| 一个从生理特征预测人类生物学年龄的数学模型，揭示了影响衰老的环境和遗传因素。 |
Libert, S. |
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N/A |
A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging |
| 小鼠体内电生理测量的可重复性 |
The International Brain Laboratory, |
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N/A |
Reproducibility of in-vivo electrophysiological measurements in mice |
| 表面信号网络的拓扑学研究及其对神经动力学的可能影响 |
Sen, S. |
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N/A |
A Topological Study of a Surface Signaling Network and Possible Implications for Neural Dynamics |
| 全面分析通过鼻腔给药诱导的SARS-CoV-2刺突蛋白鼻IgA抗体 |
Waki, K. |
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N/A |
Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein |
| 一张复杂行为期间大脑神经活动全图 |
International Brain Lab, |
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N/A |
A Brain-Wide Map of Neural Activity during Complex Behaviour |
| 一张复杂行为过程中大脑神经活动的全面图谱 |
International Brain Lab, |
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N/A |
A Brain-Wide Map of Neural Activity during Complex Behaviour |
| 根据色彩空间的对称性预测色彩匹配实验中的反应 |
Vattuone, N. |
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N/A |
Predicting the responses in colour matching experiments from the symmetries of colour space |
| 阿克曼菌（Akkermansia muciniphila）被鉴定为通过Wnt信号通路缓解肠道屏障损伤的关键菌株。 |
Ma, X. |
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N/A |
Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway |
| 从Seven Springs，Martlesham，萨福克的新石器时代早期森林耕作，通过沉积物DNA和花粉推断。 |
Hudson, S. M. |
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N/A |
Early Neolithic forest farming at Seven Springs, Martlesham, Suffolk inferred from sedaDNA and pollen |
| 综合分析揭示吡维氯铵在默克尔细胞癌中的治疗潜力 |
Yang, J. |
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N/A |
Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma |
| 普罗克鲁斯提恩图：一种用于快速k-mer大小分析的子串索引 |
Park, A. |
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N/A |
Prokrustean Graph: A substring index for rapid k-mer size analysis |
| 基于聚光灯的逐试次fMRI解码在存在试次间相关性的情况下 |
Soch, J. |
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N/A |
Searchlight-based trial-wise fMRI decoding in the presence of trial-by-trial correlations |
| ERK、JNK和p38 MAP激酶对连接蛋白43的差异性底物特异性 |
Latchford, L. P. |
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Differential substrate specificity of ERK, JNK, and p38 MAP kinases toward Connexin 43 |
| 幼年斑马鱼通过多感官控制姿势和运动来维持高度 |
Davis, S. N. |
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N/A |
Larval zebrafish maintain elevation with multisensory control of posture and locomotion |
| iPAR：一种用于真核细胞质蛋白聚集的新型报告分子 |
Lecinski, S. |
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N/A |
iPAR: a new reporter for eukaryotic cytoplasmic protein aggregation |
| 一个关于Ca2+/钙调蛋白依赖性蛋白激酶II（CaMKII）自磷酸化的空间模型预测，通过钙调蛋白捕获，突触可塑性诱导后磷酸化CaMKII的寿命会大大延长。 |
Bartol, T. M. |
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N/A |
A spatial model of autophosphorylation of Ca2+/calmodulin-dependent proteinkinase II (CaMKII) predicts that the lifetime of phospho-CaMKII after induction ofsynaptic plasticity is greatly prolonged by CaM-trapping. |
| 全长BEND2蛋白对小鼠的精子发生并非必需，但在调节卵巢储备方面是必需的。 |
Huang, Y. |
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The full length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice |
| 社会接触塑造了裸鼹鼠的交流和动物识别能力。 |
Schwark, R. |
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N/A |
Social touch shapes communication and animal recognition in naked mole-rats |
| 莫努匹拉韦和奈玛特韦对COVID-19重症模型中SARS-CoV-2基因组多样性的影响。 |
Penrice-Randal, R. |
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N/A |
The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19. |
| 鉴定可药物结合位点和小分子作为TMC1的调节剂 |
De-la-Torre, P. |
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N/A |
Identification of Druggable Binding Sites and Small Molecules as Modulators of TMC1 |
| 探索感染性非编码环状RNA中的RNA修饰 |
Vopalensky, P. |
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N/A |
Exploring RNA modifications in infectious non-coding circular RNAs |
| 白蚁基因组中出乎意料的低重组率和热点存在 |
Everitt, T. |
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N/A |
Unexpectedly low recombination rates and presence of hotspots in termite genomes |
| 脊髓运动神经元的兴奋性通过β-肾上腺素能神经调节在野生型和症状前SOD1小鼠中进行稳态调控。 |
Antonucci, S. |
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N/A |
Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice |
| 评估化学方法去除艰难梭菌孢子外壳和外孢子层的效果 |
Sanchez-Peralta, J. |
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N/A |
Assessment of chemical methods in the removal of the spore coat and exosporium layers of Clostridioides difficile Spores |
| 受体细胞通过旁分泌粘附信号促进对小细胞外囊泡的摄取。 |
Hirosawa, K. M. |
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N/A |
The uptake of small extracellular vesicles by recipient cells is facilitated by paracrine adhesion signaling |
| PAbFold：使用AlphaFold2进行线性抗体表位预测 |
DeRoo, J. |
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N/A |
PAbFold: Linear Antibody Epitope Prediction using AlphaFold2 |
| MSLASpheroidStamp：为每个人提供3D细胞球体 |
Minin, A. S. |
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N/A |
MSLASpheroidStamp: 3d cell spheroids for everyone |
| 在估计群体平均多基因评分历史的背景下评估ARG估计方法 |
Peng, D. |
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N/A |
Evaluating ARG-estimation methods in the context of estimating population-mean polygenic score histories |
| 在循环神经网络模型中，Hebbian可塑性导致了多种感知偏差的产生。 |
Schönsberg, F. |
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N/A |
Diverse perceptual biases emerge from Hebbian plasticity in a recurrent neural network model |
| 发现并机制表征了一种源自益生菌的3β-OH-Δ5-6-胆固醇-5β-还原酶，可直接将胆固醇转化为粪甾醇 |
Netter, U. |
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N/A |
Discovery and mechanistic characterization of a probiotic-origin 3β-OH-Δ5-6-cholesterol-5β-reductase directly converting cholesterol to coprostanol |
| UNC-6/Netrin 在单个轴突内同时促进粘附和定向生长 |
Nichols, E. L. |
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UNC-6/Netrin promotes both adhesion and directed growth within a single axon |
| 听觉皮层中音高感知的动力学 |
Abrams, E. B. |
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N/A |
Dynamics of pitch perception in the auditory cortex |
| 用于人类大脑及其他生物模型的关联光学与电子显微镜技术 |
Shafiei, N. |
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N/A |
Correlative light and electron microscopy for human brain and other biological models |
| 通过深度神经网络中的分类嵌入优化药物协同预测 |
Gonzalez Lastre, M. |
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N/A |
Optimizing drug synergy prediction through categorical embeddings in Deep Neural Networks |
| AI辅助解析分子特征，这些特征对于非向光性下胚轴3的凝聚及其在向光性中的功能至关重要。 |
Manishankar, P. |
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N/A |
AI-assisted decoding of molecular signatures essential for NON-PHOTOTROPIC HYPOCOTYL3 condensation and function in phototropism |
| 通过招募关键免疫细胞在可注射水凝胶储库中生成炎症微环境，可提高mRNA疫苗的效力。 |
Meany, E. L. |
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Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines |
| 人类有目标的行动准备涉及皮质脊髓神经计算的混合过程。 |
Wadsley, C. G. |
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N/A |
Goal-directed action preparation in humans entails a mixture of corticospinal neural computations |
| 肌肉和肠道的innexins与肌肉的Deg/Enac通道共同促进肌肉协调和胚胎延长。 |
LLENSE, F. |
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N/A |
Muscle and intestine innexins with muscle Deg/Enac channels promote muscle coordination and embryo elongation |
| 性依赖性胃肠道定植抗性对MRSA的抵抗是依赖于微生物群和Th17的 |
Lejeune, A. |
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Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent |
| 组织坏死后的再生过程是通过非凋亡性caspase活性介导的。 |
Klemm, J. |
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N/A |
Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity |
| 神经肽Sulfakinin是一种外周调节因子，能够调控昆虫在交配和觅食行为之间的转换。 |
Li, H.-F. |
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N/A |
The Neuropeptide Sulfakinin, a peripheral regulator of insect behavior switch between mating and foraging |
| 基于质心功分析估计首选步行速度 |
Hosseini-Yazdi, S.-S. |
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N/A |
Estimating the Preferred Walking Speeds Based on the Center of Mass Work Analysis |
| 新开发的基于结构的分析方法在大规模系统发育分析中并未优于标准的基于序列的分析方法。 |
Mutti, G. |
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N/A |
Newly developed structure-based methods do not outperform standard sequence-based methods for large-scale phylogenomics |
| 突触细胞粘附分子Cdh6识别出一类具有结肠运动新功能的感觉神经元 |
Gomez-Frittelli, J. |
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Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility |
| 在存在基因重复的情况下，进行系统基因组学预测的相互作用网络 |
Forsythe, E. S. |
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N/A |
Phylogenomic prediction of interaction networks in the presence of gene duplication |
| 物候特征的协同进化塑造了植物-传粉者共存 |
Duchenne, F. |
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N/A |
Coevolution of phenological traits shapes plant-pollinator coexistence |
| 黑腹果蝇（Drosophila melanogaster）的色素沉着在多个时间尺度上展示了适应性表型平行现象。 |
Berardi, S. |
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N/A |
Drosophila melanogaster pigmentation demonstrates adaptive phenotypic parallelism over multiple timescales |
| 图像引导的线粒体代谢靶向增强了儿童恶性横纹肌样瘤对低剂量放疗的敏感性 |
Xia, W. |
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N/A |
Image-Guided Targeting of Mitochondrial Metabolism Sensitizes Pediatric Malignant Rhabdoid Tumors to Low Dose Radiotherapy |
| 序列动作表征在快速技能学习过程中进行情境化处理。 |
Dash, D. |
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N/A |
Sequence action representations contextualize during rapid skill learning |
| 评估森林管理与气候变化对欧洲山毛榉森林碳和水通量的综合影响 |
Saponaro, V. |
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N/A |
Assessing the combined effects of forest management and climate change on carbon and water fluxes in European beech forests |
| 编排不可能的化学反应：依赖B12的甲硫氨酸合成酶催化过程的结构快照 |
Mendoza, J. |
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N/A |
Orchestrating Improbable Chemistries: Structural Snapshots of B12-Dependent Methionine Synthase's Catalytic Choreography |
| 空间结构通过药物抗性促进进化救援 |
Fruet, C. |
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N/A |
Spatial structure facilitates evolutionary rescue by drug resistance |
| 一种FUCCI传感器揭示了弓形虫内二芽殖的复杂细胞周期组织 |
Batra, M. |
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N/A |
A FUCCI sensor reveals complex cell cycle organization of Toxoplasma endodyogeny |
| 计算癌症治疗的斯塔克尔伯格均衡 |
Ganzfried, S. |
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N/A |
