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BioRxiv 2024-12-22 Papers

标题 作者 PDF链接 代码仓库 Title
通过互信息识别的局部神经可塑性 Scheler, G. PDF N/A Localist Neural Plasticity Identified By Mutual Information
微RNA-19b调控禽类前脑中的增殖与模式形成 Mishra, A. PDF N/A microRNA-19b regulates proliferation & patterning in the avian forebrain
α-突触核蛋白C末端域的构象开关指导其纤维多态性 Aguirre, C. PDF N/A Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs
TET1能够减弱人类多能性相关的异质性,并增强分化能力。 Motono, M. PDF N/A TET1 attenuates human pluripotency-related heterogeneities and enhances differentiation capabilities
通过数百万次实验室检测揭示的孕期和产后动态 Bar, A. PDF N/A Pregnancy and postpartum dynamics revealed by millions of lab tests
对转录的超保守区域进行全面分析,揭示了新型非编码转录本在胶质瘤中的重要调控功能。 Gibert, M. K. PDF N/A A comprehensive analysis of Transcribed Ultra Conserved Regions uncovers important regulatory functions of novel non-coding transcripts in gliomas.
热抑制配子发生可以解释历史上幼体招募的崩溃现象。 Okamoto, D. K. PDF N/A Thermal suppression of gametogenesis can explain historical collapses in larval recruitment
膜脂多不饱和性选择性地影响配体诱导的多巴胺D2受体内吞作用 Sposini, S. PDF N/A Membrane lipid poly-unsaturation selectively affects ligand induced dopamine D2 receptor internalization
通过溶酶体运输开关协调调节激活素和骨形态发生蛋白信号传导 Hom, W. W. PDF N/A Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch
模拟研究了空间在药物敏感和药物耐受癌症细胞相互作用中的作用。 Pugh, K. PDF N/A Simulations probe the role of space in the interplay between drug-sensitive and drug-resistant cancer cells
拯救DNMT1未能完全逆转其在小鼠胚胎干细胞中丧失所引起的分子和功能后果 Elder, E. PDF N/A Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells
CellSeg3D:用于荧光显微镜的自监督3D细胞分割 Achard, C. PDF N/A CellSeg3D: self-supervised 3D cellsegmentation for fluorescence microscopy
水稻盐胁迫响应的系统基因组学 Gupta, S. PDF N/A System genomics of salinity stress response in rice
用于神经科学应用的纳米多孔铂微电极阵列 Winter-Hjelm, N. PDF N/A Nanoporous Platinum Microelectrode Arrays for Neuroscience Applications
分子和空间转录组学分类中脑多巴胺神经元及其在帕金森病LRRK2G2019S模型中的改变 Gaertner, Z. PDF N/A Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease
在动物体内针对特定基因组DNA序列进行靶向诱变,以生成变异库。 Falo-Sanjuan, J. PDF N/A Targeted mutagenesis of specific genomic DNA sequences in animals for the in vivo generation of variant libraries
DNAH12的缺乏会导致雄性不育,因为它会损害DNAH1和DNALI1在人类和小鼠中的招募。 Yang, M. PDF N/A Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice
一种高效预测自然物体感知相似度的高通量方法 Kaniuth, P. PDF N/A A high-throughput approach for the efficient prediction of perceived similarity of natural objects
用于研究人胶质-神经元及大胶质-小胶质相互作用的人-鼠嵌合脑模型 Jin, M. PDF N/A Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial Interactions
改变的B细胞代谢途径特征化1型糖尿病的进展 Conway, H. PDF N/A Altered B Cell Metabolic Pathways Characterize Type 1 Diabetes Progression
微囊藻中标记基因及细胞内无定形碳酸钙生物矿化候选基因的昼夜表达变化 Bruley, A. PDF N/A Diel changes in the expression of a marker gene and candidate genes for intracellular amorphous CaCO3 biomineralization in Microcystis
T细胞在角质形成细胞和真皮成纤维细胞中促进皮肤炎症性疾病的不同转录程序。 DeBerg, H. A. PDF N/A T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts
Hao-Fountain综合征蛋白USP7通过BCOR-ncPRC1.1调控神经分化。 Wolf van der Meer, J. PDF N/A Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1
雷帕霉素减少动脉矿物密度并促进有益的血管重塑在小鼠重度中膜动脉钙化模型中 Behzadi, P. PDF N/A Rapamycin Reduces Arterial Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification
中心纺锤体和Ect2的系统发育学与结构建模为后生动物和多细胞性的出现提供了机制上的见解。 Glotzer, M. PDF N/A Phylogenetics and structural modeling of Centralspindlin and Ect2 provides mechanistic insights into the emergence of Metazoa and multicellularity
RNA聚合酶III中与TFIIE相关的串联双翼螺旋结构的多功能性基础 Wu, J.-S. PDF N/A Structural underpinning of multi-functionality of TFIIE-related tandem-winged-helix in RNA polymerase III
将种内变异整合到种群动态中,揭示了相互作用的物种如何在互利共生群落中持续存在。 Arroyo-Correa, B. PDF N/A Integrating intraspecific variation into population dynamics reveals how interacting species persist in mutualistic communities
毫秒级的运动编码先于鸣禽的感觉运动学习 Pascual, L. M. PDF N/A Millisecond-scale motor coding precedes sensorimotor learning in songbirds
O特异性抗原的丧失影响了铜绿假单胞菌在鼠类临床前肺部感染模型中的微生物地理分布。 Fraser, H. PDF N/A Loss of O-specific antigen shapes Pseudomonas aeruginosa microbiogeography in murine preclinical pulmonary infection model
新发现的鼠CD103-树突状细胞是高免疫原性的常规DC2亚群,对应于已知的小鼠和人类中的树突状细胞亚群。 Sawanobori, Y. PDF N/A Newly found rat CD103- dendritic cells are the highly immunogenic conventional DC2 subpopulation, corresponding to the known DC subsets in mice and humans.
