| 男性与女性特异性GWAS结果之间的一致性有助于揭示复杂性状的潜在遗传结构。 |
Miller, A. K. |
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N/A |
Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits |
| 单粒子追踪揭示了PIEZO1的异质性扩散 |
Ly, A. T. |
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N/A |
Single-particle tracking reveals heterogeneous PIEZO1 diffusion |
| 一个基于细胞外基质模型的简单框架 |
Metzcar, J. |
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N/A |
A simple framework for agent-based modeling with extracellular matrix |
| GraphComm：一种基于图的深度学习方法，用于预测单细胞RNAseq数据中的细胞间通信 |
So, E. |
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N/A |
GraphComm: A Graph-based Deep Learning Method to Predict Cell-Cell Communication in single-cell RNAseq data |
| 人类问题解决中的自适应规划深度 |
Eluchans, M. |
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N/A |
Adaptive planning depth in human problem solving |
| 空间分岔：新皮层中功能模块化的出现 |
Wang, X.-J. |
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N/A |
Bifurcation in space: Emergence of function modularity in the neocortex |
| Eclipse：一个用于对齐两个或更多非靶向LC-MS代谢组学数据集的Python包 |
Hitchcock, D. S. |
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N/A |
Eclipse: A Python package for alignment of two or more nontargeted LC-MS metabolomics datasets |
| 在帕金森病小鼠模型中，刺激A13区域后运动功能的恢复 |
Kim, L. H. |
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N/A |
Restoration of locomotor function following stimulation of the A13 region in Parkinson's mouse models |
| 超越种族、民族和血统的基因组队列动态聚类 |
Mohsen, H. |
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N/A |
Dynamic clustering of genomics cohorts beyond race, ethnicity--and ancestry |
| 使用FibrilPaint来测定Tau淀粉样蛋白在液体中的长度 |
Aragones Pedrola, J. |
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N/A |
FibrilPaint to determine the length of Tau amyloids in fluids |
| 从有限经验原则中涌现的动态规律与临界点 |
Cobo-Lopez, S. |
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N/A |
Emerging dynamic regimes and tipping points from finite empirical principles |
| 使用双层连续模型预测蛋白质在不同膜成分中的曲率感应 |
Fu, Y. |
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N/A |
Predicting protein curvature sensing across membrane compositions with a bilayer continuum model |
| 更易解释的多组学调控网络，用于表征表型 |
Aguerralde-Martin, M. |
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N/A |
MORE interpretable multi-omic regulatory networks to characterize phenotypes |
| 对经过治疗的乳糜泻患者微生物组进行高分辨率分析，揭示了菌株水平的变异。 |
Slager, J. |
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N/A |
High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation |
| 二聚体R25CPTH(1-34)在体外激活甲状旁腺激素-1受体，并刺激骨质疏松雌性小鼠的骨形成。 |
Noh, M. |
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N/A |
Dimeric R25CPTH(1-34) Activates the Parathyroid Hormone-1 Receptor in vitro and Stimulates Bone Formation in Osteoporotic Female Mice |
| 使用蛋白质组范围的稳定性分析发现RNA-蛋白质分子钳 |
Goldstein, S. I. |
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Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays |
| 基于知识图谱的思维：一种用于泛癌问题解答的增强型LLMs框架 |
Feng, Y. |
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N/A |
Knowledge Graph-based Thought: a knowledge graph enhanced LLMs framework for pan-cancer question answering |
| 在花旗松、杰克松及其杂种中，对真菌病原菌松材线虫（Dothistroma septosporum）响应的遗传结构 |
Lu, M. |
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Genetic architecture underlying response to the fungal pathogen Dothistroma septosporum in lodgepole pine, jack pine, and their hybrids |
| 为原始的一型功能反应辩护：同时捕食多种猎物对频率和种群动态的影响 |
Novak, M. |
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N/A |
In defense of the original Type I functional response: The frequency and population-dynamic effects of feeding on multiple prey at a time |
| PhyloFunc：作为元蛋白质组数据分析中新生态指标的基于系统发育的功能距离 |
Wang, L. |
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PhyloFunc: Phylogeny-informed Functional Distance as a New Ecological Metric for Metaproteomic Data Analysis |
| 人类左心室环状RNA-微小RNA-信使RNA网络分析揭示了在缺血条件下circNPHP1具有新的促血管生成作用 |
Anwar, M. |
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Human left ventricle circRNA-miRNA-mRNA network analyses reveals a novel proangiogenic role for circNPHP1 under ischemic conditions |
| 使用深度学习和溶液散射预测RNA结构和动力学 |
Patt, E. |
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N/A |
Predicting RNA Structure and Dynamics with Deep Learning and Solution Scattering |
| 通过碱基堆积相互作用调节DNA四面体的稳定性 |
Punnoose, J. A. |
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N/A |
Tuning the stability of DNA tetrahedra with base-stacking interactions |
| 使用荧光寿命测量枯草芽孢杆菌膜电位值的方法研究 |
Roy, D. |
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N/A |
Towards optical measurements of membrane potential values in Bacillus subtilis using fluorescence lifetime |
| EnVhog：通过大量HMM配置文件对地球上病毒蛋白家族的扩展视图。 |
Bucio, R. E. P. |
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N/A |
EnVhog: an extended view of the viral protein families on Earth through a vast collection of HMM profiles. |
| 借助3D-SOCS技术窥探野生鸣禽的世界：同步视频捕捉与姿态估算 |
Chimento, M. |
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N/A |
Peering into the world of wild passerines with 3D-SOCS: synchronized video capture and posture estimation |
| C5aR1抑制减轻了颅脑放射引起的认知功能下降。 |
Krattli, R. P. |
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N/A |
C5aR1 inhibition alleviates cranial radiation-induced cognitive decline |
| 对检测到的病毒在Peromyscus maniculatus物种复合体（啮齿目：仓鼠科）中的分布和流行情况的系统综述 |
Finkbeiner, A. |
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N/A |
A Systematic Review of the Distribution and Prevalence of Viruses Detected in the Peromyscus maniculatus Species Complex (Rodentia: Cricetidae) |
| 钠负荷正常血压小鼠的血管重塑存在性别相关差异 |
Viegas, K. A. d. S. |
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N/A |
Sex-related differences in vascular remodeling of sodium overloaded normotensive mice |
| 从组织学到人类杏仁核的宏观功能 |
Auer, H. |
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N/A |
From histology to macroscale function in the human amygdala |
| 小鼠运动技能学习能力的发展时间进程 |
Kim, T. |
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N/A |
Developmental timecourse of aptitude for motor skill learning in mouse |
| 一种整合基因组和Tn-Seq数据以识别多种细菌物种中常见体内适应性机制的新方法 |
Fouts, D. E. |
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A novel method for integrating genomic and Tn-Seq data to identify common in vivo fitness mechanisms across multiple bacterial species |
