| 解密老年听众在噪声环境下的受损语音可懂度：耳蜗突触病变的作用 |
Garrett, M. |
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Deciphering compromised speech-in-noise intelligibility in older listeners: the role of cochlear synaptopathy |
| 惰性原发性皮肤B细胞淋巴瘤类似于持续的抗原反应，没有分化不良的迹象。 |
Griss, J. |
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Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiation |
| 淀粉样蛋白β诱导脂滴介导的阿尔茨海默病中微胶质细胞功能障碍 |
Prakash, P. |
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Amyloid beta Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer's Disease |
| 小鼠皮层培养中微型兴奋性突触后电流的稳态突触可塑性需要神经元Rab3A。 |
Koesters, A. G. |
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Homeostatic Synaptic Plasticity of Miniature Excitatory Postsynaptic Currents in Mouse Cortical Cultures Requires Neuronal Rab3A. |
| DeepCristae是一种用于修复活体显微镜图像中线粒体嵴的卷积神经网络。 |
Papereux, S. |
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DeepCristae, a CNN for the restoration of mitochondria cristae in live microscopy images |
| 视觉工作记忆的稀疏空间支架 |
Liu, B. |
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Sparse spatial scaffolding for visual working memory |
| ZC3H11A突变通过触发PI3K-AKT和NF-κB介导的信号通路，导致人类和小鼠的高度近视。 |
Chen, C. |
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ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB mediated signaling pathway in humans and mice |
| 数据转换和模型选择对微生物组分类数据特征重要性的影响 |
Org, E. |
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Effects of Data Transformation and Model Selection on Feature Importance in Microbiome Classification Data |
| 圈养与野生鼩鼱大脑基因表达的比较揭示了圈养的影响 |
Bedoya Duque, M. A. |
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Gene expression comparisons between captive and wild shrew brains reveal captivity effects |
| 将结核病基因组学引入临床：一个全面的流程，用于从基因组数据预测抗菌药物敏感性，经过ISO标准验证和认证。 |
Horan, K. |
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Bringing TB genomics to the clinic: A comprehensive pipeline to predict antimicrobial susceptibility from genomic data, validated and accredited to ISO standards. |
| 肠道病毒71通过激活储存操纵性钙离子通道和线粒体呼吸作用，对高效病毒复制至关重要。 |
Hsu, B.-Y. |
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Activation of Store-Operated Calcium Entry and Mitochondiral Respiration by Enterovirus 71 Is Essential for Efficient Virus Replication |
| 内体-溶酶体器组装（ELYSA）结构通过哺乳动物卵母细胞到胚胎的转变协调溶酶体降解系统。 |
Satouh, Y. |
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Endosomal-lysosomal organellar assembly (ELYSA) structures coordinate lysosomal degradation systems through mammalian oocyte-to-embryo transition |
| 听觉刺激通过调节阿尔法波段的振荡，延长了视觉整合的时间窗口。 |
Xu, M. |
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Auditory stimuli extend the temporal window of visual integration by modulating alpha-band oscillations |
| 利用机制性序列信息提升蛋白质表达模型的泛化能力 |
Shen, Y. |
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Improving the generalization of protein expression models with mechanistic sequence information |
| 拟南芥对波动光的感知 |
Belmonte, A. |
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Sensory perception of fluctuating light in Arabidopsis |
| Tribus：从多重成像和蛋白质组数据中半自动化发现细胞身份和表型 |
Kang, Z. |
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Tribus: Semi-automated discovery of cell identities and phenotypes from multiplexed imaging and proteomicdata |
| 辅助感觉运动扰动影响已学习的神经表征 |
Rajeswaran, P. |
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Assistive sensory-motor perturbations influence learned neural representations |
| 简单的壳体测量并不能一致地预测龟类的栖息地：对Lichtig和Lucas（2017）的回应 |
Evers, S. W. |
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Simple shell measurements do not consistently predict habitat in turtles: a reply to Lichtig and Lucas (2017) |
| 一种营养依赖型的天蓝色链霉菌觅食表型表现出增强的抗菌活性，并在该属中普遍存在。 |
Soderholm, N. |
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A nutrient-dependent foraging phenotype of S. coelicolor exhibits enhanced antimicrobial activity and is common across the genus |
| SLC13A2转运的柠檬酸是PKM2乙酰化和降解的代谢信号，以抑制肿瘤生长。 |
Xiong, J. |
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SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth |
| COEXIST：协调的单细胞级联多重组织图像整合 |
Heussner, R. T. |
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COEXIST: Coordinated single-cell integration of serial multiplexed tissue images |
| 多种毒素表现出与烟碱型乙酰胆碱受体的共同结合模式 |
Do, H. N. |
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Diverse toxins exhibit a common binding mode to the Nicotinic Acetylcholine Receptors |
| 惊悚的听觉刺激通过加强，而非改变时间，加速了反射性选择伸手任务中的快速视觉运动反应。 |
Weerdesteyn, V. |
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Startling acoustic stimuli hasten reflexive choice reaching tasks by strengthening, but not changing the timing of, express visuomotor responses |
| 聚（烯丙胺）/三聚磷酸盐纳米复合凝聚物作为疫苗开发中依赖NLRP3的系统性佐剂 |
Rizzo, G. P. |
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Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic adjuvant for vaccine development |
| 利用计算机化飞行磨机研究栎树相关郭公甲科（鞘翅目：郭公甲科）飞行性能的种内和种间变异 |
Le Souchu, E. |
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Intra- and interspecific variations in flight performance of oak-associated Agrilinae (Coleoptera: Buprestidae) using computerised flight mills |
