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BioRxiv 2024-12-23 Papers

标题 作者 PDF链接 代码仓库 Title
深度学习揭示了细胞如何在类似组织的复杂环境中进行牵引、弯曲和导航。 Padhi, A. PDF N/A Deep Learning Reveals How Cells Pull, Buckle, and Navigate Tissue-Like Environments
一个新的dynamin超家族成员调节布鲁氏锥虫线粒体膜分支 Morel, C. A. PDF N/A A member of a new dynamin superfamily modulates mitochondrial membrane branching in Trypanosoma brucei
在一种海洋蜗牛中,在物种形成连续体的两个不同点上,平行生态型之间的表型差异和基因组结构 Raffini, F. PDF N/A Phenotypic divergence and genomic architecture between parallel ecotypes at two different points on the speciation continuum in a marine snail
CDK8/19抑制剂减轻了BCR-ABL拮抗剂引起的G1期阻滞,并加速了慢性髓性白血病细胞的死亡。 Khamidullina, A. I. PDF N/A CDK8/19 Inhibition Attenuates G1 Arrest Induced by BCR-ABL Antagonists and Accelerates Death of Chronic Myelogenous Leukemia Cells
通过具有引流静脉抑制的依赖层级的fMRI技术,在3T磁共振成像系统下实现全脑范围内特定层级的功能连接映射。 Chang, W.-T. PDF N/A Enabling brain-wide mapping of layer-specific functional connectivity at 3T via layer-dependent fMRI with draining-vein suppression
人类肺组织中SARS-CoV-2感染消退的免疫特征 Kenney, D. J. PDF N/A Immune Signatures of SARS-CoV-2 Infection Resolution in Human Lung Tissues
白喉素介导的呼吸氧化酶灵活性控制结核分枝杆菌的毒力 Buglino, J. PDF N/A Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence
嗜睡症T细胞的多组学分析:与T细胞增殖相关的solo-WCGW基序的全局低甲基化 Shimada, M. PDF N/A Multiomics analysis of narcolepsy T cells: global hypomethylation in solo-WCGW motif linked to T cell proliferation
极小的背景噪音有助于神经语音追踪:随机共振的证据 Herrmann, B. PDF N/A Minimal background noise enhances neural speech tracking: Evidence of stochastic resonance
青春期遭受同伴欺凌会改变基因表达和细胞因子特征,影响向成年期的过渡。 Heumann, J. PDF N/A Peer victimization in adolescence alters gene expression and cytokine profiles during transition to adulthood
特定的前浆细胞状态和暗区-髓质界面处的局部增殖特征了淋巴结生发中心来源的浆细胞分化。 Binet, L. PDF N/A Specific pre-plasma cell states and local proliferation at the dark zone - medulla interface characterize germinal center-derived plasma cell differentiation in lymph node
果蝇翅膀上性选择的目标 De Lisle, S. P. PDF N/A Targets of sexual selection on the Drosophila wing
不对称基因流动维持了海洋无脊椎动物的分布边缘。 Hancock, Z. B. PDF N/A Asymmetric gene flow maintains range edges in a marine invertebrate
对微生物物种树重建的系统发育基因组学方法进行系统评估 Weiner, S. PDF N/A A systematic assessment of phylogenomic approaches for microbial species tree reconstruction
撤回:涉及EDN3的两个不同的结构变异导致鸡的色素沉着过度 Ma, C. PDF N/A WITHDRAWN: Two distinct structural variants involving EDN3 cause hyperpigmentation in chicken
在ADAMTS13缺乏的情况下,微血栓的形成通过黏膜和内皮功能障碍加剧了溃疡性结肠炎。 Tatsuta, K. PDF N/A Microthrombi-growth in ADAMTS13 deficiency exacerbated ulcerative colitis via mucosal and endothelial dysfunction
恢复阿尔茨海默病中的振荡动力学:一种关于血清素类迷幻药物效应的层级全脑模型 Gendra, J. C. PDF N/A Restoring Oscillatory Dynamics in Alzheimer's Disease: A Laminar Whole-Brain Model of Serotonergic Psychedelic Effects
卡西尼:用于RNA和蛋白质原位分析的简化和可扩展方法 Lapique, N. PDF N/A Cassini: Streamlined and Scalable Method for in situ profiling of RNA and Protein
使用单细胞qRT-PCR对成年小鼠心脏基质细胞进行的转录组分析 Alonaizan, R. PDF N/A Transcriptomic analysis of adult mouse cardiac stromal cells using single-cell qRT-PCR
病原体在面对先天免疫记忆时的实验进化增加了毒力的变异 Korsa, A. PDF N/A Experimental evolution of a pathogen confronted with innate immune memory increases variation in virulence
通过大规模分析天然配对的人类抗体序列和结构数据,揭示了保守的重/轻链接触和胚系偏好。 Dudzic, P. PDF N/A Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data.
多组学图谱揭示了细胞毒性表型和与活性氧相关的代谢静止作为CTL耐受的HIV感染CD4+ T细胞的关键特征。 Herrera, A. PDF N/A Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells
在社区范围内多次治疗后蛔虫的分子流行病学:谁感染了谁? Landeryou, T. PDF N/A Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment: who infects whom?