| STAMBPL1通过与FOXO1相互作用激活GRHL3/HIF1A/VEGFA轴，从而促进三阴性乳腺癌中的血管生成。 |
Fang, H. |
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STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer |
| 机械负荷和激素变化对容量超载期间离心肥大的贡献：基于逻辑网络模型的贝叶斯分析。 |
Bracamonte, J. H. |
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Contributions of mechanical loading and hormonal changes to eccentric hypertrophy during volume overload: a Bayesian analysis using logic-based network models. |
| 为什么端粒的长度是这样的？来自系统发育比较分析的见解 |
Benson, D. M. |
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N/A |
Why are telomeres the length that they are? Insight from a phylogenetic comparative analysis |
| 在破伤风毒素癫痫模型中减少的突触异质性：来自计算建模的见解 |
Zarei Eskikand, P. |
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N/A |
Reduced Synaptic Heterogeneity in a Tetanus ToxinModel of Epilepsy: Insights from ComputationalModeling |
| 神经肽依赖的尖峰时间精确性和昼夜节律输出神经元的可塑性 |
Chong, B. |
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N/A |
Neuropeptide-dependent spike time precision and plasticity in circadian output neurons |
| 大数据，小偏差：协调基于扩散MRI的结构连接体以减轻数据整合中的站点相关偏差 |
Shen, R. S. |
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N/A |
Big Data, Small Bias: Harmonizing Diffusion MRI-Based Structural Connectomes to Mitigate Site-Related Bias in Data Integration |
| 大鼠从空间距离到社交距离的信息传递：对后顶叶皮层在空间-社交整合中作用的启示 |
Wise, T. B. |
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N/A |
Information transfer from spatial to social distance in rats: implications for the role of the posterior parietal cortex in spatial-social integration |
| 酮生成通过超越整体脂肪氧化率的机制，保护机体免受MASLD-MASH（即多器官脂肪性肝病-代谢相关脂肪性肝病）进展的影响。 |
Queathem, E. D. |
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N/A |
Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rate |
| 双面蛋白质纳米材料计算设计 |
Rankovic, S. |
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N/A |
Computational design of bifaceted protein nanomaterials |
| 通过细胞周期实现核组织的三维记忆 |
Fujishiro, S. |
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N/A |
Three-dimensional memory of nuclear organization through cell cycles |
| G-四链体配体RHPS4通过阻断电离辐射诱导的线粒体质量和活性的增加，削弱了细胞的辐射抗性。 |
Tricot, S. |
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N/A |
G-quadruplex ligand RHPS4 compromises cellular radio-resistance by blocking the increase in mitochondrial mass and activity induced by ionising irradiation. |
| 混合长度基因组测序（blend-seq）：结合短读长与低覆盖率长读长以最大化变异发现 |
Magner, R. |
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N/A |
Blended Length Genome Sequencing (blend-seq): Combining Short Reads with Low-Coverage Long Reads to Maximize Variant Discovery |
| AlphaFold 对整个基因组的预测概览 |
Cazals, F. |
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N/A |
AlphaFold predictions on whole genomes at a glance |
| 评估人类非编码RNA符号的鲁棒性 |
Prasetyo, N. K. |
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N/A |
Assessing the robustness of human ncRNA notations |
| 一种新型HLA II类抗原呈递预测算法，揭示了与KRAS G12C特异性相关的免疫原性CD4表位 |
Sprague, D. |
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N/A |
A novel HLA Class II presentation prediction algorithm deciphers immunogenic CD4 epitopes specific to KRAS G12C |
| 细胞优先调节细胞质量密度 |
Fu, J. |
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N/A |
Cells Prioritize the Regulation of Cell Mass Density |
| OrthoHMM：利用隐马尔可夫模型改进直系同源群组的推断 |
Steenwyk, J. L. |
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N/A |
OrthoHMM: Improved Inference of Ortholog Groups using Hidden Markov Models |
| 恢复阿尔茨海默病中的振荡动力学：一种关于血清素类致幻剂效应的层级全脑模型 |
Gendra, J. C. |
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N/A |
Restoring Oscillatory Dynamics in Alzheimer's Disease: A Laminar Whole-Brain Model of Serotonergic Psychedelic Effects |
| 牛子宫内膜类器官：研究哺乳动物胚胎与母体相互作用的新工具 |
Edge, J. C. |
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N/A |
Bovine endometrial organoids: A new tool to study conceptus-maternal interactions in mammals |
| 谁说的？用空间音频和360度视频解读复杂的珊瑚礁声景 |
Dantzker, M. S. |
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N/A |
Who said that? Deciphering Complex Coral Reef Soundscapes with Spatial Audio and 360 Degree Video |
| 一个整合了低氧、机械感应和TGF-β信号传导的布尔网络模型，揭示了表型可塑性和突变在肿瘤转移中的作用。 |
Greene, G. |
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N/A |
A Boolean network model of hypoxia, mechanosensing and TGF-β signaling captures the role of phenotypic plasticity and mutations in tumor metastasis |
| 一种用于预测蛋白质内在无序区域相互作用的深度学习方法 |
Majila, K. |
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N/A |
A deep learning method for predicting interactions for intrinsically disordered regions of proteins |
| 一个用于自主AI驱动药物发现的框架 |
Selinger, D. W. |
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N/A |
A Framework for Autonomous AI-Driven Drug Discovery |
| 鉴定PTGR2抑制剂作为糖尿病和肥胖的新疗法 |
Chang, Y.-C. |
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N/A |
Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity |
| 多模态单细胞数据推断基因调控网络方法的比较与评估 |
Badia-i-Mompel, P. |
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N/A |
Comparison and evaluation of methods to infer gene regulatory networks from multimodal single-cell data |
| 协调的脊髓运动神经网络动态产生于特定细胞类型的连接模式 |
Wandler, F. D. |
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N/A |
Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns |
| 内在功能连接描绘了跨模态语言功能。 |
Salvo, J. J. |
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N/A |
Intrinsic functional connectivity delineates transmodal language functions |
| 祖先序列重建对位点间进化异质性和上位性的稳健性 |
Muniz-Trejo, R. |
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N/A |
Robustness of ancestral sequence reconstruction to among-site evolutionary heterogeneity and epistasis |
| MCL-1调控少突胶质细胞发育过程中的细胞转变 |
Gil, M. |
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N/A |
MCL-1 regulates cellular transitions during oligodendrocyte development |
| 人类几丁质三糖酶-1催化装置的机制及其通过首创的OATD-01抑制剂的双重失活模式。 |
Niedzialek, D. |
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N/A |
Mechanism of catalytic apparatus of human chitotriosidase-1 and its dual inactivation mode by the first-in-class OATD-01 inhibitor. |
| I2SIM：通过图像干扰与空间频谱优化提升高保真各向同性超分辨率 |
He, E. |
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N/A |