在细菌噬菌体代谢劫持的全基因组模型中的协同作用与拮抗作用 Rozum, J. C. PDF N/A Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophage
Remodelin对小鼠肌细胞分化的抑制作用 Sian, V. PDF N/A The inhibitory effects of Remodelin on murine myoblasts differentiation
一个用于生成多维3D对象并精细控制特征空间的工具箱:Quaddle 2.0 Wen, X. PDF N/A A Toolbox for Generating Multidimensional 3-D Objects with Fine-Controlled Feature Space: Quaddle 2.0
Spatial-DC:一种基于深度学习的稳健方法,用于空间蛋白质组学的反卷积 Li, Y. PDF N/A Spatial-DC: a robust deep learning-based method for deconvolution of spatial proteomics
脑脊液和血浆中apoE糖基化水平的增加与阿尔茨海默病生物标志物水平的降低有关。 Nedelkov, D. PDF N/A Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers
细菌表面上的Hemin结合DNA结构促进了胞外电子传递。 Ajunwa, O. M. PDF N/A Hemin-binding DNA structures on the surface of bacteria promote extracellular electron transfer
混合细胞群体的自发趋化性 Ucar, M. C. PDF N/A Self-generated chemotaxis of mixed cell populations
鲲鹏:一种超内存高效、快速且准确的泛域分类器,适用于所有分类任务 Chen, Q. PDF N/A Kun-peng: an ultra-memory-efficient, fast, and accurate pan-domain taxonomic classifier for all
脑场电位的不规则指数取决于所估计的频率范围。 Boncompte, G. PDF N/A Aperiodic exponent of brain field potentials is dependent on the frequency range it is estimated
用于利用高光谱卫星影像绘制沿海湿地中S. salsa分布的碱蓬高光谱指数(SSHI) zhang, m. PDF N/A Suaeda Salsa Hyperspectral Index (SSHI) for mapping S. salsa in coastal wetlands using hyperspectral satellite imagery
在厄瓜多尔低山热带雨林中蕨类的低度及兼性菌根化 Michel, J. PDF N/A Low and facultative mycorrhization of ferns in a low-montane tropical rainforest in Ecuador
热应激促使六射珊瑚中病毒和抗病毒先天免疫的快速激活 Sharoni, T. PDF N/A Heat stress drives rapid viral and antiviral innate immunity activation in Hexacorallia
通过在近红外IIb窗口放大检测miRNA-21实现早期慢性结肠炎癌变的无创诊断 Zhai, F. PDF N/A Non-invasive diagnosis of early chronic colitis cancerization via amplified sensing of miRNA-21 in NIR-IIb window
ASMS:无需基因分型即可在人类基因组中寻找等位基因特异性甲基化 Raineri, E. PDF N/A ASMS: finding allele specific methylation in human genomes without phasing
纤维化的肺尘灶是在一项为期两年的吸入研究中,由二氧化钛纳米颗粒引起的大鼠晚期尘肺病变。 Yamano, S. PDF N/A Fibrotic pulmonary dust foci is an advanced pneumoconiosis lesion in rats induced by titanium dioxide nanoparticles in a 2-year inhalation study
在肯尼亚农村,教师和看护者在通过游戏促进儿童早期学习和发展的认知与角色。 Otwate, P. W. PDF N/A The perceptions and roles of teachers and caregivers on play in promoting children's early learning and development in rural Kenya
基因调控网络与多组学数据的整合提升了癌症生存预测的准确性 Pop, R. T. PDF N/A Gene regulatory network integration with multi-omics data enhances survival predictions in cancer
可遗传免疫接种为病原体控制建立了一种新模式 Buchthal, J. PDF N/A Heritable Immunization Establishes a New Model for Pathogen Control
氯化多环芳烃的量子化学性质用于delta机器学习 Frolov, D. PDF N/A Quantum chemical properties of chlorinated polycyclic aromatic hydrocarbons for delta machine learning
从弱相互作用到强亲和力:通过核磁共振和计算分析解读链霉亲和素-生物素相互作用 Ptaszek, A. L. PDF N/A From Weak Interactions to Strong Affinity: Deciphering the Streptavidin-Biotin Interaction through NMR and ComputationalAnalysis
一个受生物启发的分层卷积能量模型预测了V4对自然视频的响应 Gallant, J. L. PDF N/A A biologically-inspired hierarchical convolutional energy model predicts V4 responses to natural videos
一线标准治疗药物对杀菌反应、耐药性出现及治愈在小鼠易治或难治性结核病模型中的贡献 Peroutka-Bigus, N. PDF N/A Contribution of front-line, standard of care drugs to bactericidal responses, resistance emergence, and cure in murine models of easy- or hard-to-treat tuberculosis disease
卡尺:用于表型实验和再生研究的细胞周期感知活体成像技术 Di Sante, M. PDF N/A CALIPERS: Cell cycle-aware live imaging for phenotyping experiments and regeneration studies
GeneSetCluster 2.0:一个全面的工具集,用于总结和整合基因集分析 Ortega-Legarreta, A. PDF N/A GeneSetCluster 2.0: a comprehensive toolset for summarizing and integrating gene-sets analysis
TrimNN:表征细胞群落基序,用于研究复杂组织中多细胞拓扑结构 Yu, Y. PDF N/A TrimNN: Characterizing cellular community motifs for studying multicellular topological organization in complex tissues
一种可注射的壳聚糖水凝胶能够在肿瘤内局部定位并可调节地释放免疫治疗药物,从而消除经过治疗和远端效应的小鼠三阴性乳腺癌肿瘤。 Mantooth, S. M. PDF N/A An injectable chitosan hydrogel localizes and tunably releases immunotherapeutics intratumorally eliminating both treated and abscopal murine triple negative breast tumors
补充花卉资源并不能缓解城市化对巢穴筑巢的蜜蜂和黄蜂的负面影响。 Ellis, E. E. PDF N/A Supplementing floral resources does not mitigate the negative effects of urbanisation on cavity-nesting bees and wasps.