Computing Stackelberg Equilibrium for Cancer Treatment |
| 在细胞分化过程中，Caspase激活的脱氧核糖核酸酶（DNase）定位于导致癌症的易位断裂点 |
Alsowaida, D. |
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N/A |
Caspase-Activated DNase Localizes to Cancer Causing Translocation Breakpoints During Cell Differentiation |
| 联合PARP14抑制与PD-1阻断促进复发性黑色素瘤中细胞毒性T细胞的静息状态并调节巨噬细胞极化 |
Leshem, R. |
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N/A |
Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarisation in Relapsed Melanoma |
| 生物学启发的皮层模型预测光遗传学扰动 |
Sourmpis, C. |
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N/A |
Biologically informed cortical models predict optogenetic perturbations |
| 从头设计能够结合萘二酰亚胺的蛋白质，萘二酰亚胺是一种具有可调光物理性质的强大光氧化剂。 |
Mann, S. I. |
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N/A |
De novo design of proteins that bind naphthalenediimides, powerful photooxidants with tunable photophysical properties |
| 映射布尔网络的吸引子景观 |
Trinh, V.-G. |
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N/A |
Mapping the attractor landscape of Boolean networks |
| 神经运动生成的背后空间和网络原理 |
Komi, S. |
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N/A |
Spatial and network principles behind neural generation of locomotion |
| 通过编码流形揭示的小鼠视觉皮层区域的功能组织与自然场景响应 |
Dyballa, L. |
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N/A |
Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds |
| 气候变化、天气和地理因素共同塑造了整个北美西部种子质量的变化和下降趋势。 |
Lenzo, L. |
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N/A |
Climate change, weather, and geography shape seed mass variation and decline across western North America |
| 来自产气荚膜梭菌的IV型菌毛相关分泌的一种生物膜基质蛋白，该蛋白通过形成分子间异肽键来发挥作用。 |
Kivimaki, S. E. |
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N/A |
Type IV pili-associated secretion of a biofilm matrix protein from Clostridium perfringens that forms intermolecular isopeptide bonds |
| 基于逻辑的机器学习预测艾司西酞普兰如何减轻心肌细胞肥大 |
Eggertsen, T. G. |
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N/A |
Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy |
| 两亲性螺旋通过脂质堆积缺陷感知内核膜环境 |
Lee, S. |
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N/A |
Amphipathic helices sense the inner nuclear membrane environment through lipid packing defects |
| 回到角的问题：通过不同类型的重组事件重建祖先角的原始状态。 |
Upadhyay, M. |
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N/A |
Back to the horns: a reconstruction of the ancestral horn state through distinct types of recombination events. |
| 一个从3446张全切片图像中通过自监督学习发现的切除间皮瘤的组织形态学图谱 |
Seyedshahi, F. |
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N/A |
A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images |
| 植物易感性的组织依赖性：通过根部和叶片对系统性植物病原菌Ralstonia pseudosolanacearum在茄子和番茄幼苗中的致病性比较研究 |
Bhuyan, S. |
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N/A |
Tissue-dependent nature of plant susceptibility: a comparative pathogenicity study of the systemic phytopathogen Ralstonia pseudosolanacearum in eggplant and tomato seedlings through root and leaf |
| 经过工程改造的CRISPR-Base编辑器：家族性自主神经异常的永久性治疗方法 |
Yun, S. |
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N/A |
Engineered CRISPR-Base Editors as a Permanent Treatment for Familial Dysautonomia |
| 宫颈阴道微生物特征可预测感染女性沙眼衣原体向上生殖道的传播 |
Jeong, S. |
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N/A |
Cervicovaginal microbial features predict Chlamydia trachomatis spread to the upper genital tract of infected women |
| 秀丽隐杆线虫的huntingtin蛋白，即htt-1，在应激条件下能够促进强效的自噬诱导并提高生存率。 |
Chung, C. H. |
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N/A |
C. elegans huntingtin, htt-1, promotes robust autophagy induction and survival under stress conditions |
| 芯片上流体诱导的血管重塑：对抗VEGF疗法的启示 |
Mirzapour-Shafiyi, F. |
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N/A |
Flow-Induced Vascular Remodeling On-Chip: Implications for Anti-VEGF Therapy |
| 扩展HP1a结合的共识序列和异染色质组装的分子语法 |
Colmenares, S. U. |
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N/A |
Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly |
| 使用AlphaFold2预测肽的结构构象 |
Ille, A. M. |
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N/A |
Prediction of peptide structural conformations with AlphaFold2 |
| 自发脑活动背后的神经受体和转运蛋白 |
Nakuci, J. |
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N/A |
The neuroreceptors and transporters underlying spontaneous brain activity |
| 捕食者与猎物互动中的诚实信号：检验资源分配假说 |
Burdfield-Steel, E. |
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N/A |
Honest signalling in predator-prey interactions: testing the resource allocation hypothesis |
| 果蝇（Drosophila melanogaster）头部基因表达随年龄变化的动态变化 |
Hanson, K. M. |
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N/A |
Dynamic Changes in Gene Expression Through Aging in Drosophila melanogaster Heads |
| 形态发生约束在类原肠胚发育中的作用：对小鼠原肠形成的影响 |
Fiuza, U.-M. |
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N/A |
Morphogenetic constrains in the development of gastruloids: implications for mouse gastrulation |
| NRBP1假激酶在渗透压应激下结合并激活WNK通路。 |
Amnekar, R. |
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N/A |
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress |
| 锥体细胞和中间神经元在尖波波纹的作用下被强烈地重新激活。 |
Javed, M. H. |
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N/A |
cfos principal cells and interneurons are strongly reactivated by sharp wave ripples |
| 斑马鱼罗盘神经元中塑料地标锚定的机制 |
Tanaka, R. |
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N/A |
Mechanisms for plastic landmark anchoring in zebrafish compass neurons |
| UTX通过表观遗传方式在自身反应性干细胞样CD8+ T细胞前体中强制执行一种细胞溶解效应程序。 |
Chen, H.-C. |
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N/A |
UTX Epigenetically Imposes a Cytolytic Effector Program in Autoreactive Stem-like CD8+ T cell Progenitors |
| 对不同海葵物种的毒素基因家族进行了比较分析 |
Smith, H. L. |
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N/A |
A comparative analysis of toxin gene families across diverse sea anemone species |
| EpiPAMPAS：通过简约祖先状态重建和计数突变快速检测蛋白质内上位性 |
Dabbaghie, F. |
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N/A |
EpiPAMPAS: Rapid detection of intra-protein epistasis via parsimonious ancestral state reconstruction and counting mutations |
| 将机械敏感离子通道Piezo进行靶向和锚定，以促进其对轴突再生的抑制作用 |
Song, Y. |
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N/A |
Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration |
| 随机连接性产生了抑制性微电路，这些微电路在视觉皮层中解除了适应的相关性。 |
Kosiachkin, Y. |
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N/A |
Random connectivity generates inhibitory microcircuits that decorrelate adaptation in visual cortex |
| 错失眼前之物：人类在食欲性和厌恶性听觉-嗅觉条件反射中的失败 |
Menger, N. S. |
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N/A |
Missing what is right under your nose: failed appetitive and aversive audio-olfactory conditioning in humans |
| 在寿命和衰老研究中，Kolmogorov-Smirnov和Shapiro-Wilk单分布分析方法用于检验样本结构、遗传背景的强度以及干预措施的效果。 |
Konopatov, A. V. |
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N/A |
Kolmogorov-Smirnov and Shapiro-Wilk single distribution analysis methods in examining sample structure, strength of genetic background, and effects of interventions in lifespan and aging studies |
| 通过Orbitrap星型质谱和串联质量标签（TMT）整合扩展衰老研究领域 |
Keele, G. R. |
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N/A |
Expanding the Landscape of Aging via Orbitrap Astral Mass Spectrometry and Tandem Mass Tag (TMT) Integration |
| 通过获得性功能突变进行的代谢重编程克服了金黄色葡萄球菌中plsX基因的必需性。 |
Gruss, A. |
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N/A |
Metabolic rerouting by gain-of-function mutations overcomes plsX essentiality in Staphylococcus aureus |
| 链球菌M3蛋白识别胶原蛋白的结构基础及其在生物膜形成中的作用 |
Wojnowska, M. |
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N/A |
Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm |
| 解锁一种栽培巨型噬菌体的基因组序列 |
Buchan, A. |
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N/A |
Unlocking the genomic repertoire of a cultivated megaphage |
| 病毒RNA的假结结构揭示了一种保守的机制，用于抵抗程序性外切核酸酶的降解。 |
Gezelle, J. G. |
PDF |
N/A |
The pseudoknot structure of a viral RNA reveals a conserved mechanism for programmed exoribonuclease resistance |
| 通用接受系统作为一种新型调节器，在白细胞生成抗菌和抗癌生物活性化合物的过程中发挥作用。 |
Tetz, V. |
PDF |
N/A |
The Universal Receptive System acts as a novel regulator in the production of antimicrobial and anticancer bioactive compounds by white blood cells |
| 犬类衰老项目中伴侣犬的首个共病网络 |
Fang, A. |
PDF |
N/A |
The first comorbidity networks in companion dogs in the Dog Aging Project |
| 多物种关系塑造了鸟类喂养行为。 |
Aivelo, T. |
PDF |
N/A |
Multispecies relations shape bird-feeding practices |
| 传染病动力学研究中性别和种族/民族失衡的程度及驱动因素 |
Taube, J. C. |
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N/A |
The extent and drivers of gender and race/ethnicity imbalance in infectious disease dynamics research |
| 使用德尔菲法为非专业入门生物学制定学习目标的发展 |
Brickman, P. |
PDF |
N/A |
Development of Learning Objectives for Non-Major Introductory Biology Using a Delphi Method |
| StreptoCAD：一种开源软件工具箱，用于自动化链霉菌中的基因组工程工作流程 |
Levassor, L. |
PDF |
N/A |
StreptoCAD: An open-source software toolbox automating genome engineering workflows in streptomycetes |
| 急性至慢性疼痛特征（A2CPS）项目中的图像处理 |
Sadil, P. |
PDF |
N/A |
Image Processing in the Acute to Chronic Pain Signatures (A2CPS) Project |
| 新西兰患有特发性生长不良综合征的牧场牛只的口腔和粪便病毒组 |
Grimwood, R. M. |
PDF |
N/A |
Oral and faecal viromes of New Zealand calves on pasture with an idiopathic ill-thrift syndrome |
| 早期抗生素和益生菌治疗对极低出生体重早产儿肠道微生物群和抗性组的影响 |
Kiu, R. |
PDF |
N/A |
Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants |
| Viro3D：一个全面的病毒蛋白结构预测数据库 |
Litvin, U. |
PDF |
N/A |
Viro3D: a comprehensive database of virus protein structure predictions |
| 血管内皮生长因子D在急性肺损伤期间改善肺血管完整性 |
Yuan, Y. |
PDF |
N/A |
Vascular endothelial growth factor-D improves lung vascular integrity during acute lung injury |
| 在甲藻物种中细胞穿透肽的转运 |
Gorrie, D. M. |
PDF |
N/A |
Cell-Penetrating Peptide Translocation in Haptophyte Species |
| 染色体周围区域是卵母细胞染色体的重要组成部分。 |
Simpson, E. L. |
PDF |
N/A |
The Chromosome Periphery is an Essential Compartment of Oocyte Chromosomes |
| 空间扰动测序（Spatial Perturb-Seq）：在完整组织结构中进行单细胞功能基因组学研究 |
Shen, K. |
PDF |
N/A |
Spatial Perturb-Seq: Single-Cell Functional Genomics within Intact Tissue Architecture |
| Remodelin对小鼠肌细胞分化的抑制作用 |
Sian, V. |
PDF |
N/A |
The inhibitory effects of Remodelin on murine myoblasts differentiation |
| DNAJC13定位于内体的过程受到其J结构域及其无序C端尾部的对抗。 |
Adoff, H. |
PDF |
N/A |
DNAJC13 localization to endosomes is opposed by its J domain and its disordered C-terminal tail |
| 在曲霉菌感染期间，肺成纤维细胞的激活通过免疫调节和组织重塑增强了肺部防御。 |
Guirao-Abad, J. P. |
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N/A |