I2SIM: Boosting High-Fidelity Isotropic Super-Resolution with Image Interference and Spatial-Spectrum Optimization |
| 气候驱动了西加那利群岛蜥蜴（Gallotia galloti）长期的地貌变化和短期的快速进化。 |
Gilbert, E. |
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N/A |
Climate drives long-term landscape and rapid short-term promoter evolution in the Western Canaries lizard, Gallotia galloti |
| 25-羟基胆固醇有效抑制日本脑炎病毒在Vero细胞中的感染。 |
Archana, K. |
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N/A |
25 Hydroxy Cholesterol Effectively Inhibits Japanese Encephalitis Virus Infection in Vero Cells |
| 基于电子密度的有效且可靠的从头分子设计和先导优化，采用ED2Mol方法 |
Li, M. |
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N/A |
Electron-density informed effective and reliable de novo molecular design and lead optimization with ED2Mol |
| 通过条件复杂度约束表型转变概率 |
Dingle, K. |
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N/A |
Bounding phenotype transition probabilities via conditional complexity |
| G-四链体通过重塑能量景观来催化蛋白质折叠 |
Huang, Z. |
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N/A |
G-quadruplexes catalyze protein folding by reshaping the energetic landscape |
| 杨树木材纤维G层中类似束蛋白的阿拉伯半乳聚糖蛋白的免疫定位 |
Takeuchi, M. - |
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N/A |
Immunolocalization of fasciclin-like arabinogalactan proteins in the G-layers of poplar tension wood fibers |
| 德国北部牛场寄生虫对苯并咪唑和聚醚类药物的抗药性 |
Ehnert, P. |
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N/A |
Anthelmintic resistance against benzimidazoles and macrocyclic lactones in strongyle populations on cattle farms in northern Germany |
| 细菌表面上的血红素结合DNA结构促进了胞外电子传递。 |
Ajunwa, O. M. |
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N/A |
Hemin-binding DNA structures on the surface of bacteria promote extracellular electron transfer |
| 巴西卡廷加干旱地区的土壤微生物群 |
Tacca, L. M. A. d. |
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N/A |
The Soil Microbiome of the Caatinga Drylands in Brazil |
| 利用禽致病性大肠杆菌（APEC）系统发育群的基因组规模代谢重建来鉴定谱系特异性代谢途径 |
Long, H. |
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N/A |
Use of Genome Scale Metabolic Reconstructions of Avian Pathogenic Escherichia coli (APEC) phylogroups for the identification of lineage-specific metabolic pathways |
| 通过miRNA靶向CMP-唾液酸合酶来描绘唾液酸化的调控格局 |
Jame-Chenarboo, F. |
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N/A |
Profiling the Regulatory Landscape of Sialylation through miRNA Targeting of CMP- Sialic Acid Synthetase |
| 城市适应性野生动物中人畜共患病毒的风险评估 |
Wei, X. |
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N/A |
Risk assessment of zoonotic viruses in urban-adapted wildlife |
| 两个虾的故事 - 两种共域虾类物种的物种形成与种群动态，来自热液喷口 |
Methou, P. |
PDF |
N/A |
A tale of two shrimps - Speciation and demography of two sympatric shrimp species from hydrothermal vents |
| 两个虾的故事——来自热液喷口的两种同域虾种的物种形成与种群动态 |
Methou, P. |
PDF |
N/A |
A tale of two shrimps - Speciation and demography of two sympatric shrimp species from hydrothermal vents |
| 探索褐藻中的减数分裂：模式褐藻Ectocarpus中的减数分裂轴蛋白 |
Kane, E. I. |
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N/A |
Exploring Meiosis in Brown Algae: Meiotic Axis Proteins in the model brown alga Ectocarpus |
| 热力学稳定性调控伴侣蛋白介导的α-突触核蛋白纤维解聚 |
Fricke, C. |
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N/A |
Thermodynamic Stability Modulates Chaperone-Mediated Disaggregation of α-Synuclein Fibrils |
| 基于连续滴定的方法用于非共价相互作用的快速溶液内分析 |
Willmer, P. |
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N/A |
Continuous Titration Based Method For Rapid In-solution Analysis Of Non-covalent Interactions |
| 环核苷酸门控CNGA1离子通道中阳离子渗透与孔电压敏感性的原子机制 |
Liu, H. |
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N/A |
Atomistic Mechanism of Cation Permeation and Pore Voltage Sensitivity in Cyclic Nucleotide-Gated CNGA1 Ion Channel |
| 通过基因组挖掘在湿链霉菌中发现并合成Nyuzenamides D和E |
Lum, K. Y. |
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N/A |
Discovery and Biosynthesis of Nyuzenamides D and E by Genome Mining in Streptomyces hygroscopicus |
| 甘油体磷酸烯醇丙酮酸羧激酶CRISPR/Cas9缺失及其在克氏锥虫后循环发生和哺乳动物宿主感染性中的作用 |
Vieira, C. S. D. |
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N/A |
Glycosomal phosphoenolpyruvate carboxykinase CRISPR/Cas9-deletion and its role in Trypanosoma cruzi metacyclogenesis and infectivity in mammalian host |
| 牙龈卟啉单胞菌脂多糖A 1-磷酸酶LpxE具有独特的特性，其活性需要一个功能性的IX型分泌系统的支持。 |
Wang, S. |
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N/A |
The Porphyromonas gingivalis lipid A 1-phosphatase LpxE has unique features and requires a functional type IX secretion system for its activity |
| 系统性功能评估宿主中抗噬菌体系统的本征功能 |
David, E. |
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N/A |
Systematic functional assessment of antiphage systems in their native host |
| 鼠疫耶尔森菌能主动抑制人中性粒细胞产生胞外囊泡。 |
Sheneman, K. R. |
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N/A |
Yersinia pestis actively inhibits the production of extracellular vesicles by human neutrophils |
| cryoTIGER：基于深度学习的倾斜插值生成器，用于增强冷冻电子断层扫描中的重建 |
Majtner, T. |
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N/A |
cryoTIGER: Deep-Learning Based Tilt Interpolation Generator for Enhanced Reconstruction in Cryo Electron Tomography |
| 重组对恶性疟原虫疟疾多药抗性进化的影响 |
Tran, K. T. |
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N/A |
Effects of recombination on multi-drug resistance evolution in Plasmodium falciparum malaria |
| 受神经普通微分方程启发的动力学模型参数化方法 |
Lent, P. v. |
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N/A |
Neural Ordinary Differential Equations Inspired Parameterization of Kinetic Models |
| 激素调控的Sertoli细胞中mRNA在核糖体上的分布动态 |
Leray, X. |
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N/A |
Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells |
| 视网膜拓扑映射数据允许在不同数据集之间进行准确的参与者匹配。 |
Schwarzkopf, D. S. |
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N/A |
Retinotopic mapping data permit accurate matching of participants across different datasets |
| 并非所有跨模态反应都可以用面部运动来解释。 |
Olsen, T. R. |
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N/A |
Not all cross-modal responses are explained by face movements |
| 皮层相似网络的遗传结构 |
Sebenius, I. |
PDF |
N/A |
The genetic architecture of cortical similarity networks |
| 转录组破坏和功能性低活性在DYT-SGCE MGE模式抑制性神经元中 |
Li, Z. |
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N/A |
Transcriptomic disruption and functional hypoactivity in DYT-SGCE MGE-patterned inhibitory neurons |
| 限时进食是否伴随酮症以一种组织特异性的方式影响老年大鼠代谢相关基因的表达。 |
Ding, S. |
PDF |
N/A |
Time restricted feeding with or without ketosis influences metabolism-related gene expression in a tissue-specific manner in aged rats |
| 声音引发的神经可塑性变化区分了耳鸣与非耳鸣小鼠 |
Fabrizio-Stover, E. M. |
PDF |
N/A |
Sound-Evoked Plasticity Differentiates Tinnitus from Non-Tinnitus Mice |
| 时间上重叠的机制在体内使克隆B细胞的反应多样化。 |
Skinner, O. P. |
PDF |
N/A |
Temporally overlapping mechanisms diversify clonal B cell responses in vivo. |
| 异源免疫策略开发出针对BK病毒具有广泛反应性的人源单克隆抗体 |
Duty, J. A. |
PDF |
N/A |
Heterologous immunization strategy developed broadly reactive human monoclonal antibodies against the BK virus |
| 氟喹诺酮类药物治疗引起的多样表型和突变谱 |
Mohiuddin, S. G. |
PDF |
N/A |
The Diverse Phenotypic and Mutational Landscape Induced by Fluoroquinolone Treatment |
| 创新的肉碱喂养大鼠模型揭示了白藜芦醇丁酸酯在降低TMAO和心血管风险中的多重机制作用 |
Hou, C.-Y. |
PDF |
N/A |
Innovative Carnitine-Fed Rats Model Reveals Resveratrol Butyrate Ester's Multimechanistic Role in Reducing TMAO and Cardiovascular Risk |
| 线粒体损伤会引发治疗诱导的衰老。 |
Baltira, C. |
PDF |
N/A |
Mitochondrial damage triggers therapy-induced senescence |
| 一种用于评估E3连接酶在靶向蛋白质降解中应用的细胞内方法。 |
Zheng, Y. |
PDF |
N/A |
An in-cell approach to evaluate E3 ligases for use in targeted protein degradation. |
| 一份关于西北欧节肢动物生活史和生态特征的深入数据集 |
Logghe, G. |
PDF |
N/A |
An in-depth dataset of northwestern European arthropod life histories and ecological traits |
| 加利福尼亚特有橡树对气候变暖的不适应反应，可通过其生长和存活的年际变化进行预览。 |
Goetz, A. R. B. |
PDF |
N/A |
Maladaptive response of an endemic California oak to climatic warming is previewed by interannual variation in growth and survival |
| 破译硫内酰胺化机制在硫内酰胺霉素生物合成中的作用 |
Guo, J. |
PDF |
N/A |
Deciphering the thiolactonization mechanism in thiolactomycin biosynthesis |
| 基因先锋：一个全面的Python包，用于识别癌症中的关键基因和模块 |
Taheri, G. |
PDF |
N/A |
GenePioneer: A Comprehensive Python Package for Identification of Essential Genes and Modules in Cancer |
| 蛋白质序列内在无序特征的概率注释 |
Malhis, N. |
PDF |
N/A |
Probabilistic Annotations of Protein Sequences for Intrinsically Disordered Features |
| 力传递是机械细胞竞争的主调控因子。 |
Schoenit, A. |
PDF |
N/A |
Force transmission is a master regulator of mechanical cell competition |
| 最后手段抗生素达托霉素展示了两种独立的抗菌作用机制。 |
Buttress, J. A. |
PDF |
N/A |
The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action |
| 发育延迟确保了局部凋亡诱导下整体组织大小的稳定性。 |
Staneva, R. |
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N/A |
Developmental delay ensures global tissue size robustness upon local induction of apoptosis |
| 在相对简单的生命周期中，基因重复和非随机基因组织的减少特征塑造了阶段特异性基因表达模式 |
DuBose, J. G. |
PDF |
N/A |
Reduced signatures of gene duplication and non-random gene organization in shaping stage-specific patterns of gene expression across a relatively simple life cycle |
| 蛋白质组规模定量分析驱动无序蛋白质凝聚体形成的相互作用 |
Norrild, R. K. |
PDF |
N/A |
Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins |
| Syn-tasiR-VIGS：基于最小前体衍生的合成转录活性小干扰RNA在植物中实现病毒介导的靶向RNAi |
Cisneros, A. E. |
PDF |
N/A |
Syn-tasiR-VIGS: Virus-Based Targeted RNAi in Plants By Synthetic Trans Acting Small Interfering RNAs Derived from Minimal Precursors |
| 联合模型揭示了人类皮层下结构对选择和学习行为的基础作用 |
Miletic, S. |
PDF |
N/A |
Joint models reveal human subcortical underpinnings of choice and learning behaviour |
| 基于代理的枯草芽孢杆菌生物膜代谢信号振荡模型 |
Mulder, O. |
PDF |
N/A |
An Agent-Based Model of Metabolic Signaling Oscillations in Bacillus subtilis Biofilms |
| 盘星类（Stentor pyriformis）是一种巨大的细胞，其细胞生物学和基因组的特点在于，它将共生藻类嵌入到微管网络中。 |
Boudreau, v. |
PDF |
N/A |
The cell biology and genome of Stentor pyriformis, a giant cell that embeds symbiotic algae in a microtubule meshwork |
| 吸引本地传粉者到城市绿地 |
Mata, L. |
PDF |
N/A |
Attracting indigenous pollinators to urban greenspaces |
| 泛基因组小麦品种种子性状的多组学可塑性 |
Bose, U. |
PDF |
N/A |
Multiomics plasticity in seed traits of pan-genome wheat cultivars |
| 基于单倍型的进化历史揭示了大麦的驯化过程 |
Guo, Y. |
PDF |
N/A |
A haplotype-based evolutionary history of barley domestication |
| 一个远程抑制系统调控寄生植物吸器数量 |
Kokla, A. |
PDF |
N/A |
A long-distance inhibitory system regulates haustoria numbers in parasitic plants |
| 一种在伽蓝菜属植物中用于研究生物节律调控景天酸代谢（CAM）的分子元素的工具：荧光素酶报告基因成像技术 |
Pritchard, J. H. |
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N/A |
A promoter::luciferase reporter gene imaging toolkit in Kalanchoë laxiflora reveals molecular elements responsible for the circadian regulation of Crassulacean acid metabolism (CAM) |
| 延伸的下胚轴5调控拟南芥中光介导的角鲨烯生物合成和发育 |
Pathak, P. K. |
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N/A |
ELONGATED HYPOCOTYL 5 regulates light-mediated squalene biosynthesis and development in Arabidopsis thaliana |
| 空间转录组学揭示了在细胞分辨率下发育中的小麦花序中的表达梯度 |
Long, K. A. |
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N/A |
Spatial Transcriptomics Reveals Expression Gradients in Developing Wheat Inflorescences at Cellular Resolution |
| 辅酶M：一种作为农业生物刺激素的古菌抗氧化剂 |
Brown, J. H. |
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N/A |
Coenzyme M: An Archaeal Antioxidant as an Agricultural Biostimulant |
| 温暖的环境温度会改变细胞命运，从而减少拟南芥的气孔生成。 |
Saiz-Perez, J. |
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N/A |
Warm temperature modifies cell fates to reduce stomata production in Arabidopsis |
| TUTase URT1调控种子转录组及其初级休眠 |
Peter, J. |
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N/A |
The TUTase URT1 regulates the transcriptome of seeds and their primary dormancy |
| 欧洲白蜡树更新后的长读长基因组揭示了MADS-box基因在抵御白蜡树枯萎病耐受机制中的重要性 |
Franco Ortega, S. |
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N/A |
Fraxinus excelsior updated long-read genome reveals the importance of MADS-box genes in tolerance mechanisms against ash dieback |
| 有机肥与无机肥配合施用对高丹草土壤及产量的影响 |
Yi, Z. |
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N/A |
Effects of combined application of organic fertilizer and inorganic fertilizer on soil and yield of Gaodan grass |
| 人工生态系统中植物的高光谱分割 |
Zwart, P. H. |
PDF |
N/A |
Hyperspectral Segmentation of Plants in Fabricated Ecosystems |
| 利用定量蛋白质组学技术研究Humalite施用对田间种植小麦（Triticum aestivum L.）分子影响的研究 |
Grubb, L. E. |
PDF |
N/A |
Defining the molecular impacts of Humalite application on field-grown wheat (Triticum aestivum L.) using quantitative proteomics |
| 地质和气候因素在华盛顿喀斯喀特山脉的峰峦之间驱动了高山植物组成的变异。 |
Ertsgaard, E. W. |
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N/A |