突破界限:新记录的分布地及对印度东北部梅加拉亚邦特有物种——卡西山蟾蜍(Bufoides meghalayanus)保护状况的重新评估 Sengupta, S. PDF N/A Breaking Boundaries: New locality records and a reassessment of the conservation status of the Khasi Hill Toad (Bufoides meghalayanus) endemic to Meghalaya, Northeast India
基因调控网络及从头起源基因的关键转录因子 Peng, J. PDF N/A Gene regulatory networks and essential transcription factors for de novo originated genes
在清醒、不受束缚的猫中进行非连续神经调节可增加膀胱容量 Ortiz Lopez, M. PDF N/A Non-continuous neuromodulation in awake, unrestrained felines increases bladder capacity
闭链肩部模型的个性化能够为多种运动提供高精度的运动学准确性。 Hammond, C. V. PDF N/A Personalization of Closed-Chain Shoulder Models Yields High Kinematic Accuracy for Multiple Motions
植物可视化平台:一个综合的基于网络的工具,用于整合、可视化和分析植物及相关物种的组学数据 Santiago, A. PDF N/A The Plantae Visualization Platform: a comprehensive web-based tool for the integration, visualization, and analysis of omic data across plant and related species
植物可视化平台:一个综合的基于网络的工具,用于整合、可视化和分析跨植物及相关物种的组学数据。 Santiago, A. PDF N/A The Plantae Visualization Platform: a comprehensive web-based tool for the integration, visualization, and analysis of omic data across plant and related species
PHACE:基于系统发育的协同进化分析 Kuru, N. PDF N/A PHACE: Phylogeny-Aware Co-Evolution
家谱画家(PePa):一种用于在染色体背景下可视化遗传继承的工具。 Pozzi, A. PDF N/A Pedigree Painter (PePa): a tool for the visualization of genetic inheritance in chromosomal context
家谱画家(PePa):一种用于在染色体背景下可视化遗传继承的工具。 Pozzi, A. PDF N/A Pedigree Painter (PePa): a tool for the visualization of genetic inheritance in chromosomal context
MultiNMRFit:一款用于拟合一维和伪二维核磁共振谱的软件 Millard, P. PDF N/A MultiNMRFit: A software to fit 1D and pseudo-2D NMR spectra
ETV5的T505A变体在急性淋巴细胞白血病的鼠模型中促进前B细胞的增殖。 Yi, J. PDF N/A T505A variant of ETV5 promotes proliferation of precursor B cells in a mouse model of acute lymphoblastic leukemia
利用氧化途径改造酿酒酵母使其能在木糖上生长 Tanaka, K. PDF N/A Engineering Saccharomyces cerevisiae for growth on xylose using an oxidative pathway
学习人类基因组中配对的表观基因组与转录因子结合关联评分 Kwon, S. B. PDF N/A Learning a Pairwise Epigenomic and Transcription Factor Binding Association Score Across the Human Genome
研究牛津纳米孔长读长测序相对于Illumina微阵列和短读长测序的性能 Santos, R. PDF N/A Investigating the performance of Oxford Nanopore long-read sequencing with respect to Illumina microarrays and short-read sequencing
α-突触核蛋白纤维在S129位点的磷酸化改变了DNAJB1的结合,这一现象通过固态核磁共振技术得以探测。 Pacheco, S. PDF N/A Phosphorylation of α-synuclein fibrils at S129 changes DNAJB1 binding as probed by solid-state NMR
骨骼肌干细胞中目标性SMN不足介导了长期的非细胞自主性运动神经元丧失 Mecca, J. PDF N/A Targeted-SMN insufficiency in Skeletal Muscle Stem Cells mediates non-cell autonomous loss of motor neurons at long term
Anxa1+ 多巴胺能神经元的脆弱性定义了帕金森病前驱期的运动迟缓和程序性运动学习障碍。 Mantas, I. PDF N/A Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
P2Y2嘌呤能受体和DNA传感器cGAS共同调控电离辐射介导的促炎性巨噬细胞激活。 Mostefa-Kara, A. PDF N/A P2Y2 purinergic receptor and DNA sensor cGAS dictate ionizing radiation-mediated proinflammatory macrophage activation
SETDB6介导的AuroraB激酶甲基化调控细胞分裂期并保护细胞免受染色体不稳定性。 Feldman, M. PDF N/A AuroraB-kinase methylation by SETD6 regulates cytokinesis and protects cells from chromosomal instability
珍珠驱动线粒体DNA核分布 Landoni, J. C. PDF N/A Pearling Drives Mitochondrial DNA Nucleoid Distribution
使用单细胞qRT-PCR对成年小鼠心脏基质细胞进行转录组分析 Alonaizan, R. PDF N/A Transcriptomic analysis of adult mouse cardiac stromal cells using single-cell qRT-PCR
顺序至关重要:温度的自相关性决定了具有非线性热性能的种群的灭绝风险。 Robey, A. J. PDF N/A Order matters: Autocorrelation of temperature dictates extinction risk in populations with nonlinear thermal performance
