| 基于逻辑的糖尿病肾病中炎症性巨噬细胞与肾小球内皮细胞相互作用的建模 |
Patidar, K. |
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N/A |
Logic-Based Modeling of Inflammatory Macrophage Crosstalk with Glomerular Endothelial Cells in Diabetic Kidney Disease |
| 皮质微电路中不确定性感知的预测误差 |
Wilmes, K. A. |
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N/A |
Uncertainty-modulated prediction errors in cortical microcircuits |
| 丹尼索瓦人、尼安德特人和现代人类中的MUC19基因：反复基因渗入与自然选择的进化历程 |
Villanea, F. A. |
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N/A |
The MUC19 gene in Denisovans, Neanderthals, and Modern Humans: An Evolutionary History of Recurrent Introgression and Natural Selection |
| 暴食通过调节嗅觉风味表征来促进食欲 |
Lo, H. |
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N/A |
Binge Feeding Promotes Appetite via Modulating Olfactory Flavor Representation |
| 细菌肌动蛋白同源物家族形成了一个三股螺旋管状结构。 |
Bergeron, J. |
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N/A |
A family of bacterial actin homologues forms a 3-stranded tubular structure |
| 自适应编码解释了阿尔茨海默病、自闭症谱系障碍和创伤后应激障碍中，海马体大小与记忆功能之间看似矛盾的关系。 |
Stocco, A. |
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N/A |
Adaptive Coding Explains the Paradoxical Relationship between hippocampus size and memory function in Alzheimer's Disease, Autism Spectrum Disorder, and PTSD |
| 量化分层肌肉相互作用对运动功能的多样化贡献 |
O'Reilly, D. |
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N/A |
Quantifying the diverse contributions of hierarchical muscle interactions to motor function |
| ganon2：最新且可扩展的宏基因组分析工具 |
Piro, V. C. |
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N/A |
ganon2: up-to-date and scalable metagenomics analysis |
| 基于记忆的偏好的主动构建与被动响应 |
Nicholas, J. |
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N/A |
Proactive and reactive construction of memory-based preferences |
| 在贝叶斯推理过程中，随着信念精度的提高，神经变异性会逐渐压缩。 |
Skowron, A. |
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N/A |
Neural variability compresses with increasing belief precision during Bayesian inference |
| 深海热液虾Rimicaris exoculata基因表达的潮汐调控 |
Zhang, H. |
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N/A |
Circatidal control of gene expression in the deep-sea hot vent shrimp Rimicaris leurokolos |
| 通过学习生成来掌握细胞语言 |
Chen, Y. |
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N/A |
Toward mastering the cell language by learning to generate |
| 通过胶质细胞转分化实现成年神经发生的中枢神经系统损伤范式 |
Casas-Tinto, S. |
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N/A |
Adult Neurogenesis through Glial Transdifferentiation in a CNS Injury Paradigm |
| 感觉输入匹配视觉工作记忆引导内部优先级 |
Koevoet, D. |
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N/A |
Sensory Input Matching Visual Working Memory Guides Internal Prioritization |
| K2R：用于从测序数据集中高效提取读取的着色德布鲁因图实现 |
Vandamme, L. |
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N/A |
K2R: Tinted de Bruijn Graphs implementation for efficient read extraction from sequencing datasets |
| 标准设定对意识神经测量的建构效度构成了威胁。 |
Fahrenfort, J. J. |
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N/A |
Criterion placement threatens the construct validity of neural measures of consciousness |
| 一项全基因组关联研究指出，果蝇（Drosophila melanogaster）的滞育相关寿命延长和繁殖力与嗅觉系统有关。 |
Easwaran, S. |
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N/A |
A genome-wide association study implicates the olfactory system in Drosophila melanogaster diapause-associated lifespan extension and fecundity |
| 葡萄藤感染Shiraz病后，病毒多样性及韧皮部转录变化的研究 |
Onetto, C. A. |
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N/A |
Viral diversity and phloem transcriptional changes in Grapevine Shiraz disease infected vines |
| 利用多细胞模拟识别上皮单层屈曲的竞争机制 |
Brown, P. J. |
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N/A |
Competing mechanisms for the buckling of an epithelial monolayer identified using multicellular simulation |
| 功能冗余和非肌动蛋白依赖的定位在酵母Saccharomyces cerevisiae中的原肌球蛋白同工型 |
Dhar, A. |
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N/A |
Functional redundancy and formin-independent localization of tropomyosin isoforms in Saccharomyces cerevisiae |
| 组蛋白是受细胞应激调控的外泌体膜蛋白。 |
Singh, B. |
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N/A |
Histones are exosome membrane proteins regulated by cell stress |
| 一个综合的单核和空间转录组图谱揭示了人类海马体的分子景观 |
Thompson, J. R. |
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N/A |
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus |
| 在小鼠模型中实现人工假肢 |
Hayatou, Z. |
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N/A |
Embodiment of an artificial limb in the mouse model |
| 通过提高高粱和甘蔗中Rubisco含量，适应大气变化并增加C4光合作用的生产力 |
Salesse-Smith, C. E. |
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N/A |
Adapting C4 photosynthesis to atmospheric change and increasing productivity by elevating Rubisco content in Sorghum and Sugarcane |
| 宿主编码的DNA甲基转移酶能够修饰侵入噬菌体的表观基因组和宿主特异性。 |
Takahashi, M. |
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N/A |
Host-encoded DNA methyltransferases modify the epigenome and host tropism of invading phages |
| PROTAC诱导的蛋白质结构动力学在靶向蛋白质降解中的作用 |
Wu, K. Y. |
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N/A |
PROTAC-induced Protein Structural Dynamics in Targeted Protein Degradation |
| 瞬时域间相互作用调节Huntingtin外显子1的单体结构集合及其自组装 |
Mohanty, P. |
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N/A |