Geology and climate drive alpine plant compositional variation among peaks in the Cascade Range of Washington |
| 类似炎症的环境限制了铜绿假单胞菌群体感应的丧失 |
Fu, T. |
PDF |
N/A |
Inflammation-like environments limit the loss of quorum sensing in Pseudomonas aeruginosa |
| 应用GRF-GIF嵌合体增强番茄基因组编辑中的植物再生 |
Swinnen, G. |
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N/A |
Application of a GRF-GIF chimera enhances plant regeneration for genome editing in tomato |
| 被子植物种子的生命周期遵循一个发育的反向沙漏模型。 |
Sami, A. A. |
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N/A |
The angiosperm seed life cycle follows a developmental reverse hourglass |
| 酵母中对Killer Toxin K28的抗性依赖于COG复合体介导的防御因子Ktd1的运输。 |
Laidlaw, K. |
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N/A |
Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1 |
| 一种在植物中高效产生结构变异的方法 |
Bechen, L. L. |
PDF |
N/A |
A simple method to efficiently generate structural variation in plants |
| 揭示三种十字花科作物中独特的代谢组和转录组特征 |
Zhang, L. |
PDF |
N/A |
Unveiling unique metabolomic and transcriptomic profiles in three Brassicaceae crops |
| 云杉杂交种表现出比其生态上差异较大的亲本物种更优越的累积生长量和对气候异常的中间响应。 |
Reed-Metayer, E. |
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N/A |
Spruce hybrids show superior cumulative growth and intermediate response to climate anomalies, as compared to their ecologically divergent parental species |
| 通过PAP和DXO1调控拟南芥中共翻译mRNA降解的机制 |
Carpentier, M.-C. |
PDF |
N/A |
Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis |
| 热应激促使再生扁虫Macrostomum lignano中的LTR逆转录转座子转录。 |
Ustyantsev, K. |
PDF |
N/A |
Heat stress drives transcription of LTR retrotransposons in the regenerative flatworm Macrostomum lignano |
| 分阶段的基因组组装和泛基因组图谱展示了日本和沙特阿拉伯人群的基因组特征。 |
Kulmanov, M. |
PDF |
N/A |
Phased genome assemblies and pangenome graphs of human populations of Japan and Saudi Arabia |
| 一项针对人类前额叶皮层体细胞嵌合现象的多平台个性化评估 |
Zhou, W. |
PDF |
N/A |
A personalized multi-platform assessment of somatic mosaicism in the human frontal cortex |
| 肠道微生物群促进帕金森病小鼠模型大脑中的线粒体呼吸作用 |
Morais, L. H. |
PDF |
N/A |
The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model |
| 对延髓和脑桥网络中阿片类药物引起呼吸抑制潜在机制的建模洞察 |
Olsen, W. L. |
PDF |
N/A |
Modeling Insights into Potential Mechanisms of Opioid-Induced Respiratory Depression within Medullary and Pontine Networks |
| 标准化方法用于在实验室环境下饲养蛾类幼虫——烟草天蛾（Manduca sexta）。 |
Spencer, E. K. |
PDF |
N/A |
Standardized methods for rearing a moth larva, Manduca sexta, in a laboratory setting |
| Septin细胞骨架将Cdc42 GAP Rga4排除在生长部位之外，以促进分裂酵母的双极性。 |
McDuffie, J. |
PDF |
N/A |
The Septin Cytoskeleton excludes the Cdc42 GAP Rga4 from growing sites to promote bipolarity in fission yeast |
| LC3在自噬体上形成功能性纳米团簇 |
Fatihi, S. |
PDF |
N/A |
LC3 forms functional nanocluster on autophagosome |
| 共存液相界面间的传输动力学 |
Hubatsch, L. |
PDF |
N/A |
Transport kinetics across interfaces between coexisting liquid phases |
| 利用深度学习设计针对细胞内感染的多模态抗生素 |
Cesaro, A. |
PDF |
N/A |
Design of multimodal antibiotics against intracellular infections using deep learning |
| 通过LoxPsym介导的酵母上游激活序列重排实现体内通路优化 |
Ruehmkorff, C. |
PDF |
N/A |
In Vivo Pathway Optimization in Yeast via LoxPsym-Mediated Shuffling of Upstream Activating Sequences |
| 从生物学角度构建图神经网络以模拟大脑动态并推断连接性 |
Gupta, A. |
PDF |
N/A |
Biologically Plausible Graph Neural Networks for Simulating Brain Dynamics and Inferring Connectivity |
| 5岁儿童的努力控制与大脑皮质结构：来自FinnBrain出生队列研究的发现 |
Frantti, M. |
PDF |
N/A |
Effortful control and cortical brain structure in 5-year-old children: findings from the FinnBrain birth cohort study |
| 一个分子定义明确的脑回路模块，用于调节类似恐慌的防御状态 |
Zhao, M. |
PDF |
N/A |
A molecularly defined brain circuit module for regulating the panic-like defensive state |
| 人类对形状的感知会自发地发现新颖但自然的刺激的生物起源。 |
Dehn, K. I. |
PDF |
N/A |
Human shape perception spontaneously discovers the biological origin of novel, but natural, stimuli |
| 中年和老年自闭症谱系成年人的BOLD信号变异性降低 |
Pedrahita, S. |
PDF |
N/A |
Decreased BOLD signal variability in middle-aged and older adults on the Autism Spectrum |
| 大鼠皮层微观结构相似性网络的发展及其对早期生活压力的敏感性 |
Smith, R. L. |
PDF |
N/A |
Development and early life stress sensitivity of the rat cortical microstructural similarity network |
| 蛋白激酶G抑制在一种新的常染色体显性视网膜色素变性小鼠模型中，保护了光感受器的生存能力和功能。 |
Zhu, Y. |
PDF |
N/A |
Protein kinase G inhibition preserves photoreceptor viability and function in a new mouse model for autosomal dominant retinitis pigmentosa |
| 猴子决策参考点的神经表示 |
Nguyen, D. |
PDF |
N/A |
Neuronal representation of the decisional reference point in monkeys |
| 星形胶质细胞中Frataxin的缺乏会驱动镰状细胞病小鼠的神经认知功能障碍。 |
Novelli, E. M. |
PDF |
N/A |
Frataxin deficiency in the astrocytes drives neurocognitive impairment in sickle cell disease mice |
| 在模糊处理过程中，与前额叶皮层的连接和蓝斑活动的年龄相关增加 |
Dave, A. |
PDF |
N/A |
Age-related Increase in Locus Coeruleus Activity and Connectivity with Prefrontal Cortex during Ambiguity Processing |
| 生态证据综合中的已知未知和模型选择 |
Blowes, S. A. |
PDF |
N/A |
Known unknowns and model selection in ecological evidence synthesis |
| 生态特化与同域形态的牙齿特征变异 |
Jonsdottir, G. O. |
PDF |
N/A |
Variation of tooth traits in ecologically specialized and sympatric morphs |
| Flashzoi：一种用于加速基因组分析的增强型Borzoi模型 |
Hingerl, J. C. |
PDF |
N/A |
Flashzoi: An enhanced Borzoi model for accelerated genomic analysis |
| 使用iconPCR进行16S文库制备可以提高数据质量和实验流程。 |
Patel, P. |
PDF |
N/A |
The use of iconPCR for 16S library preparation improves data quality and workflow |
| 一种改进的神经网络模型能够在具有挑战性的条件下进行蠕虫追踪，并提高表型筛选中的信噪比。 |
Weheliye, W. H. |
PDF |
N/A |
An improved neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens |
| 化学遗传激活内侧前额叶皮层投射至伏隔核壳部可抑制EcoHIV感染小鼠的可卡因引发复吸 |
Xie, Q. |
PDF |
N/A |
Chemogenetic Activation of Medial Prefrontal Cortex Projections to the Nucleus Accumbens Shell Suppresses Cocaine-Primed Reinstatement in EcoHIV Infected Mice |
| 应用计算蛋白质设计来设计affibodies，用于血管内皮生长因子和血小板衍生生长因子的亲和力控制递送。 |
Svendsen, J. E. |
PDF |
N/A |
Applying computational protein design to engineer affibodies for affinity-controlled delivery of vascular endothelial growth factor and platelet-derived growth factor |
| 基于牛奶光谱特征的酮病牛识别：基于Aquaphotomics原理的化学计量学建模方法 |
Giovinazzo, S. |
PDF |
N/A |
Identification of ketotic cattle based on milk spectroscopic characteristics: a chemometric modelling approach built upon the principles of Aquaphotomics |
| 遥控无线生物电子设备用于氟西汀治疗以促进猪模型中的伤口愈合 |
Li, H. |
PDF |
N/A |
Remote-Controlled Wireless Bioelectronics for Fluoxetine Therapy to Promote Wound Healing in a Porcine Model |
