| 适应重金属污染环境的过程是通过对预先存在的遗传变异进行选择来进行的。 |
Wright, K. M. |
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N/A |
Adaptation to heavy-metal contaminated environments proceeds via selection on pre-existing genetic variation |
| CanSig：一种用于单细胞RNA-Seq数据中恶性状态发现基准测试的工具 |
Barkmann, F. |
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N/A |
CanSig: a tool for benchmarking malignant state discovery in single-cell RNA-Seq data |
| NMDA受体调控神经网络中的活动层次结构：层次结构控制失效导致学习障碍、分离现象和精神病 |
Zhou, Y. |
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N/A |
NMDA Receptors Control Activity Hierarchy in Neural Network: Loss of Control in Hierarchy Leads to Learning Impairments, Dissociation, and Psychosis |
| 植物基因组的高效组装：以毛茛属（毛茛科）为例探讨其进化意义 |
Karbstein, K. |
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N/A |
Efficient assembly of plant genomes: A case study with evolutionary implications in Ranunculus (Ranunculaceae) |
| 缺氧诱导因子在RSV感染期间对临床疾病和病毒复制控制的贡献存在差异。 |
Morris, D. R. |
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N/A |
Hypoxia-inducible-factors differentially contribute to clinical disease and the control of viral replication during RSV infection |
| 使用超分辨率超声定位显微镜对小鼠深部脑微血管进行纵向清醒成像 |
Wang, Y. |
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N/A |
Longitudinal Awake Imaging of Deep Mouse Brain Microvasculature with Super-resolution Ultrasound Localization Microscopy |
| 测序、对柳叶菜科植物叶绿体基因组进行从头组装，以及在柳叶菜科家族内的比较分析 |
Barloy-Hubler, F. |
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N/A |
Sequencing, de novo assembly of Ludwigia plastomes, and comparative analysis within the Onagraceae family |
| 多样性杂交小鼠中寿命可变性的分子结构 |
Hackett, S. R. |
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N/A |
The Molecular Architecture of Variable Lifespan in Diversity Outbred Mice |
| 建模低维交互脑网络揭示了人类认知的组织原则 |
Sanz Perl, Y. |
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N/A |
Modelling low-dimensional interacting brain networks reveals organising principle in human cognition |
| 压电依赖的基质硬度监测产生瞬时细胞，用于修复基底膜 |
Stricker, A. M. |
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N/A |
Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane |
| 肌萎缩侧索硬化症眶额皮层单核转录组图谱及基于深度学习的可变多聚腺苷酸化机制解码 |
McKeever, P. M. |
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N/A |
Single-nucleus transcriptome atlas of orbitofrontal cortex in amyotrophic lateral sclerosis with a deep learning-based decoding of alternative polyadenylation mechanisms |
| 通过获得自调控的超基因进化 |
VanKuren, N. W. |
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N/A |
Supergene evolution via gain of auto-regulation |
| ZNRF3/RNF43的丧失在癌症中释放了EGFR |
Yue, F. |
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N/A |
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer |
| 无靶向的代谢物比率对逐像素成像作为质谱成像中生物医学发现的新工具 |
Cheng, H. |
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N/A |
Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging |
| CELSR1在外部区域中由一个紧凑模块调控的结构基础 |
Bandekar, S. J. |
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N/A |
Structural basis for regulation of CELSR1 by a compact module in its extracellular region |
| β-连环蛋白通过与经典RNA结合蛋白结合，在髓系细胞中与Wnt信号mRNA网络相关联。 |
Wagstaff, M. |
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N/A |
β-Catenin associates with a Wnt signaling mRNA network in myeloid cells through canonical RBP binding. |
| 电休克对齿状回颗粒神经元的功能、回路和转录组的影响 |
Santiago, A. N. |
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N/A |
Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons |
| Vps5-Vps17 SNX-BAR蛋白与Retromer组装的分子基础 |
Chen, K.-E. |
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N/A |
Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer |
| 海马位置细胞的动态伽马调制在θ序列的发展中占主导地位 |
Wang, N. |
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N/A |
Dynamic Gamma Modulation of Hippocampal Place Cells Predominates Development of Theta Sequences |
| 发现RdRp Thumb-1作为一种新型广谱抗病毒靶标家族以及MDL-001作为一种强效广谱抑制剂 |
Woods, V. |
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N/A |
Discovery of RdRp Thumb-1 as a novel broad-spectrum antiviral family of targets and MDL-001 as a potent broad-spectrum inhibitor thereof |
| 早期视觉皮层中的主动干扰抑制 |
Richter, D. |
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N/A |
Proactive distractor suppression in early visual cortex |
| 对隐藏的注意力优先图进行Ping操作：抑制需要注意力 |
Huang, C. |
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N/A |
Pinging the Hidden Attentional Priority Map: Suppression Needs Attention |
| 染毒蛙蝌蚪中糖皮质激素应激反应的早期发育 |
Surber, L. L. |
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N/A |
Early development of the glucocorticoid stress response in dyeing poison frog tadpoles |
| 小鼠和非人灵长类动物发育中的大脑的功能成像 |
ZHU, J. |
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N/A |
Functional Imaging of Developing Brain in Mice and Non-Human Primates |
| RNA-TorsionBERT：利用语言模型进行RNA三维扭转角预测 |
Bernard, C. |