Pulmonary fibroblast activation during Aspergillus fumigatus infection enhances lung defense via immunomodulation and tissue remodeling |
| 秀丽隐杆线虫核仁中的RG重复序列足以实现核仁积累，但不足以实现核仁亚区室的划分。 |
Spaulding, E. L. |
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N/A |
C. elegans nucleolar RG repeats are sufficient for nucleolar accumulation but insufficient for sub-nucleolar compartmentalization |
| 蝾螈大脑中的神经元激活促进了脊髓再生 |
Walker, S. |
PDF |
N/A |
Neuronal activation in the axolotl brain promotes spinal cord regeneration |
| Wnt通路的调控对于在颅神经管闭合过程中正确执行多个独立的细胞动态程序是必需的。 |
Bogart, A. H. |
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N/A |
Wnt pathway modulation is required to correctly execute multiple independent cellular dynamic programs during cranial neural tube closure |
| 微生物组介导性状的定量遗传学 |
Week, B. |
PDF |
N/A |
Quantitative Genetics of Microbiome Mediated Traits |
| 调控金鱼望远眼和天眼发育的LRP2基因的平行进化 |
Li, R. |
PDF |
N/A |
Parallel evolution of LRP2 gene mediating telescope-eye and celestial-eye in goldfish |
| 低温电子断层扫描与线粒体颗粒的元素分析在人类视网膜神经节细胞中的应用 |
Wu, G.-H. |
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N/A |
Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells |
| 解决人类AMPylase FicD的TPR结构域中构象状态的动态相互作用 |
Runge, S. |
PDF |
N/A |
Resolving the Dynamic Interplay of the Conformational States in the TPR Domain of Human AMPylase FicD |
| CSF1R-CAR T细胞诱导CSF1R信号传导并促进癌细胞生长。 |
Callahan, A. |
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N/A |
CSF1R-CAR T cells induce CSF1R signalling and promote cancer cell growth |
| 非经典葡萄糖代谢重编程使癌细胞对靶向疗法产生抗性 |
Zhu, L. |
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N/A |
A non-canonical glucose metabolic rewiring enables resistance to cancer targeted therapy |
| 肌动蛋白失调通过氧化应激激活的PD-L1在胃癌中引发免疫逃逸 |
Seo, Y. |
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N/A |
Actin dysregulation induces immune evasion via oxidative stress-activated PD-L1 in gastric cancer |
| 更简单的预测模型在卵巢癌检测中提供了更高的准确性。 |
Wood, D. E. |
PDF |
N/A |
Simpler predictive models provide higher accuracy for ovarian cancer detection |
| 衰老突触：蛋白质组学与转录组学综合分析 |
Caterino, C. |
PDF |
N/A |
The Aging Synapse: An Integrated Proteomic And Transcriptomic Analysis |
| Syngap1与小鼠新皮质祖细胞的发育 |
Barao, S. |
PDF |
N/A |
Syngap1 and the development of murine neocortical progenitor cells |
| 研究鞘磷脂酶对胞外囊泡货物分选的影响 |
Padilla, J.-C. A. |
PDF |
N/A |
Investigating the Impacts of Sphingomyelinases on Extracellular Vesicle Cargo Sorting |
| 磷脂酰肌醇-3,5-二磷酸介导的液泡形态调节是乙醇胁迫反应的重要组成部分。 |
Mandal, P. |
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N/A |
Phosphatidylinositol-3,5-bisphosphate mediated vacuolar morphology modulation is integral to ethanol stress response |
| 拟南芥14-3-3蛋白通过稳定质膜上的油菜素内酯不敏感1（BRASSINOSTEROID INSENSITIVE1）来正向调控油菜素内酯信号传导。 |
Liu, D. |
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N/A |
The Arabidopsis 14-3-3 proteins positively regulate brassinosteroid signaling by stabilizing BRASSINOSTEROID INSENSITIVE1 at the plasma membrane |
| 细胞周期中的核代谢振荡揭示了磷脂酰肌醇途径与组蛋白甲基化之间的联系。 |
Ganez-Zapater, A. |
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N/A |
Nuclear metabolism oscillation during the cell cycle reveals a link between the phosphatidylinositol pathway and histone methylation. |
| NUAK1调控源自腹主动脉瘤患者的血管平滑肌细胞的收缩。 |
Rombouts, K. B. |
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N/A |
NUAK1 regulates contraction in vascular smooth muscle cells derived from abdominal aortic aneurysm patients |
| 利用360度视频和空间音频解读珊瑚礁声音景观 |
Dantzker, M. S. |
PDF |
N/A |
Deciphering Coral Reef Soundscapes Utilizing 360 Video and Spatial Audio |
| 抑制果蝇（Drosophila melanogaster）着丝粒异染色质中的减数分裂交叉需要联会复合体和减数分裂重组因子 |
Pazhayam, N. M. |
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N/A |
Suppression of meiotic crossovers in pericentromeric heterochromatin requires synaptonemal complex and meiotic recombination factors in Drosophila melanogaster |
| 用于检测三联重复序列扩展的TRX检测方法 |
O'Brien, T. |
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N/A |
The TRX assay for triplet repeat expansions |
| 电场诱导的人类Kv2.1通道孔收缩 |
Mandala, V. S. |
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N/A |
Electric field-induced pore constriction in the human Kv2.1 channel |
| DTPSP：一种用于时间序列单细胞研究中优化时间点选择的深度学习框架 |
Hijazin, M. |
PDF |
N/A |
DTPSP: A Deep Learning Framework for Optimized Time Point Selection in Time-Series Single-Cell Studies |
| 一种全3D打印的低成本组织学成像光学显微镜 |
Christopher, J. |
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N/A |
A fully 3D-printed optical microscope for low-cost histological imaging |
| 富含芳香族残基的带电肽减缓了由交叉β-折叠形成驱动的凝聚物老化过程。 |
Sanchez-Burgos, I. |
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N/A |
Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-beta-sheet formation |
| GlioME：一种保留胶质瘤微环境的新型类器官模型，用于个性化药物筛选和治疗评估 |
Zheng, C. |
PDF |
N/A |
GlioME: A Novel Organoid Model Retaining the Glioma Mi-croenvironment for Personalized Drug Screening and Thera-peutic Evaluation |
| 靶向从头脂质生成可提高胰腺导管腺癌中吉西他滨的疗效 |
Hancock, S. E. |
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N/A |
Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma |
| 一个结合了低氧、机械感应和TGF-β信号传导的布尔网络模型，揭示了表型可塑性和突变在肿瘤转移中的作用。 |
Greene, G. |
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N/A |
A Boolean network model of hypoxia, mechanosensing and TGF-β signaling captures the role of phenotypic plasticity and mutations in tumor metastasis |
| 代谢组学分析揭示了烟酰胺在宫颈癌进展中的分级特异性积累及其通过SIRT1-CD38-EMT轴调节的治疗潜力 |
Jaiswal, S. |
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N/A |
Metabolomic profiling reveals grade-specific niacinamide accumulation and its therapeutic Potential via SIRT1-CD38-EMT axis modulation in cervical cancer progression |
| WNT7B驱动胰腺癌亚型转换和进展的程序 |
Sprangers, J. |
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N/A |
WNT7B drives a program for pancreatic cancer subtype switching and progression |
| 转移灶对其宿主组织的基因表达适应 |
Nagel, L. |
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N/A |
Gene expression adaptation of metastases to their host tissue |
| BRAF V600和ErbB抑制剂通过非靶向方式直接激活GCN2，从而限制癌细胞的增殖。 |
Ill, C. R. |
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N/A |
BRAF V600 and ErbB inhibitors directly activate GCN2 in an off-target manner to limit cancer cell proliferation |
| 激酶可塑性对凡德他尼的响应增强了对他莫昔芬的敏感性，并揭示了雌激素受体阳性乳腺癌中的联合治疗策略 |
Kakati, R. T. |
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N/A |
Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen and Identifies Co-Treatment Strategies in Estrogen Receptor Positive Breast Cancer |
| 预测由皮质动力学和面部表情引发的压力诱导快感缺乏的未来发展 |
Coley, A. |
PDF |
N/A |
Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression |
| 宿主和狂犬病病毒基因表达受到人脑细胞类型的影响，并揭示了星形胶质细胞中预先存在的促进病毒转录的状态。 |
Feige, L. |
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N/A |
Host and rabies virus gene expression is shaped by human brain cell type and reveals a preexisting pro-viral transcriptional state in astrocytes |
| C1q和免疫球蛋白介导成年大脑中依赖活动的突触丢失。 |
Crowley, G. |
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N/A |
C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain |
| 抑制金属蛋白酶ADAM19作为一种新型延缓衰老策略，通过调节衰老相关分泌表型（SASP）来改善肠道通透性和衰老标志物。 |
Bar, S. |
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N/A |
Inhibition of the metalloprotease ADAM19 as a Novel Senomorphic Strategy to Ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP) |
| 通过综合单细胞组学分析预测人类角膜的细胞状态及关键转录因子 |
Arts, J. A. |
PDF |
N/A |
Prediction of Cell States and Key Transcription Factors of the Human Cornea through Integrated Single-Cell Omics Analyses |
| 野火烟雾和柴油尾气对老化人脑微胶质细胞炎症反应的影响 |
Cuni-Lopez, C. |
PDF |
N/A |
Impact of wildfire smoke and diesel exhaust on inflammatory response in aging human microglia |
| Tonic ERK信号传导调节青春期前大鼠Sertoli细胞的基础乳酸生成。 |
GAUTAM, M. |
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N/A |
Tonic ERK signaling regulate the basal lactate production in prepubertal rat Sertoli cell |
| 异质性局部钙离子动态的独特时空同步解决方案是心脏窦房结产生每个脉冲的基础。 |
Tagirova, S. |
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N/A |
Unique spatiotemporal synchronization solutions of heterogeneous local Ca2+ dynamics underlie the formation of each impulse that emerges from the cardiac sinoatrial node |
| tRNA片段的转录后修饰在动脉粥样硬化中赋予高密度脂蛋白功能性变化 |
Semler, E. M. |
PDF |
N/A |
Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis |
| Wnt/β-Catenin通过调控囊泡分化、梭内纤维核聚集及本体感受神经末梢的形成，协调肌梭的发育。 |
Guo, Q. |
PDF |
N/A |
Wnt/β-Catenin coordinates muscle spindle development by regulating capsule differentiation, intrafusal fiber nuclei aggregation and proprioceptive nerve endings |
| 通过与LINE-1调控元件结合，组蛋白甲基转移酶EHMT2协同抑制全能性相关基因位点的表达。 |
Chatterjee, K. |
PDF |
N/A |
Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 through binding to LINE-1 regulatory elements |
| Janus A基因编码一种polo激酶，该激酶的缺失会导致纤毛虫四膜虫（Tetrahymena）中背腹轴的细胞内同源异形现象。 |
Cole, E. S. |
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N/A |
The Janus A gene encodes a polo-kinase whose loss creates a dorsal/ventral intracellular homeosis in the ciliate, Tetrahymena. |
| 使用TARDIS可以准确且快速地分割显微照片和断层扫描图像中的纤维和膜结构。 |
Kiewisz, R. |
PDF |
N/A |
Accurate and fast segmentation of filaments and membranes in micrographs and tomograms with TARDIS |
| 稀疏多任务组套索算法在全基因组关联研究中的应用 |
Nouira, A. |
PDF |
N/A |
Sparse Multitask group Lasso for Genome-Wide Association Studies |
| MorphoDiff：基于扩散模型的细胞形态绘制 |
Navidi, Z. |
PDF |
N/A |
MorphoDiff: Cellular Morphology Painting with Diffusion Models |
| 阳离子/质子反向转运蛋白中组氨酸分子开关的构象动力学 |
Pecorilla, C. |
PDF |
N/A |
Conformational dynamics of a histidine molecular switch in a cation/proton antiporter |
| 血液中的免疫细胞携带了结直肠癌或炎症性肠病患者体内微生物的低生物量DNA残留。 |
Morsy, Y. |
PDF |
N/A |
Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease |
| PI3Ka的RAS结合域的共价抑制剂可抑制由RAS和HER2驱动的肿瘤生长。 |
Klebba, J. E. |
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N/A |
Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2 |
| CD38双等位基因缺失是多发性骨髓瘤中抗CD38抗体耐药的常见机制。 |
Diamond, B. |
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N/A |
CD38 biallelic loss is a recurrent mechanism of resistance to anti-CD38 antibodies in multiple myeloma. |
| Trastuzumab deruxtecan联合治疗显著增强疗效，并克服KRASG12C突变型非小细胞肺癌对sotorasib的耐药性。 |
Ozakinci, H. |
PDF |
N/A |
Trastuzumab deruxtecan combination strongly enhances responses and overcomes sotorasib resistance in KRASG12C-mutant NSCLC |
| 在放射治疗后针对Bcl-xL的抑制作用减少了H3K27M改变的弥漫中线胶质瘤的临床前模型中的肿瘤发生。 |
Vardon, A. |
PDF |
N/A |
Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma |
| 在皮秒尺度上对CERN-CLEAR-VHEE束的微观结构进行修改，会改变ZFE形态发生，但不会影响过氧化氢的产生。 |
Kacem, H. |
PDF |
N/A |
Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production. |
| 解析前列腺癌进展过程中单细胞异质性和细胞生态系统动力学 |
