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BioRxiv 2024-12-15 Papers

标题 作者 PDF链接 代码仓库 Title
默认模式网络连接性预测个体在长期遗忘中的差异:存储衰减的证据,而非提取失败 Xu, Y. PDF N/A Default Mode Network Connectivity Predicts Individual Differences in Long-Term Forgetting: Evidence for Storage Decay, not Retrieval Failure
光环:单细胞多组学数据的层次因果建模 Mao, H. PDF N/A HALO: Hierarchical Causal Modeling for Single Cell Multi-Omics Data
糖原贮积症1a型中与疾病相关的细胞记忆编程 Sprecher, U. PDF N/A Disease-associated programming of cell memory in glycogen storage disorder type 1a
植物基因组的高效组装:以毛茛属(毛茛科)为例,探讨其进化意义 Karbstein, K. PDF N/A Efficient assembly of plant genomes: A case study with evolutionary implications in Ranunculus (Ranunculaceae)
蛋白质语言模型监督的可扩展方法,用于多样化和可设计的蛋白质基序-支架结构,基于GPDL Zhang, B. PDF N/A Protein Language Model Supervised Scalable Approach for Diverse and Designable Protein Motif-Scaffolding with GPDL
MIOSTONE:利用自适应分类神经网络建立微生物组与性状的关联模型 Jiang, Y. PDF N/A MIOSTONE: Modeling microbiome-trait associations withtaxonomy-adaptive neural networks
探索转折(ExploreTurns):一种用于探索、分析和分类蛋白质中beta转折和结构化环的网络工具;应用于beta凸起和Schellman环、Asx螺旋帽、beta发夹以及其他氢键连接的基序。 Newell, N. E. PDF N/A ExploreTurns: A web tool for the exploration, analysis, and classification of beta turns and structured loops in proteins; application to beta-bulge and Schellman loops, Asx helix caps, beta hairpins and other hydrogen-bonded motifs
通过碱基编辑修复番茄花调控基因中的有害驯化变异 Glaus, A. N. PDF N/A Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing
一种自我关注偏向的神经特征 Geisler, D. J. PDF N/A A Neural Signature of the Bias Towards Self-Focus
MicroRNA-26b 在保护小鼠免受MASH(代谢相关脂肪性肝炎)发展方面具有作用,并且可以通过脂质纳米颗粒进行有效靶向。 Peters, L. PDF N/A MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles.
在不同黄鲈(Perca flavescens)种群中,有效群体大小变化背景下并行的遗传适应 Yin, X. PDF N/A Parallel genetic adaptation amidst a background of changing effective population sizes in divergent yellow perch (Perca flavescens) populations
更强的蝙蝠捕食压力和较弱的环境限制预示着蛾子尾巴更长。 Rubin, J. PDF N/A Stronger bat predation and weaker environmental constraints predict longer moth tails
一种长寿命、跨大陆迁徙鸟类的扩散、成熟和繁殖 Mirski, P. PDF N/A Dispersal, maturation and recruitment in a long-lived, trans-continentally migrating bird
一种VLP疫苗平台,包含乙型肝炎病毒的核心蛋白与N端抗原捕获。 Fatema, K. PDF N/A A VLP vaccine platform comprising the core protein of hepatitis B virus with N-terminal antigen capture
细胞周期振荡器和纺锤体长度决定了果蝇胚胎中染色体分离的速度。 Xu, Y. PDF N/A The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos
通过小脑和基底神经节的协同合作实现协同强化学习 Yohida, T. PDF N/A Synergistic reinforcement learning by cooperation of the cerebellum and basal ganglia
PhyloMix:通过系统发育混合增强技术提升微生物组-性状关联预测 Jiang, Y. PDF N/A PhyloMix: Enhancing microbiome-trait association prediction through phylogeny-mixing augmentation
弱监督向量量化在全切片图像分类中的应用 Shen, D. PDF N/A Weakly Supervised Vector Quantization for Whole Slide Image Classification