| 用DBCO标记金黄色葡萄球菌表面以进行点击化学介导的敏感货物沉积的新方法 |
Baryakova, T. |
PDF |
N/A |
Novel approaches to label the surface of S. aureus with DBCO for click chemistry-mediated deposition of sensitive cargo |
| 设计和验证用于猪模型中自动化伤口监测的可穿戴成像系统 |
HEE, W. S. |
PDF |
N/A |
Design and Validation of a Wearable Imaging System for Automated Wound Monitoring in Porcine Model |
| 使用TopKAT检测多重空间蛋白质组学影像中的临床相关拓扑结构 |
Samorodnitsky, S. |
PDF |
N/A |
Detecting Clinically Relevant Topological Structures in Multiplexed Spatial Proteomics Imaging Using TopKAT |
| 番茄植株中的腺毛破裂是一种超快且敏感的防御机制，用以抵御昆虫。 |
Popowski, J. |
PDF |
N/A |
Glandular Trichome Rupture in Tomato Plants is an Ultra-Fast & Sensitive Defense Mechanism Against Insects |
| 大麦病害筛选：一种用于检测Ramularia collo-cygni、Rhynchosporium graminicola和Pyrenophora teres的多重数字滴液PCR方法 |
Zia, R. |
PDF |
N/A |
Barley disease screening: a multiplex digital droplet PCR approach for the detection of Ramularia collo-cygni, Rhynchosporium graminicola and Pyrenophora teres |
| 早期催产素可挽救脆性X综合征小鼠模型中的海马突触可塑性和情景记忆 |
Chavez, J. |
PDF |
N/A |
Early-life Oxytocin Rescues Hippocampal Synaptic Plasticity and Episodic Memory in a Mouse Model of Fragile X Syndrome |
| tDCS的神经机制：来自具有现实电场强度的活体啮齿动物模型的见解 |
Chen, L. |
PDF |
N/A |
Neural Mechanisms of tDCS: Insights from an In-Vivo Rodent Model with Realistic Electric Field Strengths |
| 中央凹视觉中的不对称性 |
Jenks, S. K. |
PDF |
N/A |
Asymmetries in foveal vision |
| 小鼠Timothy综合征模型中初级视觉皮层生理与功能的紊乱 |
Craddock, R. |
PDF |
N/A |
Disruptions in Primary Visual Cortex Physiology and Function in a Mouse Model of Timothy Syndrome |
| dFCExpert：利用模块化和状态专家学习动态功能连接模式 |
Chen, T. |
PDF |
N/A |
dFCExpert: Learning Dynamic Functional Connectivity Patterns with Modularity and State Experts |
| 光损伤中光感受器细胞死亡机制 |
Bruera, M. G. |
PDF |
N/A |
Photoreceptor cell death mechanism in light damage |
| 高效集成编码的动力学 |
Ni, L. |
PDF |
N/A |
Dynamics of efficient ensemble coding |
| 在活体斑马鱼中，kif5Aa缺失导致的麻醉敏感性变化与线粒体运动改变有关。 |
Bedell, V. |
PDF |
N/A |
In vivo changes in zebrafish anesthetic sensitivity in response to the loss of kif5Aa are associated with the alteration of mitochondrial motility |
| 在初级视皮层（V1）超柱中动态分组进行中的活动 |
Zhang, R. |
PDF |
N/A |
Dynamic Grouping of Ongoing Activity in V1 Hypercolumns |
| 运动处理自适应循环神经网络中的能效和灵敏度优势 |
Mohan, V. |
PDF |
N/A |
Energy efficiency and sensitivity benefits in a motion processing adaptive recurrent neural network |
| 区分Peromyscus leucopus骨髓来源的巨噬细胞以表征其对伯氏疏螺旋体和脂多糖的反应 |
Wells, C. C. |
PDF |
N/A |
Differentiating Peromyscus leucopus bone marrow-derived macrophages for characterization of responses to Borrelia burgdorferi and lipopolysaccharide |
| CD4+ T细胞为力敏感的TCR:pMHC相互作用创造了一个稳定的机械环境。 |
Schrangl, L. |
PDF |
N/A |
CD4+ T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions |
| 急性传染性单核细胞增多症会产生持久的功能性EBNA-1抗体，这些抗体具有高度的交叉反应性，能够识别α晶体β。 |
Ganta, K. K. |
PDF |
N/A |
Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta |
| 人类B1类G蛋白偶联受体（GPCR）对细胞膜脂质的调节 |
Chao, K. W. |
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N/A |
Human class B1 GPCR modulation by plasma membrane lipids |
| Enterobactin通过一种独立于二价金属转运蛋白DMT1的机制，将铁带入秀丽隐杆线虫和哺乳动物的肠道细胞。 |
Sewell, A. K. |
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N/A |
Enterobactin carries iron into C. elegans and mammalian intestinal cells by a mechanism independent of divalent metal transporter DMT1 |
| NANOG增强子的发现及其在人胚胎干细胞自我更新和分化中的关键作用 |
Yan, J. |
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N/A |
Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells |
| 海洋鱼类在生物荧光发射光谱上表现出显著的多样性。 |
Carr, E. |
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N/A |
Marine fishes exhibit exceptional variation in biofluorescent emission spectra |
| 超越社区加权平均值：量化性状分布以检测社区构建模式 |
Melero, Y. |
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N/A |
Beyond community-weighted means: quantifying trait distributions for detecting community assembly patterns |
| 主要组织相容性复合体多样性对社会性哺乳动物适应性的性别依赖性影响 |
Schubert, N. |
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N/A |
Sex-dependent influence of major histocompatibility complex diversity on fitness in a social mammal |
| 通过全基因组关联研究，鉴定出SENP7和UTF1/VENTX作为影响血液和大脑中聚集型原钙粘蛋白甲基化的新位点 |
Liu, Y. |
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N/A |
Identification of SENP7 and UTF1/VENTX as new loci influencing clusteredprotocadherin methylation across blood and brain using a genome-wide associationstudy |
| 复制压力在整个疟原虫基因组中增加了新生拷贝数变异 |
Brown, N. J. |
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N/A |
Replication stress increases de novo CNVs across the malaria parasite genome |
| 泛基因组结构变异模式反映了甘蓝型油菜的进化多样化 |
Afsharyan, N. P. |
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N/A |
Pangenomic structural variant patterns reflect evolutionary diversification in Brassica napus |
| 在奶牛中进行的基因组范围关联分析强调了与小鼠和人类生育能力以及人类健康特征重叠的基因。 |
Marrella, M. |
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N/A |
Genome-wide association analyses in dairy heifers highlight genes overlapping with mouse and human fertility and human health traits |
| 人类ORC2对表观遗传和染色体结构的调控 |
Su, Z. |
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N/A |
Regulation of epigenetics and chromosome structure by human ORC2 |
| 黄素蛋白作为细胞内电子顺磁共振光谱学的天然和遗传编码自旋探针 |
Chauvire, T. |
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N/A |
Flavoproteins as native and genetically encoded spin probes for in cell ESR spectroscopy |
| 微生理学尿毒症模型揭示了血管功能障碍的生物物理增强因素 |
Rathod, M. |
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N/A |
Microphysiological uremia model reveals biophysical potentiators of vascular dysfunction |
| 通过近红外二区纳米传感器非侵入性地实时监测体内免疫细胞与肿瘤细胞的相互作用 |
Huang, L. |
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N/A |
Noninvasively real-time monitoring in-vivo immune cell and tumor cell interaction by NIR-II nanosensor |
| 细菌驱动的活性材料可促进珊瑚幼虫的定居。 |
Levy, N. |
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N/A |
Bacteria-powered living materials enable coral larval settlement |
| 从复杂陆地生境中恢复高连续性的基因组揭示了超过15,000种新的原核生物物种，并扩展了对土壤和沉积物微生物群落的特征描述。 |
Sereika, M. |
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N/A |
Recovery of highly contiguous genomes from complex terrestrial habitats reveals over 15,000 novel prokaryotic species and expands characterization of soil and sediment microbial communities |
| 在存在未知个体的情况下对个体动物进行声学识别 |
Huang, L. |
