BioRxiv 2024-12-28 Papers

标题	作者	PDF链接	代码仓库	Title
如何利用转录组数据进行癌症治疗诱导耐药性的博弈论建模？以患者来源的胶质母细胞瘤类器官为例	Spekking, L.	PDF	N/A	How to use transcriptomic data for game-theoretic modeling of treatment-induced resistance in cancer cells? A case study in patient-derived glioblastoma organoids
自适应学习的物理感知光场显微镜技术实现了对三维亚细胞动态的长时间（全天）和毫秒级超分辨率成像。	Zhu, L.	PDF	N/A	Adaptive-learning physics-aware light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics
利用深度学习方法从单个神经元放电序列推断可塑性规则	Wang, X.	PDF	N/A	Inferring plasticity rules from single-neuron spiketrains using deep learning methods
视觉感知学习的不对称转移由几何不变性的稳定性决定。	Yang, Y.	PDF	N/A	The asymmetric transfers of visual perceptual learning determined by the stability of geometrical invariants
eIF2β与eIF5、eIF2B及5MP1相互作用的分子基础及其受CK2调控的机制	Wagner, P. A.	PDF	N/A	Molecular basis for the interactions of eIF2β with eIF5, eIF2B, and 5MP1 and their regulation by CK2
尽管存在竞争，但仍能共存：植被结构复杂性在演替过程中塑造了苔藓植物的多样性。	Hanusch, M.	PDF	N/A	Coexistence despite competition: Vegetation structural complexity shapes bryophyte diversity over succession.
在存在映射偏差的情况下，估计等位基因频率、祖先成分比例和基因型似然值	Günther, T.	PDF	N/A	Estimating allele frequencies, ancestry proportions and genotype likelihoods in the presence of mapping bias
细菌基因必要性的实验进化研究	Bao, L.	PDF	N/A	Experimental evolution of gene essentiality in bacteria
使用不同LED光照配方塑造羽衣甘蓝的形态和生理特性	Scandola, S.	PDF	N/A	Shaping Kale Morphology and Physiology Using Different LED Light Recipes
研究交配系统对秀丽隐杆线虫（C. elegans）耐药性进化的影响	Trubenova, B.	PDF	N/A	Investigating the consequences of the mating system for drug resistance evolution in C. elegans
具有不同轴突连接性的皮层投射神经元利用具有不同蛋白质组成的核糖体复合物。	Tran, T. P.	PDF	N/A	Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions
抑制PDE5通过特定激酶迅速诱导海马树突棘的非基因组增加。	Soma, M.	PDF	N/A	Inhibition of PDE5 induces rapid non-genomic increase in hippocampal dendritic spines via specific kinases
亨廷顿蛋白相互作用组揭示了亨廷顿蛋白在调控双链断裂DNA损伤应答（DSB/DDR）、染色质重塑和RNA加工通路中的作用。	Ratovitski, T.	PDF	N/A	Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathways
基于自动位置和形状优化的可变形大型TMS线圈的个性化电场模拟	Worbs, T.	PDF	N/A	Personalized electric field simulations of deformable large TMS coils based on automatic position and shape optimization
化学诱导型CRISPR/Cas9电路用于超高动态范围的基因扰动	Srinivasan, R.	PDF	N/A	Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation
生物分子凝聚体的细胞功能由其超微结构决定	Scholl, D.	PDF	N/A	Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
长期来看，芬诺斯坎迪亚（Fennoscandia）地区的石楠荒原和苔原上的维管植物和地衣群落的同质化，与一种具有化感作用的矮灌木的扩张有关。	Maliniemi, T.	PDF	N/A	Long-term homogenization of vascular plant and lichen communities across Fennoscandian heathlands and tundra is connected to the expansion of an allelopathic dwarf shrub