| 内感受信号在猕猴的决策过程中产生偏差 |
Cardenas, M. A. |
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Interoceptive Signals Bias Decision Making in Rhesus Macaques |
| 重复的外源性和各向异性机械输入促进极化黏着连接的延长 |
Yang, X. |
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Repeated extrinsic and anisotropic mechanical inputs promote polarized adherens junction elongation |
| 转录组分析揭示了依赖DLK的海马谷氨酸能神经元退化的细胞网络 |
Ritchie, E. M. |
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Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration |
| 膜结合B细胞受体组装的动态与激活 |
Do, H. N. |
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Dynamics and Activation of Membrane-Bound B Cell Receptor Assembly |
| 杜氏肌营养不良症中的肌肉干细胞表现出分子损伤和细胞命运轨迹的改变，影响其再生能力。 |
Granet, J. A. |
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Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity |
| 鞘氨醇-1-磷酸信号通路调控穆勒胶质细胞转变为具有神经发生能力的增殖性前体样细胞的能力 |
Taylor, O. |
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Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells |
| 交联琼脂糖-明胶珠作为研究细菌病原体生物膜的基质 |
Roizman, D. |
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Cross-linked agarose-gelatine beads as a substrate for investigating biofilms of bacterial pathogens |
| 药物性CDK4/6抑制剂促进衰老相关的溶酶体改变，并增强乳腺癌对溶酶体增效剂的敏感性 |
Nehme, J. |
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Pharmacological CDK4/6 inhibitors promote senescence-associated lysosomal alterations and enhance sensitivity to lysosomotropic agents in breast cancer |
| FishPi：一种生物信息学预测工具，用于在斑马鱼中关联piRNA和转座元件 |
Godden, A. M. |
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FishPi: a bioinformatic prediction tool to link piRNA and transposable elements in zebrafish |
| 陆地植物中依赖光的细胞核重新定位的开始 |
Iwabuchi, K. |
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The beginnings of light-dependent nuclear relocation in land plants |
| 片足动物分泌细胞类型与摄食、先天免疫及行为调控相关 |
Mayorova, T. D. |
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Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior |
| 空间多组学与SpaMosaic的马赛克整合 |
Yan, X. |
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Mosaic integration of spatial multi-omics with SpaMosaic |
| STRUCT：一种从原始测序数据中识别RNA二级结构的统计方法，无需进行多序列比对 |
Wang, J. F. |
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STRUCT: a statistical approach to identify RNA secondary structures from raw sequencing data, bypassing multiple sequence alignment |
| 提高生成化学中分子字符串表示的可靠性 |
Reboul, E. |
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Improving the reliability of molecular string representations for generative chemistry |
| 小麦白粉菌效应蛋白与杀伤蛋白UmV-KP4和UmV-KP6结构相关，对真菌具有毒性，并在真菌中定义了扩展的蛋白质家族。 |
de Guillen, K. |
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Zymoseptoria tritici effectors structurally related to killer proteins UmV-KP4 and UmV-KP6 are toxic to fungi, and define extended protein families in fungi |
| 通过同时进行转录起始位点映射和甲基化定量来解码m6Am |
Liu, J. F. |
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Decoding m6Am by simultaneous transcription-start mapping and methylation quantification |
| 感觉运动整合增强了温度刺激处理 |
Anderson, L. S. |
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Sensorimotor integration enhances temperature stimulus processing |
| 通过恢复衰老的骨祖细胞来促进骨修复 |
Reeves, J. |
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Rejuvenating aged osteoprogenitors for bone repair |
| 在曲霉菌感染期间，IFN-STAT1-CYBB轴定义了保护性的浆细胞样DC与中性粒细胞之间的交叉对话。 |
Guo, Y. |
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An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection. |
| 组蛋白乙酰转移酶p300对RORβ的乙酰化以及SIRT1的去乙酰化作用，调控受体的稳定性、周转率及转录活性。 |
O'Leary, T. R. |
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Acetylation of RORβ by histone acetyltransferase p300 and deacetylation by SIRT1 modulates receptor stability, turnover and transcriptional activity. |
| TXNIP通过介导LAT1/SLC7A5的内吞作用，减少进入静止状态的细胞对氨基酸的摄取。 |
Kahlhofer, J. |
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TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence |
| 几何扭曲在陷入棒状突触中减缓了谷氨酸的扩散并塑造了突触反应：来自解剖学上现实的蒙特卡罗模拟的见解 |
Thoreson, W. B. |
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Geometric tortuosity at invaginating rod synapses slows glutamate diffusion and shapes synaptic responses: insights from anatomically realistic Monte Carlo simulations |
| 微生物裂解物作为细胞农业培养基配方中的低成本血清代用品 |
Dolgin, J. |
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Microbial lysates as low-cost serum replacements in cellular agriculture media formulation |
| 岛屿人口结构：哥特兰标志性金雕的繁殖动态及其驱动因素 |
Singh, N. J. |
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Island population demography: Breeding dynamics and drivers of Gotland's iconic Golden Eagles |
| 不同年龄段在噪音环境下的语音感知：蒙古沙鼠与人类的比较研究 |
Jüchter, C. |
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Speech-in-noise perception across the lifespan: A comparative study in Mongolian gerbils and humans |
| 具有自体组织驻留巨噬细胞的人类心脏类器官再现了生理性免疫-心脏相互作用 |
O'Hern, C. |
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Human heart assembloids with autologous tissue-resident macrophages recreate physiological immuno-cardiac interactions |