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N/A |
RNA-TorsionBERT: leveraging language models for RNA 3D torsion angles prediction |
| VIPER：一种用于预测酶底物的通用模型 |
Campbell, M. J. |
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N/A |
VIPER: A General Model for Prediction of Enzyme Substrates |
| Msp300（Nesprin）的一个独特同工型在脂肪细胞中组织了核周微管组织中心。 |
Morton, G. M. |
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N/A |
A distinct isoform of Msp300 (Nesprin) organizes the perinuclear microtubule organizing center in adipocytes |
| 无腔动物繁殖中的发育、再生和行为动态 |
Chandra, V. |
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N/A |
Developmental, regenerative, and behavioral dynamics in acoel reproduction |
| 使用深度学习方法建模伪对称溶质载体转运蛋白的替代构象状态 |
Swapna, G. V. T. |
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N/A |
Modeling Alternative Conformational States of Pseudo-Symmetric Solute Carrier Transporters using Methods from Deep Learning |
| 使用lr-kallisto进行长读长测序转录组定量 |
Loving, R. K. |
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N/A |
Long-read sequencing transcriptome quantification with lr-kallisto |
| 在酿酒酵母中，ATP合酶亚基复合体通过Novel If1机制防止ATP水解 |
Lerouley, O. |
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N/A |
Novel If1 mechanism preventing ATP hydrolysis by the ATP synthase subcomplex in Saccharomyces cerevisiae |
| 高阶（9阶）Ambisonics对声源定位的聚焦性及频谱重现误差对感知效果的影响 |
Zargarnezhad, N. |
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N/A |
Focality of sound source placement by higher (9th) order ambisonics and perceptual effects of spectral reproduction errors |
| 植物-真菌网络中信号传递与监测的演化 |
Scott, T. W. |
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N/A |
The evolution of signalling and monitoring in plant-fungal networks |
| 凝视反映了对明确决策的信心，同时依赖于一种独特的计算机制。 |
Stern, Y. |
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N/A |
Gaze reflects confidence in explicit decisions while relying on a distinct computational mechanism |
| 疼痛分布可以通过经典条件反射来确定。 |
Nastaj, J. |
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N/A |
Pain distribution can be determined by classical conditioning |
| 基因组组成可预测多倍体蝾螈对温度的生理反应 |
Burger, I. |
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N/A |
Genome composition predicts physiological responses to temperature in polyploid salamanders |
| 肌梭为运动序列提供灵活的感觉反馈。 |
Olson, W. P. |
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N/A |
Muscle spindles provide flexible sensory feedback for movement sequences |
| 肿瘤细胞的空间组织通过YAP信号传导引导EGFR/RAS/RAF通路对主要治疗产生抗性 |
Nakagawa, R. |
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N/A |
Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling |
| 一个针对环境16S rRNA牛津纳米孔测序数据进行改进分析的目标参考数据库 |
Philip, M. |
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N/A |
A Targeted Reference Database for Improved Analysis of Environmental 16S rRNA Oxford Nanopore Sequencing Data |
| 在“狗衰老项目”中，来自多样群体的狗的转座子DNA甲基化模式揭示了衰老差异。 |
Mariner, B. L. |
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N/A |
DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project |
| 细胞形状噪声强度调控EMT相关细胞扩展过程中形状变化的速度 |
Poenisch, W. |
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N/A |
Cell shape noise strength regulates the rate of shape change during EMT-associated cell spreading |
| 高表达的细胞壁基因有助于花萼大小的稳定性。 |
Hartasanchez, D. A. |
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N/A |
Highly expressed cell wall genes contribute to robustness of sepal size |
| P23H视紫红质在ER中的聚集导致视杆光感受器中突触蛋白失衡 |
Thompson, S. |
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N/A |
P23H rhodopsin aggregation in the ER causes synaptic protein imbalance in rod photoreceptors |
| 估计并纠正单细胞RNA-seq数据中的指数跳跃误分配 |
Miao, L. |
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N/A |
Estimating and correcting index hopping misassignments in single-cell RNA-seq data |
| 线粒体ETF不足通过选择性优化癌症生物能量代谢来驱动肿瘤生长。 |
Papadopoli, D. |
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N/A |
Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics |
| 在临床质子治疗系统的同步回旋加速器室内，对A549肺癌细胞和IMR90健康人体成纤维细胞进行体外FLASH照射。 |
Zazpe, A. |
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N/A |
In vitro FLASH irradiation of A549 lung cancer cells and IMR90 healthy human fibroblasts in the synchrocyclotron room of a clinical proton therapy system |
| 慢性感染SARS-CoV-2患者的宿主体内遗传多样性模式多样 |
Rutsinsky, N. |
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N/A |
Diverse patterns of intra-host genetic diversity in chronically infected SARS-CoV-2 patients |
| 重新评估爱泼斯坦-巴尔病毒（EBV）与美国乳腺癌之间的关联 |
Hu, C. C. |
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N/A |
Reevaluating the Association Between Epstein-Barr Virus (EBV) and Breast Cancer in the United States |
| 离开科学：38个经合组织国家生物学家的流失 |
Kwiek, M. |
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N/A |
Leaving Science: Attrition of Biologists in 38 OECD Countries |
| 不同的调控元件程序指导小鼠性腺发育过程中性别特异的支持细胞分化。 |
Stevant, I. |