CAZyme3D：碳水化合物活性酶三维结构数据库	Shanmugam, N. R. S.	PDF	N/A	CAZyme3D: a database of 3D structures for carbohydrate-active enzymes
生物分子凝聚体能够诱导局部膜电位	Gurunian, A.	PDF	N/A	Biomolecular Condensates can Induce Local Membrane Potentials
细胞图谱技术揭示了小鼠前列腺的组织结构以及去势抵抗的决定因素	Cho, H.	PDF	N/A	Cellular cartography reveals mouse prostate organization and determinants of castration resistance
RNA结合蛋白HuR在胰腺癌恶病质中损害脂肪组织合成代谢。	Arneson-Wissink, P. C.	PDF	N/A	The RNA-binding protein HuR impairs adipose tissue anabolism in pancreatic cancer cachexia
物体类别训练对猕猴颞下皮层反应的影响与视觉层级内性能优化的更新是一致的。	Sörensen, L. K. A.	PDF	N/A	The effects of object category training on the responses of macaque inferior temporal cortex are consistent with performance-optimizing updates within a visual hierarchy
空间和特征依赖的皮层回路模型中扰动响应的精确线性理论	Chau, H. Y.	PDF	N/A	Exact linear theory of perturbation response in a space- and feature-dependent cortical circuitmodel
在人类唐氏综合症的兴奋性皮层神经元中，神经元网络活动和连接性发生了改变。	Peter, M.	PDF	N/A	Altered neuronal network activity and connectivity in human Down Syndrome excitatory cortical neurons
病理性α-突触核蛋白引发颗粒空泡变性，且不依赖于tau蛋白。	Dues, D.	PDF	N/A	Pathological α-synuclein elicits granulovacuolar degeneration independent of tau
在加利福尼亚旱地生物结皮中发现的新型球囊霉门-苔藓关联	Kelly, K. H.	PDF	N/A	Novel Glomeromycotina-Moss Associations Identified in California Dryland Biocrusts
绝对丰度揭示了蛙粪霉（Basidiobolus）作为跨域桥梁，间接增强了肠道微生物组的稳态。	Ghotbi, M.	PDF	N/A	Absolute abundance unveils Basidiobolus as a cross-domain bridge indirectly bolstering gut microbiome homeostasis
细菌中氨基酸合成与分解代谢电子传递的交叉调控	Mogi, H.	PDF	N/A	Cross-regulation of amino acid synthesis and catabolic electron transfer in bacteria
甲葡胺锑和别嘌呤醇治疗对利什曼病犬粪便微生物组谱的影响	Marti-Carreras, J.	PDF	N/A	Effects of meglumine antimoniate and allopurinol treatment on the fecal microbiome profile in dogs with leishmaniosis
剪接体破坏的直接和间接影响损害了无义介导的mRNA降解（Nonsense-Mediated mRNA Decay, NMD）对基因的调控。	Embree, C. M.	PDF	N/A	Direct and indirect effects of spliceosome disruption compromise gene regulation by Nonsense-Mediated mRNA Decay
miR-126调节神经祖细胞的发育	Bastiaans, J.	PDF	N/A	miR-126 modulates neural progenitor cell development
绿色合成的白兰银纳米颗粒具有杀灭病原体、抑制癌症、展示抗氧化和光催化特性的功能。	De Mel, S.	PDF	N/A	Green Synthesized Magnolia alba Silver Nanoparticles Kill Pathogens, Inhibit Cancer, and Display Antioxidant and Photocatalytic Properties
混合的DAMP/MAMP寡糖能够促进黄瓜的生长并增强其对真菌病原体的防御能力。	Pring, S.	PDF	N/A	Mixed DAMP/MAMP oligosaccharides promote both growth and defense against fungal pathogens of cucumber
角蛋白16在应激皮肤中空间上抑制I型干扰素反应	Cohen, E.	PDF	N/A	Keratin 16 spatially inhibits type I interferon responses in stressed skin
细胞形态学能够准确预测贴壁细胞的核形状。	Lawton, S.	PDF	N/A	Cell Morphology accurately predicts the nuclear shape of adherent cells
