BioRxiv 2024-12-25 Papers

标题	作者	PDF链接	代码仓库	Title
较高的基础肿瘤免疫活性结合全身免疫反应可改善肝癌的预后。	Alipour Talash, G.	PDF	N/A	Higher basal tumor immune activity coupled with a systemic immune response improves liver cancer outcomes
神经血管耦合反过来调节情绪	Ruan, J.	PDF	N/A	Neurovascular coupling conversely modulates emotion
Pu.1/Spi1的剂量控制着斑马鱼和哺乳动物中小胶质细胞的更新与维持。	Wu, Y.	PDF	N/A	Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals
通过DNA初免-蛋白加强策略增强针对构象非RBD区域的抗体反应，可引发对SARS-CoV-2变种的广泛交叉中和作用。	Ma, Y.-F.	PDF	N/A	Enhanced Antibody Response to the Conformational Non-RBD Region via DNA Prime-Protein Boost Elicits Broad Cross-Neutralization Against SARS-CoV-2 Variants
广义哈代-温伯格（GH）模型解决了分子进化中的诸多悖论	Ruan, Y.	PDF	N/A	The Generalized Haldane (GH) model of genetic drift resolving the many paradoxes of molecular evolution
一种研究小麦赤霉病复合体形成过程中多物种相互作用的实验方法。	Corrales Gutierrez, M. A.	PDF	N/A	An experimental approach to study multi-species interactions implicated in Fusarium-Head Blight complex assembly in wheat.
胎盘疟疾与人类胎盘组织中的TLR-内皮素-3-氧化损伤反应相关。	Chenge, S.	PDF	N/A	Placental malaria is associated with a TLR-Endothelin-3-oxidative damage response in human placenta tissues
外泌体miRNA-124通过调节CD45的替代剪接参与宫颈癌的免疫调控。	Liang, M.	PDF	N/A	Exosomal miRNA-124 is involved in the immune regulation of cervical cancer by regulating CD45 alternative splicing
外泌体miRNA-124通过调控CD45的可变剪接参与宫颈癌的免疫调节。	Liang, M.	PDF	N/A	Exosomal miRNA-124 is involved in the immune regulation of cervical cancer by regulating CD45 alternative splicing
谷胱甘肽对暴露于850-1900 MHz手机辐射的小鼠肝酶和血清电解质的影响	Binhambali, A.	PDF	N/A	Glutathione Effects on Liver Enzymes and Serum Electrolyte in Mice Exposed to 850 1900 MHz Mobile Phone Radiation
两个远缘果蝇物种在变态过程中基因表达的时间动态	Ozerova, A. M.	PDF	N/A	Temporal dynamics of gene expression during metamorphosis in two distant Drosophila species
揭示小鼠血清淀粉样蛋白A3在动脉粥样硬化进展过程中对主动脉免疫细胞亚群的免疫学作用	Chou, T.-Y.	PDF	N/A	Unraveling the immunological roles of murine serum amyloid A3 in aortic immune cell subsets during atherosclerosis progression
BA.2.86的早期演化揭示了高度分化的SARS-CoV-2谱系的起源	Escalera-Zamudio, M.	PDF	N/A	Early evolution of BA.2.86 sheds light on the origins of highly divergent SARS-CoV-2 lineages
在Scn8a功能增益小鼠中，持续的Na+电流将癫痫发作与扩散性去极化耦合在一起。	Aiba, I.	PDF	N/A	Persistent Na+ current couples seizure with spreading depolarization in Scn8a gain of function mice
在鼠类临床前肺部感染模型中，O特异性抗原的缺失塑造了铜绿假单胞菌种群的微生物地理分布。	Fraser, H.	PDF	N/A	Loss of O-specific antigen shapes Pseudomonas aeruginosa population microbiogeography in murine preclinical pulmonary infection model
基因组语言模型的局限性与增强：动态选择方法	Qiu, S.	PDF	N/A	Limitations and Enhancements in Genomic Language Models: Dynamic Selection Approach
能量变化预测冈比亚按蚊的死亡率	Zeferino, T. G.	PDF	N/A	Energetic shifts predict the mortality of Anopheles gambiae
跨睡眠阶段的时程解析神经振荡：与睡眠质量和衰老的关联	Passaro, A. D.	PDF	N/A	Time-Resolved Neural Oscillations Across Sleep Stages: Associations with Sleep Quality and Aging
细菌表面的血红素结合DNA结构促进细胞外电子传递	Ajunwa, O. M.	PDF	N/A	Hemin-binding DNA structures on the surface of bacteria promote extracellular electron transfer
通过泛素蛋白酶体系统实现孢子体导向的配子发生	Sivakumar, P.	PDF	N/A	Sporophyte Directed Gametogenesis via the Ubiquitin Proteasome System
生物分子凝聚体控制并定义了病毒复制过程中产生的RNA-RNA相互作用。	Aierken, D.	PDF	N/A	Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication
长读长测序揭示了双壳类动物线粒体基因组中存在广泛的尺寸变异，并暗示了其扩展的进化模式。	Zhang, N.	PDF	N/A	Long-read sequencing reveals extensive size variation and suggests evolutionary patterns of expansion in bivalve mitogenomes
致病性错义突变对Menin蛋白功能的动态介导效应的分子机制	Zhang, Q.	PDF	N/A	Molecular mechanisms of dynamics-mediated effects of pathogenic missense mutations on Menin protein function
新生RNA分析揭示了细菌通过高效重复起始对基因转录的调控。	Sun, Z.	PDF	N/A	Nascent RNA profiling reveals regulation of gene transcription through productive reiterative initiation in bacteria
以下是这段英文的中文翻译：

"在恒河猴成年期，基于血液的神经退行性变和炎症生物标志物的表达模式"

翻译说明： 1. "Expression patterns" 翻译为 "表达模式" 2. "blood-based biomarkers" 翻译为 "基于血液的生物标志物" 3. "neurodegeneration" 翻译为 "神经退行性变" 4. "inflammation" 翻译为 "炎症" 5. "across adulthood" 翻译为 "在成年期" 6. "rhesus macaques" 翻译为 "恒河猴"

这个翻译准确地传达了原文的意思，描述了在恒河猴成年期，通过血液检测来研究神经退行性变和炎症相关生物标志物的表达变化的研究内容。 | Metzler, L. A. P. | PDF | N/A | Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques | | 线虫衰老过程中线粒体成像策略的交叉比较。 | Kim, J. | PDF | N/A | Cross comparison of imaging strategies of mitochondria in C. elegans during aging. | | 在人类世时期，全球授粉者生物多样性的下降。 | Kallivalappil, R. | PDF | N/A | The decline of global pollinator biodiversity in the Anthropocene | | 脂肪酸硫酯酶A与129个片段结合的晶体结构为多样化的发展机会提供了基础。 | Kot, E. | PDF | N/A | Crystal structure of Fatty Acid Thioesterase A bound by 129 fragments provides diverse development opportunities | | 通过整合生物信息学方法对小鼠肿瘤细胞的差异表达基因进行鉴定与分析 | Jing, X. | PDF | N/A | Identification and analysis of DEGs of mouse tumor cells by integrated bioinformatics methods | | Isopeptor：一种用于检测蛋白质结构中分子内异肽键的工具 | Costa, F. | PDF | N/A | Isopeptor: a tool for detecting intramolecular isopeptide bonds in protein structures | | 炎症在人源化小鼠模型中转甲状腺素蛋白心脏淀粉样变性的作用 | Wu, X. | PDF | N/A | The role of inflammation in a humanized mouse model of transthyretin cardiac amyloidosis | | 支持近端结肠运动复合体节律性启动新假说的实验数据 | Morales-Soto, W. | PDF | N/A | Experimental data supporting a novel hypothesis for the rhythmic initiation of proximal colon motor complexes | | 利用体细胞超突变在人体细胞中进行无病毒持续定向进化 | Bram, S. | PDF | N/A | Virus-free continuous directed evolution in human cells using somatic hypermutation | | WWOX基因缺陷会损害人类类器官中的神经发生和神经元功能。 | Steinberg, D. J. | PDF | N/A | WWOX deficiency impairs neurogenesis and neuronal function in human organoids | | 解剖到束路映射：无需扩散流线传播推断白质路径 | Tan, Y.-F. | PDF | N/A | Anatomy-to-Tract Mapping: Inferring White Matter Pathways Without Diffusion Streamline Propagation | | Afadin缺失的视网膜表现出严重的神经元层化缺陷，但仍保留视觉功能。 | Ueno, A. | PDF | N/A | Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions | | 不同的皮层群体驱动多感官调节分离的听觉源 | Cai, H. | PDF | N/A | Distinct cortical populations drive multisensory modulation of segregated auditory sources | | Afadin将不同类型的视网膜神经元精确分类至相应的细胞层中。 | Lum, M. R. | PDF | N/A | Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers | | 全面分析小RNA及其在精神分裂症和双相情感障碍中的变化及其与mRNA的关联 | Nersisyan, S. | PDF | N/A | Comprehensive profiling of small RNAs and their changes and linkages to mRNAs in schizophrenia and bipolar disorder | | 在持续性病毒感染期间，CD4 T细胞非依赖性的IgG反应有利于中和逃逸变异株的出现。 | Ayers, K. N. | PDF | N/A | The CD4 T cell-independent IgG response during persistent virus infection favors emergence of neutralization-escape variants | | 在可检测到的HIV-1反弹病毒血症之前，炎症性单核细胞数量增加。 | Farrell-Sherman, A. | PDF | N/A | Inflammatory Monocytes Increase Prior to Detectable HIV-1 Rebound Viremia | | 玉米及其野生近缘种在多倍体化后表现出明显的基因组缩减模式。 | Snodgrass, S. J. | PDF | N/A | Maize and wild relatives show distinct patterns of genome downsizing following polyploidy | | 了解绵羊跟骨附着点的结构和力学特性：一种适用于组织工程应用的相关动物模型 | Sensini, A. | PDF | N/A | Understanding the structure and mechanics of the sheep calcaneal enthesis: a relevant animal model for tissue engineering applications | | 通过对感染无毒和有毒结核分枝杆菌的巨噬细胞进行综合分析，揭示了不同的免疫机制及处理后的外泌体的抗结核作用。 | Yang, L. | PDF | N/A | Comprehensive analysis of macrophages infected with avirulent and virulent Mycobacterium tuberculosis uncovers distinct immune mechanisms and anti-TB effect of treated exosomes | | 单细胞分析揭示小鼠表皮肿瘤进展过程中的全局免疫反应 | Fan, X. | PDF | N/A | Single-Cell Profiling Reveals Global Immune Responses during the Progression of Murine Epidermal Neoplasms | | 基质导向药物联合化疗对胰腺癌的疗效——一项临床前研究 | Gupta, M. | PDF | N/A | Effect of Stroma-directed Drugs in Combination with Chemotherapy Against Pancreatic Cancer- a Preclinical Study | | 在对抗行为偏见的趋近-回避结果转换中，中型棘状神经元亚型的瞬时多巴胺反应——行动选择探索的框架

这段翻译成中文的意思是：在研究如何克服行为偏见，实现趋近与回避结果之间的转换时，中型棘状神经元的不同亚型会表现出短暂的多巴胺反应。这一现象为探索行动选择提供了一个理论框架。 | Anisetty, N. | PDF | N/A | Transient dopamine response on medium spiny neuron subtypes in switching approach-avoidance outcomes against action bias - A framework for exploration in action selection | | 在尼日利亚伊巴丹，缓慢生长的伤寒沙门氏菌被误鉴定为鸡沙门氏菌。 | Sunmonu, G. T. | PDF | N/A | Slow-growing Salmonella enterica Typhi mis-identified as Salmonella Gallinarum in Ibadan, Nigeria | | 受人类凝集素启发的聚糖分析探针用于研究宿主-微生物相互作用 | Ghosh, S. | PDF | N/A | Glycan analysis probes inspired by human lectins for investigating host-microbe crosstalk | | 结构导向的α-酮异己酸双加氧酶工程提高了集胞藻PCC 6803中异丁烯的产量 | Schumann, C. | PDF | N/A | Structure-guided engineering of α-ketoisocaproate dioxygenase increases isobutene production in Synechocystis sp. PCC 6803 | | CorrAdjust通过高效消除隐藏的混杂因素，揭示了具有生物学意义的转录组相关性。 | Nersisyan, S. | PDF | N/A | CorrAdjust unveils biologically relevant transcriptomic correlations by efficiently eliminating hidden confounders | | 基于几何的BERT：一种经过实验验证的深度学习模型，用于药物发现中的分子性质预测 | Zhang, X. | PDF | N/A | Geometry-based BERT: an experimentally validated deep learning model for molecular property prediction in drug discovery | | 海马神经元中STIM1和STIM2在ER-PM接触位点的活动依赖性定位及异质性动力学。 | Chhikara, A. | PDF | N/A | Activity-Dependent Localization and Heterogeneous Dynamics of STIM1 and STIM2 at ER-PM contacts in Hippocampal Neurons. | | Prohibitin 2 是体内 T 细胞增殖、分化和效应功能的关键调节因子。 | Vogt, J. F. | PDF | N/A | Prohibitin 2 is a Key Regulator of T Cell Proliferation, Differentiation, and Effector Functions in vivo | | 了解遗传结构有助于克服种子质量与抗虫性之间的权衡关系。 | White, J. R. | PDF | N/A | Understanding genetic architecture overcomes tradeoffs between seed quality and insect resistance | | 系统性评估高通量亚细胞空间转录组学平台 | Ren, P. | PDF | N/A | Systematic Benchmarking of High-Throughput Subcellular Spatial Transcriptomics Platforms | | 使用样本定制的最小化文库进行精确且可扩展的宏基因组分析 | Nystrom-Persson, J. | PDF | N/A | Precise and scalable metagenomic profiling with sample-tailored minimizer libraries | | 基于长短期记忆网络的土地利用类型演变预测方法——以甘肃省为例 | Zhang, S. | PDF | N/A | A Prediction Method of Land Use Type Evolution Based on Long and Short-Term Memory Networks--Taking Gansu Province as an Example | | 基于表型相关标记基因在群体和单细胞中的表达谱推断单细胞的表型 | He, Y. | PDF | N/A | Inferring phenotypes of single cells based on the expression profiles of phenotype-associated marker genes in bulks and single cells | | dGAMLSS：一种精确的分布式算法，用于拟合位置、尺度和形状的广义加性模型，以生成隐私保护的人口参考图表 | Hu, F. | PDF | N/A | dGAMLSS: An exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts | | 横纹肌肉瘤的双读出斑马鱼胚胎异种移植模型，用于评估临床相关的多受体酪氨酸激酶抑制剂 | Wragg, J. W. | PDF | N/A | A dual readout embryonic zebrafish xenograft model of rhabdomyosarcoma to assess clinically relevant multi-receptor tyrosine kinase inhibitors | | 利用无标记多模态非线性光学成像技术对前列腺导管内癌进行纹理分析分类 | Gagnon, J. R. | PDF | N/A | Texture-Analysis Classification of Intraductal Carcinoma of the Prostate Using Label-Free Multimodal Nonlinear Optical Imaging | | 过量表达叶黄素循环基因导致C4单子叶植物绿狗尾草更快适应非光化学淬灭（NPQ） | Stone, W. D. | PDF | N/A | Overexpression of Xanthophyll Cycle Genes Leads to Faster NPQ Acclimation in the C4 Monocot Setaria viridis | | 对性传播寄生虫阴道毛滴虫（Trichomonas vaginalis）的比较基因组学分析揭示了其进化过程中的松弛与趋同现象，以及涉及从鸟类向人类传播的关键基因。 | Sullivan, S. A. | PDF | N/A | Comparative genomics of the sexually transmitted parasite Trichomonas vaginalis reveals relaxed and convergent evolution and genes involved in spillover from birds to humans | | 在芬兰大饥荒期间，繁殖的寿命成本增加了。 | Young, E. A. | PDF | N/A | Lifespan costs of reproduction increase during the Great Finnish Famine | | 选择性离子结合与摄取塑造了生物分子凝聚体的微环境 | Smokers, I. B. A. | PDF | N/A | Selective ion binding and uptake shape the microenvironment of biomolecular condensates | | 剖析髓鞘再生微环境中不断演变的细胞景观 | Melchor, G. S. | PDF | N/A | Dissecting the evolving cellular landscape of a remyelinating microenvironment | | 光遗传学方法在脂质双层上组装肌动蛋白网络揭示了肌动蛋白结合蛋白的网络密度依赖性功能 | Yamamoto, K. | PDF | N/A | Optogenetic actin network assembly on lipid bilayer uncovers the network density-dependent functions of actin-binding proteins | | 比较体外急性和慢性暴露下，全氟辛酸（PFOA）对人血管内皮细胞的顶端和转录组学效应点的敏感性差异 | Opacic, M. | PDF | N/A | Comparative sensitivity of in vitro acute and chronic apical and transcriptomic points of departure for perfluorooctanoic acid in human vascular endothelial cells | | 利用果蝇模型探索AI生成合成肽在提升蜜蜂健康与抵抗力方面的潜力 | Sun, Y. | PDF | N/A | Leveraging Drosophila Models to Explore AI-generated Synthetic Peptide's Potential in Boosting Honeybee Health and Resilience | | ChromBPNet：基于偏差分解、碱基分辨率的深度学习模型揭示染色质可及性中的顺式调控序列语法、转录因子足迹及调控变异

一种用于小鼠尾部情境依赖性运动控制的前庭脊髓通路

解释： - vestibulospinal pathway：前庭脊髓通路，指的是从前庭系统到脊髓的神经传导路径，参与姿势和运动的调节。 - context-dependent：情境依赖性，表示行为或反应会根据具体情境而变化。 - motor control：运动控制，指神经系统对肌肉活动的调节。 - mouse tail：小鼠尾部，指的是实验中小鼠的尾巴。

"南美洲鼠类系统发育基因组学：云雾林和上新世灭绝事件解释了南美洲小鼠和大鼠辐射的时间和扩散"

翻译说明： 1. "Phylogenomics" 译为 "系统发育基因组学"，这是一个结合基因组学和系统发育学的交叉学科。 2. "sigmodontine rodents" 译为 "南美洲鼠类"，指代南美洲特有的一个啮齿动物类群。 3. "Cloud forests" 译为 "云雾林"，指热带和亚热带地区的高海拔森林生态系统。 4. "Pliocene extinction" 译为 "上新世灭绝事件"，指地质年代上新世时期发生的大规模生物灭绝事件。 5. "radiation" 译为 "辐射"，在生物学中指的是一个类群快速分化和多样化的过程。

整句话的意思是：通过系统发育基因组学研究南美洲鼠类的演化历史，发现云雾林的分布和上新世灭绝事件共同解释了这类啮齿动物快速分化的时间进程和地理扩散模式。

"人类内皮细胞和血管平滑肌细胞中基因表达的全局和遗传调控"

翻译解释： - "Global" 在这里指的是“全局的”或“整体的”，表示对基因表达的全面或广泛的研究。 - "Genetic regulation" 指的是“遗传调控”，即基因如何被调控以影响其表达。 - "Gene expression" 是“基因表达”，指的是基因信息被转化为功能蛋白质或 RNA 的过程。 - "Human endothelial and vascular smooth muscle cells" 是“人类内皮细胞和血管平滑肌细胞”，这两种细胞在血管结构和功能中起重要作用。

在这段翻译中，"Nectin-4 PET" 指的是一种利用正电子发射断层扫描（PET）技术来检测Nectin-4表达的方法，Nectin-4是一种在某些癌症中表达的蛋白质。"Enfortumab Vedotin" 是一种针对Nectin-4的抗体药物偶联物，用于治疗尿路上皮癌。"剂量反应" 指的是药物剂量与治疗效果之间的关系。因此，整句话的意思是使用Nectin-4 PET技术来优化Enfortumab Vedotin在尿路上皮癌治疗中的剂量，以达到最佳的治疗效果。 | Mishra, A. | PDF | N/A | Nectin-4 PET For Optimizing Enfortumab Vedotin Dose-Response In Urothelial Carcinoma | | 越南木荷（Schima wallichii (DC.) Korth）中的山柰酚-3-O-鼠李糖苷对人类白血病细胞的细胞毒性活性：体外与计算机模拟的联合研究