慈鲷鱼面部表情的社会效益:检验面部集中假设 Satoh, S. PDF N/A Social benefits of facial experssion in a cichlid fish: Testing the face concentration hypothesis
顶端网格蛋白包被的凹陷控制微绒毛生长的位置、时间及规模。 Perkins, O. L. PDF N/A Apical clathrin-coated pits control the location, timing, and scale of microvillar growth
情境依赖的NMDA受体功能障碍预测携带人GluN1变异的小鼠的癫痫治疗效果 Venkatesan, S. PDF N/A Context-dependent NMDA receptor dysfunction predicts seizure treatment in mice with human GluN1 variant
量化生物模式形成的复杂性:通过复杂性度量的新视角 Riedel, J. H. R. PDF N/A Quantifying the intricacies of biological pattern formation: A new perspective through complexity measures
全息层析显微镜揭示了在血管内皮化过程中,内皮细胞的无标记定量动态变化。 Leineweber, W. D. PDF N/A Holotomographic microscopy reveals label-free quantitative dynamics of endothelial cells during endothelialization
人类疾病机制的基础模型在罕见病和常见病中的表示学习 Ravandi, B. PDF N/A Representation Learning of Human Disease Mechanisms for a Foundation Model in Rare and Common Diseases
一氧化氮通过S-亚硝基化调节Rab5的吞噬作用 Hagiwara, M. PDF N/A Nitric oxide regulates phagocytosis through S-nitrosylation of Rab5
用于晶体衍射数据质量评估的I/σI与{Rmerg, Rmeas, Rpim, CC1/2}关系图 Fu, Z. PDF N/A I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation
特定磷酸化模式在Tau-R4寡聚化中的作用 Bressler, S. G. PDF N/A The role of specific phosphorylation patterns in the oligomerization of Tau-R4
野生东部黑猩猩在呼叫声中的性别差异 Holden, E. PDF N/A Sex differences in pant-hoot vocalizations in wild Eastern chimpanzees
在老鼠的社会信任任务中,催产素增强了获取能力,而催产素及其拮抗剂则阻止了信任违背的学习。 Budniok, S. PDF N/A Oxytocin enhances acquisition in a social trust task in mice, whereas both oxytocin and its antagonist block trust violation learning
剖析密集皮层连接组中连线特异性的起源 Harth, P. PDF N/A Dissecting origins of wiring specificity in dense cortical connectomes
rx3基因促进了墨西哥洞穴鱼(Astyanax mexicanus)眼睛退化的演化。 Shennard, D. PDF N/A The rx3 gene contributes to the evolution of eye loss in the cavefish Astyanax mexicanus
在PDB结构模型中对结合位点的偏倚建模 Wankowicz, S. A. PDF N/A Modeling Bias Toward Binding Sites in PDB Structural Models
在小鼠中,情节性缓慢呼吸显著减少了恐惧反应。 de Sousa Abreu, R. P. PDF N/A Episodic slow breathing in mice markedly reduces fear responses
记忆和压力对选择一致性的影响 Xin, F. PDF N/A The Impact of Memory and Stress on Choice Consistency
在坐骨神经再生过程中对大鼠进行比目鱼肌H反射上调训练可改善其运动功能的恢复 Chen, Y. PDF N/A Soleus H-Reflex Up-Conditioning during Sciatic Nerve Regeneration in Rats Improves Recovery of Locomotion
大鼠、小鼠和人类在时间投资方面的有限最优性 Ott, T. PDF N/A Bounded optimality of time investments in rats, mice, and humans
利用图像分析技术对氧化石墨烯纳米颗粒的微生物还原进行稳健测量 Bennett, D. T. PDF N/A Robust measurement of microbial reduction of graphene oxide nanoparticles using image analysis
使用信号时序逻辑学习生物分子模型 Krasowski, H. PDF N/A Learning Biomolecular Models using Signal Temporal Logic