Transient interdomain interactions modulate the monomeric structural ensemble and self-assembly of Huntingtin Exon 1 |
| 两个分离的世界：论生命科学与生物医学研究中的影响力偏好 |
Gu, Z. |
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N/A |
Two Separated Worlds: on the Preference of Influence in Life Science and Biomedical Research |
| 金盏花：一个基于机器学习的斑马鱼姿态追踪网络应用 |
Teicher, G. |
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N/A |
Marigold: A machine learning-based web app for zebrafish pose tracking |
| 凝胶中荧光蛋白的直接观察：免疫印迹的快速、成本效益高且定量的替代方法 |
Sanial, M. |
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N/A |
Direct observation of fluorescent proteins in gels: a rapid, cost-efficient and quantitative alternative to immunoblotting |
| 生物入侵过程中与适应性进化相关的花期表型特征的纬度渐变 |
Akbar, M. |
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N/A |
Latitudinal clines in the phenology of floral display associated with adaptive evolution during a biological invasion |
| 通过PHORCE揭示了噬菌体扩增速率的极端多样性以及噬菌体与抗生素相互作用的复杂性。 |
Mulla, Y. |
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N/A |
Extreme diversity of phage amplification rates and phage-antibiotic interactions revealed by PHORCE |
| Syntaxin-2 协调内溶酶体运输，以平衡巨噬细胞中的吞噬摄取和吞噬溶酶体清除。 |
Samanta, S. |
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N/A |
Syntaxin-2 coordinates endolysosomal trafficking to balance phagocytic uptake and phagolysosomal clearance in macrophages |
| 全球海洋中硅藻多样性和丰度的模式与驱动因素 |
Pierella Karlusich, J. J. |
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N/A |
Patterns and drivers of diatom diversity and abundance in the global ocean |
| 山兔（Lepus timidus）染色体水平参考基因组组装 |
Fekete, Z. |
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N/A |
Chromosome-level reference genome assembly for the mountain hare (Lepus timidus) |
| 微生物群落在进行水平基因转移时出现替代稳定状态 |
Hong, J. |
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N/A |
Emergence of alternative stable states in microbial communities undergoing horizontal gene transfer |
| 表征漂移作为持续记忆存储的结果 |
Devalle, F. |
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N/A |
Representational drift as the consequence of ongoing memory storage |
| 使用高度多样化的条形码库定量小鼠感染中鼠伤寒沙门氏菌种群动力学 |
Hotinger, J. A. |
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N/A |
Quantification of Salmonella enterica serovar Typhimurium Population Dynamics in Murine Infection Using a Highly Diverse Barcoded Library |
| 气候变化下地方性种群的爆发性昆虫暴发 |
Brush, M. |
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N/A |
Eruptive insect outbreaks from endemic populations under climate change |
| 学习进度表与教学的共同演化，不仅促进了知识的累积，还催生了一种教师创新综合症。 |
Maisonneuve, L. |
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N/A |
The coevolution of learning schedules and teaching enhances cumulative knowledge and drives a teacher-innovator syndrome |
| CrypToth：通过混合溶剂分子动力学模拟和拓扑数据分析进行隐秘口袋检测 |
Koseki, J. |
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N/A |
CrypToth: Cryptic pocket detection through mixed-solvent molecular dynamics simulations based topological data analysis |
| 艰难梭菌的定植并非由胆盐介导，而是在体外模型中利用了脯氨酸的斯蒂克兰发酵作用。 |
Huang, X. |
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N/A |
Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model |
| TwinEco：生态学中动态数据驱动数字孪生的统一框架 |
Khan, T. |
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N/A |
TwinEco: A Unified Framework for Dynamic Data-Driven Digital Twins in Ecology |
| 章鱼可以利用气味烟羽来寻找食物。 |
Weertman, W. L. |
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N/A |
Octopus can use odor plumes to find food |
| 多效性在从现有遗传变异适应过程中增强了并行选择特征 |
Lai, W.-Y. |
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N/A |
Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation |
| 葡萄糖激酶活性调控位于外周的β细胞亚群，这些细胞主导胰岛钙离子振荡。 |
Jin, E. |
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N/A |
Glucokinase activity controls peripherally-located subpopulations of β-cells that lead islet Ca2+ oscillations |
| 通过转录凝聚体对基因的急性激活影响染色质域中的非目标基因 |
Bohra, D. |
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N/A |
Acute Activation of Genes Through Transcriptional Condensates Impact Non-target Genes in a Chromatin Domain |
| 通过实验进化揭示果蝇攻击性的进化反馈 |
Girardeau, A. R. |
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N/A |
Evolutionary feedbacks for Drosophila aggression revealed through experimental evolution |
| 斑马鱼视觉系统中对猎物刺激的双眼整合 |
Tian, G. |
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N/A |
Binocular integration of prey stimuli in the zebrafish visual system |
| 对拟南芥中影响叶片毛状体发育和表皮金属积累的基因进行全基因组关联筛选 |
Bezvoda, R. |
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N/A |
A genome-wide association screen for genes affecting leaf trichome development and epidermal metal accumulation in Arabidopsis |
| 管道奥运会：针对DNA甲基化测序数据计算工作流程的可续性基准测试，以实验金标准为对照 |
Lin, Y.-Y. |
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N/A |
Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold-standard |
| 哺乳动物视网膜双极细胞：兔视网膜形态学鉴定与系统分类，并附比较视角 |
Famiglietti, E. V. |
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N/A |
Mammalian Retinal Bipolar Cells: Morphological Identification and Systematic Classification in Rabbit Retina, with a Comparative Perspective |
| 丰度测量揭示了人类肠道微生物群中裂解与溶原之间的平衡。 |
Lopez, J. A. |
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N/A |
Abundance measurements reveal the balance between lysis and lysogeny in the human gut microbiome |