拉丁美洲间日疟原虫和辛氏疟原虫宿主转移的基因组学洞察 Lefebvre, M. J. M. PDF N/A Genomic insights into Plasmodium vivax and Plasmodium simium host shifts in Latin America
绘制S. cerevisiae中适应性综合应激反应的遗传架构图 Baum, R. PDF N/A Mapping the Genetic Architecture of the Adaptive Integrated Stress Response in S. cerevisiae
MrHAMER2:高精度长读长RNA测序技术,用于解析病毒转录本在潜伏期中的特定异构体变异 Gallardo, C. M. PDF N/A MrHAMER2: high-accuracy long-read RNA sequencing to decode isoform-specific variation in viral transcripts during latency
多组学基础模型通过零样本预测表观遗传调控 Yang, Z. PDF N/A Multiomic foundation model predicts epigenetic regulation by zero-shot
啮齿动物电子尼古丁输送系统:一种仅限鼻吸入电子烟气溶胶的装置的描述与验证,适用于自由活动的大鼠 Odum, A. L. PDF N/A The Rodent Electronic Nicotine Delivery System: Description and Validationof an Apparatus for Nose-Only E-Cigarette Aerosol Inhalation in Freely Moving Rats
解决方案生物物理学揭示了脂质纳米颗粒的非球形性、多分散性以及其内部有序性对有效mRNA递送的依赖性。 Padilla, M. PDF N/A Solution biophysics identifies lipid nanoparticle non-sphericity, polydispersity, and dependence on internal ordering for efficacious mRNA delivery
OmiGA:一种用于复杂群体中超高效分子性状分析的工具包 Teng, J. PDF N/A OmiGA: A Toolkit for Ultra-efficient Molecular Trait Analysis in Complex Populations
评分信息整合与统计质量控制增强的跨运行分析在数据独立采集蛋白质组学数据中的应用 Gao, M. PDF N/A Scoring Information Integration with Statistical Quality Control Enhanced Cross-Run Analysis of Data-Independent Acquisition Proteomics Data
通过无监督网络嵌入推断果蝇多感官路径的社区结构 Sun, X. PDF N/A Inferring community architectures of multisensory pathways in Drosophila via unsupervised network embedding
使用变分自编码器来表征由于抗生素治疗而产生的异质性亚群 BERSENEV, D. PDF N/A The use of variational autoencoders to characterise the heterogeneous subpopulations that arise due to antibiotic treatment
线粒体珍珠化的生物物理机制 Sturm, G. PDF N/A The biophysical mechanism of mitochondrial pearling
有丝分裂染色体的外周:一种介导染色体力学的流体外套 Mendonca, T. PDF N/A The mitotic chromosome periphery: a fluid coat that mediates chromosome mechanics
在小鼠结肠炎模型中,饮食中铁的剥夺与补充的比较分析 Medjbeur, T. PDF N/A Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis
化学遗传学调控揭示了细胞命运编程的最佳MAPK信号传导 Lende-Dorn, B. A. PDF N/A Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming
经典血清素类致幻剂作用下定向功能层次的崩塌 Vohryzek, J. PDF N/A Collapse of directed functional hierarchy under classical serotonergic psychedelics
应激诱导的内皮细胞线粒体碎片化破坏了血视网膜屏障的完整性,导致神经退行性变。 Cueva Vargas, J. L. PDF N/A Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.
B细胞激活的蛋白质组图谱及其受mTORC1、MYC和铁调控的塑造 James, O. PDF N/A A proteomic map of B cell activation and its shaping by mTORC1, MYC and iron
绘制人类内分泌胰腺在出生后早期各阶段的组织学和功能成熟图谱 Saunders, D. C. PDF N/A Mapping histological and functional maturation of human endocrine pancreas across early postnatal periods
使用扩展谱系模型检测线粒体DNA效应:统计功效与估计偏差的分析 Lyu, X. PDF N/A Detecting mtDNA effects with an Extended Pedigree Model: An Analysis of Statistical Power and Estimation Bias
与果蝇相关的宏基因组组装基因组中的系统发育和功能多样性 Comeault, A. A. PDF N/A Phylogenetic and functional diversity among Drosophila-associated metagenome-assembled genomes
人类基因组中的大型复杂结构重排隐藏着隐秘的结构 Audano, P. A. PDF N/A Large complex structural rearrangements in human genomes harbor cryptic structures
HapCNV:一种用于低输入DNA测序数据CNV检测的综合框架 Yu, X. PDF N/A HapCNV: A Comprehensive Framework for CNV Detection in Low-input DNA Sequencing Data
棘阿米巴卡氏体中亚马逊利什曼原虫的摄取与存活:一种感染生物模型? Geres, L. F. PDF N/A Uptake and survival of Leishmania amazonensis in Acanthamoeba castellanii: An infection organism model?