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N/A |
Divergent regulatory element programs steer sex-specific supporting cell differentiation along mouse gonadal development |
| 用于晶体衍射数据质量评估的I/σI与{Rmerg, Rmeas, Rpim, CC1/2}关系图 |
Fu, Z. |
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N/A |
I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation |
| 一种用于分类学的时光机 |
Davis-Richardson, A. |
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N/A |
A Time Machine for Taxonomy |
| 鉴定髓样蛋白激酶C-ε为一个新型抗动脉粥样硬化基因 |
Wells, A. T. |
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N/A |
Identification of Myeloid Protein Kinase C - Epsilon as a Novel Atheroprotective Gene |
| 鉴定髓样蛋白激酶C-ε为一个新型抗动脉粥样硬化基因 |
Wells, A. T. |
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N/A |
Identification of Myeloid Protein Kinase C - Epsilon as a Novel Atheroprotective Gene |
| 结构上不同的锰感应核糖开关适配体调控多种表达平台架构 |
Stephen, C. |
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N/A |
Structurally distinct manganese-sensing riboswitch aptamers regulate diverse expression platform architectures |
| 十八烷类作为珊瑚-腰鞭虫共生中的新兴脂质介质 |
Botana, M. T. |
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N/A |
Octadecanoids as emerging lipid mediators in cnidarian-dinoflagellate symbiosis |
| 使用OPM-MEG测量的听觉MMN的重测信度 |
Demko, L. |
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N/A |
Test-retest reliability of auditory MMN measured with OPM-MEG |
| 栖息地质量通过皮质醇影响西伯利亚鼯鼠（Pteromys volans）的肠道微生物群 |
Petrullo, L. |
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N/A |
Habitat quality influences gut microbiota via cortisol in Siberian flying squirrels (Pteromys volans) |
| 通过NMDA受体GluN2B羧基末端域的非离子型信号传导驱动树突棘的形态可塑性，并逆转小鼠海马中的脆性X综合征表型 |
Barnes, S. A. |
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N/A |
Non-ionotropic signaling through the NMDA receptor GluN2B carboxy terminal domain drives morphological plasticity of dendritic spines and reverses fragile X phenotypes in mouse hippocampus |
| 早期生活逆境介导了基底节-杏仁核回路功能障碍，这种功能障碍是慢性疼痛和焦虑的基础。 |
Borruto, A. M. |
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N/A |
Early-life adversity mediates a thalamo-amgydalar circuit dysfunction underlying chronic pain and anxiety |
| PlexinA2、PlexinA4 和 NCAM 在发育中的海马苔藓纤维中具有多样化和位置特异性的作用 |
Zhao, X.-F. |
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N/A |
Diverse and Location-Specific Roles of PlexinA2, PlexinA4, and NCAM in Developing Hippocampal Mossy Fibers |
| 快速模拟血缘关系片段 |
Temple, S. D. |
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N/A |
Fast simulation of identity-by-descent segments |
| 一种简化的双质粒系统，用于使用光激活的CRISPR效应器对哺乳动物细胞进行正交基因表达控制 |
Garimella, S. S. |
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N/A |
A simplified two-plasmid system for orthogonal control of gene expression using light-activated CRISPR effector for mammalian cells |
| 黑色素瘤对免疫治疗的反应受B细胞衍生的细胞外囊泡调控 |
Al Hrout, A. |
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N/A |
Melanoma Response to Immunotherapy is regulated by B Cell-Derived Extracellular Vesicles |
| 眼球运动在人类海马中组织了兴奋性状态、信息编码和网络连接。 |
Leszczynski, M. |
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N/A |
Eye movements organize excitability state, information coding and network connectivity in the human hippocampus |
| 虚拟与现实世界模拟中的接近-回避偏差：来自实验设置系统性回顾的见解 |
Grasso-Cladera, A. |
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N/A |
Approach-Avoidance Bias in Virtual and Real-World Simulations: Insights from a Systematic Review of Experimental Setups |
| 从北到南：H1N1pdm09猪流感A病毒在意大利的传播动态 |
Giovanetti, M. |
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N/A |
From North to South: Transmission Dynamics of H1N1pdm09 Swine Influenza A Viruses in Italy |
| 特异性、长度和运气：罕见和常见变异关联研究如何优先考虑基因 |
Spence, J. P. |
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N/A |
Specificity, length, and luck: How genes are prioritized by rare and common variant association studies |
| 鉴定杜普伊特伦病的新的血浆蛋白质组学生物标志物 |
Hummer, B. |
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N/A |
Identification of novel plasma proteomic biomarkers of Dupuytren Disease |
| 构建多囊卵巢综合征中特定于颗粒细胞的ceRNA网络 |
Derevyanchuk, E. |
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N/A |
Construction of a ceRNA network specific for granulosa cells in PCOS |
| 人类组织中内含子保留数量性状位点的起源与意义 |
Park, E. |
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N/A |
Origins and Implications of Intron Retention Quantitative Trait Loci in Human Tissues |
| 巴西米纳斯吉拉斯州耳念珠菌的出现：基因组监测以指导快速公共卫生应对 |
Tome, L. M. R. |
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N/A |
Emergence of Candida auris in Minas Gerais, Brazil: Genomic Surveillance to inform Rapid Public Health Responses |
| 运动中的风险优化：从投掷中的运动和注视行为中获得的见解 |
Zahno, S. |
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N/A |
Risk optimization during ongoing movement: Insights from movement and gaze behavior in throwing |