| LongTrack：基于长读长宏基因组学的粪便微生物群移植后细菌菌株及其基因组变化的精准追踪 |
Fan, Y. |
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N/A |
LongTrack: long read metagenomics-based precise tracking of bacterial strains and their genomic changes after fecal microbiota transplantation |
| 使用单细胞和单核测序技术进行可扩展电路图谱绘制的高复杂度条码狂犬病病毒 |
Shin, D. |
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N/A |
High-Complexity Barcoded Rabies Virus for Scalable Circuit Mapping Using Single-Cell and Single-Nucleus Sequencing |
| 光化学分析突触和突触外NMDA受体分子多样性 |
Sicard, A. |
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N/A |
Optochemical profiling of NMDA receptor molecular diversity at synaptic and extrasynaptic sites |
| 通过通信子空间在大规模新皮层模型中进行认知网络交互 |
Pereira-Obilinovic, U. |
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N/A |
Cognitive network interactions through communication subspaces in large-scale models of the neocortex |
| 纹状体胆碱能中间神经元的同步激活引发局部血清素释放。 |
Matityahu, L. |
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N/A |
Synchronous activation of striatal cholinergic interneurons induces local serotonin release |
| AnnSQL：一个基于Python SQL的包，用于在笔记本电脑上进行大规模单细胞基因组学分析 |
Pavan, K. |
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N/A |
AnnSQL: A Python SQL-based package for large-scale single-cell genomics analysis on a laptop |
| 资源环境塑造了人类阴道微生物群的组成和稳定性。 |
Kamiya, T. |
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N/A |
Resource landscape shapes the composition and stability of the human vaginal microbiota |
| 大肠杆菌K12中tRNA修饰缺陷的协同效应。 |
Bacusmo, J. M. |
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N/A |
Synergistic effects of tRNA modification defects in Escherichia coli K12. |
| 通过成像质谱流式技术对细胞外基质进行表型分析，揭示了与过敏性气道炎症相关的不同细胞外基质环境。 |
Parkinson, J. E. |
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N/A |
Extracellular matrix phenotyping by imaging mass cytometry defines distinct cellular matrix environments associated with allergic airway inflammation. |
| 通过机器学习分析免疫单细胞RNA测序数据，揭示免疫检查点疗法反应的预测基因和细胞特征 |
Pinhasi, A. |
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N/A |
Uncovering Predictive Gene and Cellular Signatures for Checkpoint Immunotherapy Response through Machine Learning Analysis of Immune Single-Cell RNA-seq Data |
| 有害突变可能有助于性染色体之间重组抑制的进化。 |
Jay, P. |
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N/A |
Deleterious mutations can contribute to the evolution of recombination suppression between sex chromosomes |
| 老年对黑猩猩使用石器工具的参与度和效率的影响是多变的。 |
Howard-Spink, E. |
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N/A |
Old age variably impacts chimpanzee engagement and efficiency in stone tool use |
| 肽胶束递送以在细胞内形成稳定的相互作用枢纽 |
Tu, W. |
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N/A |
Delivery of Peptide Coacervates to Form Stable Interaction Hubs In Cells |
| 人类诱导多能干细胞（iPSCs）中染色体12三体性激增的起源 |
Narozna, M. |
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N/A |
Origin of Chromosome 12 Trisomy Surge in Human Induced Pluripotent Stem Cells (iPSCs) |
| 使用12-6 Lennard-Jones势能模型模拟银(I)离子与蛋白质的相互作用：一种自下而上的参数化方法 |
Manciocchi, L. |
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N/A |
Modelling the interaction between silver(I) ion and proteins with the 12-6 Lennard-Jones potential: a bottom-up parameterization approach |
| 癌基因SLC35F2是一种高特异性的转运蛋白，专门负责转运微量营养素喹啉和喹喔啉。 |
Burtnyak, L. |
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N/A |
The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine |
| 多尺度建模展示了细胞-细胞外基质（ECM）相互作用如何影响ECM纤维排列和细胞脱离。 |
Arellano-Tinto, J. |
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N/A |
Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment |
| 自愿行动能够增强感官预测，并促进对相关感官刺激的神经处理。 |
Ody, E. |
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N/A |
Voluntary action sharpens sensory prediction and facilitates neural processing of contingent sensory stimuli |
| CECR2溴结构域展现出对乙酰化组蛋白与非组蛋白配体不同的结合模式。 |
Phillips, M. |
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N/A |
The CECR2 bromodomain displays distinct binding modes to select for acetylated histone proteins versus non-histone ligands. |
| 利用计算工具来理解雷公藤内酯-XPB相互作用 |
Gorrie, D. |
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N/A |
Leveraging computational tools to understand the triptolide-XPB interaction |
| 膜焦磷酸酶对H+运输的快速动力学：直接耦合机制的证据 |
Anashkin, V. A. |
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N/A |
Rapid kinetics of H+ transport by membrane pyrophosphatase: evidence for a direct-coupling mechanism |
| DiscoEPG：一个用于昆虫电穿透图（EPG）信号特征分析的Python包 |
Dinh, Q. D. |
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N/A |
DiscoEPG: A Python package for characterization of insect electrical penetration graph (EPG) signals |
| 一个关于多稳态的决策理论模型：感知转换作为内部行动 |
Safavi, S. |
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N/A |
A decision-theoretic model of multistability: perceptual switches as internal actions |
| SegCSR：基于脑带分段实现皮质表面重建的弱监督方法 |
Zheng, H. |
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N/A |
SegCSR: Weakly-Supervised Cortical Surfaces Reconstruction from Brain Ribbon Segmentations |
| 抗肥胖化合物，司美格鲁肽和利拉鲁肽，不会改变人类和小鼠POMC+神经元的比例。 |
Jörgensen, S. K. M. |
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N/A |
Anti-obesity compounds, Semaglutide and LiPR, do not change the proportion of human and mouse POMC+ neurons |