全球潜在功能性病毒辅助代谢基因的多样性及其与土壤有机碳储量的关系 Merges, D. PDF N/A Global diversity of putative functional viral auxiliary metabolic genes and their relationship with soil organic carbon stocks
病原体在面对先天免疫记忆时的实验进化增加了毒力的变异 Korsa, A. PDF N/A Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence
通过植物标本数据和公民科学数据库揭示的过去几十年中蓝羽扇豆(Lupinus angustifolius)开花时间提前的证据 Jimenez-Lopez, F. J. PDF N/A Evidence of flowering time advance in blue lupin (Lupinus angustifolius) in the last decades revealed by herbarium data and citizen science databases
采蜜黄蜂的陷阱采集行为 Lacombrade, M. PDF N/A Trapline foraging by nectar-collecting hornets
时空光催化邻近标记蛋白质组学揭示配体激活的细胞外和细胞内EGFR邻域 Lin, Z. PDF N/A Spatiotemporal photocatalytic proximity labeling proteomics reveals ligand-activated extracellular and intracellular EGFR neighborhoods
双特异性抗体靶向脂质纳米颗粒 Amabile, A. PDF N/A Bispecific antibody targeting of lipid nanoparticles
使用大型语言模型生成抗原特异性配对的重链和轻链抗体序列 Wasdin, P. T. PDF N/A Generation of antigen-specific paired heavy-light chain antibody sequences using large language models
HMG-DTI:一种结合层次分子图和改进卷积块注意力模块的药物-靶标相互作用预测框架 Yang, Z. PDF N/A HMG-DTI: a drug-target interaction prediction framework combining Hierarchical Molecular Graphs and improved Convolutional Block Attention Module
短的激活域控制转录因子与染色质的结合 Fan, V. PDF N/A Short activation domains control chromatin association of transcription factors
高风险膀胱癌的基因组和转录组分析揭示了多样的分子和微环境生态系统 Methani, K. PDF N/A Genomic and transcriptomic profiling of high-risk bladder cancer reveals diverse molecular and microenvironment ecosystems
高风险膀胱癌的基因组和转录组分析揭示了多样化的分子和微环境生态系统 Meghani, K. PDF N/A Genomic and transcriptomic profiling of high-risk bladder cancer reveals diverse molecular and microenvironment ecosystems
拟南芥EID1 E3泛素连接酶通过调节HSBP的转位来调控获得性耐热性。 Tu, Y.-T. PDF N/A Arabidopsis EID1 E3 ubiquitin ligase regulates acquired thermotolerance by modulating HSBP translocation
同一张幻灯片的空间多组学整合揭示了肿瘤病毒相关的肿瘤微环境空间重组 Yeo, Y. Y. PDF N/A Same-Slide Spatial Multi-Omics Integration Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment
PI3Kγ通路有助于寨卡病毒感染引起的神经炎症和神经元死亡。 Teixeira, D. C. PDF N/A PI3Kγ pathway contributes to neuroinflammation and neuronal death induced by Zika virus infection
新生仔猪和断奶仔猪通过联合口服和鼻内途径接种两种PEDV(S INDEL和非S INDEL)后,先天免疫反应的作用 Lopez-Figueroa, C. PDF N/A The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes
通过回顾性分析美国东北部黑秃鹫不明原因死亡事件中的元基因组测序,发现了一种新型蝙蝠病毒。 Mwakibete, L. PDF N/A Discovery of a novel bandavirus using metagenomic sequencing in a retrospective analysis of an unresolved 2020 mortality event involving black vultures in the northeastern United States.
KIF18A在肝细胞癌转移中的双重作用:抗失巢凋亡和染色体不稳定性 Kan, C. PDF N/A KIF18A in HCC Metastasis: Dual Role in Anoikis Resistance and Chromosome Instability
围产期暴露于纳米聚苯乙烯对炎症性肠病的有害印记 Airaud, M. PDF N/A Deleterious imprinting of perinatal exposure to nano-polystyrene on inflammatory bowel diseases
将裸盖菇素描述为对雄性和雌性大鼠青春期抗抑郁的特性 Garcia-Cabrerizo, R. PDF N/A Characterizing psilocybin as an antidepressant for adolescence in male and female rats
加利福尼亚海狮在人类照料下的眼部疾病流行率:淡水与盐水环境对比 Brehm, I. PDF N/A Ocular Disease Prevalence in California Sea Lions In Human Care: Freshwater Versus Saltwater Housing
CAR-T疗法后免疫抑制微环境的获得导致T细胞功能障碍和耐药性 Ponzo, M. PDF N/A Acquisition of an immunosuppressive microenvironment after CAR-T therapy drives T-cell dysfunction and resistance
通过大规模分析天然配对的人类抗体序列和结构数据,揭示了保守的重/轻链接触和胚系偏好。 Dudzic, P. PDF N/A Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data.
气候变化与人为因素对未来入侵风险的影响对比:一种独居蜂Amegilla pulchra的案例 Dubos, N. PDF N/A Contrasted effect of climate and anthropogenic change on future invasion risk of a solitary bee Amegilla pulchra
释放策略影响养殖场培育的幼年大鳞大麻哈鱼的淡水栖息和生存。 Balfour, T. J. B. PDF N/A Release strategies affect the freshwater residence and survival of hatchery-reared juvenile Chinook Salmon
入侵植物与蜂鸟和花螨网络的整合是由生态适应和泛化驱动的。 Garcia-Robledo, C. PDF N/A Integration of an invasive plant in hummingbird and flower mite networks is driven by ecological fitting and generalization
在珊瑚白化期间,使用RGB颜色指数作为共生体细胞密度和叶绿素含量的代理指标。 Ferrara, E. F. PDF N/A RGB color indices as proxy for symbiont cell density and chlorophyll content during coral bleaching
实验适应性辐射在羽虱隐色现象中的基因组学研究 Baldwin-Brown, J. G. PDF N/A Genomics of experimental adaptive radiation in the cryptic coloration of feather lice
智利巴塔哥尼亚北部地区Eleginops maclovinus的基因组信号中的局部适应性 Claure, C. E. PDF N/A Genomic signals of local adaptation in Eleginops maclovinus from Northern Chilean Patagonia