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N/A |
Acoustic Recognition of Individual Animals in thePresence of Unknown Individuals |
| 基准测试单细胞RNA测序拷贝数变异检测工具 |
Schmid, K. T. |
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N/A |
Benchmarking scRNA-seq copy number variation callers |
| 一种与量子兼容的经典连续体模型解释了细胞膜及其交联剂的力学响应。 |
Kim, J. |
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N/A |
A quantum compatible classical continuum model explains mechanical responses of cell membranes and membrane crosslinkers |
| 扩展基于氮氧自由基的顺磁探针的多样性，这些探针与非经典氨基酸结合，用于SDSL-EPR应用 |
Bizet, M. |
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N/A |
Expanding the diversity of nitroxide-based paramagnetic probes conjugated to non-canonical amino acids for SDSL-EPR applications |
| 将环境质谱成像与同一癌症组织上的空间转录组学相结合，以识别基因-代谢物相关性 |
Godfrey, T. M. |
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N/A |
Integrating Ambient Mass Spectrometry Imaging and Spatial Transcriptomics on the Same Cancer Tissues to Identify Gene-Metabolite Correlations |
| PRLX-93936 和 BMS-214662 是细胞毒性分子胶，它们利用 TRIM21 来降解核孔蛋白。 |
Scemama de Gialluly, M. A. |
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N/A |
PRLX-93936 and BMS-214662 are cytotoxic molecular glues that leverage TRIM21 to degrade nucleoporins |
| 酮体β-羟基丁酸介导的表观遗传染色质β-羟基丁酰化保护肾脏 |
Mandal, J. |
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N/A |
The ketone body β-Hydroxybutyrate mediated epigenetic chromatin β-hydroxybutyrylation protects kidneys |
| 通过深度强化学习加速伤口愈合：一种数据驱动的最佳治疗方案 |
Lu, F. |
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N/A |
Accelerating Wound Healing Through Deep Reinforcement Learning: A Data-Driven Approach to Optimal Treatment |
| 在人类大脑中通过功能成像跨越空间尺度；在10.5特斯拉场强下的初步经验 |
Vizioli, L. |
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N/A |
Spanning spatial scales with functional imaging in the human brain; initial experiences at 10.5 Tesla |
| 熟练运动技能的自然变异性在自由活动小鼠的大脑皮层中得到了稳定的编码。 |
de Laittre, E. A. |
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N/A |
The natural variability of a dexterous motor skill is stably encoded in the cortex of freely behaving mice |
| 小鼠脑类器官模型能够模拟体内神经发育和功能，并能捕捉到与人类之间的差异。 |
Lancaster, M. A. |
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N/A |
Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human |
| LAG3标记了激活但低反应性的NK细胞。 |
Vasilyeva, V. |
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N/A |
LAG3 marks activated but hyporesponsive NK cells. |
| 在动物中，可移动元件的水平转移更多地受到系统发育相关性的促进，而非水生栖息地。 |
Muller, H. |
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N/A |
Phylogenetic relatedness rather than aquatic habitat fosters horizontal transfer of transposable elements in animals |
| 东非慈鲷V1R受体基因显著多样性中可能涉及的幽灵渗入 |
Taki, S. |
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N/A |
Possible involvement of ghost introgressions in the striking diversity of V1R receptor genes in East African cichlids |
| 基于药效团约束的新药设计与扩散桥接技术 |
Wang, C. |
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N/A |
Pharmacophore-constrained de novo drug design with diffusion bridge |
| 学习使用MSA Transformer进行系统发育的语言 |
Chen, R. |
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N/A |
Learning the Language of Phylogeny with MSA Transformer |
| EpiAgent：单细胞表观基因组数据的基石模型 |
Chen, X. |
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N/A |
EpiAgent: Foundation model for single-cell epigenomic data |
| 通过逐步外显子定义实现协调的可变剪接决策 |
Kristofori, P. |
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N/A |
Coordinated alternative splicing decisions via stepwise exon definition |
| 基于志贺毒素的工程免疫原的冷冻电镜结构，能够引发具有治疗溶血性尿毒综合征潜力的中和抗体。 |
Cristofalo, A. E. |
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N/A |
Cryo-EM structures of engineered Shiga toxin-based immunogens capable of eliciting neutralizing antibodies with therapeutic potential against Hemolytic Uremic Syndrome |
| 一个可靶向的发展程序共同调控血管生成和免疫逃逸 |
Berico, P. |
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N/A |
A targetable developmental program co-regulates angiogenesis and immune evasion |
| 应激驱动的可遗传非遗传性药物抗性出现 |
Xie, J. L. |
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N/A |
Stress-driven emergence of heritable non-genetic drug resistance |
| 推测的细粒棘球绦虫的EGF配体和受体，对寄生虫发育至关重要。 |
Koike, A. |
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N/A |
Putative EGF ligand and receptor of Echinococcus multilocularis that are critical for parasite development |
| 现场监测和液压模型量化了未处理污水作为一条流经大城市的河流中抗药性基因的主要来源。 |
Sonkar, V. |
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N/A |
Field monitoring and hydraulic modelling quantify untreated wastewater as dominant source of AMR in a small river running through a big city |
| 定义高翻译通读终止密码子上下文 |
Smoljanow, D. |
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N/A |
Defining the high-translational readthrough stop codon context |
| 研究相分离蛋白质中的氨基酸富集与模式：理解液-液相分离中的偏倚 |
Calvario, J. |
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N/A |
Investigating Amino acid Enrichments and Patterns in Phase-Separating Proteins: Understanding Biases in Liquid-Liquid Phase Separation |
| ArfGAP ASAP1中的PH结构域通过一种前所未有的别构机制驱动催化激活。 |
Soubias, O. |
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N/A |
The PH domain in the ArfGAP ASAP1 drives catalytic activation through an unprecedented allosteric mechanism |
| 染色质中新DNA甲基化的结构基础 |
Xie, X. |
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N/A |
The structural basis for de novo DNA methylation in chromatin |
| 来自哥伦比亚北部上新世的淡水鱼化石与南美洲北部古地理 |
Ballen, G. A. |
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N/A |
Fossil Freshwater Fishes from the Pliocene of northern Colombia and the Palaeogeography of northern South America |
| 一种参与类胡萝卜素信号传导的细胞色素P450能够增强植物的光合作用能力和光氧化应激耐受性。 |
Tiwari, M. |
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N/A |
A cytochrome P450 involved in apocarotenoid signaling enhances plant photosynthetic capacity and photooxidative stress tolerance |
| 气溶胶沉积影响山毛榉叶的水分吸收和水分流失 |
Koch, I. |
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N/A |
Aerosol deposition affects water uptake and water loss of beech leaves |
| 一种脆弱的多巴胺能神经元亚型在帕金森病的早期运动障碍中起驱动作用 |
Fushiki, A. |
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N/A |
A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson's Disease |