| 在回文性风湿病中滑膜炎发作的棘轮模型 |
Chakraborty, S. |
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N/A |
The Ratchet Model of Synovial Flares in Palindromic Rheumatism |
| N1-甲基假尿苷mRNA修饰通过防止Prkra介导的全局翻译抑制，增强了基因过表达的效率和特异性。 |
Lu, T. |
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N/A |
N1-methylpseudouridine mRNA modification enhances efficiency and specificity of gene overexpression by preventing Prkra-mediated global translation repression |
| 最近邻树算法与哈达玛变换在系统发育推断中的进展与应用 |
Alvarez Gonzalez, E. |
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N/A |
Advances and applications of the closest-tree algorithm and Hadamard conjugation in phylogenetic inference |
| EXTRA-seq：一种基因组整合的扩展型大规模并行报告基因分析方法，用于量化增强子-启动子通信 |
Kribelbauer-Swietek, J. F. |
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N/A |
EXTRA-seq: a genome-integrated extended massively parallel reporter assay to quantify enhancer-promoter communication |
| 生成式人工智能辅助的虚拟筛选流程，用于通用且高效的药物再利用 |
Pham, P. |
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N/A |
Generative AI-assisted Virtual Screening Pipeline for Generalizable and Efficient Drug Repurposing |
| 信标重建攻击：利用汇总统计数据在基因组数据共享信标中重建基因组 |
Saleem, K. |
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N/A |
Beacon Reconstruction Attack: Reconstruction of genomes in genomic data-sharing beacons using summary statistics |
| 将自然语言处理与基因组分析相结合，能够实现对细菌表型的精确预测。 |
Gomez-Perez, D. |
PDF |
N/A |
Integrating natural language processing and genome analysis enables accurate bacterial phenotype prediction |
| L2G：将语言模型重新用于基因组学任务 |
Cheng, W. |
PDF |
N/A |
L2G: Repurposing Language Models for Genomics Tasks |
| Kolmogorov-Arnold网络用于基因组任务 |
Cherednichenko, O. |
PDF |
N/A |
Kolmogorov-Arnold Networks for Genomic Tasks |
| 成对图编辑距离表征了构建方法对泛基因组图的影响 |
Dubois, S. |
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N/A |
Pairwise graph edit distance characterizes the impact of the construction method on pangenome graphs |
| 整合单细胞RNA测序和空间转录组学揭示了在股骨髋臼撞击症和骨关节炎患者的人类髋关节滑膜中，巨噬细胞与成纤维细胞之间的不同相互作用。 |
Kulzhanova, G. |
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N/A |
Integrative scRNA-seq and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis |
| 塞米利琴 - 一种被不公正忽视的绿色生物膜与真菌地衣之间的共生系统 |
Vondrak, J. |
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N/A |
Semilichen - an unjustly neglected symbiotic system between green biofilms and true lichens |
| 肌肉长度根据收缩类型的不同，对复发性抑制和激活后抑制的调节作用也有所不同。 |
Colard, J. |
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N/A |
Muscle length modulates recurrent inhibition and post-activation depression differently according to contraction type |
| 言语掩蔽对人类对连续言语的皮层下反应的影响 |
Polonenko, M. J. |
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N/A |
The effect of speech masking on the human subcortical response to continuous speech |
| 比较糖皮质激素对人MR（Ile-180）和人MR单倍型（Ile180Val）的转录激活作用 |
Katsu, Y. |
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N/A |
Comparison of Transcriptional Activation by Corticosteroids of Human MR (Ile-180) and Human MR Haplotype (Ile180Val) |
| 深度预测编码网络部分捕捉到了人类视觉皮层中短期时间适应的神经特征。 |
Brands, A. M. |
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N/A |
Deep predictive coding networks partly capture neural signatures of short-term temporal adaptation in human visual cortex |
| 海马神经元的轴突和树突中，不稳定铁的储存和运输是由溶酶体介导的。 |
Kittilukkana, A. |
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N/A |
Storage and transport of labile iron is mediated by lysosomes in axons and dendrites of hippocampal neurons |
| LC3相关胞吞作用促进小胶质细胞对外源Tau聚集体的内化和降解 |
CHIDAMBARAM, H. |
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N/A |
LC3-associated endocytosis facilitates extracellular Tau aggregate internalization and degradation in microglia |
| 介导视交叉上核昼夜节律同步的功能性连接组 |
Nikhil, K. L. |
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N/A |
The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus |
| 血管性痴呆患者脑室周围白质单核RNA测序 |
Diaz-Perez, S. |
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N/A |
Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia |
| FAM53C/DYRK1A轴调控细胞周期G1/S期的转换 |
Hammond, T. |
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N/A |
THE FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle |
| Tet2和Tet3在视网膜发育过程中调控细胞命运的确定和分化事件。 |
Heilman, S. |
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N/A |
tet2 and tet3 regulate cell fate specification and differentiation events during retinal development |
| 在发育和进化的时间尺度上基因共表达的灵活性 |
Fischer, E. K. |
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N/A |
Flexibility in Gene Coexpression at Developmental and Evolutionary Timescales |
| 在马拉维湖慈鲷中，与营养级相关的肠道长度分化是在性冲突下演化而来的。 |
Carmona Baez, A. |
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N/A |
Trophic level associated gut length divergence evolved under sexual conflict in Lake Malawi cichlids |
| 识别群体采样的亲代-子代三联体中的因果基因型-表型关系 |
Tang, Y. |
PDF |
N/A |
Identifying causal genotype-phenotype relationships for population-sampled parent-child trios |
| 追踪植物卤化酶的逐步达尔文进化过程 |
Kim, C. Y. |
PDF |
N/A |
Tracing the stepwise Darwinian evolution of a plant halogenase |
| 星相位：全面相位感知药物基因组学双倍体型分析工具，适用于长读长测序数据 |
Holt, J. M. |
PDF |
N/A |
StarPhase: Comprehensive Phase-Aware Pharmacogenomic Diplotyper for Long-Read Sequencing Data |
| GEMS：一种通过稳健数据过滤和语言模型整合进行蛋白质-配体结合亲和力预测的通用图神经网络框架 |
Graber, D. |
PDF |
N/A |
