抑制髓系白血病干细胞特性。 Pawar, A. S. PDF N/A Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses myeloid leukemia stemness
白血病突变蛋白PHF6和PHIP形成一种染色质复合物,抑制髓系白血病干细胞特性。 Pawar, A. S. PDF N/A Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses myeloid leukemia stemness
β细胞是胰腺导管腺癌发展的关键驱动力 Garcia, C. C. PDF N/A Beta cells are essential drivers of pancreatic ductal adenocarcinoma development
高级别浆液性卵巢癌的单细胞空间图谱揭示了MHC II类分子作为空间肿瘤生态系统和临床结果的关键驱动因素 Perez-Villatoro, F. PDF N/A Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes
知识图谱与机器学习助力神经系统疾病药物研究 Menestrina, L. PDF N/A Knowledge Graph and Machine Learning Help the Research of Drugs Aimed at Neurological Diseases
海湾战争疾病长期影响的表观遗传学研究 Jones, B. C. PDF N/A Epigenetic study of the long-term effects of Gulf War illness
接触钕会减弱胖头鲦鱼(Pimephales promelas)的低氧呼吸反应。 Nykamp, N. M. PDF N/A Exposure to neodymium blunts the hypoxic ventilatory response in fathead minnows (Pimephales promelas)
AtSDR4L及其同源基因在多个种子部位促进种子到幼苗的转变 Lu, B. PDF N/A AtSDR4L and paralog promote seed-to-seedling transition in multiple seed compartments
通过局部润滑修复自身免疫损伤的角膜基质 Efraim, Y. PDF N/A Rebuilding the autoimmune-damaged corneal stroma through topical lubrication
FCRL4和耗竭B细胞特征在肺癌浸润B细胞中 Bryushkova, E. A. PDF N/A FCRL4 and exhausted B cell signature in tumor infiltrating B cells from lung cancer
铬粒素A和卡特斯丁的缺失影响胰腺胰岛稳态、内分泌功能和神经递质 Muntjewerff, E. M. PDF N/A Loss of chromogranin A and catestatin affect pancreatic islet homeostasis, endocrine function, and neurotransmitters
在加拿大北极地区加强数据收集以获取海鸟兼捕信息,结果显示高度变异。 Provencher, J. F. PDF N/A Enhanced data collection in the Canadian Arctic for seabird bycatch information yields highly variable results
药物诱导的癌症持续者的最佳治疗方案涉及释放周期和中间药物剂量。 Corigliano, M. PDF N/A Optimal treatment for drug-induced cancer persisters involves release periods and intermediate drug doses
人类餐后代谢的DNA甲基化和基因表达轨迹 Costeira, R. PDF N/A DNA methylation and gene expression trajectories of human postprandial metabolism
宽频调谐与深部组织光谱检测的磷化铟纳米激光颗粒 Cho, S. PDF N/A Wideband Tuning and Deep-Tissue Spectral Detection of Indium Phosphide Nano-Laser Particles
可微育种:自动微分使得基于梯度的育种策略优化更加高效 Hamazaki, K. PDF N/A Differentiable breeding: Automatic differentiation enables efficient gradient-based optimization of breeding strategies
PqsE在铜绿假单胞菌中作为群体感应转录因子RhlR的适配蛋白发挥作用。 Tchadi, B. V. PDF N/A PqsE acts as an adaptor protein for the quorum-sensing transcription factor RhlR in Pseudomonas aeruginosa
海藻糖支持埃及伊蚊细胞的生长,并调节基因表达和登革病毒复制。 Conway, M. J. PDF N/A Trehalose supports the growth of Aedes aegypti cells and modifies gene expression and dengue virus replication
通过固态核磁共振揭示白色念珠菌和白色念珠菌的细胞壁结构及棘球白素反应 Dickwella Widanage, M. C. PDF N/A Unveiling Cell Wall Structure and Echinocandin Response in Candida auris and Candida albicans via Solid-State NMR
盘基网柄菌-海分枝杆菌感染模型,是一种强大的抗感染化合物高通量筛选平台 Nitschke, J. PDF N/A The Dictyostelium discoideum - Mycobacterium marinum infection model, a powerful high throughput screening platform for anti-infective compounds
康泰唑地对感染脓肿分枝杆菌的小鼠和人类患者不同组织的分布情况 Li, Q. PDF N/A Distribution of contezolid in different tissues of mice and human patients infected with Mycobacterium abscessus
基于TurboID的邻近标记技术发现ABCF2为动物源性病原体多杀性巴氏杆菌的粘附受体 Wang, F. PDF N/A TurboID-based proximity labeling discovers ABCF2 as an adhesion receptor for the zoonotic pathogen Pasteurella multocida
RNA N6-甲基腺苷修饰与猪繁殖与呼吸综合征病毒感染之间的动态相互作用 Tong, J. PDF N/A Dynamic interplay between RNA N6-methyladenosine modification and porcine reproductive and respiratory syndrome virus infection
即使存在沃尔巴克氏菌,蚊子的发育仍需要胞外微生物的参与。 Serrato-Salas, J. PDF N/A Extracellular microbes are required for mosquito development even in the presence of Wolbachia
原噬菌体的诱导有助于在肠道炎症期间改变肠道噬菌体组 Sinha, A. PDF N/A Prophage induction contributes to alterations in the gut phageome during intestinal inflammation
间歇性抑制性泊沙康唑疗法在减轻慢性恰加斯病实验模型中的心脏和消化道病理损害方面无效。 Jayawardhana, S. PDF N/A Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease
基于KP.2的单价mRNA疫苗能够显著增强对SARS-CoV-2的抗体反应。 Wang, Q. PDF N/A KP.2-based monovalent mRNA vaccines robustly boost antibody responses to SARS-CoV-2
通过结合明确的交联信息,改进AlphaFold 3结构建模 Kosinski, J. PDF N/A Improving AlphaFold 3 structural modeling by incorporating explicit crosslinks
利用小鼠嗜性γ-逆转录病毒促进人类淋巴瘤细胞中的基因编辑 Kumar, M. PDF N/A Facilitating Gene Editing in Human Lymphoma Cells Using Murine Ecotropic γ-Retroviruses
ΔNp63β的差异性转录活性由其同工型特异性的C端编码 McCann, A. A. PDF N/A Differential transcriptional activity of ΔNp63β is encoded by an isoform-specific C-terminus
RNAi介导的HBV抗原关闭通过改变T细胞和B细胞的相互作用,增强了PEGIFNalpha的抗病毒免疫效果。 Zai, W. PDF N/A RNAi-mediated HBV antigen shutdown enhances the antiviral immune effects of PEGIFNalpha via altering T and B cell crosstalk
在钴胺素缺乏的条件下,硅藻生产钴胺素下配体,5,6-二甲基苯并咪唑的过程 Gleason, A. K. PDF N/A Production of the cobalamin lower ligand, 5,6-dimethylbenzimidazole, by a diatom under cobalamin-deplete conditions
基于土壤相关氨氧化菌的快速高通量筛选平台,用于生物硝化抑制剂的发现 Kanellopoulos, A. E. PDF N/A A fast-track, high-throughput screening platform for biological nitrification inhibitors discovery based on soil relevant ammonia oxidizing strains
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