与截短型肌联蛋白(ttn.2)变异相关的心肌和骨骼肌功能障碍的部位依赖性差异 Santiago, C. F. PDF N/A Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (ttn.2) Variants
一种进化上保守的色氨酸笼促进了hnRNPR样蛋白家族中延伸的RNA识别基序的折叠。 Atsrim, E. S. PDF N/A An evolutionarily conserved tryptophan cage promotes folding of the extended RNA recognition motif in the hnRNPR-like protein family
抗有丝分裂化疗促进了三阴性乳腺癌中肿瘤NF-kB分泌表型和免疫抑制性CXCR2+中性粒细胞的趋化作用。 Chocteau, F. PDF N/A Antimitotic chemotherapy promotes tumor NF-kB secretory phenotype and immunosuppressive CXCR2+ neutrophils chemotaxis in triple-negative breast cancers
利用源自患者的混合搭配前脑组合体识别人类精神分裂症中的神经元-胶质信号反馈 Kim, E. PDF N/A Identification of neuron-glia signaling feedback in human schizophrenia using patient-derived, mix-and-match forebrain assembloids
感觉预期在运动回路中塑造神经群体动力学 Michaels, J. A. PDF N/A Sensory expectations shape neural population dynamics in motor circuits
用于体内多重成像的红移GRAB乙酰胆碱传感器 Xie, S. PDF N/A Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo
线粒体分裂与融合对神经元健康及痴呆发病率的影响 Davies, A. M. PDF N/A Impact of mitochondrial fission and fusion onneuronal health and incidence of dementia
非本地植物对本地植物的支配优势随着全球变化因素数量的增加而增强。 Shi, X. PDF N/A The dominance of non-native plants over native plants increases with the number of global change factors
墨西哥脂鲤(Astyanax mexicanus)表层鱼和洞穴鱼性腺中性调控基因的差异表达 Webster, K. A. PDF N/A Differential expression of sex regulatory genes in gonads of Astyanax mexicanus surface fish and cavefish
蜜蜂社交性个体差异的分子分析 Traniello, I. M. PDF N/A Molecular analyses of individual variation in honey bee sociability
化学蛋白质组学鉴定单酰甘油脂类的蛋白质配体 Shanbhag, K. PDF N/A Chemical Proteomics Identifies Protein Ligands for Monoacylglycerol Lipids
HYDRA:用于高通量药物测试的机器人自动化水凝胶分配系统 Torchia, E. PDF N/A HYDRA: HYdrogel Dispensing with Robotic Automation for high throughput drug testing
卡巴苏拉库迪尼尔·乔尔纳姆(Kabasura Kudineer Choornam),一种多草药制剂,能够调节人体巨噬细胞的极化及吞噬功能。 Korkmaz, A. PDF N/A Kabasura Kudineer Choornam, a medicinal polyherbal formulation, modulates human macrophage polarization and phagocytic function
基质晶格的结构成熟并非HIV-1颗粒感染性所必需的。 Chen, L. PDF N/A Structural maturation of the matrix lattice is not required for HIV-1 particle infectivity
一种受信号传导启发的合成工具包,用于高效生产酪氨酸磷酸化蛋白质 Ryan, M. M. PDF N/A A signaling inspired synthetic toolkit for efficient production of tyrosine phosphorylated proteins
限制Ku向内转运封顶端粒末端 Mattarocci, S. PDF N/A Restriction on Ku's Inward Translocation Caps Telomere Ends
环状肌动蛋白-肌球蛋白束驱动内皮细胞变形,以收缩血管。 Chen, Y. PDF N/A Circumferential actomyosin bundles drive endothelial cell deformations to constrict blood vessels
Fbxo42促进Ataxin-2颗粒的降解,从而触发终末Xbp1信号传导。 Santos, C. C. PDF N/A Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling
探索mScarlet在开发用于钙成像的红光寿命传感器中的应用 van der Linden, F. H. PDF N/A Exploration of mScarlet for development of a red lifetime sensor for calcium imaging
条纹獴能够辨别陌生同种个体之间的亲缘关系和主要组织相容性复合体(MHC)的多样性。 Schubert, N. PDF N/A Banded mongooses discriminate relatedness and MHC diversity in unfamiliar conspecifics
自然界中的非典型细胞色素P450酶 Nguy, A. K. L. PDF N/A Non-Canonical Cytochrome P450 Enzymes in Nature
裸露DNA发夹结构中的A-T Hoogsteen碱基对:一种蛋白质识别的构象 Guseva, S. PDF N/A An A-T Hoogsteen base pair in a naked DNA hairpin motif: A Protein-Recognized Conformation
癌症组蛋白突变影响结合和DNA修复过程,导致突变率增加 Espiritu, D. PDF N/A Cancer Histone Mutations Impact Binding and DNA Repair Processes, Leading to Increased Mutagenesis
阿根廷B族链球菌的基因组特征:对噬菌体多样性、毒力因子及抗生素抗性基因的洞察 Kovacec, V. PDF N/A Genomic Characterisation of Group B Streptococcus from Argentina: Insights into Prophage Diversity, Virulence Factors and Antibiotic Resistance Genes
人类参考图谱知识图谱的构建、部署与关联开放数据应用 Bueckle, A. D. PDF N/A Construction, Deployment, and Usage of the Human Reference Atlas Knowledge Graph for Linked Open Data
BenchXAI:在多模态生物医学数据上对事后可解释AI方法的综合基准测试 Metsch, J. PDF N/A BenchXAI: Comprehensive Benchmarking of Post-hoc Explainable AI Methods on Multi-Modal Biomedical Data
ScPectral: 通过光谱聚类转录网络的超图表示来识别发育路径 BERSENEV, D. PDF N/A ScPectral: Spectrally Clustering HypergraphRepresentations of Transcription Networks to Identify Developmental Pathways