Zhao, F. |
PDF |
N/A |
Deciphering single-cell heterogeneity and cellular ecosystem dynamics during prostate cancer progression |
| 通过肌肉乙酰胆碱受体结构阐明的自身免疫机制 |
Li, H. |
PDF |
N/A |
Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures |
| 对果蝇血淋巴细菌感染后的蛋白质组学分析更新 |
Rommelaere, S. |
PDF |
N/A |
An updated proteomic analysis of Drosophila hemolymph after bacterial infection |
| 多种产甲烷代谢途径的团簇同位素特征 |
Li, J. |
PDF |
N/A |
The clumped isotope signatures of multiple methanogenesis metabolisms |
| IVISc-L：一种快速简便的体内检测方法，用于研究基因表达的调控 |
Som, S. |
PDF |
N/A |
IVISc-L: A quick and simple in vivo assay to study the regulation of gene expression |
| 整合空间转录组学和单核转录组学以绘制发育中小鼠肾脏的基因表达图谱 |
Chaney, C. |
PDF |
N/A |
Integration of spatial and single nucleus transcriptomics to map gene expression in the developing mouse kidney |
| PRMT5-剪接轴是调控滞留内含子剪接的关键致癌脆弱点。 |
Fowler, C. E. |
PDF |
N/A |
The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing |
| 他汀类药物抑制B7-H3的4Ig异构体的致癌二聚化作用。 |
Sutton, M. N. |
PDF |
N/A |
Statins inhibit onco-dimerization of the 4Ig isoform of B7-H3 |
| 基于硅藻细胞壁的硅藻素驱动遗传工程：对生物硅形态和纳米材料设计的洞察 |
Qiao, T. |
PDF |
N/A |
Silaffins-Driven Genetic Engineering of Diatom Cell Walls: Insight into Biosilica Morphology and Nanomaterial Design |
| 人类树突棘形态与密度的综合分析：探索人类树突棘的多样性 |
Schuenemann, K. D. |
PDF |
N/A |
Comprehensive Analysis of Human Dendritic Spine Morphology and Density: Exploring Diversity of Human Dendritic Spines |
| Munc18-1缺陷型光感受器突触前终末内目标SNARE蛋白的隔离定位 |
Huang, M. |
PDF |
N/A |
Segregated localization of target-SNARE proteins within presynaptic terminals of Munc18-1 deficient photoreceptors |
| 社交互动感知与心理理论的共同和独特神经相关性 |
Miao, Z. |
PDF |
N/A |
Common and distinct neural correlates of social interaction perception and theory of mind |
| 单细胞RNA测序用于鉴定源自诱导多能干细胞（iPSC）衍生的少突胶质细胞谱系培养物中的胶质前体亚群 |
Blaszczyk, G. J. |
PDF |
N/A |
Single Cell RNAseq to identify subpopulations of glial progenitors in iPSC-derived oligodendroglial lineage cultures |
| 前运动皮层血流动力学反映的是内部听觉类别，而非报告的类别。 |
Boucher, J. E. |
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N/A |
Premotor cortex hemodynamics reflect internal auditory category, not reported category |
| 神经双域模型用于髓鞘纤维束沿郎飞结的多维电耦合神经冲动传播的多维电耦合 |
Chun, S. |
PDF |
N/A |
Neural bidomain model for multidimensional ephaptic coupling of neural spike propagation along myelinated fiber bundles with the nodes of Ranvier |
| 野生鼠类中SARS-CoV-2的传染潜力与传播情况 |
Beissat, K. |
PDF |
N/A |
Infectious potential and circulation of SARS-CoV-2 in wild rats |
| 不同的微生物群落导致甲烷排放对氧气变化产生不同的响应，这些变化发生在多样化的湿地土壤中。 |
Reji, L. |
PDF |
N/A |
Distinct Microbiomes Underlie Divergent Responses of Methane Emissions from Diverse Wetland soils to Oxygen Shifts |
| 网格蛋白适配体AP-1在植物病原菌灰葡萄孢（Botrytis cinerea）细胞壁完整性和毒力因子分泌中的作用 |
Calvar, G. |
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N/A |
Role of the clathrin adaptor AP-1 in cell wall integrity and virulence factor secretion in the plant pathogen Botrytis cinerea |
| 来自湿地和堆肥的戈登氏菌（Gordonia sp.）和节杆菌（Arthrobacter sp.）对聚烯烃的定殖及部分降解 |
Coughlin, S. A. |
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N/A |
Polyolefin colonization and partial degradation by Gordonia sp., and Arthrobacter sp. isolated from wetlands and compost |
| 对SARS-CoV-2 nsp16/nsp10介导的2'-O RNA甲基化组装和调控的结构洞察 |
Misra, A. |
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N/A |
Structural Insights into the Assembly and Regulation of 2'-O RNA Methylation by SARS-CoV-2 nsp16/nsp10 |
| 重组Pichinde报告病毒作为针对高致病性沙粒病毒的高通量抗病毒筛选的安全且合适的替代品 |
Sacramento, C. Q. |
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N/A |
Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenaviruses |
| 自体宿主-病原体配对增强了结核病体外肉芽肿模型中的早期免疫反应和细菌生长控制 |
Genestet, C. |
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N/A |
Autologous host-pathogen pairing enhances early immune responses and bacterial growth control in tuberculosis in vitro granuloma model |
| 碱基修饰的核苷酸在细菌中调节免疫信号传导 |
Zeng, Z. |
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N/A |
Base-modified nucleotides mediate immune signaling in bacteria |
| 通过肌动蛋白网络，Exportin XPO1动员核抗病毒因子抑制RNA病毒复制。 |
Sun, B. |
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N/A |
Mobilization of nuclear antiviral factors by Exportin XPO1 via the actin network inhibits RNA virus replication |
| 建立严格依赖病毒蛋白表达的基孔肯雅病毒假型系统 |
Tanaka, A. |
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N/A |
Establishment of a Chikungunya virus pseudotype system strictly dependent on viral protein expression |
| 语言多样性与基因多样性之间存在负相关关系。 |
Graff, A. |
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N/A |
An inverse correlation between linguistic and genetic diversity |
| 全球基因混合模式揭示了语言接触的影响。 |
Graff, A. |
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N/A |
Global patterns of genetic admixture reveal effects of language contact |
| 对狒狒混合种群的负选择在性染色体X上表现得最为强烈。 |
Soerensen, E. F. |
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N/A |
Negative selection on baboon admixture is strongest on chromosome X |
| 综合分析COVID-19多组学数据以发现eQTL，揭示了疾病严重程度的遗传机制 |
Lee, J. |
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N/A |
Integrated analysis of COVID-19 multi-omics data for eQTLs reveals genetic mechanisms underlying disease severity |
| Tiled Amplicon测序技术实现了从临床样本中对病原菌进行无培养的全基因组测序。 |
Kalinich, C. C. |
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N/A |
Tiled Amplicon Sequencing Enables Culture-free Whole-Genome Sequencing of Pathogenic Bacteria From Clinical Specimens |
| 自定义选择性过滤器几何形状的钙通道自下而上设计 |
Liu, Y. |
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N/A |
Bottom-up design of calcium channels from defined selectivity filter geometry |
| 用于成像细胞内和细胞外钾离子的基因编码红色荧光指示剂 |
Yang, L. |
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N/A |
Genetically Encoded Red Fluorescent Indicators for Imaging Intracellular and Extracellular Potassium Ions |
| T-ALPHA：一种基于分层Transformer的深度神经网络，用于蛋白质-配体结合亲和力预测，并结合不确定性感知的自学习方法以实现蛋白质特异性对齐 |
Kyro, G. W. |
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N/A |
T-ALPHA: A Hierarchical Transformer-Based Deep Neural Network for Protein-Ligand Binding Affinity Prediction With Uncertainty-Aware Self-Learning for Protein-Specific Alignment |
| 基于连锁的细菌泛基因组同源基因精炼工具CLARC |
Ojeda, I. G. |
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N/A |
Linkage-based ortholog refinement in bacterial pangenomes with CLARC |
| 草原土壤微生物群的活跃子集会随着土壤深度、水分可用性而变化，并且显著地包括捕食性细菌和兼性共生体。 |
Penev, P. I. |
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N/A |
The active subset of grassland soil microbiomes changes with soil depth, water availability and prominently features predatory bacteria and episymbionts |
| 量化表征和预测针对Omicron变种的广谱中和抗体的结合决定因素及免疫逃逸热点：SARS-CoV-2刺突蛋白与抗体复合物的原子级建模 |
Alshahrani, M. |
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N/A |
Quantitative Characterization and Prediction of the Binding Determinants and Immune Escape Hotspots for Groups of Broadly Neutralizing Antibodies Against Omicron Variants: Atomistic Modeling of the SARS-CoV-2 Spike Complexes with Antibodies |
| 前颞叶神经元通过声音身份不变性实现识别 |
Giamundo, M. |
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N/A |
Voice identity invariance by anterior temporal lobe neurons |
| 功能连接的局部梯度能够在动态发育过程中精确识别婴儿大脑的特征 |
Yuan, X. |
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N/A |
Local Gradients of Functional Connectivity Enable Precise Fingerprinting of Infant Brains During Dynamic Development |
| 糖皮质激素作用于新生少突胶质细胞前体细胞，以调节成年海马网络可塑性和应激诱导行为。 |
Mattioni, L. |
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N/A |
Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior |
| NaV1.2和NaV1.6在皮层锥体细胞兴奋性中的不同作用 |
Garcia, J. D. |
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N/A |
Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability |
| LPS 刺激B细胞代谢的动态变化以促进增殖。 |
Cheung, D. M. S. |
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N/A |
LPS stimulates dynamic changes in B cell metabolism to promote proliferation |
| 皮肤巨噬细胞中的FABP5介导饱和脂肪引发的IL-1β信号传导，促进肥胖相关银屑病的发展。 |
Yu, J. |
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N/A |
FABP5 in Skin Macrophages Mediates Saturated Fat-Induced IL-1β Signaling in Obesity-Associated Psoriasis Development |
| 研究在啮齿动物、非啮齿动物及食蟹猕猴中使用印度尼西亚株病毒的CpG佐剂重组RBD SARS-CoV-2疫苗的免疫原性、功效及安全性 |
Limeilati, N. A. |
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N/A |
Study of the immunogenicity, efficacy and safety of recombinant RBD SARS-CoV-2 vaccine with CpG adjuvant in rodent, non-rodent and Maccaca fascicularis using Indonesian Strain Virus |
| 全球红树林沉积物中细菌的生物地理学：基于16S rDNA元条形码的空间模式与生态见解 |
Jamon-Haon, E. |
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N/A |
Global Biogeography of Prokaryotes in Mangrove Sediments: Spatial Patterns and Ecological Insights from 16S rDNA Metabarcoding |
| 冷冻电镜结构揭示了松弛体（relaxosome）的结构，这一复合物对细菌交配及抗生素抗性基因的传播至关重要。 |
Williams, S. |
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N/A |
Cryo-EM Structure of the relaxosome, a complex essential for bacterial mating and the spread of antibiotic resistance genes |
| 长期护理机构中与养老院获得性肺炎相关的病原体流行率及共存情况 |
Whealy, R. N. |
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N/A |
Longitudinal prevalence and co-carriage of pathogens associated with nursing home acquired pneumonia in three long-term care facilities |
| 保守的全球调节因子H-NS对Vibrio fischeri共生体中的生物膜形成具有菌株特异性的影响。 |
Zarate, D. |
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N/A |
The conserved global regulator H-NS has a strain-specific impact on biofilm formation in Vibrio fischeri symbionts |
| 产后早期母体向婴儿的质粒传递及其与优势肠道细菌的关联 |
Kuriyama, Y. |
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N/A |
Mother-to-infant plasmid transmission in early postpartum and its association with dominant gut bacteria |
| 实时纳米级研究枯草芽孢杆菌孢子衣的组装 |
Lablaine, A. |
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N/A |
Real-Time Nanoscale Investigation of Spore Coat Assembly in Bacillus subtilis |
| 一种传递的脱氧核糖核酸酶毒素通过短暂毒害同胞个体，创造了种群的异质性。 |
Eriksson, H. |
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N/A |
A delivered DNase toxin creates population heterogeneity through transient intoxication of siblings. |
| 雾化的2-脱氧葡萄糖类似物在先进的体外气道模型中抑制呼吸道病毒感染 |
Wideman, S. K. |
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N/A |
Nebulized 2-deoxylated glucose analogues inhibit respiratory viral infection in advanced in vitro airway models |
| 白色念珠菌蛋白质组的综合视图 |
Gomez Artiguez, L. |
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N/A |
Candida albicans a comprehensive view of the proteome |
| 化学降解法鉴定出人p38-MAPK是抗击寄生虫感染的宿主靶点 |
Singhal, J. |