| 一份关于真实植物来源的胞外囊泡的可靠参考标记物及其系统发育保守程度的纲要 |
Rodriguez de Lope, M. M. |
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N/A |
A compendium of bona fide reference markers for genuine plant-derived extracellular vesicles and their degree of phylogenetic conservation |
| 研究在光系统II中形成TyrD、TyrZ和QA*所引起的Soret区域电致变色带移 |
Boussac, A. |
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Investigation of electrochromic band-shifts in the Soret region induced by the formation of TyrD, TyrZ, and QA*- in Photosystem II |
| 叶酸可预防草原田鼠因发育期接触拟除虫菊酯而导致的自闭症相关表型。 |
Saferin, N. |
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Folate prevents the autism-related phenotype caused by developmental pyrethroid exposure in prairie voles |
| 通过长程连接在皮层区域之间建立动态共识 |
Javadzadeh, M. |
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N/A |
Dynamic consensus-building between neocortical areas via long-range connections |
| 鉴定出一种由SARS-CoV2 S2蛋白衍生、具有超抗原样T细胞刺激特性的肽段 |
Tu, T. H. |
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The identification of a SARs-CoV2 S2 protein-derived peptide with super-antigen-like stimulatory properties on T-cells |
| 遗传性出血性毛细血管扩张症2/Alk1在动脉内皮中的缺失导致鼻出血和脑微出血，伴有异常动脉和缺陷的平滑肌覆盖 |
Zhang, X. |
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Arterial endothelial deletion of hereditary hemorrhagic telangiectasia 2/Alk1 causes epistaxis and cerebral microhemorrhage with aberrant arteries and defective smooth muscle coverage |
| 基因组中转换突变频率高于颠换突变的证据：基于密度泛函理论计算碱基对结合能的结果 |
Deka, N. |
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N/A |
Higher frequency of transition mutation over transversion mutation in genomes: evidence from the binding energy calculation of base pairs using DFT |
| 4-甲基龙胆醇（4-MU）可改善大鼠脑缺血/再灌注损伤后的学习和记忆能力。 |
Tamouk, S. |
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4-Methyllumifrone (4-MU) can improve learning and memory after cerebral ischemia/reperfusion injury in rats |
| 高级肽纳米颗粒能够实现基因编辑器在多种细胞类型中强效且高效的递送。 |
Gustafsson, O. |
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N/A |
Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types |
| 一个评分统治一切：利用GWAS汇总统计数据进行正则化集合多基因风险预测 |
Zhao, Z. |
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N/A |
One score to rule them all: regularized ensemble polygenic risk prediction with GWAS summary statistics |
| 犬持续性苗勒管综合征：对AMH和AMHR2基因组织的新见解 |
Krzeminska, P. |
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Persistent Mullerian duct syndrome in dogs: a new insight into organization of AMH and AMHR2 genes |
| 重塑乳腺癌肝转移局部治疗格局：一种新型瘤内p21靶向经皮疗法提高BALB/c小鼠接种4T1三阴性乳腺癌细胞后的生存率。 |
Margulies, B. S. |
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Reshaping the Landscape of Locoregional Treatments for Breast Cancer Liver Metastases: A novel, intratumoral, p21-targeted percutaneous therapy increases survival in BALB/c mice inoculated with 4T1 triple negative breast cancer cells in the liver. |
| 使用12-6 Lennard-Jones势能模型模拟银(I)离子与蛋白质的相互作用：一种自下而上的参数化方法 |
Manciocchi, L. |
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N/A |
Modelling the interaction between silver(I) ion and proteins with the 12-6 Lennard-Jones potential: a bottom-up parameterization approach |
| 海藻糖促进埃及伊蚊细胞的生长，并调控基因表达和登革病毒复制。 |
Marten, A. D. |
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N/A |
Trehalose supports the growth of Aedes aegypti cells and modifies gene expression and dengue virus replication |
| 通过结合显式的交联信息来改进AlphaFold 3的结构建模 |
Kosinski, J. |
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Improving AlphaFold 3 structural modeling by incorporating explicit crosslinks |
| 在专科神经精神病诊所中，血浆pTau181水平升高与阿片类药物使用相关，并在临床相关的时间尺度上指导药物剂量调整。 |
Hanson, E. |
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Elevated plasma pTau181 in a specialty neuropsychiatric clinic is associated with opioid use and guides medication titration on a clinically relevant short-time scale |
| 呼吸阶段调节与视觉刺激相关的任务神经表征 |
Stetza, L. |
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N/A |
The respiratory phase modulates task-related neural representations of visual stimuli |
| 超越刺激起始：在自由观看过程中，物体内的持续注视不会重新唤起类别表征。 |
Auerbach-Asch, C. R. |
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N/A |
Beyond stimulus onset: Ongoing fixations within an object do not re-evoke category representations during free-viewing. |
| 情感内容影响视觉工作记忆的精确度 |
Haghian, Z. |
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N/A |
Emotional content effects the precision of visual working memory |
| 用于果蝇活体内单细胞标记和操控的稀疏驱动系统 |
Xu, C. |
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N/A |
The sparse driver system for in vivo single-cell labeling and manipulation in Drosophila |
| 颞叶癫痫主要表现为区域特异性的发作间期皮层抑制 |
Kienitz, R. |
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N/A |
Temporal Lobe Epilepsy is dominated by Region Specific Interictal Cortical Inhibition |
| 在韩国，小刺猬（Crocidura lasiura）中检测并描述了琅琊病毒 |
Natasha, A. |
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N/A |
Detection and characterization of Langya virus in Crocidura lasiura, Republic of Korea |
