| 模拟西欧的欧亚猞猁种群：未来50年的前景如何？ |
Bauduin, s. |
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N/A |
Modelling Eurasian lynx populations in Western Europe: What prospects for the next 50 years? |
| 利用Fisher核方法从脑动力学模型中准确可靠地预测个体特征 |
Ahrends, C. |
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N/A |
Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel |
| Heron：一个直观的知识图谱编辑器，用于实现基于Python的实验流程。 |
Dimitriadis, G. |
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N/A |
Heron: A Knowledge Graph editor for intuitive implementation of python based experimental pipelines. |
| 作为肺结核的辅助治疗药物——去铁胺 |
Kaushik, S. R. |
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N/A |
Deferoxamine as adjunct therapeutics for tuberculosis |
| 产生相同M矩阵的替代突变架构可能导致不同的进化分歧模式 |
Jiang, D. |
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N/A |
Alternative mutational architectures producing identical M-matrices can lead to different patterns of evolutionary divergence |
| 异质性突触稳态：一种提升皮层信息传播的新机制 |
Razi, F. |
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N/A |
Heterogeneous Synaptic Homeostasis: A Novel Mechanism Boosting Information Propagation in the Cortex |
| 转座子活性在全基因组复制后塑造顺式调控元件进化中的作用 |
Monsen, O. |
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N/A |
The role of transposon activity in shaping cis-regulatory element evolution after whole genome duplication |
| 皮质纹状体动作控制固有的对立认知动机风格 |
Avila, C. |
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N/A |
Cortico-striatal action control inherent of opponent cognitive-motivational styles |
| 有效连接预测知觉决策信心、不确定性和速度的分布式神经编码 |
Asadpour, A. |
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N/A |
Effective connectivity predicts distributed neural coding of perceptual decision confidence, uncertainty and speed |
| 球形表型聚类 |
Nightingale, L. |
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N/A |
Spherical Phenotype Clustering |
| 多组织网络分析揭示JNK抑制对饮食蔗糖引起的大鼠代谢功能障碍的影响 |
Mardinoglu, A. |
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N/A |
Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats |
| 病毒适应与致死性突变的瞬时进化流行病学 |
Guillemet, M. |
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N/A |
Transient evolutionary epidemiology of viral adaptation and lethal mutagenesis |
| 深层组织空间组学：以高空间分辨率成像整个胚胎的转录组和亚细胞结构 |
Gandin, V. |
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N/A |
Deep-tissue spatial omics: imaging whole-embryo transcriptomics and subcellular structures at high spatial resolution |
| Rtc调控的RNA修复机制模型提示了增强抗生素效果的分子靶点。 |
Hindley, H. J. |
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N/A |
A mechanistic model of Rtc-regulated RNA repair suggests molecular targets to potentiate antibiotic effects |
| 整合代谢建模与成像技术用于筛选结直肠癌治疗靶点 |
Tavakoli, N. |
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N/A |
Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer |
| 2022年初印度突破性感染血清针对保守的隐秘5类表位，以对抗SARS-CoV-2变种的免疫逃逸。 |
Das Jana, I. |
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N/A |
Early 2022 breakthrough infection sera from India target the conserved cryptic class 5 epitope to counteract immune escape by SARS-CoV-2 variants |
| 通过深度突变扫描技术，解析MET受体酪氨酸激酶激酶结构域的耐药机制 |
Estevam, G. O. |
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N/A |
Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning |
| 功能基因嵌入提高了罕见变异的复杂遗传风险评分 |
Londhe, S. |
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N/A |
Functional gene embeddings improve rare variant polygenic risk scores |
| 细胞分化过程中基因表达的内在维度 |
Biondo, M. |
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N/A |
The intrinsic dimension of gene expression during cell differentiation |
| 在猪链球菌发病机制中荚膜多糖的调节合成 |
Wang, X. |
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N/A |
Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis |
| 钙从内质网向其他细胞器的转移在弓形虫中对最佳信号传导至关重要。 |
Li, Z.-H. |
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N/A |
Calcium transfer from the ER to other organelles for optimal signaling in Toxoplasma gondii. |
| 在帕金森病中，运动方向快速逆转期间，丘脑底核-皮层同步性的情境依赖性调制 |
Winkler, L. |
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N/A |
Context-Dependent Modulations of Subthalamo-Cortical Synchronization during Rapid Reversals of Movement Direction in Parkinson's Disease |
| 胸侧半切术后控制系带行走和分带行走时相持续时间的脊髓感觉运动回路的运作 |
Rybak, I. A. |
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N/A |
Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection |
| 巴巴利猕猴社交信息的化学特征 |
Weiss, B. M. |
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N/A |
Chemical signatures of social information in Barbary macaques |
| 农业集约化导致的遗传多样性丧失及有害突变暴露 |
Nolen, Z. J. |
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N/A |
Species-specific loss of genetic diversity and exposure of deleterious mutations following agricultural intensification |
| 多站点研究中基于扩散磁共振成像的结构连接组的协调 |
Shen, R. S. |
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N/A |
Harmonization of Diffusion MRI-based Structural Connectomes for Multi-site Studies |
| DeepPaint：一个用于细胞显像图像分类的深度学习工具包 |
Luna, D. |
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N/A |
DeepPaint: A deep-learning package for Cell Painting Image Classification |
| 受体信号放大定量分析：全激动剂的Kd/EC50比值作为增益参数 |
Buchwald, P. |
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N/A |
Quantification of Signal Amplification for Receptors: The Kd/EC50 Ratio of Full Agonists as a Gain Parameter |
| O-特异性抗原的丧失塑造了假单胞菌在小鼠临床前肺部感染模型中的微生物地理分布 |
Fraser, H. |
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N/A |
Loss of O-specific antigen shapes Pseudomonas aeruginosa microbiogeography in murine preclinical pulmonary infection model |
| 在空间导航过程中，对决策神经动力学的全脑表征 |
Haley, S. P. |
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N/A |