无约束条件下视频中鸟类头部运动的自动分析 Santos-Lopes, M. PDF N/A Automated Analysis of Bird Head Motion from Videos in Unconstrained Settings
使用CRISPR/Cas9进行单倍型编辑作为治疗NEFL显性负性错义突变的一种方法 Dua, P. H. PDF N/A Haplotype editing with CRISPR/Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL
利用EasyGuide CRISPR系统为大肠杆菌在蔗糖上生长设计适应性等位基因 Barreto, J. A. PDF N/A Engineering Adaptive Alleles for Escherichia coli Growth on Sucrose Using the EasyGuide CRISPR System
希腊白纹伊蚊线粒体基因组多样性与系统发育见解 BALATSOS, G. PDF N/A Mitogenome Diversity and Phylogenetic Insights of Aedes albopictus in Greece
原始方案:开源社区资源,用于低成本病毒基因组测序 Kent, C. PDF N/A PrimalScheme: open-source community resources for low-cost viral genome sequencing
生物制造空间组织化的颞下颌关节纤维软骨组件 Dufour, A. PDF N/A Biofabrication of spatially organized temporo-mandibular fibrocartilage assembloids
创建微生物组模型和谐:在两步厌氧消化器中,将元蛋白质组数据与ADM1da相结合 Hellwig, P. PDF N/A Creating microbiome-model harmony between metaproteomics data and the ADM1da for a two-step anaerobic digester
开发用于芯片上器官应用的柔性3D打印TPU-PVC微流体装置 ABDALKADER, R. K. PDF N/A Development of a flexible 3D printed TPU-PVC microfluidic devices for organ-on-a-chip applications
基因组挖掘算法用于识别相同的重复序列,以开发灵敏且特异性的传染病诊断方法 Rajeswari, K. PDF N/A Genome-mining algorithm to identify identical repetitive sequences for sensitive and specific diagnostic assays for infectious diseases
随机空间主成分分析(RASP):一种用于高分辨率空间转录组数据降维的计算高效方法 Gingerich, I. K. PDF N/A Randomized Spatial PCA (RASP): a computationally efficient method for dimensionality reduction of high-resolution spatial transcriptomics data
Verkko2:将邻近连接数据与长读长De Bruijn图整合,用于高效的端粒到端粒基因组组装、相位确定和支架搭建。 Phillippy, A. M. PDF N/A Verkko2: Integrating proximity ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffolding
CESA:跨物种表位序列分析,用于发现可用于模式生物中磷酸化特异性蛋白质检测的现有抗体 Hu, Y. PDF N/A CESA: Cross-species Epitope Sequence Analysis for discovery of existing antibodies useful for phospho-specific protein detection in model species
HAPP:高精度管道,用于处理深度元条形码数据 Sundh, J. PDF N/A HAPP: High-Accuracy Pipeline for Processing deep metabarcoding data
癌症驱动基因的共本质性网络更好地优先考虑抗癌药物 Lee, K. PDF N/A A Co-essentiality Network of Cancer Driver Genes Better Prioritizes Anticancer Drugs
用于细胞计算机模拟基因扰动的AI模型基准测试 Li, C. PDF N/A Benchmarking AI Models for In Silico Gene Perturbation of Cells
具有更大序列库的高速10重DNA-PAINT技术 Banerjee, A. PDF N/A High-speed 10-plex DNA-PAINT with a larger sequence repertoire
直接观察触发响应型脂酶生物杂合体的组装与功能 Voutyritsa, E. PDF N/A Direct observation of assembly and function of trigger responsive lipase biohybrids
空间转录组学探索神经母细胞瘤原发微环境揭示了新的旁分泌相互作用 Siaw, J. T. PDF N/A Spatial transcriptomics exploration of the primary neuroblastoma microenvironment unveils novel paracrine interactions
使用β放射性配体疗法和4Ig-B7-H3异构体特异性靶向进行抗癌免疫启动 Glazer, S. E. PDF N/A Anti-Cancer Immune Priming with Beta-Radioligand Therapy and Isoform-Selective Targeting of 4Ig-B7-H3
法尼基转移酶抑制剂KO-2806使复发的肿瘤重新对RAS抑制敏感。 Patel, H. V. PDF N/A The farnesyl transferase inhibitor KO-2806 re-sensitizes relapsing tumors to RAS inhibition
白血病通过在新生抗原特异性CD4+ T细胞上强加一种1型调节程序来逃避免疫。 Venkatesh, H. PDF N/A Leukemia escapes immunity by imposing a Type-1 regulatory program on neoantigen-specific CD4+ T cells.
SMAD4突变促使肠道微生物群向促进结直肠癌肿瘤进展的方向转变 Gates, T. J. PDF N/A SMAD4 Mutation Drives Gut Microbiome Shifts Toward Tumor Progression in Colorectal Cancer
DUSP6在转移中被上调,并影响胰腺癌细胞的迁移和代谢。 Tannus Ruckert, M. PDF N/A DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
高强度化疗通过反向电子传递引发心脏毒性 Pinto, C. PDF N/A Intensive Chemotherapy Induces Cardiotoxicity via Reverse Electron Transport
双域植物防御素MtDef5衍生的肽的作用方式及其生物杀菌剂潜力 Kalunke, R. M. PDF N/A Modes of action and bio-fungicide potential of peptides derived from the bi-domain plant defensin MtDef5
在顺铂耐药细胞系中,柠檬酸治疗逆转顺铂耐药性 Chaturvedi, S. PDF N/A Cisplatin resistance reversal with treatment of Citric acid in cisplatin-resistant cell lines
两种神经肽信号传导调控雄性蟋蟀的交配后拒绝行为及生殖系统 Zhu, Z. PDF N/A Two neuropeptide signalings regulate post-mating refusal behavior and reproductive system in male crickets
Septin细胞骨架是一种新发现的调控肠道上皮屏障完整性和黏膜炎症的机制。 Naydenov, N. G. PDF N/A The Septin Cytoskeleton is a Novel Regulator of Intestinal Epithelial Barrier Integrity and Mucosal Inflammation
多组学图谱揭示了细胞毒性表型和与活性氧相关的代谢静止作为CTL抵抗的HIV感染CD4+ T细胞的关键特征。 Herrera, A. PDF N/A Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells
发现一种新型结合模式和作用机制的高效选择性人类NLRP3抑制剂 Wilhelmsen, K. PDF N/A Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action
胸腺退化作为一种适应性策略,用于对抗多种病原体。 Iwasa, Y. PDF N/A Thymic involution as an adaptive schedule for combating diverse pathogens.
