| sortase组装的Ebp菌毛在粪肠球菌粘附于氧化铁及其对胞外电子传递影响中的作用 |
Ho, F. K. |
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N/A |
Role of sortase-assembled Ebp pili in Enterococcus faecalis adhesion to iron oxides and its impact on extracellular electron transfer |
| 突变和选择对秀丽隐杆线虫对细菌病原体易感性的累积效应 |
Saber, S. |
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N/A |
Cumulative effects of mutation and selection on susceptibility to bacterial pathogens in Caenorhabditis elegans |
| 光感受器与视网膜色素上皮之间的葡萄糖和乳酸的体内交换 |
Hass, D. T. |
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N/A |
In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium |
| 环境DNA在评估再生农业下蚯蚓生物多样性恢复方面比手工分类更为有效。 |
Llanos, J. |
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N/A |
Environmental DNA is more effective than hand sorting in evaluating earthworm biodiversity recovery under regenerative agriculture |
| 扩展深度可识别模型能够实现单细胞生物状态的零样本表征 |
Dong, M. |
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N/A |
Scaling deep identifiable models enables zero-shot characterization of single-cell biological states |
| 选择预期作为感官预测的门控累积 |
Caie, B. |
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N/A |
Choice anticipation as gated accumulation of sensory predictions |
| 通过寄生而非捕食频繁传播的沃尔巴克氏菌的种间传播 |
Yan, Z.-C. |
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N/A |
Frequent intertrophic transmission of Wolbachia by parasitism but not predation |
| 简单的壳体测量并不能始终准确预测龟类的栖息地：对Lichtig和Lucas（2017）的回应 |
Evers, S. W. |
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N/A |
Simple shell measurements do not consistently predict habitat in turtles: a reply to Lichtig and Lucas (2017) |
| 一种应激依赖的TDP-43 SUMO化程序维持神经元功能 |
Suk, T. R. |
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N/A |
A stress-dependent TDP-43 SUMOylation program preserves neuronal function |
| 循环肿瘤细胞在毛细血管大小的分叉处释放大量细胞外囊泡。 |
Vrynas, A. |
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N/A |
Circulating tumor cells shed large extracellular vesicles in capillary-sized bifurcations |
| 皮层对层次化节奏的追踪，协调了生物运动的多感官处理过程。 |
Shen, L. |
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N/A |
Cortical tracking of hierarchical rhythms orchestrates the multisensory processing of biological motion |
| MDF调控了拟南芥中依赖和不依赖生长素的侧根再生途径网络。 |
Aldowigh, F. |
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N/A |
MDF regulates a network of auxin-dependent and -independent pathways of adventitious root regeneration in Arabidopsis. |
| 一种宿主酶通过灭活肠道脂多糖来减轻代谢功能障碍相关脂肪性肝病（MASLD） |
Wang, Z. |
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N/A |
A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide |
| 从无人机记录的蝴蝶运动描绘了其在野外的迁徙飞行行为。 |
de Margerie, E. |
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N/A |
Butterfly movements recorded from a UAV depict migratory flight behaviour in the wild. |
| 一种新方法（RIM-Deep）增强了倒置共聚焦显微镜下深层清除脑组织成像的深度和分辨率稳定性。 |
Liu, Y. |
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N/A |
A novel method (RIM-Deep) enhances imaging depth and resolution stability of deep-cleared brain tissue in inverted confocal microscopy |
| 监控与群体网络协同作用在理解2018年法国大都会区乌苏病毒在普通乌鸫（Turdus merula）中的爆发中的相关性 |
Bouchez-Zacria, M. |
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N/A |
Relevance of the synergy of surveillance and populational networks in understanding the Usutu virus outbreak within common blackbirds (Turdus merula) in Metropolitan France, 2018 |
| PA28γ通过提高线粒体功能促进肿瘤的恶性进展，这一过程依赖于C1QBP。 |
Wang, J. |
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N/A |
PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP |
| 细胞类型间代谢身份的表观遗传调控 |
Pacheco, M. P. |
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N/A |
Epigenetic control of metabolic identity across cell types |
| 突出发病机制的复杂性：宿主微生物群影响苹果果实疾病的发展，是其生物防治的基石。 |
Sare, A. R. |
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N/A |
Highlighting the complexity of pathogenesis: the host microbiota impacts disease development on apple fruit and is a cornerstone for its biocontrol |
| 利用angioMASH组织清除和标记技术，在三维空间中研究人类视觉皮层的微观血管结构。 |
Hildebrand, S. |
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N/A |