Cortex-wide characterization of decision-making neural dynamics during spatial navigation |
| 突破屏障：真菌毒素白念珠菌素在肠道芯片模型中破坏上皮完整性并诱发炎症 |
Morelli, M. |
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N/A |
Breaking barriers: the fungal toxin candidalysin disrupts epithelial integrity and induces inflammation in a gut-on-chip model |
| 禾本科姐妹种的基因组揭示了草类出现之前的关键代谢创新 |
Takeda-Kimura, Y. |
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N/A |
Genomes of Poaceae sisters reveal key metabolic innovations preceding the emergence of grasses |
| 4-甲基七叶皂苷（4-MU）可改善大鼠脑缺血/再灌注损伤后的学习和记忆能力。 |
Tamouk, S. |
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N/A |
4-Methyllumifrone (4-MU) can improve learning and memory after cerebral ischemia/reperfusion injury in rats |
| 耶氏解脂耶氏酵母中基因编码报告基因的总体评价 |
Zhang, H. |
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N/A |
General assessment of genetically-encoded reporters in Yarrowia lipolytica |
| 多核巨细胞是卵巢衰老的标志，具有独特的免疫和降解相关分子特征。 |
Converse, A. |
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N/A |
Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures |
| HIV-1蛋白编码序列存在于相关细菌中 |
Pelaez-Prestel, H. F. |
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N/A |
HIV-1 protein coding sequences are present in relevant bacteria |
| 葡萄糖感应ChREBP蛋白在糖尿病视网膜病变发病机制中的作用 |
Starr, C. R. |
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N/A |
Glucose-Sensing ChREBP Protein in the Pathogenesis of Diabetic Retinopathy |
| 从一位患有年轻型糖尿病10型（由杂合INS突变引起）的患者中衍生出的诱导多能干细胞系ERCi003-A的生成 |
Bastrich, A. |
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N/A |
Generation of an induced pluripotent stem cell line ERCi003-A derived from a patient with maturity-onset diabetes of the young type 10 caused by a heterozygous INS mutation |
| 非经典Sun1-Allan复合体在快速有丝分裂期间调控核膜重塑和基体/微管组织中心分离 |
Zeeshan, M. |
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N/A |
Non canonical Sun1-Allan complex orchestrates nuclear envelope remodelling and Basal Body/MTOC Segregation during rapid mitosis in Plasmodium |
| 一种新型SUN1-ALLAN复合物在恶性疟原虫快速闭合有丝分裂期间协调核膜两侧的双极中心粒分离 |
Zeeshan, M. |
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N/A |
A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium |
| 胞外HDAC6 ZnF UBP结构域增强足体介导的神经元迁移 |
Qureshi, T. |
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N/A |
Extracellular HDAC6 ZnF UBP domain enhances podosome-mediated neuronal migration |
| 从一名年轻型糖尿病3型患者的皮肤成纤维细胞中生成了iPSC系ERCi004-A，该患者因HNF1A基因的杂合突变而患病。 |
Bastrich, A. |
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N/A |
Generation of iPSC line ERCi004-A from human dermal fibroblasts of a patient with maturity-onset diabetes of the young type 3 caused by a heterozygous mutation in the HNF1A gene |
| 自闭症蛋白质在纤毛处的汇聚 |
Kostyanovskaya, E. |
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N/A |
Convergence of autism proteins at the cilium |
| 自闭症蛋白在纤毛处的汇聚 |
Kostyanovskaya, E. |
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N/A |
Convergence of autism proteins at the cilium |
| EOR-1/PLZF调控的WAH-1/AIF依次促进非凋亡性尸体清除的早期和晚期阶段 |
Rather, N. |
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N/A |
EOR-1/PLZF-regulated WAH-1/AIF sequentially promotes early and late stages of non-apoptotic corpse removal |
| EOR-1/PLZF调控的WAH-1/AIF依次促进非凋亡性尸体清除的早期和晚期阶段 |
Rather, N. |
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N/A |
EOR-1/PLZF-regulated WAH-1/AIF sequentially promotes early and late stages of non-apoptotic corpse removal |
| 缺血后处理的心脏保护作用是通过抑制RAP2C-MAP4K4通路介导的 |
Zhang, M. |
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N/A |
The Cardioprotective Effect of Ischemic Postconditioning is Mediated by Inhibiting RAP2C-MAP4K4 Pathway |
| 抑制巨核细胞中RhoA介导的分泌性自噬可减轻小鼠的骨髓纤维化 |
Becker, I. C. |
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N/A |
Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice |
| 热应激对卵巢、卵泡和卵母细胞的影响：系统综述 |
Zhou, L. T. |
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N/A |
The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review |
| CGC1，一种新的大肠杆菌参考基因组 |
Ichikawa, K. |
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N/A |
CGC1, a new reference genome for Caenorhabditis elegans |
| 生物分子凝聚物通过可移动的锚定物促进膜润湿 |
GrandPre, T. |
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N/A |
Membrane wetting by biomolecular condensates is facilitated by mobile tethers |
| AER-270和TGN-020不是水通道蛋白-4水通道阻断剂。 |
Unger, L. |
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N/A |
AER-270 and TGN-020 are not aquaporin-4 water channel blockers |
| 肠道微生物群认知：我们对肠道微生物群了解多少？一项国际问卷调查。 |
Garcia-Gutierrez, E. |
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N/A |
Gut MicrobiotAware: how much do we know about gut microbiota? An international questionnaire. |
| 隐孢子虫胞内生存所需的主机基因揭示了可用于治疗的代谢依赖性 |
Marzook, N. B. |
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N/A |
The essential host genome for Cryptosporidium intracellular survival exposes metabolic dependencies that can be leveraged for treatment |
| 索莫莫浅井水中沙门氏菌的表征及其对肯尼亚埃尔多雷特莫里加·奥列费拉种子提取物的抗菌敏感性 |
Cheronoh, J. |
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N/A |
Characterization of Salmonella typhi from Shallow Well Water in Sogomo, Eldoret- Kenya and its Antimicrobial Sensitivity to Moringa oleifera Seed Extract |
| CHD4与TBX5相互作用，以维持出生后心房肌细胞的基因调控网络 |
Sweat, M. E. |
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N/A |
CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes |
| 利用联合物种分布模型检测群落中的生态进化动力学 |
Pantel, J. H. |
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N/A |
Detection of eco-evolutionary dynamics in communities using Joint Species Distribution Models |
| 芸苔属植物和其传粉者之间的相互作用受到蜜蜂群落管理和新烟碱类种子处理的影响。 |
Nottebrock, H. |
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N/A |