通过逆转外胚层区域化实现分化能力的表观遗传恢复	Sutcliffe, M. A.	PDF	N/A	Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation
使用小鼠ICM胚胎模型解码原始内胚层与外胚层之间的相互作用	Tan, B.	PDF	N/A	Decoding primitive endoderm - epiblast interactions using mouse ICM embryoids
在光遗传学视觉恢复中，原生视觉反应与假体视觉反应之间的相互作用	Carpentiero, E.	PDF	N/A	Interaction between native and prosthetic visual responses in optogenetic visual restoration
意志性停止之前会出现短暂的β波振荡。	Doutel Figueira, J. F.	PDF	N/A	Volitional stopping is preceded by a transient beta oscillation
在阿尔茨海默病（AD）中，受阻的AMPK-ULK1级联反应引发了线粒体功能障碍和与AD相关的病理改变，而二甲双胍能够缓解这些症状。	Mary, A.	PDF	N/A	Hampered AMPK-ULK1 cascade in Alzheimer disease (AD) instigates mitochondria dysfunctions and AD-related alterations that are alleviated by metformin
T型Cav3.2钙通道在人类背根神经节神经元中的功能表达及性别二态性	chemin, j.	PDF	N/A	Functional expression and sex dimorphism of the T-type Cav3.2 Calcium Channel in human DRG Neurons
大脑与深度神经网络中语音和语言的收敛表征及其时空动态	Chen, P.	PDF	N/A	Convergent representations and spatiotemporal dynamics of speech and language in brain and deep neural networks
人类中央前回神经元将听与说的语音序列连接起来	Xu, D.	PDF	N/A	Human precentral gyrus neurons link speech sequences from listening to speaking
钙离子动态调节发育节奏，从而在进化过程中产生不同的轴突束长度	Lindhout, F. W.	PDF	N/A	Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths
流体智力与认知地图形成的神经测量相关	Tenderra, R. M.	PDF	N/A	Fluid intelligence relates to neural measures of cognitive map formation
糖化胶原蛋白上生物膜的形成调节变形链球菌细菌外泌体的产生及其内容物。	Leiva-Sabadini, C.	PDF	N/A	Biofilm formation on glycated collagen modulates Streptococcus mutans bacterial extracellular vesicle production and cargo
染色体末端通过RAP1介导的DNA-PK抑制实现保护	Eickhoff, P.	PDF	N/A	Chromosome end protection by RAP1-mediated inhibition of DNA-PK
可扩展的功能性肝细胞源自原代细胞，助力肝脏治疗	Mallanna, S. K.	PDF	N/A	Expandable, Functional Hepatocytes Derived from Primary Cells Enable Liver Therapeutics
解析内吞适配蛋白CALM与含有磷脂酰肌醇4,5-二磷酸酯的模型膜结合时的结构分子细节	Santamaria, A.	PDF	N/A	Untangling structural molecular details of the endocytic adaptor protein CALM upon binding with phosphatidylinositol 4,5-bisphosphate-containing model membranes
来自下波波阿吉组（卡尼阶，三叠纪）的一种新变头螈科（离片椎目）骨床及对离片椎目骨骼分选的评估	Kufner, A.	PDF	N/A	A new metoposaurid (Temnospondyli) bonebed from the lower Popo Agie Formation (Carnian, Triassic) and an assessment of skeletal sorting in temnospondyls
负责玉米（Zea mays）氮吸收的导水根	Jiang, Y.	PDF	N/A	Water-conducting roots responsible for nitrogen uptake in maize (Zea mays)
精英控制者对短暂HIV病毒血症的多维度B细胞反应	Muir, L.	PDF	N/A	Multifaceted B-cell response to transient HIV viraemia in elite controllers
通过循环原位杂交进行空间信息表型分析，识别出系统性硬化症中新型成纤维细胞群体及其致病微环境。	Li, Y.-N.	PDF	N/A	Spatially informed phenotyping by cyclic-in-situ-hybridization identifies novel fibroblast populations and their pathogenic niches in systemic sclerosis