Investigating microscopic angioarchitecture in the human visual cortex in 3D with angioMASH tissue clearing and labelling |
| 澳大利亚犬钩虫（Ancylostoma caninum）中普遍存在苯并咪唑抗性单核苷酸多态性 |
Abdullah, S. |
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N/A |
Widespread occurrence of benzimidazole resistance single nucleotide polymorphisms in the canine hookworm, Ancylostoma caninum, in Australia |
| ERK2二聚体在突触可塑性和记忆中的作用 |
Ojea Ramos, S. |
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N/A |
Role of ERK2 dimerization in synaptic plasticity and memory |
| 神经元培养基中星形胶质细胞Nrf2的基础激活：神经元-星形胶质细胞模型构建的挑战与意义 |
Elsharkasi, M. M. O. |
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N/A |
Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling |
| 鉴定新型毒素结构域并表征广泛分布的脂质靶向NlpC/P60家族。 |
Nicastro, G. G. |
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N/A |
Identification of novel toxin domains and characterization of a broadly distributed family of lipid-targeting NlpC/P60. |
| 使用12-6 Lennard-Jones势能模型模拟银(I)离子与蛋白质的相互作用：一种自下而上的参数化方法 |
Manciocchi, L. |
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N/A |
Modelling the interaction between silver(I) ion and proteins with the 12-6 Lennard-Jones potential: a bottom-up parameterization approach |
| 鸟类端脑和小脑的体积可以通过数字脑内模精确估算。 |
Keirnan, A. R. |
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N/A |
Avian telencephalon and cerebellum volumes can be accurately estimated from digital brain endocasts |
| 蛋白质进化中的波动与可预测性极限 |
Rossi, S. |
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N/A |
Fluctuations and the limit of predictability in protein evolution |
| PARP抑制剂可逆转替莫唑胺在多形性胶质母细胞瘤中的耐药性。 |
Samarut, E. |
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N/A |
PARP inhibitor counteracts Temozolomide Resistance in Glioblastoma Multiforme |
| 利用组织病理学图像进行个性化医疗的深度学习驱动结直肠癌亚型分类 |
Trong Le Phan, N. |
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N/A |
Deep Learning-Driven Subtype Classification of Colorectal Cancer Using Histopathology Images for Personalized Medicine |
| 自然语言理解在理解后的一秒内会激活一系列广泛的大脑网络。 |
Hong, M. K. |
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N/A |
Naturalistic language comprehension engages a cascade of widespread brain networks in the one second following comprehension |
| 通过对数百个不同大脑进行长读段测序，我们得以深入了解结构变异对基因表达和DNA甲基化的影响。 |
Billingsley, K. J. |
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N/A |
Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation |
| 卡西尼：用于RNA和蛋白质原位分析的流线型可扩展方法 |
Lapique, N. |
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N/A |
Cassini: Streamlined and Scalable Method for in situ profiling of RNA and Protein |
| 非洲疟疾媒介按蚊的基因组多样性 |
Bodde, M. |
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N/A |
Genomic diversity of the African malaria vector Anopheles funestus |
| 发育中的人脑的三维组织学细胞图谱 |
Jayakumar, J. |
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N/A |
A three-dimensional histological cell atlas of the developing human brain |
| 整合宏基因组组装的基因组与临床分离株揭示了克雷伯氏肺炎菌在携带和疾病中的基因组特征 |
Gupta, S. |
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N/A |
Integration of metagenome-assembled genomes with clinical isolates reveals genomic signatures of Klebsiella pneumoniae in carriage and disease |
| 盐诱导的蜡样芽孢杆菌MHS的超蠕动运动减少与鞭毛减少、纳米管形成减少以及群体感应调节因子表达减少有关。 |
Bhadani, N. K. |
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N/A |
Salt-induced reduction of hyperswarming motility in Bacillus cereus MHS is associated with reduced flagellation, reduced nanotube formation and reduction in expression of quorum sensing regulator |
| 评估多粘菌素B与三氯生联合治疗对耐粘菌素肺炎克雷伯菌的疗效 |
Biswas, S. |
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N/A |
Assessing the efficacy of therapeutically promising combination of polymyxin B and triclosan against colistin resistant Klebsiella pneumoniae |
| 己糖胺生物合成中断会损害GPI生产并使恶性疟原虫在裂殖体阶段停止生长 |
Alberione, M. P. |
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N/A |
Hexosamine Biosynthesis Disruption Impairs GPI Production and Arrests Plasmodium falciparum Growth at Schizont Stages |
| 异氟芬喹，新型二氢乳清酸脱氢酶抑制剂：对草莓病害的疗效及通过AlphaFold2和Autodock Vina进行的对接模拟 |
Choi, S. |
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N/A |