Interactions between Brassica carinata and its pollinators is shaped by managed beehives and neonicotinoid seed treatment |
| 低投入土壤管理在提高产量和减少二氧化碳排放的同时，却加剧了气候变化下冬小麦种植系统中硝酸盐淋失和病害的风险。 |
Michel, J. |
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N/A |
Low-input soil management increases yield and decreases CO2-emissions but aggravates risk of nitrate leaching and diseases in winter wheat cropping systems under climate change |
| 大陆边缘沉积物中甲烷循环古菌丰度、群落结构及分解代谢途径的驱动因素 |
Deng, L. |
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N/A |
Drivers of methane-cycling archaeal abundances, community structure, and catabolic pathways in continental margin sediments |
| 小RNA调控与基因组和谐：对沼泽兰花（Dactylorhiza）异源多倍体进化的见解 |
Eriksson, M. C. |
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N/A |
Small RNAs regulation and genomic harmony: insights into allopolyploid evolution in marsh orchids (Dactylorhiza) |
| 年龄和性激素对女性在整个成年期神经肌肉功能的影响 |
O'Bryan, S. J. |
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N/A |
The effect of age and sex hormones on female neuromuscular function across the adult lifespan |
| 增强CAR-T细胞的狂犬病毒受限于I型干扰素和快速收缩 |
Burchett, R. |
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N/A |
Boosting of CAR-T cells with rhabdovirus is limited by type I interferon and rapid contraction |
| 贝叶斯最小二乘超树（BLeSS）：灵活推断大型时间校准系统发育树 |
Cerny, D. |
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N/A |
Bayesian Least-Squares Supertrees (BLeSS): flexible inference of large time-calibrated phylogenies |
| 基于有限元分析的股骨颈骨折固定生物力学评估 |
Rao, L. |
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N/A |
Biomechanical Evaluation of Femoral Neck Fracture Fixation Based on Finite Element Analysis |
| 通过DECIPHER实现大规模异质空间组学的高保真解耦细胞嵌入 |
Xia, C.-R. |
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N/A |
High-fidelity disentangled cellular embeddings for large-scale heterogeneous spatial omics via DECIPHER |
| 评估基于性别和种族的基因表达综合数据库（GEO）数据集中的多样性、公平性和包容性（DEI）偏见 |
Gondal, M. N. |
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N/A |
Assessing DEI Bias in Gene Expression Omnibus (GEO) Datasets Based on Gender and Ethnicity |
| 脑肿瘤和黑色素瘤来源的细胞系对替莫唑胺的敏感性：与MGMT基因表达的关系 |
Baguley, B. C. |
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N/A |
Sensitivity to temozolomide of cell lines derived from brain tumours and melanomas: relationship to MGMT gene expression |
| 巨胞饮作用调控代谢应激驱动的胰腺癌中癌症相关成纤维细胞亚型身份 |
Zhang, Y. |
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N/A |
Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer |
| 性别特异性见解：药物诱导的小鼠寿命延长与体重减轻 |
Belikov, A. V. |
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N/A |
Sex-specific insights into drug-induced lifespan extension and weight loss in mice |
| 酒精会下调原肠胚基因表达和细胞运动，导致胎儿酒精谱系障碍的症状。 |
Alsakran, A. A. |
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N/A |
Ethanol down-regulates gastrula gene expression and cell movement, causing symptoms of foetal alcohol spectrum disorders |
| 建模决策和反馈控制在变化环境中对生物体的利弊 |
Kumar, R. |
PDF |
N/A |
Modelling benefits and costs of decision making and feedback control for organisms in changing environments |
| 系统生物学的通用微分方程：当前状态与开放问题 |
Philipps, M. |
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N/A |
Universal differential equations for systems biology: Current state and open problems |
| 患者来源的PBMCs的体外扩增优先导致效应记忆T细胞的增殖，并恢复了HBV-HCC中的自体效率。 |
Kah, J. |
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N/A |
Ex-vivo expansion of patient-derived PBMCs preferentially results in effector memory T-cell proliferation with restored autologous efficiency in HBV-HCC |
| 海洋青鳉对二噁英的反应与其近亲淡水青鳉（日本青鳉）有所不同：其AHR分子机制存在差异。 |
Zhang, W. |
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N/A |
Marine medaka responds differently to dioxin compared with its close freshwater relative, the Japanese medaka: the AHR molecular mechanism |
| 揭示未特征化的NSP结构和功能意义以及在哺乳动物和非哺乳动物动脉病毒分子工具包中的变异 |
Rakesh, S. |
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N/A |
Uncovering the Structural and Functional Implications of Uncharacterized NSPs and Variations in the Molecular Toolkit Across Mammalian and Non-Mammalian Arteriviruses |
| 识别潜在人群特征对风险因素的效应修饰作用：基于稀疏变化的系数回归 |
Wang, R. |
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N/A |
Identifying Effect Modification of Latent Population Characteristics on Risk Factors with a Sparse Varying Coefficient Regression |
| 通过快速进化的免疫开关实现Argonaute的动态调控 |
Ewe, C. K. |
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N/A |
Dynamic Control of Argonautes by a Rapidly Evolving Immunological Switch |
| 人类下肢活动信号提取与分类的肌音图研究 |
Bai, Y. |
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N/A |
An Investigation into Mechanomyography for Signal Extraction and Classification of Human Lower Limb Activity |
| 使用量子退火进行多序列比对的可扩展引导树构建 |
Park, Y. |
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N/A |
Scalable Guide Tree Construction Using Quantum Annealing for Multiple Sequence Alignment |
| 自动细胞类型注释与参考簇映射 |
Galanti, V. |
PDF |
N/A |
Automated Cell Type Annotation with Reference Cluster Mapping |
| 使用预训练的Transformer模型预测肿瘤基因表达的组织来源 |
Mellors, T. |
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N/A |
Predicting Tissue of Origin from Bulk Tumor Gene Expression using a Pre-trained Transformer Model |
| 用于分析单细胞分辨率相互作用的稀疏降维 |
Brunn, N. |
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N/A |
Sparse dimensionality reduction for analyzing single-cell-resolved interactions |
| 本地单体型分类器能够实现高效、灵活且安全的基因型推断及下游分析 |
Cheema, M. N. |
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N/A |
Local Haplotype Classifiers enable Efficient, Flexible, and Secure Genotype Imputation and Downstream Analyses |
| 通过利用外显子组测序数据中的脱靶读取，识别与基因组特征相关的新基因和表型关联 |
Ercelen, D. |
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N/A |
