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图像平衡是一种自下而上的神经美学特性,介导着注意力和眼球运动。一个原始的视觉操作系统解释了平衡的属性,以及一种基本的视觉组织世界的方式。 Corwin, D. M. PDF N/A Pictorial balance is a bottom-up neuro-aesthetic property mediating attention and eye movements. A primitive visual operating system explains the property of balance and a primary visual way of organizing the world.
端粒酶依赖性斑马鱼大脑衰老 Martins, R. R. PDF N/A Telomerase-Dependent Ageing In The Zebrafish Brain
有丝分裂神经母细胞的检测为成年小肠肌间神经丛中持续的神经发生提供了额外证据。 Gorecki, A. M. PDF N/A Detection of mitotic neuroblasts provides additional evidence of steady state neurogenesis in the adult small intestinal myenteric plexus
TriScan:采用简单光学设计的快速、高灵敏度三维共聚焦荧光成像技术 Van den Eynde, R. PDF N/A The TriScan: fast and sensitive 3D confocal fluorescence imaging using a simple optical design
神经活动跨学科映射与受限玻尔兹曼机 Yang, H. PDF N/A Cross-subject Mapping of Neural Activity with Restricted Boltzmann Machines
依赖于偏心率的扫视反应时间:中央凹放大和注意定向的作用 Zhang, Y. PDF N/A Eccentricity-Dependent Saccadic Reaction Time: The Roles of Foveal Magnification and Attentional Orienting
神经网络在认知任务期间被调整至接近临界状态,而在阿尔茨海默病的精神药理学模型中则远离临界状态 Habibollahi, F. PDF N/A Neural Networks Are Tuned Near Criticality During a Cognitive Task and Distanced from Criticality In a Psychopharmacological Model of Alzheimer's Disease
在季节性缩小的过程中,白足鼩鼱的动态代谢和分子变化 Thomas, W. R. PDF N/A Dynamic metabolic and molecular changes during seasonal shrinking in Sorex araneus
硬骨鱼类幼体中多样的捕食策略 Mearns, D. S. PDF N/A Diverse prey capture strategies in teleost larvae
DNA损伤检查点1(MDC1)的共调节活性与乳腺小叶癌中的DNA修复功能障碍及PARP抑制剂敏感性相关 Sottnik, J. L. PDF N/A Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast
使用正未标注机器学习识别人类mRNA 5'UTR序列中的潜在核开关元件 Raymond, W. PDF N/A Identification of potential riboswitch elements in Homo Sapiens mRNA 5'UTR sequences using Positive-Unlabeled Machine learning
脂肪酸代谢和氧化应激反应支持细菌捕食 Jain, R. PDF N/A Fatty Acid Metabolism and The Oxidative Stress Response Support Bacterial Predation
LysM-RLK在植物中发挥着古老的共生功能 Teyssier, E. PDF N/A LysM-RLK plays an ancestral symbiotic function in plants
重组Physcomitrella FtsZ蛋白在体外依赖GTP的差异聚合作用 Milferstaedt, S. W. L. PDF N/A Differential GTP-dependent in-vitro polymerization of recombinant Physcomitrella FtsZ proteins
POMC神经元通过在Kisspeptin神经元中对MC4R的不同信号传导来控制生育能力。 Talbi, R. PDF N/A POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons
一个反馈驱动的脑类器官平台能够实现自动维护和高分辨率神经活动监测 Voitiuk, K. PDF N/A A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring
40S核糖体蛋白RPS26和RPS25的不足,在脆性X相关条件下,对含聚甘氨酸蛋白的生物合成产生负面影响。 Tutak, K. PDF N/A Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions
Wnt通路调控的细胞外基质蛋白聚糖的表达在东非慈鲷脂肪组织肥大的平行进化中起着重要作用。 Machii, N. PDF N/A Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids
成像流式细胞术能够实现从不可培养的细菌群体中对形态变异细胞的无标记分选。 Vocelle, D. PDF N/A Imaging flow cytometry enables label-free cell sorting of morphological variants from unculturable bacterial populations.