KIDINS220和肌醇焦磷酸对人类磷酸盐出口蛋白XPR1的协同激活 Zuo, P. PDF N/A Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate
FAK信号在Rac1驱动的黑色素瘤细胞对MAPK通路抑制的抗性中起着关键作用。 Riordan, J. D. PDF N/A A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
用于在小鼠睾丸生殖细胞中通过碱性彗星试验评估体内DNA损伤水平的协议 Olsen, A.-K. PDF N/A Protocol for assessing DNA damage levels in vivo in rodent testicular germ cells in the Alkaline Comet Assay
胆汁酸与重度抑郁症患者执行控制网络和默认模式网络连接性的关联 Dunlop, B. PDF N/A Association of Bile Acids with Connectivity of Executive Control and Default Mode Networks in Patients with Major Depression
利用设计的远红光多巴胺传感器实现活体内动态神经化学网络的多重成像 Zheng, Y. PDF N/A In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors
FGF21类似物PF-05231023对伏隔核中酒精摄入量和神经元活动的影响 Cooley, B. J. PDF N/A FGF21 Analogue PF-05231023 on Alcohol Consumption and Neuronal Activity in the Nucleus Accumbens
穿越迷宫:识别从fMRI脑模式进行注意力状态分类中的潜在陷阱 Bressler, R. A. PDF N/A Navigating the Maze: Identifying Potential Pitfalls in Attention State Classification from fMRI Brain Patterns
加拿大盾地双温湖中细胞相关病毒群落的组成及其功能潜力 Collis, C. C. PDF N/A Cell-associated viral community composition and its functional potential in a dimictic lake on the Canadian Shield
空间有序的合子基因组激活实现了胚胎质量控制。 Qian, W. PDF N/A Spatially ordered zygotic genome activation fulfills embryo quality control
澳大利亚的黑狐蝠携带新型伯氏疏螺旋体谱系,这些谱系与可传给人的分支相邻。 Verrett, T. B. PDF N/A Black flying foxes in Australia harbor novel Borrelia lineages adjacent to zoonotic clades
RNA-SeqEZPZ:一个点击式管道,用于综合转录组学分析与交互式可视化 Taslim, C. R. PDF N/A RNA-SeqEZPZ: A Point-and-Click Pipeline for Comprehensive Transcriptomics Analysis with Interactive Visualizations
用于生产取代的2-喹诺酮和(硫代)香豆素的生物催化平台 Sokolova, N. PDF N/A A biocatalytic platform for the production of substituted 2-quinolones and (thio)coumarins
StripePy:快速且稳健的建筑条纹表征 Raffo, A. PDF N/A StripePy: fast and robust characterization of architectural stripes
在类原肠胚中,形态发生和转录程序在时间上的解耦依赖于尺寸 Bennabi, I. PDF N/A Size-dependent temporal decoupling of morphogenesis and transcriptional programs in gastruloids
稀疏神经网络能够实现低功耗、可植入的神经接口。 Costello, J. T. PDF N/A Sparse neural networks enable low-power, implantable neural interfaces
人类肺部通用单细胞转录组图谱解码多种肺部疾病 Wu, F. PDF N/A A universal single-cell transcriptomics atlas of human lung decodes multiple pulmonary diseases
开发一种新型外周作用的α2A-肾上腺素受体拮抗剂用于抗糖尿病治疗 Hong, F. PDF N/A Development of a novel peripherally acting alpha2A-adrenergic receptor antagonist for anti-diabetic
一种自由可访问、可调整的中空纤维装置,用于再现一级吸收:以利奈唑胺脑脊液药代动力学数据为例说明 Prebonnaud, N. PDF N/A A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data
急性缺血期间,复极化-舒张耦联的紊乱允许收缩期机械-心律失常的发生。 Cameron, B. A. PDF N/A Disturbed repolarisation-relaxation coupling during acute ischaemia permits systolic mechano-arrhythmogenesis.
肿瘤相关巨噬细胞增强肿瘤神经支配及脊髓修复 Dolci, S. PDF N/A Tumor-associated macrophages enhance tumor innervation and spinal cord repair
ampD突变导致Chromobacterium violaceum中超量产生AmpC和CphA β-内酰胺酶,并对其β-内酰胺类抗生素产生高耐药性。 Laranjeiro, L. G. PDF N/A Mutations in ampD cause hyperproduction of AmpC and CphA beta-lactamases and high resistance to beta-lactam antibiotics in Chromobacterium violaceum
病原性减弱型鼠衣原体突变株在生殖道中的传染性 Li, C. PDF N/A Infectivity of a pathogenicity-attenuated Chlamydia muridarum mutant in the genital tract
一种分泌的蠕虫微小RNA抑制了胃肠道细胞分化,而这种分化是先天免疫所必需的。 Perez, M. G. PDF N/A A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity
单细胞和空间基因组学健康与疾病中人类皮肤成纤维细胞图谱 Steele, L. PDF N/A A single cell and spatial genomics atlas of human skin fibroblasts in health and disease
在静止期阻滞期间,动态的p21依赖性通过一种快速p21耗竭系统得以揭示 Liang, H. PDF N/A Dynamic p21-dependency during quiescence arrest unveiled by a rapid p21 depletion system
使用新型荧光标记的长链脂肪酸类似物检测白细胞中的甘油三酯代谢 Hara, Y. PDF N/A Detection of triglyceride metabolism in white blood cells using a novel fluorescently labeled long chain fatty acid analogue
BMI1介导的异染色质化通过抑制G四链体DNA的形成,在复制过程中维持基因组的稳定性。 Hanna, R. PDF N/A BMI1-mediated heterochromatinization represses G-quadruplex DNA formation to maintain genomic stability during replication
DMD-3对秀丽隐杆线虫雄性尾部顶端形态发生的转录调控 Fernandez, P. PDF N/A Transcriptional control of C. elegans male tail tip morphogenesis by DMD-3