Ipflufenoquin, Novel Dihydroorotate Dehydrogenase Inhibitor: Efficacy Against Strawberry Diseases and Docking Simulations via AlphaFold2 and Autodock Vina |
| 与RNA聚合酶II和RNA相互作用的保守蛋白Seb1是一种真正的转录延伸因子。 |
Kus, K. |
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N/A |
Conserved protein Seb1 that interacts with RNA polymerase II and RNA is a bona fide transcription elongation factor |
| 通过隐秘口袋映射与X射线片段筛选相结合，增强了对与hnRNPA1结合的小分子的识别。 |
Dunnett, L. |
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N/A |
Enhanced identification of small molecules binding to hnRNPA1 via cryptic pockets mapping coupled with X-Ray fragment screening |
| 在工程菌中结合生物合成与位点特异性引入苯丙氨酸衍生物：从芳香醛或羧酸合成 |
Anderson, S. |
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N/A |
Combined biosynthesis and site-specific incorporation of phenylalanine derivatives from aryl aldehydes or carboxylic acids in engineered bacteria |
| 一种在大肠杆菌中生产生物活性肽的蛋白质笼系统 |
Harding, M. D. |
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N/A |
A protein cage system for producing bioactive peptides in Escherichia coli |
| 网格蛋白参与了疟原虫对宿主细胞质内吞作用的过程。 |
Miao, J. |
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N/A |
Clathrins are involved in the endocytosis of host cytosol in the malaria parasite |
| 将解构的酸面团群落和发酵参数应用于低FODMAP小麦面包的生产。 |
Wittwer, A. E. |
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N/A |
Applying deconstructed sourdough communities and fermentation parameters to low-FODMAP wheat bread production |
| 氧化应激激发吡嗪酰胺对结核分枝杆菌的强效杀菌活性 |
Dillon, N. |
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N/A |
Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis |
| 金黄色葡萄球菌滑行彗星：形成与观察 |
Pollitt, E. |
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N/A |
Staphylococcus aureus gliding comets: formation and observation |
| 一项针对沙门氏菌肠亚种鼠伤寒沙门氏菌的全基因组CRISPRi筛选揭示了I型菌毛在逃避抗体介导的凝集中的作用。 |
Lindberg, S. K. |
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N/A |
A Salmonella enterica serovar Typhimurium Genome-wide CRISPRi Screen Reveals a Role for Type 1 Fimbriae in Evasion of Antibody-Mediated Agglutination |
| 微生物对海藻酸盐的觅食行为在地理和分类学上不同的反刍动物微生物群中是保守的。 |
Ferrillo, A. |
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N/A |
Microbial alginate foraging is conserved in geographically and taxonomically distinct ruminant microbiomes |
| 在变异链球菌菌株中检测防御系统和前噬菌体 |
Claisse, O. |
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N/A |
Defense systems and prophage detection in Streptococcus mutans strains |
| 红细胞质膜钙ATP酶（PMCA4b）的变异通过介导氧化还原失衡来决定疟疾对青蒿素的敏感性。 |
Agrohi, P. |
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N/A |
Erythrocytic plasma membrane calcium ATPase (PMCA4b) variations mediate redox imbalance to determine artemisinin sensitivity in malaria |
| 通过重构外膜蛋白BamA来杀死革兰氏阴性菌的抗生素 |
Modaresi, S. M. |
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N/A |
Antibiotics that Kill Gram-negative Bacteria by Restructuring the Outer Membrane Protein BamA |
| Mbd4和MutSα保护细胞免受5-甲基胞嘧啶自发脱氨基的影响。 |
Bilardi, R. A. |
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N/A |
Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine. |
| DUX4诱导的HSATII RNA积累驱动蛋白质聚集，影响RNA加工途径。 |
Arends, T. |
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N/A |
DUX4-induced HSATII RNA accumulation drives protein aggregation impacting RNA processing pathways. |
| 将CRISPR扫描与靶向染色质可及性分析相结合，使用双链DNA脱氨酶 |
Roh, H. |
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N/A |
Coupling CRISPR Scanning with Targeted Chromatin Accessibility Profiling using a Double-Stranded DNA Deaminase |
| 随机生长爆发使单个细菌能够无负担地生产鞭毛 |
Garcia-Alcala, M. |
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N/A |
Stochastic Growth Bursts Enable Burden-Free Flagellum Production in a Single Bacterium |
| 果蝇Bam和Bgcn序列的比较分析及预测的蛋白质结构进化 |
Arnce, L. |
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N/A |
Comparative Analysis of Drosophila Bam and Bgcn Sequences and Predicted Protein Structural Evolution |
| 转座元件驱动F-box基因的调控和功能创新 |
Almeida, M. V. |
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N/A |
Transposable elements drive regulatory and functional innovation of F-box genes |
| 哺乳动物中转座元件的剂量补偿 |
Wei, C. |