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N/A |
Chemical degradation identified Human p38-MAPK as a host target to combat parasitic infections |
| 肠道菌群介导的芒果苷向诺拉西醇的转化改变了短链脂肪酸和尿酸代谢 |
Bunt, D. |
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N/A |
Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism |
| 酵母CST和Polα/引物酶复合物协同作用，以确保端粒的正确维持和保护。 |
Calugaru, K. |
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N/A |
The yeast CST and Polα/primase complexes act in concert to ensure proper telomere maintenance and protection |
| 一个大型语言模型指导通过组合优化生成的变体抗体的亲和力成熟过程。 |
Ashraf, F. B. |
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N/A |
A Large Language Model Guides the Affinity Maturation of Variant Antibodies Generated by Combinatorial Optimization |
| TEAD促进了腹侧神经祖细胞的谱系进展，与YAP/TAZ无关。 |
Perry, C. H. |
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N/A |
TEAD promotes lineage progression of subpallial neural progenitor cells independent of YAP/TAZ |
| 通过不同的抑制性组蛋白甲基化模式定义了不同的层粘连蛋白相关域类。 |
Martin, C. J. |
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N/A |
Distinct Classes of Lamin-Associated Domains are Defined by Differential Patterns of Repressive Histone Methylation |
| 三维调控枢纽在胶质母细胞瘤中支持致癌程序 |
Breves, S. L. |
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N/A |
Three-dimensional regulatory hubs support oncogenic programs in glioblastoma |
| 沙门氏菌Typhimurium中VI型分泌系统蛋白VgrS的结构 |
Sachar, K. |
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N/A |
Structure of the type VI secretion system protein VgrS from Salmonella Typhimurium |
| 在游离DNA片段组学特征上进行有监督的非负矩阵分解，可增强早期癌症检测 |
Tran, T. H. |
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N/A |
Supervised non-negative matrix factorization on cell-free DNA fragmentomic features enhances early cancer detection |
| 淀粉样蛋白形成的人溶菌酶中间体通过非天然酰胺-π相互作用得到稳定。 |
Ahn, M. |
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N/A |
Amyloid forming human lysozyme intermediates are stabilised by non-native amide-π interactions |
| 水平基因转移和萜类代谢在角苔植物与真菌相互作用中发挥驱动作用 |
El Mahboubi, K. |
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N/A |
Horizontal gene transfers and terpene metabolism drive plant-fungal interaction in Marchantia polymorpha |
| 超潮汐河口鱼类生物多样性监测中eDNA捕获方法的表现 |
Jackman, J. M. |
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N/A |
Performance of eDNA capture methods for monitoring fish biodiversity in a hyper-tidal estuary |
| 驱动蛋白-1具有高度的柔性，在没有货物的情况下会采取开放的构象。 |
Smith, E. R. |
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N/A |
Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo |
| 利用基于诱导多能干细胞（hiPSC）的模型研究BPDE诱导的胚胎毒性 |
Meira de Amorim, V. C. |
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N/A |
Investigating BPDE-induced embryonic toxicity employing hiPSC-based models |
| APOE4改变了脂滴的蛋白质组，并调节了脂滴的动态变化。 |
Friday, C. M. |
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N/A |
APOE4 alters the lipid droplet proteome and modulates droplet dynamics |
| 免疫情绪素在强迫症患者的T细胞和血浆中表现出差异表达。 |
Blacksell, I. A. |
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N/A |
Immuno-moodulin is Differentially Expressed in T Cells and Plasma in Obsessive-Compulsive Disorder Patients |
| IgG的抗炎活性需要I型和II型Fc受体的共同参与。 |
Jones, A. T. |
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N/A |
The anti-inflammatory activity of IgG requires the co-engagement of types I and II Fc receptors |
| 小鼠2型先天淋巴细胞的免疫代谢分析：一种稳健的逐步方法 |
Krisna, S. S. |
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N/A |
Immunometabolic analysis of primary murine Group 2 Innate Lymphoid Cells: a robust step-by-step approach |
| 从头设计和结构化一个以肽为中心的TCR模拟结合模块 |
Householder, K. D. |
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N/A |
De novo design and structure of a peptide-centric TCR mimic binding module |
| 二维类器官展示了寄生线虫及其分泌产物在肠道上皮基底或顶端相互作用的特异性。 |
White, R. |
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N/A |
2-D organoids demonstrate specificity in the interactions of parasitic nematodes and their secreted products at the basal or apical intestinal epithelium |
| 无需生态位指令、反馈或微调的自我更新 |
MacArthur, B. |
PDF |
N/A |
Self-renewal without niche instruction, feedback or fine-tuning |
| 流感病毒A触发的细胞间钙波传播在促进感染中的关键作用 |
Kozawa, F. |
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N/A |
The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection |
| 野鸟，尤其是候鸟，在北美地区密集传播H5N1病毒，导致其迅速地理扩散并反复溢出到农业领域。 |
Damodaran, L. |
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N/A |
Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America |
| 一个用于估计重要农业病害系统中媒介传播和疾病扩散的建模框架 |
Preedy, K. F. |
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N/A |
A modelling framework to estimate vector dispersal and disease spread in an important agricultural pathosystem |
| 空间系统发育学与连续数据：加利福尼亚苔藓植物的应用研究 |
Kling, M. M. |
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N/A |
Spatial Phylogenetics with Continuous Data: an Application to California Bryophytes |
| 基因调控网络推断与联合表示：图神经网络与单细胞基础模型的结合 |
Kommu, S. |
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N/A |
Gene Regulatory Network Inference with Joint Representation from Graph Neural Network and Single-Cell Foundation Model |
| 非洲各地dhfr和dhps基因上磺胺多辛和乙胺嘧啶抗性等位基因和单倍型的不同共进化及流行 |
White, N. F. D. |
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N/A |
Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa |
| 清道夫受体CD163通过多聚化来摄取多种配体。 |
Zhou, R. X. |
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N/A |
Scavenger receptor CD163 multimerises to allow uptake of diverse ligands |
| UBR4复合体的结构，作为真核蛋白质质量控制的核心E4连接酶 |
Grabarczyk, D. B. |
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N/A |
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control |
| 用于三色RNA成像的正交RNA调控降解结构域，具有最小RNA干扰 |
Wu, J. |
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N/A |
Orthogonal RNA-regulated destabilization domains for three-color RNA imaging with minimal RNA perturbation |
| 含焦磷酸盐的磷酸钙对异位骨质量有负面影响 |
Jolic, M. |
PDF |
N/A |
Pyrophosphate-containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality |
| 制剂、表征及体内免疫原性研究：新型VLP疫苗热稳定可溶性微针的研制 |
Muttil, P. |
PDF |
N/A |
Formulation, Characterization, and in vivo Immunogenicity of Heat-Stabilized Dissolvable Microneedles Containing a Novel VLP Vaccine |
| 使水凝胶涂层在硅胶乳房假体上与聚（醋酸乙烯酯）底漆层 |
Stanger, K. |
PDF |
N/A |
Enabling Hydrogel Coating on Silicone Breast Implants with Poly(Vinyl Acetate) Primer Layer |
| 通过MutaT7实现的与生长耦合的连续定向进化，实现了高效且自动化的酶工程。 |
Deng, Y. |
PDF |
N/A |
Growth-coupled continuous directed evolution by MutaT7 enables efficient and automated enzyme engineering |
| 时间参数决定迷走神经刺激引导神经可塑性的效果 |
Addo, J. J. A. |
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N/A |
Temporal Parameters Determine the Efficacy of Vagus Nerve Stimulation Directed Neural Plasticity |
| 揭示潜力：细菌微室壳蛋白的光捕获与半导体特性 |
Bedi, S. |
PDF |
N/A |
Illuminating the Potential: Light Harvesting and Semiconducting Properties of Bacterial Microcompartment Shell Proteins |
| CCGM：一种用于增强化学型探索、注释和筛选的复合粗粒度模型表示法 |
Sahni, N. |
PDF |
N/A |
CCGM: a Compound Coarse Grain Model representation for enhanced chemotype exploration, annotation and screening |
| ScHiCAtt：利用基于注意力模型的方法提升单细胞Hi-C分辨率 |
Menon, R. |
PDF |
N/A |
ScHiCAtt: Enhancing Single-Cell Hi-C Resolution Using Attention-Based Models |
| 捕捉HSPB1分子伴侣寡聚体在原子分辨率下的构象异质性 |
Berkeley, R. F. |
PDF |
N/A |
Capturing the Conformational Heterogeneity of HSPB1 Chaperone Oligomers at Atomic Resolution |
| 细胞间通讯控制了类原肠胚对称性破缺的时机 |
Oriola, D. |
PDF |
N/A |
Cell-cell communication controls the timing of gastruloid symmetry-breaking |
| 一种用于可逆光学控制外周镇痛的阿片类药物疗效转换 |
Posa, L. |
PDF |
N/A |
An opioid efficacy switch for reversible optical control of peripheral analgesia |
| 胚胎暴露于阻燃剂四溴双酚A（TBBPA）会破坏斑马鱼的背腹模式形成。 |
Senarath Pathirajage, K. |
PDF |
N/A |
Embryonic exposures to flame retardant tetrabromobisphenol A (TBBPA) disrupts dorsoventral patterning in zebrafish |
| 通过计算机模拟发现针对MEIG1-PACRG复合物的潜在抑制剂，用于男性避孕药物的开发 |
Hasse, T. A. |
PDF |
N/A |
In silico discovery of potential inhibitors targeting the MEIG1-PACRG complex for male contraceptive development |
| IL-17A 对早期祖细胞群体进行预处理，以调节红细胞生成的反馈回路。 |
Wu, Q. C. |
PDF |
N/A |
IL-17A primes an early progenitor compartment to tune the erythropoietic feedback circuit |
| 融合跨通道和时间的多感官信号 |
Anil, S. |
PDF |
N/A |
Fusing multisensory signals across channels and time |
| 利用人工智能分类和预处理技术，通过直接冷冻电子断层扫描检测天然SNARE和Munc13蛋白桥 |
Orozco-Borunda, D. H. |
PDF |
N/A |
Direct cryo-ET detection of native SNARE and Munc13 protein bridges using AI classification and preprocessing |
| BACH2驱动的组织驻留记忆程序促进HIV-1持久性 |
Wei, Y. |
PDF |
N/A |
BACH2-driven tissue resident memory programs promote HIV-1 persistence |
| 不同脂质体配方的5-氟尿嘧啶会导致胃肠道毒性的变化。 |
Thorpe, D. W. |
PDF |
N/A |
Different liposomal formulations of 5-Fluorouracil result in variations to gastrointestinal toxicities |
| 基于模拟的近亲标记重捕推断：对小规模种群和非随机交配的启示 |
Conn, P. B. |
PDF |
N/A |
Simulation-based inference for close-kin mark-recapture: implications for small populations and nonrandom mating |
| 预测巨藻修复对食物网和渔业生产的影响 |
O'Neill, T. |
PDF |
N/A |
Predicting the impact of giant kelp restoration on food webs and fisheries production |
| 血吸虫杂交种的转录组可塑性可能有助于其人兽共患潜力。 |
Toulza, E. |
PDF |
N/A |
Transcriptomic plasticity in hybrid schistosomes can contribute to their zoonotic potential |
| 分离到一株能够降解截短侧耳素泰妙菌素的鞘氨醇单胞菌新菌株：组学分析揭示其转化途径 |
Perruchon, C. |
PDF |
N/A |
Isolation of a novel Sphingomonas strain able to degrade the pleuromutilin tiamulin: omic analysis reveals its transformation pathway |
| 时间分辨荧光蛋白在时间和光谱域荧光显微镜中的应用 |
Tan, Z. |
PDF |
N/A |
Time-resolved fluorescent proteins towards fluorescence microscopy in the temporal and spectral domains |
| 一个可推广的染色质结构基础模型，适用于跨物种的单细胞和多组学分析 |
Wang, X. |
PDF |
N/A |
A generalizable Hi-C foundation model for chromatin architecture, single-cell and multi-omics analysis across species |
| 蛋白酶体激活剂PA200调控肿瘤细胞侵袭 |
Yazgili, A. S. |
PDF |
N/A |
The proteasome activator PA200 regulates tumor cell invasion |
| GRN建模器：一种直观构建和评估基因调控网络的工具及其在振荡器和光生物传感器中的应用 |
Hollo, G. |
PDF |
N/A |
GRN modeler: An Intuitive Tool for Constructing and Evaluating Gene Regulatory Networks and its Applications to Oscillators and a Light Biosensor |
| 亚基类型、选择性剪接和辅助蛋白对AMPA受体转运的影响 |
Couch, T. |
PDF |
N/A |
The impact of subunit type, alternative splicing, and auxiliary proteins on AMPA receptor trafficking |
| 前额叶伽马振荡和恐惧消退学习需要早期新生期的中间神经元-少突胶质细胞间的交流。 |
Plaisier, F. |
PDF |
N/A |
Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication |
| 转基因线在斑马鱼幼体中标记网状脊髓神经元的特性分析 |
Collins, E. M. |
PDF |
N/A |
Characterisation of transgenic lines labelling reticulospinal neurons in larval zebrafish |