| 在韩国，检测并鉴定出朗格雅病毒存在于灰麝鼩（Crocidura lasiura）中。 |
Natasha, A. |
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N/A |
Detection and characterization of Langya virus in Crocidura lasiura, Republic of Korea |
| 逆转录转座子LINE1的反式调控分化过程维持胚胎干细胞特性 |
Ren, L. |
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N/A |
Retrotransposon LINE1 trans-regulatory differentiation process maintain embryonic stem cell identity |
| 人类细胞中基因低表达和高表达的形态图 |
Chandrasekaran, S. N. |
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N/A |
Morphological map of under- and over-expression of genes in human cells |
| NJGPT：一种由大型语言模型驱动、用户友好的系统发育树构建解决方案 |
Wang, Z. |
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N/A |
NJGPT: A Large Language Model-Driven, User-Friendly Solution for Phylogenetic Tree Construction |
| 通过微喷雾器的通道增加功能活性——对时间分辨冷冻电镜活性测定的影响 |
Garg, P. |
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N/A |
Passage through micro-sprayer increases functional activity-implications for activity assays in time-resolved cryo-EM |
| 缺氧诱导因子驱动透明细胞肾癌中miRNA介导的L2HGDH和HIF1A下调，与14q缺失无关 |
Seal, S. |
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Hypoxia inducible factors drive miRNA-mediated downregulation of L2HGDH and HIF1A in clear cell renal cancer independent of 14q deletion |
| 时间配置作为声音的新特征：心理和神经生理学证据，跨物种一致性及潜在的神经机制 |
Zhai, Y. |
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N/A |
Temporal Configuration as a New Feature of Sound: Psychological and Neurophysiological Evidence, Cross-species Consistency and Underlying Neuronal Mechanisms |
| 强迫性倾向个体在概率学习及更新预测表征中的个体差异 |
Brezoczki, B. |
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N/A |
Individual differences in probabilistic learning and updating predictive representations in individuals with obsessive-compulsive tendencies |
| 中国女性阴道微生态与炎症的关系研究。 |
Zhang, Y. |
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N/A |
Vaginal Microbiome and Inflammation Among Chinese Women. |
| Tabula Sapiens揭示了28种人体器官和组织中细胞类型的转录因子表达、衰老效应和性别特异性特征。 |
The Tabula Sapiens Consortium, |
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N/A |
Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues |
| 在诱导多能干细胞衍生的疾病模型中扩展GABA能神经元的多样性 |
Hu, R. |
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N/A |
Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models |
| 从微观到宏观：鸟类染色体进化主要受自然选择驱动 |
Alfieri, J. M. |
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N/A |
From Micro to Macro: Avian Chromosome Evolution is Dominated by Natural Selection |
| 在听觉处理动物模型中描述早期生活压力的行为效应 |
Hardy, K. A. |
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N/A |
Characterizing Behavioral Effects of Early-Life Stress in an Animal Model of Auditory Processing |
| 普遍的言语节奏规律：语调单元形成低频节奏，并平衡跨语言的音节率变异性。 |
Inbar, M. |
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N/A |
A universal of speech timing: Intonation units form low frequency rhythms and balance cross-linguistic syllable rate variability |
| 平等群体中的社会补丁觅食理论 |
Blum Moyse, L. |
PDF |
N/A |
Social patch foraging theory in an egalitarian group |
| 基于基因共表达网络的间充质干细胞分析揭示了异位骨化的关键基因和分子通路 |
Yang, M. |
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N/A |
A gene co-expression network-based analysis of mesenchymal stromal cells reveals novel genes and molecular pathways underlying heterotopic ossification |
| 在津巴布韦利用替代传粉者提高生物多样性和小农户收入 |
Allebone-Webb, S. |
PDF |
N/A |
Farming with Alternative Pollinators for Increased Biodiversity and Smallholder Incomes in Zimbabwe |
| 最佳实践质量光度法：单分子质量测量的优化指南 |
Kratochvil, J. |
PDF |
N/A |
Best practice mass photometry: A guide to optimal single molecule mass measurement |
| 植物对特定环境条件的电生理反应 |
Wilkening, S. H. P. |
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N/A |
Plant electrophysiological reactions to specific environmental conditions |
| 组蛋白H3.3中单个氨基酸突变揭示了H3K4甲基化在植物中的功能意义 |
Xue, M. |
PDF |
N/A |
Single amino acid mutations in histone H3.3 illuminate the functional significance of H3K4 methylation in plants |
| 比较早熟、高产及育种潜力方面的籽粒类型和菜用大豆性状 |
Saha, M. |
PDF |
N/A |
Comparing grain type and vegetable soybean traits for early maturity, higher yield, and breeding potential |
| 比较谷物类型和蔬菜大豆的早熟性、高产性和育种潜力 |
Saha, M. |
PDF |
N/A |
Comparing grain type and vegetable soybean traits for early maturity, higher yield, and breeding potential |
| 面向AI抗干扰的核酸合成订单筛查：流程、结果与建议 |
Wittmann, B. J. |
PDF |
N/A |
Toward AI-Resilient Screening of Nucleic Acid Synthesis Orders: Process, Results, and Recommendations |
| 使用tACS对α和β频率神经节律进行研究，探讨其对相位对齐的TMS诱发的皮层脊髓兴奋性的影响 |
Gialopsou, A. |
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N/A |
An investigation of the effects of α and β-frequency neural entrainment using tACS on phase-aligned TMS-evoked corticospinal excitability |
| Anapc5和Anapc7作为KIF18A功能在生育力和有丝分裂进程中的遗传修饰因子 |
Nesbit, C. |
PDF |
N/A |
Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression |
| 探索线粒体-核相互作用在调控细胞生理中的作用：来自种间细胞质杂种的启示 |
Gaertner, K. |
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N/A |
Exploring mitonuclear interactions in the regulation of cell physiology: insights from interspecies cybrids |
| 小胶质细胞经历趋化因子受体CX3CR1介导的胞外Tau内吞作用。 |
Chidambaram, H. |