赤道几内亚比奥科岛上的疟疾寄生虫恶性疟原虫定期输入,阻碍了该岛疟疾的消除。 Stabler, T. C. PDF N/A Regular Plasmodium falciparum importation onto Bioko Island, Equatorial Guinea, hampers malaria elimination from the island
近端小管特异性缺失二肽基肽酶4对血压、肾钠处理及NHE3磷酸化的影响 Martins, F. L. PDF N/A Impact of Proximal Tubule-Specific Deletion of Dipeptidyl Peptidase 4 on Blood Pressure, Renal Sodium Handling, and NHE3 Phosphorylation
结肠是一个胰腺外的胰高血糖素来源:在胰切除术小鼠模型中的证明 Jarry, A.-C. PDF N/A The colon is an extra-pancreatic source of glucagon: demonstration in a mouse model of pancreatectomy
益生菌酿酒酵母(Saccharomyces boulardii)中用于肠道脱落酸生产的多步途径工程 Van Gaever, F. PDF N/A Multi-Step Pathway Engineering in Probiotic Saccharomyces boulardii for Abscisic Acid Production in the Gut
多巴胺能调节对纹状体中型多棘神经元亚型状态转换的影响——一项计算研究 Anisetty, N. PDF N/A Impact of dopaminergic modulation on the state transitions of striatal medium spiny neuron sub-types - a computational study
性失败通过多巴胺能信号传导降低雄性果蝇对甜味的感知 Wang, G. PDF N/A Sexual Failure Decreases Sweet Taste Perception in Male Drosophila via Dopaminergic Signaling
作为基本逻辑运算符的工程生物神经网络 Küchler, J. PDF N/A Engineered biological neural networks as basic logic operators
使用大规模机器学习预测低级别胶质瘤患者对替莫唑胺的反应 Du, H. PDF N/A Predicting temozolomide response in low-grade glioma patients with large-scale machine learning
转录组学揭示了人类细胞系中经典和非经典热休克诱导通路 Reinschmidt, A. PDF N/A Transcriptomics Unveil Canonical and Non-Canonical Heat Shock-Induced Pathways in Human Cell Lines
MEANtools:面向代谢物预测和生物合成途径预测的多组学整合工具 Singh, K. S. PDF N/A MEANtools: multi-omics integration towards metabolite anticipation and biosynthetic pathway prediction
形状约束的、含变点的加性模型用于时间序列组学数据的cpam Yates, L. A. PDF N/A Shape-constrained, changepoint additive models for time series omics data with cpam
IFNα 抑制 JAK2V617F 驱动的恶性血管生成和内皮细胞向间充质细胞的转变,基于三维 iPSC 的骨髓微环境模型 Caduc, M. J. PDF N/A IFNα Inhibits JAK2V617F-Driven Neoplastic Vasculogenesis and Endothelial-to-Mesenchymal Transition in a 3D iPSC-Based Bone Marrow Niche Model
具有不同轴突连接的皮层投射神经元采用具有不同蛋白质组成的核糖体复合物。 Tran, T. P. PDF N/A Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions
具有不同轴突连接的皮层投射神经元使用具有不同蛋白质组成的核糖体复合物。 Tran, T. P. PDF N/A Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions
促进聚集的序列而非磷酸化对于Tau蛋白在果蝇中介导的毒性至关重要。 Cooper, A. PDF N/A Aggregation promoting sequences rather than phosphorylation are essential for Tau-mediated toxicity in Drosophila
平衡术:自发言语中连贯性与创造性之间的神经权衡 Patel, T. PDF N/A Balancing Act: A Neural Trade-Off Between Coherence and Creativity in Spontaneous Speech
甲氧西林耐药金黄色葡萄球菌对二线/末线抗生素体外耐药选择特征研究 Prasetyoputri, A. PDF N/A Characterisation of in vitro resistance selection against second-/last-line antibiotics in methicillin-resistant Staphylococcus aureus
SORBS1的替代剪接影响肌强直性营养不良1型中的神经肌肉接头形成和稳定性 Hermitte, C. PDF N/A Alternative splicing of SORBS1 affects neuromuscular junction formation and stability in myotonic dystrophy type 1
分裂酵母中不同细胞位点的内吞斑动态受到差异性调控 Campbell, B. F. PDF N/A Endocytic Patch Dynamics are Differentially Regulated at Distinct Cell Sites in Fission Yeast
小鼠原肠胚形成的空间时间调控逻辑 Yang, X. PDF N/A Spatiotemporal Regulatory Logics of Mouse Gastrulation
地理分布对中美洲脂鲤鱼类单殖吸虫寄生虫(扁形动物门)多样化的预测作用强于宿主亲缘关系。 Alda, F. PDF N/A Geography is a stronger predictor of diversification of monogenean parasites (Platyhelminthes) than host relatedness in characid fishes of Middle America
一种针对地中海实蝇的自限性无菌昆虫技术替代方案 Davydova, S. PDF N/A A self-limiting Sterile Insect Technique alternative for Ceratitis capitata
色氨酸代谢物图谱揭示了器官、年龄和性别特异性的变异 Perez-Castro, L. PDF N/A Tryptophan metabolite atlas uncovers organ, age, and sex-specific variations
人类疾病中的蛋白质稳态特征 Lim, C. M. PDF N/A Proteostasis Signatures in Human Diseases
CORTADO: 用于细胞类型特异性标记基因发现的爬山优化 Lodi, M. PDF N/A CORTADO: Hill Climbing Optimization for Cell-Type SpecificMarker Gene Discovery
FAIRSCAPE:一个不断发展的生物医学研究AI准备框架 Al Manir, S. PDF N/A FAIRSCAPE: An Evolving AI-readiness Framework for Biomedical Research
通过精确预测三维DNA力学,探索不同真核生物基因组中的机械选择 Park, J. PDF N/A Probing mechanical selection in diverse eukaryotic genomes through accurate prediction of 3D DNA mechanics
