| 感觉体验通过涉及degenerins的不同途径控制树突结构和行为。 |
Inberg, S. |
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N/A |
Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins |
| 在概率性奖励学习过程中通过小鼠内侧前额叶皮层进行的变化点估计 |
Murphy, C. E. |
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N/A |
Change point estimation by the mouse medial frontal cortex during probabilistic reward learning |
| 去泛素化抑制剂与SARS-CoV-2木瓜样蛋白酶结合的活性分析及其在鼠感染模型中的抗病毒效果 |
Choudhary, S. |
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N/A |
Activity profiling of deubiquitinating inhibitors-bound to SARS-CoV-2 papain like protease with antiviral efficacy in murine infection model |
| 已撤回：Progranulin通过抑制磷脂酶sPLA2-IIA来控制神经炎症 |
Du, H. |
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N/A |
WITHDRAWN: Progranulin inhibits phospholipase sPLA2-IIA to control neuroinflammation |
| 新皮层微电路和中间电路的建模与仿真。第二部分：生理学与实验 |
Isbister, J. B. |
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N/A |
Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation |
| 人工语言和自然语言是由相同的大脑机制处理的。 |
Malik-Moraleda, S. |
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N/A |
Constructed languages are processed by the same brain mechanisms as natural languages |
| 城市边缘地区的池塘水质是否会影响大型无脊椎动物的丰度和群落结构？ |
Hulot, F. D. |
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N/A |
Do macroinvertebrate abundance and community structure depend on the quality of ponds located in peri-urban areas? |
| 二元判别器助力基于GPT的蛋白质设计 |
Zeng, Z. |
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N/A |
Binary Discriminator Facilitates GPT-based Protein Design |
| 在实验范式中比较随机交配和定时交配的小鼠 |
Khurshid, M. |
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N/A |
Comparing random and timed mating of mice in the experimental paradigm |
| 2-氧戊二酸触发活性十二聚体甲烷八叠球菌谷氨酰胺合成酶的组装。 |
Herdering, E. |
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N/A |
2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase |
| 变异效应预测器与功能测定之间的相关性反映了其在临床分类中的表现。 |
Livesey, B. J. |
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N/A |
Variant effect predictor correlation with functional assays is reflective of clinical classification performance |
| CRASH2p：自由活动动物中的闭环双光子成像 |
McNulty, P. |
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N/A |
CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal |
| SaprotHub：让蛋白质建模变得触手可及，惠及所有生物学家 |
Su, J. |
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N/A |
SaprotHub: Making Protein Modeling Accessible to All Biologists |
| 通过PHORCE揭示了噬菌体扩增速率的极端多样性以及噬菌体与抗生素相互作用的复杂性。 |
Mulla, Y. |
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N/A |
Extreme diversity of phage amplification rates and phage-antibiotic interactions revealed by PHORCE |
| 视觉运动延迟变化感知中的基线依赖性差异 |
Vigh, G. |
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N/A |
Baseline dependent differences in the perception of changes in visuomotor delay |
| 决定成败的细菌基因组编辑之关键——碱基编辑技术 |
Rengifo-Gonzalez, M. |
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N/A |
Make-or-break prime editing for bacterial genome engineering |
| 对称性促进了脊椎动物血红蛋白中特异性和高阶化学计量的进化。 |
Cortez-Romero, C. R. |
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N/A |
Symmetry facilitated the evolution of specificity and high-order stoichiometry in vertebrate hemoglobin |
| 酵母类溶酶体液泡上的V-ATP酶解体是复制性衰老中溶酶体功能障碍的表型驱动因素 |
Hashmi, F. |
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N/A |
V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is aPhenotypic Driver of Lysosome Dysfunction in Replicative Aging |
| 使用sciRED进行可解释的单细胞因子分解 |
Pouyabahar, D. |
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N/A |
Interpretable single-cell factor decomposition using sciRED |