| 慢性高强度间歇训练（HIIT）在青春期大鼠中进行的训练会导致可卡因条件性位置厌恶及ΔFosB的诱导。 |
Thanos, P. K. |
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N/A |
Chronic High Intensity Interval Training (HIIT) exercise in adolescent rat's result in cocaine place aversion and ΔFosB induction |
| 一个多尺度的电代谢大鼠新皮层电路模型揭示了衰老对中央皮层的影响 |
Farina, S. |
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N/A |
A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers |
| tRNASer3的双重解码展示了核糖体解码中心的可塑性。 |
Krishnaswamy, S. |
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N/A |
Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center |
| 实验性增温改变了湿润热带森林中的氮循环 |
Bartz, P. M. |
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N/A |
Experimental Warming Alters Nitrogen Cycle in a Humid Tropical Forest |
| 泥炭地恢复可以在所有时间尺度上提供气候变化缓解：一个英国案例研究 |
Zhang, X. |
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N/A |
Peatland restoration can provide climate change mitigation over all time-scales: A UK case-study |
| 不同果实特性沙棘品种的遗传多样性 |
Melnikova, N. V. |
PDF |
N/A |
Genetic Diversity of Hippophae rhamnoides Varieties with Different Fruit Characteristics |
| 受无序调控：磷酸化调节SRSF1域的可用性以促进剪接体成熟 |
Fargason, T. E. |
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N/A |
Controlled by disorder: phosphorylation modulates SRSF1 domain availability for spliceosome maturation |
| 探索在富含蓝藻的微生物群中同时生产聚羟基丁酸酯和胞外多糖 |
Gonzalez Flo, E. |
PDF |
N/A |
Exploring simultaneous production of polyhydroxybutyrate and exopolysaccharides in cyanobacteria-rich microbiomes |
| 使用图像引导光纤的结构光投影用于原位光生物制造 |
Chansoria, P. |
PDF |
N/A |
Structured light projection using image guide fibers for in situ photo-biofabrication |
| 用于密码子优化的预训练蛋白质语言模型 |
Pathak, S. |
PDF |
N/A |
Pre-trained protein language model for codon optimization |
| 评估Tropilaelaps mercedesae对多种合成杀螨剂的抗性水平。 |
Gill, M. C. |
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N/A |
Assessment of the levels of resistance of Tropilaelaps mercedesae to a variety of synthetic miticide. |
| 年轻和老年人在行走时对视觉干扰的内外平衡控制的敏感性 |
DiBianca, S. J. |
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N/A |
SENSITIVITY OF MEDIAL/LATERAL BALANCE CONTROL TO VISUAL DISTURBANCES WHILE WALKING IN YOUNG AND OLDER ADULTS |
| 电场方向对基于TMS的运动皮质映射的影响 |
Jing, Y. |
PDF |
N/A |
Effects of Electric Field Direction on TMS-based Motor Cortex Mapping |
| 衰老大脑中脉络丛体积减少的证据 |
Youh, R.-Y. |
PDF |
N/A |
Evidence for reduced choroid plexus volume in the aged brain |
| 基于数据非依赖采集（DIA）的无标记氧化还原蛋白质组学（DIALRP）揭示了新的氧化应激响应翻译因子 |
Kobayashi, D. |
PDF |
N/A |
Data-independent acquisition (DIA)-based Label-free Redox Proteomics (DIALRP) Reveals Novel Oxidative Stress Responsive Translation Factors |
| 基于数据非依赖采集（DIA）的无标记氧化还原蛋白质组学（DIALRP）揭示了新的氧化应激响应翻译因子 |
Kobayashi, D. |
PDF |
N/A |
Data-Independent Acquisition (DIA)-Based Label-Free Redox Proteomics (DIALRP) Reveals Novel Oxidative Stress Responsive Translation Factors |
| 非整倍体细胞的耗竭受到细胞间相互作用的影响。 |
Fusari, E. |
PDF |
N/A |
Depletion of aneuploid cells is shaped by cell-to-cell interactions |
| 在NLRP3炎症小体激活后，Gasdermin D介导了ATP的快速短暂释放，随后由ninjurin 1引发的溶细胞死亡。 |
Schachter, J. |
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N/A |
Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death |
| 鱼类精子上的守门人受体：探究精子与卵子的兼容性 |
Blaha, A. |
PDF |
N/A |
Bouncer's receptor on sperm: Investigating sperm-egg compatibility in fish |
| 使用贝叶斯推理量化CAR-T细胞对急性髓性白血病的性能 |
Shah, S. |
PDF |
N/A |
Quantification of CAR T cell performance against acute myeloid leukemia using Bayesian inference |
| 适应性塑造了小鼠视觉皮层（V1）中的表征几何结构，使其能够高效地编码环境信息。 |
Dipoppa, M. |
PDF |
N/A |
Adaptation shapes the representational geometry in mouse V1 to efficiently encode the environment |
| 密度依赖性阻碍了进化拯救。 |
Olazcuaga, L. |
PDF |
N/A |
Density dependence impedes evolutionary rescue |
| 生物入侵前沿的进化动力学 |
Poloni, S. |
PDF |
N/A |
Evolutionary dynamics at the leading edge ofbiological invasions |
| 通过配偶选择进行性选择何时会减少或夸大遗传变异：是否存在一个“求偶场悖论”？ |
Xu, K. |
PDF |
N/A |
When does sexual selection through mate choice deplete versus exaggerate genetic variation: is there a lek paradox? |
| 利用全基因组、线粒体DNA和单倍型区块来解析复杂的人口历史：以一种广泛混血的北极鱼类为例 |
Dallaire, X. |
PDF |
N/A |
Leveraging whole genomes, mitochondrial DNA, and haploblocks to decipher complex demographic histories: an example from a broadly admixed arctic fish |
| ΔNP63 定义了小鼠胰腺中一种向外分泌方向分化的多能祖细胞亚群。 |
Coolens, K. |
PDF |
N/A |
ΔNP63 defines an exocrine-committed multipotent progenitor subset in the murine pancreas |
| 在北海微藻水华期间，异养细菌对有机磺酸盐的利用中的资源划分 |
Sidhu, C. |
PDF |
N/A |
Resource partitioning in organosulfonate utilization by free-living heterotrophic bacteria during a North Sea microalgal bloom |
| 在年轻健康成年人中，观察协调的单腿站立起立动作并进行运动想象时，皮层脊髓兴奋性会增强。 |
Valapil, A. C. |
PDF |
N/A |
Corticospinal excitability is facilitated during coordinative action observation and motor imagery of adapted single-leg sit-to-stand movements in young healthy adults |
| 利用大型语言模型自动化候选基因优先排序：基于API驱动的工作流程的开发与基准测试，借助GPT-4技术 |
khan, T. |
PDF |
N/A |
Automating Candidate Gene Prioritization with Large Language Models: Development and Benchmarking of an API-Driven Workflow Leveraging GPT-4 |
| 亚胺培南/瑞来巴坦单独及联合使用对脓肿分枝杆菌囊性纤维化分离株的体外活性研究 |
Sanders, M. |
PDF |
N/A |
In Vitro Activity of Imipenem/Relebactam Alone and in Combination Against Cystic Fibrosis Isolates of Mycobacterium abscessus |
| 新生儿全身基因治疗在庞贝病大鼠模型中恢复了心肺功能 |
Fuller, D. |
PDF |
N/A |
Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease |
| 结合活体双光子成像与光激活荧光标记技术，揭示了骨骼肌中线粒体动力学的显著低速率。 |
O'Reilly, C. L. |
PDF |
N/A |
Combining in vivo 2-photon imaging with photoactivatable fluorescent labeling reveals strikingly low rates of mitochondrial dynamics in skeletal muscle. |
| MatriCom：一种用于推断ECM-ECM和细胞-ECM通信系统的scRNA-Seq数据挖掘工具 |
Lamba, R. |
PDF |
N/A |
MatriCom: a scRNA-Seq data mining tool to infer ECM-ECM and cell-ECM communication systems |
| μ-阿片受体激活增强了缰核-脚桥核突触的兴奋性传递。 |
Singhal, S. M. |
PDF |
N/A |
Mu-opioid receptor activation potentiates excitatory transmission at the habenulo-peduncular synapse |
| 经皮迷走神经刺激对噪音中语音识别的增强作用：一项交叉、安慰剂对照研究 |
Jigo, M. |
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N/A |
Cervical transcutaneous vagus nerve stimulation enhances speech recognition in noise: A crossover, placebo-controlled study |
| 体素级或区域级干扰回归在功能连接分析中的应用：有何区别？ |
Muganga, T. |
PDF |
N/A |
Voxel-wise or Region-wise Nuisance Regression for Functional Connectivity Analyses: Does it matter? |
| 由听觉剥夺引起的轴突起始段可塑性会降低对耳蜗植入神经反应模型中的时间差异敏感性。 |
Jing, A. |
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N/A |
Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants |
| 同时删除ZFP36L1和ZFP36L2基因可增强T细胞的细胞因子生成能力，但代价是细胞适应性下降。 |
Zandhuis, N. |
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N/A |
Combined deletion of ZFP36L1 and ZFP36L2 drives superior cytokine production in T cells at the cost of cell fitness |
| 一种新型的基于SARS-CoV-2衍生的传染性载体系统 |
Elfayres, G. |
PDF |
N/A |
A novel SARS-CoV-2-derived infectious vector system |
| 白斑综合症病毒早期蛋白（wsv100）通过拮抗NF-κB通路抑制虾的先天免疫反应 |
Xiao, B. |
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N/A |
White Spot Syndrome Virus Immediate-Early Protein (wsv100) Antagonizes the NF-kappaB Pathway to Inhibit Innate Immune Response in shrimp |
| 基于深度学习的病原性分枝杆菌化学积累预测 |
Sullivan, M. R. |
PDF |
N/A |
Deep learning-based prediction of chemical accumulation in a pathogenic mycobacterium |
| 将性二态性和左右不对称性整合到鸭鸣管的发育中 |
Mishkind, D. |
PDF |
N/A |
Integration of sexual dimorphism and left-right asymmetry in the development of the duck syrinx |
| Sox15是一种新发现的视网膜发育基因，通过抑制替代性视杆光感受器命运来促进视锥光感受器的分化。 |
Belair-Hickey, J. J. |
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N/A |
Sox15 is a novel retinal developmental gene that promotes cone photoreceptor differentiation through inhibition of alternative rod photoreceptor fates |
| 巴西坎皮纳斯市与洪水相关的钩端螺旋体病病例：排水系统、不透水区域与社会脆弱性之间的相互作用 |
de Azevedo, T. S. |
PDF |
N/A |
Flood-related cases of leptospirosis in Campinas, Brazil: the interplay between drainage, impermeable areas and social vulnerability |
| 一种用于全球物种分布预测的生成式深度学习方法 |
YAN, Y. |
PDF |
N/A |
A generative deep learning approach for global species distribution prediction |
| 稻瘟病菌株中高度动态的额外小染色体 |
Lin, G. |
PDF |
N/A |
Highly dynamic supernumerary mini-chromosomes in a Magnaporthe oryzae strain |
| 利用机器学习提高对肺炎克雷伯菌抗菌药物耐药性的预测 |
Sevilla, J. |
PDF |
N/A |
Improved prediction of antimicrobial resistance in Klebsiella pneumoniae using machine learning |
| 姜黄精油局部应用可减轻丙酮诱导的Wistar白化大鼠特应性皮炎中的炎症标志物。 |
Musyoka, A. M. |
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N/A |
Curcuma longa Essential Oil Topically Mitigates Inflammatory Markers in Acetone-Induced Atopic Dermatitis in Wistar Albino Rats |
| 骨靶向肽选择用于治疗干预：体内评估与比较研究 |
Stellpflug, A. |
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N/A |
Selection of Bone-Targeting Peptides for Therapeutic Intervention: An In Vivo Evaluation and Comparison Study |
| ConvMut：一种用于分析病毒系统发育中趋同突变的网络工具 |
Bernasconi, A. |
PDF |
N/A |
ConvMut: A Web tool to analyze viral convergent mutations along phylogenies |
| 用于对药物发现平台进行稳健、准确和可推广基准测试的策略 |
Van Norden, M. |
PDF |
N/A |
Strategies for robust, accurate, and generalizable benchmarking of drug discovery platforms |
| 患有长期新冠病毒的仓鼠在大脑干中表现出神经退行性特征。 |
Coleon, A. |
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N/A |
Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem |
| 在ADAMTS13缺乏的情况下，微血栓的形成通过黏膜和内皮功能障碍加剧了溃疡性结肠炎。 |
Tatsuta, K. |
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N/A |
Microthrombi-growth in ADAMTS13 deficiency exacerbated ulcerative colitis via mucosal and endothelial dysfunction |
| 在肠道环境中，合成益生菌中用于消除目标基因的遗传安全措施 |
Nguyen, N. |
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N/A |
A genetic safeguard for eliminating target genes in synthetic probiotics in a gut environment |
| 酶CAGE：一种基于几何的酶检索基础模型，具有进化洞察力 |
Liu, Y. |
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N/A |