功能性不对称下的步态适应:探究步宽、步长和质心在侧向稳定性中的作用 Bacek, T. PDF N/A Gait Adaptations Under Functional Asymmetry: Exploring the Role of Step Width, Step Length, and CoM in Lateral Stability
测试纤维蛋白原样1在代谢功能障碍相关脂肪性肝病和肝细胞癌发病机制中的贡献 Personnaz, J. PDF N/A Testing the contribution of fibrinogen like 1 to the pathogenesis of metabolic dysfunction associated steatotic liver disease and hepatocellular carcinoma
职业苯暴露引起的小鼠代谢失调的综合多组学分析 Scofield, S. PDF N/A Integrative multiomics analysis of metabolic dysregulation induced by occupational benzene exposure in mice
基于温度的MHC I类多聚体肽交换用于人类HLA-A、B和C Pothast, C. R. PDF N/A Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C
PfATP2是恶性疟原虫表面的一种关键翻转酶,影响寄生虫对疟疾药物的敏感性。 Qiu, D. PDF N/A PfATP2 is an essential flippase on the Plasmodium falciparum surface that influences parasite sensitivity to antiplasmodial compounds
在年轻物种群中的渐渗与分化 Satokangas, I. PDF N/A Introgression and divergence in a young species group
通过单粒子追踪技术揭示活细胞表面上的DNA折纸相互作用动力学 Van Zundert, I. PDF N/A Unveiling DNA Origami Interaction Dynamics on Living Cell Surfaces by Single Particle Tracking
单细胞扰动响应预测模型的系统性比较 Li, L. PDF N/A A Systematic Comparison of Single-Cell Perturbation Response Prediction Models
在情节记忆期间的网络隔离显示出从7岁到82岁与记忆表现之间的年龄不变关系 Grydeland, H. PDF N/A Network Segregation During Episodic Memory Shows Age-Invariant Relations with Memory Performance From 7 to 82 Years
一个简单的体外膀胱感染模型允许研究尿路感染中的宿主-病原体相互作用。 Koehn, R.-M. PDF N/A A simple ex vivo bladder infection model permits study of host-pathogen interactions in UTI
台湾灵芝多糖通过下调髓源性抑制细胞和肿瘤相关巨噬细胞的分化来增强抗肿瘤免疫反应。 Yang, J.-Y. PDF N/A Ganoderma formosanum polysaccharides enhance antitumor immune responses by downregulating the differentiation of myeloid-derived suppressor cells and tumor-associated macrophages
一种噬菌体编码的反防御机制抑制了NAD降解的抗噬菌体防御系统。 Loyo, C. PDF N/A A phage-encoded counter-defense inhibits an NAD-degrading anti-phage defense system
非洲和亚洲对青蒿素具有不同敏感性的恶性疟原虫分离株的配子体产生和传播适应性 Proellochs, N. I. PDF N/A Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins
植物先锋因子LFY在脊椎动物中利用跨界的染色质重塑机制。 Ribeiro, F. PDF N/A The plant pioneer factor LFY uses trans-kingdom chromatin remodeling mechanisms in vertebrates
纤维化样胶原基质作为创新的3D体外模型,用于研究病理性细胞外基质对肌肉营养不良中肌肉再生的影响。 Camman, M. PDF N/A Fibrotic-like collagen matrices as innovative 3D in vitro models for investigating the impact of pathological ECM on muscle regeneration in muscular dystrophies
MAPK15 对代谢功能障碍相关脂肪性肝病的发生具有保护作用 Inzalaco, G. PDF N/A MAPK15 Protects Against The Development Of Metabolic Dysfunction-Associated Steatotic Liver Disease
Methyl-CODEC技术实现了同时进行甲基化和双链测序。 Liu, R. PDF N/A Methyl-CODEC enables simultaneous methylation and duplex sequencing
MacqD - 一种基于深度学习的模型,用于自动检测社会饲养实验室猕猴 Moat, G. J. PDF N/A MacqD - A Deep Learning-based Model for Automatic Detection of Socially-housed Laboratory Macaques
自适应光学滚动狭缝眼底镜:在多模态视网膜成像仪中结合细胞级分辨率、高速和大视场 Krafft, L. PDF N/A Adaptive Optics Rolling Slit Ophthalmoscope: Combining cellular-resolution, high-speed and large field-of-view in a multimodal retinal imager
用于无偏建模细菌菌落生长的流体衍生晶格 Verhoef, B. PDF N/A Fluid-Derived Lattices for Unbiased Modeling of Bacterial Colony Growth
APR-246 和 COTI-2 通过 ROS 诱导的 DNA 损伤和铁死亡增加 p53 突变型 HPV 阴性头颈部鳞状细胞癌的化学放疗敏感性 de Bakker, T. PDF N/A APR-246 & COTI-2 increase chemoradiotherapy sensitivity via ROS-induced DNA damage and ferroptosis in p53 mutant HPV negative head and neck squamous cell carcinoma
节能代谢开关是极端嗜盐红微藻在极高镍水平下生存的基础。 Santaeufemia, S. PDF N/A The energy-saving metabolic switch underlies survival of extremophilic red microalgae in extremely high nickel levels
基因网络结构、突变和选择共同推动了发育模式的可进化性和可预测性。 Booth, H. PDF N/A Gene network architecture, mutation and selection collectively drive developmental pattern evolvability and predictability
研究乙二醛酶1在可卡因和羟考酮使用障碍中的治疗靶点作用 Alcantara, E. PDF N/A Investigating the Role of Glyoxalase 1 as a Therapeutic Target for Cocaine and Oxycodone Use Disorder
Grin2a消融显著重塑了内侧前额叶皮层中PV+和SST+中间神经元的电路,从而放大了伽马振荡。 Hosseini, H. PDF N/A Grin2a Ablation Distinctly Reshapes PV+ and SST+ Interneuron circuits in the Medial Prefrontal Cortex to Amplify Gamma Oscillations