TGFβ1与RGD协同调控SMAD 2/3介导的前列腺癌细胞在生物正交构建的水凝胶中的促癌效应 Pol, M. PDF N/A TGFβ1 and RGD Cooperatively Regulate SMAD 2/3 Mediated Oncogenic Effects in Prostate Cancer Cells in Bioorthogonally Constructed Hydrogels
疾病对肾血流调节的影响:评估自调节紊乱 Maddineni, B. PDF N/A Effects of Disease on Renal Blood Flow Regulation: Assessing Autoregulation Disruption
皮层介导的肌肉对平衡干扰的反应在有和没有帕金森病的老年人中,随着干扰强度的增加而增强。 Boebinger, S. E. PDF N/A Cortically-mediated muscle responses to balance perturbations increase with perturbation magnitude in older adults with and without Parkinson's disease
在鸟类学交汇处的鸣禽DNA条形码分析揭示了显著的东西向遗传谱系分化 Tehrani, S. J. PDF N/A DNA barcoding of passerine birds at an ornithological crossroad reveals significant East-West genetic lineage divergence
草原旱獭(Marmota bobak Muller, 1776)的谱系地理学与遗传结构 Brandler, O. V. PDF N/A Phylogeography and genetic structure of the steppe marmot (Marmota bobak Muller, 1776)
淡水虾(Macrobrachium Spp.)肠道中产酶微生物的特性与鉴定 nimbalkar, d. n. PDF N/A Characterization and identification of enzyme-producing microflora isolated from the gut of freshwater Prawn, Macrobrachium Spp
暴露于低剂量壶菌(Batrachochytrium dendrobatidis)下的研究表明,极度濒危的南部corroboree蛙在抗性方面存在差异。 Davidson, M. J. PDF N/A Exposure to low doses of Batrachochytrium dendrobatidis reveals variation in resistance in the Critically Endangered southern corroboree frog
体外研究Tropilaelaps mercedesae在多种基质上的存活情况。 Gill, M. C. PDF N/A An in vitro investigation into the survival of Tropilaelaps mercedesae on a range of matrices.
在一个严格厌氧的产甲烷菌群中识别出一组苯激活酶 Toth, C. R. A. PDF N/A Identification of a Cluster of Benzene Activation Enzymes in a Strictly Anoxic Methanogenic Consortium
2018年至2019年间在菲律宾水域搁浅的鲸类动物中分离出的肠杆菌科细菌的抗性谱和基因,为揭示海洋环境中抗菌药物抗性的程度提供了线索。 Obusan, M. C. PDF N/A Resistance profiles and genes of Enterobacteriaceae from cetaceans stranded in Philippine waters from 2018-2019 provide clues on the extent of antimicrobial resistance in the marine environment
MEGA12:分子进化遗传分析适应性与绿色计算版本12 Kumar, S. PDF N/A MEGA12: Molecular Evolutionary Genetic Analysis version 12 for adaptive and green computing
结构上不同的锰感应核糖开关适体调控多种表达平台架构 Mishanina, T. PDF N/A Structurally distinct manganese-sensing riboswitch aptamers regulate diverse expression platform architectures
十八烷类作为珊瑚-腰鞭虫共生中的新兴脂质介质 Botana, M. T. PDF N/A Octadecanoids as emerging lipid mediators in cnidarian-dinoflagellate symbiosis
短RNA分子伴侣促进TDP-43蛋白形成抗聚集的构象,从而减轻神经退行性病变。 Copley, K. E. PDF N/A Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
通过代谢工程改造的Komagataella phaffii经紫外线诱变提高甲醇生产D-乳酸的效率 Inoue, Y. PDF N/A Improvement of D-lactic acid production from methanol by metabolically engineered Komagataella phaffii via ultra-violet mutagenesis
利用靶向增强超声成像量化子痫前期大鼠胎盘中分子变化 Shi, L. PDF N/A Quantifying Molecular Changes in the Preeclamptic Rat Placenta with Targeted Contrast-Enhanced Ultrasound Imaging