| 与造血障碍相关的DNA-GATA1结合改变的定量分析 |
Zambo, B. |
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N/A |
Quantitative analysis of DNA-GATA1 binding alterations linked to hematopoietic disorders |
| 乌库尼埃米病毒感染会导致蜱细胞培养中RNA结合蛋白组的广泛重塑。 |
Wilson, A. |
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N/A |
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cell cultures |
| 量化生物物理因素对通过残余功能网络塑造大脑交流的影响 |
Nakuci, J. |
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N/A |
Quantifying the influence of biophysical factors in shaping brain communication through remnant functional networks |
| 阿塔卡马沙漠土壤生物多样性的层次模式：跨越生物尺度的洞察 |
Villegas, L. |
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N/A |
Hierarchical Patterns of Soil Biodiversity in the Atacama Desert: Insights Across Biological Scales |
| O-特异性抗原的丧失塑造了铜绿假单胞菌在小鼠临床前肺部感染模型中的微生物地理分布。 |
Fraser, H. |
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N/A |
Loss of O-specific antigen shapes Pseudomonas aeruginosa microbiogeography in murine preclinical pulmonary infection model |
| R-Loop的调控及线粒体基因组的稳定性需要5'-3'外切酶/切口内切酶OEX1的参与。 |
Schatz-Daas, D. |
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N/A |
R-Loop control and mitochondria genome stability requires the 5'-3' exonuclease/flap-endonuclease OEX1 |
| 个体间基因表达的变异性意味着大脑偏好基因在各器官中的稳定调控。 |
Bucao, C. F. |
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N/A |
Inter-individual gene expression variability implies stable regulation of brain-biased genes across organs |
| 脂肪源性间充质干细胞与视网膜色素上皮细胞在应激环境中的相互作用通过纳米管隧道进行 |
Gozel, M. |
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N/A |
Adipose-derived Mesenchymal Stem Cells and Retinal Pigment Epithelial Cells Interactions in Stress Environment via Tunneling Nanotubes |
| 阅读习得促使语言跨模态整合在左腹侧枕颞皮层中发生 |
Debska, A. |
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N/A |
Reading Acquisition Drives Linguistic Cross-Modal Convergence in The Left Ventral Occipitotemporal Cortex |
| 环境DNA与社区科学：城市蜻蜓调查的优势与局限 |
Uche-Dike, R. |
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N/A |
Environmental DNA vs. Community Science: Strengths and Limitations for Urban Odonata Surveys |
| Brisk：精确的资源高效型k-mers字典 |
Smith, C. |
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N/A |
Brisk: Exact resource-efficient dictionary for k-mers |
| OMAnnotator：一种构建注释共识基因组序列的新方法 |
Bates, S. |
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N/A |
OMAnnotator: a novel approach to building an annotated consensus genome sequence |
| 大效应生活史基因组区域与大西洋鲑的功能形态特征相关 |
Aykanat, T. |
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N/A |
Large effect life-history genomic regions are associated with functional morphological traits in Atlantic salmon |
| 欧洲河七鳃鳗（Lampetra fluviatilis）和溪七鳃鳗（Lampetra planeri）全基因组组装的比较 |
Torresen, O. K. |
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N/A |
Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri) |
| 利用合成血清标志物进行体内转录监测 |
Watanabe, S. |
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N/A |
Monitoring in vivo transcription with synthetic serum markers |
| 基准测试人体步态模拟的预测能力。 |
Afschrift, M. |
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N/A |
Benchmarking the predictive capability of human gait simulations. |
| 丘脑网状核亚群的生物物理建模及其对网络动力学的不同贡献 |
Litvak, P. |
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N/A |
Biophysical modeling of thalamic reticular nucleus subpopulations and their differential contribution to network dynamics |
| 在一年生植物的有性生殖分配实验进化过程中，处理效应的重复性以及群体间的差异 |
Villamil, N. |
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N/A |
Replication of treatment effects and differences among populations during experimental evolution of sex allocation in an annual plant |