Identifying novel genetic and phenotypic associations to genomic features by leveraging off-target reads in exome sequencing data |
| 氨基酸转移自由能揭示生物分子凝聚物形成的热力学驱动力 |
Rekhi, S. |
PDF |
N/A |
Amino Acid Transfer Free Energies Reveal Thermodynamic Driving Forces in Biomolecular Condensate Formation |
| 移动肌球蛋白马达驱动的集群形成与相分离在运动实验中的作用 |
Slater, B. |
PDF |
N/A |
Cluster Formation and Phase Separation Driven by Mobile Myosin Motors in the Motility Assay |
| 扩展质量（eQual）：基于n元相似性的径向阈值聚类 |
Chen, L. |
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N/A |
Extended Quality (eQual): Radial threshold clustering based on n-ary similarity |
| α-突触核蛋白敲除损害了黑色素瘤的发展，并以性别依赖的方式改变了TG3小鼠模型中的DNA损伤修复 |
Arnold, M. R. |
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N/A |
Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner |
| 皮肤人乳头瘤病毒E6损害cGAS-STING通路 |
Tolbert, E. |
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N/A |
Cutaneous human papillomavirus E6 impairs the cGAS-STING pathway |
| 去甲基化药物对急性髓性白血病小鼠模型中白血病微环境基因调控及疾病进程的影响 |
Ebelt, N. D. |
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N/A |
Effects of Hypomethylating Agents on Gene Modulation in the Leukemic Microenvironment and Disease Trajectory in a Mouse Model of AML |
| 多组学分析揭示了鼻咽鳞状细胞癌中的恶性亚群及缺氧驱动的血管生成轴作为治疗脆弱性 |
You, C. |
PDF |
N/A |
Multi-omic profiling identifies malignant subpopulations and a hypoxia-driven angiogenic axis as therapeutic vulnerabilities in sinonasal squamous cell carcinoma |
| 腺病毒对IRE1α-XBP1信号通路的动态调控 |
Jang, Y. |
PDF |
N/A |
Dynamic modulation of IRE1α-XBP1 signaling by adenovirus |
| 空间单细胞转录组分析揭示了一种新型DICER1综合征小鼠模型（GEMM）的细胞起源及其相关肉瘤的发展层次 |
Kommoss, F. K. |
PDF |
N/A |
Spatial single cell transcriptomic analysis of a novel DICER1 Syndrome GEMM informs the cellular origin and developmental hierarchy of associated sarcomas |
| 脑老化过程中的微血管搏动及其在麻醉中的混杂效应 |
Skott, M. V. |
PDF |
N/A |
Microvascular pulsatility of the ageing brain and confounding effects of anaesthesia |
| 在心脏收缩功能受损的患者中，左心室停滞是由血流输送而非射血分数决定的。 |
Martinez-Legazpi, P. |
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N/A |
Flow transport and not ejection fraction determines left ventricular stasis in patients with impaired systolic function |
| 溪刺鱼（Culaea inconstans）栖息于中性及碱性湖泊中，其碱耐受性的种内差异 |
Zimmer, A. M. |
PDF |
N/A |
Intraspecific differences in alkaline tolerance in brook stickleback (Culaea inconstans) inhabiting neutral and alkaline lakes |
| 研究慢性短睡眠对新陈代谢和氧化应激生存的影响 |
Tener, S. J. |
PDF |
N/A |
Investigating the consequences of chronic short sleep for metabolism and survival of oxidative stress |
| 工蜂羽化后立即发生的代谢变化 |
Verbinnen, G. |
PDF |
N/A |
Shifts in honeybee worker metabolism immediately post-eclosion |
| 通过生长辅助正反馈的超弹道细胞间信号传导 |
Wang, M. |
PDF |
N/A |
Hyperballistic intercellular signaling through growth assisted positive feedback |
| 备忘录：一种微型备忘录传感器，利用精确的无细胞表达平台检测微RNA-RISC |
Copeland, C. E. |
PDF |
N/A |
MEMO: A Micro Memo Sensor Detecting microRNA-RISC using an Accurate Cell-Free Expression Platform |
| RNA结合蛋白调控生发中心B细胞的G2-M检查点 |
Salerno, F. |
PDF |
N/A |
RNA-binding proteins control the G2-M checkpoint of the germinal centre B cell |
| 协调数字化植物标本数据以增强生物多样性知识：为格陵兰植物区系创建更新清单。 |
Whitley, B. S. |
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N/A |
Harmonising digitised herbarium data to enhance biodiversity knowledge: creating an updated checklist for the flora of Greenland. |
| 渔业监测还是鱼类监测？尽管存在保护危机，三文鱼产卵监测的减少仍在持续 |
Atkinson, E. M. |
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N/A |
Monitoring for fisheries or for fish? Declines in monitoring of salmon spawners continue despite a conservation crisis |
| 高频鸣叫蟋蟀（Eneopterinae）前翅超微结构的比较研究 |
ROYER, L. |
PDF |
N/A |
Comparative forewing ultrastructure of high-frequency singing crickets (Eneopterinae) |
| 即使在实际温度没有变化的情况下，对温度的感知也足以驱动跨代表观遗传的遗传。 |
Teichman, G. |
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N/A |
Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance |
| 人类真菌病原体新生隐球菌交配型位点编码的关键基因 |
Bian, Z. |
PDF |
N/A |
Essential genes encoded by the mating-type locus of the human fungal pathogen Cryptococcus neoformans |
| 多维变量剂量分析（mVDA）是一种用于高通量绘制遗传相互作用的新方法。 |
Sengupta, S. |
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N/A |
Multidimensional variable dose analysis (mVDA) is a novel method for high-throughput mapping of genetic interactions |
| 增强果蝇细胞遗传检测的方法 |
Wang, Y. |
PDF |
N/A |
Enhanced methods for genetic assays in Drosophila cells |
| 一个解析谱系的多模态单细胞图谱揭示了早期秀丽隐杆线虫发育的基因组动力学 |
van der Burght, S. N. |
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N/A |
A lineage-resolved multimodal single-cell atlas reveals the genomic dynamics of early C. elegans development |
| 一种用于在Cauloacter crescentus中高效快速进行基因组编辑的CRISPR/SpCas9M-报告系统 |
Sun, J. |
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N/A |
A CRISPR/SpCas9M-reporting system for efficient and rapid genome editing in Caulobacter crescentus |
| 在蛋白质结构标记器中平衡局部性与重构性 |
Meynard-Piganeau, B. |
PDF |
N/A |
Balancing Locality and Reconstruction in Protein Structure Tokenizer |
| CellSexID：基于性别的嵌合模型细胞起源计算追踪 |
Tai, H. |
PDF |
N/A |
CellSexID: Sex-Based Computational Tracking of Cellular Origins in Chimeric Models |
| ProtSpace：一种用于可视化蛋白质空间的工具 |
Senoner, T. |
PDF |
N/A |
ProtSpace: a tool for visualizing protein space |
| 一种从低覆盖率测序数据中进行常见变异基因分型的高效新算法 |
Zhang, S. |
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N/A |
A Novel Efficient Algorithm for Common Variants Genotyping from Low-Coverage Sequencing Data |
| 准确的通用DNA表征在基因组基础模型的大规模应用中显现 |
Ellington, C. N. |
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N/A |
Accurate and General DNA Representations Emerge from Genome Foundation Models at Scale |
| RNA-DNA和DNA-DNA相互作用组的联合分析揭示了它们之间的强关联性。 |
Zvezdin, D. S. |
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N/A |
Joint analysis of RNA-DNA and DNA-DNA interactomes reveals their strong association |