皮层中新奇性的关键性扩展 Ribeiro, T. L. PDF N/A Critical Scaling of Novelty in the Cortex
YAP调节骨折修复中的骨膜扩张 Nijsure, M. P. PDF N/A YAP regulates periosteal expansion in fracture repair
从计算角度重建癌症进展风险演变 Cao, K. PDF N/A Computationally reconstructing the evolution of cancer progression risk
在哥伦比亚弗洛伦西亚,卡克塔地区,基于干饲料、活饲料和湿饲料的三种饮食对盘丽鱼(Symphysodon p.)在受控条件下的最佳生长进行了评估。 Navarro-Morales, A. PDF N/A Evaluation of Three Diets Based on Dry, Live, and Wet Feeds for Optimal Growth of Discus Fish (Symphysodon p.) Under Controlled Conditions in Florencia, Caqueta, Colombia
在抗原暴露后早期出现的异质性活化B细胞群的特征,该群细胞在长寿命记忆B细胞形成之前出现。 Fernandez Blanco, L. PDF N/A Characterization of a heterogenous activated B cell compartment arising early after antigen exposure preceding long-lived memory B cell formation
Tecovirimat对猴痘病毒分支1a、1b、2a和2b的抗病毒活性 Postal, J. PDF N/A Antiviral activity of Tecovirimat against Mpox virus clades 1a, 1b, 2a and 2b
LEF1-AS1在持续性新冠症状患者外周血中的失调 Made, A. PDF N/A LEF1-AS1 deregulation in the peripheral blood of patients with persistent post-COVID symptoms
基因表达受到相互作用的核苷酸供应和mRNA组成需求的全球性调控:这一机制被多种疾病状态和药物治疗所破坏。 Pickard, B. S. PDF N/A Gene expression is globally regulated by interacting nucleobase supply and mRNA composition demand: a mechanism disrupted by multiple disease states and drug treatments
一种基于甲基化的年龄预测方法的综合评估 Wang, H. PDF N/A A Comprehensive Assessment of Methylation-Based Age Prediction Methods
通过多轮肽结合实验结合自由能回归,为SH2结构域构建精确的序列到亲和力模型 Gagoski, D. PDF N/A Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression
运动前β活动的出现与稳定的感知运动预测相结合,以促进运动调整 Bracco, M. PDF N/A Emergence of Pre-movement Beta Activity with Stable Sensorimotor Predictions to Facilitate Motor Adjustments
运动过程中大脑灌注及星形胶质细胞和神经元的代谢反应 Tiaglik, A. PDF N/A Cerebral perfusion and metabolic response of astrocytes and neurons during locomotion
噪声中语音的听觉脑干反应反映了选择性注意、理解能力以及主观听力努力程度。 Mankel, K. PDF N/A Auditory brainstem responses to speech-in-noise reflect selective attention, comprehension, and subjective listening effort
WASp介导的肌动蛋白聚合作用限制了巨噬细胞中核膜破裂和炎症的发生。 Amadio, R. PDF N/A Actin polymerization by WASp limits nuclear envelope rupture and inflammation in macrophages
从尼日利亚伊巴丹市家庭水源分离出的埃希氏大肠杆菌中抗菌药物耐药性的遗传基础 Akintayo, I. J. PDF N/A Genetic basis for antimicrobial resistance in Escherichia coli isolated from household water in municipal Ibadan, Nigeria
细菌周质捕食的定量蛋白质组揭示了捕食对象损伤蛋白酶 Lai, T. F. PDF N/A Quantitative proteome of bacterial periplasmic predation reveals a prey damaging protease
细胞质过氧化物酶Tsa1影响葡萄酒酵母的醋酸代谢和pH稳态 Garrigos, V. PDF N/A Cytosolic peroxiredoxin Tsa1 influences acetic acid metabolism and pH homeostasis in wine yeasts
通过海洋硅藻Phaeodactylum tricornutum中的RITMO1时钟蛋白对关键生理过程的昼夜节律调控 Manzotti, A. PDF N/A Circadian regulation of key physiological processes by the RITMO1 clock protein in the marine diatom Phaeodactylum tricornutum
血管紧张素II在近球小体细胞簇内引发强烈的钙离子振荡,这种协调的振荡作用抑制了肾素的分泌。 Yamaguchi, H. PDF N/A Angiotensin II elicits robust calcium oscillations coordinated within juxtaglomerular cell clusters to suppress renin secretion.
LBR和LAP2介导异染色质与核膜的结合,以维持基因组的稳态。 Lewis, R. PDF N/A LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis
TRF1和TRF2在端粒处形成不同的shelterin亚复合物。 Janovic, T. PDF N/A TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres
eDNA通过整合生物能量学和颗粒物质量平衡,提供了对生物丰度的准确和精确估计。 Beaulieu, J. PDF N/A eDNA provides accurate and precise estimates of abundance by integrating bioenergetics and particle mass-balance
在酶进化过程中,残基间结构分歧的变化 Echave, J. PDF N/A On the variation of structural divergence among residues in enzyme evolution
全转录组分析显示,感染牛白血病病毒(BLV)的牛中,高前病毒载量牛的免疫反应基因呈现下调趋势。 Petersen, M. I. PDF N/A Whole-transcriptome analysis of BLV-infected cows reveals downregulation of immune response genes in high proviral loads cows.
性特异性鱼类重组景观将重组与染色体组型进化联系起来 Kivioja, T. PDF N/A Sex-specific fish recombination landscapes link recombination and karyotype evolution
对真菌高还原性聚酮合酶缩合区进行生化剖析揭示了酰基选择的基础。 Foran, M. E. PDF N/A Biochemical dissection of a fungal highly reducing polyketide synthase condensing region reveals basis for acyl group selection.