| 基于蛋白质冠的纳米组学对细菌病原体感染后植物应激生物标志物的深度分析 |
Coreas, R. |
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N/A |
Deep profiling of plant stress biomarkers following bacterial pathogen infection with protein corona based nano-omics |
| 与NGAL基因的多效性作用相关的发展性重连NGAL/CUC/KLU网络 |
Nicolas, A. |
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N/A |
Developmental rewiring of the NGAL/CUC/KLU network associated with pleiotropic roles of NGAL genes |
| 一种基于针状的双功能VOC传感平台，用于快速蔬菜质量检测 |
Hossain, O. |
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N/A |
A Dual-Functional Needle-Based VOC Sensing Platform for Rapid Vegetable Quality Examination |
| 植物-病原体相互作用的代谢建模量化了导致细菌性枯萎病的代谢瓶颈。 |
Gerlin, L. |
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N/A |
Metabolic modeling of a plant-pathogen interaction quantifies the metabolic bottlenecks underlying bacterial wilt |
| 整合组学揭示了小麦水分利用效率和抗旱性的遗传基础及TaMYB7-A1的功能 |
Xiao, J. |
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N/A |
Integrative Omics reveals genetic basis and TaMYB7-A1's function in wheat WUE and drought resilience |
| 决定温带适应型高粱开花时间变异的基因和通路 |
Mangal, H. |
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N/A |
Genes and pathways determining flowering time variation in temperate adapted sorghum |
| 使用大规模RNA-seq数据集预测植物性状 |
Hadish, J. A. A. |
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N/A |
Predicting plant traits using large conglomerate RNA-seq datasets |
| 使用物种分布模型将潜在的太平洋植物入侵者列入黑名单时存在不确定性 |
Holle, V. |
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N/A |
Uncertainty in blacklisting potential Pacific plant invaders using species distribution models |
| 在中部蒙特沙漠中，食虫鸟类对植物选择中猎物丰富度和叶结构的影响 |
Guerra-Navarro, C. |
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N/A |
Effects of prey abundance and foliage structure in plant selection by insectivorous birds in the central Monte desert |
| 年龄和性别影响狮尾猕猴（Macaca silenus）对本地和非本地植物种子的传播。 |
K, B. |
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N/A |
Age and sex influence seed dispersal of native and non-native plants by Lion-tailed Macaques Macaca silenus |
| 无需参考的辅助染色体鉴定与泛基因组分析在主要植物病原真菌中的应用 |
van Westerhoven, A. |
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N/A |
Reference-free identification and pangenome analysis of accessory chromosomes in a major fungal plant pathogen |
| 短尾调控语法和脊索起源的深层同源性 |
Fan, T.-P. |
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N/A |
Deep homology of a brachyury regulatory syntax and origin of the notochord |
| 基准测试用于生物学上保守的单细胞整合的深度学习方法 |
Yi, C. |
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N/A |
Benchmarking deep learning methods for biologically conserved single-cell integration |
| 卷曲螺旋结构域对生物分子凝聚物相行为的影响 |
He, Z. |
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N/A |
The Impact of Coiled-Coil Domains on the Phase Behavior of Biomolecular Condensates |
| 基于个性化多尺度模拟的股骨生长预测：力学生物学模型的验证与敏感性分析 |
Koller, W. |
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N/A |
Femoral bone growth predictions based on personalized multi-scale simulations: Validation and sensitivity analysis of a mechanobiological model |
| 鉴定和药理学表征游离脂肪酸1受体上的多个变构结合位点 |
Venka, K. |
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N/A |
Identification and Pharmacological Characterization of Multiple Allosteric Binding Sites on the Free Fatty Acid 1 Receptor |
| 研究小脑在慢步态适应中的控制作用：从分带行走的预测模拟中获得的见解 |
Fleischmann, S. |
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N/A |
Investigating cerebellar control in slow gait adaptations: Insights from predictive simulations of split-belt walking |
| 一个小分子增强了 arrestin-3 与 β2-肾上腺素能受体的结合 |
Kurt, H. |
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N/A |
A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor |
| 由乙酰辅酶A和S-腺苷甲硫氨酸耗竭引起的表观遗传重编程是一条进化上古老的通向恶性生长的途径。 |
Chen, Z. |
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N/A |
Epigenetic reprogramming induced by Acetyl-CoA and SAM depletion is an evolutionarily-ancient path to malignant growth |
| 耕作中的紧张关系：减少耕作强度与小麦生长和营养谷物质量的降低相关，尽管土壤生物指标有所改善 |
Waibel, M. |
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N/A |
Tensions in tillage: Reduction in tillage intensity associates with lower wheat growth and nutritional grain quality despite enhanced soil biological indicators |
| 通过基于角蛋白的水凝胶递送阿托伐他汀的抗纤维化作用 |
Carroll, E. A. |
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N/A |
Anti-fibrotic Effects of Atorvastatin Delivered via Keratin-based Hydrogels |
| 多组学整合的可视化神经网络：一项关键性综述 |
Selby, D. A. |
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N/A |
Visible neural networks for multi-omics integration: a critical review |
| 基于监督表示学习的组织特异性细胞类型注释，采用分割向量量化方法及其与单细胞基础模型的比较 |
Heryanto, Y. D. |
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N/A |
Tissue-Specific Cell Type Annotation with Supervised Representation Learning using Split Vector Quantization and Its Comparisons with Single-cell Foundation Models |
| 细胞表面拥挤是一种可调节的生物物理屏障，影响细胞间的融合。 |
Lee, D. S. W. |
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N/A |
Cell surface crowding is a tunable biophysical barrier to cell-cell fusion |
| 蛋白质语言模型识别出驱动相分离的无序、保守基序 |
Zhang, Y. |
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N/A |
Protein Language Model Identifies Disordered, Conserved Motifs Driving Phase Separation |
| 关于革兰氏阴性菌中周质伴侣作为蛋白质折叠和转运调节因子的机制性见解 |
Haldar, S. |
PDF |
N/A |
Mechanistic Insights into Periplasmic Chaperones as Regulators of Protein Folding and Translocation in Gram-Negative Bacteria |
| 表观遗传调控因子BAP1的破坏会驱动染色质重塑，从而促使具有乳腺癌干细胞特性和异常糖基化的细胞出现。 |
Araujo, M. G. d. S. |
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N/A |
Disruption of the epigenetic regulator BAP1 drives chromatin remodeling leading to the emergence of cells with breast cancer stem cell properties and aberrant glycosylation. |
| 钠-葡萄糖共转运蛋白2抑制剂托格列净通过激活Kv通道、SERCA泵以及sGC/cGMP通路来诱导血管舒张。 |
Park, W. S. |
PDF |
N/A |
The sodium-glucose cotransporter 2 inhibitor tofogliflozin induces vasodilation by activating Kv channels, the SERCA pump, and the sGC/cGMP pathway |
| 一种肠道微生物-肌肉轴，通过调节秀丽隐杆线虫的线粒体分裂，保护其免受与年龄相关的运动能力下降。 |
Dennis, N. |
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N/A |
A gut-microbiota-muscle axis that protects against age-related motor decline by regulating mitochondrial fission in C. elegans |
| 锌是精子特异性钾通道（Slo3）功能的关键调节因子 |
Andriani, R. T. |
PDF |
N/A |
Zinc is a Key Regulator of the Sperm-Specific K+ Channel (Slo3) Function |
| 一种用于预测真菌物种表观遗传学基因表达的混合机器学习模型 |
Weinstock, L. |
PDF |
N/A |
A hybrid machine learning model for predicting gene expression from epigenetics across fungal species |
| 大肠杆菌转录因子通过一种普遍的、稳态的机制调节启动子活性。 |
Parisutham, V. |
PDF |
N/A |
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism |
| 单次使用赛洛西宾后大鼠前额叶皮层网络的短期和长期重组 |
Purple, R. J. |
PDF |
N/A |
Short- and long-term reconfiguration of rat prefrontal cortical networks following single doses of psilocybin |
| 基于网络的β淀粉样蛋白病理预测认知正常老年人的后续认知下降 |
He, H. |
PDF |
N/A |
Network-based amyloid-beta pathology predicts subsequent cognitive decline in cognitively normal older adults |
| 洪堡企鹅（Spheniscus humboldti, Meyen, 1834）在秘鲁钦博特的埃尔费罗尔湾的出现及其保护策略 |
Loayza-Aguilar, R. E. |
PDF |
N/A |
Occurrence of the Humboldt Penguin (Spheniscus humboldti, Meyen, 1834) in El Ferrol Bay, Chimbote, Peru, and strategies for its conservation |
| 核小体动力学使活体人细胞中的异染色质变得可及。 |
Prajapati, H. K. |
PDF |
N/A |
Nucleosome dynamics render heterochromatin accessible in living human cells |
| 一种新型甘露聚糖特异性嵌合抗原受体M-CAR能够引导T细胞与念珠菌属菌丝及米根霉孢子相互作用。 |
Guimaraes, J. G. |
PDF |
N/A |
A novel Mannan-specific chimeric antigen receptor M-CAR redirects T cells to interact with Candida spp. hyphae and Rhizopus oryzae spores |
| Galectin-1通过调节糖酵解来调控肝细胞癌对热消融的反应。 |
Nguyen, T. |
PDF |
N/A |
Galectin-1 Modulates Hepatocellular Carcinoma Response to Thermal Ablation Through Regulating Glycolysis |
| 揭示欧洲蝰蛇及其毒液的进化历史：一种多组学方法 |
Talavera, A. |
PDF |
N/A |
Unveiling the evolutionary history of European vipers and their venoms from a multi-omic approach |
| 水生理学核磁共振揭示了神经组织中稳态水交换的机制 |
Williamson, N. H. |
PDF |
N/A |
Hydrophysiology NMR reveals mechanisms of steady-state water exchange in neural tissue |
| 多巴胺通过D1样受体调节间隙连接耦合，调控AII无长突细胞的膜电位和甘氨酸释放。 |
Strazza Junior, P. |
PDF |
N/A |
Dopamine regulates the membrane potential and glycine release of AII amacrine cells via D1-like receptor modulation of gap junction coupling. |
| 免疫-RCA在印刷糖阵列上高灵敏度检测ABO血型抗体的应用 |
Kornilova, E. E. |
PDF |
N/A |
The applying of immuno-RCA for the high-sensitivity detection of the ABO blood group antibodies on the printed glycoarray |
| 关于塑造淡水碎屑食物网的流域土地覆盖变化的综合分析 |
Oester, R. |
PDF |
N/A |
A global synthesis on land-cover changes in watersheds shaping freshwater detrital food webs |
| 三种新海洋纤毛虫物种的形态学和分子系统发育特征 |
Phanprasert, Y. |
PDF |
N/A |
Morphological and Molecular Phylogenetic Characterization of Three New Marine Goniomonad Species |
| 动物中高累积的流感病毒滴度与显著的疾病致死率表明，在致死率与传播性之间可能存在一种权衡关系。 |
Gouveia, A. S. |
PDF |
N/A |
High cumulative viral titers of influenza virus in animals with significant disease fatality rates indicate a potential trade-off between fatality and transmissibility |
| 选择对生产代价高昂的毒素的强度随着生长速率的增加而增强。 |
Bisesi, A. |
PDF |
N/A |
The strength of selection for costly toxin production increases with growth rate. |
| 血管紧张素肽增强SARS-CoV-2刺突蛋白与其宿主细胞受体的结合 |
Oliveira, K. X. |
PDF |
N/A |
Angiotensin peptides enhance SARS-CoV-2 spike protein binding to its host cell receptors |
| H2B.W2是一种特异性于精母细胞的组蛋白变体，它破坏了核小体的稳定性并降低了染色质的压缩程度。 |
NGUYEN, T. T. |
PDF |
N/A |
H2B.W2, a Spermatocytes-specific Histone Variant, disrupts nucleosome stability and reduces chromatin compaction |
| 库欣综合征缓解后股骨颈的生物力学弹性：基于QCT的有限元模型的比较分析 |
Soudah Prieto, E. |
PDF |
N/A |
Biomechanical resilience of the femoral neck post-remission of Cushing's Syndrome: a comparative analysis using QCT-based Finite Element models |
| 计算机模拟比较恶性疟原虫新蛋白质作为抗疟疾候选药物靶点 |
Surya, A. M. G. |
PDF |
N/A |
In silico Comparison of Novel Proteins from Plasmodium Falciparum as Candidate Drug Targets against Malaria |
| SARS-CoV2变异过程中RBD/hACE2界面微妙变化的分子动力学研究 |
Gheeraert, A. |
PDF |
N/A |
Subtle changes at the RBD/hACE2 interface during SARS-CoV2 variant evolution: a molecular dynamics study |
| 利用Nanoendoscopy-AFM直接压痕技术探测纳米力学揭示了癌细胞中的核弹性转变 |
Ichikawa, T. |
PDF |
N/A |
Probing nanomechanics by direct indentation using Nanoendoscopy-AFM reveals the nuclear elasticity transition in cancer cells |
| COVID-19中肺动脉重构的组织病理学评估 |
Gychka, S. G. |
PDF |
N/A |
Histopathological Evaluation of Pulmonary Arterial Remodeling in COVID-19 |
| SUMO E1共价别构抑制剂通过MAT2A-AdoMetDC轴调节多胺合成。 |
Zhang, S. |
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N/A |
SUMO E1 covalent allosteric inhibitors modulate polyamine synthesis via the MAT2A-AdoMetDC axis |
| 一种新颖且稳健的方法，用于评估健康和患病冷冻心脏组织中的线粒体（功能障碍）功能 |
Hu, L. |
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N/A |
A novel and robust method for assessing mitochondrial (dys)function in healthy and diseased frozen cardiac tissue |
| 基于数据的细胞类型导向网络校正组合疗法在阿尔茨海默病中的发现 |
Li, Y. |
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N/A |
Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease |
| 使用一维卷积神经网络对视觉意象和想象语音脑机接口进行分类 |
Le, D. |
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N/A |
Classification of Visual Imagery and Imagined Speech EEG based Brain Computer Interfaces using 1D Convolutional Neural Network |
| 成纤维细胞和壁细胞亚群在神经性疼痛模型中的作用。 |
Villa-Hernandez, S. |
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N/A |
A role for fibroblast and mural cell subsets in models of neuropathic pain. |
| 改变的嘌呤能信号传导和CD8+ T细胞功能失调在STAT3功能获得综合征中的表现 |
Duran, J. S. C. |
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N/A |
Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF Syndrome |
| SARS-CoV-2 Nsp14与Tollip结合，激活促炎性信号通路，同时下调干扰素α和干扰素γ受体。 |
Thakur, N. |
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N/A |
SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon alpha and interferon gamma receptors |
| 内源性靶向微RNA降解位点簇引发特定微RNA家族的降解 |
Hiers, N. M. |
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N/A |
An endogenous cluster of target-directed microRNA degradation sites induces decay of distinct microRNA families |
| 通过实验进化揭示的性别分配权衡及其遗传结构 |
Gerchen, J. F. |
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N/A |
Sex-allocation trade-offs and their genetic architecture revealed by experimental evolution |
| 染色体的可塑性可以推动细菌的快速适应。 |
Vega-Cabrera, L. |
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N/A |
Chromosomal plasticity can drive rapid adaptation in bacteria |
| 雄性小鼠没有对糖的偏好行为。 |
Pan, T. |
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N/A |
Male Mice Have no Sugar-preference Behavior |
| 从整合的转录组数据集中推断基因-通路关联：用于嗜热四膜虫的交互式基因网络浏览器 |
Bertagna, M. A. |
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N/A |
Inferring gene-pathway associations from consolidated transcriptome datasets: an interactive gene network explorer for Tetrahymena thermophila |
| 运动想象和实际执行激活了相似的手指表征，这些表征在时间上是空间一致的。 |
Odermatt, I. A. |
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N/A |
Motor imagery and execution activate similar finger representations that are spatially consistent over time |
| 肽信息压缩技术（PICT）：治疗性肽发现的新前沿 |
Wang, H. |
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N/A |
Peptide Information Compression Technology (PICT): A New Frontier in Therapeutic Peptide Discovery |
| 两种蜜蜂物种——西方蜜蜂（Apis mellifera）和日本东方蜜蜂（Apis cerana japonica）的综合表达数据 |
Yokoi, K. |
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N/A |
Comprehensive expression data for two honey bee species, Apis mellifera and Apis cerana japonica |
| Cuf1转录因子富含半胱氨酸的结构域对于高铜胁迫感应和真菌毒力是必需的。 |
Probst, C. |
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N/A |
A cysteine-rich domain of the Cuf1 transcription factor is required for high copper stress sensing and fungal virulence |
| 六种细菌暴露于六类抗生素下的共敏感性和交叉抗性 |
Wang, X. H. |
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N/A |
Collateral sensitivity and cross resistance in six species of bacteria exposed to six classes of antibiotics |
| 酶促差向异构化在卡痛中的单萜吲哚生物碱 |
McDonald, A. |
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N/A |
Enzymatic epimerization of monoterpene indole alkaloids in Kratom |
| PEX1G843D在过氧化物酶体生物发生中仍保持功能，但会被蛋白酶体迅速降解。 |
Sheedy, C. J. |
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N/A |
PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome |
| 数据非依赖性采集结合电子活化解离技术，用于深入解析羟基脂肪酸酯的结构 |
Kurizaki, Y. |
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N/A |
Data-independent acquisition coupled with electron-activated dissociation for in-depth structure elucidation of fatty acid ester of hydroxy fatty acids |
| 开发一种增强的抗泛N-甲酰甲硫氨酸特异性抗体 |
Kim, D. |
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N/A |
Development of an enhanced anti-pan-N-formylmethionine-specific antibody |
| SETD2协同转录的H3K36甲基化的分子机制 |
Walshe, J. L. |
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N/A |
Molecular mechanism of co-transcriptional H3K36 methylation by SETD2 |
| CRISPR编辑的DPSCs，持续表达BDNF，增强受损牙齿的牙本质再生 |
Kim, J. H. |
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N/A |
CRISPR-Edited DPSCs, Constitutively Expressing BDNF Enhance Dentin Regeneration in Injured Teeth |
| PhyloCNN：在系统动力学和多样化研究中，通过改进树的表示和神经网络架构来提升从树中进行深度学习的效果 |
Perez, M. F. |
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N/A |
PhyloCNN: Improving tree representation and neural network architecture for deep learning from trees in phylodynamics and diversification studies |
| 人类DNA中进一步的古代内源性逆转录病毒变种 |
Frith, M. |
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N/A |
Further varieties of ancient endogenous retrovirus in human DNA |
| 解卷积依赖TCR与不依赖TCR的激活对于通过AIM测定进行可靠的抗原特异性CD4+ T细胞表征至关重要。 |
Zheng, M. Z. M. |
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N/A |
Deconvoluting TCR-dependent & -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay |
| 通过黄蝶呤生物合成途径基因调控黄曲霉H-1形态、分生孢子生成及紫色色素合成 |
Ran, Y. |
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N/A |
Regulation of Fungal Morphology, Conidiogenesis and Violet Pigment Synthesis by the Betalain Biosynthesis Pathway Genes in Aspergillus sydowii H-1 |
| 零价硫是同化型亚硫酸盐还原酶的产物，也是半胱氨酸合酶的底物。 |
Liu, H. |
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N/A |
Zero valent sulfur is the product of assimilatory sulfite reductase and a substrate of cysteine synthase |
| 脑心肌炎病毒非结构蛋白2C通过降解NDP52自噬蛋白以促进其自身存活 |
Mo, R. |
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N/A |
Encephalomyocarditis virus non-structural protein 2C degrades NDP52 autophagy protein to promote its own survival |
| 利用PTasRNA技术通过pMEGA质粒靶向清除改造海洋假交替单胞菌TAC125 |
Severino, A. |
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N/A |
Engineering the Marine Pseudoalteromonas haloplanktis TAC125 via pMEGA Plasmid Targeted Curing Using PTasRNA Technology |
| 多组学映射肠道微生物群在孕酮代谢中的作用 |
Mong, G.-J. B. |
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N/A |
Multi-Omics Mapping of Gut Microbiota's Role in Progesterone Metabolism |
| RNA病毒的发现揭示了主要葡萄园害虫——欧洲葡萄蛾（Lobesia botrana）的病毒组情况。 |
Debat, H. J. |
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N/A |
RNA virus discovery sheds light on the virome of a major vineyard pest, the European grapevine moth (Lobesia botrana) |
| 通过-MaP和-JuMP揭示的由倒置Alu介导的反向剪接的结构决定因素 |
Waldern, J. M. |
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N/A |
Structural determinants of inverted Alu-mediated backsplicing revealed by -MaP and -JuMP |
| 对PBMCs和供体匹配的iPSCs中DNA甲基化的表征显示，在干细胞重编程过程中，甲基化被重置。 |
Reed, X. |
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N/A |
Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming |
| 癌症相关生物标志物的多重甲基化特异性qPCR的系统设计 |
Wang, J. |
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N/A |
Systematic Design of Multiplex Methylation-Specific qPCR for Cancer-Related Biomarkers |
| 利用基因组技术在多花黄精中发现了二苯乙烯类基因簇 |
Jiang, J. |
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N/A |
Genome-enabled stilbenoid gene cluster discovery in Pleuropterus multiflorus |
| 在Dictyostelium中，细胞外腺苷脱氨作用促进了顶端组织者的发育。 |
Hathi, P. |
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N/A |
Extracellular adenosine deamination primes tip organizer development in Dictyostelium |
| 一个用于定量分析遗传缓冲的数学框架 |
Karagiannis, J. |
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N/A |
A Mathematical Framework for the Quantitative Analysis of Genetic Buffering |
| 通过化学诱导染色体相互作用进行Hi-C校准 |
Li, Y. |
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N/A |
Hi-C Calibration by Chemically Induced Chromosomal Interactions |
| 哺乳动物蛋白MTCH1可以作为插入酶发挥作用。 |
Dimogkioka, A. R. |
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N/A |
The mammalian protein MTCH1 can function as an insertase |
| 在E.coli中表达TNFR1 R347A、MyD88和IRAK4死亡结构域，随后进行纯化并对其中的TNFR1 R347A死亡结构域进行生物物理特性分析。 |
Przytulski, K. |
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N/A |
Expression screen of TNFR1 R347A, MyD88, IRAK4 death domains in E. coli followed by purification and biophysical characterization of TNFR1 R347A death domain |
| 制药放行分析中仪器变更的通用研究设计 |
Ries, A. B. |
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N/A |
Universal Study Design for Instrument Changes in Pharmaceutical Release Analytics |
| 基于点击化学的双向生物正交方法用于检测和鉴定骨关节炎研究中的蛋白质赖氨酸丙二酰化 |
Binoy, A. |
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N/A |
A click chemistry-based biorthogonal approach for the detection and identification of protein lysine malonylation for osteoarthritis research |
| 通过腺相关病毒递送实现小鼠体细胞组织的线粒体腺苷碱基编辑 |
Mutti, C. D. |
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N/A |
Mitochondrial adenine base editing of mouse somatic tissues via adeno-associated viral delivery |
| LMX1B错义扰动调节元件足迹破坏了5-羟色胺能前脑轴突的分枝结构。 |
Eastman, B. A. |
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N/A |
LMX1B missense-perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization |
| 数据驱动的突触分类揭示了谷氨酸受体组成的逻辑 |
Micheva, K. D. |
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N/A |
Data-driven synapse classification reveals a logic of glutamate receptor composition |
| 甲状腺激素作为计时器，调控小鼠新皮层中小清蛋白神经元的产后成熟过程。 |
Ren, J. |
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N/A |
Thyroid hormones act as a timer for the postnatal maturation of parvalbumin neurons in mouse neocortex |
| 由于斑马鱼中Pax9基因突变导致的面部中部凹陷和面部附属器官缺失 |
Paudel, S. |
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N/A |
Midfacial retrusion and loss of facial appendages caused by mutation of Pax9 in zebrafish |
| 在新石器时代的卡塔许尤克遗址中，通过古代DNA保存反映出的特定年龄段的埋葬习俗 |
Kücükakdag Dogu, A. |
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N/A |
An age-specific burial practice reflected in ancient DNA preservation in Neolithic Catalhöyük |
| 在家族内进行的GWAS（全基因组关联研究）并未能改善跨群体预测准确性的下降。 |
Zhang, L. |
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N/A |
Within-Family GWAS does not Ameliorate the Decline in Prediction Accuracy across Populations |
| 单个神经元的多样性支持了视觉皮层通路沿线的区域功能特化。 |
Feyerabend, M. |
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N/A |
Single neuron diversity supports area functional specialization along the visual cortical pathways |
| 人类海马体中的θ震荡组织了目标距离编码 |
Huang, Z. |
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N/A |
Human Hippocampal Theta Oscillations Organise Distance to Goal Coding |
| GABA、谷氨酸动态以及在具有幻觉特征的精神病患者进行认知处理期间观察到的BOLD信号 |
Craven, A. R. |
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N/A |
GABA, Glutamate dynamics and BOLD observed during cognitive processing in psychosis patients with hallucinatory traits |
| 围产期血清素信号传导动态地影响皮质GABA能回路的发育，其结果对终身的感官编码产生影响。 |
Ocana-Santero, G. |
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N/A |
Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding |
| Dlx5/6在协调哺乳动物发声和听觉器官发育中的多效性功能 |
Sanchez-Garrido, F. |
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N/A |
Pleiotropic function of Dlx5/6 in coordinating the development of mammalian vocal and auditory organs |
| 高度多样化灵长类动物的岛屿殖民基因组特征 |
Colmonero-Costeira, I. |
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N/A |
Genomic signatures of island colonization in highly diverse primates |