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N/A |
Microglia undergoes chemokine receptor, CX3CR1-mediated internalization of extracellular Tau |
| 溶酶体功能、应激抵抗和修复受损是由于表达亚历山大病GFAP R239C突变体所致。 |
Hernandez-Gerez, E. |
PDF |
N/A |
Lysosomal function, resistance to stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant |
| 通过E3连接酶TRIM21诱导的化学介导的核孔复合体蛋白降解 |
LI, X. |
PDF |
N/A |
Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21 |
| PHLPP2是一种假磷酸酶，在多细胞生物的祖先中失去了活性。 |
Husremovic, T. |
PDF |
N/A |
PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor |
| PHLPP2是一种假磷酸酶，在多细胞生物的祖先中失去了活性。 |
Husremovic, T. |
PDF |
N/A |
PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor |
| Pirin 不与 p65 结合，也不调节 NFκB 依赖的基因表达。 |
Meschkewitz, M. |
PDF |
N/A |
Pirin does not bind to p65 or regulate NFkappaB-dependent gene expression |
| mRNArchitect：mRNA序列的优化设计 |
Budzinska, M. A. |
PDF |
N/A |
mRNArchitect: optimized design of mRNA sequences |
| 力场参数、实验测量与分子动力学模拟的综合数据库 |
Banas, P. |
PDF |
N/A |
Integrated Database of Force-Field Parameters, Experimental Measurements and Molecular Dynamics Simulations |
| 一种计算进化发育生物学方法，用于阐明PLETHORA转录因子在调控根系发育中的作用 |
Rodriguez-Herrera, J. |
PDF |
N/A |
A computational Evo-Devo approach for elucidating the roles of PLETHORA transcription factors in regulating root development |
| MpANT-生长素环调节地钱发育 |
Dipp-Alvarez, M. |
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N/A |
The MpANT-auxin loop modulates Marchantia polymorpha development |
| 组蛋白H2A及其变体H2A.Z和H2A.W在拟南芥中的结构与功能相互关系 |
Wang, Y. |
PDF |
N/A |
Structural and functional interrelationship of histone H2A and its variants H2A.Z and H2A.W in Arabidopsis |
| 在拟南芥中，细胞质中的光呼吸乙醛酸旁路在高光条件下支持光合作用和植物生长。 |
Jiang, X. |
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N/A |
A photorespiratory glyoxylate shunt in the cytosol supports photosynthesis and plant growth under high light conditions in Arabidopsis |
| 驯化是否以牺牲耐压性为代价来促进叶片生长？对八个早熟禾亚科草种的证据进行搜索 |
Yun, J. |
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N/A |
Does domestication trade-off stress tolerance for leaf growth? A search for evidence across eight Pooideae grass species |
| 一种与RdDM相关的雌性特异性元件指导水稻配子体发育过程中的从头DNA甲基化 |
Kim, T. |
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N/A |
A female-specific RdDM-associated element guides de novo DNA methylation during rice gametophyte development |
| 分泌途径运输维持拟南芥减数分裂期间纺锤体分离的细胞器带 |
JIANG, H. |
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N/A |
Secretory trafficking maintains the organelle band for spindle separation during Arabidopsis meiosis |
| 分泌运输在拟南芥减数分裂期间维持着丝粒分离的细胞器带。 |
Piskorz, E. W. |
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N/A |
Secretory trafficking maintains the organelle band for spindle separation during Arabidopsis meiosis |
| 多核巨细胞是卵巢衰老的标志，具有独特的免疫和降解相关分子特征。 |
Converse, A. |
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N/A |
Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures |
| 多核巨细胞是卵巢衰老的标志，具有独特的免疫和降解相关分子特征。 |
Converse, A. |
PDF |
N/A |
Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures |
| Tmbim5 缺失导致斑马鱼肌肉萎缩，但不会加剧 mcu 或 slc8b1 敲除的表型 |
Wasilewska, I. |
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N/A |
Tmbim5 loss causes muscle atrophy in zebrafish without exacerbating mcu or slc8b1 knockout phenotypes |
| 通过高内涵成像在人类破骨细胞中鉴定抗吸收GPCR |
Price, M. L. |
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N/A |
Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts |
| 利用集成明场和荧光显微镜的组织学引导单细胞质谱成像 |
Potthoff, A. |
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N/A |
Histology-Guided Single-Cell Mass Spectrometry Imaging using Integrated Bright-field and Fluorescence Microscopy |
| 利用分离信息进行变异过滤可提高向日葵（Helianthus annuus L.）花蜜生产基因的定位 |
Barstow, A. C. |
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N/A |
Variant filters using segregation information improve mapping of nectar-production genes in sunflower (Helianthus annuus L.) |
| 常见的菌根网络介导的植物间信号能够调节植物对生物胁迫的响应以及对叶部病原体的防御 |
Orlovskis, Z. |
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N/A |
Common mycelial network mediated inter-plant signals modulate plant biotic stress responses and defence against foliar pathogens |
| 指纹图谱和化学型分析方法揭示了野生啤酒花（Humulus lupulus L.）之间广泛的遗传和代谢多样性。 |
Ducrocq, F. |
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N/A |
Fingerprinting and chemotyping approaches reveal a wide genetic and metabolic diversity among wild hops (Humulus lupulus L.) |
| 一种综合方法用于分析蝙蝠对人类病原体的抗体反应 |
Toshkova, N. |
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N/A |
An integrative approach for profiling antibody responses in bats to human pathogens |
| 纤毛门锥虫属布鲁氏锥虫中Sec13同源基因的多功能作用 |
Sharif, M. |
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N/A |
Multifunctional Roles of Sec13 Paralogues in the Euglenozoan Trypanosoma brucei |
| α-突触核蛋白纤维的结构多态性改变了Hsc70介导的解聚途径 |
Jager, S. |
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N/A |
Structural polymorphism of alpha-synuclein fibrils alters pathway of Hsc70 mediated disaggregation |
| α-突触核蛋白纤维的结构多态性改变了Hsc70介导的解聚途径 |
Jager, S. |
PDF |
N/A |
Structural polymorphism of alpha-synuclein fibrils alters pathway of Hsc70 mediated disaggregation |