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N/A |
Dosage compensation of transposable elements in mammals |
| D型细胞周期蛋白被AMBRA1 E3连接酶受体识别的机制 |
Wang, Y. |
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N/A |
Mechanism of D-type cyclins recognition by the AMBRA1 E3 ligase receptor |
| 从基因组语言模型中对功能性新生基因进行语义挖掘 |
Merchant, A. T. |
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N/A |
Semantic mining of functional de novo genes from a genomic language model |
| 一个可热插拔的遗传开关：构建一个对必需基因MEDIATOR 21的可诱导且可追踪的功能性检测 |
Watson, I. J. |
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N/A |
A Hot-Swappable Genetic Switch: Building an inducible and trackable functional assay for the essential gene MEDIATOR 21 |
| 对代谢组学数据的重新分析揭示，微生物群移植疗法能够调节自闭症谱系障碍儿童的粪便和血浆代谢物特征。 |
Nirmalkar, K. |
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N/A |
Reanalysis of metabolomics data reveals that microbiota transfer therapy modulates important fecal and plasma metabolite profiles in children with autism spectrum disorders |
| 丙酮酸激酶在糖酵解过程中直接生成GTP，支持细胞生长并参与鸟苷毒性作用。 |
She, F. |
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N/A |
Pyruvate Kinase Directly Generates GTP in Glycolysis, Supporting Growth and Contributing to Guanosine Toxicity |
| 社会任务和攻击性塑造了高度社会性蜜蜂头部中的免疫基因表达水平。 |
Campana, L. |
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N/A |
Social task and aggressiveness shape immunity gene expression levels in the head of highly eusocial bees |
| 非洲霍乱弧菌分离株的基因组多样性和抗菌药物耐药性：一项利用纳米孔测序技术加强基因组监测的PulseNet Africa计划 |
Foster-Nyarko, E. |
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N/A |
Genomic Diversity and Antimicrobial Resistance of Vibrio cholerae Isolates from Africa: A PulseNet Africa Initiative Using Nanopore Sequencing to Enhance Genomic Surveillance |
| 利用DNA纳米结构对生化反应进行空间条码编码揭示了邻近标记中的主要接触机制。 |
Yang, Z. |
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N/A |
Spatially barcoding biochemical reactions using DNA nanostructures unveil a major contact mechanism in proximity labeling |
| 在结直肠癌中模拟奥沙利铂耐药性揭示了基于SERPINE1的基因特征（RESIST-M）及针对促转移CMS4亚型的治疗策略 |
Wong, S. Q. R. |
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N/A |
Modelling oxaliplatin resistance in colorectal cancer reveals a SERPINE1-based gene signature (RESIST-M) and therapeutic strategies for pro-metastatic CMS4 subtype |
| MADS-box基因家族在微调塔罗霉素马尔内菲（Talaromyces marneffei）双态转变中的功能多样化 |
Hu, X. |
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N/A |
Functional diversification of the MADS-box gene family in fine-tuning the dimorphic transition of Talaromyces marneffei |
| 冠心病与糖尿病之间的差异代谢生物标志物 |
Wang, Z. |
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N/A |
Differential metabolic biomarkers between coronary heart disease and diabetes mellitus |
| 主要组织相容性复合体：真菌疾病易感性中的双刃剑 |
FU, M. |
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N/A |
The major histocompatibility complex: a double-edged sword in fungal disease susceptibility |
| 直接表达CPT1a能够实现一个高通量的平台，用于发现CPT1a的调节剂。 |
Chen, J. |
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N/A |
Direct expression of CPT1a enables a high throughput platform for the discovery of CPT1a modulators |
| 生成专家指导的、简化的本体论视图的一般策略 |
Caron, A. R. |
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N/A |
A general strategy for generating expert-guided, simplified views of ontologies |
| CoPPIs算法：揭示病理生理条件下蛋白质协同策略的工具 |
Lomagno, A. |
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N/A |
CoPPIs Algorithm: A Tool to Unravel Protein Cooperative Strategies in Pathophysiological Conditions |
| 突触易化增强了高频神经传递的可靠性和精确性。 |
Bernal-Correa, A. M. |
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N/A |
Synaptic facilitation enhances the reliability and precision of high frequency neurotransmission |
| 当存在背叛者时，互惠合作可以稳定，因为这促使了歧视行为的出现。 |
Roberts, G. |
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N/A |
Reciprocal cooperation can be stable when the presence of defectors selects for discrimination |
| 杜氏肌营养不良症中早期内体紊乱与内溶酶体途径功能障碍 |
Chassagne, J. |
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N/A |
Early endosome disturbance and endolysosomal pathway dysfunction in Duchenne muscular dystrophy |
| 通过肌节分裂实现肌肉增长 |