通过对化疗后重新增殖的髓系细胞进行单细胞转录组分析，鉴定出一种具有促肿瘤活性的中性粒细胞样单核细胞亚群。	Ding, Z.-c.	PDF	N/A	Single-cell transcriptome profiling of the myeloid cells repopulating after chemotherapy identifies a neutrophil-like monocyte subset with pro-tumor activities
针对急性髓性白血病的基因编辑“通用”供体CAR T细胞策略	Kadirkamanathan, R.	PDF	N/A	Base edited "universal" donor CAR T cell strategies for acute myeloid leukaemia
1型淋巴细胞和干扰素-γ在丘脑中积聚，并在创伤性脑损伤后限制癫痫易感性。	Mroz, N. M.	PDF	N/A	Type 1 lymphocytes and interferon-γ accumulate in the thalamus and restrict seizure susceptibility after traumatic brain injury
团结一致：从退化的永久冻土中分离并鉴定产胞外多糖的细菌	Waqas, M.	PDF	N/A	Stick together: Isolation and characterization of exopolysaccharide producing bacteria from degraded permafrost soils
PSGL-1通过空间阻碍机制将HIV Env排除在病毒颗粒表面之外，这一过程涉及十聚体重复序列（DR）的结构折叠。	Tiwari, S.	PDF	N/A	PSGL-1 excludes HIV Env from virion surface through spatial hindrance involving structural folding of the decameric repeats (DR)
构建药物敏感型耳念珠菌菌株	Hassan, M.	PDF	N/A	Construction of a drug sensitised Candida auris strain
空间异质性影响弧菌（Vibrio anguillarum）中噬菌体与宿主的共存动态以及噬菌体抗性的发展。	Chen, L.	PDF	N/A	Spatial heterogeneity influences phage-host co-existence dynamics and phage resistance development in Vibrio anguillarum
Tapetum特异性TA29启动子受顺式元件调控，这些顺式元件能够结合正调控因子和负调控因子。	Sharma, P. A.	PDF	N/A	Tapetum specific TA29 promoter is regulated by cis- elements binding to positive and negative regulators
对太平洋牡蛎（Magallana gigas）中染色质免疫共沉淀（ChIP-Seq）方法的基准测试	Dellong, A.	PDF	N/A	Benchmarking of Chromatin Immunoprecipitation (ChIP-Seq) methods in the Pacific oyster Magallana gigas
载脂蛋白-L1 G1变异在载脂蛋白-E敲除小鼠中导致脑积水，但不导致动脉粥样硬化。	Yoshida, T.	PDF	N/A	Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice
在苔藓叶片细胞重编程中的生长素波动与PIN蛋白极化	Tang, H.	PDF	N/A	Auxin fluctuation and PIN polarization in moss leaf cell reprogramming
朝着社区驱动的视觉蛋白质组学迈进：利用大规模冷冻电子断层扫描技术研究莱茵衣藻	Kelley, R.	PDF	N/A	Towards community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii
KDM6组蛋白去甲基化酶抑制剂GSK-J4在多发性骨髓瘤细胞中诱导金属和应激反应	Cribbs, A. P.	PDF	N/A	The KDM6 histone demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells
推断马达加斯加指猴（Daubentonia madagascariensis）的精细尺度突变和重组率图谱	Soni, V.	PDF	N/A	Inferring fine-scale mutation and recombination rate maps in aye-ayes (Daubentonia madagascariensis)
在活体人类和小鼠细胞的基因组中，DNA:RNA杂交G-四链体的主要形成	Tan, Z.	PDF	N/A	Dominant Formation of DNA:RNA Hybrid G-Quadruplexes in the Genomes of Living Human and Mouse Cells
以下是这段英文的中文翻译：

分子决定因素导致p115RhoGEF和PDZRhoGEF被激活的Gα13差异性招募的机制

翻译说明： - "Molecular determinants" 翻译为“分子决定因素”，指的是在分子层面上起决定作用的因素。 - "underlying" 翻译为“导致”或“基于”，表示这些因素是某种现象或机制的基础。 - "differential recruitment" 翻译为“差异性招募”，指的是两种蛋白质（p115RhoGEF和PDZRhoGEF）被激活的Gα13以不同方式或程度招募的过程。 - "activated Gα13" 翻译为“激活的Gα13”，指的是处于激活状态的Gα13蛋白。