| PPARδ通过限制CIITA-MHC II的表达，抑制了肿瘤内Treg细胞的抑制功能。 |
Yang, Q. |
PDF |
N/A |
PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expression |
| AMPK通过消除免疫屏障，促进CD8+ T细胞介导的针对肝细胞癌的免疫反应。 |
Hu, H.-H. |
PDF |
N/A |
AMPK acts to remove immune barriers to CD8+ T cell-mediated immunity against hepatocellular carcinoma |
| 鉴定调控多形拟杆菌生物膜形成的菌株特异性信号 |
Glowacki, R. W. P. |
PDF |
N/A |
Identification of strain-specific cues that regulate biofilm formation in Bacteroides thetaiotaomicron |
| 一个全面的基准测试，针对具有广泛靶向范围的多款高效基础编辑器 |
Wang, X. |
PDF |
N/A |
A comprehensive benchmark for multiple highly efficient base editors with broad targeting scope |
| 使用RNA-seq研究犬弓蛔虫幼虫在体外暴露于大环内酯类药物后的转录反应 |
Quintana, T. A. |
PDF |
N/A |
Transcriptional responses to in vitro macrocyclic lactone exposure in Toxocara canis larvae using RNA-seq |
| 左右大脑皮层相互作用驱动纤毛虫四膜虫的细胞内模式形成 |
Lee, C. |
PDF |
N/A |
Left-right cortical interactions drive intracellular pattern formation in the ciliate Tetrahymena |
| 特定物种的氧气感应控制着脊椎动物肢体再生的启动 |
Tsissios, G. |
PDF |
N/A |
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration |
| 嗅觉丧失会降低毛虫的性能并增加对天敌的易感性。 |
Wang, Q. |
PDF |
N/A |
Loss of olfaction reduces caterpillar performance and increases susceptibility to a natural enemy |
| 珊瑚Acropora loripes组织内Endozoicomonas的不同聚集模式 |
Gotze, C. R. |
PDF |
N/A |
Differential aggregation patterns of Endozoicomonas within tissues of the coral Acropora loripes |
| 在私人信息和社会信息获取成本下分散策略的演化 |
Sion, A. |
PDF |
N/A |
On the evolution of dispersal strategies under the costs of acquisition of private and social information |
| 利用环境DNA宏基因组学提升整体生物多样性监测与发现 |
Curto, M. A. C. |
PDF |
N/A |
Improving whole biodiversity monitoring and discovery with environmental DNA metagenomics |
| 自然草地的多样性和生产力随着全球变化因素数量的增加而下降。 |
Wang, J. |
PDF |
N/A |
Diversity and productivity of a natural grassland decline with the number of global change factors |
| 活性氧和抗氧化剂在塑造按蚊生命史及寄生虫耐受性中的作用 |
Zeferino, T. G. |
PDF |
N/A |
The role of prooxidants and antioxidants in shaping life-history and parasite tolerance in Anopheles mosquitoes |
| 染色质相关蛋白全基因组共占据的比较图谱 |
White, S. M. |
PDF |
N/A |
Comparative atlas of genome-wide chromatin-associated protein co-occupancy |
| 评估全基因组加倍对蛛形纲动物发育过程中基因表达和调控的影响 |
Aase-Remedios, M. E. |
PDF |
N/A |
Assessing the impact of whole genome duplication on gene expression and regulation during arachnid development |
| 父母的排斥行为与猫头鹰猴的生存能力下降、行为改变以及miRNAs的代际遗传有关。 |
Farinha, J. |
PDF |
N/A |
Parental rejection is associated with intergenerational inheritance of reduced survival, altered behaviours and miRNAs in Owl Monkeys |
| 解码家禽发声 - 自然语言处理与转换模型用于语义和情感分析 |
Manikandan, V. |
PDF |
N/A |
Decoding Poultry Vocalizations - Natural Language Processing and Transformer Models for Semantic and Emotional Analysis |
| 一个用于生成多维3D对象并具有精细控制特征空间的工具箱：Quaddle 2.0 |
Wen, X. |
PDF |
N/A |
A Toolbox for Generating Multidimensional 3-D Objects with Fine-Controlled Feature Space: Quaddle 2.0 |
| 觅食的熊蜂在采花时的个体间差异性 |
Armand, M. |
PDF |
N/A |
Interindividual variability in flower pickiness by foraging bumblebees |
| 同位素标记和数据非依赖性采集作为在Orbitrap Astral质谱仪上进行蛋白质组学分析的互补策略 |
Liu, X. |
PDF |
N/A |
Isobaric Tagging and Data Independent Acquisition as Complementary Strategies for Proteome Profiling on an Orbitrap Astral Mass Spectrometer |
| 小分子激活肿瘤抑制激酶LKB1 |
Kretschmer, L. S. |
PDF |
N/A |
Small molecule activation of the tumor suppressor kinase LKB1 |
| 血清分离的细胞外囊泡对聚焦超声血脑屏障开放的响应 |
Kline-Schoder, A. R. |
PDF |
N/A |
Response of Serum-isolated Extracellular Vesicles to Focused Ultrasound Blood-Brain Barrier Opening |
| 脂质纳米颗粒条形码技术用于多重单细胞RNA测序 |
Feng, Y. |
PDF |
N/A |
Lipid Nanoparticle Barcoding for Multiplexed Single-Cell RNA Sequencing |
| OPUS-GO：一种基于生物语言模型的可解释蛋白质/RNA序列注释框架 |
Xu, G. |
PDF |
N/A |
OPUS-GO: An interpretable protein/RNA sequence annotation framework based on biological language model |
| 通过样本特异性建模误差率实现低频体细胞突变的精确识别 |
Lin, Y. |
PDF |
N/A |
Accurate calling of low-frequency somatic mutations by sample-specific modeling of error rates |
| 使用下一代蛋白质测序（NGPS）检测氨基酸变异 |
Chinnaraj, M. |
PDF |
N/A |
Detecting Amino Acid Variants Using Next-Generation Protein Sequencing (NGPS) |
| 一个通用且多功能的框架，用于训练和评估自编码器，应用于生物表示学习及其他领域：AUTOENCODIX |
Joas, M. |
PDF |
N/A |
A generalized and versatile framework to train and evaluate autoencoders for biological representation learning and beyond: AUTOENCODIX |
| 基于通路富集的无监督学习方法在胰腺导管癌中识别出癌症相关成纤维细胞的新亚型 |
Ai, H. |
PDF |
N/A |
Pathway enrichment-based unsupervised learning identifies novel subtypes of cancer-associated fibroblasts in pancreatic ductal carcinoma |
| 基于优化的健康饮食建议 |
Wang, X.-W. |
PDF |
N/A |
Optimization-based dietary recommendations for healthy eating |
| 健身转移：通过基于生物学的数据增强提高变异效应预测 |
Mialland, A. |
PDF |
N/A |
Fitness translocation: improving variant effect prediction with biologically-grounded data augmentation |
| HAIRpred：从抗原一级结构预测与人类抗体相互作用残基 |
Sahni, R. |
PDF |
N/A |
HAIRpred: Prediction of human antibody interacting residues in an antigen from its primary structure |
| 使用深度卷积神经网络预测基因表达及DNA结合位点的定位 |
Karshenas, A. |
PDF |
N/A |
Predictive Modeling of Gene Expression and Localization of DNA Binding Site Using Deep Convolutional Neural Networks |
| 体外口腔内含片的崩解 |
Pham, Q. D. |
PDF |
N/A |
In vitro disintegration of lozenge in oral cavity |
| 通过随机物理模型和机器学习来表征活体成像中的粒子动力学 |
Nardi, G. |
PDF |
N/A |
Characterizing particle dynamics in live imaging through stochastic physical models and machine learning |
| 细胞命运决策模型的全局稳定性与临界点预测 |
Xu, L. |
PDF |
N/A |
Global Stability and Tipping Point Prediction of the cell fate decision making model |
| 与癌症相关的ERBB4突变具有转化能力，并使肿瘤对靶向治疗产生耐药性。 |
Ojala, V. K. |
PDF |
N/A |
Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies |
| 伯基特淋巴瘤中的应激诱导信号通路在生发中心来源的B淋巴瘤的命运决定和发病机制中发挥了新型机制的作用。 |
Gothwal, S. K. |
PDF |
N/A |
Stress Induced Signaling Pathways in Burkitt Lymphoma Play Novel Mechanisms in Fate Determination and Pathogenesis of Germinal Center-Derived B-Lymphomas |
| 维京地区的杂草：在冻原草地中干扰优势禾草对杂草繁殖的影响。 |
Celis, G. |
PDF |
N/A |
Forbs in Viking lands: The effect of disturbing dominant graminoids on forb recruitment in tundra grasslands. |
| 莲属日本种VIH2是一种肌醇焦磷酸合酶，能够调控丛枝菌根。 |
Raj, K. |
PDF |
N/A |
Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza |
| FvM4K1是一种丝氨酸/苏氨酸激酶，也是Ste20同源物，通过Hippo信号通路正向调控林地草莓（Fragaria vesca）的果实大小。 |
Qi, B. |
PDF |
N/A |
FvM4K1, a Serine/Threonine Kinase and Ste20 Homolog Positively Regulates Fruit Size via Hippo Signalling Pathway in Woodland Strawberry (Fragaria vesca) |
| 拟南芥RMR蛋白的RING指结构域作为E3连接酶，在反式高尔基体运输过程中起着至关重要的作用。 |
Chen, S. |
PDF |
N/A |
The RING-finger domain of Arabidopsis RMR functions as an E3 ligase essential for post-Golgi trafficking |
| 间作对欧洲大豆和玉米自给自足具有高潜力贡献 |
Chen, M. |
PDF |
N/A |
High potential contribution of intercropping to soybean and maize self-sufficiency in Europe |
| 调控逻辑类别的选择会调节随机布尔网络中的动力学状态 |
Sil, P. |
PDF |
N/A |
Choices of regulatory logic class modulate the dynamical regime in random Boolean networks |
| 视网膜药物输送的数学模型 |
Roberts, P. A. |
PDF |
N/A |
Mathematical Models of Retinal Drug Delivery |
| DeepMapper：基于注意力机制的自编码器用于伤口愈合中的系统识别与阶段预测 |
Lu, F. |
PDF |
N/A |
DeepMapper: Attention-Based AutoEncoder for System Identification in Wound Healing and Stage Prediction |
| 任务和行为相关变量在非空间联想学习过程中由后鼻皮层和内侧内嗅皮层编码 |
Nystuen, I. N. |
PDF |
N/A |
Task and Behavior-Related Variables Are Encoded by the Postrhinal and Medial Entorhinal Cortex During Non-Spatial Associative Learning |
| 使用catFISH技术捕捉对社会等级中主导和从属成员的动态神经元反应 |
Dwortz, M. F. |
PDF |
N/A |
Capturing Dynamic Neuronal Responses to Dominant and Subordinate Social Hierarchy Members with catFISH |
| 轴-轴突抑制理论 |
Brette, R. |
PDF |
N/A |
Theory of axo-axonic inhibition |
| 关键时期支持皮质处理模型中的表征学习。 |
Wu, Z. |
PDF |
N/A |
Critical periods support representation learning in a model of cortical processing |
| 在手部伸向目标时，未能完全适应表面运动 |
Balestrucci, P. |
PDF |
N/A |
Incomplete adaptation to surface movement during hand reaching |
| 小脑类器官在人类小脑发育过程中模拟细胞类型特异性的FOXP2表达 |
Apsley, E. J. |
PDF |
N/A |
Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development |
| 人工具身电路揭示脊椎动物视动行为中的神经结构 |
Liu, X. |
PDF |
N/A |
Artificial Embodied Circuits Uncover Neural Architectures of Vertebrate Visuomotor Behaviors |
| 在轻度围产期缺氧-缺血后数周内持续损失可存活神经元 |
McNally, M. |
PDF |
N/A |
Ongoing loss of viable neurons for weeks after mild perinatal hypoxia-ischemia |
| 一种用于经颅电流传导的无引导场优化框架 |
Weise, K. |
PDF |
N/A |
A Leadfield-Free Optimization Framework for Transcranially Applied Electric Currents |
| 一种基于FRET的FLIM方法用于研究膜诱导的神经元中α-突触核蛋白聚集 |
Ivey, P. M. E. |
PDF |
N/A |
A FRET-Based FLIM Method to Probe Membrane-Induced Alpha-Synuclein Aggregation in Neurons |
| 小鼠耳蜗外毛细胞在机械转导受损情况下的紧张性声音诱发运动 |
Dewey, J. B. |
PDF |
N/A |
Tonic sound-evoked motility of cochlear outer hair cells in mice with impaired mechanotransduction |
| 时间掩蔽信号和空间掩蔽信号在感知连续视觉事件中的贡献 |
Buonocore, A. |
PDF |
N/A |
Contributions of temporal and spatial masking signals in perception of sequential visual events |
| 通过可塑性实现稳定性：通过表征漂移寻找稳定的记忆 |
Natrajan, M. |
PDF |
N/A |
Stability through plasticity: Finding robust memories through representational drift |
| 月经周期中皮质和视网膜血流的内分泌调节 |
Wright, M. E. |
PDF |
N/A |
Endocrine modulation of cortical and retinal blood flow across the menstrual cycle |
| 通过单细胞转录组研究的元分析揭示帕金森病中的性别差异 |
Gordillo-Gonzalez, F. |
PDF |
N/A |
Uncovering sex differences in Parkinson's Disease through metaanalysis of single cell transcriptomic studies |
| Neddylation调控兴奋性神经元的发育与功能 |
Torres, J. |
PDF |
N/A |
Neddylation regulates the development and function of excitatory neurons |
| 在癫痫发生过程中对TrkB-FL受体裂解的研究：来自海人酸诱导的癫痫模型及人类样本的见解 |
Ribeiro-Rodrigues, L. |
PDF |
N/A |
Cleavage of the TrkB-FL Receptor During Epileptogenesis: Insights from a Kainic Acid-Induced Model of Epilepsy and Human Samples |
| 识别调控疼痛引发睡眠障碍的大脑回路 |
Lynch, N. |
PDF |
N/A |
Identifying the Brain Circuits that Regulate Pain-Induced Sleep Disturbances |
| 斑马鱼功能性脑网络的结构和遗传决定因素 |
Legare, A. |
PDF |
N/A |
Structural and genetic determinants of zebrafish functional brain networks |
| 使用MEG测量颜色表征的时间演变揭示了“从粗略到精细”的动态过程。 |
Goddard, E. |
PDF |
N/A |
Temporal evolution of color representations measured with MEG reveals a 'coarse to fine' dynamic |
| 在听力阈值正常的年轻成人中，听觉脑干反应、认知能力与噪音中语音感知之间的关系 |
DiNino, M. |
PDF |
N/A |
The relationship between auditory brainstem responses, cognitive ability, and speech-in-noise perception among young adults with normal hearing thresholds |
| 即用型MHC-I纳米颗粒，用于高通量T细胞筛选研究 |
Phan, H. A. T. |
PDF |
N/A |
Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies |
| 对接受生育治疗的女性卵泡液中的小细胞外囊泡进行单颗粒分析，揭示了独特的PD-L1+群体 |
Bortot, B. |
PDF |
N/A |