| 人牛磺酸转运蛋白TauT的结构揭示了底物识别与抑制机制 |
lu, Y. |
PDF |
N/A |
Structure of the human taurine transporter TauT reveals substrate recognition and mechanisms of inhibition |
| 将分子尺度与细胞尺度相结合，用于膜受体信号传导模型 |
Peterson, K. J. |
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N/A |
Bridging molecular to cellular scales for models of membrane receptor signaling |
| DNA张力计揭示了驱动蛋白-1、-2和-3的捕获键解离动力学 |
Noell, C. R. |
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N/A |
DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3 |
| 电压门控钙通道失调可能参与钙调蛋白病神经症状的发生 |
Hussey, J. W. |
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N/A |
Voltage Gated Calcium Channel Dysregulation May Contribute to Neurological Symptoms in Calmodulinopathies |
| 力场极化对蛋白质集体运动的影响 |
Milinski, A. |
PDF |
N/A |
Impact of force field polarization on the collective motions of proteins |
| 靶细胞张力调控巨噬细胞吞噬作用 |
Cornell, C. E. |
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N/A |
Target cell tension regulates macrophage trogocytosis |
| IFNγ依赖的代谢重编程抑制了黑色素瘤中不成熟、促转移的淋巴状态。 |
Karakousi, T. |
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N/A |
IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma |
| 解析由免疫系统控制的休眠转移的表型 |
Chamorro, V. |
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N/A |
Unraveling the Phenotype of Dormant Metastases Controlled by the Immune System |
| 氧化还原催化亚基冗余性使N-糖基化的治疗靶向成为可能 |
Baro, M. |
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N/A |
OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation |
| 系统生物学引导的NF-κB和BCL2靶向克服了DLBCL中微环境介导的BH3模拟物耐药性。 |
Vareli, A. |
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N/A |
Systems biology-enabled targeting of NF-κB and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL. |
| 源自患者的肝细胞癌（HCC）细胞再现了与原发性HCV相关肝癌的转录组特征。 |
Kah, J. |
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N/A |
Patient-derived HCC cells recapitulating the transcriptomic landscape of primary HCV-related liver cancer |
| 大麻二酚促进细胞凋亡并下调致癌因子 |
Greenwood, A. L. |
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N/A |
Cannabidiol promotes apoptosis and downregulation of oncogenic factors |
| 节食通过诱导持久的肠道菌群失调，使小鼠的摄食行为失调。 |
Fouesnard, M. |
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N/A |
Yo-yo dieting deregulates feeding behavior in mice via the induction of durable gut dysbiosis |
| 哺乳至断奶过渡期间肠道上皮转录组变化的单细胞图谱 |
Malonga, T. |
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N/A |
A single-cell atlas of transcriptome changes in the intestinal epithelium at the suckling-to-weaning transition |
| 在内在无序的转录激活域中，功能保守而氨基酸序列不保守 |
LeBlanc, C. J. |
PDF |
N/A |
Conservation of function without conservation of amino acid sequence in intrinsically disordered transcriptional activation domains |
| 发现独立调控健康寿命和最大寿命的热力学控制变量 |
Denisov, K. A. |
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N/A |
Discovery of Thermodynamic Control Variables that Independently Regulate Healthspan and Maximum Lifespan |
| 异常的eNK细胞在宫腔粘连患者中促进子宫内膜纤维化 |
Zhou, Z. |
PDF |
N/A |
Abnormal eNK cells contribute to endometrial fibrosis in intrauterine adhesions patients |
| 细胞因子动态与氧化应激在宿主细胞中对耐药和敏感结核分枝杆菌分离株的刺激反应 |
Kumar, K. |
PDF |
N/A |
Cytokine Dynamics and Oxidative Stress in Host Cells Stimulated with Drug-Resistant and Sensitive Mycobacterium tuberculosis Isolates |
| 人免疫系统人源化-DRAGA小鼠是一个有价值的研究新型HIV-1免疫疗法的模型。 |
Pumtang-on, P. |
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N/A |
Human-immune-system humanized-DRAGA mice are a valuable model to study novel immunotherapies for HIV-1 |
| 多花紫藤凝集素通过与扎伊尔埃博拉病毒糖蛋白复合物上特定N-连接糖基化位点的相互作用，增强了病毒的进入过程。 |
Duncan, J. D. |
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N/A |
Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex |
| 有颌脊椎动物（Gnathostomata）胃的进化：通过基因组损失的研究——来自无胃物种的发现 |
Dann, J. B. |
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N/A |
Evolution of the Jawed Vertebrate (Gnathostomata) Stomach through Gene Repertoire Loss: Findings from Agastric Species |
| 热感受神经元通过调节生殖系转座子来控制遗传继承。 |
Szanto, P. |
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N/A |
Thermosensory neurons control genetic inheritance through regulation of germline transposons |
| 三种入侵昆虫的基因组草图及转录组序列数据 |
Lombaert, E. |
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N/A |
Draft genome and transcriptomic sequence data of three invasive insect species |
| 糖尿病预防计划研究中的糖尿病前期表型聚类 |
Stroebel, B. M. |
PDF |
N/A |
Prediabetes Phenotype Clusters in the Diabetes Prevention Program Study |
| 时间通过CpG位点簇的甲基化变化进行编码 |
Ochana, B.-L. |
PDF |
N/A |
Time is encoded by methylation changes at clustered CpG sites |
| 阿尔茨海默病中单细胞水平上性别和APOE基因型特异性转录变化的风貌 |
Yu, G. |
PDF |
N/A |
The Landscape of Sex- and APOE Genotype-Specific Transcriptional Changes in Alzheimer's Disease at the Single Cell Level |
| 一种极简主义的二进制/数字方法，利用光学标记的tRNAs和多种羧肽酶进行大规模单分子蛋白质鉴定，并将其扩展到肽段测序。 |
Sampath, G. |
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N/A |
A minimalist binary/digital approach to large-scale single molecule protein identification with optically labeled tRNAs and multiple carboxypeptidases and its extension to peptide sequencing |
| 可以使用耳内和耳周的脑电极来估计言语接受阈值。 |
Borges, H. B. |
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N/A |
The Speech Reception Threshold Can be Estimated Using EEG Electrodes In and Around the Ear |
| 人诱导多能干细胞衍生的运动神经支配增强了使用桌面制造技术工程化的肌肉束的分化 |
Santoso, J. W. |
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N/A |
Human iPSC-derived motor neuron innervation enhances the differentiation of muscle bundles engineered with benchtop fabrication techniques |
| abCAN：一种实用且新颖的注意力网络，用于预测突变抗体亲和力 |
Gong, C. |
PDF |
N/A |
abCAN: a Practical and Novel Attention Network for Predicting Mutant Antibody Affinity |
| 负二项隐因子模型用于配对微生物组测序数据 |
Kim, H. |
PDF |
N/A |