新型酿酒酵母群落生态发酵研究模型设计 Pourcelot, E. PDF N/A Design of a new model yeast consortium for ecological studies of enological fermentation
使用信息先验来解决存在鉴定错误的占据模型中的可识别性问题 Monchy, C. PDF N/A Using informative priors to account for identifiability issues in occupancy models with identification errors
在预测编码模型中平衡先验知识和感官数据:对精神分裂症中连贯运动检测的洞察 Nemati, E. PDF N/A Balancing Prior Knowledge and Sensory Data in a Predictive Coding Model: Insights into Coherent Motion Detection in Schizophrenia
动态调节小鼠海马体中由学习与记忆介导的NAT10介导的突触mRNA乙酰化 Zhou, H.-Q. PDF N/A Dynamic regulation of NAT10-mediated mRNA acetylation at synapses by learning and memory in mouse hippocampus
PathoGFAIR:一套符合FAIR原则且可适应的(元)基因组工作流程,用于(食源性)病原体的检测和追踪 Nasr, E. PDF N/A PathoGFAIR: a collection of FAIR and adaptable (meta)genomics workflows for (foodborne) pathogens detection and tracking
神经网络中模块性的出现与维持:基于Hebbian和反Hebbian抑制性STDP Bergoin, R. PDF N/A Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP
大规模并行遗传扰动揭示了淀粉样β核化反应的能量结构 Arutyunyan, A. PDF N/A Massively parallel genetic perturbation reveals the energetic architecture of an amyloid beta nucleation reaction
C-C趋化因子受体4缺乏加剧了小鼠早期动脉粥样硬化 Tanaka, T. PDF N/A C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice
预测无关信息:分心物可预测性的神经效应取决于任务负荷 Lui, T. K.-Y. PDF N/A Predicting the irrelevant: Neural effects of distractor predictability depend on load
面部表情和言语运动中的时空结构与子状态 Cuve, H. C. J. PDF N/A Spatiotemporal structure and substates in facial expressions and speech movements
关于蛋白质遗传结构分析:对“蛋白质序列景观并非如此简单”的回应 Park, Y. PDF N/A On the Analysis of Protein Genetic Architecture: Response to "Protein sequence landscapes are not so simple"
解码HIV诱导的CPSF6斑点的生物发生及其与核斑点的融合 Tomasini, C. PDF N/A Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle
用于神经场体内双光子荧光显微镜的自适应光学校正 Kang, I. PDF N/A Adaptive optical correction for in vivo two-photon fluorescence microscopy with neural fields
认知网络通过通信子空间在大规模新皮层模型中的交互作用 Pereira-Obilinovic, U. PDF N/A Cognitive networks interactions through communication subspaces in large-scale models of the neocortex
一个具有广泛宿主范围的锈菌中,假定效应因子的基因组内变异驱动了早期感染阶段 Degnan, R. PDF N/A Intragenomic variants of a putative effector drive early-stage infection in a broad host-range rust fungus
利用新型病毒工具探索CA3记忆细胞性质的早期变化 Cupolillo, D. PDF N/A Early changes in the properties of CA3 engram cells explored with a novel viral tool
识别基孔肯雅病毒nsP2 ATPase抑制剂 Navarro, H. PDF N/A Identification of Inhibitors of Chikungunya virus nsP2 ATPase
大规模信息先验用于更好地预测稀有树相关微生境的局部发生率 Cottais, P. PDF N/A Large-scale informative priors to better predict the local occurrence rate of a rare tree-related microhabitat
语言网络揭示了由基于结构域的词语构成的蛋白质句子的语法约束 Shimpi, A. A. PDF N/A Linguistic networks uncover grammatical constraints of protein sentences comprised of domain-based words
BEVA2.0:通过模块化组装扩展遗传工程应用的金门兼容载体系统 Geddes, B. A. PDF N/A BEVA2.0: Modular Assembly of Golden Gate-Compatible Vectors with Expanded Utility for Genetic Engineering
CGC1,一种新的秀丽隐杆线虫参考基因组 Ichikawa, K. PDF N/A CGC1, a new reference genome for Caenorhabditis elegans
评估基因表达综合数据库(GEO)数据集中的偏差 Gondal, M. N. PDF N/A Assessing Bias in Gene Expression Omnibus (GEO) Datasets
在蛋白质结构标记器中平衡局部性与重构性 Zhang, J. PDF N/A Balancing Locality and Reconstruction in Protein Structure Tokenizer
哺乳至断奶过渡期间肠道上皮转录组变化的单细胞图谱 Malonga, T. PDF N/A A single-cell atlas of transcriptome changes in the intestinal epithelium at the suckling-to-weaning transition
颌口类(Gnathostomata)胃的进化:通过基因组损失的研究发现——无胃物种的启示 Dann, J. B. PDF N/A Evolution of the Jawed Vertebrate (Gnathostomata) Stomach through Gene Repertoire Loss: Findings from Agastric Species
MOZ和HBO1组蛋白乙酰转移酶复合物是NUP98重排急性髓系白血病的分子依赖性和治疗靶点 Michmerhuizen, N. L. PDF N/A MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia
果蝇大脑中已鉴定神经元的突触图谱分析 Wu, H. PDF N/A Synapse profiling of identified neurons in the Drosophila brain
章鱼胺信号协调果蝇蘑菇体中突触前机制的空间模式 Wu, H. PDF N/A Octopamine signals coordinate the spatial pattern of presynaptic machineries in the Drosophila mushroom bodies
高通量定量miRNA-3'-非翻译区调控效应 Mastriano, S. PDF N/A High-Throughput Quantification of miRNA-3'-Untranslated-Region Regulatory Effects
在秀丽隐杆线虫中对Rab GTPase基因进行RNAi筛选发现,生殖系统的体细胞在形态发生过程中依赖于rab-1,但在干细胞龛位的维持中并不依赖于rab-1。 Scott, K. F. PDF N/A An RNAi screen of Rab GTPase genes in C. elegans reveals that somatic cells of the reproductive system depend on rab-1 for morphogenesis but not stem cell niche maintenance