APHIX:使用长读长RNA测序数据进行HIV-1异构体探索的分析管道 Albert, J. L. PDF N/A APHIX: Analysis Pipeline for HIV-1 Isoform eXploration Using Long-read RNA Sequencing Data
用于器官特异性年龄和慢性疾病预测的紧凑型蛋白质组 Vladimirova, A. PDF N/A A compact protein panel for organ-specific age and chronic disease prediction
人类钙化主动脉瓣狭窄发病机制中的血浆和组织蛋白质组的性别二态性 Clift, C. L. PDF N/A Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis
与人类大腿和小腿肌肉转录组在基础状态和废用一周后调控相关的转录因子 Borzykh, A. PDF N/A Transcription factors associated with regulation of transcriptome in human thigh and calf muscles at baseline and after one week of disuse
刺激内侧黑质网状部促进持续运动恢复并对抗多巴胺耗竭小鼠的帕金森病病理生理学 Aristieta, A. PDF N/A Stimulation of the Medial SNr Promotes Sustained Motor Recovery and Counteracts Parkinsonian Pathophysiology in Dopamine Depleted Mice
通过自动微分优化脑微结构成像的实验设计 Farooq, H. PDF N/A Experimental Design Optimization for Brain Microstructure Imaging via Automatic Differentiation
4-苯基丁酸通过调节连接蛋白43的表达,限制了鼠β冠状病毒的感染性和病毒引起的脱髓鞘作用。 Kasle, G. PDF N/A 4-Phenylbutyric acid modulates Connexin 43 expression restricting murine-β-coronavirus infectivity and virus-induced demyelination
成本效益决策的计算原语 Rakocevic, L. I. PDF N/A Computational Primitives for Cost-Benefit Decision-Making
在迷幻状态期间,背外侧前额叶皮层在自我消解和情绪唤起中的作用 Coleman, C. R. PDF N/A The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State
从胸腺中出现的记忆表型Ly49+ CD8 T细胞分化为两个具有不同免疫功能的亚群。 Laubreton, D. PDF N/A Memory-Phenotype Ly49+ CD8 T emerging from the thymus develop into two subsets with distinct immune functions
益生菌补充对鲤鱼水体和肠道微生物群的影响 Jakimowicz, M. PDF N/A The impact of probiotic supplementation with effective microorganisms on water and gut microbiome of the Common carp
临床试验化合物NITD-688抑制登革病毒的机制性见解 Wang, Y. PDF N/A Mechanistic Insights into Dengue Virus Inhibition by a Clinical Trial Compound NITD-688
酵母(Saccharomyces cerevisiae)线粒体AMPylome的分析揭示了通过δ亚基调控ATP合酶偶联的机制。 Kucharczyk, R. PDF N/A Profiling of yeast Saccharomyces cerevisiae mitochondrial AMPylome reveals a regulation of ATP synthase coupling trough subunit delta
鉴定与成人一生中背外侧前额叶皮层衰老相关的环状RNA Amjadi-Moheb, F. PDF N/A Identification of Circular RNAs associated with Ageing of the Dorsolateral Prefrontal Cortex across the Adult Lifespan
通过可解释的人工智能分析飞行轨迹,区分易感和抗性冈比亚按蚊的固有特征 Qureshi, Y. PDF N/A Discrimination of inherent characteristics of susceptible and resistant strains of Anopheles gambiae by explainable Artificial Intelligence Analysis of Flight Trajectories
基于激活的高通量筛选识别出caspase-10抑制剂 Castellon, J. O. PDF N/A An activation-based high throughput screen identifies caspase-10 inhibitors
石墨烯-聚合物纳米纤维实现光诱导的干细胞衍生心肌细胞和脑类器官的电成熟 LaMontagne, E. PDF N/A Graphene-polymer Nanofibers Enable Optically Induced Electrical Maturation in Stem Cell-Derived Cardiomyocytes and Brain Organoids
ProCyon:一种用于蛋白质表型的多模态基础模型 Queen, O. PDF N/A ProCyon: A multimodal foundation model for protein phenotypes