菌株水平的抗原变异有助于Bacteroides thetaiotaomicron的免疫逃避。 Glowacki, R. W. P. PDF N/A Strain-level antigen variation facilitates immune evasion in Bacteroides thetaiotaomicron
SOD1 控制中性粒细胞的氧化爆发和微生物杀灭。 Foti, A. PDF N/A SOD1 controls neutrophil oxidative burst and microbial killing
在小鼠巨噬细胞中,不同微环境下的性别二态性基因调控 McGill, C. J. PDF N/A Sex-dimorphic gene regulation in murine macrophages across niches
Ilastik:一个用于跨多个脊椎动物物种探究干细胞命运决定的机器学习图像分析平台 Zuniga Munoz, A. PDF N/A Ilastik: a machine learning image analysis platform to interrogate stem cell fate decisions across multiple vertebrate species
通过玻璃化方法测试各种冷冻保护剂组合用于人体皮肤冷冻保存 Riabinin, A. PDF N/A Testing various combinations of cryoprotective agents for human skin cryopreservation by vitrification method
整合捕食者的能量平衡、冒险行为和微生境于功能反应中:解开多物种脊椎动物群落中的间接相互作用 Beardsell, A. PDF N/A Integrating predator energetic balance, risk-taking behavior and microhabitat in functional response: Untangling indirect interactions in a multispecies vertebrate community
STAT5B白血病突变,改变SH2酪氨酸665,对免疫基因程序产生相反的影响。 Lee, H. K. PDF N/A STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs
转录调控位点塑造拟南芥基因表达可塑性的自然变异 Lensink, M. E. PDF N/A Trans-regulatory loci shape natural variation of gene expression plasticity in Arabidopsis
遗传学分析表明,绿蝇(Lucilia cuprina)的幼虫和成虫阶段使用不同的感觉系统。 Wulff, J. P. PDF N/A Genetic analyses suggest that larval and adult stages of Lucilia cuprina employ different sensory systems
SenSet是一种新型的人类肺衰老细胞基因特征,能够识别细胞特异性的衰老机制。 Hasanaj, E. PDF N/A SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms
在社区范围内多次治疗后蛔虫的分子流行病学:谁感染了谁? Landeryou, T. PDF N/A Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment: who infects whom?
一种用于热带爪蟾(Xenopus tropicalis)的表观遗传时钟揭示了与年龄相关的位点,这些位点在H4K20me3标记的异染色质中富集。 Bennett, R. PDF N/A An epigenetic clock for Xenopus tropicalis reveals age-associated sites enriched in H4K20me3-marked heterochromatin
结构解析ADAM17-iRhom2复合物的激活与抑制机制 Maciag, J. J. PDF N/A Structural Insights into the Activation and Inhibition of the ADAM17-iRhom2 Complex
液态与气态阳极零间隙生物电解池的对比研究 Rohbohm, N. PDF N/A A comparison study between liquid- and vapor-fed anode zero-gap bioelectrolysis cells
扩展毛细管工具箱:3D打印的微流体相导管和自聚合模块 Craig, C. PDF N/A Expanding the capillarics toolbox: 3D-printed microfluidic phaseguides and self-coalescence modules
生物医学应用中的Xolography技术:双色光片打印水凝胶,实现形状和硬度的局部控制 Stoecker, L. PDF N/A Xolography for Biomedical Applications: Dual-color Light-sheet Printing of Hydrogels with Local Control over Shape and Stiffness
蛋白质CREATE实现了从头合成蛋白质结合剂的闭环设计。 Lourenco, A. L. PDF N/A Protein CREATE enables closed-loop design of de novo synthetic protein binders
异源表达梭菌属的二氧化碳脱氢酶基因以增强醋酸和酒精从二氧化碳中的生产 Tharak, A. PDF N/A Heterologous Expression of the carbon monoxide dehydrogenase Gene from Clostridium sp. to Enhance Acetic Acid and Alcohol Production from CO2
用于实时成像、手术引导及脑肿瘤复发监测的超声声学肿瘤涂料 Rabut, C. PDF N/A Acoustic tumor paint for real-time imaging, surgical guidance and recurrence monitoring of brain tumors with ultrasound
MRS-Sim:用于模拟类似体内真实磁共振波谱数据的开放源代码框架 LaMaster, J. T. PDF N/A MRS-Sim: Open-Source Framework for Simulating Realistic In Vivo-like MR Spectroscopy Data
独特的细胞核与细胞质转录组特征揭示,仅靠转录本身不足以决定葡萄糖诱导的转录组动态变化 Bagheri, A. PDF N/A Distinct Nuclear and Cytoplasmic Transcriptomic Signatures Reveal Transcription Alone Is Insufficient to Determine Glucose-Induced Transcriptomic Dynamics
"All of Us研究计划"队列中的遗传祖先和人群结构 Sharma, S. PDF N/A Genetic ancestry and population structure in the All of Us Research Program cohort
singIST:一种综合方法,用于比较疾病模型与人类之间的单细胞转录组学 Moruno-Cuenca, A. PDF N/A singIST: an integrative method for comparative single-cell trancriptomics between disease models and humans
Unicore通过结构核心基因实现了可扩展且准确的系统发育重建。 Kim, D. PDF N/A Unicore enables scalable and accurate phylogenetic reconstruction with structural core genes
一种桥联增强型荧光染料的调色板 Zhang, J. PDF N/A A Palette of Bridged Bicycle-Strengthened Fluorophores