不同的分化轨迹对V2a中间神经元的基因调控和功能产生持久影响。 Elder, N. H. PDF N/A Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a interneurons
立克次氏菌细菌的比较基因组学揭示了与节肢动物共生相互作用中涉及的可变代谢特征 Floriano, A. M. M. PDF N/A Comparative genomics of Rickettsiella bacteria reveal variable metabolic traits involved in symbiotic interactions with arthropods
利用从头设计的蛋白质抑制致病性大肠杆菌的血红素盗取 Fox, D. R. PDF N/A Inhibiting heme-piracy by pathogenic Escherichia coli using de novo-designed proteins
CRISPR-Cas13高效抑制剂的从头设计 Taveneau, C. PDF N/A De novo design of potent CRISPR-Cas13 inhibitors
基于亮氨酸拉链的SAIM成像技术可识别用于破坏癌细胞糖萼以增强免疫治疗的药物 Park, S. PDF N/A Leucine zipper-based SAIM imaging identifies therapeutic agents to disrupt the cancer cell glycocalyx for enhanced immunotherapy
水溶性CD20抗原的设计与计算表位支架构建 Yao, Z. PDF N/A Design of a Water-Soluble CD20 Antigen with Computational Epitope Scaffolding
IP6阴离子结合对HIV-1衣壳组装分子开关的动态影响 Gupta, M. PDF N/A Kinetic Implications of IP6 Anion Binding on the Molecular Switch of the HIV-1 Capsid Assembly
结核分枝杆菌CrgA形成二聚体结构,其跨膜结构域夹在胞质和周质β片层之间,从而能够与多个分裂体蛋白进行多重相互作用。 Shin, Y. PDF N/A Mycobacterium tuberculosis CrgA Forms a Dimeric Structure with Its Transmembrane Domain Sandwiched between Cytoplasmic and Periplasmic β-Sheets, Enabling Multiple Interactions with Other Divisome Proteins
PIP2激活和SEA0400抑制在人类心脏钠钙交换体NCX1中的结构机制 Xue, J. PDF N/A Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1
多尺度建模展示了细胞-细胞外基质相互作用如何影响细胞外基质纤维排列和细胞脱离 Arellano-Tinto, J. PDF N/A Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment
小热休克蛋白客户隔离与诱导多分散性的机制 Miller, A. P. PDF N/A Mechanism of small heat shock protein client sequestration and induced polydispersity
基于微阀的免流梯度发生器 Bohec, P. PDF N/A Microvalve-based devices for flow-free gradient generators
明确分配弯曲的β片层有助于深入理解生物分子凝聚物中可逆性的分子语法 Roy, I. PDF N/A Unambiguous assignment of kinked beta sheets leads to insights into molecular grammar of reversibility in biomolecular condensates
登革病毒非结构5(NS5)与启动子茎环A(SLA)相互作用的结构动力学 Obi, J. O. PDF N/A Structural Dynamics of the Dengue Virus Non-structural 5 (NS5) Interactions with Promoter Stem Loop A (SLA)
CIGB-300在肺鳞状细胞癌蛋白质组学中的时间依赖性和剂量依赖性效应。 Garcia, L. E. PDF N/A Time- and Dose-dependent Effects of CIGB-300 in the lung squamous cell carcinoma proteomics.
膜相关泛素连接酶MARCHF8通过降解MHC I类蛋白促进癌症免疫逃逸 Khalil, M. I. PDF N/A The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins
人类mGlu5变构调节剂的药理学特征 Razzak, M. PDF N/A Pharmacological characterisation of allosteric modulators at human mGlu5
来自乌克兰东部不同R-E半克隆种群系统的Pelophylax水蛙的杂交生殖:选择性死亡率、克隆和倍性多样性 Fedorova, A. PDF N/A Hybridogenetic reproduction of Pelophylax water frogs from different R-E hemiclonal population systems from Eastern Ukraine: selective mortality, clonal and ploidy diversity
在腰果占主导地位的生物多样性热点地区,种植园内及周边森林覆盖的本地树木对鸟类保护至关重要。 Madhu, N. PDF N/A Native trees within plantations and surrounding forest cover are essential for bird conservation in cashew-dominated landscapes within a biodiversity hotspot
伊维菌素在秀丽隐杆线虫(Caenorhabditis elegans)这一线虫模型中的抗性进化:种群大小的重要影响及对依莫德吡的意外交叉抗性 Hellinga, J. PDF N/A Evolution of ivermectin resistance in the nematode model Caenorhabditis elegans: critical influence of population size and unexpected cross-resistance to emodepside
尿道双J导管复杂微生物群落的表型特征及细菌相互作用 Farizano, J. V. PDF N/A PHENOTYPIC CHARACTERIZATION AND BACTERIAL INTERACTIONS OF THE COMPLEX MICROBIAL POPULATION IN URINARY DOUBLE-J CATHETERS
铜绿假单胞菌(Pseudomonas aeruginosa)对血清素、多巴胺、肾上腺素和去甲肾上腺素表现出趋化性。 Monteagudo-Cascales, E. PDF N/A Pseudomonas aeruginosa performs chemotaxis to serotonin, dopamine, epinephrine, and norepinephrine
特定阶段的预运动抑制调节了水蛭的节律性运动输出 Radice, M. PDF N/A Phase-specific premotor inhibition modulates leech rhythmic motor output
糖蛋白pherophorin II的时空分布揭示了Volvox carteri生长中的细胞外基质的随机几何结构 von der Heyde, B. PDF N/A Spatiotemporal distribution of the glycoprotein pherophorin II reveals stochastic geometry of the growing ECM of Volvox carteri
模拟为贝特曼梯度提供了机制性解释。 Sanghvi, K. PDF N/A Simulations provide a mechanistic interpretation of Bateman gradients
从色素到精准:探索小麦和大麦的基因转化与基因组编辑 Prusty, M. R. PDF N/A From Pigments to Precision: Exploring Genetic Transformation and Genome Editing in Wheat and Barley
R-环语法预测了在不同拓扑约束下R-环的形成。 Ferrari, M. M. PDF N/A The R-loop Grammar predicts R-loop formation under different topological constraints