单细胞RNA测序数据中,全面的工作流程用于等位基因特异性免疫基因定量和表达分析 Al Ajami, A. PDF N/A A comprehensive workflow for allele-specific immune gene quantification and expression analysis in single-cell RNA-seq data
主导的RDH12-视网膜色素变性损害视网膜类器官中的光感受器发育和锥体功能 Mejecase, C. PDF N/A Dominant RDH12-retinitis pigmentosa impairs photoreceptor development and cone function in retinal organoids
利用高通量表型分析技术研究高粱CRISPR-Cas9突变体的氮素响应及生长轨迹 Jin, H. PDF N/A Nitrogen response and growth trajectory of sorghum CRISPR-Cas9 mutants using high-throughput phenotyping
一个关于东部马脑炎病毒在易感宿主细胞中复制的详细动力学模型 Larkin, C. I. PDF N/A A detailed kinetic model of Eastern equine encephalitis virus replication in a susceptible host cell
旅行波增强了人类情景记忆和工作记忆中的海马-旁海马耦合 Chen, X. PDF N/A Traveling waves enhance hippocampal-parahippocampal couplings in humanepisodic and working memory
探索GBA1宿主基因型与GBA1L444P/WT小鼠模型肠道微生物群之间的关系:对帕金森病发病机制的启示 Menozzi, E. PDF N/A Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis
人类成年肌肉型烟碱受体在静息状态和脱敏状态下的结构 Li, A. PDF N/A Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states
使用脂质捕获质谱法识别分裂细胞中特定的脂质-蛋白质相互作用 Paquola, A. PDF N/A Identification of specific lipid-protein interactions in dividing cells using lipid-trap mass spectrometry
双编码基因SLC35A4具有抗氧化应激的保护作用。 Ajala, I. PDF N/A The dual coding gene SLC35A4 protects against oxidative stress
NOTCH1 S2513对于调控源自hiPSC的PSM细胞和体节体中NICD水平至关重要,影响着分节钟的运作。 Meijer, H. A. PDF N/A NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids
作为无害的乘客:寄生在埋葬甲虫Nicrophorus nepalensis身上的捕食性螨对择偶无影响 Lan, B. PDF N/A Phoretic mites as benign passengers: no influence on mate choice in the burying beetle Nicrophorus nepalensis
demres:一个用于研究时间变化人口复原力的R包 Louvrier, J. PDF N/A demres: An R package to study time-varying demographic resilience
两个不同的单倍体核塑造了小麦条锈病种群多样性的格局。 Wang, Y. PDF N/A Two divergent haploid nuclei shaped the landscape of population diversity in wheat stripe rust
gaftools:一个用于分析和操作泛基因组比对工具包 Pani, S. PDF N/A gaftools: a toolkit for analyzing and manipulating pangenome alignments
cancerSimCraft:一种具有全面基础真值追踪的多分辨率癌症基因组模拟器 Jin, H. PDF N/A cancerSimCraft: A Multi-resolution Cancer Genome Simulator with Comprehensive Ground Truth Tracking
整合转录组学、代谢组学和脂质组学分析揭示了调节性T细胞激活后的独特脂质特征 Sato, Y. PDF N/A Integrated transcriptomic, metabolomic, and lipidomic analyses reveal a unique lipid profile of regulatory T cells upon activation
一种从多潜能脑血管壁龛中分离血脑屏障和窗孔血管的分子机制 Lee, N. J. PDF N/A A molecular mechanism for blood-brain barrier and fenestrated vessel segregation from a multipotent cerebrovascular niche
雌二醇对大鼠认知衰老的益处与其对心血管代谢健康的影响无关。 Montanari, C. PDF N/A The benefits of estradiol on cognitive aging in rats are independent from its effects on cardiometabolic health
多反应性水凝胶纳米小瓶用于抗体分泌细胞分泌捕获的时间控制 Mellody, M. P. PDF N/A Multi-reactive hydrogel nanovials for temporal control of secretion capture from antibody-secreting cells