| 在人皮质类器官中，静默突触转化为由AMPA受体介导的功能性突触 |
Nishimura, M. |
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N/A |
Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids |
| 生成音乐模型揭示了音乐专业知识对音乐的解耦和情境神经编码的影响 |
Mischler, G. |
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N/A |
The impact of musical expertise on disentangled and contextual neural encoding of music revealed by generative music models |
| 一种调节性注意门控促进了果蝇的近期记忆表达。 |
Kapoor, I. |
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N/A |
A modulatory attentional gate promotes recent memory expression in Drosophila |
| 一种双特异性T细胞结合抗体在实验性同基因和基因工程改造的胶质母细胞瘤模型中展现出强大的活性、特异性和肿瘤微环境重塑能力。 |
Zannikou, M. Z. |
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N/A |
A Bi-Specific T Cell-Engaging Antibody Shows Potent Activity, Specificity, and Tumor Microenvironment Remodeling in Experimental Syngeneic and Genetically Engineered Models of GBM |
| 免疫细胞与肾细胞之间的时空相互作用决定了自身免疫性肾病中肾小球新月体的形成。 |
Sultana, Z. |
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N/A |
Spatio-temporal interaction of immune and renal cells determines glomerular crescent formation in autoimmune kidney disease |
| MAETi：在尖端进行轻度酸性洗脱，能够从25,000个细胞中实现定量的免疫肽组学分析。 |
Beyrle, J. |
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N/A |
MAETi: Mild acid elution in a tip enables quantitative immunopeptidome profiling from 25,000 cells |
| 益生菌Aliivibrio sp. Vl2株对Moritella viscosa的拮抗机制：基于共培养和转录组分析的证据 |
Steen Dobloug, M. |
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N/A |
Antagonistic mechanisms of probiotic Aliivibrio sp. strain Vl2 against Moritella viscosa: Evidence from co-cultivation and transcriptomic analysis |
| 番茄根际微生物群落对植物促生根际细菌合成群落的时序动态响应 |
Nicotra, D. |
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N/A |
Temporal Dynamics of the Tomato Rhizosphere Microbiome in Response to Synthetic Communities of Plant Growth-Promoting Rhizobacteria |
| 多组织代谢组学揭示了线粒体DNA和饮食特异性代谢物特征在心肌代谢疾病小鼠模型中的表现 |
Shastry, A. |
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N/A |
Multi-Tissue Metabolomics Reveal mtDNA- and Diet-Specific Metabolite Profiles in a Mouse Model of Cardiometabolic Disease |
| ITGB4通过靶向EZR激活Wnt/β-catenin信号通路，从而促进结直肠癌的进展。 |
Wang, J. |
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N/A |
ITGB4 promotes the progression of colorectal cancer by activating Wnt/β-catenin signaling pathway via targeting EZR |
| MSH2在脆性X综合征中FMR1位点的DNA甲基化维持或重复序列收缩过程中并非必需的。 |
Grant-Bier, J. |
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N/A |
MSH2 is not required for either maintenance of DNA methylation or repeat contraction at the FMR1 locus in fragile X syndrome |
| EnsembleFlex：让蛋白质结构集合分析变得简单 |
Schneider, M. |
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N/A |
EnsembleFlex: Protein Structure Ensemble Analysis Made Easy |
| 棕熊在冬眠期间，脂肪组织会激活一种名为胆囊收缩素（CCK）的饱腹感激素通路。 |
Henriksen, T. I. |
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N/A |
Brown Bears activates a Satiety Hormone Cholecystokinin (CCK) pathway in adipose tissue during hibernation |
| 染色质调节因子HELLS介导SSB修复及对DNA烷基化损伤的反应。 |
Joseph, J. T. |
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N/A |
Chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage. |
| 在人类报告iPSC系中，一步全RNA引导编辑系统实现了接近100%的基因编辑效率。 |
Wettschurack, K. |
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N/A |
Near 100% genome editing efficiency with a one-step all RNA prime editing system in a human reporter iPSC line |
| 果蝇和赤拟谷盗之间中线轴突导向活性的进化保守性 |
Ghosh, P. |
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N/A |
Evolutionary conservation of midline axon guidance activity between Drosophila and Tribolium Frazzled |
| 对Sarpagan和Akuammiline生物碱生物合成过程的立体化学洞察 |
Mann, S. G. A. |
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N/A |
Stereochemical Insights into Sarpagan and Akuammiline Alkaloid Biosynthesis |
| 肼苯哒嗪通过抑制胱胺双加氧酶来治疗先兆子痫并促使胶质母细胞瘤衰老。 |
Shishikura, K. |
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N/A |
Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma |
| CYP152过氧化物酶对非羧酸底物的意外活性揭示了新的底物识别机制和催化多功能性。 |
Jiang, Y. |
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N/A |
Unexpected Activities of CYP152 Peroxygenases towards Non-carboxylic Substrates Reveal Novel Substrate Recognition Mechanism and Catalytic Versatility |
| FANCJ DNA解旋酶继续组装G-四链体修复复合物 |
Campbell, L. |
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N/A |
A continuation of the assembly of a G-quadruplex repair complex by the FANCJ DNA helicase |
| 将组蛋白H2B变体整合到染色质中会改变染色质的可及性，从而诱导乳腺癌中的上皮-间质转化。 |
Dhahri, H. |
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N/A |
Incorporating histone H2B variants into chromatin modifies chromatin accessibility to induce epithelial to mesenchymal transition in breast cancer |
| 生物工程酵母锚定的呼吸超级复合物揭示了高效底物利用的调控机制 |
Eldeeb, M. H. |
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N/A |
Bioengineered yeast tethered respiratory supercomplexes reveal mechanisms governing efficient substrate utilization |
| 抗分枝杆菌套索肽Triculamin的趋同进化 |
Merrild, A. |
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N/A |
Convergent Evolution of the Antimycobacterial Lasso Peptide Triculamin |
| 突破交联质谱法的界限：借助Orbitrap Astral质谱分析仪提升通量与灵敏度 |
Mueller, F. |
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N/A |
Breaking Barriers in Crosslinking Mass Spectrometry: Enhanced Throughput and Sensitivity with the Orbitrap Astral Mass Analyzer |
| 双交联？关于甲基球菌细胞色素P460中一种异常交联的血红素的结构和计算研究 |
Pfalzgraf, H. E. |
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N/A |
Double crossed? Structural and computational studies of an unusual crosslinked heme in Methylococcus capsulatus cytochrome P460 |
| 脂质在冷冻电镜条件下调节RyR1的开放概率 |
Li, C. |
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N/A |
Lipids modulate open probability of RyR1 under cryo-EM conditions |
| 噬菌体展示合成文库和纳米抗体筛选平台 |
Xia, B. |
PDF |
N/A |
Phage-displayed synthetic library and screening platform for nanobody discovery |
| SpaceExpress：一种基于组织内在坐标系统的比较空间转录组学方法 |
Kim, Y. |
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N/A |
SpaceExpress: a method for comparative spatial transcriptomics based on intrinsic coordinate systems of tissues |
| 稳定插入缺失突变的结构和能量分析 |
Gutierrez, Y. M. |
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N/A |
Structural and energetic analysis of stabilizing indel mutations |