在成年期,目标导向导航的认知和运动能力下降是可分离的,并贯穿整个生命周期。 LAncia, G. L. PDF N/A Separable cognitive and motor decline tracked across adult life-span for goal-directed navigation
利用下一代测序数据的生物信息学分析,鉴定与阿尔茨海默病相关的候选生物标志物和信号通路 Vastrad, B. M. PDF N/A Identification of candidate biomarkers and signaling pathways associated with Alzheimer's disease using bioinformatics analysis of next generation sequencing data
用于从单细胞转录组数据预测样本表型的可解释深度神经网络 Martorell-Marugan, J. PDF N/A Explainable deep neural networks for predicting sample phenotypes from single-cell transcriptomics
GJB3是一种缝隙连接基因,通过介导胱氨酸摄取和调节细胞应激途径,支持SLC7A11低表达的腺癌中的细胞生长。 Acharya, D. PDF N/A GJB3, a gap junction gene, supports cell growth by mediating cystine uptake and regulating cellular stress pathways in SLC7A11 low adenocarcinomas
DeepGraphMut:一种基于图的深度学习方法,利用体细胞突变谱进行癌症预后分析 Jose, A. PDF N/A DeepGraphMut: A graph-based deep learning methodfor cancer prognosis using somatic mutation profile
2024年荷兰蓝舌病毒12型 - 首次在欧洲报告的蓝舌病毒血清型 van den Brom, R. PDF N/A Bluetongue virus serotype 12 in the Netherlands in 2024 - A BTV serotype reported in Europe for the first time
自愿行为能增强感官预测能力,并促进对相关感官刺激的神经处理。 Ody, E. PDF N/A Voluntary action sharpens sensory prediction and facilitates neural processing of contingent sensory stimuli
在自身免疫性脱髓鞘模型中揭示的变节抗体:从生物学到治疗 Taghipour-Mirakmahaleh, R. PDF N/A Turncoat antibodies unmasked in a model of autoimmune demyelination: from biology to therapy
乳酸乳球菌亚种乳脂亚种C60通过功能性修饰树突状细胞,创造了一种以I型调节性T细胞为主导的抗炎肠道环境。 Saito, S. PDF N/A Lactococcus lactis subsp. cremoris C60 creates a type I regulatory T cell-dominant anti-inflammatory intestinal environment through functional modification of dendritic cells
三种Candidatus Liberibacter solanacearum载体(Dyspersa apicalis、Dyspersa pallida和Trioza urticae)的染色体水平组装(半翅目:瘿蚊科) Heaven, T. PDF N/A Chromosome-level Assemblies of Three Candidatus Liberibacter solanacearum Vectors: Dyspersa apicalis, Dyspersa pallida, and Trioza urticae (Hemiptera: Psylloidea)
通过长读长测序进行血红蛋白病变异的综合检测 Xiang, J. PDF N/A The comprehensive detection of hemoglobinopathy variants via long-read sequencing
人类肠道微生物群中两个关键的放线菌门分类群与曼氏血吸虫感染负担相关 Appiah-Twum, F. PDF N/A Two Key Actinomycetota Taxa in the Human Gut Microbiota are Associated with Schistosoma mansoni Infection Burden
电影间的差异性严重限制了“自然主义”神经影像学研究结果的可推广性。 Leipold, S. PDF N/A Between-movie variability severely limits generalizability of "naturalistic" neuroimaging
Dnmt3a介导的新生甲基化平衡了Th1和Tfh记忆细胞的可塑性和功能性。 Perkins, B. PDF N/A Dnmt3a-mediated de novo methylation balances Th1 and Tfh memory cell plasticity and functionality
Tokenvizz:基于GraphRAG的基因组数据发现与可视化标记化工具 Oguztuzun, C. PDF N/A Tokenvizz: GraphRAG-Inspired Tokenization Tool for Genomic Data Discovery and Visualization
同时抑制MDM2和PARP在p53野生型横纹肌肉瘤模型中产生协同抗肿瘤效应 Pons, G. PDF N/A Combined inhibition of MDM2 and PARP lead to a synergistic anti-tumoral response in p53 wild-type rhabdomyosarcoma models
运动可以缓解肝脏衰老,但在饮食诱导的MASLD中,其效果并不优于饮食限制。 Katsarou, A. PDF N/A Exercise alleviates liver senescence but does not outmatch the effect of dietary restriction in diet-induced MASLD
一种用于急性视网膜外植体中光感受器和神经节细胞联合功能评估的方法 He, X. PDF N/A A Method for the Combined Functional Assessment of Photoreceptors and Ganglion Cells in Acute Retinal Explants
紧张性冷痛的神经动力学:对健康个体在扫描仪内冷压测试替代方法的新研究 Medina, S. PDF N/A Neural Dynamics of Tonic Cold Pain: A Novel Investigation of an In-Scanner Alternative to the Cold Pressor Test in Healthy Individuals
空间注意力和特征选择性注意力相互作用,驱动前顶叶皮层的选择性编码 Dermody, N. PDF N/A Spatial and feature-selective attention interact to drive selective coding in frontoparietal cortex
使用CellREADR在人脑皮层中进行RNA可编程的细胞类型监测与操控 Matthews, E. A. PDF N/A RNA-programmable cell type monitoring and manipulation in the human cortex with CellREADR
捕获SARS-CoV-2刺突蛋白融合中间构象需要受体结合以及在S1/S2或S2'位点的切割 Lusvarghi, S. PDF N/A Capture of fusion-intermediate conformations of SARS-CoV-2 spike requires receptor binding and cleavage at either the S1/S2 or S2' site
SARS-CoV-2对高尔基体结合的PI4P的捕食,引发了细胞质中DNA损伤反应激酶ATM的大规模激活。 Rebendenne, A. PDF N/A SARS-CoV-2 predation of Golgi-bound PI4P primes the massive activation of the DNA Damage Response kinase ATM in the cytoplasm
高效地利用CUT&RUN技术进行染色质相关靶点的基因组定位 Firestone, T. M. PDF N/A High-efficiency genomic mapping of chromatin-associated targets with CUT&RUN
滞留短新生链测序揭示了布氏锥虫中真核DNA复制起源的拓扑结构。 STANOJCIC, S. PDF N/A Stranded short nascent strand sequencing reveals the topology of eukaryotic DNA replication origins in Trypanosoma brucei.
发育程序推动细胞可塑性、疾病进展和肺腺癌中的治疗抵抗 Bienkowska, K. J. PDF N/A Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
白血病细胞内在和外在因素相互协作,促进了KMT2A重排的B-ALL在中枢神经系统(CNS)微环境中的生存和增殖。 Duguid, A. PDF N/A Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche.
IGFs调控前列腺癌中的癌细胞免疫逃逸 Nandakumar, A. M. PDF N/A IGFs regulate cancer cell immune evasion in prostate cancer
转用电子烟可恢复吸烟小鼠对屋尘螨的免疫反应。 Warren, K. J. PDF N/A Transitioning to e-cigarettes restores the immune response to house dust mite in cigarette smoked mice.
一个用于探索海草生态系统中细菌-病毒动力学的基因组资源 Ettinger, C. L. PDF N/A A genomic resource for exploring bacterial-viral dynamics in seagrass ecosystems
化学基因组学揭示了鲍曼不动杆菌中抗生素和必需基因的功能 Tran, J. S. PDF N/A Chemical genomics informs antibiotic and essential gene function in Acinetobacter baumannii
宏基因组挖掘揭示了双链DNA病毒中的新型病毒组蛋白 Liu, Y. PDF N/A Metagenomic mining reveals novel viral histones in dsDNA viruses
使用声波液体处理器的两步扩增子PCR效率提升 Benz, B. R. PDF N/A Improved Efficiency of Two-Step Amplicon PCR Using an Acoustic Liquid Handler
体内检测未接受治疗和接受抗逆转录病毒治疗(ART)的HIV-1反义转录本 Capoferri, A. A. PDF N/A In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals
EV-D68感染期间诱导的线粒体自噬体促进病毒的非裂解性释放 Jassey, A. PDF N/A Mitophagosomes induced during EV-D68 infection promote viral nonlytic release
滴灌通过重塑水稻根际微生物群落来抑制甲烷排放。 Lau, K. J. X. PDF N/A Drip irrigation suppresses methane emissions by reshaping the rhizosphere microbiomes in rice
利用放线菌的生物合成多样性:通过比较基因组和代谢分析发现独特的天然产物 Kikuchi, Y. PDF N/A Harnessing the Biosynthetic Diversity of Actinomycetes: Discovery of Unique Natural Products through Comparative Genomic and Metabolic Analysis
通过综合蛋白质组学方法探索病毒与宿主相互作用,发现BANF1是非洲猪瘟病毒的新关键因子。 Dupre, J. PDF N/A Exploring virus-host interactions through combined proteomic approaches identifies BANF1 as a new essential factor for African Swine Fever Virus.