8纳米长的“意大利面”:从淡水中发现的,由冷冻技术揭示的,结构良好的糖类包裹的线性四肽重复序列。 Wang, T. PDF N/A The 8-nm spaghetti: well-structured glycans coating linear tetrapeptide repeats discovered from freshwater with CryoSeek
靶向KRAS(G12V)降解在体内有效且持久地诱导肺腺癌消退 Martin, A. PDF N/A Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo
使用OPM-MEG测量的听觉MMN的重测信度 Demko, L. PDF N/A Test-retest reliability of auditory MMN measured with OPM-MEG
在原始后生动物胚胎中,功能性神经回路的组装受到环境信号的影响,包括微生物群。 Noack, C. PDF N/A Assembly of a functional neuronal circuit in embryos of an ancestral metazoan is influenced by environmental signals including the microbiome
一个简单的神经回路模型解释了知觉决策中多种类型的整合核 Shen, X. PDF N/A A simple neural circuit model explains diverse types of integration kernels in perceptual decision-making
在疾病预测模型中使用抗体结构信息揭示了大量免疫组库数据中的抗原特异性B细胞受体序列 Nwogu, O. PDF N/A Use of Antibody Structural Information in Disease Prediction Models Reveals Antigen Specific B Cell Receptor Sequences in Bulk Repertoire Data
巨噬细胞迁移依赖的收缩纤维与迁移体——细胞因子时空分泌的结构基础。 Li, X. PDF N/A Macrophage migration-dependent retraction fibers and migrasomes - a structural basis for spatiotemporal cytokine secretion.
栖息地质量通过皮质醇影响西伯利亚鼯鼠(Pteromys volans)的肠道微生物群。 Petrullo, L. PDF N/A Habitat quality influences gut microbiota via cortisol in Siberian flying squirrels (Pteromys volans)
一个关于刀耕火种农业中劳动互惠和规范推理的复杂适应系统模型 Tverskoi, D. PDF N/A A complex adaptive systems model of labor reciprocity and normative reasoning in swidden agriculture
在鸟类(Vangidae)适应性辐射过程中,多个性状的进化速度和模式 Auerbach, A. L. B. PDF N/A Tempo and mode of evolution across multiple traits in an adaptive radiation of birds (Vangidae)
从ELOV2基因组区域评估DNA甲基化足以预测生理年龄。 Zhu, B. PDF N/A Assessment of DNA methylation from a single genomic region of ELOV2 is sufficient to predict chronological age
基因组分化塑造了芸苔属异源多倍体减数分裂同源重组的遗传调控 PELE, A. PDF N/A Genomic divergence shaped the genetic regulation of meiotic homologous recombination in Brassica allopolyploids
关于绒螯蟹属杂交与物种形成的基因组见解 Wang, C. PDF N/A Genomic Insights into Hybridization and Speciation of Mitten Crabs in the Eriocheir Genus
使用表面肌电图评估手动任务中的前臂用力:通过前臂与肌肉特定肌电图放置方式的比较分析 Fan, X. PDF N/A Assessing Forearm Exertion in Manual Tasks with Surface EMG: A Comparative Analysis of Through-Forearm vs. Muscle Specific EMG Placements
scSurv:一种用于单细胞生存分析的深度生成模型 Mizukoshi, C. PDF N/A scSurv: a deep generative model for single-cell survival analysis
环境盐度对鲑科鱼类独特神经内分泌复合体的调控 Culbert, B. M. PDF N/A Regulation of a unique neuroendocrine complex by environmental salinity in salmonid fishes
近亲繁殖和人口动态相互作用,影响种群从瓶颈效应中的恢复。 Zheng, J. PDF N/A Inbreeding and demography interact to impact population recovery from bottlenecks
能量转换预测冈比亚按蚊的死亡率 Zeferino, T. G. PDF N/A Energetic shifts predict the mortality of Anopheles gambiae