自行动手从头开始抗体测序工作流程,实现可变区域完全准确性 He, M.-T. PDF N/A Do-it-yourself de novo antibody sequencing workflow that achieves complete accuracy of the variable regions
SHP2通过双酪氨酸磷酸化的Gab1激活的机制 Machner, L. PDF N/A Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1
用于细胞成像中精准表型分析的混杂因素感知基础模型 Papanastasiou, G. PDF N/A Confounder-aware foundation modeling for accurate phenotype profiling in cell imaging
全基因组鉴定、表征及黄瓜(Cucumis sativus L)CsC3H基因家族在多种非生物胁迫下的表达分析 Uddin, S. PDF N/A Genome-wide identification, characterization and expression analysis of CsC3H gene family in cucumber (Cucumis sativus L) under various abiotic stresses
YDS-Ternoplex:超越AlphaFold 3型模型,用于分子胶介导的三元复合物预测 Che, X. PDF N/A YDS-Ternoplex: Surpassing AlphaFold 3-Type Models for Molecular Glue-Mediated Ternary Complex Prediction
在实验室中展示用于关联低温生物成像的软X射线断层扫描技术,结合使用X射线和光学显微镜。 O'Connor, S. PDF N/A Demonstrating Soft X-Ray Tomography in the lab for correlative cryogenic biological imaging using X-rays and light microscopy
Ephrin-A5和EphA7的刺激在体外对人横纹肌肉瘤具有抗增殖作用。 Cecchini, A. PDF N/A Ephrin-A5 and EphA7 stimulation is anti-proliferative for human rhabdomyosarcoma in vitro
MITF、TFEB和TFE3的功能特化驱动了黑色素瘤中截然不同的适应性基因表达程序。 Dias, D. PDF N/A Functional specialization of MITF, TFEB and TFE3 drives radically distinct adaptive gene expression programs in melanoma.
探索腺苷类似物用于软骨肉瘤治疗:体外和体内研究 Lente, M. PDF N/A Exploring Adenosine Analogues for Chondrosarcoma Therapy: In Vitro and In Vivo Insights
探索高LET氧离子FLASH辐射在体外和体内靶向胰腺癌的应用 Karle, C. PDF N/A Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo
昼夜节律PERIOD蛋白塑造了哺乳动物的替代剪接景观。 Chikhaoui, L. PDF N/A Circadian PERIOD proteins sculpt themammalian alternative splicing landscape
通过泛素-蛋白酶体系统直接调控孢子体向配子体的转变 Sivakumar, P. PDF N/A Sporophyte Directed Gametogenesis via the Ubiquitin Proteasome System
模拟阿塔卡马地貌中土壤微生物群的新陈代谢潜能 Andreani-Gerard, C. M. PDF N/A Modeling the emergent metabolic potential of soil microbiomes in Atacama landscapes
利用突触修剪的细胞模型鉴定能够穿透血脑屏障的小分子人小胶质细胞调节剂 McCrea, L. M. PDF N/A Identifying brain-penetrant small molecule modulators of human microglia using a cellular model of synaptic pruning
使用深度生成模型进行大脑和行为的同步表征与预测建模:一个从监督到非监督的渐进式建模框架。 McVeigh, K. PDF N/A Using deep generative models for simultaneous representational and predictive modeling of brain and behavior: A graded supervised-to-unsupervised modeling framework.
收集、检测和处理纵向光暴露数据中的非穿戴间隔 Guidolin, C. PDF N/A Collecting, detecting and handling non-wear intervals in longitudinal light exposure data
用于控制外周视觉的中央凹作用 Zhang, T. PDF N/A Foveal action for the control of extrafoveal vision
通过高吞吐量的光学生理学剖析谷氨酸能突触的功能异质性 Barlow, S. T. PDF N/A Dissecting the functional heterogeneity of glutamatergic synapses with high-throughput optical physiology
放射状胶质祖细胞中细胞周期调节因子cyclin D1的细胞质表达,调控大脑皮层发育 PEDRAZA, N. PDF N/A Cytoplasmic expression of the cell cycle regulator cyclin D1 in radial glial progenitor cells modulates brain cortex development
在呼吸道病毒感染后诱导的I型干扰素会损害肺部转移的起始。 Farias, A. PDF N/A Type I interferons induced upon respiratory viral infection impair lung metastatic initiation
哺乳动物的ZAP和KHNYN独立地限制富含CpG的禽类病毒。 Becker, J. T. PDF N/A Mammalian ZAP and KHNYN independently restrict CpG-enriched avian viruses
含有内含子的HIV-1 RNA的表达在髓系细胞中诱导NLRP1炎症小体激活 Jalloh, S. PDF N/A Expression of Intron-containing HIV-1 RNA Induces NLRP1 Inflammasome Activation in Myeloid Cells
一种特殊的细菌II类内含子是一种高效的逆转录转座子。 Gomes, L. PDF N/A A specialized bacterial group II intron is a highly efficient retrotransposon
BAX内有一个带门控的疏水通道,能够结合长链烯醛,从而增强其促凋亡功能。 Gelles, J. D. PDF N/A A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function
视紫红质组装核心的靶向递送对于小鼠视杆光感受器外节延伸是必需的。 Martinez-Marquez, J. Y. PDF N/A Targeted delivery of rhodopsin's assembled core is required for outer segment extension in mouse rod photoreceptors
POLO激酶通过抑制蛋白磷酸酶1来促进纺锤体组装检验点,并防止非整倍体。 Moura, M. PDF N/A POLO kinase inhibits Protein Phosphatase 1 to promote the Spindle Assembly Checkpoint and prevent aneuploidy
β整合素中的NPxY基序调控秀丽隐杆线虫的血清素反应和机械感受。 Bumm, J. H. PDF N/A The NPxY motifs in the β integrin regulate serotonin response and mechanosensation in C. elegans