LEDGF/p75介导的整合中断会解除对HIV-1基因组反义转录的抑制 Tedbury, P. R. PDF N/A Disruption of LEDGF/p75-directed integration derepresses antisensetranscription of the HIV-1 genome
泛素样蛋白(UBLs)的蛋白质和小分子底物的全局分析 Shao, G. PDF N/A Global analysis of protein and small-molecule substrates of ubiquitin-like proteins (UBLs)
利用工程细胞分裂素调节剂可预测地调控植物根系发育 Rattan, R. PDF N/A Predictable modulation of plant root development using engineered cytokinin regulators
用于工程合成基因组模块和染色体的迭代SCRaMbLE Lu, X. PDF N/A Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes
Vgamma1+ γδ T细胞衍生的IL-4启动CD8 T细胞免疫 Le, S. PDF N/A Vgamma1+ gammadelta T cell-derived IL-4 initiates CD8 T cell immunity
来得容易,去得更快:绘制整个生命树中鞭毛运动能力的丧失图谱 Philip, J. S. PDF N/A Easy come, easier go: mapping the loss of flagellar motility across the tree of life
培养及分子表征孕妇分娩前留置导尿管尿液、清洁中段尿及阴道拭子 Greenberg, J. M. PDF N/A Cultivation and molecular characterization of Foley catheterized urine, clean catch urine, and vaginal swabs from pregnant women prior to delivery
原生动物种群驱动瘤胃微生物组的系统性变异 Kobel, C. M. PDF N/A Protozoal populations drive system-wide variation in the rumen microbiome
肝素酶,一种强效抑制逆转录病毒转录的宿主基因 Waxman, B. PDF N/A Heparanase, a host gene that potently restricts retrovirus transcription
人类中siRNAs介导的基因沉默的结构基础 Sarkar, S. PDF N/A Structural basis for gene silencing by siRNAs in humans
Chd1的CHCT结构域与Rtf1之间的直接相互作用控制着Chd1在活性基因上的分布以及核小体的定位。 Tripplehorn, S. A. PDF N/A A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes
RNA介导的MYC多聚化抑制先天免疫信号传导 Uhl, L. PDF N/A RNA-mediated MYC multimerization suppresses innate immune signaling
资源防御在促进性选择武器进化中的作用:一项实验进化测试 Audet, T. PDF N/A The role of resource defensibility in facilitating sexually-selected weapon evolution: An experimental evolution test
印度不同地理区域埃及伊蚊种群中电压门控钠通道(VGSC)基因IIS6结构域的遗传多样性 Sumitha, M. K. PDF N/A Genetic diversity in the IIS6 domain of Voltage Gated Sodium Channel (VGSC) gene among Aedes aegypti populations from different geographical regions in India
人类肠道微生物组中氨基酸脱羧酶酶的多样性与普遍性——一项生物信息学研究 Sandoval, M. PDF N/A Diversity and prevalence of amino acid decarboxylase enzymes in the human gut microbiome -- a bioinformatics investigation
对库蠓属蚊虫(Culicoides sonorensis)进行的实验性BTV-3和BTV-8病毒感染 Zeiske, S. PDF N/A Experimental BTV-3 and BTV-8 infection of Culicoides sonorensis biting midges
酵母中依赖RNA的蛋白质的普查 Waber, N. B. PDF N/A A census of RNA-dependent proteins in yeast
评估用于归巢抑制基因驱动的目标基因 Xu, X. PDF N/A Assessing target genes for homing suppression gene drive
研究同多聚体儿茶酚1,2-双加氧酶的四级结构:一项综合结构生物学研究。 Almeida-Juarez, A. G. PDF N/A Investigating the quaternary structure of a homomultimeric catechol 1,2-dioxygenase: An integrative structural biology study.
通用节奏架构揭示了不同的神经动力学模式 K, G. PDF N/A Universal rhythmic architecture uncovers distinct modes of neural dynamics
振荡爆发特征与人类工作记忆期间偏差之间的关联 Kavanaugh, B. PDF N/A The association between oscillatory burst features and deviations during human working memory
意志调节与中脑振荡的可转移模式 Lu, H.-Y. PDF N/A Volitional Regulation and Transferable Patterns of Midbrain Oscillations
人类海马体在导航和心理模拟过程中低频振荡的异同 Seger, S. PDF N/A Differences and similarities between human hippocampal low-frequency oscillations during navigation and mental simulation
成年视觉剥夺会引发与丘脑皮质输入相关的突触前可塑性 Murase, S. PDF N/A Adult visual deprivation engages associative, presynaptic plasticity of thalamic input to cortex
在使用Cntnap2基因敲除的自闭症大鼠模型进行语音辨别任务时,使用预测提示 Centanni, T. M. PDF N/A Use of a predictor cue during a speech sound discrimination task in a Cntnap2 knockout rat model of autism
诚然夸张:吼猴的咆哮声是体型大小的可靠信号,并且对听者具有行为上的相关性。 Dunn, J. C. PDF N/A Honestly exaggerated: howler monkey roars are reliable signals of body size and behaviourally relevant to listeners
早产儿出生后,大脑发育呈现出异质性、时间一致性和可塑性。 Thalhammer, M. PDF N/A Heterogeneous, temporally consistent, and plastic brain development after preterm birth
观察言语:先天性聋和听力正常者在提示性言语感知中的神经机制 Sarre, A. PDF N/A Seeing speech: neural mechanisms of cued speech perception in prelingually deaf and hearing users
在认知控制下,大脑会根据需要选择性地将能量分配给功能性脑网络。 Saberi, M. PDF N/A The brain selectively allocates energy to functional brain networks under cognitive control

medRxiv

标题 作者 PDF链接 代码仓库 Title
初级保健咨询所需时间:利用综合儿童疾病管理(IMCI)临床算法,对低收入和中等收入国家首次患病儿童就诊预期持续时间的估计 Carter, A. T. PDF N/A The Time Required for Primary Care Consultations: Estimates of the Expected Duration of Initial Sick Child Visits in Low- and Middle-income Countries Using the Integrated Management of Childhood Illness (IMCI) Clinical Algorithm
与原发性震颤多基因风险相关的脑成像表型 Medeiros, M. PDF N/A Brain Imaging Phenotypes Associated With Polygenic Risk For Essential Tremor
评估继续治疗妊娠期高血压和甲状腺功能减退对母亲及其后代益处和风险的观察性队列研究:基于英国临床实践研究数据库的研究 Barry, C.-J. S. PDF N/A Assessing the benefits and risks to mothers and offspring of continuing treatment for maternal hypertension and hypothyroidism: an observational cohort study in the UK Clinical Practice Research Datalink
利用硬膜外脑机接口在完全脊髓损伤后恢复手部功能 Liu, D. PDF N/A Reclaiming Hand Functions after Complete Spinal Cord Injury with Epidural Brain-Computer Interface
沟通建模的视觉偏好研究:Covid-19政策与决策者的视角 Hadley, L. PDF N/A Visual preferences for communicating modelling: a study of Covid-19 policy and decision makers
如何在控制性机械通气过程中最小化机械功 Fabry, B. PDF N/A How to minimize mechanical power during controlled mechanical ventilation
原发性中枢神经系统淋巴瘤肿瘤活检显示基因表达谱、遗传亚型及对激酶抑制剂的体外药物敏感性存在异质性。 Zhu, Y. X. PDF N/A Primary Central Nervous System Lymphoma Tumor Biopsies Show Heterogeneity in Gene Expression Profiles, Genetic Subtypes, and in vitro Drug Sensitivity to Kinase Inhibitors
先进的迁移学习方法用于多类皮肤病识别,结合LIME可解释AI技术 Mahmud, M. Z. PDF N/A Advance Transfer Learning Approach for Identification of Multiclass Skin Disease with LIME Explainable AI Technique
监测前往高海拔地区女性的性激素水平 - 一项试点研究 Taalaibekova, A. PDF N/A Monitoring sexual hormones in women going to high altitude - a pilot study
使用人工智能进行髋膝关节置换的风险分层:一项双中心研究,以支持高容量低复杂度中心和日间手术中心的实用性。 Woodward, C. PDF N/A Risk stratification in hip and knee replacement using Artificial Intelligence: a dual centre study to support the utility of high-volume low-complexity hubs and ambulatory surgery centres.
阿尔茨海默病测序项目第4版全基因组测序数据集 Leung, Y. Y. PDF N/A Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset
利用机器学习方法探索儿童和青少年COVID-19的临床特征 Fiandrino, S. PDF N/A Exploring clinical characteristics of COVID-19 in children and adolescents using a machine-learning approach
利用基因组流行病学和地理活动空间研究博茨瓦纳的结核病暴发 Baker, C. R. PDF N/A Using genomic epidemiology and geographic activity spaces to investigate tuberculosis outbreaks in Botswana
开发一种新型转录组衰老测量方法:转录组死亡风险年龄(TraMA) Klopack, E. T. PDF N/A Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA)
队列数据流行病学分析的透明性——以挪威母亲、父亲和儿童队列研究(MoBa)为例 Roettger, T. B. PDF N/A Transparency in epidemiological analyses of cohort data - A case study of the Norwegian Mother, Father, and Child cohort study (MoBa)
虚拟访问与艾滋病毒感染者健康结果之间的关联:一项横断面研究 Rehman, N. PDF N/A Association between virtual visits and health outcomes of people living with HIV: A cross-sectional study
唑尼沙胺的现实世界安全性:基于FAERS数据库的唑尼沙胺相关不良事件挖掘与分析 Zhang, Y. PDF N/A Real-world safety of zonisamide: Mining and analysis of adverse events related to zonisamide based on FAERS database
精神障碍的终生患病率及发病年龄,以及12个月内在初级和二级护理中的服务利用情况:一项芬兰全国性登记研究 Suokas, K. PDF N/A Lifetime incidence and age of onset of mental disorders, and 12-month service utilization in primary and secondary care: a Finnish nationwide registry study
从肠道到大脑:肠道微生物群对人类重度抑郁症有因果贡献的证据 Fehse, L. PDF N/A From Gut to Brain: Evidence for a Causal Contribution of Gut-Microbiota to Major Depressive Disorder in Humans
隐形追踪:全球关于6个月以下脆弱婴儿及其母亲护理政策指南的综述 McGrath, M. PDF N/A Invisible pursuit: A scoping review of global policy guidance on care of vulnerable infants under 6 months and their mothers
振动刺激而非动作观察或镜像疗法可降低慢性中风幸存者瘫痪手的痉挛性。 Nakano, H. PDF N/A Vibratory stimulation and not action observation or mirror therapy reduces paralyzed hand spasticity in chronic stroke survivors
纹状体是使用PiB在唐氏综合症中早期、准确指示淀粉样蛋白负担的指标:两种放射性示踪剂的比较 McLachlan, M. PDF N/A The striatum is an early, accurate indicator of amyloid burden using PiB in Down syndrome: comparison of two radiotracers
评估健康志愿者中三种单次递增剂量二胺氧化酶(DAO)的安全性和耐受性 Molina Perello, P. PDF N/A Evaluation of the safety and tolerability of three single ascending doses of Diamine oxidase (DAO) in healthy volunteers
咨询有助于制定策略,以提高在变异分类中功能证据的利用 Villani, R. M. PDF N/A Consultation informs strategies to improve functional evidence use in variant classification
埃塞俄比亚南部沃莱塔和哈迪亚地区儿童看护者中人类免疫缺陷病毒阳性儿童的披露状况及相关因素。 Tesfaye, L. PDF N/A Pediatric human immunodeficiency virus-positive disclosure status and associated factors among caregivers of children in Wolaita and Hadiya zone, southern Ethiopia.