Single-particle analysis of small extracellular vesicles from the follicular fluid of women undergoing fertility treatments reveals distinct PD-L1+ populations |
| 有袋类动物的肢体模式重塑了侧板中胚层细分对于肢体形成的必要性。 |
Newton, A. H. |
PDF |
N/A |
Marsupial limb patterning redefines the necessity of lateral plate mesoderm subdivision for limb formation |
| Cxcl12a信号的局部激活调控斑马鱼胚胎中嗅基板的形态发生 |
Zilliox, M. |
PDF |
N/A |
Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos |
| Kcnb1-Kcng4轴调控Scospondin分泌及Reissner纤维的发育 |
Amini, R. |
PDF |
N/A |
Kcnb1-Kcng4 axis regulates Scospondin secretion and Reissner fiber development |
| 沉默的储主正在塑造疾病的出现：荷兰乌苏图病毒的案例 |
de Wit, M. M. |
PDF |
N/A |
Silent reservoirs are shaping disease emergence: the case of Usutu virus in the Netherlands |
| 全球珊瑚礁生态系统的稳定性与临界点预测 |
Xu, L. |
PDF |
N/A |
Global Stability and Tipping Point Prediction of the Coral Reef Ecosystem |
| 两种地理上共存的真菌种植蚂蚁的饲料偏好：一种饮食DNA方法 |
Richards-Perhatch, M. |
PDF |
N/A |
Forage preference in two geographically co-occurring fungus gardening ants: a dietary DNA approach |
| 失传126年：土著知识与相机陷阱记录下极度濒危的黑枕雉鸽（Otidiphaps insularis） |
Gregg, J. J. |
PDF |
N/A |
Lost to science for 126 years: Indigenous Knowledge and Camera Trapping Document the Critically Endangered Black-Naped Pheasant-Pigeon Otidiphaps insularis |
| 净化选择塑造了P因子在果蝇群体中入侵的动态 |
Langmüller, A. M. |
PDF |
N/A |
Purifying Selection Shapes the Dynamics of P-element Invasion in Drosophila Populations |
| 基因组基础模型：预训练并不保证性能 |
Vishniakov, K. |
PDF |
N/A |
Genomic Foundationless Models: Pretraining Does Not Promise Performance |
| 雄激素刺激迅速重塑了前列腺癌中时间性的3D基因组和表观基因组状态，以触发AR介导的转录。 |
Campbell, E. M. |
PDF |
N/A |
Androgen stimulation rapidly reorganizes temporal 3D genome and epigenome states to trigger AR-mediated transcription in prostate cancer. |
| 染色质可及性分类揭示了TAD边界的新型结构蛋白 |
Jacome-Lopez, K. |
PDF |
N/A |
Chromatin accessibility classification of TAD boundaries discloses new architectural proteins |
| 通过表观基因组和转录分析揭示的独特黑质和皮层通路：在罗藤酮诱导的帕金森病大鼠模型中的研究 |
Tsalenchuk, M. |
PDF |
N/A |
Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in a rotenone rat model of Parkinson's disease |
| 脱氨酶介导的染色质可及性分析，具有单等位基因分辨率 |
Yu, T. |
PDF |
N/A |
Deaminase-mediated chromatin accessibility profiling with single-allele resolution |
| HieVi：基于蛋白质组学的噬菌体聚类的蛋白质大型语言模型 |
Panigrahi, S. |
PDF |
N/A |
HieVi: Protein Large Language Model for proteome-based phage clustering |
| 基于MHC-IIB差异的性别特异性择偶和配偶更换在一种遗传上实行一夫一妻制的海鸟中 |
Thel, L. |
PDF |
N/A |
Sex-specific mate choice and mate change based on MHC-IIB dissimilarity in a genetically monogamous seabird |
| 用于伤口愈合的无线生物电子设备 |
Baniya, P. |
PDF |
N/A |
Wireless bioelectronic device for wound healing |
| Venomics AI：利用计算方法探索全球毒液以发现抗生素 |
Guan, C. |
PDF |
N/A |
Venomics AI: a computational exploration of global venoms for antibiotic discovery |
| 均匀原位交联水凝胶包裹高密度人癌细胞促进体内血管化肿瘤模型构建，用于免疫细胞治疗 |
Huang, Z. |
PDF |
N/A |
Homogeneously crosslinked in situ hydrogel enclosing high-density human-cancer cells promotes vascularized in vivo tumor modeling for immune cell therapy |
| 衰老过程中肌腱内葡萄糖和谷氨酰胺代谢的协调性丧失 |
Mlawer, S. J. |
PDF |
N/A |
Coordination of Glucose and Glutamine Metabolism in Tendon is Lost in Aging |
| 一个低成本的无标记运动捕捉系统，用于自动化功能性步态评估：可行性研究 |
Darici, O. |
PDF |
N/A |
A Low-Cost Markerless motion capture system to automate Functional Gait Assessment: Feasibility Study |
| 一种用于预测蛋白质内在无序区域相互作用的深度学习方法 |
Majila, K. |
PDF |
N/A |
A deep learning method for predicting interactions for intrinsically disordered regions of proteins |
| 分类领域，基准测试GPT-4，葡萄牙语医疗AI问答数据集 |
Matsuoka, F. A. |
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N/A |
Classifying Domains, Benchmarking GPT-4, A Portuguese Dataset for Medical AI Q&A |
| 基于进化信息的3D基序预测框架下的全合一RNA折叠 |
Karan, A. |
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N/A |
All-at-once RNA folding with 3D motif prediction framed by evolutionary information |
| 零样本保留时间预测：利用分子结构编码对未见过的翻译后修饰进行预测 |
Dens, C. |
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N/A |
Zero-shot retention time prediction for unseen post-translational modifications with molecular structure encodings |
| 超快冷冻电子显微镜（cryo-UEM）中软物质的辐射损伤行为 |
Zhao, Y. |
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N/A |
Radiation damage behavior of soft matter in ultrafast cryo-electron microscopy (cryo-UEM) |
| 利用新型转录组化学图谱个性化选择化疗药物 |
Lin-Rahardja, K. |
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N/A |
Personalizing chemotherapy drug selection using a novel transcriptomic chemogram |
| 通过核磁共振（NMR）测定的高分子量透明质酸的分子灵活性对癌细胞的侵袭具有深远的影响。 |
Bashtanova, U. |
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N/A |
Molecular flexibility of high molecular weight hyaluronic acid measured by NMR has a profound effect on invasion of cancer cells |
| 氘强化多不饱和脂肪酸可保护小鼠免受1型糖尿病引起的肌肉萎缩。 |
Eshima, H. |
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N/A |
Deuterium-reinforced polyunsaturated fatty acids protect against muscle atrophy induced by type 1 diabetes in mice |
| 参与秀丽隐杆线虫有害光感觉的神经元和分子 |
Dunkel, E. |
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N/A |
Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans |
| 直立姿势在不同姿态下都接近临界稳定性进行控制 |
Geng, Y. |
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N/A |
Upright stance is controlled close to critical stability across different postures |
| 精密抓握研究是否延伸至无约束、多指抓握？ |
Lepori, F. |
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N/A |
Does Precision Grip Research Extend to Unconstrained, Multidigit Grasping? |
| 通过结合神经表示法将项目与情境绑定，使用位置记忆法 |
Huang, J. |
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N/A |
Binding items to contexts through conjunctive neural representations with the Method of Loci |
| MNK1和MNK2在社会和认知行为中发挥着独特的作用，这通过激酶特异性调节突触蛋白质组和磷酸蛋白质组来实现。 |
Proce, R. O. |
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N/A |
Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome |
| 异常的神经元同步与啮齿动物模型中儿童颅部放射治疗引起的认知缺陷相关 |
Barrientos, S. A. |
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N/A |
Aberrant Neuronal Synchronization Associated with Cognitive Deficits in a Rodent Model of Childhood Cranial Irradiation |
| 人类皮肤中睡眠状态伤害感受器的分子结构 |
Koerner, J. |
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N/A |
Molecular architecture of human dermal sleeping nociceptors |
| 石墨烯神经探针揭示了与同步状态相关的大规模细胞外电位的超慢动态 |
Garcia-Cortadella, R. |
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N/A |
Large-scale infra-slow dynamics of extracellular potentials linked to synchronous states revealed by graphene neural probes |
| 瞬时感受器电位香草酸受体通道2（Transient receptor potential vanilloid channel 2）参与了多模式的细胞内质网和核周空间的扩张，这种扩张现象同样可以在朊病毒感染的小鼠中观察到。 |
Zhao, W. |
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N/A |
Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice |
| 使用信息解码技术在皮层中表征色调和饱和度的特征 |
Rozman, A. |
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N/A |
CHARACTERISING REPRESENTATIONS OF HUE AND SATURATION IN THE CORTEX USING INFORMATION DECODING |
| 频率标记的fMRI：一种用于精细时空分析皮层功能的平台 |
Ngo, G. N. |
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N/A |
Frequency-tagged fMRI: A platform for fine-grained spatiotemporal analysis of cortical function |
| 使用可解释的机器学习方法可视化功能性网络连接差异 |
Sendi, M. S. E. |
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N/A |
Visualizing Functional Network Connectivity Differences Using an Explainable Machine-learning Method |
| 中高剂量DMT的时间分辨神经和体验动力学 |
Lewis-Healey, E. |
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N/A |
Time-resolved neural and experience dynamics of medium- and high-dose DMT |
| 朝向实现和解释掩蔽独立成分分析，以识别静息状态下BOLD fMRI脑干中的自主激活特征 |
Miedema, M. E. |
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N/A |
Towards the implementation and interpretation of masked ICA for identifying signatures of autonomic activation in the brainstem with resting-state BOLD fMRI |
| 觉醒过程中慢波活动的电路级动力学及其传播 |
Pazienti, A. |
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N/A |
Circuit-Level Dynamics of Slow Wave Activity and Propagation During the Awakening Process |
| 单次剂量后数周，迷幻药增强灵活学习能力 |
Brouns, E. J. |
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N/A |
Psychedelic enhancement of flexible learning weeks after a single dose |
| 在力场运动学习中，陈述性记忆对快速和慢速适应过程的在线干扰 |
Rudolph, J. L. |
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N/A |
Online interference of declarative memory on fast and slow adaptive processes in force field motor learning |
| 神经元脂肪酸氧化在强化学习后为记忆提供能量 |
Pavlowsky, A. |
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N/A |
Neuronal fatty acid oxidation fuels memory after intensive learning |
| 细胞类型转录特征在体外培养的人脑组织中得以维持。 |
McGinnis, J. |
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N/A |
Cell type transcriptional identities are maintained in cultured ex vivo human brain tissue |
| 小鼠初级视皮层中能量高效编码的时间动态 |
Moosavi, S. A. |
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N/A |
Temporal dynamics of energy-efficient coding in mouse primary visual cortex |
| 重组B3型肠道病毒D68株系能够在293T细胞中高效复制，并感染人脊髓类器官。 |
Jones, J. E. |
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N/A |
Recombinant B3 clade enterovirus D68 strains are efficiently rescued in 293T cells and infect human spinal cord organoids. |
| 输卵管上皮单细胞转录组模型的构建揭示了细胞特化、新的分化轨迹以及与异位妊娠相关的基因网络关联 |
Wright, L. I. |
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N/A |
Single Cell Transcriptomic Modelling of the Fallopian Tube Epithelium Identifies Cellular Specialisation, Novel Differentiation Trajectories, and Gene Network Associations with Ectopic Pregnancy |
| 大象数量增加对树木异速生长的影响 |
Thel, L. |
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N/A |
The effect of an increasing elephant population on the allometry of trees |
| 利用温度依赖型物候模型，为寄生蜂Dolichogenidea gelechiidivoris (Marsh) 进行Tuta absoluta (Meyrick) 的生物防治，绘制适宜释放区域图。 |
Mujica, N. C. |
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N/A |
Mapping of suitable release areas for the parasitoid Dolichogenidea gelechiidivoris (Marsh) for the classical biocontrol of Tuta absoluta (Meyrick) using temperature-dependent phenology models |
| 基因年龄塑造了果蝇精液蛋白质组的功能和进化特性。 |
Ranz, J. M. |
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N/A |
Gene age shapes functional and evolutionary properties of the Drosophila seminal fluid proteome |
| 结构酶学、系统发育学、分化作用与生物学初期的符号反思 |
carter, c. W. |
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N/A |
Structural Enzymology, Phylogenetics, Differentiation, and Symbolic Reflexivity at the Dawn of Biology |
| 城市化对昼夜活动的时间和变异性的影响因雀形目鸟类物种和季节而异。 |
Capilla-Lasheras, P. |
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N/A |