Rodier, C. |
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N/A |
Muscle growth by sarcomere divisions |
| 在成年斑马鱼心脏再生过程中，受损的心内膜获得了造血内皮细胞的特性。 |
Ying, J. |
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N/A |
Injured endocardium obtains characteristics of haemogenic endothelium during adult zebrafish heart regeneration |
| 褪黑素调控Nrf2/HO-1通路对甲醛暴露所致急性肺损伤的潜在机制及效应 |
Wang, B. |
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N/A |
Potential mechanisms and effects of melatonin-regulated Nrf2/HO-1 pathway on acute lung injury due to formaldehyde exposure |
| 一个用于评估单只果蝇学习和记忆的高通量平台：个体果蝇嗅觉条件化器（iDOC） |
Ortega, A. |
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N/A |
A High-Throughput Platform for Assessing Single Fly Learning and Memory: Individual Drosophila Olfactory Conditioner (iDOC) |
| 运动与即时听觉反馈相结合如何影响大鼠的自发行为？ |
Yoshida, K. |
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N/A |
How does immediate auditory feedback coupled to locomotion influence the spontaneous actions of rats? |
| 细胞外囊泡RNA具有糖基化修饰 |
Sharma, S. |
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N/A |
Extracellular Exosomal RNAs are Glyco-Modified |
| 多泛素化的跨膜蛋白在网格蛋白包被的小泡内部有限的容纳空间中，能够胜过其他货物蛋白。 |
Liu, H.-Y. |
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N/A |
Poly-ubiquitylated transmembrane proteins outcompete other cargo for limited space inside clathrin-coated vesicles |
| 一项CRISPR/Cas9筛选揭示了位于内体-高尔基体界面并调控细胞ASO活性的蛋白质 |
Malong, L. |
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N/A |
A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular ASO activity |
| 过度活跃的PLCG1驱动非经典信号传导以促进细胞存活 |
Zeng, L. |
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N/A |
Hyperactive PLCG1 drives non-canonical signaling to promote cell survival |
| 年龄和性别在人类初级肌细胞中的转录组特征并不保守。 |
Lamon, S. |
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N/A |
The transcriptomic signature of age and sex is not conserved in human primary myocytes |
| M2巨噬细胞表达的TGF-β通过抑制间充质干细胞的TSG-6表达来促进伤口愈合。 |
Eom, Y. W. |
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N/A |
TGF-β expressed by M2 macrophages promotes wound healing by inhibiting TSG-6 expression by mesenchymal stem cells |
| ABHD2活性对于孕酮在人类精子上的非基因组作用并非必需。 |
Arnolds, O. |
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N/A |
ABHD2 activity is not required for the non-genomic action of progesterone on human sperm |
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Davies, I. |
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N/A |
The physiological impact of an N-terminal Halo-tag on GIPR function in mice |
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Yaple-Maresh, M. E. |
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N/A |
Virus-induced vesicular acidification enhances HIV immune evasion. |
| 年轻男性在八小时极端高温暴露期间的液体补充与急性全身炎症反应综合征 |
Wang, F. |
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N/A |
Fluid replacement and acute systemic inflammatory response syndrome during eight-hour extreme heat exposure in young men |
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Tanaka, R. |
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N/A |
Mechanisms for plastic landmark anchoring in zebrafish compass neurons |
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Chen, H.-C. |
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N/A |
UTX Epigenetically Imposes a Cytolytic Effector Program in Autoreactive Stem-like CD8+ T cell Progenitors |
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Jamshed, L. |
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N/A |
Distinct DNA Methylation Signatures in Maternal Blood Reveal Unique Immune Cell Shifts in Preeclampsia and the Pregnancy-Postpartum Transition |
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Wray, J. |
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N/A |
The diffusion of cooperative and solo bubble net feeding in Canadian Pacific humpback whales |
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Jin, H. |
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N/A |
Domain Structure and Interface Control of Mechanical Stiffness in Sustainable Cellulose Bio-nanocomposites |