| α-突触核蛋白纤维的结构多态性改变了Hsc70介导的解聚途径 |
Jaeger, S. |
PDF |
N/A |
Structural polymorphism of alpha-synuclein fibrils alters pathway of Hsc70 mediated disaggregation |
| 基于CBAM-ResNet34的温室草莓发育过程分类与评估方法 |
Wang, J. |
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N/A |
CBAM-ResNet34-based classification and evaluation method for developmental processes of greenhouse strawberries |
| 霉菌生长和户外暴露对肯尼亚西部诱人目标糖饵效力的影响。 |
Yalla, n. O. |
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N/A |
Influence of mould growth and outdoor exposure on the efficacy of attractive targeted sugar baits in western kenya. |
| 短暂光刺激小鼠手部引发的皮层动力学：手/前肢S1和M1区的反应 |
Pina Novo, D. |
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N/A |
Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouses hand |
| Galectin-9与树突状细胞中的HLA-DR结合，调控免疫突触的形成和T细胞的增殖。 |
Rodgers Furones, A. |
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N/A |
Galectin-9 binding to HLA-DR in dendritic cells controls immune synapse formation and T cell proliferation |
| 疫苗接种和感染会引发两种不同的人类长期记忆B细胞群体。 |
Perugino, C. |
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N/A |
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection |
| 哺乳动物的SKI复合体是一种广谱抗病毒药物靶点，它通过上调细胞胆固醇水平来抑制病毒复制。 |
Weston, S. |
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N/A |
The mammalian SKI complex is a broad-spectrum antiviral drug target that upregulates cellular cholesterol to inhibit viral replication |
| 解析毛癣菌属（Trichophyton mentagrophytes）复合体内的系统发育关系：基于RADseq基因组的方法对“特比萘芬耐药”的Trichophyton indotineae作为独立物种的地位提出质疑 |
Svarcova, M. |
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N/A |
Resolving phylogenetic relationships within the Trichophyton mentagrophytes complex: a RADseq genomic approach challenges status of "terbinafine-resistant" Trichophyton indotineae as distinct species |
| 硫磺岛高二氧化碳海洋环境中珊瑚礁共生体群落的变迁 |
Huerlimann, R. |
PDF |
N/A |
Shifts in Coral Reef Holobiont Communities in the High-CO2 Marine Environment of Iotorishima Island |
| 睫状体尖端中心粒的结构揭示了微管接缝结合蛋白SPEF1的独特作用 |
Legal, T. |
PDF |
N/A |
Structure of the ciliary tip central pair reveals the unique role of the microtubule-seam binding protein SPEF1 |
| VEXAS贫血是一种镶嵌性红细胞生成减少症。 |
Rodrigues, F. |
PDF |
N/A |
VEXAS anemia is a mosaic erythroblastopenia |
| 面向光谱变异分析：非目标方法的数据质量框架 |
Nichani, K. |
PDF |
N/A |
Towards Spectral Variation Analysis: A Data Quality Framework for Non-Targeted Methods |
| 对来自异质性患者来源的GBM干细胞模型进行全面的药理学调查 |
Elliott, R. J. |
PDF |
N/A |
A comprehensive pharmacological survey across heterogeneous patient-derived GBM stem cell models |
| 依赖于己糖激酶1的植物非生物胁迫免疫取决于叶绿体定位 |
Bagshaw, S. B. |
PDF |
N/A |
Hexokinase 1-mediated plant immunity under abiotic stress depends on chloroplast positioning |
| CrGEF1、CrGAP1 和 CrGDI2 作为调节 ROP-GTPase 介导的长春花中生物碱生物合成调控的关键因子。 |
Sharma, A. |
PDF |
N/A |
CrGEF1, CrGAP1, and CrGDI2 function as key regulators of ROP-GTPase mediated modulation of alkaloid biosynthesis in Catharanthus roseus |
| 产品中立性功能定义的基因相互作用源于细胞生长机制模型。 |
Fuentes Valenzuela, L. |
PDF |
N/A |
The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth |
| ALDH3A1介导的活性醛类解毒作用对去神经化与肌萎缩侧索硬化症进展中的不同肌肉反应有贡献 |
Li, A. |
PDF |
N/A |
ALDH3A1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to denervation and Amyotrophic Lateral Sclerosis progression |
| 跨越上皮-间质转化（EMT）景观的过渡路径受网络逻辑支配。 |
Dey, A. |
PDF |
N/A |
Transition paths across the EMT landscape are dictated by network logic |
| 语言网络揭示了由基于域的单词组成的蛋白质句子的语法约束 |
Shimpi, A. A. |
PDF |
N/A |
Linguistic networks uncover grammatical constraints of protein sentences comprised by domain-based words |
| 受调控的资源再分配在酵母应激反应中是转录上硬连线的 |
Kocik, R. A. |
PDF |
N/A |
Regulated resource reallocation is transcriptionally hard wired into the yeast stress response |
| 使用单细胞和空间转录组学数据识别替代多聚腺苷酸化工具的指南 |
Zhao, Q. |
PDF |
N/A |
Guidelines for alternative polyadenylation identification tools using single-cell and spatial transcriptomics data |
| 诱导B细胞受体多样性预测PD-1阻断免疫疗法反应。 |
Che, Y. |
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N/A |
Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response. |
| 小热休克蛋白1（HSPB1）的协同进化受到α-晶体蛋白结构域与无序区域之间相互作用的促进 |
Racigh, V. |
PDF |
N/A |
Coevolution in Small Heat Shock Protein 1 (HSPB1) is Promoted by Interactions between the Alpha-Crystallin Domain and the Disordered Regions |
| 双功能变二烯合酶的结构提供了对生物合成二萜装配和环化机制的独特见解。 |
Wenger, E. S. |
PDF |
N/A |
Structure of Bifunctional Variediene Synthase Yields Unique Insight on Biosynthetic Diterpene Assembly and Cyclization |
| 绘制人类蛋白质组中隐秘磷酸化位点的图谱 |
Gasparotto, D. |
PDF |
N/A |
Mapping Cryptic Phosphorylation Sites in the Human Proteome |
| 变异刺突蛋白动力学驱动SARS-CoV-2的免疫逃逸 |
Ugurlu, H. |
PDF |
N/A |
Altered spike dynamics drives immune evasion of SARS-CoV-2 |
| 实验性猴痘病毒感染在大鼠中的研究 |
Rockx, B. |
PDF |
N/A |
Experimental monkeypox virus infection in rats |
| 施马伦贝格病毒的非结构蛋白NSs和NSm对于库蠓属的索诺兰库蠓进行实验性感染并非必需。 |
Wernike, K. |
PDF |
N/A |
Schmallenberg virus non-structural proteins NSs and NSm are not essential for experimental infection of Culicoides sonorensis biting midges |
| 在C3HeB/FeJ小鼠的隐性新型隐球菌感染过程中，肺部肉芽肿的形成经历了三个免疫学阶段。 |
Betancourt, J. J. |
PDF |
N/A |
Pulmonary granuloma formation during latent Cryptococcus neoformans infection in C3HeB/FeJ mice involves progression through three immunological phases |
| 在缺乏亲缘识别的情况下，嵌合体的聚集多细胞性 |
Weltzer, M. L. |
PDF |
N/A |
Chimeric aggregative multicellularity in absence of kin discrimination |
| HIV-1单个转录起始位点突变体展现出互补的复制功能，这些功能可以通过回复突变得以恢复。 |
GC, K. |
PDF |
N/A |
HIV-1 single transcription start site mutants display complementary replication functions that are restored by reversion |
| 一种鉴定新生隐球菌敲除文库保真性的方法 |
Jacobs, E. |
PDF |
N/A |
A method for authenticating the fidelity of Cryptococcus neoformans knockout collections |
| 一种新型白色念珠菌蛋白，受交配信号通路调控，塑造了物种间相互作用 |
Parnandi, V. A. |
PDF |
N/A |
A novel Candida glabrata protein regulated by mating signaling pathway shapes inter-species interaction |
| 结核分枝杆菌痰液直接测序的方案和产率：系统综述与荟萃分析 |
Mann, B. C. |
PDF |
N/A |
Systematic review and meta-analysis of protocols and yield of direct from sputum sequencing of Mycobacterium tuberculosis |
| 深度突变扫描（DMS）的CHIKV E3/E2病毒库映射了病毒氨基酸偏好，并预测了中和CHIKV抗体的病毒逃逸突变体。 |
Stumpf, M. M. |
PDF |
N/A |
Deep mutationally scanned (DMS) CHIKV E3/E2 virus library maps viral amino acid preferences and predicts viral escape mutants of neutralizing CHIKV antibodies |
| 乌苏图病毒非洲3.1系，葡萄牙，2021-2023年 |
Queiros, J. |
PDF |
N/A |
Usutu virus African 3.1 lineage, Portugal, 2021-2023 |
| 在复制压力的进出之间：基于PCNA/RPA1的动态调控同一细胞中的复制叉停滞与重启 |
Dyankova-Danovska, T. K. |
PDF |
N/A |
In and out of replication stress: PCNA/RPA1-based dynamics of fork stalling and restart in the same cell |
| 高分辨率成像与三维视网膜色素上皮层结构解析 |
Donaldson, K. J. |
PDF |
N/A |
High resolution imaging and interpretation of three-dimensional RPE sheet structure |
| PTX3调控成纤维细胞-上皮细胞动力学在肺损伤与修复中的作用 |
Bammert, M.-T. |
PDF |
N/A |
PTX3 Governs Fibroblast-Epithelial Dynamics in Lung Injury and Repair |
| 高通量发现与深入表征细胞周期蛋白-CDK结合基序 |
Ord, M. |
PDF |
N/A |
High-throughput discovery and deep characterization of cyclin-CDK docking motifs |
| PTTG1介导的周细胞功能障碍驱动糖尿病诱导的微血管功能障碍 |
Zhang, L. |
PDF |
N/A |
PTTG1-Mediated Pericyte Dysfunction Drives Diabetes-Induced Microvascular Dysfunction |
| 在疫情期间，SARS-CoV-2基因组组成异质性呈现出加速下降的系统发育趋势。 |
Oliver, J. L. |
PDF |
N/A |
An accelerating, decreasing phylogenetic trend in SARS-CoV-2 genome compositional heterogeneity during the pandemic |
| 杂交和基因流对基因共表达网络的影响 |
Runghen, R. |
PDF |
N/A |
Effects of hybridization and gene flow on gene co-expression networks |
| 广泛存在的基因-环境相互作用塑造了住院COVID-19患者对SARS-CoV-2感染的免疫反应 |
Randolph, H. E. |
PDF |
N/A |
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients |
| 癌基因SLC35F2是一种对微量营养素喹啉和喹喔啉具有高特异性的转运体。 |
Burtnyak, L. |
PDF |
N/A |
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine |
| 鉴定针对淋病奈瑟菌丝氨酸乙酰转移酶的新型抑制剂 |
Oldham, K. |
PDF |
N/A |
Identification of novel inhibitors targeting serine acetyltransferase from Neisseria gonorrhoeae |
| SMYD2-PARP1复合物的结构揭示了肽结合的生产性和变构性模式 |
Zhang, Y. |
PDF |
N/A |
Structure of the SMYD2-PARP1 Complex Reveals Both Productive and Allosteric Modes of Peptide Binding |
| 基于瓶子的深度单细胞蛋白质组学一步预处理及其在卵母细胞老化中的应用 |
Yang, Y. |
PDF |
N/A |
Simple One-step Vial-based Pretreatment for Deep Single-cell Proteomics and Its Application to Oocyte Aging |
| 利用FBXW7体细胞突变型R465C进行靶向蛋白质降解 |
Basu, A. A. |
PDF |
N/A |
Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation |
| 进化对位置序列、集体性质和原弹性蛋白序列风格施加了限制，这些限制是由形成和功能的基本要求所决定的，这些要求与细胞外弹性基质的形成和功能密切相关。 |
Keeley, F. W. |
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N/A |
Evolutionary Constraints on Positional Sequence, Collective Properties and Sequence Style of Tropoelastin Dictated by Fundamental Requirements for Formation and Function of the Extracellular Elastic Matrix |
| tilvestamab与AXL复合物的结构分析 |
Christakou, E. |
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N/A |
Structural analysis of tilvestamab in complex with AXL |
| 结核分枝杆菌感染的肺泡上皮细胞中的同位素示踪表明，其代谢特异性与其毒力和耐药状态相关。 |
Akram, S. |
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Isotopic tracing in Mycobacterium tuberculosis-infected alveolar epithelial cells indicates metabolic specificity to their virulence and drug-resistance status |
| 通过计算机预测域插入位点实现蛋白质别构开关的合理工程设计 |
Wolf, B. |
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N/A |
Rational engineering of allosteric protein switches by in silico prediction of domain insertion sites |
| BEVA2.0：利用黄金门兼容向量进行模块化组装，扩展遗传工程应用 |
Geddes, B. A. |
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N/A |
BEVA2.0: Modular Assembly of Golden Gate-Compatible Vectors with Expanded Utility for Genetic Engineering |
| HIV-1蛋白编码序列存在于相关细菌中。 |
Pelaez-Prestel, H. F. |
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N/A |
HIV-1 protein coding sequences are present in relevant bacteria |
| 一种主要的昆虫寄生虫通过干扰白纹伊蚊传播基孔肯雅病毒。 |
Martin, E. |
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A major entomoparasite interferes with Chikungunya transmission by Aedes albopictus |
| 隐形眼镜佩戴改变了角膜上皮和细菌对铜绿假单胞菌的转录反应 |
Kumar, N. G. |
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N/A |
Contact Lens Wear Alters Transcriptional Responses to Pseudomonas aeruginosa in Both the Corneal Epithelium and the Bacteria |
| 在奶牛场中，与临床相关的稳定蝇和粪便来源的细菌分离物中，抗菌药物抗性表型和基因的流行情况 |