肿瘤源性胶质生成在果蝇中枢神经系统中维持了依赖去分化的肿瘤生长。 Alvarez-Ochoa, E. PDF N/A Tumour-derived gliogenesis sustains dedifferentiation-dependent tumour growth in the Drosophila CNS
在无腔动物中,肌肉损伤诱导的神经营养素-ErbB信号传导能够动员干细胞,促进全身再生。 Stevens, B. PDF N/A Injury-induced Neuregulin-ErbB signaling from muscle mobilizes stem cells for whole-body regeneration in Acoels
评估字符进化模型对从化石数据中进行系统发育和宏观进化推断的影响 Wright, D. F. PDF N/A Assessing the impact of character evolution models on phylogenetic and macroevolutionary inferences from fossil data
从体细胞拷贝数谱中进行一致性整合与特征提取 Streck, A. PDF N/A CNSistent integration and feature extraction from somatic copy number profiles
交配频率在偶发性多配雄性螨虫的个性表达中起着中介作用。 SCHAUSBERGER, P. PDF N/A MATING FREQUENCY MEDIATES PERSONALITY EXPRESSION IN FACULTATIVELY POLYANDROUS MITES
点击连接:一种基于点击化学的细胞兼容性蛋白质交联方法 Amaral, B. C. PDF N/A Click-linking: a cell-compatible protein crosslinking method based on click chemistry
Setdb1和Atf7IP形成了一个异源三聚体复合物,该复合物阻断了Setdb1的核输出。 Kariapper, L. S. PDF N/A Setdb1 and Atf7IP form a hetero-trimeric complex that blocks Setdb1 nuclear export
伯克霍尔德菌假单胞菌OXA-57的结构与动力学:一种具有碳青霉烯水解活性的独特低效D类β-内酰胺酶 Bragginton, E. PDF N/A Structure and dynamics of Burkholderia pseudomallei OXA-57, a distinctive low-efficiency class D β-lactamase with carbapenem-hydrolyzing activity
采用前沿检测技术的宽场光学氧化还原成像用于评估源自患者的癌症类器官 Gillette, A. A. PDF N/A Wide-field optical redox imaging with leading-edge detection for assessment of patient-derived cancer organoids
N-氨基肽-石墨烯量子点负载的小型细胞外囊泡用于Tau病变靶向治疗 Zhu, R. PDF N/A N-Amino Peptide-Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies
PRISM:一个用于多重组织微阵列交互式和集成分析的Python包 Tubelleza, R. PDF N/A PRISM: A Python Package for Interactive and Integrated Analysis of Multiplexed Tissue Microarrays
药效团设计与集合对接方法在大规模数据库筛选中用于鉴定粪肠球菌APH(3')-IIIa潜在抑制剂 Velez, L. A. PDF N/A Pharmacophore design and ensemble-docking as approach to screening a large-scale database for identification of potential inhibitors of APH(3')-IIIa of Enterococcus faecalis
基于代理的建模揭示了细胞粘附和基质重塑对癌症集体细胞迁移表型的影响 Benson, T. O. PDF N/A Agent-based modeling reveals impacts of cell adhesion and matrix remodeling on cancer collective cell migration phenotypes
核小体间距能够微调更高阶的染色质组装 Chen, L. PDF N/A Nucleosome Spacing Can Fine-Tune Higher Order Chromatin Assembly
估计由微血管驱动的皮质脑组织中的流体流速 Koch, T. PDF N/A Estimation of fluid flow velocities in cortical brain tissue driven by the microvasculature
底栖硅藻运动模式的多样性 Bondoc-Naumovitz, K. G. PDF N/A Diversity of motility patterns in benthic diatoms
CoREST复合物调控MYC的稳定性,并促进黑色素瘤中mRNA的转录后剪接。 Ryu, B. PDF N/A The CoREST-complex regulates MYC stability and promotes post-transcriptional mRNA splicing in melanoma
肠道和免疫系统中雌激素介导炎症的数学建模 Lighty, A. M. PDF N/A Mathematical Modeling of Estrogen-Mediated Inflammation in the Gut and Immune System
生命最初两年脑电微状态网络的时空动态:一项多队列纵向研究 Ghosh, P. PDF N/A Spatiotemporal dynamics of EEG microstate networks over the first two years of life: A multi-cohort longitudinal study
真菌多于腿:首个食真菌千足虫(倍足纲)的真菌微生物组 Macias, A. M. PDF N/A More fungi than legs: the first fungal microbiome for a fungus-eating millipede (Colobognatha)
KHNYN延伸的diKH结构域的结构和功能表征,用于介导ZAP抗病毒活性 Youle, R. L. PDF N/A Structural and functional characterization of the KHNYN extended-diKH domain for mediating ZAP antiviral activity
细胞质中的半胱氨酰-tRNA合成酶能够调控ATF4的翻译,而不依赖于eIF2α的磷酸化状态。 Xu, A. E. PDF N/A The cytosolic cysteinyl-tRNA synthetase is capable of regulating ATF4 translation independent of eIF2α phosphorylation state
代谢调控有助于痛觉感受器抵抗兴奋性毒性 Yuan, L. PDF N/A Metabolic tuning facilitates nociceptor resilience to excitotoxicity
生物分子凝聚物控制并由RNA-RNA相互作用所定义,这些相互作用是在病毒复制过程中产生的。 Aierken, D. PDF N/A Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication
单细胞细胞器提取与细胞索引 Lam, T. PDF N/A Single-cell Organelle Extraction with Cellular Indexing
PAX2通过一种独特的表观遗传重编程机制被转录沉默,从而启动子宫内膜癌的发生。 Sahoo, S. S. PDF N/A PAX2 is Transcriptionally Silenced by a Distinct Mechanism of Epigenetic Reprogramming to Initiate Endometrial Carcinogenesis