EnzymeCAGE: A Geometric Foundation Model for Enzyme Retrieval with Evolutionary Insights |
| 利用声遗传学-fPET技术，对基因和空间上有针对性地选择的神经群体进行无创调节，并映射其全球因果反应 |
Yang, Y. |
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N/A |
Mapping Global Causal Responses to Noninvasive Modulation of Genetically and Spatially Targeted Neural Populations with Sonogenetic-fPET |
| 有意延长与自发延长注视：基于主动注视交互的MEG研究 |
Vasilyev, A. N. |
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N/A |
Intentionally vs. Spontaneously Prolonged Gaze: A MEG Study of Active Gaze-Based Interaction |
| NK细胞控制骨髓增生异常综合征的进展，但在NUP98-HOXD13小鼠模型中成为初始疾病靶点。 |
Telliam Dushime, G. |
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N/A |
NK cells control the progression of myelodysplastic syndrome but become initial disease target in NUP98-HOXD13 mouse model |
| NLRP11在人巨噬细胞感染分枝杆菌期间，对于经典NLRP3和非经典炎症小体的激活是必需的。 |
Szczerba, M. |
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N/A |
NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria |
| 一种bactofilin的亚域功能特化在Asticcacaulis biprosthecum中驱动柄状结构形态发生 |
Jacq, M. |
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N/A |
Functional specialization of the subdomains of a bactofilin driving stalk morphogenesis in Asticcacaulis biprosthecum |
| 对番茄潜叶蛾病毒组的特征分析揭示了田间种群中更高的病毒多样性 |
Becerra-Garcia, R. E. |
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N/A |
Characterization of the Tuta absoluta virome reveals higher viral diversity in field populations |
| 泛北极地区完整和退化多年冻土中的甲烷循环微生物群落 |
Wang, H. |
PDF |
N/A |
The methane-cycling microbiome in intact and degraded permafrost soils of the pan-Arctic |
| 多组学视角下黄曲霉对长链烷烃响应与聚乙烯降解的关系研究 |
Siaperas, R. |
PDF |
N/A |
Multi-omics insights into the response of Aspergillus parasiticus to long-chain alkanes in relation to polyethylene degradation |
| Tax1bp1增强细菌的毒力，并在结核分枝杆菌感染肺泡巨噬细胞期间促进炎症反应。 |
Chin, J. |
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N/A |
Tax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages |
| Tunicate（被囊动物）的元转录组揭示了在致病病毒的进化历史中，古老的病毒-宿主共同分化以及目间重组的现象。 |
Petrone, M. E. |
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N/A |
Tunicate metatranscriptomes reveal ancient virus-host co-divergence and inter-order recombination in the evolutionary history of disease-causing viruses |
| 噬菌体Kil肽折叠成预测的螺旋-转角-螺旋结构，以破坏大肠杆菌细胞分裂。 |
Naha, A. |
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N/A |
Bacteriophage Kil peptide folds into a predicted helix-turn-helix structure to disrupt Escherichia coli cell division |
| 一种通过细胞外囊泡监测蛋白质转移的新方法 |
Pigden, O. |
PDF |
N/A |
A New Approach to Monitoring Protein Transfer via Extracellular Vesicles |
| SARS-CoV-2中高度重复的多核苷酸突变 |
De Maio, N. |
PDF |
N/A |
Highly recurrent multi-nucleotide mutations in SARS-CoV-2 |
| 从多种人类细胞类型中高效的无细胞翻译 |
Ziegelmueller, J. |
PDF |
N/A |
Efficient cell-free translation from diverse human cell types |
| USP1/UAF1通过一种外切酶切机制，特异性地识别并作用于多聚泛素化的PCNA，从而富集单泛素化的PCNA。 |
Keijzer, N. |
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N/A |
USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that enriches for monoubiquitinated PCNA |
| 使用GATE模拟前列腺癌患者来源的骨转移活检中的微米级阿尔法粒子剂量 |
Said, A. |
PDF |
N/A |
Simulating Alpha Particle Doses at the Micron Scale from Prostate Cancer Patient Derived Bone Metastatic Biopsies Using GATE |
| 基于人工智能的模型用于预测游离DNA样本中的克隆性造血突变 |
Arango-Argoty, G. |
PDF |
N/A |
An artificial intelligence-based model for prediction of Clonal Hematopoiesis mutants in cell-free DNA samples |
| 在白血病机器学习分类中使用保形预测减少错误 |
Lysenkova Wiklander, M. |
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N/A |
Error reduction in leukemia machine learning classification with conformal prediction |
| 使用抗HVEM阻断单克隆抗体治疗多种实体癌的新型免疫疗法 |
Galore-Haskel, G. |
PDF |
N/A |
Novel immunotherapy for multiple solid cancers using an Anti-HVEM blocking monoclonal antibody |
| PARP抑制剂逆转了胶质母细胞瘤多形性对替莫唑胺的耐药性。 |
Samarut, E. |
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N/A |
PARP inhibitor counteracts Temozolomide Resistance in Glioblastoma Multiforme |
| 多重镶嵌肿瘤模型揭示了在群体内和群体间的药物反应中自然表型变异 |
Yu, J. X. |
PDF |
N/A |
Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations |
| 莱茵衣藻CLiP2突变体库通过高置信度的破坏性等位基因扩展了基因组覆盖范围。 |
Lunardon, A. |
PDF |
N/A |
The Chlamydomonas reinhardtii CLiP2 mutant collection expands genome coverage with high-confidence disrupting alleles |
| 细菌中用于RNA感应的条件性Degron标签 |
Simons, T. J. |
PDF |
N/A |
A Conditional Degron Tag for RNA Sensing in Bacteria |
| 为设计新型结合剂，绘制人类表面组上的可靶向位点 |
Balbi, P. E. M. |
PDF |
N/A |
Mapping targetable sites on the human surfaceome for the design of novel binders |
| 研究机械适应对空中超声振动触觉刺激的影响 |
Cataldo, A. |
PDF |
N/A |
Investigating the effect of mechanical adaptation on mid-air ultrasound vibrotactile stimuli |
| 氟西汀的青春期治疗会影响雌性青春期大鼠内侧前额叶皮层的成熟和行为 |
Kryst, J. |
PDF |
N/A |
Juvenile fluoxetine treatment affects the maturation of the medial prefrontal cortex and behavior of adolescent female rats |
| 有意义的记忆的随机树模型 |
Zhong, W. |
PDF |
N/A |
Random Tree Model of Meaningful Memory |
| 通过tRNS调节前刺激的阿尔法和贝塔节律功率，确立了它们在视觉感知中的因果作用。 |
Wei, J. |
PDF |
N/A |
Modulating Prestimulus Alpha and Beta Power with tRNS Establishes Their Causal Role in Visual Perception |
| 后内侧皮质中自然事件记忆再激活的核心神经状态集 |
Lee, Y. |
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N/A |
A core set of neural states underlying memory reactivation of naturalistic events in the posterior medial cortex |
| T型钙通道参与了脊髓背角PKCγ神经元在慢性疼痛期间的内在和突触活动。 |
Cuculiere, C. |
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N/A |
T-type calcium channels participate in intrinsic and synaptic activity of PKCγ neurons of the dorsal horn of the spinal cord during chronic pain |
| 巨细胞病毒和类风湿性关节炎对衰老的CD4+ T细胞具有不同的影响 |
Williams, L. |
PDF |
N/A |
Divergent effects of cytomegalovirus and rheumatoid arthritis on senescent CD4+ T cells |
| 在乌苏图病毒脑炎期间，CCR2在单核细胞招募和血脑屏障破坏中起着核心作用。 |
Slowikowski, E. |
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N/A |
A central role for CCR2 in monocyte recruitment and blood-brain barrier disruption during Usutu virus encephalitis |
| 尽管糖基转移酶表达相同，IgA在位点和亚类上仍表现出特定的糖型差异。 |
Falck, D. |
PDF |
N/A |
IgA displays site- and subclass-specific glycoform differences despite equal glycoenzyme expression |
| 海藻糖二霉菌酸酯通过非经典SNARE相互作用抑制吞噬体成熟并促进胞内结核分枝杆菌生长。 |
Santamaria, C. |
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N/A |
Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonical SNARE interaction |
| 使用ARTiMiS流式成像显微技术对营养回收过程中微藻群落的形态型进行解析 |
Gincley, B. |
PDF |
N/A |
Morphotype-Resolved Characterization of Microalgal Communities in a Nutrient Recovery Process with ARTiMiS Flow Imaging Microscopy |
| 2016年至2022年荷兰乌苏图病毒和西尼罗病毒的出现与动态 |
Munger, E. |
PDF |
N/A |
Emergence and Dynamics of Usutu and West Nile Viruses in the Netherlands, 2016-2022 |
| DIYNAFLUOR：一种经济实惠的即插即用型核酸荧光计，适用于资源有限环境中的环境DNA定量分析 |
Anderson, W. |
PDF |
N/A |
DIYNAFLUOR: An Affordable DIY Plug-and-Play Nucleic Acid Fluorometer for eDNA Quantification in Resource Limited Settings |
| 人类RNase H2的上调能够对抗癌基因和化疗引起的复制压力。 |
Wilkins, R. J. |
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N/A |
Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress |
| 细胞连接mRNA的本地化翻译对于上皮细胞极性是必需的。 |
Chin, A. |
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N/A |
Localized translation of cell junction mRNAs is required for epithelial cell polarity |
| Maf1与孕酮受体合作，共同抑制RNA聚合酶III对特定tRNA的转录。 |
Finlay-Schultz, J. |
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N/A |
Maf1 Cooperates with Progesterone Receptor to Repress RNA Polymerase III Transcription of Select tRNAs |
| 入侵的仙人掌（Opuntia cacti）对哺乳动物栖息地使用的影响对比 |
Stewart, P. S. |
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N/A |
Contrasting impacts of invasive Opuntia cacti on mammal habitat use |
| 田野蟋蟀中武器和攻击行为的进化 |
Judge, K. A. |
PDF |
N/A |
The evolution of weaponry and aggressive behaviour in field crickets |
| 生态资源竞争作为金属组进化的一种驱动力 |
Sobol, M. |
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N/A |
Ecological resource competition as a driver of metallome evolution |
| 超越大陆群体的人类遗传变异的多尺度复杂性 |
Palma-Martinez, M. J. |
PDF |
N/A |
The multi-scale complexity of human genetic variation beyond continental groups |
| 通过衰老在果蝇头部基因表达的动态变化 |
Macdonald, S. J. |
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N/A |
Dynamic Changes in Gene Expression Through Aging in Drosophila melanogaster Heads |
| 传感器融合算法用于提高使用六自由度位置传感器进行机器人叠加测试的精度 |
Gillespie, C. M. |
PDF |
N/A |
Sensor Fusion Algorithm to Improve Accuracy of Robotic Superposition Testing using 6-DOF Position Sensors |
| FeatureForest：结合基础模型的强大功能与随机森林的易用性 |
Seifi, M. |
PDF |
N/A |
FeatureForest: the power of foundation models, theusability of random forests |
| 机器学习预测超越单个mRNA作为单细胞蛋白质表达的代理 |
Fisher, J. |
PDF |
N/A |
Machine Learning Predictions Surpass Individual mRNAs as a Proxy of Single-cell Protein Expression |
| Prosit-XL：通过精确的片段强度预测增强交联肽鉴定，用于研究蛋白质-蛋白质相互作用和蛋白质结构 |
Kalhor, M. |
PDF |
N/A |
Prosit-XL: enhanced cross-linked peptide identification by accurate fragment intensity prediction to study protein-protein interactions and protein structures |
| 一个专注于精准肿瘤学的深度学习框架，用于个性化选择癌症治疗方案 |
Sederman, C. |
PDF |
N/A |
A precision oncology-focused deep learning framework for personalized selection of cancer therapy |
| SL/Kh 前B细胞淋巴瘤起源于胸腺，是原发性纵隔（胸腺）大B细胞淋巴瘤的一个模型。 |
Thomae, T. L. |
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N/A |
SL/Kh Pre-B Lymphomas Originate in the Thymus and are a Model for Primary Mediastinal (Thymic) Large B-Cell Lymphoma |
| 敲入Kcnh2的长QT综合征2型、癫痫和猝死兔模型 |
Singh, V. |
PDF |
N/A |
Knock-in Kcnh2 Rabbit Model of Long QT Syndrome Type-2, Epilepsy, and Sudden Death |
| 通过基因沉默KCa3.1可抑制ApoE基因敲除小鼠的动脉粥样硬化。 |
Alam, P. |
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N/A |
Genetic silencing of KCa3.1 inhibits atherosclerosis in ApoE null mice |
| 高产环境下油菜籽灌浆期耐热性的研究 |
Verdejo, J. F. |
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N/A |