GEMS: A Generalizable GNN Framework For Protein-Ligand Binding Affinity Prediction Through Robust Data Filtering and Language Model Integration |
| LSD1去甲基化酶抑制可预防小鼠和猪模型中心肌纤维化，无论是缺血性还是先天性疾病。 |
ARNAUD, D. |
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N/A |
LSD1 demethylase inhibition prevents cardiac fibrosis in both ischemic and congenital diseases in mice and pig models |
| 在连续耕作下的作物比在间歇耕作下的作物表现出较少的可塑性。 |
Alagarasan, G. |
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N/A |
Crops under continuous cultivation exhibit less plasticity than those under interrupted cultivation |
| 复杂阿片类药物对与情绪、奖赏和成瘾相关的GABA能脑核中谷氨酸能和胆碱能神经传递的调节作用。 |
Chittajallu, R. |
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N/A |
Complex opioid driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward and addiction. |
| 认知疲劳对基于体力努力的决策影响的神经机制 |
Dryzer, M. |
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N/A |
Neural mechanisms underlying the effects of cognitive fatigue on physical effort-based decision-making |
| 默认模式和运动网络促进隐性运动序列的早期学习：一项多模态磁共振波谱和功能磁共振成像研究 |
Hendrikse, J. J. |
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N/A |
Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study |
| 表观遗传因子KDM6A的去调控在白色念珠菌介导的伤口愈合延迟过程中起作用。 |
Ghoshal, A. |
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N/A |
Deregulation of epigenetic factor, KDM6A, is involved during Candida albicans mediated delayed wound healing |
| BAZ2依赖的染色质重塑在抑制G4 DNA结构及其相关基因组不稳定性中的作用 |
Vandeuren, A. L. |
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N/A |
The Role of BAZ2-dependent Chromatin Remodeling in Suppressing G4 DNA Structures and Associated Genomic Instability |
| HP1结合在局部形成了一个对抗转录激活的屏障，并且在染色质解凝过程中持续存在。 |
Weinmann, R. |
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N/A |
HP1 binding creates a local barrier against transcription activation and persists during chromatin decondensation |
| 解决控制出生后血管生长和比例的设计原则 |
Pichardo, D. |
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N/A |
Resolving the design principles that control postnatal vascular growth and scaling |
| H3.1K27M诱导的TSK/TONSL-H3.1通路失调导致基因组不稳定性 |
Yuan, W. |
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N/A |
H3.1K27M-induced misregulation of the TSK/TONSL-H3.1 pathway causes genomic instability |
| 酵母（Saccharomyces cerevisiae）减数分裂所需的组蛋白H3尾部修饰 |
Prichard, A. |
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N/A |
Histone H3 tail modifications required for meiosis in Saccharomyces cerevisiae |
| 在鹅膏菌（Podospora anserina）中，性繁殖受到连续的转录组波动的调控。 |
Bidard, F. |
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N/A |
Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina |
| Inkube：一种集神经元培养、电生理学和流体交换于一体的综合解决方案 |
Maurer, B. |
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N/A |
Inkube: An all-in-one solution for neuron culturing, electrophysiology, and fluidic exchange |
| 蛋白质语言模型的伪似然性捕捉了体内B细胞选择和进化的特征 |
van Ginneken, D. |
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N/A |
Protein language model pseudolikelihoods capture features of in vivo B cell selection and evolution |
| 可解释图学习在多模态单细胞数据整合中的应用 |
Koca, M. B. |
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N/A |
Explainable Graph Learning for Multimodal Single-Cell Data Integration |
| PathOmCLIP：通过局部增强的病理学和单细胞基础模型的对比学习，将肿瘤组织学与空间基因表达相连接 |
Lee, Y. |
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N/A |
PathOmCLIP: Connecting tumor histology with spatial gene expression via locally enhanced contrastive learning of Pathology and Single-cell foundation model |
| 单细胞质谱分析揭示了苹果愈伤组织衍生细胞中三萜酸积累的异质性。 |
Laezza, C. |
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N/A |
Single-cell mass spectrometry reveals heterogeneous triterpenic acid accumulation in apple callus-derived cells |
| 光合作用和遗传适应性支撑着Cistanthe longiscapa在阿塔卡马沙漠中的韧性 |
Sandoval-Ibanez, O. |
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N/A |
Photosynthetic and Genetic Adaptations Underpinning the Resilience of Cistanthe longiscapa in the Atacama Desert |
| 染色体工程揭示了染色体臂特异性端粒长度设定的顺式作用机制，以及植物表型、染色质结构和基因表达的稳健性。 |
Helia, O. |
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N/A |
Chromosome engineering points to the cis-acting mechanism of chromosome arm-specific telomere length setting and robustness of plant phenotype, chromatin structure and gene expression |
| 减少与冗余：睡眠期间预测误差的信息处理 |
Blume, C. |
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N/A |
Reduced and Redundant: Information Processing of Prediction Errors during Sleep |
| 克隆扩增的IgG抗体分泌细胞在同源和异源感染后优先靶向流感核蛋白。 |
Agrafiotis, A. |
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N/A |
Clonally expanded IgG antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections |
| 超多样性、生物活性以及相互作用特异性的代谢产物仅在共培养中产生，这表明多样化的竞争者可能促进了木霉菌类真菌的次级代谢。 |
Franco, M. E. E. |
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N/A |
Hyperdiverse, bioactive, and interaction-specific metabolites produced only in co-culture suggest diverse competitors may fuel secondary metabolism of xylarialean fungi |
| 受体酪氨酸激酶信号通路的下游分支相互依赖，共同塑造了面部的形态。 |
Hanne, N. |
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N/A |
Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face |
| 植物中异形性染色体的演化 |
Carey, S. B. |
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N/A |
The evolution of heteromorphic sex chromosomes in plants |
| 蛋白质热稳定性的广泛差异是由结构变化和细胞环境共同介导的。 |
Walunjkar, N. |
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N/A |
Pervasive divergence in protein thermostability is mediated by both structural changes and cellular environments |
| 栉水母和副盒形动物分别独立演化出了复杂且功能多样的电压门控K+通道集合。 |
Simonson, B. T. |
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N/A |
Ctenophores and parahoxozoans independently evolved complex and functionally diverse sets of voltage-gated K+ channels |
| 两种不同热液液化工艺废水的毒性和生物降解性对厌氧消化的影响及微氧化的效果 |
Zhou, M. |
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N/A |
Toxicity and Biodegradation of Two Different Hydrothermal Liquefaction Process Waters to Anaerobic Digestion and the Effect of Microaeration |
| 利用生成式人工智能学习并改进蛋白质适应性高通量筛选——应用于血脑屏障穿透AAV设计 |
Soniya, K. |
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N/A |
Learning from and improving upon high-throughputscreens for protein fitness with Generative AI - Application to BBB-crossing AAV design |
| PathoFact 2.0：一种综合性的管道，用于在宏基因组中预测抗菌药物抗性基因、毒力因子、毒素和生物合成基因簇。 |
Sunyer, J. O. |
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N/A |
PathoFact 2.0: An Integrative Pipeline for Predicting Antimicrobial Resistance Genes, Virulence Factors, Toxins and Biosynthetic Gene Clusters in Metagenomes |
| 通过WAY262611抑制DKK-1可抑制骨肉瘤的转移。 |
Tal, A. |
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N/A |
Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis |
| Wnt靶标IQGAP3通过破坏Axin1-CK1α相互作用促进Wnt信号传导。 |
Rahmat, M. B. |
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N/A |
Wnt target IQGAP3 promotes Wnt signaling via disrupting Axin1-CK1α interaction. |
| 在鹰嘴豆中，性状均值和可塑性具有不同的遗传结构 |
Alagarasan, G. |
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N/A |
Distinct genetic architecture for trait mean and plasticity in chickpea |
| STING激动剂通过驱动单核细胞谱系细胞中的招募和内在I型干扰素反应，以实现最佳的抗肿瘤免疫。 |
Girard, M. |
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N/A |
STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity |
| 装载真核翻译起始因子的细胞外囊泡促进卵巢癌中的巨噬细胞胆固醇代谢 |
Mittal, S. |
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N/A |
Eukaryotic Translation Initiation Factor Loaded Extracellular Vesicles Promotes Macrophage Cholesterol Metabolism in ovarian cancer |
| 与人类大脑功能连接组相关的细胞类型及其在精神疾病中的意义 |
Nie, P. |
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N/A |
Cell types associated with human brain functional connectomes and their implications in psychiatric diseases |
| 炎症与DNA损伤的交叉作为自闭症谱系障碍发病机制中的一个新轴 |
lizarraga, s. B. |
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N/A |
The intersection of inflammation and DNA damage as a novel axis underlying the pathogenesis of autism spectrum disorders |
| 炎症与DNA损伤的交叉作为自闭症谱系障碍发病机制中的一个新轴 |
Jhanji, M. |
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N/A |
The intersection of inflammation and DNA damage as a novel axis underlying the pathogenesis of autism spectrum disorders |
| 在不同实验室间协调巨细胞病毒载量定量方面，仍存在哪些挑战？ |
Boutolleau, D. |
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N/A |
What challenges remain in harmonizing cytomegalovirus viral load quantification across laboratories? |
| 开发富含侵袭素的外膜囊泡（OMVs）作为疫苗以控制肠出血性大肠杆菌的肠道携带 |
Garling, A. |
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N/A |
Development of intimin-enriched outer membrane vesicles (OMVs) as a vaccine to control intestinal carriage of Enterohemorrhagic Escherichia coli |
| 行走的能量消耗是否限制了更大人类产道的发展？ |
Stansfield, E. |
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N/A |
Did Energy Costs of Walking Limit the Evolution of a Larger Human Birth Canal? |
| 鉴定与舞毒蛾滞育相关的差异表达基因和蛋白质：通过转录组和蛋白质组分析揭示滞育机制的见解 |
Xie, Q. |
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N/A |
Identification of Differentially Expressed Genes and Proteins Related to Diapause in Lymantria Dispar: Insights for the Mechanism of Diapause from Transcriptome and Proteome Analyses |
| 冬眠测量与解释工具（TOHMIN）用于从冬眠期间的体温波动中量化各种数值。 |
Otsuka, R. |
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N/A |
Tools of Hibernation Measurement and Interpretation (TOHMIN) for quantifying various values from body temperature fluctuation during hibernation |
| 类胡萝卜素衍生物信号调控了拟南芥中分生组织的活性，并塑造了茎和根的侧生器官的形成。 |
Sierra, J. |
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N/A |
Apocarotenoid signaling regulates meristem activity and shapes shoot and root lateral organ formation in Arabidopsis |
| 多发性硬化症患者的少突胶质细胞表现出一种细胞自主性的免疫激活状态。 |
Hyvarinen, T. |
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N/A |
Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state |
| ATF5依赖的GDF15表达介导麻醉诱导的抗中风神经保护作用 |
Ju, X. |
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N/A |
ATF5-Dependent GDF15 Expression Mediates Anesthesia-Induced Neuroprotection Against Stroke |
| 大型MAF转录因子在人类骨骼肌中重新激活进化上休眠的快速糖酵解型IIb肌纤维 |
Sadaki, S. |
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N/A |
Large MAF Transcription Factors Reawaken Evolutionarily Dormant Fast-Glycolytic Type IIb Myofibers in Human Skeletal Muscle |
| 一种扩散的、多组织伤口信号启动了全身再生 |
Breen, C. |
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N/A |
A spreading, multi-tissue wound signal initiates whole-body regeneration |
| 一个转录因子触发开关决定了水螅表皮细胞的分化身份。 |
Ferenc, J. |
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N/A |
A transcription factor toggle switch determines differentiated epidermal cell identities in Hydra |
| 相邻细胞间的直接细胞内囊泡交换 |
Minakawa, T. |
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N/A |
Direct Intercellular Vesicle Exchange between Adjacent Cells |
| 将生态位从个体扩展到种群及更广泛的范围 |
Lu, M. |
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N/A |
Scaling ecological niches from individuals to populations and beyond |
| 无对齐病毒序列分类 |
van Zyl, D. J. |
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N/A |
Alignment Free Viral Sequence Classification |
| 使用200 kV电子冷冻显微镜对哺乳动物细胞进行原位结构分析：对研究基础设施的意义。 |
Szwedziak, P. |
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N/A |
In situ structural analysis of mammalian cells using a 200 kV electron cryomicroscope: implications for research infrastructure. |
| SARS-CoV-2融合肽片段对模型膜作用的脂质特异性 |
Shekunov, E. V. |
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N/A |
Lipid specificity of action of SARS-CoV-2 fusion peptide fragments on model membranes |
| 肾动脉功能障碍、压力性利尿受损及盐敏感性增加——库欣综合征小鼠模型中的表现 |
Costello, H. M. |
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N/A |
Renal arterial dysfunction, impaired pressure natriuresis and salt-sensitivity in a mouse model of Cushing syndrome |
| 刺激重复对猕猴V1和V4微电路的影响解释了伽马同步增加的现象。 |
Katsanevaki, C. |
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N/A |
Stimulus-repetition effects on macaque V1 and V4 microcircuits explain gamma-synchronization increase |
| 活减毒疫苗与腺病毒载体疫苗联合使用可完全保护干扰素γ（IFNγ）敲除小鼠免受肺鼠疫的侵害。 |
Hendrix, E. K. |
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N/A |
Combination of live attenuated and adenovirus-based vaccines completely protects interferon gamma (IFNγ) knockout mice against pneumonic plague |
| 从摄入到消化，人类母乳微生物群可培养性新见解及其对免疫调节特性的启示 |
Le Bras, C. |
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N/A |
New insights into the cultivability of human milk microbiota from ingestion to digestion and implications for its immunomodulatory properties |
| 触发诱惑：一种比较大鼠由辨别性和条件性刺激引发的趋奖行为的新方法 |
LeCocq, M. R. |
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N/A |
Triggered Temptations: A New Procedure to Compare Reward-Seeking Behaviour Induced by Discriminative and Conditioned Stimuli in Rats |
| 植物相关细菌中的化学受体家族优先响应植物信号分子甘油-3-磷酸 |
Velando, F. |
PDF |
N/A |
Chemoreceptor family in plant-associated bacteria responds preferentially to the plant signal molecule glycerol 3-phosphate |
| 对近乎完整的基因组进行独家编目揭示了人类肠道微生物群的新功能见解 |
Ma, J. |
PDF |
N/A |
Exclusive cataloging of near-complete genomes unveils novel functional insights into the human gut microbiome |
| 包含克拉霉素、氯法齐明和贝达喹啉的治疗方案在慢性鸟分枝杆菌肺部感染的小鼠模型中比单一疗法更有效。 |
Rimal, B. |
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N/A |
Regimen comprising clarithromycin, clofazimine and bedaquiline is more efficacious than monotherapy in a mouse model of chronic Mycobacterium avium lung infection |
| 细菌裂解多糖单加氧酶对昆虫幼虫生长有负面影响。 |
Baranek, J. |
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N/A |
Bacterial Lytic Polysaccharide Monooxygenases negatively affect insect larvae growth |
| 两种托斯卡纳病毒在小鼠和细胞培养模型中表现出不同的毒力和复制能力。 |
Roy, M. |
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N/A |
Two strains of Toscana virus show different virulence and replication capacity in mice and cell culture models |
| 通过动物肠道内容物的宏转录组测序检测外来生物安全威胁的雀麦花叶病毒及新型烟草花叶病毒 |
Mahar, J. |
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N/A |
Detection of exotic biosecurity threat ribgrass mosaic virus and novel tobamoviruses through metatranscriptomic sequencing of animal gut content |
| 使用数字滴定PCR技术计数稀有的沃尔巴克氏体共生体 |
Njogu, A. K. |
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N/A |
Counting rare Wolbachia endosymbionts using digital droplet PCR |
| 针对FimH粘附素单克隆抗体可预防尿路致病性大肠杆菌引起的尿路感染。 |
Lopatto, E. D. B. |
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N/A |
Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI |
| 金黄色葡萄球菌噬菌体80a颈部结构的分析揭示了DNA、尾部完成蛋白和卷尺蛋白之间的相互作用。 |
Kizziah, J. L. |
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N/A |
Structure of the Staphylococcus aureus bacteriophage 80a neck shows the interactions between DNA, tail completion protein and tape measure protein |
| 霍乱弧菌O1 El Tor A1552菌株编码两种功能性的鸟氨酸脂合成酶，并在低磷酸盐和低盐度生长条件下诱导鸟氨酸脂的形成。 |
Vences-Guzman, M. A. |
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N/A |
Vibrio cholerae O1 El Tor A1552 encodes two functional ornithine lipid synthases and induces ornithine lipid formation under low phosphate and under low salinity growth conditions. |
| 稳定同位素指纹技术可以直接将肠道微生物与其碳源联系起来，并捕捉到体内由饮食引起的底物转换。 |
Mordant, A. |
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N/A |
Stable isotope fingerprinting can directly link intestinal microorganisms with their carbon source and captures diet-induced substrate switching in vivo |
| 铜绿假单胞菌的PrrF sRNAs在体温条件下促进生物膜的形成。 |
Chourashi, R. |
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N/A |
The Pseudomonas aeruginosa PrrF sRNAs promote biofilm formation at body temperature |
| 基于CRISPR的人工智能辅助环境生物监测，通过人工智能设计引导RNA |
Duran-Vinet, B. |
PDF |
N/A |
CRISPR-based environmental biosurveillance assisted via artificial intelligence design of guide-RNAs |
| 急性感染期间肠道微生物组特征可预测长期新冠 |
Comba, I. Y. |
PDF |
N/A |
Gut Microbiome Signatures During Acute Infection Predict Long COVID |
| 蛋白质和DNA构象变化有助于Cre重组酶的特异性 |
Montgomery, J. S. |
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N/A |
Protein and DNA Conformational Changes Contribute to Specificity of Cre Recombinase |
| 海藻酸盐操控的多功能工具——一种具有多种催化活性的肠道细菌海藻酸盐裂解酶 |
Tandrup, T. |
PDF |
N/A |
The Swiss Army Knife of Alginate Manipulation - A Gut Bacterium Alginate Lyase with Diverse Catalytic Activities |
| 新型及多样亨尼帕病毒糖蛋白的结构与抗原特性研究 |
May, A. J. |
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N/A |
Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins |
| 开发一种新型蛋白质结合剂，抑制α激酶eEF2K |
Klupt, K. A. |
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N/A |
Development of a De Novo Protein Binder that Inhibits the Alpha Kinase eEF2K |
| 通过DNA语言模型解读宏基因组读取中的酶学潜力 |
R, P. |
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Deciphering enzymatic potential in metagenomic reads through DNA language model |
| 在埃希氏大肠杆菌中设计合成生物路线以生产(+)-短杆菌肽A和B |
Sandoval Hurtado, C. P. |
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Engineering a Biosynthetic Pathway for the Production of (+)-Brevianamides A and B in Escherichia coli |
| 使用合成基因电路编程哺乳动物细胞聚集体的延伸 |
Courte, J. |
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Programming the elongation of mammalian cell aggregates with synthetic gene circuits |
| 无需校准的场依赖像差估计方法，用于大视场范围内的单分子定位显微镜 |
Rieger, B. |
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Calibration-free estimation of field dependent aberrations for single molecule localization microscopy across large fields of view |
| 人类血浆代谢环境有利于HIV在原代CD4 T淋巴细胞中的复制。 |
Chauveau, L. |
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Human plasma metabolic environment favours HIV replication in primary CD4 T lymphocytes |
| 鉴定并确定了大肠杆菌噬菌体YDC107尾部在细菌污染缓冲液中的冷冻电镜结构 |
Kopylov, M. |
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Identification and cryoEM structure determination of Escherichia phage YDC107 tail found in a bacteria-contaminated buffer |
| 沙门氏菌染色体的演变及其对基因表达和染色体构象的影响 |
Hu, Y. |
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Evolution of Salmonella Chromosomes and Its Influence on Gene Expression and Chromosomal Conformation |
| HDAC6介导的FoxO1乙酰化和磷酸化调控牙周炎症反应 |
Lohner, H. |
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HDAC6-Mediated FoxO1 Acetylation And Phosphorylation Control Periodontal Inflammatory Responses |
| 精确的计算机模拟预测修饰RNA与典型RNA结合蛋白的相互作用，采用{lambda}-动力学方法 |
Angelo, M. |
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Accurate in silico predictions of modified RNA interactions to a prototypical RNA-binding protein with {lambda}-dynamics |
| 跨膜苯丙氨酸残基对γ-分泌酶介导的Notch-1蛋白水解的影响 |
Malvankar, S. |
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Effects of transmembrane phenylalanine residues on γ-secretase-mediated Notch-1 proteolysis |
| PRMT1调控的RNA结合蛋白级联反应的寡聚化促进胰腺导管腺癌的发展 |
Ru, Y. |
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Oligomerization of PRMT1 Regulated RNA-Binding Protein Cascade Promotes Pancreatic Ductal Adenocarcinoma |
| 通过单分子荧光揭示RNA聚合酶II转录激活中的协同介质招募机制 |
Zhou, D. H. |
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Mechanisms of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence |
| 鉴定来自马来西亚芙蓉市的伊丽莎白金菌临床分离株中的新型前噬菌体和整合接合元件的变体 |
Zajmi, A. |
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Identification of novel prophages and variants of Integrative and Conjugative Elements in Elizabethkingia anophelis clinical isolates from Seremban, Malaysia |
| 在根癌农杆菌中，ChvG-ChvI通路的激活促进了细胞壁应激下的多种生存策略。 |
Bouchier, J. M. |
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Activation of the ChvG-ChvI pathway promotes multiple survival strategies during cell wall stress in Agrobacterium tumefaciens |
| 基因流动可以揭示幽灵谱系。 |
Tricou, T. |
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Gene flow can reveal ghost lineages |
| 碱性磷酸酶家族中的祖先芳基硫酸酯酶相较于现存变体，能够实现更高的催化效率提升。 |
Eenink, B. |
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Ancestral aryl sulfatases in the alkaline phosphatase family allow for greater increases in catalytic efficiency than extant variants |
| 在斑胸草雀的X区通过慢病毒敲低STEP后，改进了等时脉冲 |
Norton, P. |
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An improved isochronous pulse after lentiviral knock-down of STEP in Area X of juvenile zebra finches |
| 具有自体和发育相关心脏神经嵴衍生组织的人类心脏自组装体 |
Kostina, A. |
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Self-organizing human heart assembloids with autologous and developmentally relevant cardiac neural crest-derived tissues |
| 血清素系统的发展和成年期的功能受到GDNF的调控。 |
Garton, D. R. |
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Serotonin system development and adult function are regulated by GDNF |
| 单次延长应激对行为反应的性别特异性调控：PACAP的作用 |
Smail, M. A. |
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Sex-Specific Regulation of Behavioral Responses to Single Prolonged Stress: Role of PACAP |
| 绘制人类大脑中的神经肽信号传导图 |
Ceballos, E. G. |
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Mapping neuropeptide sigaling in the human brain |
| RegVelo：单细胞基因调控动力学 |
Wang, W. |
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RegVelo: gene-regulatory-informed dynamics of single cells |
| 适应状态决定了突变对进化种群的影响。 |
Weh, M. T. |
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The adaptive state determines the impact of mutations on evolving populations |
| 海马体中特定频率的θ状态会根据行为背景调节群体活动。 |
Masaracchia, L. |
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Frequency-specific theta states in the hippocampus modulate population activity with respect to behavioural context |