细胞突触和扩散运输在形态发生素梯度建立中的作用 Stotsky, J. PDF N/A The Role of Cytonemes and Diffusive Transport in the Establishment of Morphogen Gradients
保持GABAA受体关闭所需的单个主链氢键 Borghese, C. M. PDF N/A A single main-chain hydrogen bond required to keep GABAA receptors closed
利用埃精度冷冻光镜解析PIEZO1的结构构象 Mazal, H. PDF N/A Cryogenic light microscopy with Angstrom precision deciphers structural conformations of PIEZO1
隐式建模构象景观和序列可以用于评估和生成稳定的蛋白质 Cho, Y. PDF N/A Implicit modeling of the conformational landscape and sequence allows scoring and generation of stable proteins
磁性粒子成像的进展:评估磁性微球和优化采集参数以实现高灵敏度细胞追踪 Flood, S. N. PDF N/A Advances in magnetic particle imaging: evaluating magnetic microspheres and optimized acquisition parameters for high sensitivity cell tracking
通过直接跨膜相互作用量化模拟双层膜中的酰基链交错程度 Chaisson, E. H. PDF N/A QUANTIFYING ACYL CHAIN INTERDIGITATION IN SIMULATED BILAYERS VIA DIRECT TRANSBILAYER INTERACTIONS
细胞色素“纳米线”在物理上被限制在亚皮安电流范围内,这足以满足细胞呼吸的需求。 Guberman-Pfeffer, M. J. PDF N/A Cytochrome 'Nanowires' are Physically Limited to Sub-Picoamp Currents that Suffice for Cellular Respiration
抗血管生成肽VIAN-c4551通过降低肺血管通透性,在小鼠中抑制了肺黑色素瘤的转移。 Perez, A. L. PDF N/A The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability
联合抑制SHP2可克服高级别胶质瘤中由BRAF V600E驱动的对1型BRAF抑制剂的适应性抗药性 Ayanlaja, A. A. PDF N/A Combined inhibition of SHP2 overcomes adaptive resistance to type 1 BRAF inhibitors in BRAF V600E-driven high-grade glioma
Parp7产生一种ADP-核糖基降解子,控制雄激素信号的负反馈。 Wierbilowicz, K. PDF N/A Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling
一种用于物种无关整合癌细胞状态的深度学习工具 Rub, J. PDF N/A A deep-learning tool for species-agnostic integration of cancer cell states
NHE1交换子在铜(II)配合物及菲咯啉衍生物的抗癌效应中的作用 Munoz Garzon, K. S. PDF N/A Role of the NHE1 exchanger in the antitumor effects of copper(II) complexes and phenanthroline derivatives
翻译启动代表了急性髓性白血病细胞的一个脆弱点,可以与BCL-2抑制剂联合靶向。 Lee, Y. S. PDF N/A Translation Initiation Represents an Acute Myeloid Leukemia Cell Vulnerability That Can Be Co-Targeted With BCL-2 Inhibition
LINC00599通过与G3BP1和MYH9发生液-液相分离(LLPS)促进肺动脉高压 Wang, Y. PDF N/A LINC00599 Promotes Pulmonary Hypertension via LLPS with G3BP1 and MYH9
蛋白质聚集捕获辅助的硫醇氧化还原蛋白质组学分析 Martinez-Val, A. PDF N/A Protein aggregation capture assisted profiling of the thiol redox proteome
肠道微生物群介导的药物代谢的计算分析 Chum, S. PDF N/A Computational Analysis of the Gut Microbiota-Mediated Drug Metabolism
通过单细胞RNA测序确定抗TCR单克隆抗体的基因组特异性 Magill, I. PDF N/A Genomic Specificity of Anti-TCR mAbs determined by single-cell RNAseq
临床CAR-T的磷酸酪氨酸信号分析揭示了与治疗效果相关的持续信号传导 Yao, B. PDF N/A Phosphotyrosine Signal Profiling of Clinical CAR-T Reveals Tonic Signaling Associated with Therapeutic Efficacy
髓源性抑制细胞减轻牙周疾病的炎症 Naqvi, R. PDF N/A Myeloid-derived Suppressor Cells Mitigate Inflammation in Periodontal Disease
tRNA修饰酶MnmE和MnmG对于恶性疟原虫的顶质体维持是必不可少的。 Elahi, R. PDF N/A tRNA modifying enzymes MnmE and MnmG are essential for Plasmodium falciparum apicoplast maintenance
与截短型肌联蛋白(ttn.2)变异相关的心肌和骨骼肌功能障碍的部位依赖性差异 Hinits, Y. PDF N/A Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (ttn.2) Variants
顺铂诱导的肾损伤中的IQGAP1-Claudin细胞连接轴 Barudi, Y. PDF N/A The IQGAP1-Claudin Cell Junction Axis in Cisplatin-induced Kidney Damage
探究空间能力多个领域对STEM教育成果的具体预测能力 Zhou, Q. PDF N/A Exploring the specific predictive ability of multiple domains of spatial ability on STEM educational outcomes
对数千种鸟类物种的骨骼特征进行测量 Weeks, B. C. PDF N/A Skeletal trait measurements for thousands of bird species
多聚谷氨酰胺扩展引发的雄激素受体动态错误折叠 Heling, L. W. H. J. PDF N/A Polyglutamine expansion induced dynamic misfolding of Androgen Receptor
长期定殖动态:益生菌Aliivibrio spp.在大西洋鲑鱼(Salmo salar)体内的定殖情况,经浸泡处理后 Steen Dobloug, M. PDF N/A Long-Term Colonization Dynamics of Probiotic Aliivibrio spp. in Atlantic Salmon (Salmo salar) Following Bath Administration
短跑间歇运动会破坏线粒体超微结构,从而在人体中引发一种独特的线粒体应激反应和重塑过程。 Botella, J. PDF N/A Sprint interval exercise disrupts mitochondrial ultrastructure driving a unique mitochondrial stress response and remodelling in humans