Resilience of rapeseed to heat stress during grain filling in a high yielding environment |
| 基因组尺度模型中噬菌体代谢劫持的协同与拮抗作用 |
Rozum, J. C. |
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N/A |
Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophage |
| 在奖励最大化过程中位置场重组的模型 |
Kumar, M. G. |
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N/A |
A Model of Place Field Reorganization During Reward Maximization |
| 皮层状态变化通过听觉异常：无意识中的失配反应生成机制 |
Hockley, A. |
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Cortical state change by auditory deviants: a mismatch response generation mechanism in unconsciousness |
| 惩罚性时间判断增强了代理感，并调节了其潜在的神经相关因素。 |
Hill, C. |
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Punishing temporal judgement boosts sense of agency and modulates its underlying neural correlates |
| 前额叶皮层多巴胺对刺激的总效价产生反应。 |
Yang, Y. |
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Prefrontal cortex dopamine responds to the total valence of stimuli |
| 蛋白质组传感器用于定量、多重和空间监测激酶信号传导 |
Comstock, W. J. |
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Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling |
| 鉴定出对逆转录转座必需的最小Alu域 |
Moldovan, J. B. |
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Identification of a minimal Alu domain required for retrotransposition |
| 利用培养边界条件调控肾脏发育轨迹 |
Huang, A. Z. |
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Engineering kidney developmental trajectory using culture boundary conditions |
| 羽毛图标：鸟类物种吸引全球关注的驱动力 |
Si, H. |
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Feathered Icons: Drivers of Global Attention on Bird Species |
| 未来的气候和土地利用变化将同样影响全球陆地脊椎动物的多样性。 |
Hari, C. |
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Future climate and land use change will equally impact global terrestrial vertebrate diversity |
| 发送混合信号：亚马逊蝴蝶同域姐妹物种中的趋同虹彩和趋异化学信号 |
Ledamoisel, J. |
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Sending mixed signals: convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies |
| 递归剪接去除内含子是否是基因组巨型化演化的必要条件？ |
Adams, A. N. |
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Is intron removal by recursive splicing necessitated by the evolution of genomic gigantism? |
| 具有性二态尾羽的燕子具有更高的物种形成速率。 |
Hasegawa, M. |
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Swallows with sexually dimorphic tails have higher speciation rates |
| 结构重排和选择促进安乐蜥蜴的表型进化 |
Araya Donoso, R. |
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Structural rearrangements and selection promote phenotypic evolution in Anolis lizards |
| 从单核ATAC-seq获得的高分辨率减数分裂交叉图揭示了哺乳动物精子中重组景观的见解 |
Crismani, W. |
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A high-resolution meiotic crossover map from single-nucleus ATAC-seq reveals insights into the recombination landscape in mammalian sperm |
| 组织特异性表观线粒体DNA异质性及其与衰老和线粒体DNA基因表达的关系 |
Wengert, S. |
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Tissue-specific apparent mtDNA heteroplasmy and its relationship with ageing and mtDNA gene expression |
| 携带超大负荷可能会在切叶蚁中产生信息素“盲点”。 |
Porras-Brenes, K. |
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Carrying oversized loads may create pheromone 'blind spots' in leafcutter ants. |
| 利用四向相位编码优势实现EPI伪影的鲁棒检测与校正：应用于扩散MRI中的残余鬼影 |
Thai, A. |
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Exploiting Four-way Phase-encoding Benefits for Robust Detection and Correction of EPI artifacts: Application to Residual Ghosts in Diffusion MRI. |
| 以人工智能为核心的致病蛋白质靶点结构识别 |
Saluri, M. |
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AI-first structural identification of pathogenic protein targets |
| 基于领域自适应蛋白质语言模型和可解释几何深度学习的精确核酸结合残基识别 |
Zeng, W. |
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Accurate nucleic acid-binding residue identification based on domain-adaptive protein language model and explainable geometric deep learning |
| 食物质量和vgll3基因型影响大西洋雌性鲑鱼的繁殖特征。 |
Maamela, K. S. |
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Food quality and vgll3 genotype influence reproductive traits in female Atlantic salmon |
| 微生物功能群和基因是解释土壤养分循环的关键，与土壤和植物变量同样重要。 |
Vietorisz, C. R. |
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Microbial functional guilds and genes are key to explaining soil nutrient cycling alongside soil and plant variables |
| 恢复阿尔茨海默病中的振荡动力学：一种关于血清素类迷幻药物作用的分层全脑模型 |
Gendra, J. C. |
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Restoring Oscillatory Dynamics in Alzheimer's Disease: A Laminar Whole-Brain Model of Serotonergic Psychedelic Effects |
| Foxg1及其伙伴们：不仅仅是转录因子 |
Mallamaci, A. |
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Foxg1 and companions: not only transcription factors |
| 邻里剥夺、遗传易感性与生活满意度：来自德国双生子家庭面板的证据 |
Harerimana, N. V. |
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Neighborhood Deprivation, Genetic Predisposition, and Life Satisfaction: Evidence from the German Twin Family Panel |