A negative binomial latent factor model for paired microbiome sequencing data |
| 缓解光谱学揭示了贝达喹啉在活体分枝杆菌中的作用机制 |
Harrison, S. H. |
PDF |
N/A |
Remission spectroscopy resolves the mode of action of bedaquiline within living mycobacteria |
| Q/R编辑和选择性过滤器突变对GluA2 AMPA受体钙通透性原子机制的调节 |
Heiser, F. |
PDF |
N/A |
Atomistic Mechanisms of Calcium Permeation Modulated by Q/R Editing and Selectivity Filter Mutations in GluA2 AMPA Receptors |
| 通过细胞外基质（ECM）进行的机械通信依赖于频率，这是由于细胞对机械信号形状的敏感性所致。 |
Nitsan, I. |
PDF |
N/A |
Mechanical communication through the ECM is frequency-dependent due to cell sensitivity to mechanical signal shape |
| 蛋白质-蛋白质界面中的挫败感在PROTAC三元复合物的协同作用中起着核心作用 |
Ma, N. |
PDF |
N/A |
Frustration in the Protein-Protein interface Plays a Central Role in the Cooperativity of PROTAC Ternary Complexes |
| 堂娜·弗洛尔和她的两个丈夫：发现新型HDAC6/AKT2抑制剂用于髓系癌症治疗 |
Waitman, K. B. |
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N/A |
Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment |
| 对立谱系调控因子诱导肺腺癌中的促肿瘤混合身份状态 |
Fort, G. |
PDF |
N/A |
Opposing lineage specifiers induce a pro-tumor hybrid-identity state in lung adenocarcinoma |
| MOZ和HBO1组蛋白乙酰转移酶复合物是NUP98重排急性髓系白血病的分子依赖性和治疗靶点 |
Mullighan, C. G. |
PDF |
N/A |
MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia |
| 环状RNA - circCLIP2主要在胶质母细胞瘤干细胞（GSC）微环境中表达，并通过上皮间质转化（EMT）和细胞外基质（ECM）信号传导途径增强胶质母细胞瘤的侵袭性。 |
Misiorek, J. O. |
PDF |
N/A |
Circular RNA - circCLIP2 is predominantly expressed in GSC niche and enhances glioblastoma aggressiveness via EMT and ECM signaling |
| Gankyrin/PSMD10下调影响胶质母细胞瘤中癌细胞的生长和增殖：体外和体内研究 |
Travnikova, D. |
PDF |
N/A |
Downregulation of Gankyrin/PSMD10 affects cancer cell growth and proliferation in glioblastoma: in vitro and in vivo study |
| 通过超快化学蛋白质组学研究Pt(IV)与氯尼达明配体的作用机制 |
Imaikina, E. A.. |
PDF |
N/A |
Study on the mechanism of action of the Pt(IV) complex with lonidamine ligands by ultrafast chemical proteomics |
| 表型分析隐藏的一半：结合无人机表型分析和机器学习预测田间大麦根系性状 |
Alahmad, S. |
PDF |
N/A |
Phenotyping the hidden half: Combining UAV phenotyping and machine learning to predict barley root traits in the field |
| 探究DI-DII连接子在Nav1.5通道功能中的作用 |
Wagner, E. |
PDF |
N/A |
Investigating the Functional Role of the DI-DII Linker in Nav1.5 Channel Function |
| 在棕色脂肪细胞特异性缺失ATGL和HSL的情况下，非颤抖性产热功能保持完整，这可能是由于白色脂肪组织的棕色化作用。 |
Manandhar, Y. |
PDF |
N/A |
Non-shivering thermogenesis is intact upon brown-adipocyte specific loss of ATGL and HSL due to white adipose tissue browning |
| 外周人多形核白细胞激活和吞噬作用的高维光谱流式细胞术分析 |
Lamb, E. R. |
PDF |
N/A |
High-dimensional spectral flow cytometry of activation and phagocytosis by peripheral human polymorphonuclear leukocytes |
| CD226+ 脂肪组织巨噬细胞源自MDP衍生的单核细胞，并调节脂质代谢。 |
Gallerand, A. |
PDF |
N/A |
CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism. |
| 单倍二倍性加速昆虫线粒体基因组进化 |
Pakrashi, A. |
PDF |
N/A |
HAPLODIPOIDY ACCELERATES MITOGENOME EVOLUTION IN INSECTS |
| SynapseNet：深度学习在自动突触重建中的应用 |
Muth, S. |
PDF |
N/A |
SynapseNet: Deep Learning for Automatic Synapse Reconstruction |
| 负电荷基团在抗菌阳离子肽模拟物中的作用：对膜相互作用的深入理解 |
Saiba, R. |
PDF |
N/A |
The Role of Negatively Charged Groups in Antimicrobial Cationic Peptide Mimics: Insights into Membrane Interactions |
| 语言复杂性在听觉和言语刺激神经处理中的时间性和半球动态变化：一项MEG源空间研究 |
Krauss, P. |
PDF |
N/A |
Temporal and Hemispheric Dynamics in Neural Processing of Auditory and Speech Stimuli Across Linguistic Complexity: A MEG Source Space Study |
| 利用结合的脑电图（EEG）和脑磁图（MEG）测量分析人类大脑中处理名词和动词的差异 |
Koelbl, N. |
PDF |
N/A |
Analyzing Differences in Processing Nouns and Verbs in the Human Brain using Combined EEG and MEG Measurements |
| GET3B与类囊体ALB3和ALB4插入酶相互作用，并参与叶绿体生物发生的初始阶段。 |
Bodensohn, U. |
PDF |
N/A |
GET3B interacts with the thylakoidal ALB3 and ALB4 insertases and is involved in the initial stages of chloroplast biogenesis |
| 通过hTERT使间充质基质细胞永生化，不会影响分泌的外泌体的功能特性。 |
Brancolini, A. |
PDF |
N/A |
Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles |
| CENcyclopedia：细胞周期中着丝粒结构的动态景观 |
Chen, Y.-C. |
PDF |
N/A |
CENcyclopedia: Dynamic Landscape of Kinetochore Architecture Throughout the Cell Cycle |
| TMEM251对GNPTAB调控的分子洞察 |
Yang, X. |
PDF |
N/A |
Molecular Insights into the Regulation of GNPTAB by TMEM251 |
| 冲突的时间线：探索四足动物分歧估计中线粒体-核不一致的模式 |
Ranganathan, E. |
PDF |
N/A |
Conflicting Timelines: Exploring patterns of mito-nuclear discordance in divergence estimates among tetrapods |
| 用于脊髓损伤治疗的植入式3D打印多通道微通道 |
Grebenyuk, S. |
PDF |
N/A |
Implantable 3D printed multiplexed microtunnels for spinal cord injury treatment |
| 研究成纤维细胞靠近肿瘤对其胞外囊泡生成的影响，利用3D生物打印的基质模型 |
Amens, J. N. |
PDF |
N/A |
Investigating the impact of fibroblast proximity to a tumor on fibroblast extracellular vesicle production utilizing 3D bioprinted stromal models |
| 用于免疫防御创伤性脑损伤的疫苗 |
Acharya, A. P. |
PDF |
N/A |
Vaccines for immunological defense against traumatic brain injury |
| 用于检测HG002 Genome In A Bottle NIST参考材料中低频变异体的稳健基准。 |
Daniels, C. |
PDF |
N/A |
A robust benchmark for detecting low-frequency variants in the HG002 Genome In A Bottle NIST reference material. |
| CoLaML：从异质基因内容中推断潜在的进化模式 |
Yamanouchi, S. |
PDF |
N/A |
CoLaML: Inferring latent evolutionary modes from heterogeneous gene content |
| 用于蛋白质结构预测的检索增强蛋白质语言模型 |
Li, P. |
PDF |
N/A |
Retrieval Augmented Protein Language Models for Protein Structure Prediction |
| 使用机器学习预测小分子抗菌药物类别特异性 |
Gadiya, Y. |
PDF |
N/A |
Predicting antimicrobial class specificity of small molecules using machine learning |
| GAPDH的RNA结合调控急性髓系白血病中转录本的稳定性和蛋白质翻译 |
Imig, J. |
PDF |
N/A |
RNA Binding of GAPDH Controls Transcript Stability and Protein Translation in Acute Myeloid Leukemia |
| 多灶性小肠神经内分泌肿瘤的表观遗传学研究揭示了肿瘤加速老化及代谢基因的表观遗传学改变 |
Webster, A. P. |
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N/A |
Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes |
| 在离体猪角膜感染模型中，使用管道环稳定地局部应用抗菌药物 |
Foulkes, D. M. |
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N/A |
Stable topical application of antimicrobials using plumbing rings in an ex vivo porcine corneal infection model |
| 心肌梗死后11β羟基类固醇脱氢酶1型药理学抑制作用靶向外基质加工，并在小型猪模型中保护心脏功能 |
Al Disi, S. |
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N/A |
Pharmacological inhibition of 11βhydroxysteroid dehydrogenase type 1 after myocardial infarction targets extracellular matrix processing and preserves cardiac function in a translational mini-pig model |
| ROSLT：一种改进的树莓派开源实时自愿轮跑追踪方法和资源 |
Sanosa, P. |
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N/A |
ROSLT: An Improved Raspberry-Pi Open-Source Live Voluntary-Wheel Running Tracker Method and Resource |
| DoRIAT：一种用于解释和注释对接运行的贝叶斯框架。 |
Maniatis, C. |
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N/A |
DoRIAT: A Bayesian Framework For Interpreting And Annotating Docking Runs. |
| 利用Immunemap这一开放的活体显微镜图谱，对免疫细胞运动进行系统分析 |
Pizzagalli, D. U. |
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N/A |
Systematic analysis of immune cell motility leveraging Immunemap, an open intravital microscopy atlas |
| 巴西跳蚤科（半翅目：瘿蚜总科：瘿蚜科）中的Paurocephalini族跳蚤 |
Serbina, L. |
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N/A |
Jumping plant-lice of the tribe Paurocephalini (Hemiptera: Psylloidea: Liviidae) in Brazil |
| 果蝇大脑中已鉴定神经元的突触图谱分析 |
Wu, H. |
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N/A |
Synapse profiling of identified neurons in the Drosophila brain |
| 章鱼胺信号协调果蝇蘑菇体内突触前机制的空间模式 |
Wu, H. |
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N/A |
Octopamine signals coordinate the spatial pattern of presynaptic machineries in the Drosophila mushroom bodies |
| 新诊断类风湿性关节炎患者和健康当前吸烟者对照组支气管肺泡灌洗细胞HLA-DR免疫肽组学的特征 |
Zohrer, B. |
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N/A |
Characterization of HLA-DR immunopeptidome of bronchoalveolar lavage cells in patients with newly diagnosed rheumatoid arthritis and healthy current-smoker controls |
| 设计多型登革病毒疫苗：一种基于计算机的方法实现广谱免疫 |
Singh, A. |
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N/A |
Designing a multi-serotype Dengue virus vaccine: an in silico approach to broad-spectrum immunity |
| 揭示分层淡水湖中军团菌的生态：季节动态、宿主相互作用及在氧气有限条件下的持久性 |
Bergman, O. |
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N/A |
Unveiling the Ecology of Legionella in a Stratified Freshwater Lake: Seasonal Dynamics, Host Interactions, and Persistence Under Oxygen Limited Conditions |
| 被忽视的捕食性昆虫在濒危沿海栖息地中触发了潜在的关键生物多样性区域 |
Ascenzi, A. |
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N/A |
Neglected predatory insects trigger potential Key Biodiversity Areas in threatened coastal habitats |
| 海胆花属（Penstemon）中具人形花的独特形态基础及其平行演化历史 |
Depatie, T. H. |
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N/A |
The unique morphological basis and parallel evolutionary history of personate flowers in Penstemon |
| 基于系统发育的方法在灵长类动物中探索突变过程 |
Kitch, J. C. |
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A Phylogeny-Based Approach to Discover Mutational Processes in Primates |
| 形态上不同的群体是否对应于生殖隔离的物种？瑞士红蚁的一个案例研究 |
Lavanchy, G. |
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N/A |
Do morphologically distinct groups correspond to reproductively isolated species? A case study in Myrmica ants from Switzerland |
| 揭示甜菜驯化和育种中的关键基因 |
Dhiman, A. S. |
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N/A |
Uncovering Genes Essential in Domestication and Breeding of Sugar Beet |
| 基于Cas9的富集用于靶向长读段元条形码分析 |
Nikolaeva-Reynolds, L. |
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N/A |
Cas9-based enrichment for targeted long-read metabarcoding |
| ERGA-BGE 参考基因组：来自伊比利亚干旱地区的特有鞭蛛 |
Lozano-Fernandez, J. |
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N/A |
ERGA-BGE Reference Genome of Gluvia dorsalis: An Endemic Sun Spider from Iberian Arid Regions |
| RpiBeh：一种多用途的开源解决方案，用于实时追踪和基于行为的小鼠神经行为学闭环干预 |
Sun, Y. |
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N/A |
RpiBeh: a multi-purpose open-source solution for real-time tracking and behavior-driven closed-loop interventions in rodent neuroethology |
| 从仅包含序列的训练数据生成全原子蛋白质结构 |
Lu, A. X. |
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N/A |
Generating All-Atom Protein Structure from Sequence-Only Training Data |
| TROP2/Claudin程序介导免疫排斥，阻碍乳腺癌中的检查点阻断 |
Wu, B. |
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A TROP2/Claudin Program Mediates Immune Exclusion to Impede Checkpoint Blockade in Breast Cancer |
| 适应性复制原点激活改变了癌细胞中的染色质动力学和稳定性 |
Perez-Venteo, A. |
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N/A |
Adaptive replication origin activation alters chromatin dynamics and stability in cancer cells |
| 泛素连接酶ITCH调控SARS-CoV-2病毒的生命周期 |
Xiang, Q. |
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N/A |
Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus |
| 胶囊和遗传背景，而非特定基因座，对肺炎球菌生长动力学有强烈影响。 |
Chaguza, C. |
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N/A |
The capsule and genetic background, rather than specific loci, strongly influence pneumococcal growth kinetics |
| 痘病毒编码的E3样蛋白的差异可以决定痘病毒激活细胞坏死性凋亡 |
Enow, J. A. |
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Divergence in poxvirus-encoded E3-like proteins can dictate poxvirus activation of cellular necroptosis |
| 对来自Mastomys natalensis的三种巨细胞病毒的分子克隆及宿主范围分析 |
Staliunaite, L. |
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N/A |
Molecular cloning and host range analysis of three cytomegaloviruses from Mastomys natalensis |
| DynaMAP：通过高密度光学图谱进行动态微生物组丰度分析 |
Abakumov, S. |
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N/A |
DynaMAP: Dynamic Microbiome Abundance Profiling through high density optical mapping |
| 全基因组序列、代谢谱分析及功能研究揭示，Ligilactobacillus salivarius LS-ARS2是一种具有显著抗氧化、抗菌及抗生物膜潜能的生物膜形成型益生菌，显示出良好的应用前景。 |
Patra, S. |
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N/A |
Complete Genome Sequence, Metabolic Profiling and Functional Studies reveal Ligilactobacillus salivarius LS-ARS2 is a Promising Biofilm-forming Probiotic with Significant Antioxidant, Antibacterial, and Antibiofilm Potential |
| 有袋类动物肠道微生物组的宏基因组分析为低甲烷经济提供了遗传基础。 |
Bowerman, K. L. |
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N/A |
Metagenomic analysis of marsupial gut microbiomes provides a genetic basis for the low methane economy |
| 肠道微生物群物种Levilactobacillus brevis调节秀丽隐杆线虫的生殖适应性 |
Braun, N. J. |
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Gut microbiome species Levilactobacillus brevis regulates reproductive fitness in C. elegans |
| 对原噬菌体激活的进化响应减弱了可培养的蚜虫内共生菌Serratia symbiotica相关菌株的毒力。 |
VanDieren, A. J. |
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Evolution in response to prophage activation attenuates the virulence of culturable Serratia symbiotica relatives of aphid endosymbionts |
| 实验性噬菌体进化导致对多重耐药和广泛耐药肺炎克雷伯菌分离株的宿主范围扩大 |
Ghatbale, P. |
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Experimental Phage Evolution Results in Expanded Host Ranges Against MDR and XDR Klebsiella pneumoniae Isolates |
| 优化人源单克隆抗体以增强对SARS-CoV-2的中和作用 |
Wang, Q. |
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N/A |
Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2 |
| E-box独立染色质招募使MYOD转变为转录抑制因子 |
Nicoletti, C. |
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N/A |
E-box independent chromatin recruitment turns MYOD into a transcriptional repressor |
| 高通量表观遗传学分析免疫检测法，助力加速疾病研究和临床开发 |
Van den Ackerveken, P. |
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N/A |
High-Throughput Epigenetic Profiling Immunoassays for Accelerated Disease Research and Clinical Development |
| 工程化一种受炭疽毒素启发的蛋白质-配体，用于纳米颗粒介导的恶性黑色素瘤治疗 |
Marquez-Lopez, A. |
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N/A |
Engineering an Anthrax Toxin inspired protein-ligand for Nanoparticle-Mediated Treatment of Malignant Melanoma |
| 超过一半的注释人类miRNAs在表达水平上不足以执行其生物学功能。 |
Kachooei, S. A. |
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N/A |
More than half of annotated human miRNAs are never expressed at levels sufficient for biological function |
| Rad52通过一个大的C端85残基片段作为装配陪伴蛋白来形成和稳定Rad51纤维 |
Ma, E. |
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N/A |
Rad52 Acts as an Assembly Chaperone to Form and Stabilize Rad51 Filaments Through a Large C-Terminus 85-Residue Segment |
| Prp16能够高效剪接富含短内含子的隐球菌转录组中具有多样外显子一致性元件的内含子。 |
Negi, M. S. |
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N/A |
Prp16 enables efficient splicing of introns with diverse exonic consensus elements in the short-intron rich Cryptococcus neoformans transcriptome |
| 高通量定量miRNA-3'-非翻译区调控效应 |
Ding, Y. |
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N/A |
High-Throughput Quantification of miRNA-3'-Untranslated-Region Regulatory Effects |
| 使用斑马鱼hand2 Cre和CreERT2重组酶的CRISPR敲入进行谱系标记 |
Ming, Z. |
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N/A |
Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins |
| 药理浓度的维生素C能抑制髓过氧化物酶产生的次氯酸，而氧化态的维生素C则能抑制关键的硫醇蛋白并抑制Jurkat细胞的生长。 |
Peskin, A. V. |
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N/A |
Pharmacological concentrations of vitamin C inhibit hypochlorous acid generation by myeloperoxidase, and oxidized vitamin C inhibits critical thiol proteins and growth of Jurkat cells |
| Tau中天冬氨酸的异常快速异构化 |
Shoff, T. A. |
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N/A |
Unusually Rapid Isomerization of Aspartic Acid in Tau |
| 噼啪云：一种基于事件驱动的云端CRISPR-Cas9引导RNA设计工具 |
Bradford, J. |
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N/A |
Crackling Cloud: an event-driven, cloud-based CRISPR-Cas9 guide RNA design tool |
| 可扩展的深度生成学习模拟蛋白质平衡系综 |
Lewis, S. |
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N/A |
Scalable emulation of protein equilibrium ensembles with generative deep learning |
| 全面网络分析miRNA生物发生蛋白及其配体相互作用位点以识别癌症治疗的新靶点 |
Almhanna, H. |
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N/A |
Comprehensive Network Analysis of miRNA Biogenesis Proteins and Their Ligand Interaction Sites to Identify Novel Targets for Cancer Therapeutics |
| 铜绿假单胞菌PA14鞭毛介导的表面感应的遗传分析 |
Kuchma, S. |
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N/A |
Genetic Analysis of Flagellar-Mediated Surface Sensing by Pseudomonas aeruginosa PA14 |
| 缺乏多种氨基酸转运蛋白的酿酒酵母菌株的特性分析与全基因组测序：研究氨基酸转运的工具 |
Sonawala, U. |
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N/A |
Characterization and whole genome sequencing of Saccharomyces cerevisiae strains lacking several amino acid transporters: tools for studying amino acid transport |
| 抗VCAM-1抗体的分离与表征揭示了Ig样结构域2和3在细胞间相互作用中的潜在作用 |
Perera, B. |
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N/A |
Isolation and Characterization of Antibodies Against VCAM-1 Reveals Putative Role for Ig-like Domains 2 and 3 in Cell-to-Cell Interaction |
| CTP结合基序对S. coelicolor ParB与DNA、染色体分离及孢子形成菌丝生长的相互作用的重要性。 |
Szymczak, J. |
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N/A |
Significance of the CTP-binding motif for the interactions of S. coelicolor ParB with DNA, chromosome segregation and sporogenic hyphal growth. |
| 冷冻电镜显示，源自心脏IGLV6的AL纤维可以具有多态性。 |
Bassett, P. T. |
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N/A |
Cryo-EM reveals that cardiac IGLV6-derived AL fibrils can be polymorphic |
| 高通量分化人类血管类器官揭示脑静脉畸形蛋白的重叠与独特功能 |
Skowronek, D. |
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N/A |
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins |
| 针对基因剪接的靶向阻断可能会扰乱内含子嵌入的微小RNA的调控。 |
Ali, M. H. |
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N/A |
Targeted blocking of gene splicing can dysregulate intron-embedded microRNAs |