COVID-19大流行对医院抗生素使用和耐药性的影响:基于2019-2022年法国国家监测数据的一项回顾性生态学分析 Layan, M. PDF N/A Impacts of the COVID-19 pandemic on antibiotic use and resistance in hospitals: a retrospective ecological analysis of French national surveillance data over 2019-2022
鼓室内皮质类固醇注射:当前数据情况的评估 Schmidt, S. PDF N/A Intratympanic cortisone injection: an evaluation of the current data situation
高脂血症及溶酶体吞噬相关基因PLAUR、IVNS1ABP和QKI在急性心肌梗死中的诊断价值 Zou, J.-h. PDF N/A The diagnostic value of hyperlipidemia and lipophagy-related genes, PLAUR, IVNS1ABP, and QKI, in acute myocardial infarction
在冠状动脉疾病诊断模式中整合非侵入性、无对比剂及低辐射参数 GUL, I. PDF N/A INCORPORATION OF NON-INVASIVE, CONTRAST-FREE, AND MINIMAL RADIATION PARAMETERS IN THE DIAGNOSTIC MODALITIES OF CORONARY ARTERY DISEASE
美国25岁及以上心力衰竭患者心脏骤停趋势:基于CDC WONDER数据库的见解 Muhammad, A. N. PDF N/A Trends in Cardiac Arrest Among Heart Failure Patients Aged 25 and Older in the United States: Insights from the CDC WONDER Database
通过基因组分析和机器学习模型预测冠状动脉疾病严重程度:遗传SYNTAX评分(GESS)试验 Chatzopoulou, F. PDF N/A Predicting coronary artery disease severity through genomic profiling and machine learning modelling: The GEnetic SYNTAX Score (GESS) trial
共同设计并实施退伍军人事务急诊部门的即时超声项目开发与执行 Theophanous, R. G. PDF N/A Co-designed point-of-care ultrasound program development and implementation at a Veterans Affairs Emergency Department
整合全基因组和转录组测序以表征异构体变异的遗传结构及其对健康和疾病的影响 Liu, C. PDF N/A Integrating Whole Genome and Transcriptome Sequencing to Characterize the Genetic Architecture of Isoform Variation and its Implications for Health and Disease
大型综合医疗系统中肌痛性脑脊髓炎/慢性疲劳综合征样疾病的诊断不足——北加州凯撒医疗集团,2022-2023年 Wood, M. PDF N/A Underdiagnosis of myalgic encephalomyelitis/chronic fatigue syndrome-like illness in a large integrated healthcare system -- Kaiser Permanente Northern California, 2022-2023
在巴西圣保罗西北部发生大规模基孔肯雅热疫情期间的昆虫学监测:来自圣若泽杜里奥普雷图的见解 Banho, C. A. PDF N/A Entomological surveillance during a major CHIKV outbreak in northwestern Sao Paulo: insights from Sao Jose do Rio Preto
结构、行为和症状预测因子对rs10866912风险等位基因频率的影响 Forthman, K. L. PDF N/A Structural, Behavioral, and Symptomatic Predictors of Risk Allele Frequency at rs10866912
越南胡志明市不稳定住房人群中的严重心理困扰:患病率及关联因素 MURAKAMI, H. PDF N/A Serious psychological distress among people with unstable housing in Ho Chi Minh City, Vietnam: Prevalence and associated factors
从社区作为数据提供者到社区作为数据使用者:在肯尼亚的艾滋病/性传播感染项目科学中,利用项目数据开发社区主导的研究平台 Tahmo, N. PDF N/A From community as data providers to community as data users: developing a community-led research platform using program data in HIV/STI Program Science in Kenya
女性夜班工作者患哮喘的风险增加 Maidstone, R. J. PDF N/A Increased risk of asthma in female night shift workers
阿托伐他汀作为慢性阻塞性肺疾病辅助治疗的疗效和安全性:系统评价与Meta分析 Chen, K. PDF N/A Efficacy and Safety of Atorvastatin as Adjunctive Treatment in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
血清雄激素与性激素结合球蛋白的整合用于优化侵袭性前列腺癌的早期检测 Lazareva, O. PDF N/A Integration of serum androgens and Sex Hormone-Binding Globulin for optimized early detection of aggressive prostate cancer
印度初级保健中心用于痴呆检测的认知筛查工具:范围综述 R, J. G. PDF N/A Cognitive Screening Tools for Dementia Detection in Primary Healthcare Centres in India: A Scoping Review
德黑兰心血管医院碳青霉烯类药物管理计划及文献综述 Nazari, E. PDF N/A Carbapenem Stewardship Program in a Cardiovascular Hospital in Tehran, Iran and Literature Review
喀麦隆医护人员血液及其他体液的职业暴露:系统综述与荟萃分析 Cheuyem, F. Z. L. PDF N/A Occupational Exposures to Blood and other Body Fluids among Healthcare Workers in Cameroon: A Systematic Review and Meta-analysis
COVID-19疫苗支付意愿及其相关因素:孟加拉国横断面调查 Hossain, M. B. PDF N/A Willingness to pay for COVID-19 vaccine and its correlates: A cross-sectional survey in Bangladesh
基于人工智能的临床决策支持系统中的风险与不确定性沟通:范围综述 Gray, N. PDF N/A Risk and Uncertainty Communication in Deployed AI-based Clinical Decision Support Systems: A scoping review
2000年至2021年英国头颈部癌症的发病率、患病率和生存率 Miquel Dominguez, A. PDF N/A Incidence, prevalence, and survival of head and neck cancers in the United Kingdom from 2000-2021
活减毒流感疫苗与灭活流感疫苗在儿童中的实际效果比较 Rigamonti, V. PDF N/A Real-World Effectiveness of Live Attenuated vs. Inactivated Influenza Vaccines in Children