Urban effects on timing and variability of diel activity differ across passerine species and seasons |
| 基于机器学习和实验验证，识别与支链氨基酸相关基因的HIRI潜在特征基因和免疫细胞浸润 |
Zhao, J. |
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N/A |
ldentify potential feature genes and immune cell infiltration of HIRI based on branched-chain amino acid-related genes by machine learning and experimental validation |
| mitoXplorer 3.0，一个用于探索单细胞RNA测序数据中线粒体动态的网络工具。 |
Haering, M. |
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N/A |
mitoXplorer 3.0, a web tool for exploring mitochondrial dynamics in single-cell RNA-seq data. |
| 空间-DC：一种基于深度学习的稳健方法，用于空间蛋白质组学的反卷积 |
Yao, J. |
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N/A |
Spatial-DC: a robust deep learning-based method for deconvolution of spatial proteomics |
| 一个用于自主AI驱动药物发现的框架 |
Selinger, D. W. |
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N/A |
A Framework for Autonomous AI-Driven Drug Discovery |
| 心脏起搏细胞利用随机共振确保在接近窦性停搏的低速率下实现故障安全操作 |
Okamura, A. |
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N/A |
Cardiac Pacemaker Cells Harness Stochastic Resonance to Ensure Fail-Safe Operation at Low Rates Bordering on Sinus Arrest |
| 心脏场特异性心肌细胞分化的分子机制——一种计算建模方法 |
Argyris, G. |
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N/A |
Molecular mechanisms of heart field specific cardiomyoscytedifferentiation- a computational modeling approach |
| 在LRRK2突变但无路易体的情况下，存在丰富的非包含α-突触核蛋白病理。 |
Jensen, N. M. |
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N/A |
Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases |
| α-突触核蛋白寡聚体在LRRK2相关帕金森病中的广泛分布 |
Sekiya, H. |
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N/A |
Widespread Distribution of α-Synuclein Oligomers in LRRK2-related Parkinson's Disease |
| 出生日期使前庭感觉神经元与传感器运动反射回路中的中枢和运动伙伴对齐，以实现注视稳定。 |
Huang, S. |
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N/A |
Birthdate aligns vestibular sensory neurons with central and motor partners across a sensorimotor reflex circuit for gaze stabilization |
| 产后感觉体验与桶状皮质改变预示着Cdkl5缺乏症小鼠模型中的自闭症特征 |
Raspanti, A. |
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N/A |
Postnatal Sensory Experience and Barrel Cortex Alterations Anticipate Autistic Traits in a Mouse Model of Cdkl5 Deficiency Disorder |
| 一种用于功能定向多部位和多尺度研究的混合微型ECoG |
Jendritza, P. |
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N/A |
A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation |
| 基于fMRI定义的非运动皮层目标的TMS诱发电位的重测信度 |
Sayali, C. |
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N/A |
Test-retest reliability of TMS-evoked potentials over fMRI-based definitions of non-motor cortical targets |
| 皮层连接性、局部动态和稳定性与全球意识状态的相关性 |
Zhao, Y. |
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N/A |
Cortical connectivity, local dynamics and stability correlates of global conscious states |
| 人类主体对虚拟环境中空间导航和知识获取的影响 |
Sanchez-Pacheco, T. |
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N/A |
The impact of human agents on spatial navigation and knowledge acquisition in a Virtual Environment |
| 在小鼠中，父母一方的犬尿氨酸3-单加氧酶基因型决定了子代性别特异性的行为结果。 |
Milosavljevic, S. |
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N/A |
Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring |
| HIV-SEQ揭示了来自病毒血症和HIV抑制个体的HIV转录细胞之间的全球宿主基因表达差异 |
Frouard, J. |
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N/A |
HIV-SEQ REVEALS GLOBAL HOST GENE EXPRESSION DIFFERENCES BETWEEN HIV-TRANSCRIBING CELLS FROM VIREMIC AND SUPPRESSED PEOPLE WITH HIV |
| 野生咖啡（Baracoffea）物种中的建筑奇异性：综合形态学视角下的气候适应性咖啡栽培 |
Bezandry, R. |
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N/A |
Architectural singularities in wild Coffea (Baracoffea) species: integrated morphological perspectives for climate-resilient coffee cultivation |
| 埃及伊蚊和白纹伊蚊对塞浦路斯的入侵：当前状况、风险建模及对更广泛的东地中海地区公共卫生的影响。 |
Caminade, C. |
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N/A |
The invasions of Aedes aegypti and Aedes albopictus in Cyprus: current situation, risk modelling and public health implications for the wider Eastern Mediterranean region. |
| 啄还是不啄：早期社会环境对日本鹌鹑反应抑制和冲动攻击性的影响 |
Vernouillet, A. |
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N/A |
To Peck or Not To Peck: The influence of early-life social environment on response inhibition and impulsive aggression in Japanese quails |
| 在蝴蝶中，雌性嗅觉敏感性与雄性求偶行为在时间上是不同步的。 |
Murphy, M. J. |
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N/A |
Female Olfactory Sensitivity is Temporally Asynchronous with Male Courtship in a Butterfly |
| AlphaFold对粘附家族G蛋白偶联受体（aGPCR）结构的预测与分析。 |
Zhou, X. W. |
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N/A |
AlphaFold prediction and analysis of Adhesion-family G protein coupled receptor (aGPCR) structures. |
| Cluefish：通过聚合生物先验知识增强的超富集分析，挖掘转录数据系列的暗物质 |
Franklin, E. |
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N/A |
Cluefish: mining the dark matter of transcriptional data series with over-representation analysis enhanced by aggregated biological prior knowledge |
| 线粒体ACSS1在营养匮乏条件下调控淋巴瘤中的致癌代谢物2-羟基戊二酸和从头合成嘧啶 |
Basappa, J. |
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N/A |
Mitochondrial ACSS1 regulates the oncometabolite 2-hydroxyglutarate and De Novo Pyrimidine biosynthesis under nutrient-deprived conditions in lymphoma |
| 内皮剥离法在芯片上实现的内向性血管生成：跨管腔血管桥接的证据 |
Staples, S. C. R. |
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N/A |
Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination |
| 接触新的雌性会提高成年雄性草原田鼠的繁殖力。 |
Hurd, J. |
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N/A |
Exposure to novel females increases fecundity in adult male prairie voles |
| 在诱导型启动子和普遍染色质开放元件（UCOE）之间的终止序列可以减少基因表达的泄漏和沉默。 |
Yanagi, T. |
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N/A |
Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing |
| 刺激参数塑造有效连接路径：微状态分析对TMS诱发电位的洞察 |
Lucarelli, D. |
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N/A |
Stimulation parameters shape effective connectivity pathways: insights from microstate analysis on TMS-evoked potentials |
| 食物对昼夜节律时间调节的调控作用位于背侧迷走神经复合体 |
Chrobok, L. |
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N/A |
Food-entrainment of circadian timekeeping in the dorsal vagal complex |
| 成年小鼠的膳食铁缺乏会增加大脑内皮细胞对高亲和力抗转铁蛋白受体抗体的摄取和血脑屏障的运输。 |
Kostrikov, S. |
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N/A |
Dietary iron deficiency in the adult mouse increases brain endothelial uptake and blood-brain barrier transport of a high-affinity, anti-transferrin receptor antibody |
| 源到传感器的耦合（Source to sensor coupling, SoSeC）作为一种有效的工具，用于从EEG和MEG数据中定位相互作用的源。 |
Goeschl, F. |
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N/A |
Source to sensor coupling (SoSeC) as an effective tool to localize interacting sources from EEG and MEG data |
| 通过微流控流动池技术在人中性粒细胞中鉴定的羟基羧酸3受体的激活和信号传导特性 |
Forsman, H. |
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N/A |
Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique |
| 根据韩国商业猪的血液学和免疫学参数建立特定年龄的区间 |
Song, D. |
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N/A |
Establishment of age-specific intervals based on the hematological and immunological parameters of commercial pigs in the Republic of Korea |
| 用于检测细菌中噬菌体抗性CBASS机制的LAMP-CRISPR-Cas13a技术 |
Ortiz-Cartagena, C. |
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N/A |
The LAMP-CRISPR-Cas13a technique for detecting CBASS-mechanism of phage resistance in bacteria |
| 硅-罗丹明辅助的识别（SeeID）技术用于近红外光控制的体外和体内邻近标记 |
Wang, W. |
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N/A |
Silicon-rhodamine-enabled Identification (SeeID) for Near-Infrared Light Controlled Proximity Labeling In Vitro and In Vivo |
| 一个位点控制区域在足月胎盘中生成不同的活性胎盘催乳素和非活性生长激素基因域，这些基因域在肥胖情况下会被破坏。 |
Jin, Y. |
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N/A |
A Locus Control Region Generates Distinct Active Placental Lactogen And Inactive Growth Hormone Gene Domains In Term Placenta That Are Disrupted With Obesity |
| 全基因组评估遗传拯救：一个奇特孤立且濒危蝴蝶的案例 |
MacDonald, Z. G. |
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N/A |
Whole-genome evaluation of genetic rescue: the case of a curiously isolated and endangered butterfly |
| 尽管有易感宿主的调控，蜗牛间的种内捕食现象仍推动了人类血吸虫的增殖。 |
Shaw, K. E. |
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N/A |
Intraguild predation among snails drives human schistosome amplification despite susceptible host regulation |
| TFClassPredict：一种利用进化上保守的DNA结合域注释进行转录因子结合位点分析的新型深度学习框架 |
Timucin, C. H. |
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N/A |
TFClassPredict: A Novel Deep Learning Framework for Transcription Factor Binding Site Analysis Using Evolutionarily Conserved DNA-Binding Domain Annotations |
| 靶向横纹肌肉瘤中的从头胆固醇合成会导致细胞周期阻滞，并通过内质网应激介导的途径触发细胞凋亡。 |
Gizaw, N. Y. |
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N/A |
Targeting de novo cholesterol synthesis in rhabdomyosarcoma induces cell cycle arrest and triggers apoptosis through ER stress-mediated pathways |
| 发育中和成年人类大脑中肌营养不良蛋白异构体表达的综合时空图谱 |
Catapano, F. |
PDF |
N/A |
A comprehensive spatiotemporal map of dystrophin isoform expression in the developing and adult human brain |
| 用于分析基因-环境相互作用的通路多基因风险评分（pPRS） |
Gauderman, W. J. |
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N/A |
Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction |
| 工程化水凝胶生物材料促进从诱导多能干细胞分化为肺祖细胞 |
Tanneberger, A. E. |
PDF |
N/A |
Engineered hydrogel biomaterials facilitate lung progenitor cell differentiation from induced pluripotent stem cells |
| 细胞记忆：利用瓶颈式Transformer对分布外细胞进行分层解释 |
Wang, Q. |
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N/A |
CellMemory: Hierarchical Interpretation of Out-of-Distribution Cells Using Bottlenecked Transformer |
| 噬菌体T7激酶的普遍磷酸化作用使细菌防御失效。 |
Bartolec, T. |
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N/A |
Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses |
| 利用SPDE方法推导的二维扩散估计尺度依赖协变量响应 |
Lindmark, M. |
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N/A |
Estimating scale-dependent covariate responses using two-dimensional diffusion derived from the SPDE method |
| 有强有力的证据表明，在硬骨鱼之间发生了多次免疫基因的水平转移。 |
Policarpo, M. |
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N/A |
Strong evidence for multiple horizontal transfers of immune genes between teleost fishes |
| 鉴定PTGR2抑制剂作为糖尿病和肥胖症的新疗法 |
Chang, Y.-C. |
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N/A |
Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity |
| 脑脊液和血浆中apoE糖基化水平的增加与阿尔茨海默病生物标志物水平的降低有关。 |
Tharick, P. |
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N/A |
Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers |