BioRxiv 2024-12-27 Papers
| 标题 | 作者 | PDF链接 | 代码仓库 | Title |
|---|---|---|---|---|
| 奥卡姆剃刀如何指导人类决策 | Piasini, E. | N/A | How Occam's razor guides human decision-making | |
| ZapD介导的交联作用促使溶液中短链FtsZ纤维组装成环形结构。 | Merino-Salomon, A. | N/A | Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution | |
| 由胆固醇纳米贴片合成的脂质筏诱导早期T细胞激活 | Jung, Y. | N/A | Synthetic lipid rafts formed by cholesterol nano-patch induce early T cell activation | |
| 在多拷贝基因系统中，由遗传漂变驱动的极快速进化所呈现的悖论 | Wang, X. | N/A | The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems | |
| 通过模仿蝴蝶眼睛来模仿蝴蝶翅膀 | Dang, A. | N/A | Mimetic butterfly wings through mimetic butterfly eyes | |
| 可扩展的超高通量单细胞染色质和RNA测序揭示了基因调控动态，将巨噬细胞极化与自身免疫疾病联系起来。 | Lobato-Moreno, S. | N/A | Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune disease | |
| 通过外部切趾相位对比显微镜对活体哺乳动物细胞内的结构进行无标记成像 | Ohno, H. | N/A | Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy | |
| 放大的耳间声级差异增强了双侧人工耳蜗使用者的空间释放掩蔽效应。 | Richardson, B. N. | N/A | Magnified interaural level differences enhance spatial release from masking in bilateral cochlear implant users | |
| BulkRNABert：基于批量RNA测序语言模型的癌症预后预测 | Gelard, M. | N/A | BulkRNABert: Cancer prognosis from bulk RNA-seq based language models | |
| 循环中的肌肉因子鸢尾素（irisin）水平是否与2型糖尿病相关？一项系统综述与荟萃分析 | Aminov, E. | N/A | Are circulating levels of the myokine irisin linked to type 2 diabetes? A systematic review and meta-analysis | |
| 通过从批量转录组到单细胞转录组的半监督迁移学习，识别肿瘤中的耐药性单个细胞。 | Huang, K. | N/A | Identifying drug-resistant individual cells within tumors by semi-supervised transfer learning from bulk to single-cell transcriptome | |
| 基因组变化在同属物种对之间存在显著差异。 | Francis, W. R. | N/A | Genomic changes are varied across congeneric species pairs | |
| 撤回：ATP依赖性转位酶SMARCAL1、ZRANB3和HLTF在叉逆转过程中对DNA损伤的链依赖性绕过 | Adolph, M. B. | N/A | WITHDRAWN: Strand dependent bypass of DNA lesions during fork reversal by ATP-dependent translocases SMARCAL1, ZRANB3, and HLTF | |
| 记录出生后第一个月内小肠转录组的变化 | Oliveria, L. F. S. | N/A | Cataloguing the postnatal small intestinal transcriptome during the first postnatal month | |
| 对老鼠而言，什么才是重要的？内部与外部环境对雄性老鼠对雌性吱吱声的声学反应的影响 | Brunner, L. R. | N/A | What matters to a mouse? Effects of internal and external context on male vocal response to female squeaks | |
| Boltz-1：生物分子相互作用建模的民主化 | Wohlwend, J. | N/A | Boltz-1: Democratizing Biomolecular Interaction Modeling | |
| rapgef1b在神经嵴特化和前体节中胚层模式化中的发育功能 | Prasad, T. | N/A | Developmental functions of rapgef1b in neural crest specification and presomitic mesoderm patterning | |
| 关键肠道微生物群分类群与环境敏感性和炎症相关生物标志物之间关系的研究 | Takasugi, S. | N/A | Key taxa of the gut microbiome associated with the relationship between environmental sensitivity and inflammation-related biomarkers | |
| 神经元功能中的高阶交互：从基因到生物物理模型中的离子电流 | Reva, M. | N/A | Higher-Order Interactions in Neuronal Function: From Genes to Ionic Currents in Biophysical Models | |
| 血管内皮生长因子-D在急性肺损伤期间改善肺血管完整性 | Yuan, Y. | N/A | Vascular endothelial growth factor-D improves lung vascular integrity during acute lung injury | |
| 在三家长期护理机构中，与养老院获得性肺炎相关的病原体的纵向流行率及共携带情况 | Whealy, R. N. | N/A | Longitudinal prevalence and co-carriage of pathogens associated with nursing home acquired pneumonia in three long-term care facilities | |
| SAR11类群中的生境特异性与少数处于高度选择压力下的基因有关。 | Tucker, S. J. | N/A | Habitat-specificity in SAR11 is associated with a handful of genes under high selection | |
| MethylQUEEN：一种基于甲基化编码的DNA基础模型 | Li, M. | N/A | MethylQUEEN: A Methylation Encoded DNA Foundation Model | |
| 基因组-热力学相位同步：麦克斯韦妖式的细胞命运转变调控 | Tsuchiya, M. | N/A | Genomic-Thermodynamic Phase Synchronization: Maxwell's Demon-Like Regulation of Cell Fate Transition | |
| 原发效应与传播效应：当与免疫检查点抑制结合时，α粒子与β粒子发射的放射性药物的不同免疫影响 | Kerr, C. P. | N/A | Priming versus propagating: distinct immune effects of an alpha- versus beta-particle emitting radiopharmaceutical when combined with immune checkpoint inhibition | |
| “宏基因组学日”：一个关于使用开放云生物信息学进行环境DNA（eDNA）和微生物组扩增子测序分析的简化研讨会。 | Belaouni, H. A. | N/A | "The Metagenomics Days": a simplified workshop on amplicon sequencing analysis with open cloud bioinformatics for eDNA and Microbiomes | |
| 线虫捕捉真菌少孢节丛孢（Arthrobotrys oligospora）渴求COQ7以缓解环境引发的铁过载 | Qunfu, W. | N/A | Nematode-Trapping Fungus Arthrobotrys oligospora is Hungry for COQ7 to Alleviate Environmentally Triggered Iron Overload | |
| 高风险儿童肿瘤中从肝母细胞瘤向癌的异步转变 | Chen, T.-W. | N/A | Asynchronous Transitions from Hepatoblastoma to Carcinoma in High-Risk Pediatric Tumors | |
| 一种通用策略赋予染料基因荧光，用于活细胞中蛋白质的无洗涤成像 | Zhou, X. | N/A | A General Strategy to Endow Dyes with Genic Fluorescence for Wash-Free Imaging of Proteins in Living Cells | |
| microGalaxy：一个用于微生物数据可重复性和FAIR（可查找、可访问、可互操作、可重用）分析的工具、工作流程和培训的入口平台。 | Nasr, E. | N/A | microGalaxy: A gateway to tools, workflows, and training for reproducible and FAIR analysis of microbial data | |
| 从现有遗传变异中进行的克隆扩张支撑了澳大利亚一种新兴植物病原体的进化。 | Sparks, A. L. | N/A | Clonal expansion from standing genetic variation underpins the evolution of an emerging plant pathogen in Australia | |
| 前额叶皮层活动预测高架十字迷宫中的焦虑样行为 | Smoak, M. A. | N/A | Prelimbic Cortex Activity Predicts Anxiety-Like Behavior in the Elevated Plus Maze | |
| 一种新颖的新生儿筛查方法：利用低成本铁粉进行非靶向蛋白质组分析 | Nakajima, D. | N/A | A novel newborn screening modality: Non-targeted proteome analysis using low-cost iron powders | |
| DIS3L2通过调节Akt信号通路对神经嵴细胞的存活至关重要。 | D'Silva, S. | N/A | DIS3L2 is essential for neural crest survival by modulating Akt signaling | |
| 从长春花（Vinca minor）中分离的内生真菌Cosmosporella sp. VM-42是一种生物活性化合物的来源，这些化合物对耐药细菌具有强效的活性。 | He, T. | N/A | The endophytic fungus Cosmosporella sp. VM-42 from Vinca minor is a source of bioactive compounds with potent activity against drug-resistant bacteria | |
| Withaferin A 通过下调 NDRG1 来克服缺氧介导的上皮间质转化（EMT）及肺腺癌和胶质瘤细胞的化疗耐药性。 | Mahajan, D. | N/A | Withaferin A downregulates NDRG1 to overcome hypoxia mediated EMT and chemoresistance in lung adenocarcinoma and glioma cells | |
| 玉米中的TIR-only蛋白ZmTIR1和ZmTIR2，而非ZmTIR3，可能通过形成凝聚体来赋予自激活的超敏反应。 | Kang, Z.-X. | N/A | Maize TIR-only Proteins ZmTIR1 and ZmTIR2, but not ZmTIR3 Confer Auto-active Hypersensitive Response Likely by Forming Condensation | |
| 《用于CRISPR应用的非冗余短聚合酶III启动子汇编》 | Deguchi, M. | N/A | A compendium of nonredundant short Polymerase III promoters for CRISPR applications | |
| 重塑表观基因组景观以促进面包小麦的物种形成 | Zhang, Z. | N/A | Reshaping epigenomic landscapes in facilitating the speciation of bread wheat | |
| 年龄与认知功能对噪声环境下语音神经追踪的影响 | An, H. | N/A | Effects of Age and Cognitive Functions on the Neural Tracking of Speech in Noise | |
| 感知基于变形的运动方向 | Kawabe, T. | N/A | Perceiving direction of deformation-based motion | |
| Enolase-1 在急性炎症期间对中性粒细胞的募集至关重要。 | Lu, H.-Y. | N/A | Enolase-1 is essential for neutrophil recruitment during acute inflammation | |
| CRISPR-Cas系统监管多种抗噬菌体防御机制。 | Li, M. | N/A | CRISPR-Cas supervises diverse anti-phage defense systems | |
| 用于微槽基底上细胞核聚类的变分自编码器模型：疾病诊断的潜力 | Roellinger, B. | N/A | A Variational Autoencoder Model for Clustering of Cell Nuclei on Microgroove Substrates: Potential for Disease Diagnosis | |
| 《番荔枝高质量基因组组装为这一新兴水果作物提供了功能性见解》 |
该研究通过对番荔枝（Annona squamosa，又称释迦果）进行高质量基因组测序和组装，深入解析了这一新兴热带水果作物的基因组特征和功能基因。研究不仅揭示了番荔枝的基因组结构和进化历程，还鉴定出与果实品质、风味和抗病性相关的重要基因。这些发现为番荔枝的遗传改良和育种提供了宝贵的分子基础，有助于推动这一具有高经济价值作物的可持续发展。 | Bisht, M. S. | PDF | N/A | A High-quality Genome Assembly of Annona squamosa (Custard Apple) Provides Functional Insights into an Emerging Fruit Crop | | 开源细胞培养自动化系统，集成了细胞计数功能，用于微孔板培养的传代操作。 | Courville, G. | PDF | N/A | Open-source cell culture automation system with integrated cell counting for passaging microplate cultures | | 探索自然盟友：葡萄园中葡萄果蛾幼虫寄生蜂的调查与鉴定，以实现可持续管理 | Gomez-Llano, J. H. | PDF | N/A | Exploring natural allies: Survey and identification of larval parasitoids for sustainable grape berry moth management in vineyards | | 一种利用多聚腺苷酸聚合酶和寡聚脱氧胸苷酸依赖性的方法，用于纯化工程化环状RNA，以增强其在真核细胞中的蛋白质表达。 | Wei, L. | PDF | N/A | A poly(A) polymerase and oligo(dT)-dependent method for the purification of engineering circular RNAs that enhances protein expression in eukaryotic cells | | ThermoPlex：一种基于DNA热力学的靶向特异性多重PCR引物自动设计工具 | Agmata, A. | PDF | N/A | ThermoPlex: An Automated Design Tool for Target-specific Multiplex PCR Primers based on DNA Thermodynamics | | 2013年至2022年巴西米纳斯吉拉斯州牛只运输网络脆弱性分析 | Costa, A. C. T. R. B. | PDF | N/A | Network vulnerability of cattle movement in Minas Gerais, Brazil, from 2013 to 2022 | | 由钠动力驱动的平肠球菌V-ATP酶的ATP合成 | Otomo, A. | PDF | N/A | ATP synthesis of Enterococcus hirae V-ATPase driven by sodium motive force | | 成年小鼠视觉皮层中移植的中间神经元在新的眼优势可塑性时期的整合 | Rakela, B. | PDF | N/A | Integration of Transplanted Interneurons Over a New Period of Ocular Dominance Plasticity in Adult Mouse Visual Cortex | | 将酪氨酸羟化酶神经元中的Latrophilin-3条件性敲除（Lphn3-Th-Cre）与Lphn3全局敲除大鼠进行比较：Lphn3在酪氨酸羟化酶神经元中的作用对这一ADHD易感基因的认知和行为效应的影响。 | Regan, S. L. | PDF | N/A | Latrophilin-3 conditional knockout in tyrosine hydroxylase neurons (Lphn3-Th-Cre) compared with Lphn3 global KO rats: Role of Lphn3 in tyrosine hydroxylase neurons on cognitive and behavioral effects of this ADHD susceptibility gene | | 小白蛋白阳性中间神经元的形态计量学识别：一种数据驱动的方法 | Panday, M. | PDF | N/A | Morphometric Identification of Parvalbumin-Positive Interneurons: A Data-Driven Approach | | 哺乳动物杏仁核中未成熟神经元的系统发育变异：在灵长类扩展核中向新皮层投射的高发生率 | Ghibaudi, M. | PDF | N/A | Phylogenetic variation of immature neurons in mammalian amygdala: high prevalence in primate expanded nuclei projecting to neocortex | | 海马体中距离与位置的独立编码机制 | Nordlund, M. | PDF | N/A | An Independent Coding Scheme for Distance versus Position in the Hippocampus | | 用于阿尔茨海默病诊断和分期的FDG PET亚区域生物标志物：一个可解释且可理解的模型 | Rasi, R. | PDF | N/A | Subregional Biomarkers in FDG PET for Alzheimer's Diagnosis and Staging: An Interpretable and Explainable model | | 截短的TrkB：痛觉感受器中的主要TrkB亚型 | Ruparel, J. | PDF | N/A | Truncated TrkB: The predominant TrkB Isoform in Nociceptors | | 最佳耳蜗位置在电听觉中传递双耳时间线索 | Borjigin, A. | PDF | N/A | Best Cochlear Locations for Delivering Interaural Timing Cues in Electric Hearing | | 小学学生口腔微生物群与近距离接触之间的关联 | Dall'Amico, L. | PDF | N/A | Association Between Oral Microbiota and Close-Range Proximity in a Primary School | | 苜蓿根中的酚类化合物受到根瘤农杆菌（Agrobacterium fabrum）通过其物种特异性基因区域的影响。 | Padilla, R. | PDF | N/A | Phenolic compounds in Medicago truncatula roots are under the influence of Agrobacterium fabrum through its species specific-genes regions | | 营养诱导增强了植物对拮抗性昆虫食果动物的抵抗力。 | Jacobsen, D. J. | PDF | N/A | Vegetative induction increases plant resistance to antagonistic insect frugivores | | AtKC1通过其氨基端抑制结构域抑制AtAKT1的激活。 | Zheng, Z. | PDF | N/A | AtKC1 inhibits AtAKT1 activation via its amino-terminal inhibitory domain | | 用于大分子治疗剂胞质递送的条件性融合脂质纳米载体 | Zhong, Q. | PDF | N/A | Conditional fusogenic lipid nanocarriers for cytosolic delivery of macromolecular therapeutics | | 通过超声波信号可以检测组织中的生化状态。 | Ito, K. | PDF | N/A | Biochemical state in tissue can be detected through ultrasound signal | | 前脚掌着地与后脚掌着地对下肢损伤生物力学风险因素及急停跳跃任务表现的影响 | Huang, T. | PDF | N/A | Effects of Forefoot versus Rearfoot Landing on Biomechanical Risk Factors for Lower Limb Injuries and Performance During Stop-Jump Tasks | | 基于序列的协同进化预测物种特异性相互作用组 | Fernandez-Martin, M. | PDF | N/A | Sequence-based coevolutionary prediction of species-specific interactomes | | 在向新生态系统过渡的过程中，水平基因转移率会下降。 | Mishra, S. | PDF | N/A | Horizontal gene transfer rates decrease during transitions to new ecosystems | | 水平基因转移推断：基因存在-缺失优于基因树 | Mishra, S. | PDF | N/A | Horizontal Gene Transfer Inference: Gene presence-absence outperforms gene trees | | 基于3D结构的生成性小分子药物设计：我们实现了吗？ | Yang, B. | PDF | N/A | 3D Structure-based Generative Small Molecule Drug Design: Are We There Yet? | | 在膨压作用下，边界流动诱导的膜管化现象 | Xue, H. | PDF | N/A | Boundary flow induced membrane tubulation under turgor pressures | | 通过膜屈曲法测定高斯曲率模量和自发曲率 | Wang, M. | PDF | N/A | Determination of Gaussian curvature modulus and spontaneous curvature via membrane buckling | | 基因组改变与免疫微环境特征的组合与多种癌症类型患者的生存率相关。 | Bayati, M. | PDF | N/A | Combinations of genomic alterations and immune microenvironmental features associate with patient survival in multiple cancer types | | 向光蛋白的定位与相互作用调控莱茵衣藻的光生理过程 | Sharma, S. | PDF | N/A | Phototropin localization and interactions regulate photophysiological processes in Chlamydomonas reinhardtii | | 栽培小麦和野生小麦种子携带微生物群的生态组装动态 | Ozkurt, E. | PDF | N/A | Ecological assembly dynamics of the seed-borne microbiome in cultivated and wild wheat | | 利用全长16S rRNA测序技术评估饲料配方和年龄对实验室及大规模饲养的地中海果蝇目标肠道微生物群定殖的影响 | Mason, C. J. | PDF | N/A | Utilizing full-length 16S rRNA sequencing to assess the impact of diet formulation and age on targeted gut microbiome colonization in laboratory and mass-reared Mediterranean fruit flies | | 在Citrin缺乏症中，甘油-3-磷酸激活ChREBP、FGF21转录以及脂肪生成。 | Tiwari, V. | PDF | N/A | Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency | | 物种丰富但数据匮乏：利用分布建模技术绘制南亚水域鲸类动物分布图 | Samad, I. | PDF | N/A | Species rich but data poor: leveraging distribution modelling techniques to map cetacean occurrence in South Asian waters | | 病毒种群中的遗传变化：宿主物种组成的突然变化与逐渐变化如何影响病毒种群遗传变异性的稳定性和动态 | Silva, J. M. F. | PDF | N/A | Genetic shifts in viral populations: how sudden vs gradual changes in host species composition affect the stability and dynamics of genetic variability in viral populations | | 了解野生蜱种群中微生物群变异的机制 | Noguerales, V. | PDF | N/A | Understanding the mechanisms underlying microbiota variation in wild tick populations | | GPR4拮抗剂NE-52-QQ57在感染SARS-CoV-2的K18-hACE2转基因小鼠中提高了生存率，减轻了过度炎症反应，并降低了病毒载量。 | Wu, X.-J. | PDF | N/A | The GPR4 antagonist NE-52-QQ57 increases survival, mitigates the hyperinflammatory response and reduces viral load in SARS-CoV-2-infected K18-hACE2 transgenic mice | | 1型树突状细胞控制癌症中三级淋巴结构的形成、维持和功能。 | Mattiuz, R. | PDF | N/A | Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer | | SARS-CoV-2变种LF.7.2.1、NP.1和LP.8.1的病毒学与抗原特性 | Liu, J. | PDF | N/A | Virological and antigenic characteristics of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1 | | 小分子β-抑制蛋白调节剂 | Kahsai, A. W. | PDF | N/A | Small Molecule Modulators of Beta-arrestins | | 仿生多孔分级支架力学行为中实际应力与原位形态变化的关系 | Marchiori, G. | PDF | N/A | RELATIONSHIP BETWEEN ACTUAL STRESS AND IN SITU MORPHOLOGICAL CHANGES IN THE MECHANICAL BEHAVIOR OF BIOMIMETIC POROUS HIERARCHICAL SCAFFOLDS | | 靶向内皮细胞ERG以减轻视网膜病变中的血管退化和神经元缺血 | Ma, E. | PDF | N/A | Targeting endothelial ERG to mitigate vascular regression and neuronal ischemia in retinopathies | | MUTE驱动不对称分裂以在景天科多肉植物中形成气孔副卫细胞 | Cheng, X. | PDF | N/A | MUTE drives asymmetric divisions to form stomatal subsidiary cells in Crassulaceae succulents | | 基因标记的前髓鞘形成少突胶质细胞：连接少突胶质细胞生成与神经元活动的桥梁 | Bhambri, A. | PDF | N/A | Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity | | 《单细胞分辨率下的秀丽隐杆线虫神经系统性别特异性神经元调控蓝图》 | Haque, R. | PDF | N/A | A Blueprint of Sex-Specific Neuronal Regulation in the C. elegans Nervous System at Single-Cell Resolution | | 通过全视野视网膜电图揭示闪烁光诱导的小鼠视网膜刺激效应 | RAI, M. | PDF | N/A | Effect of flicker-induced retinal stimulation of mice revealed by full-field electroretinography | | 长期来看，产前压力对小鼠背侧纹状体及相关行为的细胞类型特异性影响 | Evans, M. M. | PDF | N/A | Long-term, cell type-specific effects of prenatal stress on dorsal striatum and relevant behaviors in mice | | SLC35A2功能丧失变异影响糖组学特征、神经元命运及网络动态。 | Dulcie, L. | PDF | N/A | SLC35A2 loss of function variants affect glycomic signatures, neuronal fate, and network dynamics | | TMEM63A，与低髓鞘化白质营养不良相关，是一种在进化上保守的髓鞘形成调节因子。 | Halford, J. | PDF | N/A | TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination | | 一类新型青霉素结合蛋白抑制剂用于应对耐药性淋病奈瑟菌 | Uehara, T. | PDF | N/A | A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeae | | 在果蝇（Drosophila melanogaster）中，脂肪组织中性别二态性的ATF4表达赋予了雌性应激耐受性。 | Grmai, L. | PDF | N/A | Sexually dimorphic ATF4 expression in the fat confers female stress tolerance in Drosophila melanogaster |