Sommer, A. J. |
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Prevalence of antimicrobial resistance phenotypes and genes in stable fly- and manure-derived bacterial isolates from clinically relevant taxa in dairy settings |
| 血小板生物能量学与C57BL/6J小鼠骨骼肌代谢相关 |
Wilkinson, M. S. |
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Platelet bioenergetics correlate with skeletal muscle metabolism in C57BL/6J mice |
| RNA结合蛋白PRRC2B在饥饿期间保护5' TOP mRNA，以在营养恢复期间维持核糖体生物合成。 |
Goldberg, N. |
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The RNA-binding protein PRRC2B preserves 5' TOP mRNA during starvation to maintain ribosome biogenesis during nutrient recovery |
| 细胞原型图谱 |
Crowley, G. |
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N/A |
An Atlas of Cellular Archetypes |
| 扩展HP1a结合的共识序列和异染色质组装的分子语法 |
Colmenares, S. U. |
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N/A |
Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly |
| D1是一种新型增强子阻断蛋白，其功能通过多个富含AT的简单序列重复实现。 |
Kundurthi, P. |
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D1 is a novel enhancer blocker protein that functions via multiple AT-rich simple sequence repeats |
| 谱系特异性氨基酸定义了Rad51和Dmc1重组酶单体-单体界面的功能属性 |
Petassi, M. |
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Lineage-specific amino acids define functional attributes of the protomer-protomer interfaces for the Rad51 and Dmc1 recombinases |
| CRISPR/AAV介导的精确基因组编辑在心脏应用 |
Zheng, Y. |
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N/A |
Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing |
| 皮肤元转录组学揭示了微生物活动和基因表达在整个人体中的变异景观 |
Chia, M. |
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N/A |
Skin metatranscriptomics reveals landscape of variation in microbial activity and gene expression across the human body |
| PITHD1：细胞休眠期间26S蛋白酶体的内源性抑制剂 |
Amann, S. J. |
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PITHD1: An Endogenous Inhibitor of the 26S Proteasome During Cellular Dormancy |
| 多组学分析苜蓿和小麦诱发西藏绵羊瘤胃胀气的机制 |
Zhao, W. |
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Multi-omics analysis of the mechanism of alfalfa and wheat-induced rumen flatulence in Xizang sheep |
| 色素上皮衍生因子缺失使C57BL/6J小鼠对光诱导的视网膜损伤敏感 |
Shelton, D. A. |
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N/A |
Loss of Pigment Epithelium Derived Factor Sensitizes C57BL/6J Mice to Light-Induced Retinal Damage |
| 一种预测单细胞蛋白质组学特性的算法 |
Arroyo, J. I. |
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N/A |
An algorithm for predicting per-cell proteomic properties |
| 掌握曼努之技 - 人类如何制造巨大水花 |
Rohilla, P. |
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N/A |
Mastering the Manu - How humans create large splashes |
| 口服烟酰胺核糖补充剂在DBA/2J小鼠模型中保护视网膜神经节细胞 |
Zhang, N. |
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Oral supplementation with Nicotinamide Riboside treatment protects RGCs in DBA/2J mouse model |
| 由植物乳杆菌SJ33产生的新型低分子量化合物对肺炎克雷伯菌的抗生物膜活性 |
Ray Mohapatra, A. |
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Anti-biofilm activity of new low molecular weight compounds produced by Lactiplantibacillus plantarum SJ33 against Klebsiella pneumoniae |
| 人类干细胞衍生的GABA能中间神经元发育揭示了早期亚型多样性的出现，随后是逐渐的电化学成熟过程。 |
Bershteyn, M. |
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Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity followed by gradual electrochemical maturation |
| 揭示人类大脑活动中的节奏分类 |
Barbero, F. M. |
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Revealing rhythm categorization in human brain activity |
| 自恋型和反社会型人格特质均编码于三重网络中：连接组学证据 |
Jornkokgoud, K. |
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Narcissistic and Antisocial Personality Traits are both encoded in the Triple Network: Connectomics evidence |
| 单细胞全长异构体测序揭示了在脑皮质发育过程中自闭症谱系障碍的转录失调 |
Xu, X. |
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Single-Cell full-length Isoform Sequencing Unveils Transcriptional Dysregulation in Autism Spectrum Disorder During Cerebral Cortex Development |
| 在羊膜动物中，半球间形态发生的保守性先于胼胝体（corpus callosum）的进化。 |
Noji, R. |
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Conserved interhemispheric morphogenesis in amniotes preceded the evolution of the corpus callosum |
| 组蛋白去甲基化酶KDM5在大脑中具有绝缘活性 |
Yheskel, M. |
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The histone demethylase KDM5 has insulator activity in the brain |
| 鸟类端脑和小脑的体积可以通过数字脑内模准确估算。 |
Keirnan, A. R. |
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Avian telencephalon and cerebellum volumes can be accurately estimated from digital brain endocasts |
| 背内侧纹状体的胆碱能中间神经元介导雄性小鼠社交层级动态中的胜者-败者效应。 |
Hsu, M.-T. |
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Cholinergic interneurons of the dorsomedial striatum mediate winner-loser effects on social hierarchy dynamics in male mice. |
| 在脑发育过程中，小胶质细胞中的组织蛋白酶B促进神经元的吞噬作用。 |
Silva, N. J. |
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Microglial cathepsin B promotes neuronal efferocytosis during brain development |
| 早期生活压力会损害活体前额叶-杏仁核网络内功能性相互作用和神经活动的发育 |
Donati, A. |
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Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo |