| 数学和生物学上一致的存在-缺失成对指数框架 |
Sizling, A. L. |
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Mathematically and biologically consistent framework for presence-absence pairwise indices |
| 非经典端粒酶逆转录酶通过STAT5调控主动脉瓣细胞的成骨性重编程 |
Cuevas, R. A. |
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Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5 |
| Stu2在动粒中具有一个独立于调节微管动力学的重要功能。 |
Abouelghar, A. A. |
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Stu2 has an essential kinetochore role independent of regulating microtubule dynamics |
| Hermansky-Pudlak综合征中失调的肺泡上皮细胞祖细胞功能与特性 |
Wang, J. Y. |
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Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome |
| 蜜月阴暗面：通过基因组学视角重构亚洲与欧洲玫瑰育种历史 |
Leroy, T. |
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Dark side of the honeymoon: reconstructing the Asian x European rose breeding history through the lens of genomics |
| 个体幸福感差异得到了一系列可分离的、与自我注意和视觉注意相关的脑网络的支持。 |
Ma, Y. |
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Individual differences in wellbeing are supported by separable sets of co-active self- and visual-attention-related brain networks |
| IgDesign：利用反向折叠技术针对多种治疗性抗原进行体外验证的抗体设计 |
Shanehsazzadeh, A. |
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IgDesign: In vitro validated antibody design against multiple therapeutic antigens using inverse folding |
| 使用由分支概率参数化的树分布进行精确的贝叶斯系统发育点估计 |
Berling, L. |
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Accurate Bayesian phylogenetic point estimation using a tree distribution parameterized by clade probabilities |
| 三部分ATP非依赖性周质（TRAP）转运蛋白结合Neu5Ac的分子决定因素 |
Goyal, P. |
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Molecular determinants of Neu5Ac binding to tripartite ATP independent periplasmic (TRAP) transporter |
| 现实世界任务中的反馈操作不会改变运动学习机制 |
Nardi, F. |
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Motor Learning Mechanisms are not modified by Feedback Manipulations in a Real-World Task |
| 在产生烟灰的气候灾难后，谷类作物地方品种的适应不良 |
McLaughlin, C. |
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Maladaptation in cereal crop landraces following a soot-producing climate catastrophe |
| 大肠杆菌在半干银、铜、不锈钢和玻璃表面上的实验进化 |
Rosenberg, M. |
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Experimental evolution of Escherichia coli on semi-dry silver, copper, stainless steel, and glass surfaces |
| Lag3和PD-1通路在早期CD4+ T细胞激活过程中调控依赖于NFAT的TCR信号传导程序。 |
Sheriff, L. |
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Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation |
| 通过招募关键免疫细胞在水凝胶储库中生成炎症微环境，可提高mRNA疫苗的效力。 |
Meany, E. L. |
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Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines |
| 成像空间转录组学揭示了转基因α-突触核病模型中病理易感性的分子模式 |
Horan-Portelance, L. |
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Imaging spatial transcriptomics reveals molecular patterns of vulnerability to pathology in a transgenic α-synucleinopathy model |
| Tunturi病毒分离株和宏基因组组装的病毒基因组为北极冻原土壤中酸杆菌门的病毒组提供了深入了解。 |
Demina, T. |
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Tunturi virus isolates and metagenome-assembled viral genomes provide insights into the virome of Acidobacteriota in Arctic tundra soils |
| 孤儿基因对于果蝇（Drosophila melanogaster）中精子高效进入卵子是必不可少的。 |
Guay, S. Y. |
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An orphan gene is essential for efficient sperm entry into eggs in Drosophila melanogaster |
| 转录因子TCF21在肾脏发育过程中对于Foxd1+基质祖细胞的细胞命运决定是必需的。 |
Finer, G. |
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The transcription factor TCF21 is necessary for adoption of cell fates by Foxd1+ stromal progenitors during kidney development |
| 人类和其他猿类端粒到端粒基因组中的非典型DNA |
Smeds, L. |
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Non-canonical DNA in human and other ape telomere-to-telomere genomes |
| 通过考虑树突计算来克服运动传感器模型的局限性 |
Luna, R. |
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Overcoming the limitations of motion sensor models by considering dendritic computations |
| 评估《昆明-蒙特利尔全球生物多样性框架》监测框架的覆盖范围及填补空白的机遇。 |
Affinito, F. |
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Assessing coverage of the Monitoring Framework of the Kunming-Montreal Global Biodiversity Framework and opportunities to fill gaps. |
| 一种基于化合物生物活性谱的条件扩散模型，用于预测高内涵图像 |
Cook, S. |
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A diffusion model conditioned on compound bioactivity profiles for predicting high-content images |
| 测试的测试：利用基于连接组学的预测模型揭示标准化测试和临床症状所反映的系统 |
Samardzija, A. |
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Testing the Tests: Using Connectome-Based Predictive Models to Reveal the Systems Standardized Tests and Clinical Symptoms Are Reflecting |
| 因果枢纽：复杂疾病中遗传异质性和变异发现的结构化方法 |
Shaw, C. A. |
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The Causal Pivot: A Structural Approach to Genetic Heterogeneity and Variant Discovery in Complex Diseases |
| 多尺度基于云的神经电生理分析与可视化管道 |
Geng, J. |
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Multiscale Cloud-based Pipeline for Neuronal Electrophysiology Analysis and Visualization |
| UniversalEPI：利用注意力机制解码稀有和未探索细胞类型中的染色质相互作用 |
Grover, A. |
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UniversalEPI: Harnessing Attention Mechanisms to Decode Chromatin Interactions in Rare and Unexplored Cell Types |
| SPE-CZE-MS 能够定量测定磷酸化肽的仄摩尔浓度。 |
Serrano, L. R. |
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SPE-CZE-MS quantifies zeptomole concentrations ofphosphorylated peptides |
| 抗体通过配体模拟和变构干扰来破坏细菌的粘附。 |
Hvorecny, K. L. |
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Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference |
| 解读结直肠癌与肝细胞相互作用：一种用于探究肝脏-肿瘤微环境中代谢交叉对话的多组学平台 |
Nelson, A. B. |
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Deciphering Colorectal Cancer-Hepatocyte Interactions: A Multiomic Platform for Interrogation of Metabolic Crosstalk in the Liver-Tumor Microenvironment |
| 静息状态下人体骨骼肌分子特征的性别二态性及其对急性运动和耐力训练的反应 |
Dreher, S. I. |
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Sexual dimorphism in molecular profiles of resting human skeletal muscle and the response to acute exercise and endurance training |
| 叶绿体代谢中三种酶的同时过表达未能提高二氧化碳同化或生物量。 |
Lemonnier, P. |
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Simultaneous Overexpression of Three Enzymes of Chloroplast Metabolism Fails to Improve CO2 Assimilation or Biomass. |
| 鉴定髓样蛋白激酶C-ε为一个新型抗动脉粥样硬化基因 |
Binrouf, R. H. |
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Identification of Myeloid Protein Kinase C - Epsilon as a Novel Atheroprotective Gene |
| 椎间盘细胞通过受体重排和代谢酶补充维持微环境及细胞稳态的小型细胞外囊泡 |
Samanta, A. |
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Small Extracellular Vesicles by Nucleus Pulposus Cells Maintain Niche and Cell Homeostasis via Receptor Shuffling and Metabolic Enzyme Supplements |
| 14-3-3 epsilon通过抑制Plk1和Separase的活性，抑制了中心粒的过早脱离。 |
Jaiswal, M. A. |
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14-3-3 epsilon inhibits premature centriole disengagement by inhibiting the activity of Plk1 and Separase. |
| 长读段测序的Caviid γ疱疹病毒1：编译全面的RNA图谱 |
Boldogkoi, Z. |
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Long-read Transcriptomics of Caviid Gammaherpesvirus 1: Compiling a Comprehensive RNA Atlas |
| 泛癌N-糖蛋白质组图谱揭示FAT2为头颈癌的治疗靶点 |
Govindarajan, M. |
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Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers |
| 在英国初级诊疗实践中诊断为血管肉瘤的犬的生存时间和预后因素 |
Taylor, C. |
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Survival time and prognostic factors in dogs diagnosed with haemangiosarcoma in UK first opinion practice |
| M102，一种用于肌萎缩侧索硬化症神经保护的NRF2和HSF-1双重激活剂。 |
Shaw, P. J. |
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M102, a combined NRF2 and HSF-1 activator for neuroprotection in amyotrophic lateral sclerosis. |
| MMETHANE：一种可解释的人工智能，用于从微生物组组成和代谢组学数据预测宿主状态 |
Dawkins, J. J. |
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MMETHANE: interpretable AI for predicting host status from microbial composition and metabolomics data |
| 利用超高通量辐射快速灭菌临床血浆分离术血液制品 |
Melemenidis, S. |
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Rapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation |
| 伤寒沙门氏菌的伤寒毒素在急性伤寒热期间引发宿主的抗菌反应。 |
Srour, S. |
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Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever |
| 细胞壁合成的撞击逃逸：LpoB通过一个保守的变构开关短暂结合并激活PBP1b。 |
Shlosman, I. |
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The hit-and-run of cell wall synthesis: LpoB transiently binds and activates PBP1b through a conserved allosteric switch. |
| CarSR双组分系统直接调控radD表达，作为全局调节因子感知具核梭杆菌中的细菌共聚集现象 |
G C, B. |
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The CarSR Two-Component System Directly Controls radD Expression as a Global Regulator that Senses Bacterial Coaggregation in Fusobacterium nucleatum |
| 核小体中Set2和RNAPII延伸复合体介导的转录偶联H3K36三甲基化的结构基础 |
Kujirai, T. |
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Structural basis of transcription-coupled H3K36 trimethylation by Set2 and RNAPII elongation complex in the nucleosome |
| β-心脏肌球蛋白在超松弛状态和无序松弛状态之间的动力学 |
Cail, R. C. |
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Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states |
| 氧化还原依赖的结合和构象平衡调控活细胞中NAD(P)H的荧光衰减 |
Blacker, T. S. |
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Redox-dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells |
| 工程化脯氨酰羟化酶依赖的蛋白质水解作用使得在植物中对缺氧反应进行正交控制成为可能 |
Shukla, V. |
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Engineering prolyl hydroxylase-dependent proteolysis enables the orthogonal control of hypoxia responses in plants |
| 一种互利共生模式的细菌通过第六型分泌系统对非共生宿主具有致命性。 |
Gaddy, K. E. |
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A mutualistic model bacterium is lethal to non-symbiotic hosts via the type VI secretion system |
| 通过邻近标记蛋白质组学研究上皮细胞细菌感染过程中CD9相互作用组的动力学 |
Wolverson, P. A. |
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Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics |
| 沙门氏菌多突变体能够有效识别SPI-2效应蛋白在肠道炎症和全身定殖中的功能 |
Newson, J. P. M. |
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Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization |
| Sp140L是一种新型的疱疹病毒限制因子。 |
Cable, J. M. |
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Sp140L Is a Novel Herpesvirus Restriction Factor |
| MaAsLin 3：优化并扩展元基因组关联发现的广义多元线性模型 |
Nickols, W. A. |
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MaAsLin 3: Refining and extending generalized multivariable linear models for meta-omic association discovery |
| 多重碱基编辑BCL11A调控元件以治疗镰状细胞病 |
Fontana, L. |
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Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease |
| 古菌基因组中的II类内含子与真核剪接体内含子的进化起源 |
Mattick, J. S. A. |
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Group II Introns in Archaeal Genomes and the Evolutionary Origin of Eukaryotic Spliceosomal Introns |
| 利用橙色发光碳纳米点作为荧光探针的超分辨率线粒体网络结构成像 |
Nandi, C. K. |
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Super Resolved Structural Imaging of Mitochondrial Network using Orange Emissive Carbon Nanodot as Fluorescent Probe |
| 特定磷酸化模式在Tau-R4寡聚化中的作用 |
Bressler, S. G. |
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The role of specific phosphorylation patterns in the oligomerization of Tau-R4 |
| YibN是一种与YidC相互作用的真正互作蛋白，与膜蛋白插入和膜脂质生成有关。 |
Zhao, Z. |
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YibN, a bona fide interactor of YidC with implications in membrane protein insertion and membrane lipid production |
| 亮氨酸氨肽酶LyLAP能够促进溶酶体对膜蛋白的降解。 |
Jain, A. |
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Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins |